jonathan urbina soto-comparaciÓn de la biodisponibilidad de Ácido acetilsalicÍlico entre el...

7/23/2019 JONATHAN URBINA SOTO-COMPARACIN DE LA BIODISPONIBILIDAD DE CIDO ACETILSALICLICO ENTRE EL CONSUMO DE AGUA Y REFRESCO DE COLA

1/28

HEOZGRGHN@ LK DG BNELNXZE@NBNDNLGL LK HNLEGHK\NDXGDNHDNHE K@\RK KD HE@X[OE LK GA[G ^

RKCRKXHE LK HEDG

N@\KARG@\KX=Grok`lgrnz Aunddk` Merak

Hruz \gvkrg Glrn`Fkr``lkz Zrkz Ogrne G`te`ne

Fkr``lkz Res \dgigkdkd GiedonztdnFkr``lkz Szqukz Aunddkroe \rn`nlgl

Rkyks Rgoes Ckr`g`le Nv`[rbn`g Xete Me`gtfg` [rnkd

Snhterng Murgle Gdle

[@NSKRXNLGL @GHNE@GD G[\@EOG LKOVNHE

GXKXER= WCB Gdkmg`lrk Rgze Nrog Xkokstrk 2:78/2


2/28

-

Xn``noes= GGX9 Gspnrn`g9 Ghnle e/Ghktexnbk`zenhe9 Ghktespnrn`g

Lkshrnphn`= Zkqukes hrnstgdkstrg`sdhnles$ n`hederes$prhtnhgok`tk nèleres

Zu`te lk cusn`= 782 / 786 H

Xedubndnlgl= K` gaug$ dnakrgok`tksedubdk k` ktgèd y tkr

H>F6E< 76:7; a%oed

Heonsn` Zkrog`k`tk lk dg Cgroghepkg lk des Kstgles [`nles Okxnhgès$ Cgroghepkg lk des Kstgles [`nles

Okxnhgès > Kl Oxnhe= Xkhrktgrng lk Xgdul$ Heonsn` Zkrog`k`tk lk dg Cgroghepkg lk des Kstgles [`nles

Okxnhgès$ 2::6


3/28

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CGROGHEDEANG

Kd hnle ghktndsgdnhdnhe ks u` croghe g`tnn`cdgogterne è kstkrenlke&GN@K. lk dg cgondng lk des sgdnhndgtes$ usgle crkhuk`tkok`tk k`=

Leder lk bgmg y oelkrglg n`tk`snlgl &hkcgdkg$ `kurgdang$ ongdang$grtrgdang y lnsokèrrkg.

Zrehkses n`cdgogternes &cnkbrk rkuotnhg$ grtrntns rkuogtenlk yestkegrtrntns.

Zrecndgxns lk k`ckroklglks gsehnglgs he` fnpkrgarkagbndnlglpdgquktgrng &grtkrnepgtg here`grng$ treobesns pesqunrranhg lkvk`gs precu`lgs.

Cnkbrk

Igtzuà Cgroghedeag bsnhg k` hd`nhg 6g Kl Klnterngd Kd Ogùgd Oelkrè$ Oxnhe$ 2::29 pp

>$


4/28

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ZREZNKLGLKX

Kd hnle ghktndsgdnhdnhe sk glon`nstrg usugdok`tk per vg ergd$gu`quk puklk skr glon`nstrgle per vg rkhtgd k` cerog lksupesnternes Xk gbserbk rpnlgok`tk per kd trghte lnakstnve

Dg gspnrn`g ks fnlrednzglg pgrhngdok`tk g hnle sgdnhdnhe lurg`tkkd prnokr pgse g trgvs lkd fagle y sk lnstrnbuyk gopdngok`tkper teles des tkmnles lkd erag`nsoe


