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Lunch 16 0 ASSIST Industry Meeting Thursday January 26, 2017 – Raleigh, NC 1

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  • Lunch

    160

    ASSIST Industry Meeting

    Thursday January 26, 2017 – Raleigh, NC

    1

  • Keynote Address

    Dr. Gül Ege, R&D Senior Director, SAS Institute

    2

    Co pyr ight © SAS Inst i tute Inc . A l l r ights reser ved.

    How Do We Analyze Healthcare Wearable Data?

    Dr. Gul EgeSenior Director R&D, Advanced Analytics

  • #analyticsx

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Agenda• NCSU-ASSIST & SAS Collaboration• Health IoT business impact• Analytical methods for health and wellness data:

    Electrocardiogram Anomalies: Motif discovery Activity and fall detection: Enterprise Miner modelsAsthma detection: Time Frequency Analysis functions

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

  • #analyticsx

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Healthcare Industry Trends• Population growth especially elderly segment• Top medical spend:

    Avoidable and repeat hospitalizationTreating chronic conditions

    • Challenges in medication compliance • Increased acceptance of technology

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    $170 billion to $1.6 trillion / year by 2025

    Total across industry verticals: $3.9-11.1 trillion

    Continuously monitoring chronic conditionsDiabetes, Asthma, Cardiac problems

    $700 billion/year: public health improvement by monitoring air and water quality improvements

    Impact of IoT in Health and Wellness

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    ECG – detecting cardiac malfunctions

    Activity detection:Interpreting health dataElderly, remote care

    Detection of wheezing on streaming data : asthma attack prevention

    Analytical methods applied to health data

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Heart disease causes 1 in every 4 deaths- Centers for Disease Control & Prevention

    2008-2010

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    RabbitMQ

    SAS ESP

    ECG pads in shirt

    Sensor board

    Bluetooth Low Energy(BLE)

    NCSU Android app w/SAS mods

    WiFi

    Current Architecture NCSU-ASSIST ECG Shirt

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    SStreaming Analytics – Multi-phase Analytics

    SAS-generated Insights

    Investigative Discovery Streaming Events

    Enrichment Analytic BusinessData Models Rules

    Streaming Events

    SAS In-Memory

    Publ

    ish

    Subs

    crib

    e

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    SAS® Event Stream ProcessingKey Characteristics

    Technology Is the architecture to process steams of data events, on the move, prior to storage, when events happen

    SpeedProcesses huge volumes of streaming data flowing at very high rates (Millions of events/sec) with very short latency (

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Streaming ECG data

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Motif DiscoveryA motif is a repeated pattern in a data sequence

    Measure similarity between a target sub-sequence and the input stream

    Computationally intensive

    Enables early failure warning

    Provides anomaly detection based on motif density

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Motif Discovery: sliding window

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    MMotif Discovery on ECG

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Interpreting health vitals in light of the activity

    Routine elderly care: activity and falls

    Classify activity signals

    Contextualize ECG signals

    Prevent emergencies

    Health Wearables: Activity Detection

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Methods for Activity Detection X | Y | Z

    Max/mean/rangestandard deviation

    median absolute deviationdistance between peaks

    Energy/entropy

    TIME DOMAIN

    Feature extraction completed in SAS IML.

    max frequency,

    ,FREQUENCY

    DOMAIN

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Methods for Activity DetectionSAS Enterprise Miner Modeling

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Methods for Activity DetectionEnterprise Miner Modeling

    ModelMisclassification Rate

    4 activities 12 activities

    Neural Network 4.30% 7.69%

    Gradient Boosting, PCA 6.58% 12.65%

    Decision Tree, Variable Selection 11.35% 30.20%4 activities: sitting, standing, laying, & moving (walking, sit-to-stand, etc.)

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Chronic disease with no cure

    Inflamed airways: difficulty moving air in and out of the lungs

    242million people affected /489K deaths in 2013

    Symptoms: coughing, wheezing, shortness of breath

    Death and emergency room visits can be minimized by early detection and treatment (inhalers)

    Asthma detection on streaming data

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Short Time Fourier Transforms

    Fourier Transformation with very small moving windows

    Used for detection and classification

    Capture how the frequency of a signal is changing over time

    Vibration & sound data

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    NNormal Breathing

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    WWheezing

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Detecting onset of wheezing

    C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Running on Streaming Data

  • C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .C op yr i g h t © 2016 , SAS Ins t i t u te Inc . A l l r i g h ts r eser v ed .

