komen announces advisory roles for 12 leaders in breast …...individuals will join an esteemed...
TRANSCRIPT
Mission Advisors Health Equity Advocacy Metastatic Breast Cancer View this email in your browser View the archive library here
Komen Announces Advisory Roles for12 Leaders in Breast Cancer
In April we announced new advisory roles for 12 leaders in breast cancer Theseindividuals will join an esteemed group of breast cancer researchers clinicians andadvocates who help guide the organizationrsquos research programs which total $956million since our inception ndash the largest investment in breast cancer research outsideof the US government
Ten new individuals will join the Komen Scholars in addition to the 49 currentlyserving
Wayne Dornan PhD Advocates in Science Steering
Committee Smyrna TN(survivor research advocacy)
Reshma Jagsi MD DPhil University of Michigan Ann Arbor MI
(radiation oncology health outcomeshealth care systems delivery)
Marian Johnson-Thompson PhD Advocates in Science Steering
Committee Durham NC (co-survivor research advocacy)
Ingrid Mayer MD MSci Vanderbilt University Medical Center
Nashville TN (oncology clinical trials novel
therapeutics)
Donald McDonnell PhD Duke University School of Medicine
Durham NC (cancer biology endocrinology novel
therapeutics)
Julie Palmer ScD MPH Boston University Boston MA
(co-survivor health disparitiesepidemiology breast cancer risk risk
reduction)
Amelie Ramirez Dr PH University of Texas Health Science
Center San Antonio TX (health disparities health care systems
delivery public health)
Rebecca Seago-Coyle MA Advocates in Science Steering
Committee Rochester WA (survivor research advocacy)
Sohrab Shah PhD Memorial Sloan Kettering Cancer Center
New York NY (cancer genomics computational
biology bioinformatics)
Meryl Weinreb MA Advocates in Science Steering
Committee Landenberg PA (survivor research advocacy)
Two long-standing Komen Scholars will continue their service with Komen as newmembers of the Scientific Advisory Board (SAB) joining 6 continuing members
Lisa Carey MD of the University ofNorth Carolina LinebergerComprehensive Cancer Center ChapelHill NC has been a Komen Scholarsince 2010 and brings expertise inclinical research molecular sub-typesof breast cancer and treatmentresponse to the SAB
Sandy Finestone PsyD a KomenAdvocate in Science (AIS) from CostaMesa CA is a 30+ year breast cancersurvivor and research advocate andhas been a volunteer with Susan GKomen for over 25 years She bringsknowledge in patient support andresearch advocacy to the SAB
We congratulate and thank all our Mission Advisors as we continue to move towardsour Bold Goal of reducing breast cancer deaths by 50 in the US by 2026
Komen is Addressing Health Equity
Breast cancer deaths rates are about40 percent higher for black women inthe US compared to white women Inan April US News amp WorldReport article Komen President andCEO Paula Schneider outlines theinjustice of barriers to breast cancercare and Komenrsquos drive for healthequity through our African-AmericanHealth Equity Initiative and our BoldGoal
Komen is aiming to improve our understanding of health equity by funding researchthat will investigate some of the causes of health disparities A recent Journal ofClinical Oncology publication co-authored by Stephanie Wheeler PhD Komen-funded grantee Katherine Reeder-Hayes MD and Komen SAB member LisaCarey MD shows that increased financial strain on African-American women maycontribute to higher stress lower treatment compliance and worse breast canceroutcomes Komen is working to address financial barriers to care by
1 Providing financial aid to breast cancer patients through the Komen NationalTreatment Assistant Program Learn more by calling our National Breast CareHelpline at 1-877 GO KOMEN open daily from 900 am to 1000 pm ET orby emailing the helpline at helplinekomenorg
2 Advocating for policies that will improve health insurance coverage increasefederal research funding support early detection and increase access toclinical trials
3 Funding patient navigation programs that guide women through the healthcare continuum which includes locating financial resources and addressingbarriers such as cost of care
Komen also offers information about resources to help with financial barriers tobreast cancer care
Komen Advocacy
In a March Komen blog Komen AIS member Mona Jaffe Rowe discussed heradvocacy efforts in Maryland She spearheaded efforts to urge state law makers topass legislation requiring insurance companies to cover medically necessarydiagnostic imaging no less favorably than screening mammography Also in Marchrepresentatives from Affiliates Advocates in Science Komen Scholars and Komenstaff met in DC at Komenrsquos annual Advocacy Summit to encourage policymakers tomake breast cancer a priority Sign up here to stay up-to-date on Komens publicpolicy and advocacy efforts
Representatives from Affiliates Advocates in Science Komen Scholars Komen staff community
members and breast cancer survivors at Komenrsquos annual Advocacy Summit on March 21-23 2018
(Left to right) Komen Scholar Hari Nakshatri PhD Komen Central Indiana Affiliate Mission
Director Stephanie Laskey Komen Evansville Tri-State Executive Director Sheila Seiler Indiana
Senator Todd Young and Komen Research Review Manager Andrew Smith PhD meet on Capitol
Hill at the Komen Advocacy Summit in March
Alongside the Advocacy Summit the Komen Health Equity team hosted anAdvocacy training pilot called lsquoSpeak Truth to Powerrsquo where Komen communitystakeholders Affiliates and staff gathered to collectively discuss how far wersquove comeand to collaboratively plan where we are going The program included severalspeakers in the advocacy field collective discussions and Hill Day visits The HealthEquity team would like to thank the generous funders of this event the Fund IIFoundation and Pfizer for making the pilot training such a success
Gaining New Ground in Breast CancerResearch
In a recent Komen blogChief ScientificAdvisors George SledgeMD and JenniferPietenpol PhD talkabout the state of breastcancer research what wemay have missed in 2017whatrsquos exciting now andhow Komen is poised totackle the most excitingand important questions inbreast cancer
Komenrsquos Global and Local Outreach toAddress Metastatic Breast Cancer (MBC)
KomenPfizer Partnership is Bringing Effective Solutions for MBC
Pfizer the European School of Oncology (ESO) the Advanced Breast Cancer ThirdInternational Consensus Conference (ABC3) and leaders in the MBC community(including Komen) collaborated to pull together a report on the global analysis ofMBC spanning a decade (2005 ndash 2015) The report recently published in TheBreast calls attention to the gaps in care resources and support for MBC patients indifferent parts of the world
Unfortunately in lower
income countries about50-80 percent of patientsare diagnosed with latestage breast cancer(stage III or IV) comparedto 10-15 percent ofdiagnoses in high-incomecountries (like the US) Therefore Komen andPfizer have partnered totake on the global burdenof MBC You can readmore about progress andfuture goals of this effortin a recent Komen blog
KomenPfizer Partnership for Local Education about MBC
As an extension of this partnership Komen and Pfizer have teamed up to supporteducational programs for those living with MBC and their caregivers in the USSpecifically Pfizer is donating $500000 in support of MBC programming at KomenAffiliates Through May 31 2018 Affiliates are encouraged to submit applications forfunding which can include evidence-based patient-focused conferences events andother activities designed to educate the MBC community at the local level Learnmore here
Komenrsquos Work in Tanzania
Komen and the Tanzania Ministry of Health with input from global health and civilsociety experts have developed National Guidelines for Early Diagnosis of BreastCancer and Referral for Treatment in Tanzania The new guidelines are vital toaddressing breast cancer in Tanzania ndash a country where about 80 percent of womenare diagnosed with late-stage disease when treatment options are limited Learnmore in a new Komen Press Release
Upcoming Research FundingOpportunities
Komen will continue its research investment in early career breast cancerresearchers The new Request for Applications (RFAs) will be posted in the nextmonth or two on our Funding Opportunities page Stay tuned
Komen-funded young investigator Toni Celia-Terrassa PhD (left) and Komen Scholar YibinKang PhD (right) in the lab at Princeton University
Komen Kudos