>$


5/28

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GBXERHN@=

Des sgdnhndgtes n`akrnles sk gbserbk` he` rgpnlkz$ k` pgrtkk` kd kstogae pkre k` su ogyer pgrtk de fghk` k` dgperhn` supkrner lkd n`tkstn`e lkdagle Dg vkdehnlgl lk

gbserhn` lkpk`lk lk dg vkdehnlgl lk lksn`tkarghn` ylnseduhn` lk tgbdktgs$ kd pF lk dgs supkrcnhnks ouhesgs ykd tnkope lk vghngonk`te astrnhe Dg prksk`hng lkgdnok`tes rktrgsg dg gbserhn` lk des sgdnhndgtes

Xontf H$ Rky`grl G Cgroghedeag Klnterngd olnhg Zg`gokrnhg`g &Oglrnl.97>>8


6/28

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KDNON@GHNE@=

Des sgdnhndgtes sk kxhrktg` per ern`g y des oktgbedntes quk sk puklk`k`he`trgr k` lnstn`tgs preperhne`ks se`=

Ghnle sgdnhdnhe dnbrk 37 +

Ck`ed sgdnhndaruhure`ne 22 + Ghnd sgdnhndaruhure`ne ; + Ghnle sgdnhndurnhe 6 + Ghnle ak`tnsnhe 7 + Ghnle 2$8/lnfnlrexnbk`zenhe vkstnanes 2$8$;/trnfnlrexnbk`zenhe vkstnanes &8.


>$


7/28

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LNX\RNB[HN@=Des sgdnhndgtes sk lnstrnbuyk` k` teles des tkmnles herpergdks y dqunlestrg`shkdudgrks Des vedok`ks lk lnstrnbuhn` lk lesns herrnk`tks lkgspnrn`g k` sumktes `erogdks se` lk 71: oD%Ia lk pkse herpergd

BNE\RG@XCEROGHN@=

Des sgdnhndgtes se` bnetrg`scerogles k` ouhfes tkmnles Des trkspreluhtes oktgbdnhes prn`hnpgdks se` kd hnle sgdnhndrnhe9 kdaduhur`nle lk tkr e ck`dnhe$ y kd aduhur`nle lk stkr e ghnde


>$


8/28

Hgrghtkrstnhgs cgroghedanhgs lk dggspnrn`g=

Hgrghtkrstnhgs cgroghedanhgs lkghnle sgdnhdnhe=

Croghe= hnle ghktndsgdnhdnheSnlg oklng lk kdnon`ghn`= 7; g 2:on`utes

Kxhrkhn` urn`grng lk croghe

n`gdtkrgle= 4 2+\exnhnlgl= ;::: g 7;:::oaBnelnspe`nbndnlgl= lk ;: g 1;+gdhg`zg dg hnrhudghn` snstonhg

\nkope lk oxnog he`hk`trghn`pdgsotnhg lk sgdnhndgtes k` sukre= 7

g 2 fergsKxhrkhn`= ern`g &gprexnoglgok`tk7:+. heoe sgdnhndgtes

Croghe= ghnle sgdnhdnheSnlg Oklng lk kdnon`ghn`= 2/8 fergsKxhrkhn` urn`grng lk croghen`gdtkrgle=

\exnhnlgl= 2::oa\nkope lk oxnog he`hk`trghn`lk pdgsotnhg lk sgdnhndgtes k`sukre= 6;+Kxhrkhn`= ern`g 7:+


9/28

- G dg preperhn` lkd croghe quk sk gbserbk g dg hnrhudghn`

ak`krgd lkspus lk dg glon`nstrghn` lk u` oklnhgok`te y kdtnkope quk rkqunkrk pgrg fghkrde

CGH\ERKX W[K N@CD[^K@ K@ DG BNELNXZE@NBNDNLGL

Xumktes lk kstulne Cerog cgroghutnhgSgrngbndnlgl bnedanhgSgs lk glon`nstrghn`

LesnspF

Klgl@utrnhn`Ak`kre

Kxhnpnk`tksLesncnhghn`

He`hk`trghn`

Aeelog` A Dgs bgsks cgroghedanhgs lk dg tkrgputnhg 6 Kl Olnhg Zg`gokrnhg`g Okxnhe

7>>7


10/28

-Des pgroktres utndnzgles k` dg lktkron`ghn` lk bnelnspe`nbndnlgl lk u`croghe e lk u`g cerog cgroghutnhg n`hduyk`=

Lgtes lk pdgsog

Kd tnkope k` quk sk k`huk`trg kd pnhe lk dg he`hk`trghn` pdgsotnhg&togx.

