Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

Keystone Symposia is pleased to present

Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction Scientific Organizers: Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia KralliApril 3–8, 2013 | Alpbach Congress Centrum | Alpbach, Austria

Plenary Session Topics: > Nuclear Receptors and Metabolism: Liver and Gut Pathways> Nuclear Receptors and Control of Food Intake> Nuclear Receptors and Energy Expenditure Pathways> Adipogenesis and Energy Storage> Lipid Metabolic Sensors> Immune System and Metabolism> Skeletal Muscle, Exercise and Diet> Circadian Clock and Metabolism

Abstract & Scholarship Deadline: December 4, 2012Late-Breaking Abstract Deadline: January 4, 2013Early Registration Deadline: January 31, 2013

Note: Scholarships are available to students and postdoctoral fellows and require a brief application and submission of an abstract. Short talk speakers will also be selected from abstracts. Early registration saves US$150 on later fee. Information shown is subject to possible change.

www.keystonesymposia.org/13D3

Keystone Symposia on Molecular and Cellular Biology is a nonprofit organization headquartered in Colorado, USA directed and supported by the scientific community.

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This meeting brings fundamental cellular and physiological principles involving nuclear receptors and other transcription factors to the boundaries between

physiology and disease-oriented research. As evidenced by the session titles, the organizers have developed a program that covers the involvement of nuclear receptors (NR) and other transcription factors (TFs) regulating energy balance (food intake, energy expenditure and fat deposition), and their pathophysiological dysregulation leading to obesity-associated cardio-metabolic complications. The program has been configured to bring together diverse, sometimes conflicting ideas, and novel approaches to investigate the involvement of NR and TFs that may help to elucidate them. A primary goal is to gather junior and senior investigators who study transcriptional mechanisms controlling different aspects of energy homeostasis and metabolic adaptation, and thereby stimulate new ideas as to how transcriptional networks could be targeted therapeutically in the context of metabolic disease. Taken together, the program design will provide an interdisciplinary integration of multiple organs and systems regulating energy homeostasis. Thus, this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact.

WEDNESDAY, APRIL 3Arrival and Registration

THURSDAY, APRIL 4Welcome and Keynote Address Antonio J. Vidal-Puig, University of Cambridge, UKWelcoming Remarks*Antonio Moschetta, Clinica Medica Frugoni, University of Bari, ItalyHelen H. Hobbs, University of Texas Southwestern Medical Center,USAABCG5/ABCG8: A Sterol Selectivity Filter for CholesterolHomeostasis

Nuclear Receptors and Metabolism: Liver and Gut Pathways *Michael Trauner, Medical University of Vienna, AustriaDavid D. Moore, Baylor College of Medicine, USANutrient Sensing Nuclear Receptors REgulat AutophagyDavid Shapiro, Intercept Pharmaceuticals, Inc., USAFXR Agonism – From Theory to PracticeAntonio Moschetta, Clinica Medica Frugoni, University of Bari, ItalyFXR in the Gut-Liver AxisMichela Plateroti, Université Claude Bernard Lyon 1, FranceThyroid Hormone Receptor and Intestinal Epithelium Stemness

Nuclear Receptors and Control of Food Intake *Beatrice Desvergne, University of Lausanne, SwitzerlandJoel K. Elmquist, University of Texas Southwestern Medical Center,USASF-1: A Molecular Link between Coordinated Energy Balance andMoodMiguel López, Universidad de Santiago de Compostela, SpainCentral Actions of Estrogens on Energy BalanceTony K.T. Lam, Toronto General Research Institute, CanadaCNS Action of Insulin and GlucagonBrian Finan, Novo Nordisk, USAShort Talk: Targeted Nuclear Hormone Delivery Using NaturalPeptides

Poster Session 1

FRIDAY, APRIL 5Nuclear Receptors and Energy Expenditure Pathways *Daniel P. Kelly, University of Pennsylvania, USAAnastasia Kralli, Johns Hopkins Medical School, USAEstrogen-Related Receptors (ERRs) and ERR Coregulators:Pathways Regulating Energy Expenditure in Brown Adipose TissueAntonio J. Vidal-Puig, University of Cambridge, UKBrown Fat Activity ModulatorsKrishna Chatterjee, University of Cambridge, UKNuclear Receptors and Metabolic Dysfunction: Insights from HumanGenetics

