l gabby navar symposium - medicine.tulane.edu report...for 2019, medical students annie bell and...

L GABBY NAVAR

SYMPOSIUM

30 Years of Excellence at Tulane!

ii

TABLE OF CONTENTS

Mission Statement .......................................... 3

1. Report From the Chair ............................. 4

2. Highlighted Events ................................... 6

3. Education ............................................... 12

Education Mission ................................... 12

Undergraduate Student Education ........ 12

Medical Student Education .................... 12

Graduate Student Education .................. 15

PhD Graduate Program ............................ 15

MS Graduate Program ............................. 16

4. Research ................................................ 22

Research Mission ................................... 22

Interdisciplinary Programs ...................... 23

Physiology Student Research Awards ..... 24

Summer Student Research ...................... 25

5. Visiting Scholars Program ...................... 28

6. Future Directions .................................... 36

7. Faculty and Staff .................................... 38

8. Department Publications ........................ 68

9. Abstract & Oral Presentations ................ 71

10. Financial Information .......................... 79

11. Outreach Program Participation .......... 86

12. Departmental & Other Events ............. 88

2018-2019 ANNUAL REPORT

Department of Physiology

July 1, 2018-June 30, 2019 3

MISSION STATEMENT

Physiology is the study of the mechanisms responsible for homeostasis in living organisms. As

such, the discipline of physiology focuses on normal functions of the body, and it provides the

foundation upon which we expand our knowledge and understanding of how life processes are

deranged by diseases, aging, and environmental stresses. Scientific investigations range in

scope from molecular and intracellular mechanisms to the functional integration of various organ

systems. As an essential component of medical education and biomedical research, physiology

contributes to our understanding of normal function that is a prerequisite to understanding

pathophysiologic processes, disease conditions and their treatment. Accordingly, the

department is fully committed to the principles of medical education and research, which are the

transmission of knowledge through teaching, the acquisition of knowledge through research,

and the dissemination and preservation of knowledge through publication.

The mission of the Department of Physiology is to:

provide a superior teaching resource in the Physiological Sciences to undergraduate,

medical and graduate students

achieve and maintain the highest measures of competitive research

provide service to the Medical School and University in an exemplary manner

Vision

“Integrating Life Sciences from Molecular and Cellular Mechanisms to the Organism”



July 1, 2018-June 30, 2019 4

1. REPORT FROM THE CHAIR

This annual report covers the activities and developments that occurred from July 1, 2018 to June 30, 2019. During this period, the Department of Physiology made progress in educational activities, research funding and further development of faculty in our department.

The major highlight for this period was the ‘L. Gabby Navar Symposium’, which commemorated my 30 years at Tulane as Professor and Chair of the Department of Physiology. I was impressed by the participation of many former trainees who traveled to New Orleans at their own expense. It was a truly enjoyable and rewarding experience. Clearly, this is one of the most memorable experiences of my professional career. I extend my sincere appreciation to Dr. Minolfa Prieto, Amelia and Debbie and others, who worked so hard to make this symposium a reality.

Our faculty continued to contribute to numerous activities and groups within Tulane. Notably, Dr. T. Cooper Woods served as vice chair of the General Medical Faculty during the year and Dr. Majid and Hering-Smith served on Tulane Senate representing the School of Medicine. Other faculty were also elected to several Tulane Committees as noted in other parts of this report.

The “Warren R. Bourgeois, III, MD, and Usha Ramadhyani, MD, Student Research Endowed Fund” entered its 6th year and has been particularly important since the AHA program for support of summer research fellowships for medical students was discontinued. Nevertheless, the Bourgeois award was able to support two students in 2018; Jennifer Hong, supervised by Dr. Minolfa Prieto and Stacy Yanofsky supervised by Dr. Ryosuke Sato. For 2019, medical students Annie Bell and Stephanie McNamara will receive the Bourgeois-Ramadhyani award. In addition, students had an opportunity to submit a research proposal for summer funding from the BMS ASPIRE grants. Three physiology student projects were selected including, Mardeen Karim, mentored by Dr. Jackson-Weaver; Annie Bell, mentored by Dr. Navar; and Stephanie McNamara, mentored by Dr. Zsombok. We have four DeBakey Scholars; Anna Hodges, mentored by Dr. Abdulnour-Nakhoul and Alexander Cao, mentored by Dr. Wu and Robert Drury and Jacob Packer both mentored by Dr. Jackson-Weaver. Mathew Hennrikus, a T2 medical student, is also a DeBakey Scholar recipient working under the supervision of Dr. Minolfa Prieto. Matthew will continue as a DeBakey Scholar until 2022. Three students will return to continue their projects from last summer and we have 7 volunteers. As part of their research experience, students who perform research during the summer will have an opportunity to submit their work for presentation at various scientific meetings including the Southern



July 1, 2018-June 30, 2019 5

Regional Meeting of the SSCI/AFMR that is held in New Orleans and the Annual Tulane Health Sciences Research Days.

With regard to our educational mission, the faculty continued to excel in their efforts to provide outstanding learning experiences to our medical students. These efforts were recognized by the Owl Club during their annual awards banquet. Our Human Physiology Course, under the directorship of Dr. Kenneth Mitchell, was nominated for the Best T1 Course, Dr. T. Cooper Woods was nominated for Best T1 Professor, and both Dr. Andrea Zsombok and Dr. Norman Kreisman were nominated for the Best T1 CBL Facilitator Award with Dr. Kreisman winning the award. Congratulations to all faculty who participated in teaching the medical students, graduate students and the undergraduate students in biomedical engineering.

We had a robust visiting scholars program intermingled with seminars from Tulane faculty. The highlight of our seminar program was our annual Mayerson-DiLuzio Memorial Lectureship. This year’s lecture was presented by Dr. R. Clinton Webb from the Department of Physiology at the Medical College of Georgia. More information about this lectureship along with a list of all our visiting speakers can be found under the Visiting Scholars Program section and in our website https://medicine.tulane.edu/departments/physiology/seminar-series.

Our master’s program has continued to grow with 19 students enrolled for the 2018-2019 academic year. The students did very well, with 18 graduating with an MS degree in May. We feel that our program has helped them become more competitive for medical school or other professional programs. Approximately 80% of our previous graduates have received acceptance letters to medical or other professional schools.

Competition for NIH funding continues to be fierce. The CoBRE that supported the HRCE for 15 years has been in its second no cost extension period and will be officially completed in July, 2019. I am very proud of the efforts of our faculty to obtain additional funding in order to make up for the loss of CoBRE support. Congratulations to Dr. Jean-Pyo Lee for receiving her first NIH RO1 in December 2018. However, it is vital that all of us recognize the urgency and make extra efforts to seek out all possible sources of extramural funding to be as competitive, creative and innovative as possible. Faculty who already have grant funding should strive to obtain additional grants from NIH and other sources. The success of the department depends on our ability to garner new research funding so we must increase our intensity and scout out societies, associations, foundations, VA, DoD and the pharmaceutical industry as well as the various funding programs from NIH. I encourage the faculty to band together to develop group projects and apply for program project grants and other multi-investigator projects. As I have previously stated, our extramural salary release funds provide us with the flexibility to carry out many discretionary activities including our educational programs and visiting scholars program.

I believe that our intense efforts will continue to reap benefits in the coming years. With everyone’s cooperation and strong effort, we will succeed and continue to grow in stature and gain further national recognition.

L. Gabriel Navar, Ph.D.

Chair, Department of Physiology Director, Center of Biomedical Research Excellence in Hypertension and Renal Biology Co-Director, Tulane Hypertension and Renal Center of Excellence



July 1, 2018-June 30, 2019 6

2. HIGHLIGHTED EVENTS

30 Years of Excellence at Tulane

L. Gabriel Navar, Professor and Chair of Physiology, celebrated 30 years

of excellence at Tulane with the ‘L. Gabby Navar Symposium’. Numerous

trainees noted below participated at their own expense to commemorate this

event, which took place on Friday, October 5, 2018.

Welcome Remarks/Introduction

Dr. Minolfa Prieto, Tulane University


Romancing the Macula Densa, From Humble Beginnings to Master

Regulator

Dr. P. Darwin Bell, University of Alabama

Department of Medicine

A Little Bedtime Reading: My first reading assignment from Dr. Navar

Dr. Matthew Walker, III, Vanderbilt University

Department of Biomedical Engineering

Navar & Mitchell: An Unexpected 30 Year Journey by a Texan and a Scot

Dr. Kenneth D. Mitchell, Tulane University


Renal autoregulation to NO regulation to NO-cytokine interaction: a

pleasant surfing for Majid-Navar through NO green wave

Dr. Dewan S.A. Majid, Tulane University


The Legend of Texican Navar

Dr. Rudy Ortiz, University of California at Merced

Department of Molecular and Cell Biology



July 1, 2018-June 30, 2019 7

Eicosanoid drugs for a complicated pathway developed by a crazy

scientist

Dr. John D. Imig, Medical College of Wisconsin

Department of Pharmacology and Toxicology

The Benefits of Being Mentored by the Energizer Bunny

Dr. Lisa Harrison-Bernard, LSUHSC


Intratubular Angiotensin II: A lifetime passion for an Aussie and a big

easy

Dr. Jia ‘Joe’ L. Zhuo, University of Mississippi

Department of Pharmacology and Toxicology

Molecular biological studies conducted with the greatest physiologist:

Elucidating the intracellular swamp!

Dr. Ryosuke Satou, Tulane University


The miracle of being the grandchild of a Thai movie: AT1R versus P2XR,

science or fiction?

Dr. Supaporn ‘Tom’ Kulthinee, Tulane University


Coming Full Circle: 'Fancy Equations' and Mathematical Modeling of

Renal Hemodynamics

Owen Richfield, Tulane University


Paying the Toll: TLR4 in vascular function

Dr. Edward W. Inscho, University of Alabama


Closing Remarks

Dr. L. Gabriel Navar, Tulane University




July 1, 2018-June 30, 2019 8

Physiology on Capitol Hill

Dr. Andrea Zsombok, as a member of the APS Science Policy

Committee, attended meetings on Capitol Hill along with US Senators

to advocate for biomedical research.

New Adjunct Appointment

Dr. Olan Jackson-Weaver, joined Tulane University in November 2018

as an Assistant Professor in the Department of Surgery with an Adjunct

appointment in the Department of Physiology.

New Adjunct Appointment

Dr. Gholam Ali is a Clinical Assistant Professor in the Heart and

Vascular Institute and joined the Physiology Department as an Adjunct

in November 2018.

NIH Grant for Alzheimer’s Research

Dr. Andrea Zsombok received a $334,000 supplement to her current

National Institute of Health grant that supports research into the brain's

role in diabetes. Diabetes is associated with an increased risk for all

dementias, including Alzheimer's disease.

NIH RO1 Grant Received

Dr. Jean-Pyo Lee received an NIH RO1 grant award from the National

Institutes of Neurological Disorders and Stroke. Her project was

entitled, “Combination treatment of ischemic stroke with perlecan DV

and neural stem cells.”



July 1, 2018-June 30, 2019 9

Best Student Poster Presentation Award

Owen Richfield, a graduate student, received the “Best Student Poster

Presentation Award” during the 2019 BMES/FDA Frontiers in Medical

Devices Conference that was held in Washington, DC from March 19-

21, 2019.

Annual Mayerson-Di Luzio Lectureship

Dr. R. Clinton Webb, Herbert Kupperman Chair in Cardiovascular

Disease, Medical College of Georgia, presented the 2019 Mayerson-Di

Luzio lecture entitled, “Mitochondria-derived DAMPs as a trigger of

innate immune responses and vascular inflammation in hypertension”.

30th Annual Health Sciences Research Days

Adrien Molinas, a postdoctoral fellow in Dr. Zsombok’s lab, received

the award for Research in Neuroscience for his poster entitled, “Insulin-

dependent decrease of excitatory neurotransmission in preautonomic

PVN neurons is reduced in diet-induced obese mice”.

2019 Experimental Biology Awards Received

Dr. Bruna Visniauskas, a postdoctoral fellow in Dr. Prieto’s laboratory,

received the Juan Carlos Romero and Postdoctoral Research

Recognition Award from the Water and Electrolyte Homeostasis

Section at the Experimental Biology meeting.

Dr. Adrien Molinas, a postdoctoral fellow in Dr. Zsombok’s laboratory,

received the Mead Johnson Award from APS Endocrinology and

Metabolism section at the Experimental Biology meeting.



July 1, 2018-June 30, 2019 10

NIH Grant Received

Owen Richfield, a graduate student, received a Research Fellowship

Award from NIH-NIDDK for 2 years for his project titled “Development

of a computational biomechanics model of the glomerulus to assess

risk of mechanical stress-induced glomerular injury in conditions of

reduced afferent arteriole vasoconstrictive response.”

2018 Outstanding Staff Award

Rose Grace, accountant, received the 2018 Outstanding Staff Award

for the Department of Physiology.

Owl Club Awards

Dr. Norman Kreisman received the T1 Best CBL Facilitator Award at

the Owl Club Awards Banquet that was held on May 10, 2019.

AHA Career Development Grant Received

Dr. Olan Jackson-Weaver, was awarded a 3-year American Heart

Association Career Development Grant. His research will focus on the

role of protein arginine methylation in the regulation of angiogenesis.



July 1, 2018-June 30, 2019 11

Milestone Service Awards

FACULTY

Dr. L. Gabriel Navar, Professor and Chair, celebrated 30 years of

service at Tulane.

Dr. Kenneth D. Mitchell, Professor, celebrated 30 years of service at

Tulane.

STAFF

Alex Castillo, Laboratory Research Technician, celebrated 15 years of

service at Tulane.

Weijian Shao, Medical Research Specialist, celebrated 20 years of

service at Tulane.

We thank them for their dedication to the Department and Tulane!



July 1, 2018-June 30, 2019 12

3. EDUCATION

Education Mission

Physiology contributes to our essential understanding of normal function that is a prerequisite to

understanding pathophysiologic processes, disease conditions and their treatment. The department is

fully committed to the principles of medical education, which are the transmission of knowledge through

teaching, the acquisition of knowledge through research, and the dissemination and preservation of

knowledge through publication. Accordingly, the Department is united in its commitment to the

performance of its teaching responsibilities and scholarly analysis which are incorporated into the Medical

and Graduate programs.

Undergraduate Student Education

The Physiology Department continued to have responsibility for the Quantitative Physiology course

taught to the undergraduate biomedical engineering students under the direction of Dr. Ming Li. This

well-received lecture-and-lab course covers aspects of Cellular Physiology, Neurophysiology, Muscle

Physiology, Cardiovascular, Respiratory, Renal, Gastrointestinal, Endocrine and Reproductive Physiology

with an emphasis on quantitative measurement and analysis by using the tools of Matlab programming

and calculus. The Quantitative Physiology also binds to an additional course, Experimental Physiology,

which offers a hands-on measurement of physiological activities using animal models or computer

simulating models in steps synchronized with the proceedings of Quantitative Physiology lectures. The

course also emphasizes medical application of physiology knowledge for diseases in the class lectures and

lectures using robot patients. It is anticipated that this course will serve as a conduit for the department

to have greater exposure to undergraduate students at Tulane and to recruit graduate students to the

department.

Medical Student Education

The Human Physiology course is a key component of the core integrated curriculum for first-year

medical students. Our course provides students with a clear exposition of the physiological principles,

concepts and mechanisms which form the basis of medical practice and the understanding of

pathophysiology. Dr. Kenneth D. Mitchell served as Course Director. In 2018-19, Human Physiology

was covered in 55 lectures organized within seven thematic modules:



July 1, 2018-June 30, 2019 13

1. Concepts in Cellular Structure and

Biomechanics

5. Renal and Body Fluids Physiology

2. Musclo-Skeletal Physiology 6. Gastrointestinal Physiology

3. Cardiovascular Physiology 7. Endocrine & Reproductive Physiology

4. Pulmonary Physiology

Each Module culminated in an examination which included questions from all four major courses

participating in the Integrative portion of the Phase 1 year (Biochemistry, Genetics, Histology, and

Physiology). Student performance was evaluated by the seven module exams followed by two NBME

board-style shelf exams utilizing questions from the physiology question bank at the NBME.