Kd pnhe lk dg he`hk`trghn` pdgsotnhg &Hogx.

Kd rkg Bgme dg Hurvg lkd `nvkd pdgsotnhe he`trg tnkope &GBH.

Lgtes lk ern`g

Dg hg`tnlgl lk croghe kxhrktgle k` dg ern`g

Dg rgz` lk dg kxhrkhn` k` ern`g lkd croghe Kd tnkope oxnoe lk kxhrkhn` urn`grng

Aeelog` A Dgs bgsks cgroghedanhgs lk dg tkrgputnhg 6 Kl Olnhg Zg`gokrnhg`g Okxnhe

7>>7


11/28

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Kvgdugr y heopgrgr dg bnelnspe`nbndnlgl

lkd ghnle ghktndsgdnhdnhe$ glon`nstrglehe` les lnckrk`tks vkfhudes &gaug yrkcrkshe lk hedg.


12/28

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Lkoestrgr quk dgs tgbdktgs lk GGX huopdk` he` dgskspkhncnhghne`ks lk dg CK[O 7: klnhn`

Lktkron`gr dg he`cngbndnlgl lkd otele g`gdtnhepgrg hug`tncnhgr sgdnhndgtes per kd otele lk \rn`lkr

Lktkron`gr dg bnelnpe`nbndnlgl lk GGX he` gaug y he`

rkcrkshe lk hedg


13/28

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Dg gspnrn`g ks u`e lk des oklnhgok`tes lk ogyerhe`suoe k` kd ou`le

Ghtugdok`tk des rkcrkshes lk hedg se` lk ogyer

he`suoe g `nvkd ou`lngd

Kd he`suoe lk rkcrkshe k` dg pebdghn` okxnhg`g ks gdtek` teles des arupes lk klgl

Zer de hugd ks lk arg` nopertg`hng he`ehkr kd argle lk

gdtkrghn` k` dg bnelnspe`nbndnlgl lk dg gspnrn`g gd

he`suonrsk he` gaug y he` rkcrkshe lk hedg

Xhfek` BZ\fk Qerdls Oest Zewkrcud Brg`ls Dnsts \feose` Rkutkrs Cu`lgok`tgds Yskrnk k`d`kg_Yhntgle=2:78 Ckbrkre 7_9 Lnspe`nbdk lk= fttp=%%wwwcerbksheo%pewkrcud/brg`ls%dnst%

Hkrvg`tks O. Zgtr` lk he`suoe lk rkcrkshes k` u`g pebdghn` okxnhg`g. Xgd Zub Okx 7>>; mud9 81&
http://www.forbes.com/powerful-brands/list/http://www.forbes.com/powerful-brands/list/http://www.forbes.com/powerful-brands/list/http://www.forbes.com/powerful-brands/list/


14/28

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Kxnstnr` lnckrk`hngs sna`ncnhgtnvgs k` dg bnelnspe`nbndnlgl lkGGX gd glon nstrgrsk he` gaug e he` rkcrkshe lk hedg

Fe= Dgs oklngs lkd pkrnele y lk dg skhuk`hng se` naugdks$ dg

bnelnspe`nbndnlgl ks naugd

Fg= Dgs oklngs lkd pkrnele y lk dg skhuk`hng se` lnckrk`tks$ dg

bnelnspe`nbndnlgl ks lnckrk`tk


15/28

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\npe lk kstulne

Ghtntul lkdn`vkstnagler

Cerog lkrkhedkhhn` lkn`ceroghn`

Xkhuk`hngtkopergd lkdkstulne

Hg`tnlgl lkpebdghne`ks

@eobrk lkdpretehede

Kxpkrnok`tgd Zrespkhtnve De`antuln`gd Heopgrgtnve Kstulnekxpkrnok`tgdgdkgternehe`tredgle