Komen-funded grantee Lisa Coussens PhD was honored with the 12thAACR-Princess Takamatsu Memorial Lectureship for her impactful work on theimmune response in cancerFormer Komen Scholars Lori Pierce MD and Julie Gralow MD willbe honored as leaders in oncology at the 2018 American Association ofClinical Oncology (ASCO) meeting in June Dr Pierce will be given theHologic Inc Endowed Women Who Conquer Cancer Mentorship Award amp DrGralow will be given the Humanitarian AwardKomen-funded grantee Nikhil Wagle MD and his teamrsquos work presented atthe 2018 American Association for Cancer Research (AACR) Annual Meetingwas featured in The ASCO Post This works shows we are movingtoward improving clinical care for individuals with MBC Komen partner Metro Elevator raised over $174000 for breast cancerresearch Thank you Metro ElevatorDaniel Stover MD a Komen grant recipient funded by AmericanAirlines was named The Ohio State University May Physician of the Month
Research Snapshots
If cancer cells are found in the lymphnode does that mean they can spreadto distant organs Experts still debatethis Using imaging techniques a teamof scientists including formerKomen grantee Giorgio SeanoPhDco-authored a publication
in Science showing that cancer cellsthat have spread to a nearby lymphnode can invade the blood stream andspread (or metastasize) to otherorgans
Although triple negative breast cancer(TNBC) can be treated we stilllack effective targeted treatments forthis aggressive subtype In a Komen-funded study published in NatureMedicine Thomas (Trey) WestbrookPhD and colleagues discovered newTNBC therapeutic targets andstrategies which will soon be tested inthe clinic Learn more about theseimportant results here
According to a recent study publishedin Clinical Cancer Research higherlymphocyte counts predict lowermortality in early-stage TNBCsuggesting that higher immunefunction improves treatmenteffectiveness in this patient populationKomen-funded researchers thatcontributed to these findings includefirst author Anosheh AfghahiMD (pictured left) Christina CurtisPhD Chief Scientific Advisor GeorgeSledge MD Komen Scholar MelindaTelli MD and former KomenScholar Sunil Badve MD Morecoverage of this study can befound here
New strategies to block the return of breast cancer are desperately needed toimprove patient outcomes In a Komen-funded study recently publishedin Nature Subhamoy Dasgupta PhD former Komen Scholar Bert OrsquoMalleyMD and their team identified two proteins involved in metabolism that could be
targeted to stop tumor recurrence andor prevent breast cancer metastasis You canread more here
In a new Journal of ClinicalInvestigation publication Komen-funded grantee Weibo Lou PhD andteam show that a protein calledZMYND8 helps estrogen receptor (ER)-positive breast cancers survive andgrow in a low-oxygen environment andmay be a target to treat MBC You canread more about this exciting data
In a recent NatureCommunications publication DanielMcGrail PhD and colleagues showthat cytokine release (mediated by theDNA damage response protein ATM) isa primary driver of T-cell infiltration intoa tumor ndash a characteristic that candictate response to immunotherapies
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email us
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
Marian Johnson-Thompson PhD Advocates in Science Steering
Committee Durham NC (co-survivor research advocacy)
Ingrid Mayer MD MSci Vanderbilt University Medical Center
Nashville TN (oncology clinical trials novel
therapeutics)
Donald McDonnell PhD Duke University School of Medicine
Durham NC (cancer biology endocrinology novel
therapeutics)
Julie Palmer ScD MPH Boston University Boston MA
(co-survivor health disparitiesepidemiology breast cancer risk risk
reduction)
Amelie Ramirez Dr PH University of Texas Health Science
Center San Antonio TX (health disparities health care systems
delivery public health)
Rebecca Seago-Coyle MA Advocates in Science Steering
Committee Rochester WA (survivor research advocacy)
Sohrab Shah PhD Memorial Sloan Kettering Cancer Center
New York NY (cancer genomics computational
biology bioinformatics)
Meryl Weinreb MA Advocates in Science Steering
Committee Landenberg PA (survivor research advocacy)
Two long-standing Komen Scholars will continue their service with Komen as newmembers of the Scientific Advisory Board (SAB) joining 6 continuing members
Lisa Carey MD of the University ofNorth Carolina LinebergerComprehensive Cancer Center ChapelHill NC has been a Komen Scholarsince 2010 and brings expertise inclinical research molecular sub-typesof breast cancer and treatmentresponse to the SAB
Sandy Finestone PsyD a KomenAdvocate in Science (AIS) from CostaMesa CA is a 30+ year breast cancersurvivor and research advocate andhas been a volunteer with Susan GKomen for over 25 years She bringsknowledge in patient support andresearch advocacy to the SAB
We congratulate and thank all our Mission Advisors as we continue to move towardsour Bold Goal of reducing breast cancer deaths by 50 in the US by 2026
Komen is Addressing Health Equity
Breast cancer deaths rates are about40 percent higher for black women inthe US compared to white women Inan April US News amp WorldReport article Komen President andCEO Paula Schneider outlines theinjustice of barriers to breast cancercare and Komenrsquos drive for healthequity through our African-AmericanHealth Equity Initiative and our BoldGoal
Komen is aiming to improve our understanding of health equity by funding researchthat will investigate some of the causes of health disparities A recent Journal ofClinical Oncology publication co-authored by Stephanie Wheeler PhD Komen-funded grantee Katherine Reeder-Hayes MD and Komen SAB member LisaCarey MD shows that increased financial strain on African-American women maycontribute to higher stress lower treatment compliance and worse breast canceroutcomes Komen is working to address financial barriers to care by
1 Providing financial aid to breast cancer patients through the Komen NationalTreatment Assistant Program Learn more by calling our National Breast CareHelpline at 1-877 GO KOMEN open daily from 900 am to 1000 pm ET orby emailing the helpline at helplinekomenorg
2 Advocating for policies that will improve health insurance coverage increasefederal research funding support early detection and increase access toclinical trials
3 Funding patient navigation programs that guide women through the healthcare continuum which includes locating financial resources and addressingbarriers such as cost of care
Komen also offers information about resources to help with financial barriers tobreast cancer care
Komen Advocacy
In a March Komen blog Komen AIS member Mona Jaffe Rowe discussed heradvocacy efforts in Maryland She spearheaded efforts to urge state law makers topass legislation requiring insurance companies to cover medically necessarydiagnostic imaging no less favorably than screening mammography Also in Marchrepresentatives from Affiliates Advocates in Science Komen Scholars and Komenstaff met in DC at Komenrsquos annual Advocacy Summit to encourage policymakers tomake breast cancer a priority Sign up here to stay up-to-date on Komens publicpolicy and advocacy efforts
Representatives from Affiliates Advocates in Science Komen Scholars Komen staff community
members and breast cancer survivors at Komenrsquos annual Advocacy Summit on March 21-23 2018
(Left to right) Komen Scholar Hari Nakshatri PhD Komen Central Indiana Affiliate Mission
Director Stephanie Laskey Komen Evansville Tri-State Executive Director Sheila Seiler Indiana
Senator Todd Young and Komen Research Review Manager Andrew Smith PhD meet on Capitol
Hill at the Komen Advocacy Summit in March
Alongside the Advocacy Summit the Komen Health Equity team hosted anAdvocacy training pilot called lsquoSpeak Truth to Powerrsquo where Komen communitystakeholders Affiliates and staff gathered to collectively discuss how far wersquove comeand to collaboratively plan where we are going The program included severalspeakers in the advocacy field collective discussions and Hill Day visits The HealthEquity team would like to thank the generous funders of this event the Fund IIFoundation and Pfizer for making the pilot training such a success
Gaining New Ground in Breast CancerResearch
In a recent Komen blogChief ScientificAdvisors George SledgeMD and JenniferPietenpol PhD talkabout the state of breastcancer research what wemay have missed in 2017whatrsquos exciting now andhow Komen is poised totackle the most excitingand important questions inbreast cancer
Komenrsquos Global and Local Outreach toAddress Metastatic Breast Cancer (MBC)
KomenPfizer Partnership is Bringing Effective Solutions for MBC
Pfizer the European School of Oncology (ESO) the Advanced Breast Cancer ThirdInternational Consensus Conference (ABC3) and leaders in the MBC community(including Komen) collaborated to pull together a report on the global analysis ofMBC spanning a decade (2005 ndash 2015) The report recently published in TheBreast calls attention to the gaps in care resources and support for MBC patients indifferent parts of the world
Unfortunately in lower
income countries about50-80 percent of patientsare diagnosed with latestage breast cancer(stage III or IV) comparedto 10-15 percent ofdiagnoses in high-incomecountries (like the US) Therefore Komen andPfizer have partnered totake on the global burdenof MBC You can readmore about progress andfuture goals of this effortin a recent Komen blog
