KNOWLEDGE ALERT Date: 23rd September 2016

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This bulletin highlights recently produced documents and items of interest that have appeared on websites (coverage may not be comprehensive). If you have any comments or suggestions regarding this Bulletin, please email the library library@sthk.nhs.uk. All links are correct at time of publishing. If a link is broken please email the library and we will send you the correct link/document. Some documents are large and may take time to open so please be patient when waiting for links to open. If you have received this bulletin from a third party and would like to receive it direct please email the library. Library Contact Details: Library and Knowledge Service, St Helens & Knowsley Health Informatics, Level 1 Nightingale House, Whiston Hospital, Warrington Road, Prescot, Merseyside L35 5DR www.knowledge-nw.nhs.uk

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CONTENTS:

ALLIED HEALTH PROFESSIONALS CANCER CARDIOLOGY CHILDREN & YOUNG PEOPLE COMMISSIONING DIABETES DIAGNOSTICS EMERGENCY MEDICINE/CRITICAL CARE GASTROENTEROLOGY GENERAL MEDICINE GENERAL PRACTICE AND PRACTICE MANAGEMENT HEALTH SERVICES MANAGEMENT IMMUNISATION INFECTION CONTROL AND INFECTIOUS DISEASES INFORMATICS AND INFORMATION GOVERNANCE MATERNITY & GYNAECOLOGY MEDICINES MANAGEMENT/PHARMACY MENTAL HEALTH AND WELLBEING NEUROLOGY NURSING PRACTICE

OPHTHALMOLOGY PATHOLOGY PUBLIC HEALTH/HEALTH IMPROVEMENT RESEARCH

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ALLIED HEALTH PROFESSIONALS New Nutrition Labels Will Do Little to Bring Quality to American Diet Blog from: Deborah A. Cohen, Senior Natural Scientist, Rand Corporation. Blog: http://www.rand.org/blog/2016/08/new-nutrition-labels-will-do-little-to-bring-quality.html Testing Ecopipam's effectiveness in treating stuttering Stuttering affects about three million Americans. Currently, no Food and Drug Administration (FDA)-approved drug treatments are available. In an attempt to find a new medicine, a research team will conduct a study to determine how effective ecopipam, an orally administered medication, is as treatment against stuttering. News: https://www.sciencedaily.com/releases/2016/09/160922085741.htm

CANCER Shedding light on the mutational landscape of the most common paediatric cancer A group of researchers from Columbia University, Rutgers University, and institutions in Europe and Japan have identified genomic alterations in paediatric relapsed acute lymphoblastic leukaemia (ALL) that cause both therapy resistance and improved clinical response to multi-agent chemotherapy treatment. News: https://www.sciencedaily.com/releases/2016/09/160921155653.htm Abstract: http://www.pnas.org/content/early/2016/09/20/1608420113.abstract New strategy identified for treating acute myeloid leukaemia (AML) A promising new approach to the treatment of AML has been discovered by a team of researchers. In their report, the investigators have identified a crucial dysfunction in blood cell development that underlies AML and show that inhibiting the action of a specific enzyme prompts the differentiation of leukemic cells, reducing their number and decreasing their ability to propagate the cancer. News: https://www.sciencedaily.com/releases/2016/09/160921155846.htm Abstract: http://www.cell.com/cell/abstract/S0092-8674(16)31154-0 Exercise for women receiving adjuvant therapy for breast cancer The authors of this review conclude that aerobic and resistance exercise can be regarded as beneficial for individuals with adjuvant therapy-related side effects. Further research is required to determine the optimal type, intensity, and timing of an exercise intervention. Cochrane review: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005001.pub3/full AltaBioscience announces UKAS accreditation of new 'hormone fingerprint' test: application as an aid to diagnosis of adrenal cancer A new analytical test has been launched in the UK that provides sensitive, specific and efficient predictive analysis of a rare form of cancer from a simple urine sample. The steroid profiling test is expected to improve diagnosis for adrenocortical carcinoma (ACC). News: http://www.birmingham.ac.uk/news/latest/2016/09/altabioscience-announces-application-aid-diagnosis-of-adrenal-cancer.aspx Artificial intelligence reveals mechanism behind brain tumour Researchers have used computer modelling to study how brain tumours arise. The study illustrated how researchers in the future will be able to use large-scale data to find new disease mechanisms and identify new treatment targets. News: http://ecancer.org/news/10136-artificial-intelligence-reveals-mechanism-behind-brain-tumour.php Abstract: http://www.ebiomedicine.com/article/S2352-3964(16)30407-8/abstract Full text article (PDF): http://www.ebiomedicine.com/article/S2352-3964(16)30407-8/pdf

Precision medicine trial first of its kind to show benefit to patients A clinical trial for types of advanced cancer is the first of its kind to show that precision medicine – or tailoring treatment for individual people – can slow down the time it takes for a tumour to grow back, according to research presented at the Molecular Analysis for Personalised Therapy (MAP) conference. Press release: http://www.cancerresearchuk.org/about-us/cancer-news/press-release/2016-09-23-precision-medicine-trial-first-of-its-kind-to-show-benefit-to-patients

CARDIOLOGY Smoking has a very broad, long-lasting impact on the human genome Smoking leaves its "footprint" on the human genome in the form of deoxyribonucleic acid (DNA) methylation, a process by which cells control gene activity, according to new research. Even after someone stops smoking, the effects of smoking remain in their DNA. News: https://www.sciencedaily.com/releases/2016/09/160921215106.htm Abstract: http://circgenetics.ahajournals.org/content/early/2016/09/14/CIRCGENETICS.116.001506.abstract

CHILDREN & YOUNG PEOPLE 50-country comparison of child and youth fitness levels: Insightful look at population health An international research team studied the aerobic fitness levels of children and youth across 50 countries. The study involved analysing 20-meter shuttle data, also called the beep test, from 1.1 million kids aged 9 to 17 years old from 50 countries. The beep test is the most popular field-based test of aerobic fitness levels of children and youth. It is also standardized and commonly used around the world. Tanzania came top, the UK came 17th out of 50, the USA placed 47 out of 50 with Mexico being the least fit. NB: The full text is available by logging in with OpenAthens News: http://www.cheori.org/en/newsreleases?newsid=1407 Abstract: http://bjsm.bmj.com/content/early/2016/09/20/bjsports-2016-096224.abstract CONSULTATION: Hypophosphatasia (paediatric-onset) - asfotase alfa [ID758]: Second evaluation consultation The Department of Health has asked the National Institute for Health and Care Excellence (NICE) to produce guidance on using asfotase alfa in the context of national commissioning by NHS England. This document has been prepared for consultation with the consultees. It summarises the evidence and views that have been considered, and sets out the draft recommendations made by the committee. Consultation: https://www.nice.org.uk/guidance/indevelopment/gid-hypophosphatasiaasfotasealfaid758/consultation/html-content-2 News: https://www.nice.org.uk/news/article/nice-to-recommend-new-drug-to-treat-rare-inherited-bone-disorder-in-children

COMMISSIONING CONSULTATION: Hypophosphatasia (paediatric-onset) - asfotase alfa [ID758]: Second evaluation consultation The Department of Health has asked the National Institute for Health and Care Excellence (NICE) to produce guidance on using asfotase alfa in the context of national commissioning by NHS England. This document has been prepared for consultation with the consultees. It summarises the evidence and views that have been considered, and sets out the draft recommendations made by the committee. Consultation: https://www.nice.org.uk/guidance/indevelopment/gid-hypophosphatasiaasfotasealfaid758/consultation/html-content-2 News: https://www.nice.org.uk/news/article/nice-to-recommend-new-drug-to-treat-rare-inherited-bone-disorder-in-children CCG Outcomes Indicator Set - September 2016 The indicators aim to provide clear, comparative information for Clinical Commissioning Groups (CCGs) and Health and Wellbeing Boards (HWBs) about the quality of health services commissioned by CCGs and, as far as possible, the associated health outcomes.