There was strong emphasis on clinical applications and integration of materials across courses throughout

our course. Each lecture was prefaced with a clinical vignette, which requires the students to utilize

basic principles to solve patient-centered problems. Additionally, the first page of each handout

contained specific learning objectives to guide students’ learning. We also offered four two-hour case-

based learning (CBL) sessions featuring clinical cases. Again this year, included three team based learning

(TBL) sessions in which students were provided reading material ahead of the TBL session. The students

then met in the DeBakey Classroom and answered questions based on the reading material, both

individually and as a group (of approximately 6 students). As with the previous academic year, we

incorporated into the course two T4 medical student-led CBL sessions in which small groups of students

(approximately 8-10 T1 students) discussed clinical cases related to either the gastrointestinal system or

the female endocrine/reproductive systems. Furthermore, we offered three self-directed learning (SDL)

experiences and time for independent study to allow medical students to develop the skills of lifelong

learning. Self-directed learning involves medical students’ self-assessment of learning needs; independent

identification, analysis, and synthesis of relevant information; and appraisal of the credibility of information

sources. The SDL involves an integrated, multidisciplinary module using the Tulane SDL standard fillable

form and follows the best practices for evidence based learning. Course directors, module directors and

faculty decide on a topic for SDL. Specifically, students are provided with a clinical case which is specific

and testable, requiring more than textbook knowledge, that students can learn on their own. Students

are expected to utilize source material with the aid of the library staff. Free time is provided in the

schedule for both individual self-study and group sessions, usually two to three hours for self-study

preparation and one to two hours for group discussion and feedback. Clear expectations with specific

objectives are provided for the SDL sessions. Objectives are specific enough that students know what is

expected of them. The learning objectives and the Tulane SDL form are posted on Canvas at least two

weeks ahead of scheduled group session. Students are to complete the first three steps before the group



July 1, 2018-June 30, 2019 14

session and upload as a pdf to Canvas prior to class. Completion of this form confirms that the student

has identified their own learning issues and attempted to identify their own resources, and gives an

opportunity for feedback on the adequacy of the process. SDL attendance is mandatory and participation

constitutes (3%) of students’ grades. Completion of the first three steps of the SDL form is required for

attendance in the group SDL sessions. SDL sessions are not recorded and can’t be completed at a later

date. Students are only allowed to miss SDL sessions for very serious reasons. At the group session,

faculty facilitators check to see that each student has brought to the session the completed SDL form

with reasonable evidence that the student has completed it independently. Group session is student-led

and facilitator guided. The time in the group sessions is carefully allotted. At the beginning of the session,

students review the overall objectives. The teams choose a captain for the SDL session. The captain

will open a new Tulane fillable SDL form and label it with the TBL/SDL team number, and include his/her

e-mail as contact for the group session. The captain for this SDL is responsible for sharing information

with their team mates and uploading the form to Canvas when it has been completed by the group. The

fillable SDL form is attached as a separate file in the course syllabus.

Two additional modules were offered in conjunction with the Foundations in Medicine and Clinical

Diagnosis Courses, one on heart sounds and the other on breath sounds. These sessions integrated

clinical medicine and physiological principles utilizing standardized patients, the Harvey simulator,

electrocardiography, and a hands-on approach to physical diagnosis. These sessions were aided by T4

students who served as preceptors for the T1 students. Dr. Jessica DeBord and Ross Klingsberg

presented clinical correlation lecture-demonstrations as preludes to each of the cardiology and

pulmonology sessions. Students rated these sessions very highly in their evaluations, particularly for

introducing realistic clinical scenarios and for aiding in the application of physiological principles and

concepts to clinical medicine.

The Office of Medical Education continued the process of inviting clinicians, several of whom have

experience writing questions for the NBME, to aid basic science course directors and faculty in evaluating

their questions. As a result, many questions were re-written to begin with a brief clinical vignette and

to otherwise place them into proper NBME format. Additionally, input from the clinicians was very

helpful in assessing the clinical relevance of the basic science questions. As a result, some questions were

eliminated because they were testing isolated facts or obscure clinical conditions that were not seen

even by specialists. However, we are continually developing a bank of new exam questions which are in

the NBME format.

Physiology faculty members and the Human Physiology course consistently have received accolades from

the students over the years and this year was no exception. Individual faculty members that were



July 1, 2018-June 30, 2019 15

nominated by the Owl Club for outstanding teaching were T. Cooper Woods, Norman R. Kreisman,

and Andrea Zsombok. Dr. T. Cooper Woods was nominated for Best Professor and Drs. Norman

Kreisman and Andrea Zsombok were nominated for best CBL Facilitator, and Physiology (Dr. Kenneth

D. Mitchell, Course Director) was nominated as Best First Year Course. Dr. Norman Kreisman won the

Best CBL Facilitator Award. The Cardiovascular Module (Dr. Craig Clarkson, Module Director) was

named as Best Module. In all, we are extremely proud of our faculty’s accomplishments and recognition

from the students. All of the physiology instructors are to be congratulated for their dedication to the

education mission of the Department and Institution, and their consistently outstanding teaching

performance.

Graduate Student Education

As a result of the MS graduate program, the Department has increased the number of graduate student

courses to include a complete course in medical physiology, cellular and molecular physiology and

advanced courses in renal, cardiovascular, signal transduction, membrane physiology and endocrine

physiology. Additional courses were added to cover topics in experimental physiology and translation

topics. These courses are well received by the students.

PhD Graduate Program

The Department of Physiology prepares graduate students for careers in many aspects of the biomedical

sciences. The educational goal is the development of the scientist-teacher who is prepared to conduct

independent, competitive research and to participate in the design and the delivery of current concepts

in Physiology. In addition to training students for the Ph.D. in Physiology, the faculty also serves as an

important resource for the interdisciplinary programs of Molecular and Cell Biology, Neuroscience as

well as the interdisciplinary programs in Bioinnovations and in Aging Studies.

The graduate program is supported by extramural funding, graduate school stipends, tuition waivers and

mentor’s research grants. Each student is expected to obtain extramural or mentor research support

for the dissertation portion of their training. The seminar course is a requirement each year. Registration



July 1, 2018-June 30, 2019 16

for dissertation research is allowed after the graduate student has presented their prospectus and had it

approved by their committee.

During the academic year 2018-2019, the graduate program had 5 graduate students enrolled in the PhD

program. 1. Sarah Abdullah, working with Dr. Olan Jackson-Weaver; 2. Sierra Butcher, a graduate

student in the Neuroscience Program, working on her thesis project with Dr. Andrea Zsombok; 3. You

Lu, a graduate student in Aging Studies, working on his thesis project with Dr. Ming Li and James Hyman;

4. Owen Richfield, a graduate student in the Departments of Mathematics and Physiology, working on

his thesis project with Drs. Ricardo Cortez and Dr. L. Gabriel Navar; and 5. Haoran Yang, working with

Dr. Hongju Wu.

Ph.D. Graduate

Students

Date of

Matriculation

Mentor(s)

Sarah Abdullah June 2019

BMS Program

Dr. Olan Jackson-Weaver

Sierra Butcher May 2015

Neuroscience Program

Dr. Andrea Zsombok

You Lu August 2016

Aging Studies Program

Dr. Ming Li

Dr. James Hyman

Owen Richfield August 2017

Bioinnovations Program

Dr. L. Gabriel Navar

Dr. Ricardo Cortez

Haoran Yang June 2019

BMS Program

Dr. Hongju Wu

MS Graduate Program

The Master of Science (MS) in Physiology Program is designed for students with a bachelor’s degree (BS

or BA) in a chemical/physical/biological discipline or pre-med program, seeking advanced training in the

physiological sciences, typically in preparation for admission to a professional medical program (e.g.



July 1, 2018-June 30, 2019 17

Medical School, Dental School, Physician Assistant program, Pharmacy School, Veterinary Medicine

School), or a Ph.D. program. This program is also helpful for preparation to work in academia, industry

or biotechnology. The MS students undertake a rigorous series of advanced courses in Physiology,

including Medical Terminology, Medical Physiology, Cardiovascular Physiology, Translational Physiology

(I & II), Renal Physiology, Membrane Physiology and Experimental Physiology. The students also take

courses in cell biology, biochemistry or neurosciences offered by other departments. The Medical

Physiology course is a six hour credit course that involves thirteen faculty members who present topics

in Homeostasis and Membrane Physiology, Neurophysiology, Cardiovascular Physiology, Pulmonary

Physiology, Renal Physiology, Gastrointestinal Physiology, Endocrinology and Reproductive Physiology.

Translational Physiology is a two-semester course that was created which aims to apply recent advances

in molecular and integrative physiology to clinical situations. It is specifically designed for graduate

students who are eager to translate the basic concepts they have learned in biomedical sciences into the

understanding of clinic diseases. The students analyze specific clinical cases and correlate their

knowledge in physiology with the diagnosis, treatment and complications of the diseases. Necessary

assistance in pharmacology and medicine is provided by the instructors to assure depth of analysis in the

clinical aspects. We also invite faculty from the department of Medicine and other clinical departments

to present case studies in the course. Our

program enrolled 20 students this academic

year. Last year we thought it was important to

recognize the students with the highest grades

in our program with an “Honors in Physiology”

award. This year this award was presented to

two students, Victoria Way and Giacomo

Adoncecchi. We feel that our program has

been instrumental in helping students become

more competitive for admission to medical

school or other professional programs. On

average, about 84% of our graduates from our

first three years (2015-2017) have received

acceptance letters to medical or equivalent

schools. Students that graduated in 2018 are

receiving responses to their applications now and we have been notified that at least 40% have already

been accepted. Congratulations to all our students and we wish them great success in their future

careers!

‘Honors in Physiology ’ awards were presented to two Physiology master students for the 2018-2019 academic year, Victoria Way and Giacomo Adoncecchi.



July 1, 2018-June 30, 2019 18

0

5

10

15

20

25

2014-15 2015-16 2016-17 2017-18 2018-19

Physiology MS Students Enrolled/Graduated

Enrolled Graduated

77.70%

75%

100.00%

Percent of Physiology MS Graduates Who Applied and were Admitted to Medical School

or Equivalent Programs

2014-15 2015-16 2016-17



July 1, 2018-June 30, 2019 19

Physiology Master Students Enrolled 2018-2019

Giacomo Adoncecchi

Norris Akpan

Mazin

Almashhadani*2

Reetom Bera

Dylan Dixon

Christine

Edomwande

Christopher

Gonzaba

John Hattier**

Romel Holmes, Jr

Haley Koenig

Nicholas Litsky

William Loupe

Joonwoo Nho†

Jared Rebman

Tina Reddy

Yu (Cindy) Sun

Sean Tran

Nicole Vasilakos

Jester Vasquez

Victoria Way

*2 2-year program in year 2 (Graduated in Dec. 2018); **Returned to complete Spring semester; †Medical leave



July 1, 2018-June 30, 2019 20

Physiology MS graduate courses offered during this fiscal year are listed in the table below.

2018 FALL COURSES

Course Code

Title CRN SCHEDULE Required/

Elective

Credit

GPSO-7175-01

Medical Terminology 80970 Online Required 3

GPSO-6010-01

Medical Physiology 81058 M/W/F 2:00-3:45 PM Required 6

GPSO-7910-01

Seminars in Physiology 39850 M 12:00-1:00 PM Required 1

GPSO-7350-01

Translational Physiology I 91597 F 10:00-11:45 AM Required 2

INTD-6010-01

Responsible Conduct of Research

83436 TH 3:00-4:00 PM Recommended 0

BMSP-6050-01

Advanced Cell Biology 91435 T/TH 9:30-11:00 AM Elective 3

NSCI-7110-01

Graduate Neuroscience 36928 T/TH 11:00-12:15 PM Elective 3

GBCH-

7500-01

Human Medical Cellular

Biochemistry

80516 T/TH 3:30-5:00 PM Elective 5

GPSO-7180-0

Selected Topics (Physiology

Basis of Disease) 93642 TH 1:00-3:00 PM Elective 2



July 1, 2018-June 30, 2019 21

2019 SPRING COURSES

Course

Code

Title CRN Required/

Elective

Schedule Credit

GPSO-6060-01

Experimental Physiology 29477 Required Thur 1:00-4:00 PM

2

GPSO-7910-01

Seminar Physiology 30546 Required Mon 12:00-1:00 PM

1

GPSO-7560 -01

Signal Transduction & Hormone Action

29478 Required Fri 2:00-4:00 PM

2

GPSO-7350-01

Translational Physiology II 35386 Required Tues 1:00-3:00 PM

2

GPSO-7600-01

Vascular Physiology 29475 Required Wed 10:00 – 11:30 AM Fri 8:30 – 9:55 AM

3

GPSO-6250-01

Membrane Physiology 29476 Elective Tues 3:30-430

2

GPSO-7180-0

Reg in Dept

Selected Topics

(Physiology Basis of Disease)

37659 Elective N/A 3

GPSO-7320-01

Renal Physiology 30294 Elective Tues/Thur 9:00-11:00 AM

3

GPSO-7980-0 Reg in Dept

Research Laboratory 37658 Elective 6 hours/week 3



July 1, 2018-June 30, 2019 22

4. RESEARCH

Research Mission A major challenge to the Department of Physiology is to attract and retain a nationally competitive

faculty. Through the years, the department has achieved success in recruiting highly talented new

investigators who have been able to obtain research support after they joined the Physiology faculty.

This recruitment has been aided by the salary initiatives undertaken by the Administration which

helped to make salaries in basic science departments more competitive. The reward and incentive

programs also help to encourage increased grant submissions by our faculty. Continued recruitment

and faculty retention are linked to the Administration’s increased commitment to these initiatives

and rectification of the well-recognized deficiencies in start-up packages, availability of modern

research space and salaries in comparison to institutions in the highest tier of research. Although

the department was markedly downsized after Katrina, recruitment efforts during the past few years

have partially restored our faculty numbers. We have a talented group of mid-career faculty

members who have been successful in obtaining extramural research support. Through their efforts

we reached a milestone with all of our post-Katrina faculty holding at least 1 NIH RO1 grant and

some holding more than one major research award. This external research support has helped to

make up for the major loss due to completion of the CoBRE grant. The great success by our faculty

has provided hope for a sustained funding environment even though the 15 years of CoBRE support

came to an end.

The CORE facilities of the Hypertension and Renal Center of Excellence are chaired by several

faculty and revenue is generated by the core facilities, especially the Molecular and Analytical Core

and the Phenotyping Core. A major objective for the coming year is to increase the revenue

generated by providing core services at competitive prices to both Tulane and non-Tulane research

groups and investigators.

During the period of this report, sources of extramural funding included grants from NHLBI,

NIDDK, NIGMS, LACaTs, American Heart Association, Novartis and Janssen Pharmaceuticals. The

faculty published 29 articles, book chapters, and reviews during 2018-2019, most of which

represented collaborative efforts among physiology department members or with collaborators

from other departments or institutions.



July 1, 2018-June 30, 2019 23

Interdisciplinary Programs Many of our faculty members are involved in the Interdisciplinary Graduate Programs in Molecular

and Cellular Biology and Neurosciences. The interdisciplinary graduate program in Bioinnovation

was established by the Biomedical Engineering and other Biomedical and Science Departments. This

training program is under the direction of the chair of BME Department, Don Gaver, and is funded

by the National Science Foundation (NSF) through the IGERT (Integrative Graduate Education and

Research Training) mechanism. The NSF training grant provides financial support and educational

resources to PhD students who conduct translational research in the Schools of Science &

Engineering and Medicine with the goal of developing innovative and cost-effective solutions to

complex biomedical problems. Additional programmatic links with the Schools of Business and Law

and the FDA further prepare trainees for careers as leaders at the interface of academia and

industry. We were very fortunate this year to have one student, Owen Richfield, from this very

competitive program join our department under the mentorship of Dr. Navar.

In addition, several of our faculty participate in the new undergraduate and 4+1 Master’s Degree

programs in Neuroscience. The Neuroscience group has been reorganized with the establishment

of the “Brain Institute” which will be of great benefit to neurophysiologists in our department. Dr.

Navar is the Co-Director of the Tulane Hypertension and Renal Center of Excellence (THRCE)

which brings together investigators from Departments of Medicine, Pediatrics, Pharmacology and

Physiology in the School of Medicine, from the Department of Epidemiology in the School of Public

Health and Tropical Medicine and from the Biomedical Engineering Department.

Another important program is the NIH-funded BIRCWH (Building Interdisciplinary Research

Careers in Women’s Health) program. The overall goal of this career development award is to

help ensure that a diverse pool of highly trained scientists is available in appropriate disciplines to

address the Nation’s biomedical, behavioral, and clinical research needs. BIRCWH supports

mentored research career development of junior FACULTY members who engage in

interdisciplinary basic, translational, behavioral, clinical, and or health services research relevant to

women’s health. Where appropriate, fellows use both sexes to better understand the influence of

sex as a variable in health and disease. Another program includes the NIH-NIGMS funded BUILD

(Building Infrastructure Leading to Diversity) Program at Xavier University, which was designed to

study and implement effective approaches to engaging and retaining students from diverse

backgrounds in biomedical research careers. These and other programs contribute to the overall

environment in our department and the School of Medicine.