KomenPfizer Partnership for Local Education about MBC
As an extension of this partnership Komen and Pfizer have teamed up to supporteducational programs for those living with MBC and their caregivers in the USSpecifically Pfizer is donating $500000 in support of MBC programming at KomenAffiliates Through May 31 2018 Affiliates are encouraged to submit applications forfunding which can include evidence-based patient-focused conferences events andother activities designed to educate the MBC community at the local level Learnmore here
Komenrsquos Work in Tanzania
Komen and the Tanzania Ministry of Health with input from global health and civilsociety experts have developed National Guidelines for Early Diagnosis of BreastCancer and Referral for Treatment in Tanzania The new guidelines are vital toaddressing breast cancer in Tanzania ndash a country where about 80 percent of womenare diagnosed with late-stage disease when treatment options are limited Learnmore in a new Komen Press Release
Upcoming Research FundingOpportunities
Komen will continue its research investment in early career breast cancerresearchers The new Request for Applications (RFAs) will be posted in the nextmonth or two on our Funding Opportunities page Stay tuned
Komen-funded young investigator Toni Celia-Terrassa PhD (left) and Komen Scholar YibinKang PhD (right) in the lab at Princeton University
Komen Kudos
Komen-funded grantee Lisa Coussens PhD was honored with the 12thAACR-Princess Takamatsu Memorial Lectureship for her impactful work on theimmune response in cancerFormer Komen Scholars Lori Pierce MD and Julie Gralow MD willbe honored as leaders in oncology at the 2018 American Association ofClinical Oncology (ASCO) meeting in June Dr Pierce will be given theHologic Inc Endowed Women Who Conquer Cancer Mentorship Award amp DrGralow will be given the Humanitarian AwardKomen-funded grantee Nikhil Wagle MD and his teamrsquos work presented atthe 2018 American Association for Cancer Research (AACR) Annual Meetingwas featured in The ASCO Post This works shows we are movingtoward improving clinical care for individuals with MBC Komen partner Metro Elevator raised over $174000 for breast cancerresearch Thank you Metro ElevatorDaniel Stover MD a Komen grant recipient funded by AmericanAirlines was named The Ohio State University May Physician of the Month
Research Snapshots
If cancer cells are found in the lymphnode does that mean they can spreadto distant organs Experts still debatethis Using imaging techniques a teamof scientists including formerKomen grantee Giorgio SeanoPhDco-authored a publication
in Science showing that cancer cellsthat have spread to a nearby lymphnode can invade the blood stream andspread (or metastasize) to otherorgans
Although triple negative breast cancer(TNBC) can be treated we stilllack effective targeted treatments forthis aggressive subtype In a Komen-funded study published in NatureMedicine Thomas (Trey) WestbrookPhD and colleagues discovered newTNBC therapeutic targets andstrategies which will soon be tested inthe clinic Learn more about theseimportant results here
According to a recent study publishedin Clinical Cancer Research higherlymphocyte counts predict lowermortality in early-stage TNBCsuggesting that higher immunefunction improves treatmenteffectiveness in this patient populationKomen-funded researchers thatcontributed to these findings includefirst author Anosheh AfghahiMD (pictured left) Christina CurtisPhD Chief Scientific Advisor GeorgeSledge MD Komen Scholar MelindaTelli MD and former KomenScholar Sunil Badve MD Morecoverage of this study can befound here
New strategies to block the return of breast cancer are desperately needed toimprove patient outcomes In a Komen-funded study recently publishedin Nature Subhamoy Dasgupta PhD former Komen Scholar Bert OrsquoMalleyMD and their team identified two proteins involved in metabolism that could be
targeted to stop tumor recurrence andor prevent breast cancer metastasis You canread more here
In a new Journal of ClinicalInvestigation publication Komen-funded grantee Weibo Lou PhD andteam show that a protein calledZMYND8 helps estrogen receptor (ER)-positive breast cancers survive andgrow in a low-oxygen environment andmay be a target to treat MBC You canread more about this exciting data
In a recent NatureCommunications publication DanielMcGrail PhD and colleagues showthat cytokine release (mediated by theDNA damage response protein ATM) isa primary driver of T-cell infiltration intoa tumor ndash a characteristic that candictate response to immunotherapies
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email us
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
Sohrab Shah PhD Memorial Sloan Kettering Cancer Center
New York NY (cancer genomics computational
biology bioinformatics)
Meryl Weinreb MA Advocates in Science Steering
Committee Landenberg PA (survivor research advocacy)
Two long-standing Komen Scholars will continue their service with Komen as newmembers of the Scientific Advisory Board (SAB) joining 6 continuing members
Lisa Carey MD of the University ofNorth Carolina LinebergerComprehensive Cancer Center ChapelHill NC has been a Komen Scholarsince 2010 and brings expertise inclinical research molecular sub-typesof breast cancer and treatmentresponse to the SAB
Sandy Finestone PsyD a KomenAdvocate in Science (AIS) from CostaMesa CA is a 30+ year breast cancersurvivor and research advocate andhas been a volunteer with Susan GKomen for over 25 years She bringsknowledge in patient support andresearch advocacy to the SAB
We congratulate and thank all our Mission Advisors as we continue to move towardsour Bold Goal of reducing breast cancer deaths by 50 in the US by 2026
Komen is Addressing Health Equity
Breast cancer deaths rates are about40 percent higher for black women inthe US compared to white women Inan April US News amp WorldReport article Komen President andCEO Paula Schneider outlines theinjustice of barriers to breast cancercare and Komenrsquos drive for healthequity through our African-AmericanHealth Equity Initiative and our BoldGoal
Komen is aiming to improve our understanding of health equity by funding researchthat will investigate some of the causes of health disparities A recent Journal ofClinical Oncology publication co-authored by Stephanie Wheeler PhD Komen-funded grantee Katherine Reeder-Hayes MD and Komen SAB member LisaCarey MD shows that increased financial strain on African-American women maycontribute to higher stress lower treatment compliance and worse breast canceroutcomes Komen is working to address financial barriers to care by
1 Providing financial aid to breast cancer patients through the Komen NationalTreatment Assistant Program Learn more by calling our National Breast CareHelpline at 1-877 GO KOMEN open daily from 900 am to 1000 pm ET orby emailing the helpline at helplinekomenorg
2 Advocating for policies that will improve health insurance coverage increasefederal research funding support early detection and increase access toclinical trials
3 Funding patient navigation programs that guide women through the healthcare continuum which includes locating financial resources and addressingbarriers such as cost of care
Komen also offers information about resources to help with financial barriers tobreast cancer care
Komen Advocacy
In a March Komen blog Komen AIS member Mona Jaffe Rowe discussed heradvocacy efforts in Maryland She spearheaded efforts to urge state law makers topass legislation requiring insurance companies to cover medically necessarydiagnostic imaging no less favorably than screening mammography Also in Marchrepresentatives from Affiliates Advocates in Science Komen Scholars and Komenstaff met in DC at Komenrsquos annual Advocacy Summit to encourage policymakers tomake breast cancer a priority Sign up here to stay up-to-date on Komens publicpolicy and advocacy efforts
Representatives from Affiliates Advocates in Science Komen Scholars Komen staff community
members and breast cancer survivors at Komenrsquos annual Advocacy Summit on March 21-23 2018
(Left to right) Komen Scholar Hari Nakshatri PhD Komen Central Indiana Affiliate Mission
Director Stephanie Laskey Komen Evansville Tri-State Executive Director Sheila Seiler Indiana
Senator Todd Young and Komen Research Review Manager Andrew Smith PhD meet on Capitol
Hill at the Komen Advocacy Summit in March
Alongside the Advocacy Summit the Komen Health Equity team hosted anAdvocacy training pilot called lsquoSpeak Truth to Powerrsquo where Komen communitystakeholders Affiliates and staff gathered to collectively discuss how far wersquove comeand to collaboratively plan where we are going The program included severalspeakers in the advocacy field collective discussions and Hill Day visits The HealthEquity team would like to thank the generous funders of this event the Fund IIFoundation and Pfizer for making the pilot training such a success