    Sources of breathing and Wheezing Data Coviello, Jessica S. Auscultation Skills: Breath & Heart Sounds. Lippincott Williams & Wilkins, 2013.

    Wrigley, Diane. Heart & Lung Sounds Reference Library. PESI HealthCare, 2011.

    Sources of activity data: Davide Anguita, Alessandro Ghio, Luca Oneto, Xavier Parra and Jorge L. Reyes-Ortiz. A Public Domain Dataset for Human Activity Recognition Using Smartphones. 21th European Symposium on Artificial Neural Networks, Computational Intelligence and Machine Learning, ESANN 2013. Bruges, Belgium 24-26 April 2013.Bogdan Kwolek, Michal Kepski, Human fall detection on embedded platform using depth maps and wireless accelerometer, Computer Methods and Programs in Biomedicine, Volume 117, Issue 3, December 2014, Pages 489-501, ISSN 0169-2607

    Fiber Assemblies for Flexible and Breathable Thermal Conductors Philip Bradford, Associate Professor

    Department of Textile Engineering, Chemistry and Science

    NC State University

    29

  • Thermoelectric devices require maximum heat differential across the device

    Transfer of body heat to device is importantCan be accomplished through heat spreader

    Transfer of heat away from the device on the environmental side is important

    Can be accomplished through heat sink

    Major issues for wearable devices For maximum comfort heat spreader should be very flexible and porous to water vapor

    For completely flexible TEGs there are no options for flexible heat sinks

    30

    Motivations

    CNT Production in My Lab

    31

    C2H2 2C + H2750oC

    FeCl2 Catalyst

    Growth process based on publication by Inoue et al, Appl. Phys. Lett. (92) 2008

    Length-to-diameter ratio of ~ 100,000

    This is same as…

    …a human hair that is 30 feet long!

    … a pencil that is half a mile long!

  • 32

    Drawable CNT Sheets

    33

    Carbon Nanotube Sheet Take-up

  • If the mandrel is traversed during takeup, large pieces of fabric are produced

    Basis weight is determined by number of layers.

    34

    Carbon Nanotube Fabrics

    Based on CNT arrays

    Hierarchical porosity

    Focus on structural stability, adjusting fiber volume fraction

    35

    Flexible Heat Sinks

    5 cm

  • Carbon post treatment for structural stability

    36

    Flexible Heat Sinks

    Bradford et al., Carbon, 2011

    Flexbile TEGs often embedded in PDMS

    Will explore this material as our structural binder

    37

    Flexible Heat Sinks

  • CNT sheet – polymer nanofiber hybrid fabrics

    Two processes combined to create high strength, conductive nanofiber structures

    38

    Breathable Heat Spreaders

    Yildiz et al., Nanoscale, 2015

    39

    Breathable Heat Spreaders

  • 40

    Breathable Heat Spreaders

    0

    0.5

    1

    1.5

    2

    2.5

    0 5 10 15

    Stre

    ss (M

    Pa)

    Strain (%)

    a 0% CNT15% CNT30% CNT60% CNT100% CNT

    0

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    0 5 10

    Stre

    ss (M

    Pa)

    Strain (%)

    b 0% CNT15% CNT30% CNT60% CNT100% CNT

    0

    50

    100

    150

    200

    0 10

    Stre

    ss (M

    Pa)

    Strain (%)

    c 0% CNT15% CNT30% CNT60% CNT100% CNT

    0

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    As-produced Consolidated Calendered

    Spec

    ific

    Stre

    ngth

    (M

    Pa/g

    cm-3

    )

    d 0% CNT15% CNT30% CNT60% CNT100% CNT

    0

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    10

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    35

    0 20 40 60

    Spec

    ific

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    ngth

    (g

    /tex)

    Basis Weight (g/m2)

    e Carded and bondedSpunbond

    Hybrid Calendered Fabrics

    10

    100

    1000

    10000

    100000

    0.1 1 10 100

    Tens

    ile S

    tren

    gth

    Incr

    ease

    with

    CN

    Ts (%

    )

    CNT ratio (%)

    f Other Electrospun CompositesThis Study, As-produced (30%CNT)This Study, Calendered (30% CNT)

    Understand structure – thermal property relationships of our materials

    Through collaborations with ASSIST members

    Integrate these platforms into ASSIST testbeds

    41

    Path Forward

  • Thank you for your attention!