July 1, 2018-June 30, 2019 24

Physiology Student Research Awards

The Department of Physiology has two research awards that are presented to eligible graduating medical students. These awards are named after two former Physiology Chairs, Dr. Hymen S. Mayerson and Dr. Nicholas R. DiLuzio, who had an impact on physiology research.

HYMEN S. MAYERSON AWARD

This award is in honor of Hymen S Mayerson, who joined the Department of Physiology

at Tulane University in 1926. He remained here with increasing responsibilities and

rank serving as Professor and Chair from 1945 until his retirement in 1965. This award

is presented to a graduating medical student who has demonstrated excellence in

scholastic achievement and who has made significant accomplishments in physiology

research.

NICHOLAS R. DI LUZIO AWARD

This award was established by Dr. Samuel L. Lassoff in memory of Dr. Nicholas Di Luzio,

who served as Professor and Chair of Physiology from 1968 until his death in 1986. This

award is presented to a graduating medical student who has demonstrated excellence in

physiology research and shows promise for a career as a medical scientist.

These awards are presented at the Ivy Day awards ceremony, which is the annual awards program for the School of Medicine held prior to graduation. On May 17, 2019, Andrew Curnow, mentored by Dr. Prieto, received the Hymen Mayerson award and Krishna Pandya, mentored by Dr. Pandey, received Nicholas Di Luzio award. Congratulations to the recipients for their outstanding research achievements.

HYMEN S. MAYERSON AWARD NICHOLAS R. DI LUZIO AWARD

Andrew C. Curnow Krishna Pandya



July 1, 2018-June 30, 2019 25

Summer Student Research

During the summer of 2018, the Department hosted eight summer research students. Drs. Majid,

Prieto, Sato, Lee, and Zsombok served as mentors. Students were supported by various funds

including the Bourgeois Family Endowment, the DeBakey Scholar Program, and Programs at LSU

Health Sciences Center and School of Veterinary Medicine.

2018 Summer Research Students

Marco Acosta Mentors: Dr. Minolfa Prieto

Sponsor: LSUHSC Undergraduate Scholarship

Research Project: Effects of prorenin receptor on the epithelial sodium channel in

M-1 cells

Peace Ekpo Mentor: Dr. Dewan Majid

Sponsor: LSU School of Veterinary Medicine - Louisiana Biomedical Research

Network (LBRN) Program

Research Project: Regulation of TNF-α receptors by nitric oxide in renal proximal

tubular cells

Jennifer Hong Mentors: Dr. Minolfa Prieto

Sponsor: Bourgeois Endowment

Research Project: Effects of Nebivolol and Valsartan on plasma and urine levels of

soluble prorenin receptor in hypertensive patients



July 1, 2018-June 30, 2019 26

David Le Mentor: Dr. Jean-Pyo Lee

Sponsor: DeBakey Scholar Program

Research Project: Effects of diabetes on vascular disease

Jose ‘Fernando’ Villamizar Mentor: Dr. Minolfa Prieto

Sponsor: Universidad led Norte de Santander, Columbia Scholarship

Research Project: Effect of prorenin receptor activation in the production of TNF-α

and IL-6 in macrophages

Cassidy Werner Mentor: Dr. Andrea Zsombok

Sponsor: Medical Student Volunteer

Research Project: Identification of subsets of neurons projecting from the

hypothalamus to both pancreas and interscapular brown adipose

tissue

Stacy Yanofsky Mentors: Dr. Ryo Sato

Sponsor: Bourgeois Endowment

Research Project: Role of Ang II in the development of iPSC-derived human kidney

organoids



July 1, 2018-June 30, 2019 27

For the summer of 2019, the Department will have 10 student researchers that will be supported

by BMS ASPIRE grants, the Bourgeois Family Endowment, DeBakey Scholars program and host

institutional funding. In addition, we will have 6 volunteer researchers. Drs. Solange Abdulnour-

Nakhoul, Dewan Majid, Olan Jackson-Weaver, Kailash Pandey, Minolfa Prieto, Ryosuke Sato, T.

Cooper Woods, Hongju Wu, Andrea Zsombok, and L. Gabriel Navar are serving as mentors.

Incoming 2019 Summer Research Students

Annie Bell, ASPIRE

(Dr. Navar)

Alexander Cao

Zhang, DeBakey

Scholar

(Dr. Wu)

Matthew

Hennrikus,

DeBakey Scholar

(Dr. Prieto)

Anna Hodges,

DeBakey Scholar

(Dr. Abdulnour-

Nakhoul)

Jennifer Hong,

Research Grant

(Dr. Prieto)

Mardeen Karim,

ASPIRE

(Dr. Jackson-

Weaver)

Stephanie

McNamara, ASPIRE

(Dr. Zsombok)

Chikaodilil Osuji,

LSU LBRN

(Dr. Majid)

Stacy Yanofsky,

Research Grant

(Dr. Sato)

Volunteer Research Students

Robert Drury,

Volunteer

(Dr. Jackson-

Weaver)

Maribeth Harlan,

Volunteer

(Dr. Jackson-

Weaver)

Mark Legendre

Volunteer

(Dr. Jackson-

Weaver)

Rudy Neustadt,

Volunteer

(Dr. Woods)

Valeria Noguera,

Volunteer

(Dr. Pandey)

Jacob Packer,

Volunteer

(Dr. Jackson-

Weaver)



July 1, 2018-June 30, 2019 28

5. VISITING SCHOLARS PROGRAM

Dr. Clinton Webb received his PhD from the University of Iowa in 1976, and completed a

Physiology Postdoctoral Fellowship in the Department of Physiology at the University of Michigan in

1978. Dr. Webb served as a research associate at the Universitaire Instelling Antwerpen in Antwerp,

Belgium from 1978 – 1979. He then returned to the University of Michigan where he remained for the

next 20 years rising to the rank of Professor. In 1999 he joined the Medical College of Georgia where

he served as the Robert B. Greenblatt Professor of Endocrinology and as Chair of the Department of

Physiology. Dr. Webb was named the Herbert S. Kupperman Chair in 2006 serving in the Departments

of Physiology, Surgery and the School of Graduate Studies. In 2011, Dr. Webb was named a Regents ’

Professor, a recognition representing the highest academic status bestowed by the University System of

Georgia. He also holds a secondary appointment as Professor of Pharmacology and Toxicology.

Over the years, Dr. Webb’s research has been funded by several agencies including the American Heart

Association (AHA), the National Institutes of Health (NIH) and various pharmaceutical companies. He

is currently Director and Project Leader on a multi-million dollar grant from NHLBI and PI on a Pilot

Program grant from NKDDK. His research interests include the physiology of vascular smooth muscle

with emphasis on vascular reactivity in hypertension and diabetes, penile and clitoral erection in sexual

dysfunction, mechanisms of bladder dysfunction in diabetes, cellular and subcellular mechanisms of

contraction and relaxation of vascular smooth muscle, adrenergic neurotransmission in blood vessels,

and intercellular communication between smooth muscle cells. His lab was among the first to establish

the importance of Rho kinase, or ROCK, in erectile dysfunction and his work has helped explain how

2019

Mayerson-Di Luzio

Annual Lectureship



July 1, 2018-June 30, 2019 29

reactive oxygen species, which stimulates ROCK, may affect

vascular function. His lab also was among the first to identify a

role for damage-associated molecular patterns and innate

immune responses in hypertension.

Dr. Webb is a member of numerous societies including the

American Physiological Society’s Cardiovascular and Cell and

Molecular Physiology Section and he chairs the Awards

Committee of the Cardiovascular Pharmacology Division,

American Society for Pharmacology and Experimental

Therapeutics. He served as Chair of the Council for High Blood

Pressure Research, and as a member of the association’s

Ethnicity and Gender Working Group, Strategic Planning

Committee and International Mentoring Program. Dr. Webb

also served as Chair of the Association of Chairs of

Departments of Physiology, 2009-2010. He has published over

450 peer-reviewed papers and scientific reviews. Dr. Webb

serves on numerous editorial boards and is associate editor for

the American Journal of Hypertension and Pharmacological

Research. He is also a Guest Editor for the journal,

Hypertension, and a Contributing Editor to the Journal of the

African Association of Physiological Sciences.

Dr. Webb has received several awards including the inaugural

Bodil M. Schmidt-Nielsen Distinguished Mentor and Scientist

Award from the American Physiological Society’s Women in

Physiology Committee in 2004. He received the Carl J. Wiggers

Award from the cardiovascular section of the American

Physiological Society in 2012 and the AstraZeneca Award from

the International Society for Hypertension in 2012. In 2013, he

received the Irvine Page and Alva Bradley Lifetime Achievement

Award from the Council for Hypertension, AHA. Dr. Webb

received the 2015 Georgia Regents Research Institute Lifetime

Achievement Award. In 2016, he became a fellow of the

American Society of Hypertension and in 2017 received the

Distinguished Research Award from the Graduate School at

Augusta University. Dr. Webb gave the Inaugural Sibley

Hoobler Lecture in 2017 at the Frankel Cardiovascular Center,

University of Michigan. Most recently, he received the 2018

Excellence Award in Hypertension Research from the Council

on Hypertension of the AHA.



July 1, 2018-June 30, 2019 30

Extramural Physiology Seminars

July 23, 2018

Licy Lorena Yanes Cardozo, MD

Associate Professor

Department of Cell and Molecular Biology

University of Mississippi Medical Center

Jackson, MS

“Cardiometabolic complications in Polycystic Ovary

Syndrome”

September 24, 2018

Joint Physiology & Medicine

Conference

Noah Shroyer, PhD

Associate Professor


Section of Gastroenterology & Hepatology

Baylor College of Medicine

Houston, Texas

“Plasticity and quiescence of intestinal stem cells:

implications for regeneration and cancer”

October 15, 2018

Jointly Sponsored by THRCE (8:30am)


Conference (12:00 noon)

James D. Stockand, PhD

Professor, Cellular & Integrative Physiology

Director, Pathobiology of Occlusive

Vascular Disease Fellowship Program

University of Texas Health Science Center

San Antonio, TX

“Enabling Curiosity to Expand Scientific Expertise” (8:30am)

“Disruption of Purinergic Control of Sodium

Excretion Intrinsic to the Distal Nephron Causes

Salt-Sensitive Hypertension” (12:00 noon)

Department of physiology seminar series



July 1, 2018-June 30, 2019 31

October 22, 2018

David E. Stec, PhD

Professor

Department of Physiology & Biophysics

Director of Transgenic Core


Jackson, Mississippi

“Bilirubin and Biliverdin Reductase in Metabolic

Disease”

December 3, 2018


Conference

Harry Pothoulakis, MD

Director: Basic Research, UCLA Center for

Inflammatory Bowel Diseases

Professor of Medicine, Pathology and Laboratory

Medicine

UCLA

Los Angeles, CA

“Substance P – Induced exosomal regulation of

colitis”

January 28, 2019

Rafael Rubio, Ph.D. Professor Emeritus


University of Virginia

Charlottesville, VA.

Universidad Autonoa de San Luis

Potosi, San Luis, Mexico

Visiting Professor


Tulane University School of Medicine

New Orleans, LA

“The Epigenetics: Linking Salt to the Brain Renin-

Angiotensin System”

February 11, 2019


Conference

Yingzi Cong, PhD

Professor of Medicine

Department of Microbiology &

Immunology and Pathology

University of Texas Medical Branch

Galveston, TX

“Host-microbiota interaction in

regulation of inflammatory bowel diseases”



July 1, 2018-June 30, 2019 32

February 18, 2019

Robert L. Hester, PhD

Professor

Department of Physiology, Data Sciences &

Orthopedic Surgery


Jackson, MS

“Mathematical Modeling for Understanding

Physiological Responses”

February 25, 2019

Antoine Chaanine, MD

Assistant Professor of Medicine

Division of Adv HF & Transplant Cardiology

Department of Cardiovascular Disease

Mayo Clinic School of Medicine

Rochester, Minnesota

“Novel Insight in the Pathophysiology of Heart

Failure. Role of the FOXO3a-BNIP3 Pathway”

March 5, 2018

2018 Mayerson-DiLuzio

Lectureship

Jointly Sponsored THRCE

R. Clinton Webb, PhD

Kupperman Chair in Cardiovascular Disease

Regents’ Professor


Medical College of Georgia

Augusta University

Augusta, Georgia

“Mitochondria-derived DAMPs as a

trigger of innate immune responses

and vascular inflammation in

hypertension”

March 18, 2019

Special School Wide Grand

Rounds

W. Marcus Lambert, PhD

Assistant Dean of Diversity and Student Life

Assistant Professor of Education Research in

Medicine

Weill Cornell Medicine

New York City, NY

“Inclusive Excellence: Breaking down barriers to

success and recognizing your greatest potential”



July 1, 2018-June 30, 2019 33

March 25, 2019

Heather A. Drummond, PhD

Professor


Director, Confocal Microscopy Facility &

Director, Histology Core


Jackson, Mississippi

“Vascular Degenerins in Renal Hemodynamics”

April 1, 2019


Conference

Arthur Beyder, MD

Consultant, Gastroenterology & Hepatology

Assistant Professor

Department of Medicine & Physiology &

Biomedical Engineering

Mayo Clinic Rochester

Rochester, MN

“The molecules and mechanisms that makes

irritable and slow colons”

April 29, 2019

Qinglin Yang, PhD

Professor of Pharmacology

Cardiovascular Center of Excellence

LSU Health New Orleans

New Orleans, LA

“Targeting metabolic dysfunction in the diseased

heart”

June 24, 2019

Jointly Sponsored THRCE

Krisztian Stadler, Ph.D.

Associate Professor-Research

Oxidative Stress and Disease Laboratory

Pennington Biomedical Research Center-LSU

Baton Rouge, LA

“Mitochondrial substrate overload and chronic

kidney disease”



July 1, 2018-June 30, 2019 34

Extramural THRCE Conferences

August 23, 2018

Chih-Hong Wang, Ph.D. Assistant Professor

Department of Biological Sciences & Technology

National Chiao Tung University

Hsichu, Taiwan

“Inhibition of renin angiotensin system causes severe anemia due to hypothyroidism”

October 15, 2018*

Jointly Sponsored by

Physiology (8:30am)

Joint Physiology &

Medicine Conference (12:00

noon)

James D. Stockand, Ph.D. Professor, Cellular & Integrative Physiology

Director, Pathobiology of Occlusive

Vascular Disease Fellowship Program

University of Texas Health Science Center

San Antonio, TX

“Enabling Curiosity to Expand

Scientific Expertise” (8:30am)

“Disruption of Purinergic Control of Sodium Excretion Intrinsic to the Distal Nephron Causes Salt-Sensitive Hypertension” (12:00 noon)

November 15, 2018*

Jointly Sponsored by the


1:00PM

Jonathan Himmelfarb, MD Professor, Division of Nephrology

Director, Kidney Research Institute

Director, Center for Dialysis Innovation

University of Washington

Seattle, WA

“Hypertension, renal disease and cancer”

T.H.R.C.E.

Tulane Hypertension & Renal Center of Excellence

Extramural THRCE Conference Speakers



July 1, 2018-June 30, 2019 35

May 16, 2019*

Jointly Sponsored by the

Department of Pediatrics

2:00PM

Leif Oxburgh, DVM, PhD Faculty Scientist III (Full Professor),

Maine Medical Center Research Institute

Center for Molecular Medicine

Professor, Tufts University School of Medicine

Scarborough, Maine

“Understanding the niche that controls nephron specification”

June 13, 2019

Snezana Petrovic, MD Assistant Professor

Section of Gerontology and Geriatric Medicine

Department of Internal Medicine

Wake Forest School of Medicine

“Dietary acid load, kidney function and disability in older adults: Current evidence and future directions”

June 24, 2019

Jointly Sponsored by

Physiology

Krisztian Stadler, Ph.D.