Gaining New Ground in Breast CancerResearch
In a recent Komen blogChief ScientificAdvisors George SledgeMD and JenniferPietenpol PhD talkabout the state of breastcancer research what wemay have missed in 2017whatrsquos exciting now andhow Komen is poised totackle the most excitingand important questions inbreast cancer
Komenrsquos Global and Local Outreach toAddress Metastatic Breast Cancer (MBC)
KomenPfizer Partnership is Bringing Effective Solutions for MBC
Pfizer the European School of Oncology (ESO) the Advanced Breast Cancer ThirdInternational Consensus Conference (ABC3) and leaders in the MBC community(including Komen) collaborated to pull together a report on the global analysis ofMBC spanning a decade (2005 ndash 2015) The report recently published in TheBreast calls attention to the gaps in care resources and support for MBC patients indifferent parts of the world
Unfortunately in lower
income countries about50-80 percent of patientsare diagnosed with latestage breast cancer(stage III or IV) comparedto 10-15 percent ofdiagnoses in high-incomecountries (like the US) Therefore Komen andPfizer have partnered totake on the global burdenof MBC You can readmore about progress andfuture goals of this effortin a recent Komen blog
KomenPfizer Partnership for Local Education about MBC
As an extension of this partnership Komen and Pfizer have teamed up to supporteducational programs for those living with MBC and their caregivers in the USSpecifically Pfizer is donating $500000 in support of MBC programming at KomenAffiliates Through May 31 2018 Affiliates are encouraged to submit applications forfunding which can include evidence-based patient-focused conferences events andother activities designed to educate the MBC community at the local level Learnmore here
Komenrsquos Work in Tanzania
Komen and the Tanzania Ministry of Health with input from global health and civilsociety experts have developed National Guidelines for Early Diagnosis of BreastCancer and Referral for Treatment in Tanzania The new guidelines are vital toaddressing breast cancer in Tanzania ndash a country where about 80 percent of womenare diagnosed with late-stage disease when treatment options are limited Learnmore in a new Komen Press Release
Upcoming Research FundingOpportunities
Komen will continue its research investment in early career breast cancerresearchers The new Request for Applications (RFAs) will be posted in the nextmonth or two on our Funding Opportunities page Stay tuned
Komen-funded young investigator Toni Celia-Terrassa PhD (left) and Komen Scholar YibinKang PhD (right) in the lab at Princeton University
Komen Kudos
Komen-funded grantee Lisa Coussens PhD was honored with the 12thAACR-Princess Takamatsu Memorial Lectureship for her impactful work on theimmune response in cancerFormer Komen Scholars Lori Pierce MD and Julie Gralow MD willbe honored as leaders in oncology at the 2018 American Association ofClinical Oncology (ASCO) meeting in June Dr Pierce will be given theHologic Inc Endowed Women Who Conquer Cancer Mentorship Award amp DrGralow will be given the Humanitarian AwardKomen-funded grantee Nikhil Wagle MD and his teamrsquos work presented atthe 2018 American Association for Cancer Research (AACR) Annual Meetingwas featured in The ASCO Post This works shows we are movingtoward improving clinical care for individuals with MBC Komen partner Metro Elevator raised over $174000 for breast cancerresearch Thank you Metro ElevatorDaniel Stover MD a Komen grant recipient funded by AmericanAirlines was named The Ohio State University May Physician of the Month
Research Snapshots
If cancer cells are found in the lymphnode does that mean they can spreadto distant organs Experts still debatethis Using imaging techniques a teamof scientists including formerKomen grantee Giorgio SeanoPhDco-authored a publication
in Science showing that cancer cellsthat have spread to a nearby lymphnode can invade the blood stream andspread (or metastasize) to otherorgans
Although triple negative breast cancer(TNBC) can be treated we stilllack effective targeted treatments forthis aggressive subtype In a Komen-funded study published in NatureMedicine Thomas (Trey) WestbrookPhD and colleagues discovered newTNBC therapeutic targets andstrategies which will soon be tested inthe clinic Learn more about theseimportant results here
According to a recent study publishedin Clinical Cancer Research higherlymphocyte counts predict lowermortality in early-stage TNBCsuggesting that higher immunefunction improves treatmenteffectiveness in this patient populationKomen-funded researchers thatcontributed to these findings includefirst author Anosheh AfghahiMD (pictured left) Christina CurtisPhD Chief Scientific Advisor GeorgeSledge MD Komen Scholar MelindaTelli MD and former KomenScholar Sunil Badve MD Morecoverage of this study can befound here
New strategies to block the return of breast cancer are desperately needed toimprove patient outcomes In a Komen-funded study recently publishedin Nature Subhamoy Dasgupta PhD former Komen Scholar Bert OrsquoMalleyMD and their team identified two proteins involved in metabolism that could be
targeted to stop tumor recurrence andor prevent breast cancer metastasis You canread more here
In a new Journal of ClinicalInvestigation publication Komen-funded grantee Weibo Lou PhD andteam show that a protein calledZMYND8 helps estrogen receptor (ER)-positive breast cancers survive andgrow in a low-oxygen environment andmay be a target to treat MBC You canread more about this exciting data
In a recent NatureCommunications publication DanielMcGrail PhD and colleagues showthat cytokine release (mediated by theDNA damage response protein ATM) isa primary driver of T-cell infiltration intoa tumor ndash a characteristic that candictate response to immunotherapies
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email us
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
We congratulate and thank all our Mission Advisors as we continue to move towardsour Bold Goal of reducing breast cancer deaths by 50 in the US by 2026
Komen is Addressing Health Equity
Breast cancer deaths rates are about40 percent higher for black women inthe US compared to white women Inan April US News amp WorldReport article Komen President andCEO Paula Schneider outlines theinjustice of barriers to breast cancercare and Komenrsquos drive for healthequity through our African-AmericanHealth Equity Initiative and our BoldGoal
Komen is aiming to improve our understanding of health equity by funding researchthat will investigate some of the causes of health disparities A recent Journal ofClinical Oncology publication co-authored by Stephanie Wheeler PhD Komen-funded grantee Katherine Reeder-Hayes MD and Komen SAB member LisaCarey MD shows that increased financial strain on African-American women maycontribute to higher stress lower treatment compliance and worse breast canceroutcomes Komen is working to address financial barriers to care by
1 Providing financial aid to breast cancer patients through the Komen NationalTreatment Assistant Program Learn more by calling our National Breast CareHelpline at 1-877 GO KOMEN open daily from 900 am to 1000 pm ET orby emailing the helpline at helplinekomenorg
2 Advocating for policies that will improve health insurance coverage increasefederal research funding support early detection and increase access toclinical trials
3 Funding patient navigation programs that guide women through the healthcare continuum which includes locating financial resources and addressingbarriers such as cost of care
Komen also offers information about resources to help with financial barriers tobreast cancer care
Komen Advocacy
In a March Komen blog Komen AIS member Mona Jaffe Rowe discussed heradvocacy efforts in Maryland She spearheaded efforts to urge state law makers topass legislation requiring insurance companies to cover medically necessarydiagnostic imaging no less favorably than screening mammography Also in Marchrepresentatives from Affiliates Advocates in Science Komen Scholars and Komenstaff met in DC at Komenrsquos annual Advocacy Summit to encourage policymakers tomake breast cancer a priority Sign up here to stay up-to-date on Komens publicpolicy and advocacy efforts
Representatives from Affiliates Advocates in Science Komen Scholars Komen staff community
members and breast cancer survivors at Komenrsquos annual Advocacy Summit on March 21-23 2018
(Left to right) Komen Scholar Hari Nakshatri PhD Komen Central Indiana Affiliate Mission
Director Stephanie Laskey Komen Evansville Tri-State Executive Director Sheila Seiler Indiana
Senator Todd Young and Komen Research Review Manager Andrew Smith PhD meet on Capitol
Hill at the Komen Advocacy Summit in March