Statistics: http://www.digital.nhs.uk/catalogue/PUB21732 NHS Operational Planning and Contracting Guidance 2017-2019 NHS England and NHS Improvement have published this year’s operational and contracting planning guidance three months earlier than normal to help local organisations plan more strategically. For the first time, the planning guidance covers two financial years, to provide greater stability and support transformation. Guidance: https://www.england.nhs.uk/wp-content/uploads/2016/09/NHS-operational-planning-guidance-201617-201819.pdf Associated documents: https://www.england.nhs.uk/ourwork/futurenhs/deliver-forward-view/ News: https://www.england.nhs.uk/2016/09/next-steps-fyfv/ Related news: https://www.england.nhs.uk/2016/09/improve-mental-healthcare/ Planning guidance 2017-19 responses Responses to the recently NHS England and NHS Improvement published guidance. NHS Confederation: http://www.nhsconfed.org/media-centre/2016/09/response-to-planning-guidance-2017-to-2019 Royal College of General Practitioners: http://www.rcgp.org.uk/news/2016/september/rcgp-response-to-new-planning-guidance-from-nhs-england.aspx Nuffield Trust: http://www.nuffieldtrust.org.uk/media-centre/press-releases/our-response-nhs-planning-guidance CASE STUDIES: Safe sustainable and productive staffing A collection of staffing and workforce case studies providing examples of best practice and innovation improvement from NHS providers and commissioners across a range of care settings. Case studies: https://improvement.nhs.uk/resources/safe-sustainable-and-productive-staffing-case-studies/ Proposed national tariff prices: planning for 2017/18 and 2018/19 NHS Improvement have published proposed national tariff prices for 2017/18 and 2018/19 to help NHS providers and commissioners with the planning process. The prices have been developed since the August engagement event and include the efficiency factor. Guidance: https://improvement.nhs.uk/resources/proposed-national-tariff-prices-1718-1819/ Further information: https://improvement.nhs.uk/resources/developing-201718-national-tariff/ Syndromic surveillance summary: 15th September 2016 week 36 This weekly summary highlights changes in the number of people visiting GPs, going to emergency departments, and calling NHS 111. It will help GPs and other public health professionals identify trends and prepare for public health threats, like high levels of flu or heat-related illnesses. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554837/PHESyndromicSurveillanceSummary2016Week37.pdf Previous bulletins: https://www.gov.uk/government/publications/syndromic-surveillance-summary Emergency department bulletin: 15th September 2016 week 36 The Emergency Department Syndromic Surveillance System (EDSSS) monitors the patient attendances each day, and what symptoms patients have, in a network of emergency departments across England and Northern Ireland. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554842/EDSSSBulletin2016wk37.pdf Previous bulletins: https://www.gov.uk/government/publications/emergency-department-bulletin Remote health advice: 15th September 2016 week 36 Monitoring patterns in phone calls to the NHS 111 service each day across England, to track the spread of infectious diseases like flu and norovirus. These data provide early warning of community-based infectious diseases. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554838/PHE_Remote_Health_Advice_Weekly_Bulletin_2016_Week_37.pdf Previous bulletins: https://www.gov.uk/government/publications/remote-health-advice-bulletin

GP out-of-hours consultations bulletin: 15th September 2016 week 36 Monitoring the number of people contacting their GPs outside of surgery hours. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554841/GPOOHSSEngBulletin2016Wk37.pdf Previous bulletins: https://www.gov.uk/government/publications/gp-out-of-hours-syndromic-surveillance-bulletin GP in-hours consultations bulletin: 15th September 2016 week 36 Monitoring the number of visits to GPs during regular surgery hours for important clinical indicators. This system reports daily, and covers over 55% of England’s population. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554839/GPinHoursEngBulletin2016Wk37.pdf Previous bulletins: https://www.gov.uk/government/publications/gp-in-hours-bulletin NHS Diabetic Eye Screening Programme: Management of patients not included on the screening register Each local diabetic eye screening service is required to have a single collated list (SCL) of all people in the local population who are eligible for screening. This guidance is to help commissioners and provider organisations manage incidents related to the SCL, including newly identified diabetic patients who were previously unknown to the screening service and should now be included on the list. Guidance: https://www.gov.uk/government/publications/diabetic-eye-screening-managing-patients-not-on-screening-register Leeds’ progress as an integrated care pioneer Blog from: Councillor Rebecca Charlwood, Chair, Leeds Health and Wellbeing Board and Executive Member for Health, Wellbeing and Adults for Leeds City Council. Blog: https://www.england.nhs.uk/2016/09/rebecca-charlwood/ EVENT: Long Term Conditions Conference 2017 This conference, now in its seventh year will see commissioners, GPs, primary and secondary care givers, nurses, community practitioners and 3rd sector volunteers exploring policies, strategies, case studies and best practice used across the sector to tackle long term conditions and enable patients to live an independent lifestyle with a greater quality of life. Further information: http://ltc-conference.co.uk/ EVENT: Managing Change: Transformation for Productive Public Services This conference will focus on positive and practical solutions in bringing about change and will serve as an opportunity to share innovative best practice that is delivering the desired results. The plenary sessions will showcase a number of transformational projects that have adopted a variety of principles, methodologies and tools to implement change and enhance public services. Further information: http://www.openforumevents.co.uk/event/managing-change-transformation-more-productive-public-services/ Vital Directions for Health and Health Care The National Academy of Medicine called on more than 100 leading researchers, scientists, and policy makers from across the United States to provide expert guidance on 19 priority focus areas for U.S. health policy. The views are presented in this discussion paper series. Document: https://nam.edu/initiatives/vital-directions-for-health-and-health-care/vital-directions-for-health-health-care-discussion-papers/ AUDIO: WIHI: What's Next for Electronic Health Records What do we want from electronic health records? Well, it all depends on who you ask. The IHI Leadership Alliance has spent the past year learning about the discontent with EHRs and has compiled a series of observations and recommendations in hopes of instigating important changes. Guests discuss what changes are possible and likely in the near term. NB: Free registration may be needed to access the associated documents. Audio (60 minutes): http://www.ihi.org/resources/Pages/AudioandVideo/WIHI-Whats-Next-For-Electronic-Health-Records-EHR.aspx