Xgopnkrn RF Okteledeag lk dg N`vkstnaghn`


16/28

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Zebdghn` =

\gbdktgs lk ghnle ghktndsgdnhdnhe ;::oa

Xumktes lk prukbg


17/28

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\gbdktgs lk hnle ghktndsgdnhdnhe ogrhg heokrhngdgspnrn`g lk ;::oa

\gbdktgs lk gspnrn`g he` oxnoe u` ge lk vnak`hng

Zkrse`gs hd`nhgok`tk sg`gs quk `e prksk`tk`sk`snbndnlgl gd croghe lk kstulne

Sedu`tgrnes lkd onsoe skxe

Des vedu`tgrnes lkbk` tk`kr klglks k`trk 76 y ;;ges$ he` u` pkse 7:+ lkd nlkgd

Des vedu`tgrnes lkbk` cnrogr u`g hgrtg lk ghkptghn`


18/28

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Rupturg lkd heopdkme hedernle k` dg oukstrg g

g`gdnzgr

Xumktes quk prksk`tk` rkghhne`ks glvkrsgslurg`tk kd kstulne


19/28

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Zrlnlg lk dg oukstrg lk ern`g

Rkghhne`ks glvkrsgs k` vedu`tgrnes

Rktnre vedu`tgrne lkd sumkte

He`suoe lk croghes$ tgbghe$ gdhefed ygdnok`tes lurg`tk dgs dtnogs 7: fergs g dg

prukbg


20/28

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Glqunrnr\gbdktgs Rkgdnzgr g`dnsns lkhe`tred lk hgdnlgl

Kstulne lkbnelnspe`nbndnlgl Sgdnlghn` lkd otele

2: g 23: a%oD

Lurkzg

Lksn`tkarghn`

Sgderghn`

Crngbndnlgl

Lktkron`ghn`lk sgdnhndgtes Otelelk \rn`lkr

Zrkhnsn` Dn`kgdnlgl Kxghtntul


21/28

\nkope N`lnhghn` OukstrgGyuè lk 7: fergs

:1=::=:: GO \eog lk dg prnokrg oukstrgNàkrnr =::=:: GO \eog lk oukstrg y teogr 2:: oDlk gaug

7

7:=::=:: GO \eog lk oukstrg y teogr 2:: oDlk gaug

2

Nàkstg lk Gdnok`tes

77=::=:: GO \eog lk oukstrg y teogr 2:: oDlk gaug

8

72=::=:: GO \eog lk oukstrg y teogr 2:: oDlk gaug

=::=:: ZO \eog lk oukstrg >

Nàkstg lk Gdnok`tes77=::=:: ZO \eog lk oukstrg 7:

6=:: go lg snaunk`tk \eog lk oukstrg 77


22/28

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Cu`lgok`teDg oukstrg sk trgtg he` kd rkghtnve lk \rn`lkr$ quk he`tnk`khderure okrhrnhe pgrg prkhnpntgr dgs pretk`gs$ y `ntrgte crrnhe pgrgpreluhnr he` des sgdnhndgtes he` u` heder prpurg

\rn`lkr Z Rgpnl lktkron`gtne` ec Xgdnhydgtk n` Bnedeanhgd Cdunls Bnehfko M 7>;< Mu`k9