Alongside the Advocacy Summit the Komen Health Equity team hosted anAdvocacy training pilot called lsquoSpeak Truth to Powerrsquo where Komen communitystakeholders Affiliates and staff gathered to collectively discuss how far wersquove comeand to collaboratively plan where we are going The program included severalspeakers in the advocacy field collective discussions and Hill Day visits The HealthEquity team would like to thank the generous funders of this event the Fund IIFoundation and Pfizer for making the pilot training such a success
Gaining New Ground in Breast CancerResearch
In a recent Komen blogChief ScientificAdvisors George SledgeMD and JenniferPietenpol PhD talkabout the state of breastcancer research what wemay have missed in 2017whatrsquos exciting now andhow Komen is poised totackle the most excitingand important questions inbreast cancer
Komenrsquos Global and Local Outreach toAddress Metastatic Breast Cancer (MBC)
KomenPfizer Partnership is Bringing Effective Solutions for MBC
Pfizer the European School of Oncology (ESO) the Advanced Breast Cancer ThirdInternational Consensus Conference (ABC3) and leaders in the MBC community(including Komen) collaborated to pull together a report on the global analysis ofMBC spanning a decade (2005 ndash 2015) The report recently published in TheBreast calls attention to the gaps in care resources and support for MBC patients indifferent parts of the world
Unfortunately in lower
income countries about50-80 percent of patientsare diagnosed with latestage breast cancer(stage III or IV) comparedto 10-15 percent ofdiagnoses in high-incomecountries (like the US) Therefore Komen andPfizer have partnered totake on the global burdenof MBC You can readmore about progress andfuture goals of this effortin a recent Komen blog
KomenPfizer Partnership for Local Education about MBC
As an extension of this partnership Komen and Pfizer have teamed up to supporteducational programs for those living with MBC and their caregivers in the USSpecifically Pfizer is donating $500000 in support of MBC programming at KomenAffiliates Through May 31 2018 Affiliates are encouraged to submit applications forfunding which can include evidence-based patient-focused conferences events andother activities designed to educate the MBC community at the local level Learnmore here
Komenrsquos Work in Tanzania
Komen and the Tanzania Ministry of Health with input from global health and civilsociety experts have developed National Guidelines for Early Diagnosis of BreastCancer and Referral for Treatment in Tanzania The new guidelines are vital toaddressing breast cancer in Tanzania ndash a country where about 80 percent of womenare diagnosed with late-stage disease when treatment options are limited Learnmore in a new Komen Press Release
Upcoming Research FundingOpportunities
Komen will continue its research investment in early career breast cancerresearchers The new Request for Applications (RFAs) will be posted in the nextmonth or two on our Funding Opportunities page Stay tuned
Komen-funded young investigator Toni Celia-Terrassa PhD (left) and Komen Scholar YibinKang PhD (right) in the lab at Princeton University
Komen Kudos
Komen-funded grantee Lisa Coussens PhD was honored with the 12thAACR-Princess Takamatsu Memorial Lectureship for her impactful work on theimmune response in cancerFormer Komen Scholars Lori Pierce MD and Julie Gralow MD willbe honored as leaders in oncology at the 2018 American Association ofClinical Oncology (ASCO) meeting in June Dr Pierce will be given theHologic Inc Endowed Women Who Conquer Cancer Mentorship Award amp DrGralow will be given the Humanitarian AwardKomen-funded grantee Nikhil Wagle MD and his teamrsquos work presented atthe 2018 American Association for Cancer Research (AACR) Annual Meetingwas featured in The ASCO Post This works shows we are movingtoward improving clinical care for individuals with MBC Komen partner Metro Elevator raised over $174000 for breast cancerresearch Thank you Metro ElevatorDaniel Stover MD a Komen grant recipient funded by AmericanAirlines was named The Ohio State University May Physician of the Month
Research Snapshots
If cancer cells are found in the lymphnode does that mean they can spreadto distant organs Experts still debatethis Using imaging techniques a teamof scientists including formerKomen grantee Giorgio SeanoPhDco-authored a publication
in Science showing that cancer cellsthat have spread to a nearby lymphnode can invade the blood stream andspread (or metastasize) to otherorgans
Although triple negative breast cancer(TNBC) can be treated we stilllack effective targeted treatments forthis aggressive subtype In a Komen-funded study published in NatureMedicine Thomas (Trey) WestbrookPhD and colleagues discovered newTNBC therapeutic targets andstrategies which will soon be tested inthe clinic Learn more about theseimportant results here
According to a recent study publishedin Clinical Cancer Research higherlymphocyte counts predict lowermortality in early-stage TNBCsuggesting that higher immunefunction improves treatmenteffectiveness in this patient populationKomen-funded researchers thatcontributed to these findings includefirst author Anosheh AfghahiMD (pictured left) Christina CurtisPhD Chief Scientific Advisor GeorgeSledge MD Komen Scholar MelindaTelli MD and former KomenScholar Sunil Badve MD Morecoverage of this study can befound here
New strategies to block the return of breast cancer are desperately needed toimprove patient outcomes In a Komen-funded study recently publishedin Nature Subhamoy Dasgupta PhD former Komen Scholar Bert OrsquoMalleyMD and their team identified two proteins involved in metabolism that could be
targeted to stop tumor recurrence andor prevent breast cancer metastasis You canread more here
In a new Journal of ClinicalInvestigation publication Komen-funded grantee Weibo Lou PhD andteam show that a protein calledZMYND8 helps estrogen receptor (ER)-positive breast cancers survive andgrow in a low-oxygen environment andmay be a target to treat MBC You canread more about this exciting data
In a recent NatureCommunications publication DanielMcGrail PhD and colleagues showthat cytokine release (mediated by theDNA damage response protein ATM) isa primary driver of T-cell infiltration intoa tumor ndash a characteristic that candictate response to immunotherapies
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email us
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
Representatives from Affiliates Advocates in Science Komen Scholars Komen staff community
members and breast cancer survivors at Komenrsquos annual Advocacy Summit on March 21-23 2018
(Left to right) Komen Scholar Hari Nakshatri PhD Komen Central Indiana Affiliate Mission
Director Stephanie Laskey Komen Evansville Tri-State Executive Director Sheila Seiler Indiana
Senator Todd Young and Komen Research Review Manager Andrew Smith PhD meet on Capitol
Hill at the Komen Advocacy Summit in March
Alongside the Advocacy Summit the Komen Health Equity team hosted anAdvocacy training pilot called lsquoSpeak Truth to Powerrsquo where Komen communitystakeholders Affiliates and staff gathered to collectively discuss how far wersquove comeand to collaboratively plan where we are going The program included severalspeakers in the advocacy field collective discussions and Hill Day visits The HealthEquity team would like to thank the generous funders of this event the Fund IIFoundation and Pfizer for making the pilot training such a success
Gaining New Ground in Breast CancerResearch
In a recent Komen blogChief ScientificAdvisors George SledgeMD and JenniferPietenpol PhD talkabout the state of breastcancer research what wemay have missed in 2017whatrsquos exciting now andhow Komen is poised totackle the most excitingand important questions inbreast cancer
Komenrsquos Global and Local Outreach toAddress Metastatic Breast Cancer (MBC)
KomenPfizer Partnership is Bringing Effective Solutions for MBC
Pfizer the European School of Oncology (ESO) the Advanced Breast Cancer ThirdInternational Consensus Conference (ABC3) and leaders in the MBC community(including Komen) collaborated to pull together a report on the global analysis ofMBC spanning a decade (2005 ndash 2015) The report recently published in TheBreast calls attention to the gaps in care resources and support for MBC patients indifferent parts of the world
Unfortunately in lower
income countries about50-80 percent of patientsare diagnosed with latestage breast cancer(stage III or IV) comparedto 10-15 percent ofdiagnoses in high-incomecountries (like the US) Therefore Komen andPfizer have partnered totake on the global burdenof MBC You can readmore about progress andfuture goals of this effortin a recent Komen blog
KomenPfizer Partnership for Local Education about MBC
