latin american section of the american nuclear society symposium 2005
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Latin American Section of the American Nuclear Society Symposium 2005 FDG Production at IEN/ CNEN - Rio de Janeiro, Brazil J.C.Suita. Instituto de Engenharia Nuclear. Foundation: 1962 280 employees today. /CNEN. - PowerPoint PPT PresentationTRANSCRIPT
Latin American Section of the American Nuclear Society
Symposium 2005
FDG Production at IEN/ CNEN - Rio de Janeiro, Brazil
J.C.Suita
Instituto de Engenharia Instituto de Engenharia NuclearNuclear
Foundation: 1962Foundation: 1962280 employees today280 employees today
/CNEN
It occupies an area of 146.000m2, in the Campus of the UFRJ, being 18.028m2 of constructed area.
Main Activities Areas: ReactorsCornerstone of the Institute, the research reactor Argonauta is nowadays one of IEN's installations designed for experimental activities in physics and reactor engineering. Together with the nuclear and thermohydraulic measurement laboratories, it is used for the development of new applications in nuclear techniques; in supporting technical studies for the project, license and operation of nuclear installations, in the irradiation and sample analysis, as well as in personnel training, with post-graduate and specialization courses.
Instrumentation and Human Reliability
IEN has developed more that 20 prototypes of spectrometry, radiation protection and nuclear medicine equipment during this period. The activities related to human reliability started with the Laboratório de Interfaces Homem/Sistema - LABIHS (Human/System Interface Laboratory), an installation that simulates the processes and the working environment in a nuclear plant control room.
Chemistry and Nuclear MaterialsThe research, development and services related to chemistry conducted by IEN include the following activities: chemical and metallurgical processes, environmental technology, chemical analysis and material tests. The development of methodologies that use ultrasound techniques to evaluate residual tension in structures/components of nuclear reactors and others, as well as the efficiency of the measures taken to decrease tension, is an example of how advanced IEN is in the material characterization field.
Radiopharmaceutical Radiopharmaceutical ProductionProduction
CV 28 Cyclotron - 1974 RDS-111 Cyclotron - 2002
Radiopharmaceutical Radiopharmaceutical Production at IENProduction at IEN
123123I-NaII-NaI
123123I-MIBGI-MIBG
1818 F-FDG F-FDG
DIRA/SERADDIRA/SERAD
Routine ProductionRoutine ProductionWeekly ScheduleWeekly Schedule
Irradiation:Irradiation:SundaySunday 04:00 - 07:00 pm Iodide 04:00 - 07:00 pm Iodide MondayMonday 08:00 am - 02:00 pm MIGB 08:00 am - 02:00 pm MIGBTuesday Tuesday 01:00 - 04:00 pm 01:00 - 04:00 pm IodideIodide
Chemical Process:Chemical Process:
MondayMonday 07:30 am - 10:00 am Iodide 07:30 am - 10:00 am Iodide Tuesday Tuesday 07:30 am - 11:30 am 07:30 am - 11:30 am MIGBMIGBWednesdayWednesday 07:30 am - 10:00 am 07:30 am - 10:00 amIodideIodide
FDG Production: DailyFDG Production: Daily
Quality ControlQuality Control
GCAcetonitrile
andEthanol
--Chemical Purity
7.07.07.5-8.0pH
Limulus Testand
Sterility
Limulus Testand Sterility
Limulus Test andSterility
Biological Purity
Half LifeGammaSpectrocopy:
> 99%
GammaSpectrocopy:
> 99%
Radionuclide Purity
HPLCF-/FDG> 96%
HPLCI-/MIBG
> 95%
HPLCI-/IO3
- > 97%Radiochemical Purity
18F-FDG123I-MIBGNa123I
GCAcetonitrile
andEthanol
--Chemical Purity
7.07.07.5-8.0pH
Limulus Testand
Sterility
Limulus Testand Sterility
Limulus Test andSterility
Biological Purity
Half LifeGammaSpectrocopy:
> 99%
GammaSpectrocopy:
> 99%
Radionuclide Purity
HPLCF-/FDG> 96%
HPLCI-/MIBG
> 95%
HPLCI-/IO3
- > 97%Radiochemical Purity
18F-FDG123I-MIBGNa123I
Positron Emission Tomography - PET
Number Installed in the world
0
200
400
600
800
1000
1200
1400
1600
81 86 87 88 89 90 91 92 93 94 95 96 97 98 99 2000 2001 2002
New Instalations for FDG ProductionNew Instalations for FDG Production 18O(p,n)18F
Ep = 11 MeV
T1/2 = 109 m
Current: 40 µA
FDG Production SystemFDG Production System
Establishing a PET Radiopharmaceuticals Establishing a PET Radiopharmaceuticals Production Facility in colaboration with IAEAProduction Facility in colaboration with IAEA
Double Hot Cells
Automated Vial Dispenser
Osmometer
HPLC
Gas Chromatography
Leak Detector
Dose Calibration
Spare Parts from CTI
Production of Production of 1818FF-- WITH WITH CV-28 CYCLOTRONCV-28 CYCLOTRON
M.C.M.R.
FDG Production in Brazil
S.Paulo - 2000 Rio - 2003
Recife - 2007
BH - 2007
Thank youThank you
I-123 UltrapureI-123 Ultrapure
1996 - IAEA-FZK-IEN : Instalation of KIPROS system
Xe(p,2n) Cs Xe I124 123123 123
Ep = 24 MeV
T1/2 = 13,6 h
Current: 20 µA
Yield: 3,5 mCi/µAh