DIABETES NHS Diabetic Eye Screening Programme: Management of patients not included on the screening register Each local diabetic eye screening service is required to have a single collated list (SCL) of all people in the local population who are eligible for screening. This guidance is to help commissioners and provider organisations manage incidents related to the SCL, including newly identified diabetic patients who were previously unknown to the screening service and should now be included on the list. Guidance: https://www.gov.uk/government/publications/diabetic-eye-screening-managing-patients-not-on-screening-register TI Resources This website was designed as a useful starting point for anyone wanting to begin to explore social media and online information to help them manage type 1 diabetes. It is a one-stop shop of T1 resources sourced from the internet in various formats to suit the needs of a diverse audience. The resources are co-curated with peer-review (people living with type 1 diabetes, parents and carers) and healthcare professional quality assurance. Resource: https://www.t1resources.uk/home/

DIAGNOSTICS AltaBioscience announces UKAS accreditation of new 'hormone fingerprint' test: application as an aid to diagnosis of adrenal cancer A new analytical test has been launched in the UK that provides sensitive, specific and efficient predictive analysis of a rare form of cancer from a simple urine sample. The steroid profiling test is expected to improve diagnosis for adrenocortical carcinoma (ACC). News: http://www.birmingham.ac.uk/news/latest/2016/09/altabioscience-announces-application-aid-diagnosis-of-adrenal-cancer.aspx

EMERGENCY MEDICINE/CRITICAL CARE Syndromic surveillance summary: 15th September 2016 week 36 This weekly summary highlights changes in the number of people visiting GPs, going to emergency departments, and calling NHS 111. It will help GPs and other public health professionals identify trends and prepare for public health threats, like high levels of flu or heat-related illnesses. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554837/PHESyndromicSurveillanceSummary2016Week37.pdf Previous bulletins: https://www.gov.uk/government/publications/syndromic-surveillance-summary Emergency department bulletin: 15th September 2016 week 36 The Emergency Department Syndromic Surveillance System (EDSSS) monitors the patient attendances each day, and what symptoms patients have, in a network of emergency departments across England and Northern Ireland. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554842/EDSSSBulletin2016wk37.pdf Previous bulletins: https://www.gov.uk/government/publications/emergency-department-bulletin

GASTROENTEROLOGY CONSULTATION: Hepatitis C (chronic) - sofosbuvir and velpatasvir [ID921]: Appraisal consultation This document summarises the evidence and views that have been considered, and sets out the recommendations made by the National Institute for Health and Care Excellence (NICE) Appraisal Committee. Consultation: https://www.nice.org.uk/guidance/indevelopment/gid-ta10064/consultation/html-content

GENERAL MEDICINE Sleep is key to curing chronic pain A link between chronic pain and lack of sleep has been identified by a team of researchers. They also discovered that people with pain who believe they won't be able to sleep are more likely to suffer from insomnia, thus causing worse pain. A pioneering study could lead to specific cognitive therapy to cure insomnia and treat chronic pain. News: https://www.sciencedaily.com/releases/2016/09/160921084808.htm Abstract: http://www.aasmnet.org/jcsm/ViewAbstract.aspx?pid=30784 CONSULTATION: Hypophosphatasia (paediatric-onset) - asfotase alfa [ID758]: Second evaluation consultation The Department of Health has asked the National Institute for Health and Care Excellence (NICE) to produce guidance on using asfotase alfa in the context of national commissioning by NHS England. This document has been prepared for consultation with the consultees. It summarises the evidence and views that have been considered, and sets out the draft recommendations made by the committee. Consultation: https://www.nice.org.uk/guidance/indevelopment/gid-hypophosphatasiaasfotasealfaid758/consultation/html-content-2 News: https://www.nice.org.uk/news/article/nice-to-recommend-new-drug-to-treat-rare-inherited-bone-disorder-in-children PACE trial shows why medicine needs patients to scrutinise studies about their health Blog from: Simon McGrath who had an all too brief career in charity fundraising before becoming too ill to work in 1995. He has a biochemistry degree from the University of Oxford and occasionally blogs about ME/CFS research. Blog: http://blogs.bmj.com/bmj/2016/09/22/simon-mcgrath-pace-trial-shows-why-medicine-needs-patients-to-scrutinise-studies-about-their-health/ Releasing patient data from the PACE trial for chronic fatigue syndrome Blog from: Peter White, Professor of Psychological Medicine, Queen Mary University of London, Co-Principal Investigator (Co-PI) of the PACE trial; Trudie Chalder, Professor of Cognitive Behavioural Psychotherapy, King’s College London, Co-Principal Investigator (Co-PI) of the PACE trial; and Michael Sharpe, Professor of Psychological Medicine, University of Oxford (previously at the University of Edinburgh), a consultant psychiatrist Co-Principal Investigator (Co-PI) of the PACE trial. Blog: http://blogs.bmj.com/bmj/2016/09/22/peter-white-et-al-releasing-patient-data-from-the-pace-trial-for-chronic-fatigue-syndrome/ EVENT: Public Health: Prevention in Practice This event is designed to consider the current public health challenges in the UK today and explore the policies and solutions to influence and improve the health of the nation. Further information: http://www.openforumevents.co.uk/event/public-health-prevention-practice/ Fear of stigma or sanction keeps many doctors from revealing mental health issues, study finds Even as doctors across America encourage their patients to share concerns about depression, anxiety and other concerns, a new study suggests the doctors may be less likely to seek help for those same concerns about themselves. News: https://www.sciencedaily.com/releases/2016/09/160922093402.htm Abstract: http://www.ghpjournal.com/article/S0163-8343(16)30128-1/abstract

GENERAL PRACTICE AND PRACTICE MANAGEMENT Sleep is key to curing chronic pain A link between chronic pain and lack of sleep has been identified by a team of researchers. They also discovered that people with pain who believe they won't be able to sleep are more likely to suffer from insomnia, thus causing worse pain. A pioneering study could lead to specific cognitive therapy to cure insomnia and treat chronic pain. News: https://www.sciencedaily.com/releases/2016/09/160921084808.htm Abstract: http://www.aasmnet.org/jcsm/ViewAbstract.aspx?pid=30784

