Jacques Normand, Ph.D.Jacques Normand, Ph.D.

Director, AIDS Research ProgramDirector, AIDS Research Program

National Institute on Drug AbuseNational Institute on Drug Abuse

NIDA’s New HIV/AIDS Research Program

Objectives• Update on NIDA’s New AIDS Research

Program – CAMCODA– NIDA Council Recommendations– New AIDS Research Program

– Structure– Research Priorities

• Brief Update on NIDA/NIH Collaborative Projects– Projects and Partners– New HPTN Network Drug Abuse Projects

CAMCODA Structure

Director

Medical Consequence

Unit

Human Development

Unit

Population-Based

Intervention Unit

Deputy Director

Staff: 20 Professionals

CAMCODA 116,035,000

DESPR 57,707,000

DTR&D 54,204,000

DNBR 29,615,000

CTN 12,052,000

NIDA AIDS FY03 AIDS Funding by Divisions

NIDA Advisory Council Workgroup on HIV/AIDS

Report on Findings and Recommendations

February, 2004

Structural & Procedural Recommendations

• Create new position of “Director, AIDS Research Program” reporting to NIDA’s Director

• Update policy/procedures to determine which projects qualify for AIDS funding

• Improve articulation of HIV/AIDS mission and planning process within & across Divisions/Centers

• Increase interaction across NIH, and with extramural community

NIDA’s AIDS ResearchProgram Structure

AIDS Research ProgramMission: Plan, develop, coordinate and integrate research

priorities within NIDA and externally.

Staff: Jacques Normand

Lynda Erinoff

Helen Cesari

AIDS Workgroup AIDS Coding Subgroup

External Scientific AIDS Workgroup

TBA

Division of Pharmacotherapies and Medical Consequences of Drug Abuse

Jag Khalsa

Ahmed Elkashef

Jamie Biswas

Division of Basic Neurosciences and Behavioral Research

Diane LawrenceCora Lee WetheringtonCharles SharpYu LinMinda Lynch

NIDA’s AIDS Workgroup Membership

Division of Epidemiology, Services, and Prevention Research

Elizabeth Lambert

Division of Clinical Neurosciences, Development and Behavioral Treatment

Lisa OnkenMelissa RacioppoNicolette BorekRo Nemeth

Center for Clinical Trials Network

Mary Ellen Michel

NIDA’s AIDS Workgroup Membership (Cont.)

Office of Science Policy & CommunicationAnna Staton

International ProgramSteve Gust

Intramural Research ProgramJohn Schmittner

Office of Extramural AffairsMark Green

Office of Planning & Research ManagementStacy Gardner

NIDA’s AIDS Workgroup Membership (Cont.)

External Scientific AIDS Workgroup

Proposed Membership (~ 8):

Council Members

Nominee per Division/Center

Nominee from AIDS Program

Proposed Task:

Review NIDA’s AIDS Strategic Plan

Review & make recommendations on new AIDS related procedural change (e.g., definition of AIDS and coding guidelines)

Review NIDA’s priorities/initiatives

DPMC 52,046,000

DESPR 121,656,000

DCNDBT 46,336,000

DBNBR 29,374,000

CCTN 11,557,000

FY04 AIDS Funding byNIDA Divisions

NIDA’s FY04 Funding By OAR Research Areas of Emphasis

1. Natural History and Epidemiology $54,246,859

2. Etiology and Pathogenesis $29,028,598

3. Therapeutics $12,084,141

4. Vaccines $1,983,201

5. Behavioral and Social Science $186,583,465

6. Training, Infrastructure, and

Capacity Building $6,860,742

7. Information Dissemination $1,594,994

Research PriorityRecommendations

Racial/ethnic disparitiesEmphasize case finding/treatment HAART interactions/adherence/resistanceNewer HIV/IDU epidemics (Russia, China, India, Eastern Europe)

Test drug Tx for HIV preventionEmerging drugs (e.g., Meth/Viagra, NYC case/immunological & CNS impact )

Sexual risk behaviors (main exposure category)

Adolescents (developmental/decision making, impulsivity)

Role of drug abuse on transmission (drug type, partnership, context)

Update programs with continuous review of epidemiologic and other findings

Current NIDA’s AIDSProgram Tasks

• Explore new ways to attract new AIDS PIs • Better integrate HIV/AIDS within and across NIDA Divisions/Centers and other NIH Institutes• Working on Generating FY07 OAR Priorities (retooling priorities to establish strong presence in all Div/Ctr) • Will be Generating NIDA FY06 AIDS Initiatives • Developing Criteria for AIDS Grants• Will be Appointing Members to Extramural Scientific AIDS Workgroup• Will be Developing NIDA’s HIV/AIDS Strategic Plan

NIDA’s CollaborativeProjects

Network/Cohort Collaborating ICs NIDA’s Co-Fund

Adolescent Trial Network

NICHD, NIMH $1.0/20.0M

Pediatric HIV AIDS Cohort Study

NICHD, NIAID, NIMH

$3.0/12.0M

Centers For AIDS Research

NIAID, NCI, NHLBI, & NIMH

$4.6/33.3M

Women Interagency HIV Study

NIAID, NICHD, & NCI $0.5/18.5M

HIV Prevention Trial Network

NIAID,NIMH, NICHD, & FIC

$4.4/70.0M

HPTN & New NIAID Network

• Current ProjectsEpidemiologyHIV PreventionDrug Tx as HIV Prevention

• New Network Proposed protocols

Community Scale-up; Stimulant pharmacotherapy as HIV prevention