    Contact information

    [email protected]

    919-515-1866

    www.go.ncsu.edu/Bradford

    42

    Q&A

    Emerging Research Highlight: Strain Energy and Piezoelectric Harvesting Circuit DesignDr. Mehdi Kiani (Pennsylvania Sate Unviersity

    43

  • 44ICSL Lab

    Integrated Circuits and Systems Lab (ICSL)Electrical Engineering Department, Pennsylvania State University

    Efficient Circuit Techniques for Mechanical Energy

    Harvesting

    January 2017

    Miao Meng and Mehdi Kiani

    Collaborators: Susan Trolier-McKinstry, Shad Roundy, and Chris Rahn

    45ICSL Lab

    Multi-Beam Mechanical Wrist/Elbow Harvester

    Prof. Susan Trolier-McKinstry

    Prof. Shad Roundy

    Wrist-worn Harvester

    Elbow Joint Harvester

    Initial Target: 50 μW from wrist under walking conditions

    Target: 2 mW under walking conditions

  • 46ICSL Lab

    Creating a prototype of the chest belt harvester using PVDF with parallel electrodes

    PVDF

    Webbing (also acts as strain limiter)

    Soft fabric belt with Teflon OD for low friction

    Adjustable buckle for webbing

    Aluminum link

    Mechanical Chest Harvester

    Prof. Chris Rahn

    47ICSL Lab

    • Design Challenges• Piezoelectric Harvester Equivalent Circuit• Interface Circuit Structures

    Standard Interface Circuit

    Synchronized Switching Harvesting with Inductor (SSHI)

    Intermediate Inductor with Automatic Peak Detection

    • Simulations and Measurement Results with Discrete Implementation

    Outline

  • 48ICSL Lab

    • Decaying sinusoidal with varying envelope mostly below the required voltage across the supercapacitor

    • Changing input frequency makes switching techniques hard to implement

    Design Challenges

    • Ability to harvest energy from multiple (for e.g. 6) beams with unknown phase shifts

    • Modularity: Ability to combine different boards, each supporting multiple beams

    49ICSL Lab

    Piezoelectric-Based Mechanical Harvester Equivalent Circuit Model

    The current source provides current proportional to the input vibration amplitude, the current is represented as ip=IPsin pt

    Cp represents the plate capacitance of the piezoelectric material

    Rp represents the damping loss

    Y. Ramadass and A. Chandrakasan, “An efficient piezoelectric energy harvesting interface circuit using a bias-flip rectifier and shared inductor,”IEEE J. Solid-State Circuits, vol. 45, no. 1, pp. 189–204, 2012.

    RpCp 45 nF

  • 50ICSL Lab

    Standard Energy Harvesting Interface

    Full-bridge rectifier and smoothing capacitor, CRECT

    When VBR is larger than VRECT + 2VD, the rectifier is conducting (VD: diode turn-on voltage)

    Not suitable when the signal has a decaying envelopeY. Ramadass and A. Chandrakasan, “An efficient piezoelectric energy harvesting interface circuit using a bias-flip rectifier and sharedinductor,” IEEE J. Solid-State Circuits, vol. 45, no. 1, pp. 189–204, 2012.

    51ICSL Lab

    Synchronized Switching Harvesting with Inductor (SSHI)

    Y. Ramadass and A. Chandrakasan, “An efficient piezoelectric energy harvesting interface circuit using a bias-flip rectifier and sharedinductor,” IEEE J. Solid-State Circuits, vol. 45, no. 1, pp. 189–204, 2012.