Associate Professor-Research

Oxidative Stress and Disease Laboratory

Pennington Biomedical Research Center-LSU

Baton Rouge, LA

“Mitochondrial substrate overload and chronic

kidney disease”

*Not on our regular scheduled day and/or time



July 1, 2018-June 30, 2019 36

6. FUTURE DIRECTIONS

Research The main priority for the coming years is to further improve the research funding base of the

Department by having all faculty seek and obtain additional extramural funding. The department

will make maximum effort to assist all faculty members in their efforts to obtain and hold

extramural research support from NIH and other funding agencies. In view of the challenging

times, funding opportunities from many sources must be sought including industry, AHA, ADA,

NSF, VA and any other agency, foundation or society that provides funding for our areas of

research. Department policy encourages sabbatical research leave for qualified faculty to

provide an opportunity to review current research trends and to maintain up-to-date modern,

competitive research programs. Faculty are also encouraged to present their work at national

and international meetings and publish their studies in highly regarded peer reviewed journals.

Get your finding to print as soon as possible. Data are not lie wine, they don’t get better with

age.

Special Aims for the New Fiscal Year:

Enhance and expand our ongoing studies and future research with more translational

approaches to compete for NIH funding. Increase the number and depth of our publications.

Assist all faculty in obtaining and increasing their extramural research funding by enhancing

infrastructure support and procuring recently developed instrumentation.

Transition from relying on the financial support provided by the COBRE and encourage

optimization of each research group by synergistic collaborations with other faculty members

within and outside of our department. Encourage multi-PI and program project proposals.

Continue efforts to improve faculty salaries to make them competitive with those at our peer

institutions.

Integrate individual research focus areas of our faculty (cardiovascular, renal, endocrine and

neurophysiology) into larger cross-disciplinary research programs.

Enhance the funding of the Hypertension and Renal Center of Excellence by recruiting a

well-recognized senior investigator who is robustly funded with 2 RO1 or more grants as the

new Director of the Center and also increase the interdisciplinary profile of the Center as a

University-wide Center of Excellence supported at the University level.



July 1, 2018-June 30, 2019 37

Education The education priorities for the department will be to enhance the quality of the Physiology

course lectures and improve recruitment of both MS and PhD graduate students. Emphasis will

be placed on the development of stimulating medically relevant interactive sessions as we move

towards an integrated curriculum. The Department will seek better ways to participate in the

combined program in biomedical sciences so that we can recruit superior graduate students.

We also plan to develop or improve graduate student courses in techniques of molecular

physiology, principles of molecular transport, renal physiology, and microcirculatory physiology.

The overall effort in graduate student recruitment has been improving because of increased

stipend amounts and the decision to cover mandatory fees. A special task force has been

appointed to review our current procedures in graduate student recruitment and to design and

implement mechanisms that will increase the number of highly competitive graduate students in

our program. The improvement of our graduate student recruitment procedures is a very high

priority for the department. Faculty should consider applying for training grants in specific areas

of interest to NIH institutes.

The Masters in Medical Physiology is a post-baccalaureate program designed for students with

a bachelor degree (BS or BA) in a Chemical/ Physiological/ Biological discipline or pre-medical

program. Students seeking advanced training in the physiological sciences, typically in

preparation for admission to a professional medical program, PhD program, or planning to work

in academia, government, industry or biotechnology sectors will benefit from this program.

Future Goals:

Improve the Human Physiology Course by adding more interactive teaching methods

(e.g., clicker questions) and tutorial sessions during lectures and having tutorial sessions

to instruct the faculty in these methods.

Increase the number of nationally recognized visiting scientists presenting at our seminar

program.

Improve the courses developed for our MS in physiology program.

Service and Administrative Responsibilities:

Increase community involvement by developing programs for involvement of high school

and undergraduate students in Physiology research and by sponsoring STEM related

activities and workshops in K-12 schools and undergraduate colleges.

Encourage all faculty to volunteer for elected positions of the General Medical Faculty

and University –wide positions.



July 1, 2018-June 30, 2019 38

7. FACULTY AND STAFF

Physiology Organizational Structure

The organizational structure consists of the chair and eleven standing committees. Faculty input for

departmental decisions is solicited at monthly faculty meetings.

Biomedical Engineering &

Undergraduate Liaison Committee

Library and Educational

Aids/Website Committee

Molecular Core/ Facilities & Space

Committee

Medical Education Committee

Funding Opportunities Committee Neuroscience Interest Group

Graduate Studies Committee Promotions and Tenure Committee

Happiness and Well Being Committee Renal & Vascular Workshop Committee

Seminar Committee

There were 13 faculty members during 2018-19 fiscal year. These faculty are complemented by the

additional 9 adjunct faculty whose primary appointments are in other departments or other

institutions. There are 8 adjunct faculty who hold a PhD degree and have their primary appointment

in a clinical department who are listed under our regular faculty and are given equal consideration

as regular faculty in departmental governance. The distribution of primary faculty ranks is listed

below:

5 professors 11 associate professors 4 assistant professors 1 instructor



July 1, 2018-June 30, 2019 39

Research Focus

Mechanisms responsible for regulating renal hemodynamics, glomerular filtration rate and sodium excretion; experimental hypertension; renin-angiotensin system

Awards – Honors – Recognition

Honored with the “L. Gabby Navar

Symposium” to celebrate 30 years as Chair of the Department of Physiology at Tulane. The symposium speakers consisted of past and present trainees, many of whom now hold prominent positions. The symposium was held on October 5, 2018.

Grant Awards Janssen Scientific Affairs, LLC:

28431754DIA4010 (PI) Role of Kidney production of AGT in the reduction of BP by SGLT2 Inhibition under diabetic and non-diabetic conditions (12/18/15-09/30/18)

NIH - NIGMS: 1P30GM103337 (PI)

Translational Research in Hypertension and Renal Biology (08/01/12 – 07/31/19)

NIH - NHLBI–University of Virginia:

Subaward No GB10298-01A1(PI) MD-INMD-EN Renal AT2 Receptors in Hypertension (04/01/16-03/31/21)

NIH – NIDDK - NRSA: 1F31DK121445 PI: Owen Richfield, Graduate Student (Mentor) Predoctoral Fellowship entitled, “A Computational Fluid Dynamics Model of Glomerular Microvascular Mechanics” (07/01/18-06/30/20)

CLB (Carol Lavin Bernick) Faculty Grant (PI)

Project with Postdoctoral Fellow, Supaporn Kulthinee entitled, “Interactions between purinergic receptors and angiotensin II receptors in regulating renal microcirculation in angiotensin II hypertension” (05/01/2018-06/30/2019)

CLB (Carol Lavin Bernick) Faculty Grant (PI)

Project with Graduate Student, Owen Richfield entitled, “A computational biomechanics model of the rat glomerulus to evaluate risk of mechanical insults in

L. Gabriel Navar, Ph.D.

Professor and Chair Director, COBRE;

Hypertension and Renal Center of Excellence

University of Mississippi, 1966 .



July 1, 2018-June 30, 2019 40

pathophysiological hemodynamic conditions” (05/01/2019-06/30/2020)

Invited Lectures

Invited Speaker –Medical College of

Wisconsin, Cardiovascular Center, Wisconsin. “Regulation of the intrarenal renin-angiotensin system in hypertension and diabetes” September 26, 2018.

Invited Speaker – Texas Tech University,

Health Sciences Center, El Paso, Texas. “The intrarenal renin-angiotensin system in development off hypertension” February 12-13, 2019.

Invited Speaker - 2nd Pan American Physiological Sciences Congress that took place in Havana, Cuba from May 27-31, 2019.

National and International

Prominence

Editorial Boards American Journal of Hypertension, 1999 -

present American Journal of Medical Sciences, 2006-

present; Guest Editor, 2010 Annals of Clinical and Experimental

Hypertension, 2013-present BLDE University Journal of Health Sciences,

International Editorial Adviser, 2016-present

Current Hypertension Reviews, 2016-present Enliven: Nephrology and Renal Studies, 2018-

present Hypertension, Consulting Editor, 2006 –

present International Journal of Cardiology:

Hypertension, 2018-present International Journal of Nephrology and

Renovascular Disease, 2009 - present Journal of Clinical Hypertension, 2012 -

present Journal of American Society of Hypertension,

2007 – 2018 Physiology International, 2001 - present

Review Service

Abstract Reviewer:

American Heart Association American Physiological Society:

Undergraduate Research Summer Program

Grant Reviewer: Dutch Kidney Foundation

Journal Reviewer: American Journal of Physiology: Renal

Physiology Clinical Science Hypertension Journal of the American Society of

Nephrology Journal of Physiology Kidney International Nature Communications Science Translational Medicine

Other Professional Positions and

Services

FAHA, American Heart Association FAPS, American Physiological Society FASN, American Society of Nephrology FASH, American Society of Hypertension Member, APS Distinguished Physiologist

Committee, 2018-2020

Dr. Cowley (left) and Dr. Navar (right)

during his visit to MCW



July 1, 2018-June 30, 2019 41

Research Focus

Gastroenterology; cellular ion transport;

intracel lular pH regulation; ion

transport in epithelia


Grant Awards

Tulane Bridge Research Award –

2018-2019 (Co-PI) Ammonia

Transport and Acid-Base

Homeostasis” , $30,000

DCI, Paul Teschan Research Fund,

(Co-PI) 02/01/19-01/31/21,

“Ammonium transport in acidosis and

chronic kidney disease” $120,000


Prominence

Review Service

Journal Reviewer: Experimental Physiology

Journal of Rare Diseases Research &

Treatment

World Journal of Gastroenterology

Other Professional Positions

and Services University level Chair, VA IACUC Committee

Member, Tulane Medical School

Admissions Committee

Member, Tulane IACUC Committee

National level

Fellow, AGA

Member, American Physiological Society

Solange Abdulnour-Nakhoul, Ph.D.

Adjunct Associate Professor American University of Beirut, 1983

Research funded by VA grant



July 1, 2018-June 30, 2019 42

Research Focus

Neuroscience: Central control of

cardiovascular functions


Grant Awards

Received an NIH -LSU SPARC

(Stimulating Peripheral Activity to

Relieve Conditions) grant. This award

is part of the initiative with

Pennington Biomedical Research

Center. The subaward is entit led,

“Genetically based neuro -modulation

of adipose t issue function ”

NIH NHLBI 122829 (role: PI) , 08/15/2015-05/31/2019 Tit le: Sympathetic control and hypertension via brainstem cannabinoid s ignaling

National/International

Prominence

Review Service

Journal Reviewer:

Hypertension Journal of Physiology (London)


and Services

Departmental Level

Member, Masters ’ Program

Committee , 2014-Present

University Level

Executive Board Member, Tulane

University, Brain Insti tute , 2016-

Present

Director, PhD Program in

Neuroscience, Tulane University,

School of Science and Engineering

Admission Committee, Neuroscience

PhD Program, 2017-Present

Tulane University, School o f

Medicine, Grievance Committee,

2017-2020

National Level

2018-Pres The American

Physiological Society, Chair for the

Award Section of the Central Nervous

System Committee

2018-Pres The American

Physiological Society, Career

Opportunities in Physiology

Andrei Derbenev, Ph.D.

Associate Professor Pavlov Institute of Physiology, Russia, 1999

Research funded by NHLBI



July 1, 2018-June 30, 2019 43

Research Focus

Regulation of renal tubule epithel ial transport and acid-base homeostasis via physiological , molecular and metabolic mechanisms. Our current emphasis is on regulation of ci trate transport and metabolism Awards – Honors – Recognition

FASN, Fellow of the ASN

Grant Awards

DCI Paul Teschan Career Development Grant “Pleiotropic Effects of Citrate Transporter NaDC1” (Role: PI), 02/01/2018-01/31/2019 $60,000/yr


Prominence

Editorial Boards

AJP: Renal (2013-present)

Review Service

Journal Reviewer:

Ad Hoc Reviewer for Journal of Diabetes and

Its Complications

Ad Hoc Reviewer for American Journal of

Medical Sciences

Ad Hoc Reviewer for Canadian Journal of

Physiology and Pharmacology

Ad Hoc Reviewer for BMC Journal of Nutrition

AJP Renal

International Journal of Molecular Sciences

Kidney International


and Services

Departmental level Medicine/Nephrology Core Director Tulane University Department of Medicine

Departmental Safety Representative Department of Physiology Graduate Studies

Committee & MS Program Department of Physiology Funding

Opportunities Committee

University level Tulane SOM Deans’ Faculty Advisory

Committee Tulane University SOM Faculty Senator

(Elected) 2017-2020 Director of Tulane SOM Freezer Farm

National level

American Physiological Society Renal Section Secretary (Elected) 2016-2019

Southern Society for Clinical Investigation Councilor, Elected 2018-2021

SSCI Governance Committee (Elected) 2016-2019

American Society of Nephrology Kidney Stars Mentor 2015-

Teaching: Physiology Department

Huma n Phys iol ogy : PBL

M edic al Physiol ogy -R ena l Phys iol ogy

Tra ns port

R ena l Phys iol ogy – Proxima l Tubul e

DOM A ging C enter

A G ST 7060 Topic s in Aging R es ea rc h

A G ST 7040 A ging a nd the Kidney

Kathleen S. Hering-Smith, MS, PhD, FASN

Adjunct Associate Professor Tulane University, 2004

Research funded by NIDDK, COBRE, LA CaTS



July 1, 2018-June 30, 2019 44

Research Focus

We study several aspects of endothelial

cel l biology, including endothelial cel l

damage during shock and trauma and

the role of Ca2+ signaling modalit ies in

the regulation of angiogenesis .


Grant Awards

American Heart Association Career Development

Award: 19CDA34660287

“Arginine methylation of IP3 receptors in NFAT

signaling and angiogenesis”

PI: Olan Jackson-Weaver

3 years, $231,000

04/01/2019- 03/31/2022


and Services

2007-present Member, American

Heart Association

2007-present Member, American

Physiological Society

LAB MEMBERS

Sarah Abdullah

G r a du a te S tu de n t

Robert Drury

S u mm e r M e d i ca l

S tu d en t

Maribeth Harlan


S tu d en t

Mardeen Karim


S tu d en t

Mark Legendre

S u mm e r Und e rg r adu a te

S tu d en t

Jacob Packer


S tu d en t

Olan Jackson-Weaver, Ph.D.

Adjunct Assistant Professor University of New Mexico, 2012

Research funded by AHA



July 1, 2018-June 30, 2019 45

Research Focus

Neurophysiology; electrophysiological

and metabolic relationships in brain

t issue; Pathophysiology of epilepsy and

anoxia/ischemia


2019 Tulane University SOM Owl Club,

T1 Best CBL Facili tator Award


and Services

Co-Director, Tulane Medical School T2-Course: Brain, Mind, and Behavior

Chair, Promotions and Tenure Committee, Department of Physiology, Tulane University

Faculty Co-Advisor for the T4 UpTOBAT

Elective Course

Norman R. Kreisman, Ph.D.

Professor Vice-Chair

Medical College of Pennsylvania, 1971 Research funded by Developmental Funds



July 1, 2018-June 30, 2019 46

Research Focus

Molecular biology and aspects of

genetics and reproduction in non -human

primates


Grant Awards

NIH/OD-U42 OD010568 (James Blanchard, PI)

Role: Co-Investigator

Maintenance of an SPF Macaque Breeding Colony

for AIDS Research, 08/09/01 – 01/31/21

NIH/U24 OD011109/OD-U42 OD024282 (Rudolf

Bohm, PI) Role: Co-Investigator

Tulane National Primate Research Center, AIDS

SPF Breeding Colony Maintenance, 09/30/02 –

06/30/21


Prominence

Editorial Boards

Associate Editor: Reproduction, Fertility,

Development

Review Service

Journal Reviewer:

Journal of the American Association for

Laboratory Animal Sciences

Journal of Medical Primatology


and Services

Chair , Tulane University IACUC

Advisory Committee

Member and Alternate Chair , TNPRC

IACUC

Member, National Primate Research

Centers Consortium “New Model

Development Working Group”

Member, National Primate Research

Centers Consortium “Genetics and

Genomics Working Group”

Hans Michael Kubisch, Ph.D.

Associate Professor University of Guelph, Canada, 1992

Research funded by NIH



July 1, 2018-June 30, 2019 47

Research Focus

Molecular mechanisms governing the

regulation of natriuretic peptide

receptor expression

Invited Lectures

Physiology Seminar Series, Tulane

University SOM, “ Inhibit ion of HDAC

activity Blocks NF-ΚB and Suppresses

the Renal Inflammation and Fibrosis in

Npr1 Haplotype Mice ” December 17,

2018.


and Services

Departmental Level

2014-Pres Member, Facil it ies and

Space Committee

University Level

Senior Division Judge, New Orleans

Science and Engineering Fair , Tulane

University Lavin-Bernick Center, New

Orleans , LA, Feb 20, 2019

Judge, Tulane University Health

Sciences Research Days , New Orleans,

LA, March 18-19, 2019

National Level

2007- Pres: Member, The American

Heart Association (AHA)

2006- Pres: Member, The American

Society for Biochemistry and

Molecular Biology (ASBMB)

Judge, 22st annual American Society

for Biochemistry and Molecular

Biology Undergraduate Poster

Competition, San Diego CA, Saturday,

Apri l 6, 2019

Prerna Kumar, Ph.D.