NHS Immunisation Statistics, England - 2015-16 This publication reports childhood immunisation statistics for England in 2015-16, and relates to routine vaccinations offered to all children up to the age of 5 years. The statistics show the number of children vaccinated as a proportion of the eligible population (coverage), and are derived from information collected by Public Health England (PHE) through the Cover of Vaccination Evaluated Rapidly (COVER) and Seasonal Influenza programmes. Statistics: http://www.digital.nhs.uk/catalogue/PUB21651/nhs-imms-stat-eng-2015-16-rep.pdf News: http://digital.nhs.uk/article/7408/Annual-childhood-immunisation-statistics-published Syndromic surveillance summary: 15th September 2016 week 36 This weekly summary highlights changes in the number of people visiting GPs, going to emergency departments, and calling NHS 111. It will help GPs and other public health professionals identify trends and prepare for public health threats, like high levels of flu or heat-related illnesses. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554837/PHESyndromicSurveillanceSummary2016Week37.pdf Previous bulletins: https://www.gov.uk/government/publications/syndromic-surveillance-summary Remote health advice: 15th September 2016 week 36 Monitoring patterns in phone calls to the NHS 111 service each day across England, to track the spread of infectious diseases like flu and norovirus. These data provide early warning of community-based infectious diseases. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554838/PHE_Remote_Health_Advice_Weekly_Bulletin_2016_Week_37.pdf Previous bulletins: https://www.gov.uk/government/publications/remote-health-advice-bulletin GP out-of-hours consultations bulletin: 15th September 2016 week 36 Monitoring the number of people contacting their GPs outside of surgery hours. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554841/GPOOHSSEngBulletin2016Wk37.pdf Previous bulletins: https://www.gov.uk/government/publications/gp-out-of-hours-syndromic-surveillance-bulletin GP in-hours consultations bulletin: 15th September 2016 week 36 Monitoring the number of visits to GPs during regular surgery hours for important clinical indicators. This system reports daily, and covers over 55% of England’s population. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554839/GPinHoursEngBulletin2016Wk37.pdf Previous bulletins: https://www.gov.uk/government/publications/gp-in-hours-bulletin Leeds’ progress as an integrated care pioneer Blog from: Councillor Rebecca Charlwood, Chair, Leeds Health and Wellbeing Board and Executive Member for Health, Wellbeing and Adults for Leeds City Council. Blog: https://www.england.nhs.uk/2016/09/rebecca-charlwood/ Next steps for improving general practice services outlined by NHS England and NHS Improvement Planning guidance issued today gives more details on how the extra funding announced in the General Practice Forward View will be used to help transform services. News: https://www.england.nhs.uk/2016/09/improving-general-practice/ Associated documents: https://www.england.nhs.uk/2016/09/next-steps-fyfv/ Planning guidance 2017-19 responses Responses to the recently NHS England and NHS Improvement published guidance. NHS Confederation: http://www.nhsconfed.org/media-centre/2016/09/response-to-planning-guidance-2017-to-2019 Royal College of General Practitioners: http://www.rcgp.org.uk/news/2016/september/rcgp-response-to-new-planning-guidance-from-nhs-england.aspx Nuffield Trust: http://www.nuffieldtrust.org.uk/media-centre/press-releases/our-response-nhs-planning-guidance

PACE trial shows why medicine needs patients to scrutinise studies about their health Blog from: Simon McGrath who had an all too brief career in charity fundraising before becoming too ill to work in 1995. He has a biochemistry degree from the University of Oxford and occasionally blogs about ME/CFS research. Blog: http://blogs.bmj.com/bmj/2016/09/22/simon-mcgrath-pace-trial-shows-why-medicine-needs-patients-to-scrutinise-studies-about-their-health/ Releasing patient data from the PACE trial for chronic fatigue syndrome Blog from: Peter White, Professor of Psychological Medicine, Queen Mary University of London, Co-Principal Investigator (Co-PI) of the PACE trial; Trudie Chalder, Professor of Cognitive Behavioural Psychotherapy, King’s College London, Co-Principal Investigator (Co-PI) of the PACE trial; and Michael Sharpe, Professor of Psychological Medicine, University of Oxford (previously at the University of Edinburgh), a consultant psychiatrist Co-Principal Investigator (Co-PI) of the PACE trial. Blog: http://blogs.bmj.com/bmj/2016/09/22/peter-white-et-al-releasing-patient-data-from-the-pace-trial-for-chronic-fatigue-syndrome/ EVENT: Long Term Conditions Conference 2017 This conference, now in its seventh year will see commissioners, GPs, primary and secondary care givers, nurses, community practitioners and 3rd sector volunteers exploring policies, strategies, case studies and best practice used across the sector to tackle long term conditions and enable patients to live an independent lifestyle with a greater quality of life. Further information: http://ltc-conference.co.uk/ Ophthalmic Special Order Products: August 2016 The Royal College of Ophthalmologists and the UK Ophthalmic Pharmacy Group have issued updated guidance on the safety and value of certain unlicensed ophthalmic preparations prescribed and dispensed in primary care and to assist general practitioners in making decisions about these products. Guidance: https://www.rcophth.ac.uk/2016/09/ophthalmic-special-order-products-august-2016-update/ Superbugs: real problem, real work Blog from Sarah Chapman, Knowledge Broker, Cochrane UK. Blog: http://www.evidentlycochrane.net/superbugs-real-problem-real-work/ TI Resources This website was designed as a useful starting point for anyone wanting to begin to explore social media and online information to help them manage type 1 diabetes. It is a one-stop shop of T1 resources sourced from the internet in various formats to suit the needs of a diverse audience. The resources are co-curated with peer-review (people living with type 1 diabetes, parents and carers) and healthcare professional quality assurance. Resource: https://www.t1resources.uk/home/

EVENT: Public Health: Prevention in Practice This event is designed to consider the current public health challenges in the UK today and explore the policies and solutions to influence and improve the health of the nation. Further information: http://www.openforumevents.co.uk/event/public-health-prevention-practice/ AUDIO: WIHI: What's Next for Electronic Health Records What do we want from electronic health records? Well, it all depends on who you ask. The IHI Leadership Alliance has spent the past year learning about the discontent with EHRs and has compiled a series of observations and recommendations in hopes of instigating important changes. Guests discuss what changes are possible and likely in the near term. NB: Free registration may be needed to access the associated documents. Audio (60 minutes): http://www.ihi.org/resources/Pages/AudioandVideo/WIHI-Whats-Next-For-Electronic-Health-Records-EHR.aspx Testing Ecopipam's effectiveness in treating stuttering Stuttering affects about three million Americans. Currently, no Food and Drug Administration (FDA)-approved drug treatments are available. In an attempt to find a new medicine, a research team will conduct a study to determine how effective ecopipam, an orally administered medication, is as treatment against stuttering.

News: https://www.sciencedaily.com/releases/2016/09/160922085741.htm Fear of stigma or sanction keeps many doctors from revealing mental health issues, study finds Even as doctors across America encourage their patients to share concerns about depression, anxiety and other concerns, a new study suggests the doctors may be less likely to seek help for those same concerns about themselves. News: https://www.sciencedaily.com/releases/2016/09/160922093402.htm Abstract: http://www.ghpjournal.com/article/S0163-8343(16)30128-1/abstract