As an extension of this partnership Komen and Pfizer have teamed up to supporteducational programs for those living with MBC and their caregivers in the USSpecifically Pfizer is donating $500000 in support of MBC programming at KomenAffiliates Through May 31 2018 Affiliates are encouraged to submit applications forfunding which can include evidence-based patient-focused conferences events andother activities designed to educate the MBC community at the local level Learnmore here
Komenrsquos Work in Tanzania
Komen and the Tanzania Ministry of Health with input from global health and civilsociety experts have developed National Guidelines for Early Diagnosis of BreastCancer and Referral for Treatment in Tanzania The new guidelines are vital toaddressing breast cancer in Tanzania ndash a country where about 80 percent of womenare diagnosed with late-stage disease when treatment options are limited Learnmore in a new Komen Press Release
Upcoming Research FundingOpportunities
Komen will continue its research investment in early career breast cancerresearchers The new Request for Applications (RFAs) will be posted in the nextmonth or two on our Funding Opportunities page Stay tuned
Komen-funded young investigator Toni Celia-Terrassa PhD (left) and Komen Scholar YibinKang PhD (right) in the lab at Princeton University
Komen Kudos
Komen-funded grantee Lisa Coussens PhD was honored with the 12thAACR-Princess Takamatsu Memorial Lectureship for her impactful work on theimmune response in cancerFormer Komen Scholars Lori Pierce MD and Julie Gralow MD willbe honored as leaders in oncology at the 2018 American Association ofClinical Oncology (ASCO) meeting in June Dr Pierce will be given theHologic Inc Endowed Women Who Conquer Cancer Mentorship Award amp DrGralow will be given the Humanitarian AwardKomen-funded grantee Nikhil Wagle MD and his teamrsquos work presented atthe 2018 American Association for Cancer Research (AACR) Annual Meetingwas featured in The ASCO Post This works shows we are movingtoward improving clinical care for individuals with MBC Komen partner Metro Elevator raised over $174000 for breast cancerresearch Thank you Metro ElevatorDaniel Stover MD a Komen grant recipient funded by AmericanAirlines was named The Ohio State University May Physician of the Month
Research Snapshots
If cancer cells are found in the lymphnode does that mean they can spreadto distant organs Experts still debatethis Using imaging techniques a teamof scientists including formerKomen grantee Giorgio SeanoPhDco-authored a publication
in Science showing that cancer cellsthat have spread to a nearby lymphnode can invade the blood stream andspread (or metastasize) to otherorgans
Although triple negative breast cancer(TNBC) can be treated we stilllack effective targeted treatments forthis aggressive subtype In a Komen-funded study published in NatureMedicine Thomas (Trey) WestbrookPhD and colleagues discovered newTNBC therapeutic targets andstrategies which will soon be tested inthe clinic Learn more about theseimportant results here
According to a recent study publishedin Clinical Cancer Research higherlymphocyte counts predict lowermortality in early-stage TNBCsuggesting that higher immunefunction improves treatmenteffectiveness in this patient populationKomen-funded researchers thatcontributed to these findings includefirst author Anosheh AfghahiMD (pictured left) Christina CurtisPhD Chief Scientific Advisor GeorgeSledge MD Komen Scholar MelindaTelli MD and former KomenScholar Sunil Badve MD Morecoverage of this study can befound here
New strategies to block the return of breast cancer are desperately needed toimprove patient outcomes In a Komen-funded study recently publishedin Nature Subhamoy Dasgupta PhD former Komen Scholar Bert OrsquoMalleyMD and their team identified two proteins involved in metabolism that could be
targeted to stop tumor recurrence andor prevent breast cancer metastasis You canread more here
In a new Journal of ClinicalInvestigation publication Komen-funded grantee Weibo Lou PhD andteam show that a protein calledZMYND8 helps estrogen receptor (ER)-positive breast cancers survive andgrow in a low-oxygen environment andmay be a target to treat MBC You canread more about this exciting data
In a recent NatureCommunications publication DanielMcGrail PhD and colleagues showthat cytokine release (mediated by theDNA damage response protein ATM) isa primary driver of T-cell infiltration intoa tumor ndash a characteristic that candictate response to immunotherapies
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email us
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
Gaining New Ground in Breast CancerResearch
In a recent Komen blogChief ScientificAdvisors George SledgeMD and JenniferPietenpol PhD talkabout the state of breastcancer research what wemay have missed in 2017whatrsquos exciting now andhow Komen is poised totackle the most excitingand important questions inbreast cancer
Komenrsquos Global and Local Outreach toAddress Metastatic Breast Cancer (MBC)
KomenPfizer Partnership is Bringing Effective Solutions for MBC
Pfizer the European School of Oncology (ESO) the Advanced Breast Cancer ThirdInternational Consensus Conference (ABC3) and leaders in the MBC community(including Komen) collaborated to pull together a report on the global analysis ofMBC spanning a decade (2005 ndash 2015) The report recently published in TheBreast calls attention to the gaps in care resources and support for MBC patients indifferent parts of the world
Unfortunately in lower
income countries about50-80 percent of patientsare diagnosed with latestage breast cancer(stage III or IV) comparedto 10-15 percent ofdiagnoses in high-incomecountries (like the US) Therefore Komen andPfizer have partnered totake on the global burdenof MBC You can readmore about progress andfuture goals of this effortin a recent Komen blog
KomenPfizer Partnership for Local Education about MBC
As an extension of this partnership Komen and Pfizer have teamed up to supporteducational programs for those living with MBC and their caregivers in the USSpecifically Pfizer is donating $500000 in support of MBC programming at KomenAffiliates Through May 31 2018 Affiliates are encouraged to submit applications forfunding which can include evidence-based patient-focused conferences events andother activities designed to educate the MBC community at the local level Learnmore here
Komenrsquos Work in Tanzania
Komen and the Tanzania Ministry of Health with input from global health and civilsociety experts have developed National Guidelines for Early Diagnosis of BreastCancer and Referral for Treatment in Tanzania The new guidelines are vital toaddressing breast cancer in Tanzania ndash a country where about 80 percent of womenare diagnosed with late-stage disease when treatment options are limited Learnmore in a new Komen Press Release
Upcoming Research FundingOpportunities
Komen will continue its research investment in early career breast cancerresearchers The new Request for Applications (RFAs) will be posted in the nextmonth or two on our Funding Opportunities page Stay tuned
Komen-funded young investigator Toni Celia-Terrassa PhD (left) and Komen Scholar YibinKang PhD (right) in the lab at Princeton University
Komen Kudos
Komen-funded grantee Lisa Coussens PhD was honored with the 12thAACR-Princess Takamatsu Memorial Lectureship for her impactful work on theimmune response in cancerFormer Komen Scholars Lori Pierce MD and Julie Gralow MD willbe honored as leaders in oncology at the 2018 American Association ofClinical Oncology (ASCO) meeting in June Dr Pierce will be given theHologic Inc Endowed Women Who Conquer Cancer Mentorship Award amp DrGralow will be given the Humanitarian AwardKomen-funded grantee Nikhil Wagle MD and his teamrsquos work presented atthe 2018 American Association for Cancer Research (AACR) Annual Meetingwas featured in The ASCO Post This works shows we are movingtoward improving clinical care for individuals with MBC Komen partner Metro Elevator raised over $174000 for breast cancerresearch Thank you Metro ElevatorDaniel Stover MD a Komen grant recipient funded by AmericanAirlines was named The Ohio State University May Physician of the Month
Research Snapshots
If cancer cells are found in the lymphnode does that mean they can spreadto distant organs Experts still debatethis Using imaging techniques a teamof scientists including formerKomen grantee Giorgio SeanoPhDco-authored a publication
in Science showing that cancer cellsthat have spread to a nearby lymphnode can invade the blood stream andspread (or metastasize) to otherorgans
Although triple negative breast cancer(TNBC) can be treated we stilllack effective targeted treatments forthis aggressive subtype In a Komen-funded study published in NatureMedicine Thomas (Trey) WestbrookPhD and colleagues discovered newTNBC therapeutic targets andstrategies which will soon be tested inthe clinic Learn more about theseimportant results here