Instructor Jawaharlal Nehru University, New Delhi, India, 2004

Research funded by NHLBI



July 1, 2018-June 30, 2019 48

Research Focus

Stem cell therapies involving molecular biology,

biochemical techniques and stem cell

transplantation that target the central nervous

system.


Tulane Bridge Research Award – 2018-2019,

(Role: PI) “Combination of Antithrombotic Drug

and Neural Stem Cells for Treating Stroke”

NIH NINDS R01NS110370-01 (Role, PI)

“Combination treatment of ischemic stroke with

perlecan DV and neural stem cells” (Dec 2018-Nov

2023)


Prominence

Moderator and Poster Professor, International Stroke Conference (ISC), Vascular Cognitive Impairment: Moderated Poster Tour, Feb. 7. 2019 Editorial Boards

AJP Heart Circ Physiol , 2019 -Present Scienti fic Reports, 2018 -Present Experimental Neurology, 2018 -

Present; Guest Editor 2019 -present

Review Service

Abstract Reviewer:

Arteriosclerosis, Thrombosis, and

Vascular Biology (ATVB/PVD) Scientific

Sessions, 2019

International Stroke Conference (ISC),

2019

Grant Reviewer:

American Heart Association (AHA) Grant

Peer Review Study Section (Vascular

Endothelial Biology basic), Spring, 2019

NIH, Brain Injury and Neurovascular

Pathologies (BINP) Study Section,

Chicago, Oct 2018; Feb 2019; June, 2019

Journal Reviewer:

American Journal of Physiology: (AJP)-Cell Physiology, 2018, 2019

American Journal of Physiology: (AJP)-Heart Circulatory Physiology, 2018, 2019

Journal of Applied Physiology, 2018 Journal of Neurophysiology, 2019 Stem Cell Research & Therapy, 2018,

2019 Stem Cells Translational Medicine, 2019


and Services

Interviewer: Tulane Medical Student Admissions, 2013-present

Seminar Committee: Department of Physiology, Tulane University, 2018

Jean-Pyo Lee, Ph.D.

Assistant Professor University of Chicago, Chicago, IL, 1998

Research funded by Salem Science Charitable Trust, Departmental Funds



July 1, 2018-June 30, 2019 49

Research Focus

Development of antitumor/hypoglycemic

drugs and ion channels and diseases


Distinguished Professor of Kunming

University, China

Invited Lectures

Conference speaker — Science and Technology Association, Kunming, Yunnan, China. “New Type of Drug for Treatment of Type -2 Diabetes” , July 2018

Invited Seminar Speaker – College of Medicine of Inner Mongolia, Huhhot, Inner Mongolia , China . “T-type Ca Channel Inhibitors For Treatment of Type 2 Diabetes Melli tus”, June 2019


Prominence

Editorial Boards

• Asia-Pacific Journal of Medicine Editor 2018-present

• Clinical Medicine Research Editor 2018-present


and Services

Department Level

Director, Graduate Student Program, Department of Physiology, Tulane University SOM

University Level

Director, Quantitative Physiology Course, Tulane University

Member, BME & Undergraduate

Liaison Committee, Tulane University

Ming Li, PhD

Associate Professor Director of Graduate Studies

Director of Quantitative Physiology Course University of Iowa, 1989

Research funded by Development Funds, LBOR



July 1, 2018-June 30, 2019 50

Research Focus

Renal hemodynamics and renal function;

integrative role of endothelium derived

vasoactive substances; salt sensitive

hypertension


Organized the National Convention of

Bangladesh Medical Association in

North America (BMANA) held in New

Orleans , LA, July 2018 as the

Chairman of the Convention

Welcoming Committee. BMANA is a

professional organization of

Physicians from Bangladesh origin in

North America (USA & Canada)

Grant Awards

Tulane CLB (Carol Lavin Bernick)

Faculty Grant (PI)


Prominence

Editorial Boards

Al-Ameen Journal of Medical Sciences,

India, 2007-present

Anti-oxidant Journal – Special Edition Editor, 2016 -present

Bangladesh Physiology and Pharmacology Journal , 2008 -present

BLDE University Journal of Health Sciences, India , 2015 -present

Journal of Clinical and Experimental Pharmacology and Physiology, 2006-present

Pakistan Journal of Physiolog y, 2008-present

Sylhet Osmani Medical Col lege Journal , Bangladesh 2013-present

Review Service

Abstract Reviewer: AHA Hypertension Conference, 2019

Grant Reviewer: American Heart Association Grant Review

Committee (Cardio-Renal, Basic Science Committee # 2)

Journal Reviewer: American Journal of Physiology: Heart

and Circulatory Physiology

American Journal of Physiology: Renal, Fluid & Electrolyte Physiology

American Journal of Physiology: Regulatory, Integrative Physiology & Biophysics

American Journal of Hypertension

Dewan SA Majid, MD, PhD

Professor University of Leeds, U.K. (PhD), 1989

University of Chittagong, Bangladesh (MD), 1978 Research funded by NHLBI, Bridge Funding, NIH CoBRE



July 1, 2018-June 30, 2019 51

Free Radical Biology and Medicine

Hypertension


and Services

Departmental level Chair, Physiology Seminar Series

Committee, Department of Physiology

Member, Physiology Graduate Students Program Committee

University Level University Senator International Level Appointed as Visiting Pr ofessor of

Medicine in the B. M. Patel Medical Col lege, BLDE University, Bi jayapura, Karnataka, India, 2017 -2019

Chair , Welcoming Committee that

organized the National Convention of

Bangladesh Medical Association in

North America (BMANA) held in New

Orleans from 26-29 July, 2018.

Dr. Dewan Majid during a preparatory

meeting with officials and hotel

management at the Sheraton Hotel for

the BMANA Convention.



July 1, 2018-June 30, 2019 52

Research Focus

Renal physiology; renin angiotensin

system; hypertension


2019 Tulane University SOM Owl Club

o Nominated for T1 Best Course


Prominence

Review Service

Abstract Reviewer: AHA; AHA Council on Hypertension

Grant Reviewer:

AHA Southeast Affiliate, Cardiorenal 1 Committee, 2013-2017

Journal Reviewer:

American Journal of Physiology


and Services

Course Director, Human Physiology Course, Tulane Univ. S OM, 2017-present .

Chair , T-1 Curriculum Subcommittee, Tulane University SOM, 2014-Present .

Course Director, Graduate Renal Physiology Course, Tulane Univ ersity SOM, 1992-present .

Director, The DeBakey Scholars Program, Tulane University SOM, 2009-present .

Member, Curriculum Committee, Tulane University SOM, 2011-present .

Member, Evaluations Subcommittee, Tulane University SOM, 2016-2018.

Member, LCME-CQI Committee, Tulane University SOM, 2016-2019.

Member, LCME-CQAI Subcommittee, Tulane University SOM, 2016-2019.

Chair , Medical Education Committee, Department of Physiology, Tulane University SOM, 2017-present.

Member, Medical Education Management Team Committee, Tulane University SOM, 2014-Present.

Member, Milestones Subcommittee, Tulane University SOM, 2016-2018.

Member, Promotions and Honors Committee, Department of Physiology, Tulane University SOM, 2012-present .

Member, Student Affairs Committee, Tulane University School of Medicine, 2017-present .

Kenneth D. Mitchell, PhD

Professor Director, DeBakey Scholars Program

University of Edinburgh, 1986 Research funded by NIGMS, Bridge Funding



July 1, 2018-June 30, 2019 53

Research Focus

Nephrology; cel lular ion transport;

intracel lular pH regulation; ion transport

in epithelia


Tulane Bridge Research Award – 2018-2019,

(Role: PI) Ammonia Transport and Acid-Base

Homeostasis”, $30,000.00

DCI , Paul Teschan Research Fund ,

02/01/2019 -01/31/2021, (Role: PI)

Ammonium transport in acidosis and

chronic kidney disease. $120,000

Invited Lectures

Invited Speaker, Epithel ial Physiology

and Cel l Biology Meeting, Tel luride, CO,

“Regulation of renal ammonia

transporters” , July 2018

Invited Seminar Speaker, Case Western

Reserve University , Department of

Physiology , “Properties and regulation of

renal ammonia transport by Rh

glycoproteins” , Jan 2019

Lab Members

Zhou He, Graduate Student


Prominence

Review Service

Journal Reviewer:

American Journal of Physiology: Cell

American Journal of Physiology: Renal

Journal of Physiology

Physiological Reports

Physiological Reviews


and Services

Departmental level :

Member, Graduate Committee, TUSOM


Member, Seminar Committee, TUSOM


University level :

Member, Tulane IBC Committee

Member, Tulane BMS Curriculum Committee

Secretary, Tulane General Faculty Committee

National level :

Member, American Association for the

Advancement of Science

Member, American Heart Association: Kidney

Council

Member, American Physiological Society

Member, American Society of Nephrology

Nazih L. Nakhoul, PhD

Adjunct Associate Professor American University of Beirut, 1983

Research funded by VA Grant, NIH



July 1, 2018-June 30, 2019 54

Research Focus

Molecular basis of hypertension, atrial

natriuretic peptides and receptors , renin

and angiotensin, cardiovascular

dysfunction, gene regulation and

genomics


Grant Awards

NIH R01 HL062147 grant NHLBI,

04/01/17-03/31/21 on the Study of

ANP Receptor : Gene Targeting and

Expression

Carol Lavin Bernick Faculty Research

Grant, 07/01/1 8-06/30/19

Invited Lectures

Invited Seminar Speaker, Department

of Medicinal Chemistry, School of

Ayurvedic Medicine, Insti tute of

Medical Sciences, Banaras Hindu

University, Varanasi , India . Dec. 1,

2018.


of Li fe Sciences, Amity Science,

Technology & Innovation Center,

Amity University, Noida -Delhi , India.

Dec . 6 , 2018.

Invited Guest Speaker, International

Symposium of Molecular Medicine,

Sanjay Gandhi Postgraduate Insti tute

of Medical Sciences (SGPGIMS) –

Lucknow, India . Dec . 15 , 2018

Invited Sem inar Speaker, Department

of Microbiology, Gargi Col lege, Delhi

University, Delhi , India . Apr . 24,

2019.

Kailash N. Pandey, PhD

Professor Vice-Chairman, Research

University of Kentucky, 1979 Research funded by NHLBI and NIGMS

Dr. Pandey presenting the guest lecture at

the International Symposium on Molecular

Medicine in Lucknow, India on Dec 15, 2018.



July 1, 2018-June 30, 2019 55


Prominence

Editorial Boards

Hypertension, 2018 - present

International Journal of Physiology, Pathophysiology and Pharmacology, 2012 – present

Journal of Blood Medicine, 2010 – present

Journal of Heart Disease, 2010 – present

International Journal of Biochemistry and Molecular Biology, 2011-present

Molecular Cellular Biochemistry, 2014 – present

Physiological Genomics, 2016 – present

Review Service

Abstract Reviewer: American Heart Association –

Hypertension Council Meeting, 2019

Grant Reviewer:

NIH/NHLBI, K23/K24, Special Emphasis Panel Study Section

Journal Reviewer:

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Cardiovascular Diabetology

FEBS Journal

Hypertension

International Journal of Molecular Sciences

Molecular and Cellular Biochemistry

Molecular Pharmacology

Physiological Genomics

PLOS ONE

Scientific Reports


and Services

Department Level

• Chair, Facilities and Space Committee, Department of Physiology, Tulane University School of Medicine

Member, Promotions and Honors Committee, Department of Physiology, Tulane University School of Medicine

University Level

Chair, Biomedical Sciences Graduate School Curriculum Committee, 2014-present

Faculty Mentor, Tulane Learning Communities

Judge, Tulane Research Day

International Level

Member, International Academy of Cardiology, 22nd World Congress on Heart Disease, Scientific Executive Committee, 2010 - present



July 1, 2018-June 30, 2019 56

Research Focus

Intrarenal regulation of RAS in

hypertension; Role of prorenin


Elected Co-Chair for the 2020 Gordon

Research Conference in Angiotensin

Laboratory Awards

Bruna Visniauskas , postdoctoral research

fellow, received the fol lowing awards:

A f inal is t for the Juan C a rl os R omero

Pos tdoc toral R es ea rc h R ec ognit ion

A wa rd for the Wa ter a nd E l ec trolyte

Homeos ta s is Sec t ion fr om A PS during the

E xperimenta l B iol ogy M eet ing in

Orl a ndo, FL in A pri l 2019.

The SSC I N ephrol ogy Young Inves t iga tor

Sc hola r A wa rd a t the Southern R egiona l

M eet ing of the A F MR in N ew Orl ea ns , L A

in F ebrua ry , 2019

The 2 n d F inal is t for the Three M inute

Thes is C ompeti t ion a t the E PI L i festy l e

2018 Sc ient i f ic Sess ions of the A HA hel d

in N ew Orl ea ns , L A in Ju l y 2018.

Grant Awards

NIH-NIDDK RO-1 (DK DK104375).

Role: PI . 09/22/2014 -09/30/2020

“Pleiotropic Effects of prorenin

receptor in the collect ing duct and

intrarenal RAS activation”

NIH-NCATSI: CCTS Multidisciplinary

Partner Network Pi lot Program,

04/01/2018-03/31/2019 “Cl inical

Impact of Plasma Soluble Prorenin

Receptor in Obese Type 2 Diabetic

Patients”

American Physiological Society

(APS): Research Enhancement Career

Award (RECA). Role: PI . 08/01/2018 -

07/31/2019. “ Sex di f ferences in the

Epigenetics Regulation of the RAS

using CRISPR-dCas9 technology”

Invited Lectures

Co-Chair and Invited Speaker , the V

International Symposium of the

Renin-Angiotensin System (RAS) held

in Sao Paulo, Brazi l , “Paracrine

regulation of collecting duct renin ” ,

August 5-7, 2018

Invited Speaker , Brazi lian Society of

Hypertension, San Jose of Rio Preto,

SP-Brazil . “Clinical relevance of

collecting duct renin in the

pathogenesis of hypertension ” , August

8-11, 2018

Minolfa Prieto, MD, PhD

Associate Professor Tulane University School of Medicine (PhD), 2004

Universidad del Zulia, Venezuela (MD), 1985 Research funded by NIGMS, LBOR, NIDDK



July 1, 2018-June 30, 2019 57


of Pharmacology & Toxicology, School

of Medicine, Virginia Commonwealth

University, Medical Col lege of

Virginia Campus , Richmond, VA, “PRR

and its Implications in CVD ” , April 23,

2019

Invited Speaker , Diabetes Research

Day. Sponsors LSU-Health Sciences

Tulane University, Pennington

Biomedical Research Center. Baton

Rouge, LA, “Sex dif ferences in the RAS

during hypertension, Type 2 diabetes

mell itus , and chronic kidney disease ” ,

May 3, 2019.

Invited Speaker , Workshop on

Experimental Animals: Practical tips

and Protocols , Insti tuto de Ciencias

Básicas y Preclinicas (ICBP) “Victoria

de Girón” de la Universidad de

Ciencias Médicas de La Habana as a

pre-meeting event of the 2nd Pan -

American Congress of Physiological

Sciences. Havana, Cuba. “Animal

models to assess renal physiology and

experimental hypertension ” , May 27,

2019.

Invited Speaker , Symposium on

Intracellular Angiotensin F orming

Mechanisms in Heart and Renal

Diseases: Myth or Reali ty during the

International Union of Physiological

Sciences (IUPS) 2nd Pan -American

Congress of Physiological Science.

Havana, Cuba, “Recent advanced in

the biology of the RAS in the distal

nephron during hypertension” , May

27-31, 2019.

Invited Symposium Chair and

Speaker, “Novel Thoughts Open New

Windows into the Function of the

Intrarenal RAAS in Cardiovascular

Diseases” IUPS 2nd Pan -American

Congress of Physiological Science.

“ Impact of the inte ractions of renin,

prorenin receptor, and soluble

prorenin receptor in cardiovascular

diseases” , Havana, Cuba, May 27 -31,

2019.