HEALTH SERVICES MANAGEMENT CONSULTATION: Smoking cessation interventions and services: Call for Evidence The National Institute for Health and Care Excellence (NICE) have issued a call for evidence for this guidance which they are developing. They are particularly interested in information promoting equality of opportunity relating to age, disability, gender, gender identity, ethnicity, religion and belief, sexual orientation or socio-economic status. Consultation: https://www.nice.org.uk/guidance/indevelopment/gid-phg94/consultation/html-content-2 Summary Hospital-level Mortality Indicator (SHMI) - Deaths associated with hospitalisation, England, April 2015 - March 2016 The Summary Hospital-level Mortality Indicator (SHMI) is the ratio between the actual number of patients who die following hospitalisation at the trust and the number that would be expected to die on the basis of average England figures, given the characteristics of the patients treated there. This publication of the SHMI relates to discharges in the reporting period April 2015 to March 2016. Statistics: http://www.digital.nhs.uk/catalogue/PUB21665 Inspiring improvement newsletter – September 2016 Latest roundup of improvement work and innovation from across the NHS. Newsletter: http://dmtrk.net/t/2J9J-WFOB-742FFPCN3D/cr.aspx?v=0 NHS Operational Planning and Contracting Guidance 2017-2019 NHS England and NHS Improvement have published this year’s operational and contracting planning guidance three months earlier than normal to help local organisations plan more strategically. For the first time, the planning guidance covers two financial years, to provide greater stability and support transformation. Guidance: https://www.england.nhs.uk/wp-content/uploads/2016/09/NHS-operational-planning-guidance-201617-201819.pdf Associated documents: https://www.england.nhs.uk/ourwork/futurenhs/deliver-forward-view/ News: https://www.england.nhs.uk/2016/09/next-steps-fyfv/ Related news: https://www.england.nhs.uk/2016/09/improve-mental-healthcare/ Planning guidance 2017-19 responses Responses to the recently NHS England and NHS Improvement published guidance. NHS Confederation: http://www.nhsconfed.org/media-centre/2016/09/response-to-planning-guidance-2017-to-2019 Royal College of General Practitioners: http://www.rcgp.org.uk/news/2016/september/rcgp-response-to-new-planning-guidance-from-nhs-england.aspx Nuffield Trust: http://www.nuffieldtrust.org.uk/media-centre/press-releases/our-response-nhs-planning-guidance Shared planning guidance: for NHS trusts and foundation trusts (Updated) NHS Improvement have replaced Annex 5 with Annex F: NHS Improvement guidance for operational and activity plans. Links to Operational planning and contracting guidance 2017/18 and 2018/19 and Technical guidance for NHS planning 2017/18 and 2018/19 which are both hosted by NHS England have also been included. Guidance: https://improvement.nhs.uk/resources/nhs-shared-planning-guidance/ CASE STUDIES: Safe sustainable and productive staffing A collection of staffing and workforce case studies providing examples of best practice and innovation improvement from NHS providers and commissioners across a range of care settings.

Case studies: https://improvement.nhs.uk/resources/safe-sustainable-and-productive-staffing-case-studies/ Proposed national tariff prices: planning for 2017/18 and 2018/19 NHS Improvement have published proposed national tariff prices for 2017/18 and 2018/19 to help NHS providers and commissioners with the planning process. The prices have been developed since the August engagement event and include the efficiency factor. Guidance: https://improvement.nhs.uk/resources/proposed-national-tariff-prices-1718-1819/ Further information: https://improvement.nhs.uk/resources/developing-201718-national-tariff/ Syndromic surveillance summary: 15th September 2016 week 36 This weekly summary highlights changes in the number of people visiting GPs, going to emergency departments, and calling NHS 111. It will help GPs and other public health professionals identify trends and prepare for public health threats, like high levels of flu or heat-related illnesses. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554837/PHESyndromicSurveillanceSummary2016Week37.pdf Previous bulletins: https://www.gov.uk/government/publications/syndromic-surveillance-summary Emergency department bulletin: 15th September 2016 week 36 The Emergency Department Syndromic Surveillance System (EDSSS) monitors the patient attendances each day, and what symptoms patients have, in a network of emergency departments across England and Northern Ireland. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554842/EDSSSBulletin2016wk37.pdf Previous bulletins: https://www.gov.uk/government/publications/emergency-department-bulletin Remote health advice: 15th September 2016 week 36 Monitoring patterns in phone calls to the NHS 111 service each day across England, to track the spread of infectious diseases like flu and norovirus. These data provide early warning of community-based infectious diseases. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554838/PHE_Remote_Health_Advice_Weekly_Bulletin_2016_Week_37.pdf Previous bulletins: https://www.gov.uk/government/publications/remote-health-advice-bulletin NHS Diabetic Eye Screening Programme: Management of patients not included on the screening register Each local diabetic eye screening service is required to have a single collated list (SCL) of all people in the local population who are eligible for screening. This guidance is to help commissioners and provider organisations manage incidents related to the SCL, including newly identified diabetic patients who were previously unknown to the screening service and should now be included on the list. Guidance: https://www.gov.uk/government/publications/diabetic-eye-screening-managing-patients-not-on-screening-register Nurses have a key role to play in supporting people with Parkinson’s Blog from: Jacqueline Young, Parkinson’s Specialist Nurse, Cambridge. Blog: https://www.england.nhs.uk/2016/09/jacqueline-young/ Leeds’ progress as an integrated care pioneer Blog from: Councillor Rebecca Charlwood, Chair, Leeds Health and Wellbeing Board and Executive Member for Health, Wellbeing and Adults for Leeds City Council. Blog: https://www.england.nhs.uk/2016/09/rebecca-charlwood/ EVENT: Long Term Conditions Conference 2017 This conference, now in its seventh year will see commissioners, GPs, primary and secondary care givers, nurses, community practitioners and 3rd sector volunteers exploring policies, strategies, case studies and best practice used across the sector to tackle long term conditions and enable patients to live an independent lifestyle with a greater quality of life. Further information: http://ltc-conference.co.uk/

EVENT: Managing Change: Transformation for Productive Public Services This conference will focus on positive and practical solutions in bringing about change and will serve as an opportunity to share innovative best practice that is delivering the desired results. The plenary sessions will showcase a number of transformational projects that have adopted a variety of principles, methodologies and tools to implement change and enhance public services. Further information: http://www.openforumevents.co.uk/event/managing-change-transformation-more-productive-public-services/ EVENT: Public Health: Prevention in Practice This event is designed to consider the current public health challenges in the UK today and explore the policies and solutions to influence and improve the health of the nation. Further information: http://www.openforumevents.co.uk/event/public-health-prevention-practice/ NHS Workforce Bulletin Issue 535, 19 September 2016 Tips, tools, guidance and information on NHS workforce issues from NHS Employers Bulletin: http://www.nhsemployers.org/?sc_itemid={6864AB22-2A26-4A39-BE23-0C46008A2586}&sc_lang=en&sc_pd_view=1&ec_as=BFB7FAF59B834BD0B337D83E363B9908 Vital Directions for Health and Health Care The National Academy of Medicine called on more than 100 leading researchers, scientists, and policy makers from across the United States to provide expert guidance on 19 priority focus areas for U.S. health policy. The views are presented in this discussion paper series. Document: https://nam.edu/initiatives/vital-directions-for-health-and-health-care/vital-directions-for-health-health-care-discussion-papers/ AUDIO: WIHI: What's Next for Electronic Health Records What do we want from electronic health records? Well, it all depends on who you ask. The IHI Leadership Alliance has spent the past year learning about the discontent with EHRs and has compiled a series of observations and recommendations in hopes of instigating important changes. Guests discuss what changes are possible and likely in the near term. NB: Free registration may be needed to access the associated documents. Audio (60 minutes): http://www.ihi.org/resources/Pages/AudioandVideo/WIHI-Whats-Next-For-Electronic-Health-Records-EHR.aspx Fear of stigma or sanction keeps many doctors from revealing mental health issues, study finds Even as doctors across America encourage their patients to share concerns about depression, anxiety and other concerns, a new study suggests the doctors may be less likely to seek help for those same concerns about themselves. News: https://www.sciencedaily.com/releases/2016/09/160922093402.htm Abstract: http://www.ghpjournal.com/article/S0163-8343(16)30128-1/abstract