;1&2.= 8:7

8:8


23/28

7 K` u` tube lk k`sgyk hedehgr 7 od lk oukstrg lk ern`g

2 Glnhne`gr ; od lkd rkghtnve pgrg lksgrreddgr heder$ gantgrdg oukstrg lurg`tk 7 on`

8 Hk`trncuagr lurg`tk ; on` g 2;:: rpo


24/28

-H[GLRE DG\N@E

Ogrquks OM Zrebgbndnlgl y Kstglstnhg pgrg Hnk`hngs Wuonhe Bnedanhgs Oxnhe7>>6

Zkrele7

Dgvgle1l

gs

2

Rkpktnhn` 7

G BG BG BG B

Rkpktnhn` 2B GB GB GB G

Lnske hruzgles$ kxtk`sn` lk lnske lk huglre dgtn`e

Xk utndnzg kd oelkde hruzgle pgrg lkoestrgr quk dg lnckrk`hng k`trk

des trgtgonk`tes ks n`lkpk`lnk`tk lk dg skhuk`hng lk glon`nstrghn`


25/28

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Lnske huglre dgtn`e

Hugtre u`nlglks kxpkrnok`tgdks=rkpdnhg$ pkrnele$ skhuk`hng y trgtgonk`te.

nmid? ) Xn ) Rm &n.) Zi )d ) klncZgrg kd g`dnsns lk rksudtgles sk utndnzg u`g tgbdg lkG@LKSG y kstg kvgdugrg dg n`tkrckrk`hng lk dg rkpdnhg$

pkrnele$ skhuk`hng y trgtgonk`te

Ogrquks OM Zrebgbndnlgl y Kstglstnhg pgrg Hnk`hngs Wuonhe Bnedanhgs Oxnhe7>>6


26/28

-\GBDG G@LKSG

Cuk`tk X.H ad O.H C

Xn &^n2% tr./&^2% t2r. t/7

XH s %ad s OHs%OHR

Rm &n.&^nm2 %t. &^n2% tr.

t &r/7. XHR %adR /

Zi &^i2

% tr./&^2% t2r. t/7 XHp %adp /

d&^d2% tr./&^2% t2r.

t/7 XH t %adt OHt %OH k

knmid per lnckrk`hng

\etgd ^nmi2 /&^2% t2r.

t2r/7 / /

Fe= Dgs oklngs lkd pkrnele y lk dg skhuk`hng se` naugdks$ dg

bnelnspe`nbndnlgl ks naugd

Fg= Dgs oklngs lkd pkrnele y lk dg skhuk`hng se` lnckrk`tks$ dgbnelnspe`nbndnlgl ks lnckrk`tk


27/28

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XKOG@GGhtnvnlgl 7 2 8 < ;

Rkvnsn` Bnbdnearcnhg

Kdgberghn` lkd Zretehede

Zrksk`tghn` lkd Zretehede &Xkon`grne.

Ebtk`hn` lk des Rkhurses y Glqunsnhn` lk Ogtkrngd

Hgpghntghn` lkd Zkrse`gd N`veduhrgle

Xkdkhhn` lk des Kdkok`tes lkd Kstulne

Lksgrredde lk des \rgtgonk`tes y Rkhepndghn` lkd N`ceroghn`

Zrehksgonk`te lk Lgtes

G`dnsns Kstglstnhe k N`tkrprktghn` lk Rksudtgles

Rklghhn` lkd N`cerok y K`trkag lkd Onsoe

Zrksk`tghn` lkd Xkon`grne Cn`gd


28/28

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Gnghfk MO Bnecgroghng Kl Ogùgd Oelkrè Oxnhe 7>68 Zga= 726$

7;:/7;1 Xkhrktgrng lk Xgdul Cgroghepkg lk des Kstgles [`nles Okxnhgès 7:

Klnhn` 2::62 Zgas=

7863/>1 Igtzuà B Cgroghedeag Bsnhg y Hd`nhg 6 Klnhn` Klnterngd= Ogùgd

Oelkrè 2::2 Zgas= 3>3/3>6 Dy`hf OM Oteles lk Dgbergterne 2 Klnhn` Klnterngd=

N`tkrgokrnhg`g Zga= >6 Wuk kstgbdkhk dgs prukbgs y

prehklnonk`tes pgrg lkoestrgr quk u` oklnhgok`te ks n`tkrhgobngbdk

Rkqunsntes quk lkbk` sumktgrsk des tkrhkres guternzgles quk rkgdnhk` dgsb

jonathan urbina soto-comparaciÓn de la biodisponibilidad de Ácido acetilsalicÍlico entre el...

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