Lecture 12

• August 26, 2005

• Lehninger (4th Edition), Chapter 17

FATTY ACID DEGRADATION (OXIDATION)

LNC Chapter 17

LNC 10-1

LNC 10-6

LNC 10-8

LNC 10-15

LNC 10-16

UPTAKE and DISTRIBUTION in Mammals

LNC 17-1

LNC 21-40

ADIPOSE TISSUE

LNC 17-2

Chylomicron

LNC 21-39a

Structure of an LDL particle

LNC 21-39b

Breakdown/Oxidation of Fatty Acids

-Oxidation

Activation

LNC 17-5

LNC 17-6

C14 fatty acid 7 acetyl CoA

6 rounds of oxidation

LNC 17-7

LNC 19-8

LNC 17-9

How to deal with unsaturated fatty acids:

cis 3 - ordouble bond between

LNC 17-10

LNC 17-11

How to deal with a fatty acid

containing an

uneven number of carbons

C3

C4

LNC box 17-1

LNC box 17-2

catalase

Degradation ofvery long chainfatty acids in the

peroxisome

LNC 17-12

Glyoxalate Cycle inPlants

LNC 17-13

Ketone Bodies

LNC Fig 17-18

Conditions favoringketone body formation:

depletion of OAfor gluconeogenesis

acetyl-CoA becomesavailable forketone body synthesis

Metabolic Biochemistry

FATTY ACID SYNTHESIS

LNC Chapter 21

LNC Fig. 21-1

the enzyme has threefunctional regions:

- biotin carrier protein- biotin carboxylase- transcarboxylase

acetyl-CoA + CO2 ==> malonyl-CoA

LNC Fig. 21-4

acyl carrier protein

LNC Fig. 21-2

End of lecture 12

August 26, 2005