IMMUNISATION NHS Immunisation Statistics, England - 2015-16 This publication reports childhood immunisation statistics for England in 2015-16, and relates to routine vaccinations offered to all children up to the age of 5 years. The statistics show the number of children vaccinated as a proportion of the eligible population (coverage), and are derived from information collected by Public Health England (PHE) through the Cover of Vaccination Evaluated Rapidly (COVER) and Seasonal Influenza programmes. Statistics: http://www.digital.nhs.uk/catalogue/PUB21651/nhs-imms-stat-eng-2015-16-rep.pdf News: http://digital.nhs.uk/article/7408/Annual-childhood-immunisation-statistics-published Syndromic surveillance summary: 15th September 2016 week 36 This weekly summary highlights changes in the number of people visiting GPs, going to emergency departments, and calling NHS 111. It will help GPs and other public health professionals identify trends and prepare for public health threats, like high levels of flu or heat-related illnesses. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554837/PHESyndromicSurveillanceSummary2016Week37.pdf Previous bulletins: https://www.gov.uk/government/publications/syndromic-surveillance-summary

Remote health advice: 15th September 2016 week 36 Monitoring patterns in phone calls to the NHS 111 service each day across England, to track the spread of infectious diseases like flu and norovirus. These data provide early warning of community-based infectious diseases. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554838/PHE_Remote_Health_Advice_Weekly_Bulletin_2016_Week_37.pdf Previous bulletins: https://www.gov.uk/government/publications/remote-health-advice-bulletin Use of unlicensed BCG vaccine to protect against tuberculosis (TB): information for healthcare professionals and prescribers (Updated) This guidance has been updated to include information for pregnant health care workers reconstituting the vaccine. Guidance: https://www.gov.uk/government/publications/intervax-bcg-vaccine-training-slideset-for-healthcare-professionals National rotavirus immunisation programme update: preliminary vaccine coverage for England, February 2016 to July 2016 This report describes rotavirus vaccine coverage data for the period February 2016 to July 2016, updating previous data reported for the period August 2015 to January 2016. Latest report: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/555048/hpr3216_rtvrs_VC.pdf Previous reports: https://www.gov.uk/government/publications/rotavirus-immunisation-programme-vaccine-coverage-estimates

INFECTION CONTROL AND INFECTIOUS DISEASES CONSULTATION: Hepatitis C (chronic) - sofosbuvir and velpatasvir [ID921]: Appraisal consultation This document summarises the evidence and views that have been considered, and sets out the recommendations made by the National Institute for Health and Care Excellence (NICE) Appraisal Committee. Consultation: https://www.nice.org.uk/guidance/indevelopment/gid-ta10064/consultation/html-content Superbugs: real problem, real work Blog from Sarah Chapman, Knowledge Broker, Cochrane UK. Blog: http://www.evidentlycochrane.net/superbugs-real-problem-real-work/ Computers learn to spot deadly bacteria Machine learning can predict strains of bacteria likely to cause food poisoning outbreaks, research has found. The study - which focused on harmful strains of E. coli bacteria - could help public health officials to target interventions and reduce risk to human health. News: https://www.sciencedaily.com/releases/2016/09/160921163340.htm Abstract: http://www.pnas.org/content/early/2016/09/15/1606567113.abstract Full text article (PDF): http://www.pnas.org/content/early/2016/09/15/1606567113.full.pdf?with-ds=yes

INFORMATICS AND INFORMATION GOVERNANCE AUDIO: WIHI: What's Next for Electronic Health Records What do we want from electronic health records? Well, it all depends on who you ask. The IHI Leadership Alliance has spent the past year learning about the discontent with EHRs and has compiled a series of observations and recommendations in hopes of instigating important changes. Guests discuss what changes are possible and likely in the near term. NB: Free registration may be needed to access the associated documents. Audio (60 minutes): http://www.ihi.org/resources/Pages/AudioandVideo/WIHI-Whats-Next-For-Electronic-Health-Records-EHR.aspx

MATERNITY & GYNAECOLOGY Births by mothers' usual area of residence in the UK: 2015 Presents data on birth registrations in the UK by area of usual residence of mother. The tables contain summary data for live births for local authorities and local health boards (within Wales) including figures by age of mother. Data: http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/livebirths/datasets/birthsbyareaofusualresidenceofmotheruk

MEDICINES MANAGEMENT/PHARMACY CONSULTATION: Hypophosphatasia (paediatric-onset) - asfotase alfa [ID758]: Second evaluation consultation The Department of Health has asked the National Institute for Health and Care Excellence (NICE) to produce guidance on using asfotase alfa in the context of national commissioning by NHS England. This document has been prepared for consultation with the consultees. It summarises the evidence and views that have been considered, and sets out the draft recommendations made by the committee. Consultation: https://www.nice.org.uk/guidance/indevelopment/gid-hypophosphatasiaasfotasealfaid758/consultation/html-content-2 News: https://www.nice.org.uk/news/article/nice-to-recommend-new-drug-to-treat-rare-inherited-bone-disorder-in-children CONSULTATION: Hepatitis C (chronic) - sofosbuvir and velpatasvir [ID921]: Appraisal consultation This document summarises the evidence and views that have been considered, and sets out the recommendations made by the National Institute for Health and Care Excellence (NICE) Appraisal Committee. Consultation: https://www.nice.org.uk/guidance/indevelopment/gid-ta10064/consultation/html-content Ophthalmic Special Order Products: August 2016 The Royal College of Ophthalmologists and the UK Ophthalmic Pharmacy Group have issued updated guidance on the safety and value of certain unlicensed ophthalmic preparations prescribed and dispensed in primary care and to assist general practitioners in making decisions about these products. Guidance: https://www.rcophth.ac.uk/2016/09/ophthalmic-special-order-products-august-2016-update/ Superbugs: real problem, real work Blog from Sarah Chapman, Knowledge Broker, Cochrane UK. Blog: http://www.evidentlycochrane.net/superbugs-real-problem-real-work/

Testing Ecopipam's effectiveness in treating stuttering Stuttering affects about three million Americans. Currently, no Food and Drug Administration (FDA)-approved drug treatments are available. In an attempt to find a new medicine, a research team will conduct a study to determine how effective ecopipam, an orally administered medication, is as treatment against stuttering. News: https://www.sciencedaily.com/releases/2016/09/160922085741.htm

MENTAL HEALTH AND WELLBEING Sleep is key to curing chronic pain A link between chronic pain and lack of sleep has been identified by a team of researchers. They also discovered that people with pain who believe they won't be able to sleep are more likely to suffer from insomnia, thus causing worse pain. A pioneering study could lead to specific cognitive therapy to cure insomnia and treat chronic pain. News: https://www.sciencedaily.com/releases/2016/09/160921084808.htm Abstract: http://www.aasmnet.org/jcsm/ViewAbstract.aspx?pid=30784