According to a recent study publishedin Clinical Cancer Research higherlymphocyte counts predict lowermortality in early-stage TNBCsuggesting that higher immunefunction improves treatmenteffectiveness in this patient populationKomen-funded researchers thatcontributed to these findings includefirst author Anosheh AfghahiMD (pictured left) Christina CurtisPhD Chief Scientific Advisor GeorgeSledge MD Komen Scholar MelindaTelli MD and former KomenScholar Sunil Badve MD Morecoverage of this study can befound here
New strategies to block the return of breast cancer are desperately needed toimprove patient outcomes In a Komen-funded study recently publishedin Nature Subhamoy Dasgupta PhD former Komen Scholar Bert OrsquoMalleyMD and their team identified two proteins involved in metabolism that could be
targeted to stop tumor recurrence andor prevent breast cancer metastasis You canread more here
In a new Journal of ClinicalInvestigation publication Komen-funded grantee Weibo Lou PhD andteam show that a protein calledZMYND8 helps estrogen receptor (ER)-positive breast cancers survive andgrow in a low-oxygen environment andmay be a target to treat MBC You canread more about this exciting data
In a recent NatureCommunications publication DanielMcGrail PhD and colleagues showthat cytokine release (mediated by theDNA damage response protein ATM) isa primary driver of T-cell infiltration intoa tumor ndash a characteristic that candictate response to immunotherapies
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email us
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
income countries about50-80 percent of patientsare diagnosed with latestage breast cancer(stage III or IV) comparedto 10-15 percent ofdiagnoses in high-incomecountries (like the US) Therefore Komen andPfizer have partnered totake on the global burdenof MBC You can readmore about progress andfuture goals of this effortin a recent Komen blog
KomenPfizer Partnership for Local Education about MBC
As an extension of this partnership Komen and Pfizer have teamed up to supporteducational programs for those living with MBC and their caregivers in the USSpecifically Pfizer is donating $500000 in support of MBC programming at KomenAffiliates Through May 31 2018 Affiliates are encouraged to submit applications forfunding which can include evidence-based patient-focused conferences events andother activities designed to educate the MBC community at the local level Learnmore here
Komenrsquos Work in Tanzania
Komen and the Tanzania Ministry of Health with input from global health and civilsociety experts have developed National Guidelines for Early Diagnosis of BreastCancer and Referral for Treatment in Tanzania The new guidelines are vital toaddressing breast cancer in Tanzania ndash a country where about 80 percent of womenare diagnosed with late-stage disease when treatment options are limited Learnmore in a new Komen Press Release
Upcoming Research FundingOpportunities
Komen will continue its research investment in early career breast cancerresearchers The new Request for Applications (RFAs) will be posted in the nextmonth or two on our Funding Opportunities page Stay tuned
Komen-funded young investigator Toni Celia-Terrassa PhD (left) and Komen Scholar YibinKang PhD (right) in the lab at Princeton University
Komen Kudos
Komen-funded grantee Lisa Coussens PhD was honored with the 12thAACR-Princess Takamatsu Memorial Lectureship for her impactful work on theimmune response in cancerFormer Komen Scholars Lori Pierce MD and Julie Gralow MD willbe honored as leaders in oncology at the 2018 American Association ofClinical Oncology (ASCO) meeting in June Dr Pierce will be given theHologic Inc Endowed Women Who Conquer Cancer Mentorship Award amp DrGralow will be given the Humanitarian AwardKomen-funded grantee Nikhil Wagle MD and his teamrsquos work presented atthe 2018 American Association for Cancer Research (AACR) Annual Meetingwas featured in The ASCO Post This works shows we are movingtoward improving clinical care for individuals with MBC Komen partner Metro Elevator raised over $174000 for breast cancerresearch Thank you Metro ElevatorDaniel Stover MD a Komen grant recipient funded by AmericanAirlines was named The Ohio State University May Physician of the Month
Research Snapshots
If cancer cells are found in the lymphnode does that mean they can spreadto distant organs Experts still debatethis Using imaging techniques a teamof scientists including formerKomen grantee Giorgio SeanoPhDco-authored a publication
in Science showing that cancer cellsthat have spread to a nearby lymphnode can invade the blood stream andspread (or metastasize) to otherorgans
Although triple negative breast cancer(TNBC) can be treated we stilllack effective targeted treatments forthis aggressive subtype In a Komen-funded study published in NatureMedicine Thomas (Trey) WestbrookPhD and colleagues discovered newTNBC therapeutic targets andstrategies which will soon be tested inthe clinic Learn more about theseimportant results here
According to a recent study publishedin Clinical Cancer Research higherlymphocyte counts predict lowermortality in early-stage TNBCsuggesting that higher immunefunction improves treatmenteffectiveness in this patient populationKomen-funded researchers thatcontributed to these findings includefirst author Anosheh AfghahiMD (pictured left) Christina CurtisPhD Chief Scientific Advisor GeorgeSledge MD Komen Scholar MelindaTelli MD and former KomenScholar Sunil Badve MD Morecoverage of this study can befound here
New strategies to block the return of breast cancer are desperately needed toimprove patient outcomes In a Komen-funded study recently publishedin Nature Subhamoy Dasgupta PhD former Komen Scholar Bert OrsquoMalleyMD and their team identified two proteins involved in metabolism that could be
targeted to stop tumor recurrence andor prevent breast cancer metastasis You canread more here
In a new Journal of ClinicalInvestigation publication Komen-funded grantee Weibo Lou PhD andteam show that a protein calledZMYND8 helps estrogen receptor (ER)-positive breast cancers survive andgrow in a low-oxygen environment andmay be a target to treat MBC You canread more about this exciting data
In a recent NatureCommunications publication DanielMcGrail PhD and colleagues showthat cytokine release (mediated by theDNA damage response protein ATM) isa primary driver of T-cell infiltration intoa tumor ndash a characteristic that candictate response to immunotherapies
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email us
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
Komen-funded young investigator Toni Celia-Terrassa PhD (left) and Komen Scholar YibinKang PhD (right) in the lab at Princeton University
Komen Kudos
Komen-funded grantee Lisa Coussens PhD was honored with the 12thAACR-Princess Takamatsu Memorial Lectureship for her impactful work on theimmune response in cancerFormer Komen Scholars Lori Pierce MD and Julie Gralow MD willbe honored as leaders in oncology at the 2018 American Association ofClinical Oncology (ASCO) meeting in June Dr Pierce will be given theHologic Inc Endowed Women Who Conquer Cancer Mentorship Award amp DrGralow will be given the Humanitarian AwardKomen-funded grantee Nikhil Wagle MD and his teamrsquos work presented atthe 2018 American Association for Cancer Research (AACR) Annual Meetingwas featured in The ASCO Post This works shows we are movingtoward improving clinical care for individuals with MBC Komen partner Metro Elevator raised over $174000 for breast cancerresearch Thank you Metro ElevatorDaniel Stover MD a Komen grant recipient funded by AmericanAirlines was named The Ohio State University May Physician of the Month
Research Snapshots
If cancer cells are found in the lymphnode does that mean they can spreadto distant organs Experts still debatethis Using imaging techniques a teamof scientists including formerKomen grantee Giorgio SeanoPhDco-authored a publication
in Science showing that cancer cellsthat have spread to a nearby lymphnode can invade the blood stream andspread (or metastasize) to otherorgans
Although triple negative breast cancer(TNBC) can be treated we stilllack effective targeted treatments forthis aggressive subtype In a Komen-funded study published in NatureMedicine Thomas (Trey) WestbrookPhD and colleagues discovered newTNBC therapeutic targets andstrategies which will soon be tested inthe clinic Learn more about theseimportant results here
According to a recent study publishedin Clinical Cancer Research higherlymphocyte counts predict lowermortality in early-stage TNBCsuggesting that higher immunefunction improves treatmenteffectiveness in this patient populationKomen-funded researchers thatcontributed to these findings includefirst author Anosheh AfghahiMD (pictured left) Christina CurtisPhD Chief Scientific Advisor GeorgeSledge MD Komen Scholar MelindaTelli MD and former KomenScholar Sunil Badve MD Morecoverage of this study can befound here