Beatrice Desvergne, University of Lausanne, SwitzerlandToo Much or Too Little Fat: Same Metabolic Consequences, SameMechanisms?Alessandra Ferrari, Università degli Studi di Milano, ItalyShort Talk: Key Role of Class I Histone Deacetylases in EnergyMetabolism via Regulation of Pgc-1alpha and PPARgammaJuliane G. Bogner-Strauss, Graz University of Technology, AustriaShort Talk: N-Acetyltransferase 8-Like: New Implications in BrownAdipocyte Metabolism through PPARalpha Signaling

Workshop and Round-Table Discussion: Targeting NRs for theTreatment of Metabolic Disease *Peter Tontonoz, University of California, Los Angeles, USAC. Daniel De Magalhaes Filho, The Salk Institute for BiologicalStudies, USAThe Effects of Overactivating a Fat Burning Pathway Upon SystemicAging and Age-Related Cardiac HealthDavid P. Marciano, Stanford University, USAModulating the PPARgamma Paradigm: Structural Insights into aNovel Class of Functional Selective LigandsKnut R. Steffensen, Karolinska Institute, SwedenThe Anti-inflammatory Roles of the Liver X Receptors in ColonConstance Maria Voss, University of Vienna, AustriaIdentification and Investigation of Novel LXR Modulators

Round-Table Discussion *David J. Mangelsdorf, University of Texas Southwestern MedicalCenter, USAKrishna Chatterjee, University of Cambridge, UKDavid Shapiro, Intercept Pharmaceuticals, Inc., USA

Adipogenesis and Energy Storage *Karen Reue, University of California, Los Angeles, USAEvan D. Rosen, Harvard University, USAEpigenomic Approaches to Target Identification in Adipose BiologyJuro Sakai, University of Tokyo, JapanEpigenomic Regulation of Energy Metabolism in Brown AdipocytesLluis Fajas, Université de Lausanne, SwitzerlandCell Cycle Regulators Control Energy HomeostasisAmit R. Majithia, University of California, San Diego, USAShort Talk: High Throughput Functional Analysis of Coding VariantsIdentified in Population Scale Genome Sequencing: A Paradigm forMapping Genes Underlying Human Metabolic DiseasesRalf Kittler, University of Texas Southwestern Medical Center, USAShort Talk: Pyruvate Dehydrogenase Kinase 4 Is a Key MetabolicRegulator of PPARgamma-Mediated Cell Cycle Arrest

Poster Session 2

SATURDAY, APRIL 6Nutrient Challenges and Lipid Homeostasis *Helen H. Hobbs, University of Texas Southwestern Medical Center,USA

* Session Chair † Invited but not yet accepted Program current as of November 9, 2021. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3)April 3-8, 2013 • Alpbach Congress Centrum • Alpbach, Austria

Scientific Organizers: Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia KralliSupported by the Directors' Fund

Discounted Abstract & Scholarship Deadline: December 4, 2012 / Late-Breaking Abstract Deadline: January 4, 2013 / Early Registration Deadline: January 31, 2013

David J. Mangelsdorf, University of Texas Southwestern MedicalCenter, USAA Survivor’s Guide to the Hunger Games: FGF21Peter Tontonoz, University of California, Los Angeles, USANuclear Receptor Regulation of Lipid Metabolism and InflammationRonald M. Evans, HHMI/The Salk Institute, USACatching Fire with FGF1: The Hunger Games SequelJaemyoung Suh, Korea Advanced Institute of Science &Technology, South KoreaCatching Fire with FGF1: The Hunger Games SequelKaren Reue, University of California, Los Angeles, USAReflections on Lipin Proteins, Lipid Storage, and Lipid IntermediatesFederica Gilardi, University of Lausanne, SwitzerlandShort Talk: Dynamics of SREBP1 DNA Binding in Mouse LiverPedro F. Marrero, University of Barcelona, SpainShort Talk: FSP27 Expression Regulates Liver PPARalpha SignalingActivity

Editors' Round-Table Randy S. Levinson, Cell Press, USAEffie Tzameli, Pfizer, USAEsther Schnapp, European Molecular Biology Organization, Germany