    Parallel switch (M1) and inductor (LBF) and a bridge rectifierM1 is briefly turned on when ip changes direction, L flips the voltage of the piezo element (VBF)

  • 52ICSL Lab

    Intermediate Inductor Circuit

    Two Advantages:

    Instead of charging Cp from V+PZT(Pk) to V-PZT(Pk), it charges Cp from 0 to VPZT(PK), saving current from charging Cp

    Using L as a current source, the effect of forward voltage across the rectifier can be reduced

    53ICSL Lab

    Simulation Results with Ideal Components

    Vp_unloaded = 3V

    Vp_unloaded = 0.4V Vp_unloaded = 0.25V

  • 54ICSL Lab

    Intermediate Inductor Discrete Implementation with Shared Inductor

    55ICSL Lab

    PCB Schematic

  • 56ICSL Lab

    PCB Layout and Proof-of-Concept Board

    Proof-of-concept board size: 65 mm x 65 mm, including footprints for battery and super-capacitor

    57ICSL Lab

    Modularity: Combining Two Separate Boards

  • 58ICSL Lab

    Simulation Results-Current

    During charging capacitor, each individual board generated 44 mAThe combined current of 88 mA was flowing into the storage capacitor

    59ICSL Lab

    Measurement Results - 1

    The peak voltage across the source increased from 350 mV to 700 mV thanks

    to switching inductor!

  • 60ICSL Lab

    Measurement Results-2

    The storage 10 μF capacitor is charged to 800 mV in 5 seconds from an unloaded 350 mV input

    61ICSL Lab

    Measurement Results-3

    Adding the second beam with in-phase signals increased storage-cap voltage from 800 mV to 1.2 V!

  • 62ICSL Lab

    • Conventional energy-harvesting interface circuit, SSHIand intermediate inductor were simulated andimplemented with discrete components on PCB

    • The intermediate-inductor technique demonstratedoptimal performance in our simulations

    • Discrete implementation of the intermediate-inductorcircuit showed promising results

    • Intermediate-inductor circuit successfully addressedlow input voltages and changing frequency

    • Simulation and measurement results demonstrated theability of combining several boards and charging thesame storage capacitor

    Conclusion

    63ICSL Lab

    Piezo Modeling with Real Device

    =_

    _ =+

    , =1

    = × 360 = tan

    Measurements were taken for different voltage amplitude and different frequenciesSolve the equations, we get

    Rp ~ 1 MCp ~ 45 nF

  • 64ICSL Lab

    Half-Wave Intermediate Inductor with Peak Detection Circuits in 0.35 um

    CMOS Technology

    Half-wave rectification with peak detectionM1 and M2 are on during inductor charging, M3 is on when M1 and M2 are off to let piezo charge itself and inductor charge output at the same time

    65ICSL Lab

    Simulation Results

    Output is charging to 5 V in 500 msSwitching happens at the positive peak of Vp (voltage across piezo)The switching waveforms of M1, M2, and M3 show that the peak detection and switching generation circuits are working well

    Output Voltage

    Vp

    Switching of M1 and M2

    Switching of M3

  • 66ICSL Lab

    Power Consumption

    The power consumption summary of the proposed circuit with frequency of 100 Hz, supplied with 5V, ideal bias current and continuous non-damping signal with an open-circuit amplitude of ~3 V and ~0.35 V

    Dynamic PowerStatic Power

    Vp,open=3V Vp,open=0.35V

    Comparator 32 nW 43 nW 5.3 nWDelay Element 52 nW 53 nW 10 nWWhole Circuit 164 nW 200 nW 15.5 nW

    67ICSL Lab

    SSHI Discrete Implementation

    MCU to generate switch control signals.Zero-crossing detection to detect the first zero-crossing of input signal, then switching is synchronized for constant frequency.Active, passive, and full-bridge rectifier are connected in parallel, the best one from measurement will be used.

  • 68ICSL Lab

    SSHI PCB

    Board Size: 45 mm x 55 mm.

    Battery and super capacitor holders are added.

    Battery: coin battery (3V) with diameter of 20 mm.

    Super Capacitor: same size as battery.

    69ICSL Lab

    SSHI Measurement Results

    Measurements were made with the designed PCB for and results are compared for conventional full-bridge rectifier and SSHI. As shown in the picture below, for a unloaded Vp of 0.35V, conventional full-bridge could not harvest energy at all, on the other hand, SSHI can harvest energy to charge VSTORE to 0.45 V.