Prominence

Editorial Boards

American Journal Physiology, Renal Physiol,

2013-present

Biology of the Sex Differences Journal, 2011-present

Review Service

Abstract Reviewer: APS, Renal Section, EB 2019 APS, Water and Electrolytes Section, EB 2019 AHA, Council on Hypertension Meeting, 2019 Tulane Research Days 2019

Gordon Research Conference in Angiotensin

Grant Reviewer: NIH-HM Study Section. Regular Member

2017-2023

FAPESP, Foundation do Amparo a Pesquisa do Estado do Sao Paulo, Brazil

Journal Reviewer: American Journal of Geriatric

Pharmacotherapy

Biology of the Sex Differences Journal

American Journal of Physiology (Renal)

American Journal of Physiology (Heart and Circulatory Physiology)

Clinical and Experimental Pharmacology and Physiology

Clinical Therapeutics



July 1, 2018-June 30, 2019 58

Current Therapeutic Research

Gender Medicine

Hypertension

Journal of the American Society of Nephrology

Kidney International

PlosOne

Scientific Reports


and Services

Department Level :

Chair , Happiness and Well Being

Committee, Department of Physiology ,

2008-present

Member, Medical Education

Committee , 2008-present

Member, Physiology Graduate

Students Program Committee , 2008-

present

University Level :

Member, Admissions Committee ,

Tulane University SOM, 2007-present

Judge, Tulane Health Sciences Center

Research Days , 2007-present

Women’s Health-based Research

Committee , Tulane University SOM ,

2017-present

Member, Faculty Tenure, Freedom,

and Responsibil ity Committee (Senate

Subcommittee)

Member, Personnel and Honors (P&H)

Committee , 2017-present

National Level :

Member, KCVD Leadership Committee

of the Council on the Kidney in

Cardiovascular Disease , 2017-2019

Appointed Regular Member of the HM

Study Section, NHLBI/NIH , 2017-2023

Member, Executive Committee of the

Inter-American Society of

Hypertension (IASH), 2017-present

Co-Chair of the Symposium,

“Mechanisms of Hypertension -

Induced Kidney Damage” .

Experimental Biology Meeting,

Orlando, FL, April 7, 2019

International Level :

C ha ir of the Sympos ium , “N ovel Thoughts

Open N ew Windows in to the F unc t ion of

the Intra rena l R enin- Angiotens in Sys tem

in C a rdiovas c ula r Dis ea s es ” . 2nd Pa n

A meric a n C ongres s of Phys iol ogic al

Sc ienc es Ha va na , Cuba . M a y 27 - 31, 2019

E l ec ted C o- Cha ir for the Orga niza t ion of

the G ordon R es ea rch C onferenc e i n

A ngiotens in , to be hel d in L uc c a - Tusca ny ,

I ta ly , F ebrua ry 2020



July 1, 2018-June 30, 2019 59

Research Focus

Role of energy metabolism in nephron

progenitor cel l sel f -renewal and

nephrogenesis


Grant Awards

NIH RO1 DK118231 07/2018-06/2021,

“Intermediary Metabolism Control of

Nephron Progenitor Li fespan.”

Invited Lectures

Invited Speaker – Biomedicum Helsinki Seminar Series at the University of Helsinki. “Metabolic Control of Nephron Progenitor Cell Fate” October 15, 2018.


Prominence

Review Service

Abstract Reviewer:

Abstract Category Chair for American

Society of Nephrology (ASN) meeting,

‘Development, Stem Cells and Regenerative

Medicine’

Grant Reviewer:

Wellcome Trust/DBT India Alliance

Fellowship Grant Review

Journal Reviewer:

Nature Metabolism

Pediatric Nephrology


and Services

Professional Society Memberships:

American Association for the Advancement of

Science (AAAS)

American Society of Nephrology (ASN)

American Physiological Society (APS)

Institutional Responsibilities

Member, Department of Physiology, Admissions Review Comm ittee

Member, Faculty Advisory Committee

Member, Faculty Grievance Committee

LAB MEMBERS

J o rdan Huges

T 3 M ed i c a l S tu d en t

Francesca Edgington -

Gio rdano

G r a du a te S tu de n t

Giovane To r t e l o t e , PhD .

P o s tdo c to r a l F e l lo w

Mari e l Co lon-Leyva , MS

Re s e a r c h T e ch n ic i a n

Zubaida Saifudeen, Ph.D.

Adjunct Associate Professor Tulane University School of Medicine, 1997

Research funded by NIGMS, NIDDK



July 1, 2018-June 30, 2019 60

Research Focus

The inf luence of oxygen on the promotion

of l imb regeneration and t issue, muscle

and bone salvage after a traumatic injury.


Grant Awards

NIGMS, PI : Jazwinski , Role: Project Leader, 2P20GM103629, 0 6/01/2017-05/31/2022 , “Promoting skeletal regeneration in aged mice,” $875,000

Tulane School of Medicine, Equipment Grant, 09/01/2018, “Bruker SkyScan 1172 microCT,” $65,613

Invited Lectures

Seminar Speaker, Tulane University SOM Physiology Seminar Series, “Bone and soft tissue regeneration in a mouse model: pointing the finger at a mechanism”, August 27, 2018


Prominence

Review Service

Grant Reviewer:

Musculoskeletal Transplant Foundation

Journal Reviewer:

2017 – present, Scientific Reports

2018 – present, Stem Cells

2016 – present, Wound Journal


and Services

2011 – present, Member, the American Society for Biochemistry and Molecular Biology

2012 – present, Member, the American Society for Bone and Mineral Research (ASBMR)

2018 – present, Member, TUSOM Department of Physiology, Admissions Review Committee

2014 – present, Member, Undersea & Hyperbaric Medial Society

Mimi Sammarco, Ph.D.

Adjunct Assistant Professor Louisiana State University HSC, 2005

Research funded by NIGMS



July 1, 2018-June 30, 2019 61

Research Focus

Molecular mechanisms underlying

regulation of renin-angiotensin system


Grant Awards

NIH NIDDK 1R01DK107694 (Role: PI), “Histone Deacetylase 9 is an Epigenetic Suppressor of Intrarenal Angiotensinogen, Serving as a Key Mechanism in Angiotensinogen Augmentation in Hypertension” (2015-2020)

NIH NIDDK DK118231 (PI: Saifudeen; Role: Co-Investigator) (2018-2021)

Janssen Scientific Affairs, LLC: 28431754DIA4010 (PI: Navar; Role Co-investigator) “Role of Kidney production of AGT in the reduction of BP by SGLT2 Inhibition under diabetic and non-diabetic conditions” (12/18/15-09/30/18)

NIH - NIGMS: 1P30GM103337 (PI: Navar; Role: Director of the Molecular Core) Translational Research in Hypertension and Renal Biology-Phase III (08/01/12 – 07/31/19)

Tulane SOM Pilot Program (Role: PI) (2019-2020)


Prominence

Review Service

Journal Reviewer: Am J Med Sci, 2018 BBA, 2019 BTPR, 2019 CHM, 2018 Diabetes Care, 2018 FASEB J, 2019 Gene, 2018 Hypertension Res, 2019 Int J Mol Sci, 2018, 2019

JASN, 2019

JCDD, 2019

J Horm Dis Endocrin Res, 2018

Nephrology, 2019 Nephrol Dial Transplant, 2019 Science Reports, 2019


and Services

Departmental Level :

Director, Molecular Core, Tulane

Hypertension and Renal Center of

Excel lence/Department of Physiology

National Level:

Inst itut ional Ambassador, The American

Society of Cell Biology, 2016 -present

Ryosuke Sato, PhD

Assistant Professor Gifu University, Gifu, Japan, 2005

Research funded by NHLBI, CoBRE Pilot Project



July 1, 2018-June 30, 2019 62

Research Focus

Diabetes mell itus and chronic kidney

disease in the progre ssion of

cardiovascular disease


Tulane University SOM Owl Club Award, T1 Ranked Top 3 Phase 1 Lecturers, 2019

Tulane University SOM Owl Club Award, T1 Professor of the Year – Finalist, 2019

Grant Awards

Ochsner Clinical Research & Innovation Support Program (CRISP) grant award (Role PI) 10/01/2017 – 09/30/2018, “Mapping Serum Biomarkers of carotid plaque rupture to intra-plaque changes: Novel predictors of stroke”

NIH-NHLBI: R01HL127092-01A1(Role: PI) 04/01/2016 - 03/31/2020 , “Role of VSMC -Derived Exosomes in the Cardiovascular Complications of Diabetes ”

Janssen Scientif ic Affairs, LLC:28431754DIA4010 (PI:Navar ; Role: Co-investigator) 12/18/2015 - 05/30/2019 , “Role of Kidney Production of Angiotensinogen in the Reduction of Blood Pressure by SGLT2 Inhibit ion under Diabetic and Non -diabetic Conditions”

Invited Lectures

Participant, COBRE EAC Meeting, Department of Pharmacology, LSU Health Sciences Center,

“From a Well-known Pathway to Exosomes and ncRNA in Atherosclerosis”, May, 2019


Prominence

Editorial Boards

Scientific Reports Review Service

Grant Reviewer: National Institutes of Health, Special

Emphasis Panel Vascular (ZRG1 DKUS-H)

Journal Reviewer: Atherosclerosis Cellular Physiology and Biochemistry International Journal of General Medicine Molecular and Cellular Endocrinology


and Services

Chair , Physiology Seminar Committee,

Tulane University

Faculty Mentor, Tulane Learning

Communities

Interviewer, Graduate Program in

Biomedical Sciences

Vice Chair , General Medical Faculty

Member, IACUC Advisory Committee

Member, Medical Educational

Committee, Department of Physiology

Member, LCME Self -Study Sub-

Committee on Standards 8 & 9

T. Cooper Woods, Ph.D.

Associate Professor University of Alabama at Birmingham, 2008

Research Funded by NIH NBLBI, Ochsner CRISP, Pharmeceutical



July 1, 2018-June 30, 2019 63

Research Focus

Cancer and diabetes research which span

from basic research to therapeutics

development


Grant Awards

1R01DK107412. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (Role PI) Pax4-induced alpha-to-beta cell conversion 07/01/2016–06/30/2019; $1,015,875.

Tulane School of Medicine Bridge Funding (Role PI) $50,000 including department match 01/01/19-12/31/19


Prominence

Editorial Boards

Scientific Reports, 2013 – present

Review Service

Grant Reviewer:

Integrated Islet Distribution Program

(IIDP) Islet Award Initiative, 2018

Juvenile Diabetes Research Foundation (JDRF), 2018

NIH/NIDDK study section ZRG1 EMNR-G

(02) M, 2018

NIH/NIDDK study section CADO, 2019

Journal Reviewer:

Diabetes, Obesity and Metabolism

eBook Frontiers in Clinical Drug

Research-Diabetes and Obesity

Experimental Cell Research

Genes

Journal of International Medical Research

Molecular Therapy

PLoS One

Scientific Reports

Hongju Wu, PhD

Adjunct Associate Professor University of Alabama at Birmingham, 2001

Research funded by NIH NIDDK



July 1, 2018-June 30, 2019 64

Research Focus

Neurophysiology and central control of

whole body metabolism


Grant Awards

NIDDK R01 DK 099598 (role: PI),

04/01/2014-03/31/2020 “TRPV1-dependent

autonomic control in diabetes”

NIH NIA 099598 S1 (role: PI), 04/01/2018-

03/31/2020 “TRPV1-dependent autonomic

control in diabetes”

NIH SPARC OT2OD023864 (role:

collaborator), 08/01/2017-07/31/2018 –

“Genetically-based neuro-modulation of

adipose tissue functions”

NIH-NHLBI 2R01 HL093178 (role:

collaborator), 10-01/2014-07/31/2018

“Mechanisms of ACE2 regulation in

neurogenic hypertension”

Research Awards

Adrien Molinas, postdoctoral fellow,

received the Research in Neuroscience award

for his poster during the Tulane Health

Sciences Research Days, entitled, “Insulin-

dependent decrease of excitatory neuro-

transmission in preautonomic PVN neurons is

reduced in diet-induced obese mice”.

Adrien also received the Mead Johnson

Award from APS Endocrinology and

Metabolism section at the Experimental

Biology meeting.

Andrea Zsombok, Ph.D.

Associate Professor University of Pecs, Hungary, 2002

Research funded by NIH NIDDK & NIA

LAB MEMBERS (From left to right):

Adrien Molinas, Andrea Zsombok, Lucie Desmoulins, Sierra Butcher, and Hong Gao

Adrien Molinas during the Tulane Health Science Research Days



July 1, 2018-June 30, 2019 65


Prominence

Editorial Boards

AJP Regulatory, Integrative and Comparative Physiology (2015-present)

Journal of Diabetes and Its Complications (2016-present)

Review Service

Abstract Reviewer: APS: Endocrinology and Metabolism Section,

EB meeting 2019 Grant Reviewer: NIH NNRS Study Section (regular member

2016-2022) Journal Reviewer: AJP Regulatory, Integrative and Comparative

Physiology


and Services

Departmental level:

2011-Pres Chair, Library and Educational Aids/Website Committee

2011-Pres Member, Seminar Committee

University level:

2016-Pres Executive Board member, Tulane University-Brain Institute

2017-Pres Member, Admission Committee, Neuroscience PhD Program

2018-2019 Immediate Past Chair, General Medical Faculty

2018-Pres Member, Mentoring & Steering Committee; group on Women in Medicine & Science

2018-2021 Member, University Senate Sub-Committee for Research

National level

2015-2019 Member, APS Endocrinology and Metabolism Section, Steering Committee

2015-2019 Member, APS Memberships and FAPS Committee (EM representative)

2016-2019 Member, APS Science Policy Committee

Adrien Molinas with certificate award during the EB meeting.

As a member of the APS Science Policy Committee, Dr. Zsombok attended meetings on Capitol Hill with

US Senators to advocate for biomedical research.



July 1, 2018-June 30, 2019 66

Faculty Adjuncts

Gholam Ali, M.D., Adjunct Assistant Professor

Primary Appointment: Clinical Assistant Professor, Department of Medicine; Associate Director, Vascular Medicine

Samir S. El-Dahr, M.D., Adjunct Professor

Primary Appointment: Professor and Chair, Department of Pediatrics, Section of Nephrology

Romer Gonzalez-Villalobos, M.D., Ph.D., Adjunct Assistant Professor

Primary Appointment: Assistant Professor, Biomedical Sciences and Experimental Pathology, Cedars-Sinai, CA; Senior Principal Scientist, DSRD Safety

L. Lee Hamm, M.D., F.A.C.P., Adjunct Professor

Primary Appointment: Professor, Department of Internal Medicine, Dean, School of Medicine

Lisa M. Harrison-Bernard, Ph.D., Adjunct Associate Professor

Primary Appointment: Associate Professor, Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA

Michael G. Levitzky, Ph.D., Adjunct Professor

Primary Appointment: Professor, Department of Physiology, Louisiana State University School of Medicine, New Orleans, LA

Sarah H. Lindsey, Ph.D., Adjunct Assistant Professor

Primary Appointment: Assistant Professor, Department of Pharmacology

Laura A. Schrader-Kriek, Ph.D., Adjunct Assistant Professor

Primary Appointment: Associate Professor, Department of Cell and Molecular Biology

Juan Carlos Q. Velez, M.D., Adjunct Associate Professor

Primary Appointment: Staff Physician, Department of Nephrology, Ochsner Clinic Foundation

Postdoctoral Fellows

Lucie Desmoulins, Ph.D.

University of Burgundy, Dijon France, 2016

Mentor: Dr. Andrei Derbenev

Supaporn (Tom) Kulthinee, Ph.D.

Khon Kaen University, Thailand, 2016

Mentor: Dr. L. Gabriel Navar

Adrien Molinas, Ph.D.

Université de Bourgogne, Dijon, France, 2011

Mentor: Dr. Andrea Zsombok

Kandasamy Neelamegam, Ph.D.

Annamalai University, Tamil Nadu, India, 2014

Mentor: Dr. Kailash N. Pandey

Ramachandra Samivel, Ph.D.

Annamalai University, India, 2011


Bruna Visniauskas, Ph.D.

Federal University of Sao Paulo, Brazil, 2016

Mentor: Dr. Minolfa Prieto

Hanqing Zhao, Ph.D.

