Jiangsu Hengrui Medicine Co., Ltd

江苏恒瑞医药股份有限公司2006

Better medicines to people’s health

关爱人类健康

Jiangsu Hengrui Medicine Co., Introduction

Jiangsu Hengrui Medicine

Established: 1970 Head Office: Lianyungang ,Jiangsu, China President: Mr.Piaoyang Sun Employees : 1800 including: R&D 230

恒瑞医药始建于 1970 年，公司位于江苏连云港

董事长 孙飘扬

公司现有员工 2000 人，研发人员 230 人

Main Businesses Line

Hengrui mainly produces antineoplastics,cardiovascular, analgesic, antibiotics .Hengrui was the No. 1 Antineoplastic sales in China Market in 2003 、 2004. 恒瑞主要从事抗肿瘤药、心血管类药、镇痛类药、抗生素的生产。 2003 、 2004 年抗肿瘤药销量全国排名第一。

Hengrui Group

Jiangsu Hengrui Medicine Co., Ltd. Pharmaceuticals and R&D

Shanghai Hengrui Medicine Co., Ltd. Pharmaceuticals and R&D

☉

☉

成都 上海☉

连云港

Shanghai Hengrui Medicine &Shanghai Hengrui Medicine &Chengdu Hengrui MedicineChengdu Hengrui Medicine

Workshop & Equipment

Hengrui has two factory zones, the old one is located at Xinpu, the new one is located at ECO. & TECH Development Zone.

恒瑞现有两个厂区：新浦厂区 开发区新厂区

Workshop & Equipment

The Xinpu factory is the main area of synthesizing and producing bulk drugs, including two solid preparation which passed to GMP inspection and 6 bulk drugs workshops.

It can produce 20 kinds of chemical medicines 1.6 billion pills, 50 tons of 40 kinds of bulk drugs per year.

新浦厂区主要是固体制剂与原料药生产地，拥有 2 个通过 GMP 认证的固体制剂车间、 6 个原料车间。 年生产能力为西药 20 种 16 亿片，化学原料药 40 种 50 吨。

Head office

Workshop & Equipment

GMP 固体制剂车间 Solid Preparation

Workshop & Equipment

The new factory has an area of 30 thousand of square meters, which built preparation workshops according to GMP, and imported a batch of advanced equipment and production line. Now the factory is capable of producing 50 million injections, 2 million lyophilized powders and 2 million sterile split charging powder.

开发区新厂区占地 3 万多平方米，新建了符合 GMP 要求的制剂车间，并已引进了一批国外的先进设备仪器，新增年产针剂 5000 万支、冻干粉针 200 万瓶、灭菌分装粉针 200 万瓶的生产能力。

Capacity of Jiangsu Hengrui

50 million injections,

2 million lyophilized powders

2 million sterile split charging powder.

500 million troches

12 million transfusion bags

Freeze Dryer Imported from EDWARDS

Form-Fill-Seal Line

Solid Preparation Auto-Line

Auto-Packing Line

● 上海分公司 2004 年上半年建成投产。

Shanghai Hengrui was in production in Jun. 2004

Subsidiary company －－ Shanghai Hengrui

Shanghai Hengrui Campus

Sales Net

Sale network covers all of the country.

There are 62 sale offices inside China.

Salespersons are over 1300.

Active Pharmaceutical ingredients are mainly sold to USA and Europe.,

恒瑞有九个销售公司，在全国各地有 80 个办事处，

共有 1500 名销售代表

Jinagsu Hengrui Sales Status

Top 5 Products in 2004

020406080

100120140160180

Ai heng Tongao Lel ang Nuobang Ai su

Uni t: Mi l l i on RMB

● 2001 年恒瑞医药原料药异环磷酰胺、足叶乙甙、美司那、噻替派通过了美国 FDA 验证。

Ifosfamide, Etoposide, Mesna and Thiotepa

were approved by FDA in 2001.

FDA Approving

Export Status Of Raw Chemical Material

0

1000

2000

3000

4000

5000

6000

2001 2002 2003 2004 2005

Unit: ￥ Ten thousand(RMB)

R &D Activity 研究与开发恒瑞拥有 2 个研究中心 Hengrui Has Two R&D Centers

• 恒瑞连云港研究中心 Lianyungang R&D Center

人员 Researcher and Engineer ： 130 Persons

化学合成、植物药、中试研究、通用名药物 Chemical Synthesizing, Plant Drugs, Scale Test Before

Production, Generic Medicines

• 恒瑞上海研究中心 Shnaghai R&D Center

人员 Researcher and Engineer ： 60 Persons

药物设计、化学合成、制剂研究、生物工程 Drug Design ,Chemical Synthesizing, Preparation

Improvement,

Biology Engineering

R & D Activity 研究

化学药物 Chemical Medicine:

• COX-2 抑制剂 Inhibitor

BNP909 in Phase I

BNP811 in Preclinical

• 糖尿病 PPARγ 激动剂 Diabetes PPARγAgonist

• 抗肿瘤药物 Antineoplastics

• 胃动力药 Gastrokinetic

agents

• 抗生素 Antibiotics

R & D Activity 研究

植物药 Plant Drugs

• 肝病治疗药 Liver Treatment

Drugs

• 镇咳药 Antitussivers

• 妇科用药 Gynecological

Drugs

生物工程 Biology Engineering

• 单克隆抗体 Monoclonal Antibody

• 多肽合成 Polypeptide Synthesis

合作研究 R&D Cooperation

• 与美国 Chiron 公司合作研究

Cooperation Development with Chiron in

USA :

Eg5

• 与瑞典 Medvir 公司研究治疗

Cooperation with Medvir Co.,

in Sweden for Development

of COPD Medicine

Thanks !