Trial helps doctors tell Lewy body dementia from Alzheimer's, Parkinson's Knowing that many clinicians find it difficult to correctly diagnose patients with Lewy body dementia, researchers set out to develop a clinical profile for these patients. News: https://www.sciencedaily.com/releases/2016/09/160921151916.htm Full text article: http://content.iospress.com/articles/journal-of-alzheimers-disease/jad160384 Measuring national well-being in the UK, domains and measures: Sept 2016 An assessment of UK progress against a set of headline national well-being indicators which include our health, natural environment, personal finances and crime. Change over time is also assessed to establish whether national well-being is improving or deteriorating. Statistics: http://www.ons.gov.uk/releases/measuringnationalwellbeingintheukdomainsandmeasuressept2016 Fear of stigma or sanction keeps many doctors from revealing mental health issues, study finds Even as doctors across America encourage their patients to share concerns about depression, anxiety and other concerns, a new study suggests the doctors may be less likely to seek help for those same concerns about themselves. News: https://www.sciencedaily.com/releases/2016/09/160922093402.htm Abstract: http://www.ghpjournal.com/article/S0163-8343(16)30128-1/abstract

NEUROLOGY Trial helps doctors tell Lewy body dementia from Alzheimer's, Parkinson's Knowing that many clinicians find it difficult to correctly diagnose patients with Lewy body dementia, researchers set out to develop a clinical profile for these patients. News: https://www.sciencedaily.com/releases/2016/09/160921151916.htm Full text article: http://content.iospress.com/articles/journal-of-alzheimers-disease/jad160384 Nurses have a key role to play in supporting people with Parkinson’s Blog from: Jacqueline Young, Parkinson’s Specialist Nurse, Cambridge. Blog: https://www.england.nhs.uk/2016/09/jacqueline-young/

NURSING PRACTICE Nurses have a key role to play in supporting people with Parkinson’s Blog from: Jacqueline Young, Parkinson’s Specialist Nurse, Cambridge. Blog: https://www.england.nhs.uk/2016/09/jacqueline-young/ EVENT: Long Term Conditions Conference 2017 This conference, now in its seventh year will see commissioners, GPs, primary and secondary care givers, nurses, community practitioners and 3rd sector volunteers exploring policies, strategies, case studies and best practice used across the sector to tackle long term conditions and enable patients to live an independent lifestyle with a greater quality of life. Further information: http://ltc-conference.co.uk/ EVENT: Public Health: Prevention in Practice This event is designed to consider the current public health challenges in the UK today and explore the policies and solutions to influence and improve the health of the nation. Further information: http://www.openforumevents.co.uk/event/public-health-prevention-practice/

OPHTHALMOLOGY NHS Diabetic Eye Screening Programme: Management of patients not included on the screening register Each local diabetic eye screening service is required to have a single collated list (SCL) of all people in the local population who are eligible for screening. This guidance is to help commissioners and provider organisations manage incidents related to the SCL, including newly identified diabetic patients who were previously unknown to the screening service and should now be included on the list. Guidance: https://www.gov.uk/government/publications/diabetic-eye-screening-managing-patients-not-on-screening-register

Ophthalmic Special Order Products: August 2016 The Royal College of Ophthalmologists and the UK Ophthalmic Pharmacy Group have issued updated guidance on the safety and value of certain unlicensed ophthalmic preparations prescribed and dispensed in primary care and to assist general practitioners in making decisions about these products. Guidance: https://www.rcophth.ac.uk/2016/09/ophthalmic-special-order-products-august-2016-update/

PATHOLOGY Shedding light on the mutational landscape of the most common paediatric cancer A group of researchers from Columbia University, Rutgers University, and institutions in Europe and Japan have identified genomic alterations in paediatric relapsed acute lymphoblastic leukaemia (ALL) that cause both therapy resistance and improved clinical response to multi-agent chemotherapy treatment. News: https://www.sciencedaily.com/releases/2016/09/160921155653.htm Abstract: http://www.pnas.org/content/early/2016/09/20/1608420113.abstract New strategy identified for treating acute myeloid leukaemia (AML) A promising new approach to the treatment of AML has been discovered by a team of researchers. In their report, the investigators have identified a crucial dysfunction in blood cell development that underlies AML and show that inhibiting the action of a specific enzyme prompts the differentiation of leukemic cells, reducing their number and decreasing their ability to propagate the cancer. News: https://www.sciencedaily.com/releases/2016/09/160921155846.htm Abstract: http://www.cell.com/cell/abstract/S0092-8674(16)31154-0 Delaying motor neuron loss A potential treatment to delay motor neuron loss and symptoms has been discovered in the inevitably fatal motor neuron disease (MND). Researchers have reported that triheptanoin, a synthetic triglyceride oil, might help to address problems with energy metabolism associated with the neurodegenerative disease. News: https://www.sciencedaily.com/releases/2016/09/160921161223.htm Full text article: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161816 Superbugs: real problem, real work Blog from Sarah Chapman, Knowledge Broker, Cochrane UK. Blog: http://www.evidentlycochrane.net/superbugs-real-problem-real-work/ AltaBioscience announces UKAS accreditation of new 'hormone fingerprint' test: application as an aid to diagnosis of adrenal cancer A new analytical test has been launched in the UK that provides sensitive, specific and efficient predictive analysis of a rare form of cancer from a simple urine sample. The steroid profiling test is expected to improve diagnosis for adrenocortical carcinoma (ACC). News: http://www.birmingham.ac.uk/news/latest/2016/09/altabioscience-announces-application-aid-diagnosis-of-adrenal-cancer.aspx

PUBLIC HEALTH/HEALTH IMPROVEMENT Sitting for long periods of time is the cause of 4% of deaths worldwide The next time you wrap up your work day and realize you've been sitting in front of the computer for almost eight straight hours, maybe you won't feel so proud of yourself. A new study, conducted in 54 countries around the world, declares that 3.8% of all deaths are due to the fact that society spends more than three hours a day sitting down. News: https://www.sciencedaily.com/releases/2016/09/160921095237.htm Abstract: http://www.ajpmonline.org/article/S0749-3797(16)00048-9/abstract Full text article: http://www.ajpmonline.org/article/S0749-3797(16)00048-9/pdf 50-country comparison of child and youth fitness levels: Insightful look at population health An international research team studied the aerobic fitness levels of children and youth across 50 countries. The study involved analysing 20-meter shuttle data, also called the beep test, from 1.1