Workshop 2 *George E.O. Muscat, University of Queensland, AustraliaElnaz Karimian Azari, ETH-IFNH, SwitzerlandPossible Role of Intestinal Fatty Acid Oxidation (FAO) in thePeroxisome Proliferator Receptor-alpha (PPAR-alpha) AgonistWy-14643-Induced HypophagiaPooja Jha, Nature Metabolism; Nature Research, GermanyAdipose Triglyceride Lipase Critically Determines HepaticInflammation and Steatohepatitis via PPARalpha SignalingMichele Vacca, Consorzio Mario Negri Sud, ItalyNeuron-Derived Orphan Receptor 1 Acts as a Switch that AllowsProliferation in Quiescent HepatocytesCarmine Settembre, Telethon Foundation, ItalyTFEB Controls Cellular Lipid Metabolism through aStarvation-Induced Autoregulatory LoopKai Ge, NIDDK, National Institutes of Health, USAEpigenetic Regulation of Adipogenesis by Histone Methylation Andrea L. Hevener, University of California, Los Angeles, USASkeletal Muscle-Specific ERalpha Deficiency Impairs MitochondrialQuality Control and Promotes Features of the Metabolic SyndromeLily C. Chao, Children's Hospital Los Angeles, USANR4A1 Regulation of Fbp2 Promotes Muscle Growth

Immune System and Metabolism *Thomas P. Burris, Washington University School of Medicine, USAMercedes Ricote, Centro Nacional de InvestigacionesCardiovasculares, SpainEmerging Roles of RXRs in Macrophage Biology

Ajay Chawla, Merck Research Labs, USAType 2 Immunity at the Crossroads of Metabolism and RegenerationInez Rogatsky, Weill Medical College of Cornell University, USAAnti-Inflammatory Actions of Glucocorticoids: New Players andMechanismsEckardt Treuter, Karolinska Institutet, SwedenShort Talk: Dysregulation of a GPS2/SMRT Corepressor PathwayCoincides with Adipocyte Inflammation in Human Obesity

Poster Session 3

SUNDAY, APRIL 7Skeletal Muscle, Exercise and Diet *Andrea L. Hevener, University of California, Los Angeles, USADaniel P. Kelly, University of Pennsylvania, USANuclear Receptor-miRNA Regulatory NetworksJuleen R. Zierath, Karolinska Institutet, SwedenEpigenetic Regulation in Response to Exercise: Impact on Diabetesand ObesityVincent Giguère, McGill University, CanadamTOR: A New Friend of the Estrogen Related Receptor alphaCarl S. Thummel, University of Utah School of Medicine, USARegulation of Carbohydrate Metabolism by ERR and HNF4 inDrosophilaGeorge E.O. Muscat, University of Queensland, AustraliaShort Talk: Transgenic Nor-1/NR4A3 Expression DecreasesAdiposity: Resistance to (High Fat) Diet Induced Obesity in aBackground of Insulin ResistanceNoriaki Shimizu, , JapanShort Talk: Physiological Regulation of Skeletal Muscle Mass viaGlucocorticoid Receptor

Circadian Clock and Metabolism *Vincent Giguère, McGill University, CanadaPaolo Sassone-Corsi, University of California, Irvine, USAMetabolism Control of the Circadian ClockThomas P. Burris, Washington University School of Medicine, USAROR and REV-ERB Regulation of Immune Function and MetabolismKenneth A. Dyar, Venetian Institute of Molecular Medicine, ItalyShort Talk: The Skeletal Muscle Circadian Clock Controls InsulinSensitivity and Metabolic FlexibilityErin Stashi, Baylor College of Medicine, USAShort Talk: SRC-2 Is Essential for Orchestrating Circadian Rhythmand Metabolism

Closing Remarks Anastasia Kralli, Johns Hopkins Medical School, USA

MONDAY, APRIL 8Departure

* Session Chair † Invited but not yet accepted Program current as of November 9, 2021. Meal formats are based on meeting venue. For the most up-to-date details, visit https://www.keystonesymposia.org.

KEYSTONE SYMPOSIAon Molecular and Cellular Biology

Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction (D3)April 3-8, 2013 • Alpbach Congress Centrum • Alpbach, Austria

Scientific Organizers: Antonio J. Vidal-Puig, Antonio Moschetta and Anastasia KralliSupported by the Directors' Fund

Discounted Abstract & Scholarship Deadline: December 4, 2012 / Late-Breaking Abstract Deadline: January 4, 2013 / Early Registration Deadline: January 31, 2013