Queen Mary University of London, 2015




July 1, 2018 - June 30, 2019 67

Administrative Staff

Nora Barquero

Program Coordinator

Nina R. Majid

Senior Program Coordinator

Hypertension & Renal Center of

Excellence

Amelia R. Chaisson

Senior Department

Administrator

Debbie M. Olavarrieta

Operations Manager

Rose Grace

Accountant

Weijian Shao

Director, Departmental

Resources and Facilities

Research Staff

Laboratory Research Technicians

Medical Research Specialists

George Brand Courtney Dugas

Alexander Castillo Akemi Sato

Stephanie Crabtree

Hunter Douglas

Nicholas Huisingh Research Scientist

Natasha Klingenberg Hong Gao, Ph.D.

Hongju Lee



July 1, 2018 - June 30, 2019 68

8. DEPARTMENT PUBLICATIONS

1. Allard, C., Morford, J. J., Xu, B., Salwen, B., Xu, W., Desmoulins, L., Zsombok, A., Kim, J. K., Levin, E. R., and Mauvais-Jarvis, F. (2019) Loss of Nuclear and Membrane Estrogen Receptor-alpha Differentially Impairs Insulin Secretion and Action in Male and Female Mice. Diabetes 68, 490-501

2. Bateman, M. E., Jones, R. B., Green, E. A., John, M. M., Hilson, B., Wlodarczyk, J., Kreisman, N., Jones, C., and Chakraborti, C. (2018) Large Group Basic Science Tutorials Reduce the Stigma Surrounding Academic Assistance in the Medical School Setting. Medical Science Educator 28, 515-524

3. Boese, A. C., Le, Q. E., Pham, D., Hamblin, M. H., and Lee, J. P. (2018) Neural stem cell therapy for subacute and chronic ischemic stroke. Stem Cell Res Ther 9, 154

4. Cargill, K., Hemker, S. L., Clugston, A., Murali, A., Mukherjee, E., Liu, J., Bushnell, D., Bodnar, A. J., Saifudeen, Z., Ho, J., Bates, C. M., Kostka, D., Goetzman, E. S., and Sims-Lucas, S. (2019) Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation. J Am Soc Nephrol 30

5. Das, K. K., Honnutagi, R., Mullur, L., Reddy, R. C., Das, S., Majid, D. S. A., and Biradar, M. S. (2019) Chapter 26: Heavy Metals and Low-Oxygen Microenvironment—Its Impact on Liver Metabolism and Dietary Supplementation. In Dietary Interventions in Liver Disease pp. 315-332

6. Dong, S., Bluher, M., Zhang, Y., Wu, H., and Alahari, S. K. (2019) Development of insulin resistance in Nischarin mutant female mice. Int J Obes (Lond) 43, 1046-1057

7. El-Dahr, S. S., and Saifudeen, Z. (2019) Epigenetic regulation of renal development. Semin Cell Dev Biol 91, 111-118

8. Gao, H., Korim, W. S., Yao, S. T., Heesch, C. M., and Derbenev, A. V. (2019) Glycinergic neurotransmission in the rostral ventrolateral medulla controls the time course of baroreflex-mediated sympathoinhibition. J Physiol 597, 283-301

9. Garagliano, J. M., Katsurada, A., Miyata, K., Derbenev, A. V., Zsombok, A., Navar, L. G., and Satou, R. (2019) Advanced Glycation End Products Stimulate Angiotensinogen Production in Renal Proximal Tubular Cells. Am J Med Sci 357, 57-66

10. Gentile, C. M., Borovjagin, A. V., Richter, J. R., Jani, A. H., Wu, H., Zinn, K. R., and Warram, J. M. (2019) Genetic strategy to decrease complement activation with adenoviral therapies. PLoS One 14, e0215226

11. Gogulamudi, V. R., Mani, I., Subramanian, U., and Pandey, K. N. (2019) Genetic disruption of Npr1 depletes regulatory T cells and provokes high levels of proinflammatory cytokines and fibrosis in the kidneys of female mutant mice. Am J Physiol Renal Physiol 316, F1254-F1272



July 1, 2018 - June 30, 2019 69

12. Gonsalez, S. R., Cortes, A. L., Silva, R. C. D., Lowe, J., Prieto, M. C., and Silva Lara, L. D. (2019) Acute kidney injury overview: From basic findings to new prevention and therapy strategies. Pharmacol Ther

13. Hering-Smith, K. S., and Hamm, L. L. (2018) Acidosis and citrate: provocative interactions. Ann Transl Med 6, 374

14. Hilliard, S., Song, R., Liu, H., Chen, C. H., Li, Y., Baddoo, M., Flemington, E., Wanek, A., Kolls, J., Saifudeen, Z., and El-Dahr, S. S. (2019) Defining the dynamic chromatin landscape of mouse nephron progenitors. Biol Open 8

15. Hutson, D. D., Gurrala, R., Ogola, B. O., Zimmerman, M. A., Mostany, R., Satou, R., and Lindsey, S. H. (2019) Estrogen receptor profiles across tissues from male and female Rattus norvegicus. Biol Sex Differ 10, 4

16. Kanthaswamy, S., Ng, J., Oldt, R. F., Phillippi-Falkenstein, K., and Kubisch, H. M. (2018) SNP-based genetic characterization of the Tulane National Primate Research Center's conventional and specific pathogen-free rhesus macaque (Macaca mulatta) populations. J Med Primatol 47, 29-34

17. Kemp, B. A., Howell, N. L., Keller, S. R., Gildea, J. J., Shao, W., Navar, L. G., and Carey, R. M. (2019) Defective Renal Angiotensin III and AT2 Receptor Signaling in Prehypertensive Spontaneously Hypertensive Rats. J Am Heart Assoc 8, e012016

18. Kim, D. S., Song, L., Wang, J., Wu, H., Gou, W., Cui, W., Kim, J. S., and Wang, H. (2018) Carbon Monoxide Inhibits Islet Apoptosis via Induction of Autophagy. Antioxid Redox Signal 28, 1309-1322

19. Mani, I., and Pandey, K. N. (2019) Emerging concepts of receptor endocytosis and concurrent intracellular signaling: Mechanisms of guanylyl cyclase/natriuretic peptide receptor-A activation and trafficking. Cell Signal 60, 17-30

20. Molinas, A. J. R., Desmoulins, L. D., Hamling, B. V., Butcher, S. M., Anwar, I. J., Miyata, K., Enix, C. L., Dugas, C. M., Satou, R., Derbenev, A. V., and Zsombok, A. (2019) Interaction between TRPV1-expressing neurons in the hypothalamus. J Neurophysiol 121, 140-151

21. Navar, L. G., and Richfield, O. (2018) Why until Just Now? Undiscovered Uniqueness of the Human Glomerulus! Am J Physiol Renal Physiol 315, F1345-F1346

22. Navarro, G., Allard, C., Morford, J. J., Xu, W., Liu, S., Molinas, A. J., Butcher, S. M., Fine, N. H., Blandino-Rosano, M., Sure, V. N., Yu, S., Zhang, R., Munzberg, H., Jacobson, D. A., Katakam, P. V., Hodson, D. J., Bernal-Mizrachi, E., Zsombok, A., and Mauvais-Jarvis, F. (2018) Androgen excess in pancreatic beta cells and neurons predisposes female mice to type 2 diabetes. JCI Insight 3, e98607

23. Paige, J. T., Kremer, M., Landry, J., Hatfield, S. A., Wathieu, D., Brug, A., Lightell, D. J., Spiller, K. L., and Woods, T. C. (2019) Modulation of inflammation in wounds of diabetic patients treated with porcine urinary bladder matrix. Regen Med 14, 269-277

24. Pandey, K. N. (2018) Molecular and genetic aspects of guanylyl cyclase natriuretic peptide receptor-A in regulation of blood pressure and renal function. Physiol Genomics 50, 913-928



July 1, 2018 - June 30, 2019 70

25. Periyasamy, R., Das, S., and Pandey, K. N. (2019) Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice. Peptides 114, 17-28

26. Pu, X. A., Young, A. P., and Kubisch, H. M. (2019) Production of Transgenic Mice by Pronuclear Microinjection. Methods Mol Biol 1874, 17-41

27. Sperling, J. A., Sakamuri, S., Albuck, A. L., Sure, V. N., Evans, W. R., Peterson, N. R., Rutkai, I., Mostany, R., Satou, R., and Katakam, P. V. G. (2019) Measuring Respiration in Isolated Murine Brain Mitochondria: Implications for Mechanistic Stroke Studies. Neuromolecular Med

28. Sukhanov, S., Higashi, Y., Shai, S. Y., Snarski, P., Danchuk, S., D'Ambra, V., Tabony, M., Woods, T. C., Hou, X., Li, Z., Ozoe, A., Chandrasekar, B., Takahashi, S. I., and Delafontaine, P. (2018) SM22alpha (Smooth Muscle Protein 22-alpha) Promoter-Driven IGF1R (Insulin-Like Growth Factor 1 Receptor) Deficiency Promotes Atherosclerosis. Arterioscler Thromb Vasc Biol 38, 2306-2317

29. Willeman, M. N., Chawla, M. K., Zempare, M. A., Biwer, L. A., Hoang, L. T., Uprety, A. R., Fitzhugh, M. C., De Both, M., Coleman, P. D., Trouard, T. P., Alexander, G. E., Mitchell, K. D., Barnes, C. A., Hale, T. M., and Huentelman, M. (2019) Gradual hypertension induction in middle-aged Cyp1a1-Ren2 transgenic rats produces significant impairments in spatial learning. Physiological Reports 7, e14010

30. Woods, T. C., Satou, R., Miyata, K., Katsurada, A., Dugas, C. M., Klingenberg, N. C., Fonseca, V. A., and Navar, L. G. (2019) Canagliflozin Prevents Intrarenal Angiotensinogen Augmentation and Mitigates Kidney Injury and Hypertension in Mouse Model of Type 2 Diabetes Mellitus. Am J Nephrol 49, 331-342

31. Xu, J., Molinas, A. J. R., Mukerjee, S., Morgan, D. A., Rahmouni, K., Zsombok, A., and Lazartigues, E. (2019) Activation of ADAM17 (A Disintegrin and Metalloprotease 17) on Glutamatergic Neurons Selectively Promotes Sympathoexcitation. Hypertension 73, 1266-1274

32. Yang, E. J., Mahmood, U., Kim, H., Choi, M., Choi, Y., Lee, J. P., Cho, J. Y., Hyun, J. W., Kim, Y. S., Chang, M. J., and Kim, H. S. (2018) Phloroglucinol ameliorates cognitive impairments by reducing the amyloid beta peptide burden and pro-inflammatory cytokines in the hippocampus of 5XFAD mice. Free Radic Biol Med 126, 221-234

33. Yu, S., Cheng, H., Francois, M., Qualls-Creekmore, E., Huesing, C., He, Y., Jiang, Y., Gao, H., Xu, Y., Zsombok, A., Derbenev, A. V., Nillni, E. A., Burk, D. H., Morrison, C. D., Berthoud, H. R., and Munzberg, H. (2018) Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife 7, e33505

34. Zhang, Y., Parajuli, K. R., Fava, G. E., Gupta, R., Xu, W., Nguyen, L. U., Zakaria, A. F., Fonseca, V. A., Wang, H., Mauvais-Jarvis, F., Sloop, K. W., and Wu, H. (2019) GLP-1 Receptor in Pancreatic alpha-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner. Diabetes 68, 34-44

35. Zwezdaryk, K., Sullivan, D., and Saifudeen, Z. (2018) The p53/Adipose-Tissue/Cancer Nexus. Front Endocrinol (Lausanne) 9, 457



July 1, 2018 - June 30, 2019 71

9. ABSTRACT & ORAL PRESENTATIONS

Society for the Study of Ingestive Behavior (SSIB) Meeting, Bonita Springs,

FL - July 17-22, 2018

Desmoulins LD, Hamling BV, Katsurada A, Zsombok A. Hypothalamic Trpv1-

expressing neurons and the regulation of energy homeostasis. #P67

Desmoulins LD, Zsombok A. Monosynaptic inputs to hypothalamic Trpv1-

expressing neurons. #P12

ASH /AHA Council on Hypertension, Joint Scientific Sessions, Chicago,

IL – September 6-9, 2018

Castillo A, Khan N, Shindler I, Navar LG, and Majid DSA. Inverse Circadian

Pattern in the Renal Generation of Tumor Necrosis Factor-Alpha (TNFá) and

Angiotensinogen (AGT) in Salt-Sensitive Hypertension (SSH) Induced by

Angiotensin II (AngII) in Mice. #P380 Hypertension. 2018;72:AP380

Gogulamudi VR, Mani I, Subramanian U, and Pandey KN. Effect of

Rapamycin on the Expression of T Regulatory Cells, Foxp3, and Toll-Like



July 1, 2018 - June 30, 2019 72

Receptors in the Kidneys of Npr1 Gene-Knockout Mice. #P161 Hypertension.

2018;72:A161

Howell NL, Kemp BA, Keller SR, Gildea JJ, Shao W, Navar LG, and Carey RM.

Identification of s Primary Renal AT2 Receptor Defect in Spontaneously

Hypertensive Rats (SHR). #O33.

Kulthinee S, Shao W, Franco M, Navar LG. Purinergic P2X1 and P2X7

Receptors Activation Attenuate Angiotensin AT1 Receptors Dominance in

Regulating the Preglomerular Renal Microcirculation in Angiotensin II Dependent

Hypertension. #O64

Kumar P, Bloodworth M, Nguyen C, Gogulamudi VR, and Pandey KN.

Differential Regulation of Blood Pressure and Renal Injury by HDAC Inhibitor

Mocetinostat in Npr1 Gene-targeted Male and Female Mutant Mice. #P255

Hypertension. 2018;72:A255

Satou R, Woods TC, Miyata K, Katsurada A, Dugas CM, Klingenberg NC, and

Navar LG. Real-Time Analysis of Blood Glucose Dynamics by a Glucose

Telemetry System in Canagliflozin-Treated Diabetic Mice. #P327

Subramanian U, Samivel R, Zhao H, Gogulamudi V and Pandey KN.

Transforming Growth Factor-Beta-Receptor Antagonist Blocks the Cardiac

Fibrosis and Remodeling in Guanylyl Cyclase/Natriuretic Peptide Receptor-A

Gene-Disrupted Mice. #101 Hypertension. 2018;72:A101

APS Conference: Cardiovascular, Renal and Metabolic Diseases: Sex-

Specific Implications for Physiology, Knoxville, TN. September 30 – October

3, 2018

Hutson DD, Gurrala R, Mostany R, Satou R, and Lindsey SH. Tissue-Specific

Estrogen Receptor Profiling Using Droplet Digital PCR.

American Society of Nephrology Annual Meeting, San Diego, CA – October

23-28, 2018

Shingarev RA, Latcha S, Sathick IJ, Prieto MC, Jaimes EA. Hypertension and

Proteinuria after Antiangiogenic Drugs: Role of the Renin-Angiotensin-Aldosterone

System. #FR-PO339

Song R, Baddoo MC, Liu H, Saifudeen ZR, El-Dahr SS. Dynamic Chromatin

Accessibility at Poised Developmental Enhancers of Nephron Progenitors. #FR-

PO917



July 1, 2018 - June 30, 2019 73

Society of Neuroscience Meeting, San Diego, CA – November 3-7, 2018

Derbenev A, Torres H, Burk D, Berthoud H-R, Munzberg H, Zsombok A.

Sympathetic innervation of the kidney and liver. #0017

American Society of Cell Biology Meeting (San Diego, CA) – December 8-12,

2018

Yanofsky SM, Dugas CM, Katsurada A, El-Dahr SS, Saifudeen Z and Satou R.

Regulation of renal structural formation by angiotensin II in iPSC-derived human

kidney organoids. #P2566

Eastern Association for the Surgery of Trauma Annual Scientific Assembly,

Austin Texas – January 15-19, 2019

Jackson-Weaver O, Friedman JK, Rodriguez LA, Hoof MA, Drury RH, Packer

JT, Guidry C, Hong S, Duchesne JC. High dose catecholamines are protective to

the endothelial glycocalyx in a cellular model for shock.

Southern Regional Meeting, New Orleans, LA – February 21-23, 2019

Curnow A, Gonsalez SR, Visniauskas B, Crabtree SL, Gogulamudi VR, Simon

EE, Lara Morcillo LD and Prieto MC. Nitric oxide synthase inhibition stimulates

renin synthesis independent of CGMP in collecting duct cells. J Investig Med

67:565, 2019. #545C (SSCI Young Investigators Award-Third Place)

Hughes JB, LI T, Brumfield I, El-Dahr SS and Saifudeen Z. The

mevalonate/cholesterol biosynthesis pathway in nephron progenitor cell renewal.