million kids aged 9 to 17 years old from 50 countries. The beep test is the most popular field-based test of aerobic fitness levels of children and youth. It is also standardized and commonly used around the world. Tanzania came top, the UK came 17th out of 50, the USA placed 47 out of 50 with Mexico being the least fit. NB: The full text is available by logging in with OpenAthens News: http://www.cheori.org/en/newsreleases?newsid=1407 Abstract: http://bjsm.bmj.com/content/early/2016/09/20/bjsports-2016-096224.abstract CONSULTATION: Smoking cessation interventions and services: Call for Evidence The National Institute for Health and Care Excellence (NICE) have issued a call for evidence for this guidance which they are developing. They are particularly interested in information promoting equality of opportunity relating to age, disability, gender, gender identity, ethnicity, religion and belief, sexual orientation or socio-economic status. Consultation: https://www.nice.org.uk/guidance/indevelopment/gid-phg94/consultation/html-content-2 NHS Immunisation Statistics, England - 2015-16 This publication reports childhood immunisation statistics for England in 2015-16, and relates to routine vaccinations offered to all children up to the age of 5 years. The statistics show the number of children vaccinated as a proportion of the eligible population (coverage), and are derived from information collected by Public Health England (PHE) through the Cover of Vaccination Evaluated Rapidly (COVER) and Seasonal Influenza programmes. Statistics: http://www.digital.nhs.uk/catalogue/PUB21651/nhs-imms-stat-eng-2015-16-rep.pdf News: http://digital.nhs.uk/article/7408/Annual-childhood-immunisation-statistics-published Syndromic surveillance summary: 15th September 2016 week 36 This weekly summary highlights changes in the number of people visiting GPs, going to emergency departments, and calling NHS 111. It will help GPs and other public health professionals identify trends and prepare for public health threats, like high levels of flu or heat-related illnesses. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554837/PHESyndromicSurveillanceSummary2016Week37.pdf Previous bulletins: https://www.gov.uk/government/publications/syndromic-surveillance-summary Remote health advice: 15th September 2016 week 36 Monitoring patterns in phone calls to the NHS 111 service each day across England, to track the spread of infectious diseases like flu and norovirus. These data provide early warning of community-based infectious diseases. Latest bulletin: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554838/PHE_Remote_Health_Advice_Weekly_Bulletin_2016_Week_37.pdf Previous bulletins: https://www.gov.uk/government/publications/remote-health-advice-bulletin Mental health promotion and prevention training programmes: Emerging practice examples This resource is a collation of emerging practice examples of mental health promotion and prevention training programmes available in England for the core and wider public health workforce. Its purpose is to support those who wish to commission or deliver such training as part of building a public health system capable of meeting the growing mental health challenge. Resource: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/554923/Mental_health_promotion_and_prevention_training_programmes.pdf Associated documents: https://www.gov.uk/government/publications/public-mental-health-leadership-and-workforce-development-framework NHS Diabetic Eye Screening Programme: Management of patients not included on the screening register Each local diabetic eye screening service is required to have a single collated list (SCL) of all people in the local population who are eligible for screening. This guidance is to help commissioners and provider organisations manage incidents related to the SCL, including newly identified diabetic patients who were previously unknown to the screening service and should now be included on the list. Guidance: https://www.gov.uk/government/publications/diabetic-eye-screening-managing-patients-not-on-screening-register

Use of unlicensed BCG vaccine to protect against tuberculosis (TB): information for healthcare professionals and prescribers (Updated) This guidance has been updated to include information for pregnant health care workers reconstituting the vaccine. Guidance: https://www.gov.uk/government/publications/intervax-bcg-vaccine-training-slideset-for-healthcare-professionals National rotavirus immunisation programme update: preliminary vaccine coverage for England, February 2016 to July 2016 This report describes rotavirus vaccine coverage data for the period February 2016 to July 2016, updating previous data reported for the period August 2015 to January 2016. Latest report: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/555048/hpr3216_rtvrs_VC.pdf Previous reports: https://www.gov.uk/government/publications/rotavirus-immunisation-programme-vaccine-coverage-estimates Smoking has a very broad, long-lasting impact on the human genome Smoking leaves its "footprint" on the human genome in the form of deoxyribonucleic acid (DNA) methylation, a process by which cells control gene activity, according to new research. Even after someone stops smoking, the effects of smoking remain in their DNA. News: https://www.sciencedaily.com/releases/2016/09/160921215106.htm Abstract: http://circgenetics.ahajournals.org/content/early/2016/09/14/CIRCGENETICS.116.001506.abstract Exercise for women receiving adjuvant therapy for breast cancer The authors of this review conclude that aerobic and resistance exercise can be regarded as beneficial for individuals with adjuvant therapy-related side effects. Further research is required to determine the optimal type, intensity, and timing of an exercise intervention. Cochrane review: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005001.pub3/full A look at the sexual health of young Londoners Blog from: Dr Yvonne Doyle, Regional Director of Public Health England (PHE) (London). Blog: https://publichealthmatters.blog.gov.uk/2016/09/22/a-look-at-the-sexual-health-of-young-londoners/ Measuring national well-being in the UK, domains and measures: Sept 2016 An assessment of UK progress against a set of headline national well-being indicators which include our health, natural environment, personal finances and crime. Change over time is also assessed to establish whether national well-being is improving or deteriorating. Statistics: http://www.ons.gov.uk/releases/measuringnationalwellbeingintheukdomainsandmeasuressept2016 Births by mothers' usual area of residence in the UK: 2015 Presents data on birth registrations in the UK by area of usual residence of mother. The tables contain summary data for live births for local authorities and local health boards (within Wales) including figures by age of mother. Data: http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/livebirths/datasets/birthsbyareaofusualresidenceofmotheruk Superbugs: real problem, real work Blog from Sarah Chapman, Knowledge Broker, Cochrane UK. Blog: http://www.evidentlycochrane.net/superbugs-real-problem-real-work/ TI Resources This website was designed as a useful starting point for anyone wanting to begin to explore social media and online information to help them manage type 1 diabetes. It is a one-stop shop of T1 resources sourced from the internet in various formats to suit the needs of a diverse audience. The resources are co-curated with peer-review (people living with type 1 diabetes, parents and carers) and healthcare professional quality assurance. Resource: https://www.t1resources.uk/home/

EVENT: Public Health: Prevention in Practice This event is designed to consider the current public health challenges in the UK today and explore the policies and solutions to influence and improve the health of the nation. Further information: http://www.openforumevents.co.uk/event/public-health-prevention-practice/ New Nutrition Labels Will Do Little to Bring Quality to American Diet Blog from: Deborah A. Cohen, Senior Natural Scientist, Rand Corporation. Blog: http://www.rand.org/blog/2016/08/new-nutrition-labels-will-do-little-to-bring-quality.html Computers learn to spot deadly bacteria Machine learning can predict strains of bacteria likely to cause food poisoning outbreaks, research has found. The study - which focused on harmful strains of E. coli bacteria - could help public health officials to target interventions and reduce risk to human health. News: https://www.sciencedaily.com/releases/2016/09/160921163340.htm Abstract: http://www.pnas.org/content/early/2016/09/15/1606567113.abstract Full text article (PDF): http://www.pnas.org/content/early/2016/09/15/1606567113.full.pdf?with-ds=yes

RESEARCH PACE trial shows why medicine needs patients to scrutinise studies about their health Blog from: Simon McGrath who had an all too brief career in charity fundraising before becoming too ill to work in 1995. He has a biochemistry degree from the University of Oxford and occasionally blogs about ME/CFS research. Blog: http://blogs.bmj.com/bmj/2016/09/22/simon-mcgrath-pace-trial-shows-why-medicine-needs-patients-to-scrutinise-studies-about-their-health/ Releasing patient data from the PACE trial for chronic fatigue syndrome Blog from: Peter White, Professor of Psychological Medicine, Queen Mary University of London, Co-Principal Investigator (Co-PI) of the PACE trial; Trudie Chalder, Professor of Cognitive Behavioural Psychotherapy, King’s College London, Co-Principal Investigator (Co-PI) of the PACE trial; and Michael Sharpe, Professor of Psychological Medicine, University of Oxford (previously at the University of Edinburgh), a consultant psychiatrist Co-Principal Investigator (Co-PI) of the PACE trial. Blog: http://blogs.bmj.com/bmj/2016/09/22/peter-white-et-al-releasing-patient-data-from-the-pace-trial-for-chronic-fatigue-syndrome/