New strategies to block the return of breast cancer are desperately needed toimprove patient outcomes In a Komen-funded study recently publishedin Nature Subhamoy Dasgupta PhD former Komen Scholar Bert OrsquoMalleyMD and their team identified two proteins involved in metabolism that could be
targeted to stop tumor recurrence andor prevent breast cancer metastasis You canread more here
In a new Journal of ClinicalInvestigation publication Komen-funded grantee Weibo Lou PhD andteam show that a protein calledZMYND8 helps estrogen receptor (ER)-positive breast cancers survive andgrow in a low-oxygen environment andmay be a target to treat MBC You canread more about this exciting data
In a recent NatureCommunications publication DanielMcGrail PhD and colleagues showthat cytokine release (mediated by theDNA damage response protein ATM) isa primary driver of T-cell infiltration intoa tumor ndash a characteristic that candictate response to immunotherapies
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email us
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
in Science showing that cancer cellsthat have spread to a nearby lymphnode can invade the blood stream andspread (or metastasize) to otherorgans
Although triple negative breast cancer(TNBC) can be treated we stilllack effective targeted treatments forthis aggressive subtype In a Komen-funded study published in NatureMedicine Thomas (Trey) WestbrookPhD and colleagues discovered newTNBC therapeutic targets andstrategies which will soon be tested inthe clinic Learn more about theseimportant results here
According to a recent study publishedin Clinical Cancer Research higherlymphocyte counts predict lowermortality in early-stage TNBCsuggesting that higher immunefunction improves treatmenteffectiveness in this patient populationKomen-funded researchers thatcontributed to these findings includefirst author Anosheh AfghahiMD (pictured left) Christina CurtisPhD Chief Scientific Advisor GeorgeSledge MD Komen Scholar MelindaTelli MD and former KomenScholar Sunil Badve MD Morecoverage of this study can befound here
New strategies to block the return of breast cancer are desperately needed toimprove patient outcomes In a Komen-funded study recently publishedin Nature Subhamoy Dasgupta PhD former Komen Scholar Bert OrsquoMalleyMD and their team identified two proteins involved in metabolism that could be
targeted to stop tumor recurrence andor prevent breast cancer metastasis You canread more here
In a new Journal of ClinicalInvestigation publication Komen-funded grantee Weibo Lou PhD andteam show that a protein calledZMYND8 helps estrogen receptor (ER)-positive breast cancers survive andgrow in a low-oxygen environment andmay be a target to treat MBC You canread more about this exciting data
In a recent NatureCommunications publication DanielMcGrail PhD and colleagues showthat cytokine release (mediated by theDNA damage response protein ATM) isa primary driver of T-cell infiltration intoa tumor ndash a characteristic that candictate response to immunotherapies
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email us
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
targeted to stop tumor recurrence andor prevent breast cancer metastasis You canread more here
In a new Journal of ClinicalInvestigation publication Komen-funded grantee Weibo Lou PhD andteam show that a protein calledZMYND8 helps estrogen receptor (ER)-positive breast cancers survive andgrow in a low-oxygen environment andmay be a target to treat MBC You canread more about this exciting data
In a recent NatureCommunications publication DanielMcGrail PhD and colleagues showthat cytokine release (mediated by theDNA damage response protein ATM) isa primary driver of T-cell infiltration intoa tumor ndash a characteristic that candictate response to immunotherapies
If you have a recent or upcoming publication on your Komen-funded researchplease notify your Research Grants Manager or email us
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
at researchprogramskomenorg Your work could be featured in the nextnewsletter
Komen Research in the News
Reagan-Udall Foundation ndash This press release cites the need for accurateinformation around federal Right-To-Try legislation and the FDArsquos ExpandedAccess Navigator tool (which Komen helped develop)Sunlight Foundation ndash Following scrutiny of patient advocacy groups andmedia the governmentrsquos Office of Womenrsquos Health has restored a single pageof breast cancer information to its website Komen was among thoseorganizations weighing in after word that breast cancer information had beenremoved from the site Komen founder Nancy Brinker wrote about it in The HillClassycom ndash Komen Sr Vice President of Development Christina Alford has anew podcast on what motivates her to help people ldquoinvest in possibilityrdquoCancerToday ndash Komen SAB member Sandy Finestone PsyD discusses howpatients make decisions about breast surgery
Research Resources
Komen funding has generated numerous publicly available resources intended toadvance research Our readers are encouraged to use the below resources so wecan continue to move toward our goal of saving lives
The Komen Tissue Bank (KTB) at the Indiana University Simon Cancer Centeris the only repository in the world containing breast tissue and blood productsfrom women who do not show evidence of breast cancer Please contact theKTB directly if you are interested in using these samplesTNBCtype is a tool that allows you to sub-type TNBC using genomic dataKomen Chief Scientific Advisor Jennifer Pietenpol PhD and her team atVanderbilt University Medical Center developed this toolThe MBC Project (mbcprojectorg) is a patient-driven initiative that asks MBCpatients to share their cancer experiences medical records and tumor tissuesto accelerate research discoveries The project has released the first of manypublicly accessible data sets into cBioPortal and will soon be sharing raw datain the Genomic Data Commons (GDC) This includes de-identified genomicclinical and patient-reported data from 103 tumor samples from 78 patientsThe goal of this growing data set is to allow as many researchers as possibleto make discoveries that accelerate our understanding of MBC Find out moreat mbcprojectorgdata-release
Take a Walk with a Komen Researcher
Komen 3-Day events have been scheduled across the nation including AtlantaDallas-Fort Worth Michigan Philadelphia San Diego Seattle and the Twin Cities Ifyou cannot join us for the 3-day 60-mile journey then why not commit to 20 miles in
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
1 day The money raised will be used to save lives support community programsand make huge strides in breast cancer research You can support the work ofKomen-funded scientists like Carmen Bergom MD PhD YOU can make animpact one step at a time
Komen-funded grantee Carmen Bergom MD PhD trains graduate student Rachel Schlaak at
The Medical College of Wisconsin
Thank You for Your Support
We at Komen value the work our Affiliates do to address breast cancer every day intheir local communities YOU can contribute to this work by participating in anAffiliate event near you such as a Race For the Cure or More Than Pink WalkThank you for your continued support
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
Shirley Mertz Komen Advocate in Science President of the Metastatic Breast Cancer Network
founding member of the Metastatic Breast Cancer Alliance and one of the nations most influential
MBC advocates spoke at the Komen Wisconsin Affiliate MBC Symposium on May 1
Find similar local MBC events here
If you have recently participated in a Komen Affiliate or 3-Day event please sendphotos and a brief description to your Research Grant Manager or emailus researchprogramskomenorg Your photo may be featured in our nextnewsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professionalsocieties and academic institutions to support a number of patient-focused meetingsand scientific conferences each year Below is a list of Komen-sponsored meetings() as well as other conferences that may be of interest
American Association of Clinical Oncology (ASCO) Annual Meeting - June 1-52018 Chicago ILThe 17th Congress of the Metastasis Research Society amp Young InvestigatorSatellite Meeting - August 1-5 2018 Princeton University Princeton NJ
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences
Take Action
Like what yoursquore reading Wed loveyour support
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breastcancer news inspirational stories and more
Correction Issue 32 March 2018 Research Update Newsletter - Research Snapshots - Dr Hari Nakshatris paper
was mislabeled as a Nature publication but was an Oncogene publication The correction is printed here
Copyright Acirccopy 2018 Susan G Komenreg All rights reserved All Komen grantees receive this newsletter
Our mailing address is
Susan G Komenreg5005 LBJ FreewaySuite 526Dallas TX 75244 Add us to your address book unsubscribe from this list update subscription preferences