Platform presentation. J Investig Med 67:638, 2019. #719 (SSPR Trainee Travel

Award Winner)



July 1, 2018 - June 30, 2019 74

Kulthinee S, Shao W, Brand G, Franco M, Navar L. Dominance of purinergic

P2X1 and P2X7 receptors mitigates angiotensin AT1 receptors influence on renal

microvascular resistance in angiotensin II dependent hypertension. J Investig Med

67:639, 2019. #721

Penrose HM and Savkovic SD. Transcriptome profiling of inflammatory bowel

disease patients reveals shared and unique alterations in immune cells, molecular

pathways, and transcripts. J Investig Med 67:587, 2019. #589 (SAFMR/SSCI

Student Research Travel Award Winner)

Richfield O, Cortez R and Navar LG. Glomerular capillary wall shear stress in

the diabetic rat: A modeling study. J Investig Med 67:616, 2019. #662

(SAFMR/SSCI Student Research Travel Award Winner)

Samivel R, Chen H, Subramanian U, Zhao H and Pandey KN. Blockade of

cardiac hypertrophy and fibrosis by TGF-Beta 1 receptor antagonist in NPR1 gene-

knockout mice. J Investig Med 67:356, 2019. (SAFMR/SSCI Student Research

Travel Award Winner)

Visniauskas B, Crabtree SL, Castro JV, Acosta M, Curnow A and Prieto MC.

Activation of prorenin receptor (PRR) stimulates production of TNFA and IL-6 in

murine macrophages. J Investig Med 67:618, 2019. #667 (SSCI Nephrology

Young Investigator Scholar Award Winner)

Yanofsky SM, Dugas CM, Katsurada A, El-Dahr SS, Saifudeen Z and Satou R.

Angiotensin II biphasically regulates cell differentiation in induced pluripotent stem

cell-derived human kidney organoids. J Investig Med 67:617, 2019. #665

(SAFMR/SSCI Student Research Travel Award Winner)

Western Trauma Association Annual Meeting, Snowmass Colorado – March

3-8, 2019

Jackson-Weaver O, Friedman JK, Guidry C, Smith A, Schreiber M, Duchesne

J. Hypoxia/reoxygenation produces greater endothelial glycocalyx damage than

ischemia alone in a cellular model for shock. Selected for the EE Moore Resident

Prize for Basic Science Research Competition.

International Federation of Musculoskeletal Research Societies 3rd Herbert

Fleisch Workshop, Bruges, Belgium – March 17-19, 2019

Busse E, Simkin J, Stewart K, Sammarco M. The influence of cellular

metabolism on digit regeneration.



July 1, 2018 - June 30, 2019 75

Tulane Health Sciences Research Days, New Orleans, LA – March 18-19, 2019

Curnow A, Gonzales SR, Visniauskas B, Crabtree SL, Gogulamudi VR, Simon

EE. Nitric Oxide Synthase Inhibition Stimulates Renin Synthesis Independent of

cGMP in Collecting Duct Cells (2016 Summer Student/Prieto Lab) #A41

Desmoulins LD, Molinas AJR, Litsky NM, Sharon T, Riklan JE, Zsombok A.

TRPV1-expressing neurons of the caudal Hypothalamus project to

thermoregulatory POA neurons (Postdoc/Derbenev). #B11

Drouin A, Loupe W, Lorang C, Fusco D. A relatively Immunocompetent Mouse

Model for Improved Understanding of Dengue Virus Pathology (MS Student,

William Loupe-additional author) #B34

Hong J, Visniauskas B, Crabtree S, Arita DY, Rosales CB, Feroz M, Jaimes E,

Ducoin C, Levy S, Thethi TK, Fonseca, V, Mauvais-Jarvis, F, and Prieto MC.

Soluble Prorenin Receptor (sPRR) is Increased in Plasma of Obese Diabetic

Women but not in Men (2018 Summer Student/Prieto Lab) #A11

Kremer M, Paige J, Woods TC. Modulation of Inflammation in Wounds of Diabetic

Patients Treated With Porcine Urinary Bladder Matrix (2017 Summer

Student/Woods Lab). #A21

Lu Y. A Novel Way to Design Pharmaceutical Drugs (Graduate Student/Li). #A31

Molinas, AJR, Desmoulins LD, Gao H, Zsombok A. Insulin-dependent decrease

of excitatory neurotransmission in preautonomic PVN neurons is reduced in diet-

induced obese mice (Postdoc/Zsombok). #B42

Sun Y(C), Lu Y, Li M. Computer based drug screening for identification of novel

T-type calcium channel specific blockers (MS Student). #A42



July 1, 2018 - June 30, 2019 76

Visniauskas B, Mourain J, Crabtree S, Jorgensen JA, Chagas JR, Prieto MC.

Bradykinin levels and kallikrein 1 activity are reduced in mice with prorenin receptor

(PRR) deficiency in the collecting duct (Postdoc/Prieto). #A39

Werner CD, Butcher SM, Kaminsky EB, Hamling BV, Desmoulins LD,

Zsombok A. Identification of subsets of neurons projecting from the hypothalamus

to both pancreas and interscapular brown adipose tissue (2018 Summer

Student/Zsombok Lab) #B43

Biomedical Engineering Society (BMES)/FDA Frontiers in Medical Devices

Conference, Washington, DC – March 19-21, 2019

Richfield O, Cortez R, Navar LG. Glomerular Capillary Hypertrophy in the

Diabetic Rat Normalizes Wall Shear Stress: A Modeling Study

Endocrine Society Annual Meeting, New Orleans, LA – March 23-26, 2019

Kumar P, Pandya K, Pandey K. Modulation of Histone 3 Acetylation and

Methylation Enhances the Expression and Function of Npr1 in Haplotype Mice.

#SAT-046. J Endocrin Soc, Vol 3, Issue Suppl 1, April-May 2019.

https://doi.org/10.1210/js.2019

Experimental Biology Meeting, Orlando, FL – April 6-9, 2019

Kumar P. Inhibition of DNA Methylation Regulates Guanylyl Cyclase/Natriuretic

Peptide Receptor-A Gene Expression. Faseb J. Volume 33, Issue 1, supplement,

Apr 2019. #621.8

Kumar P, Pandya K, and Pandey KN. Regulation of Natriuretic Peptide Receptor-

A Expression in Gene-targeted Mice via Modulation of Histone 3 Acetylation and

Methylation Levels. Faseb J. Volume 33, Issue 1, supplement, Apr 2019. #595.3

Majid DSA, Ekpo PE, Talwar S, Abdel-Mageed AB, and Castillo A. The protein

expression of TNF-α receptor type 1 (TNFR1) is reduced by nitric oxide (NO)

https://doi.org/10.1210/js.2019



July 1, 2018 - June 30, 2019 77

synthase inhibition in cultured renal proximal tubular (HK-2) cells. Faseb J. Volume

33, Issue 1, supplement, Apr 2019. #569.15

Molinas JA, Desmoulins LD, Gao H, and Zsombok A. Insulin-dependent

Decrease of Excitatory Neurotransmission in Preautonomic PVN Neurons Is

Reduced in Diet-induced Obese Mice. Faseb J. Volume 33, Issue 1, supplement,

Apr 2019. #555.1

Mukerjee S, Gao G, Zsombok A, and Lazartigues E. ACE2 expression on

inhibitory neurons controls neuronal excitability of the PVN. Faseb J. Volume 33,

Issue 1, supplement, Apr 2019. #850.4

Nakhoul NL, Hering-Smith K, Hamm LL, and Abdulnour-Nakhoul S. Renal

Adaptive Changes in Response to Chronic Metabolic or Respiratory Acidosis:

Regulation of Expression of Acid-base Transporters and Enzymes. #544.19

Periyasamy R, Das S, and Pandey KN. Genetic disruption of guanylyl

cyclase/natriuretic peptide receptor-A upregulates renal (pro)renin receptor

expression in Npr1 null mutant mice. Faseb J. Volume 33, Issue 1, supplement,

Apr 2019. #576.3

Richfield O, Cortez R, and Navar LG. Glomerular capillary wall shear stress in

the diabetic rat: A modeling study. Faseb J. Volume 33, Issue 1, supplement, Apr

2019. #748.13

Samivel R, Subramanian U, Oakes JM, Chen H, Zhao H, Gardner JD, and

Pandey KN. Blockade of Cardiac Hypertrophy and Fibrosis by TGF-Beta 1

Receptor Antagonist in Npr1 Gene-Knockout Mice. Faseb J. Volume 33, Issue 1,

supplement, Apr 2019. #531.10

Visniauskas B, Wong CTU, Crabtree S, Hong J, Reverte V, Rosales CB,

Mostany R, Prieto MC. High plasma soluble prorenin receptor (sPRR) levels

correlate with systolic blood pressure in aged male but not in female mice. Faseb

J. Volume 33, Issue 1, supplement, Apr 2019. #758.7

Xu J, Molinas A, Zsombok A, and Lazartigues E. ADAM17 on glutamatergic

neurons contributes to peripheral immune activation through increasing

sympathetic activity. Faseb J. Volume 33, Issue 1, supplement, Apr 2019. #740.6



July 1, 2018 - June 30, 2019 78

APS/ASN Renal Summer Conference: Control of Renal Function in Health and

Disease, Charlottesville, VA – June 23-27, 2019

Kulthinee S, Shao W, Brand G, Franco M, Navar LG. Purinergic P2X receptor

and angiotensin AT1 receptor interactions in the regulation of preglomerular renal

microcirculation in angiotensin II dependent hypertension. #12.4

Richfield O, Cortez R, Navar LG. Shear stress is normalized while hoop stress

remains elevated in the diabetic rat glomerulus: A modeling study. #4.4



July 1, 2018 - June 30, 2019 79

10. FINANCIAL INFORMATION

Sponsored Projects Dates Direct

Costs

Indirect

Costs Total

Andrei Derbenev:

NIH – NHLBI: RO1HL122829

(PI)

Sympathetic control and

hypertension via brainstem

cannabinoid signaling

06/01/18-

05/31/19

$271,573 $103,553 $375,126

Jean-Pyo Lee:

NIH – NINDS: RO1 NS110370

Combination treatment of

ischemic stroke with perlecan DV

and neural stem cells

12/15/18-

11/30/19

$348,902 $132,638 $481,540

L. Gabriel Navar:

NRSA NIH-NIDDK:

1F31DK121445 (Owen

Richfield/Navar)

Develop of a computational

biomechanics model of the

glomerulus to assess the risk of

mechanical stress-induced

glomerular injury

05/10/19-

05/16/20

$29,016 $0 $29,016

NIH - NIGMS: 1P30GM103337

Translational Research in

Hypertension and Renal Biology

08/01/18-

07/31/19

$68,999 $30,795 $99,794



July 1, 2018 - June 30, 2019 80

NIH - NHLBI–University of

Virginia: Subaward No

GB10298-01A1

MD-INMD-EN Renal AT2

Receptors in Hypertension

04/01/18-

03/31/19

$30,000 $15,150 $45,150

Janssen Scientific Affairs,

LLC: 28431754DIA4010 (PI)

Role of Kidney production of AGT

in the reduction of BP by SGLT2

Inhibition under diabetic and non-

diabetic conditions

07/01/17-

05/31/19

$1,786 $897 $2,683

Kailash N. Pandey:

NIH - NHLBI: 5R01HL062147

Study of ANP Receptor: Gene

targeting and expression

04/01/18-

03/31/19

$250,000 $126,250 $376,250

Tulane-Carol Lavin Bernick

Faculty Grant Award

ANP Receptor-Molecular

Approach of Signaling

Mechanisms

07/01/18-

06/30/19

$10,000 $0 $10,000

Minolfa Prieto:

NIH - NIDDK: 1R01DK104375

Pleiotropic effects of prorenin

receptor in the collecting duct and

intrarenal RAS activation

07/01/18-

06/30/19

$225,000 $113,625 $338,625

NIH – CCTS-UAB Partner

Network Multidisciplinary Pilot

04/01/18-

03/31/19

$18,616 $0 $18,616



July 1, 2018 - June 30, 2019 81

Impact of plasma soluble

prorenin receptor in obese & type

2 diabetic patients

APS

Sex differences in the epigenetics

regulation of AGT in proximal

tubule cells using dCRISPR-

Casp9 technology

08/01/18-

07/31/19

$20,000 $0 $20,000

Ryosuke Sato:

NIH NIDDK: 1RO1DK107694

(PI)

Histone Deacetylase 9 is an

Epigenetic Suppressor of

Intrarenal Angiotensinogen,

Serving as a Key Mechanism in

Angiotensinogen Augmentation in

Hypertension

12/01/17-

11/30/18

$162,000 $81,810 $243,810


LLC: 28431754DIA4010 (Co-PI)




diabetic conditions

07/01/17-

05/31/19

$1,786 $897 $2,683*

T. Cooper Woods:

NIH NHLBI: R01HL127092 (PI)

Role of VSMC-Derived

Exosomes in the Cardiovascular

Complications of Diabetes

03/01/18-

02/28/19

$263,750 $113,625 $377,375


LLC: 28431754DIA4010 (Co-PI)

07/01/17-

05/31/19

$1,786 $897 $2,683*



July 1, 2018 - June 30, 2019 82




diabetic conditions

CRISP (Clinical Research &

Innovation Support Program) –

Ochsner Clinic Foundation

Mapping serum biomarkers of

carotid plaque rupture to intra-

plaque changes: Novel predictors

of stroke

10/01/17-

09/30/18

$16,712 $0 $16,712

Andrea Zsombok:

NIH NIDDK: R01DK099598 (PI)

TRPV1-dependent autonomic

control in diabetes

04/01/18-

03/30/19

$222,500 $112,363 $334,863

NIH NIDDK: R01DK099598 Supplement (PI)

TRPV1-dependent autonomic

control in diabetes

07/01/18-

06/30/19

$229,280 $105,583 $334,863

TOTALS $2,168,134 $936,289 $3,104,423

*Amount is already listed for another faculty member, therefore not added in to compute overall totals.



July 1, 2018 - June 30, 2019 83

$0

$500,000

$1,000,000

$1,500,000

$2,000,000

$2,500,000

$3,000,000

$3,500,000

Direct CostsIndirectCosts Total

$2,168,134

$936,289

$3,104,423

Sponsored Projects 2018-2019



July 1, 2018 - June 30, 2019 84

$0

$1

$2

$3

$4

$5

$6

(Mil

lio

ns)

Department of Physiology Extramural Research Funding

2000-Present

Direct Costs Indirect Costs



July 1, 2018 - June 30, 2019 85

$0

$50

$100

$150

$200

$250

$300

$350

$400

$450

(Th

ou

san

ds)

Department of PhysiologyResearch Funds Per Faculty

2000-Present

Direct Costs Indirect Costs



July 1, 2018 - June 30, 2019 86

11. OUTREACH PROGRAM

PARTICIPATION

American Heart Association Heart Walk

The Heart Walk is the American Heart

Association's premiere event for

raising funds to save lives from heart

disease and stroke. This year’s walk

was held at LaSalle Park in Metairie

on November 17, 2018.



July 1, 2018 - June 30, 2019 87

World Kidney Day

World Kidney Day (WKD) is a global awareness campaign aimed at raising awareness

of the importance of our kidneys. This year, WKD set out to raise awareness of the

high and increasing burden of kidney diseases worldwide and the need for strategies

for kidney diseases prevention and management. Kidney Health for Everyone

Everywhere calls for universal health coverage (UHC) for prevention and early

treatment of kidney disease. On March 14, 2019, members of the Department of

Physiology and the Tulane Hypertension & Renal Center of Excellence participated in

a health screening event.



July 1, 2018 - June 30, 2019 88

12. DEPARTMENTAL & OTHER EVENTS

L. Gabby Navar Symposium Dinner



July 1, 2018 - June 30, 2019 89



July 1, 2018 - June 30, 2019 90

Halloween in the Department of Physiology



July 1, 2018 - June 30, 2019 91

Annual Department Appreciation Meeting



July 1, 2018 - June 30, 2019 92



July 1, 2018 - June 30, 2019 93

Department Meeting – Certificates Awarded

Alex Castillo – 15 Years of Service

Dr. Kenneth Mitchell – 30 Years of Service

Dr. Weijian Shao – 20 Years of Service

Dr. T. Cooper Woods – 5 Years of Service

Rose Grace – Outstanding Staff Award

Dr. L. Gabriel Navar – 30 Years of Service

Tulane University Prepared by:

Department of Physiology Debbie Olavarrieta

2017-2018 Annual Report Operations Manager

l gabby navar symposium - medicine.tulane.edu report...for 2019, medical students annie bell and...

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