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JOURNAL OF CLINICAL MICROBIOLOGY, Jan. 2004 Copyright 2004, American Society for Microbiology




All submissions to the Journal of Clinical Microbiology(JCM) except modifications of manuscripts that werehandled in hard copy must be made electronically via theRapid Review online submission and peer review systemat the following URL: (E-mailed submissions will not beaccepted.) If the first version of the manuscript washandled in hard copy before online submission/reviewwas available, the modification must be sent in hardcopy, with an accompanying disk(s), to the editor.

The same guidelines previously used for hard-copymanuscripts still apply to manuscript source filepreparation, as follows. Type every portion of the manu-script double spaced (a minimum of 6 mm between lines),including figure legends, table footnotes, and References,and number all pages in sequence, including the abstract,figure legends, and tables. Place the last two items after theReferences section. Manuscript pages should have line num-bers. The font size should be no smaller than 12 pt. It isrecommended that the following sets of characters be eas-ily distinguishable in the manusript: the numeral zero (0)and the letter oh (O); the numeral one (1), the letter el(l), and the letter eye (I); and a multiplication sign ()and the letter ex (x). Do not create symbols as graphicsor use special fonts that are external to your word process-ing program; use the insert symbol function and selectcharacters from the normal text subset only. Set the pagesize to 812 by 11 inches. Italicize or underline any wordsthat should appear in italics. Include all section heads (seeOrganization and Format, p. vii), and indicate paragraphlead-ins in bold type. Because the electronic text file un-dergoes an automated preediting, cleanup, and taggingprocess specific to the particular article type before beingcopyedited (see Notification of Acceptance, below), it isimportant that it be formatted correctly with all the propersections and headings.

To submit a manuscript electronically, first create anAuthor account in the Rapid Review system, makingsure it contains a valid e-mail address. The same authoraccount may be used for all ASM journals. The personfrom whose account a submission is made will be re-corded as the corresponding author, and any correspon-dence will be sent to the e-mail address in their account.The same person must be indicated as the correspond-ing author on the manuscripts title page. Instructionsare provided throughout the submission process via on-line user notes, help menus, and submission guidelines.A help desk is also available.

Fill out the online submission form completely, even ifthe requested information is included on the manuscripttitle page. Do not put, e.g., See PDF in the Abstract

field because potential reviewers are not initially givenaccess to the entire manuscript and use the abstract onthe submission form to determine whether they are ableto do the review. If the manuscript is a resubmission,include the former ASM manuscript number and yearin the appropriate section of the form and supply point-by-point responses to the reviewers comments as a sup-plemental-data file (see Review Process on p. vi). Toexpedite the review process, authors should recommendat least two reviewers who are not members of theirinstitution(s) and have never been associated with themor their laboratory(ies); please provide their contact in-formation where indicated on the submission form.

Copies of in-press and submitted manuscripts that areimportant for judgment of the present manuscript shouldbe included as supplemental material to facilitate the re-view.

Authors who are unsure of proper English usageshould have their manuscripts checked by somone pro-ficient in the English language. Manuscripts may beeditorially rejected, before review, on the basis of poorEnglish or lack of conformity to the standards set forthin these instructions.

File Upload

Upload text and image files by following the on-screeninstructions. An automatic converter will create a singlePDF file from the source files submitted, assembling thevarious elements (text, figures, tables, etc.) in the orderspecified by the author. You must check the PDF con-version to complete the online submission. It is crucialthat you check the entire manuscript carefully, espe-cially the figures, to make sure that everything con-verted properly.

File Formats

Complete information on file types acceptable forelectronic submission is given in Rapid Review. Fileformats that are acceptable both for review purposesand, should the manuscript be accepted, for productioninclude those listed below. Less-stringent requirementsapply on initial submission of the manuscript if the au-thor specifies that the files are intended for reviewingpurposes only. Authors who choose to submit their en-tire manuscript as a ready-made PDF file, a format thatis acceptable for reviewing purposes only, must adjusttheir Adobe Acrobat settings to embed all fonts. Failureto do so may result in blank or illegible pages in themanuscript viewed by the editor and reviewers. Westrongly suggest that all files submitted, not just those formanuscripts at the modification stage, meet the criteriafor production.* Shading indicates material that has been added or updated.



Microsoft Word WordPerfect RTF


PDF* Word WordPerfect Word or WordPerfect with embedded Excel*

*Select reviewing purposes only for tables suppliedin these formats, even if you intend them to be used inproduction.


TIFF or EPS created from supported applications(see Illustrations and Tables on p. xii and visit for an up-to-date listingof supported applications)

PowerPoint (black-and-white figures only)

A feature called Rapid Inspector ( is available so that authors maycheck the acceptablitity of digital art for production anddetermine what must be fixed for the files to pass in-spection. See p. xiixiv for detailed instructions aboutillustrations.


Use of Microbiological Information

The Council Policy Committee (CPC) of the Ameri-can Society for Microbiology affirms the long-standingposition of the Society that microbiologists will work forthe proper and beneficent application of science and willcall to the attention of the public or the appropriateauthorities misuses of microbiology or of informationderived from microbiology. ASM members are obligatedto discourage any use of microbiology contrary to thewelfare of humankind, including the use of microbes asbiological weapons. Bioterrorism violates the fundamen-tal principles expressed in the Code of Ethics of theSociety and is abhorrent to the ASM and its members.

ASM recognizes that there are valid concerns regard-ing the publication of information in scientific journalsthat could be put to inappropriate use as described in theCPC resolution mentioned above. Members of the ASMPublications Board will evaluate the rare manuscriptthat might raise such issues during the review process.However, as indicated elsewhere in these Instructions,research articles must contain sufficient detail, and ma-terial/information must be made available, to permit thework to be repeated by others. Supply of materials

should be in accordance with laws and regulations gov-erning the shipment, transfer, possession, and use ofbiological materials and must be for legitimate, bona fideresearch needs. Links to, and information regarding,these laws and regulations can be found at

General Requirements

Manuscripts submitted to the journal must representreports of original research, and the original data mustbe available for review by the editor if necessary.

All authors of a manuscript must have agreed to itssubmission and are responsible for its content, includ-ing appropriate citations and acknowledgments, andmust also have agreed that the corresponding author hasthe authority to act on their behalf on all matters per-taining to publication of the manuscript. The corre-sponding author is responsible for obtaining such agree-ments and for informing the coauthors of themanuscripts status throughout the submission, review,and publication process. For Authors Corrections andRetractions, signed letters of agreement from all of theauthors must be submitted (see p. xixii).

By submission of a manuscript to the journal, theauthors guarantee that they have the authority to pub-lish the work and that the manuscript, or one withsubstantially the same content, was not published pre-viously, is not being considered or published elsewhere,and was not rejected on scientific grounds by anotherASM journal.

It is expected that the authors will provide writtenassurance that permission to cite unpublished data orpersonal communications has been granted.

By publishing in the journal, the authors agree thatany plasmids, viruses, and living materials such as mi-crobial strains and cell lines newly described in thearticle are available from a national collection or will bemade available in a timely fashion and at reasonablecost to members of the scientific community for non-commercial purposes.

Primary Publication

A scientific paper or its substance published in a serial,periodical, book, conference report, symposium pro-ceeding, or technical bulletin, posted on a nonpersonalwebsite, or made available through any other retrievablesource, including CD-ROM and other electronic forms,is unacceptable for submission to an ASM journa


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