issn 1868-596x 1-116 (2012) altex

AltexVolume 29, No. 1ISSN 1868-596X

1-116 (2012)

1/2012

AlterNAtIVeS to ANImAl eXperImeNtAtIoN

Comment:Andrew Knight:Assessing the necessity of chimpanzee experimentation

Conference reportCornersNews Calendar of events

t4 report:D. A. Basketter, H. Clewell,

I. Kimber, A. rossi, B. Blaauboer, r. Burrier, m. Daneshian, C. eskes,

A. Goldberg, N. Hasiwa, S. Hoffmann, J. Jaworska,

t. B. Knudsen, r. landsiedel, m. leist, p. locke, G. maxwell,

J. mcKim, e. A. mcVey, G. ouédraogo, G. patlewicz,

o. pelkonen, e. roggen, C. rovida, I. ruhdel,

m. Schwarz, A. Schepky, G. Schoeters, N. Skinner,

K. trentz, m. turner, p. Vanparys, J. Yager,

J. Zurlo, and t. Hartung:A roadmap for the

development of alternative (non-animal)

methods for systemic toxicity testing

t4 – transatlantic think tank for toxicology: the concept

t4 was created with the following aims:• to analyze current tools and programs

and model/forecast the likely outcome with regard to safety and economic bur-den (cost/benefit analyses)

• to compare different approaches on an international scale (especially transat-lantic) and support harmonization

• to further the concept of an evidence-based toxicology (EBT) following the role model of evidence-based medicine

• to develop and assess the conceptual needs to enable the change of approach-es (predictive toxicology, integrated testing, systems toxicology, organotyp-ic, and stem cell cultures)

• to create and maintain information platforms (AltWeb, ALTEX, TestSmart workshops, etc.) to further the paradigm change in toxicology

t4 – transatlantic think tank for toxicology: the members

Alan Goldberg, Center for Alternatives to Animal Testing (CAAT), Johns Hop-kins University, Baltimore, USA;Thomas Hartung, Doerenkamp-Zbinden Chair for Evidence-based Toxicology, CAAT, Johns Hopkins University, Baltimore, USA, and CAAT-Europe, University of Konstanz, Germany;Marcel Leist, Doerenkamp-Zbinden Chair for in vitro Toxicology and Bio-medicine and CAAT-Europe, University of Konstanz, Germany;Bas Blaauboer, Doerenkamp-Zbinden Chair on Alternatives to Animal Test-ing in Toxicological Risk Assessment, IRAS, Utrecht University, The Nether-lands

All reviews and reports may be down-loaded from the ALTEX website (www.altex-edition.org) and AltWeb (www. altweb.jhsph.edu). Further in depth reviews of all toxicologically-relevant topics are encouraged. The reviews are commissioned by any t4 member. Inter-ested authors are advised to contact a relevant t4 member directly with a review proposal. Publication is subject to a two-step peer review process. Reviews will be published and made available to the public free of charge. Authors are eligible for an honorarium.

t4 reportsBasketter, D. A., Clewell, H., Kimber, I., et

al. (2012). A roadmap for the develop-ment of alternative (non-animal) meth-ods for systemic toxicity testing. ALTEX 29, 5-93.

Boekelheide, K. and Andersen, M. E. (2010). A mechanistic redefinition of adverse effects – a key step in the tox-icity testing paradigm shift. ALTEX 27, 243-252.

Dietrich, D. R. (2010). Courage for sim-plification and imperfection in the 21st

century assessment of “Endocrine dis-ruption”. ALTEX 27, 264-278.

Hartung, T. (2010a). Evidence-based toxi-cology – the toolbox of validation for the 21st century? ALTEX 27, 253-263.

Hartung, T. (2010b). Comparative analysis of the revised Directive 2010/63/EU for the protection of laboratory animals with its predecessor 86/609/EEC – a t4 report. ALTEX 27, 285-303.

Hartung, T., Blaauboer, B. J., Bosgra, S., et al. (2011). An expert consortium re-view of the EC-commissioned report “Alternative (Non-Animal) Methods for Cosmetics Testing: Current Status and Future Prospects – 2010”. ALTEX 28, 183-209.

Jaworska, J. and Hoffmann, S. (2010). Integrated Testing Strategy (ITS) – Op-portunities to better use existing data and guide future testing in toxicology. AL-TEX 27, 231-242.

Kuegler, P. B., Zimmer, B., Waldmann, T., et al. (2010). Markers of murine embry-onic and neural stem cells, neurons and astrocytes: reference points for develop-mental neurotoxicity testing. ALTEX 27, 17-42.

Leist, M., Bremer, S., Brundin, P., et al. (2008). The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell ther-apy. ALTEX 25, 163-190.

Rovida, C. and Hartung, T. (2009). Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the transatlantic think tank for toxicology (t4). ALTEX 26, 187-208.

Rovida, C., Longo, F., and Rabbit, R. R. (2011). How are reproductive toxicity and developmental toxicity addressed in REACH dossiers? ALTEX 28, 273-294.

t4 workshop reportsDaneshian, M., Akbarsha, A. M., Blaaubo-

er, B., et al. (2011). A framework pro-gram for the teaching of alternative methods (replacement, reduction, refine-ment) to animal experimentation. AL-TEX 28, 341-352.

Hasiwa, N., Bailey, J., Clausing, P., et al. (2011). Critical evaluation of the use of dogs in biomedical research and testing in Europe. ALTEX 28, 326-340.

Silbergeld, E. K., Contreras, E. Q., Har-tung, T., et al. (2011). Nanotoxicology: “The end of the beginning” – Signs on the roadmap to a strategy for assuring the safe application and use of nanoma-terials – t4 workshop report. ALTEX 28, 236-241.

Zurlo, J. , Bayne, K. A., Brown, D. C., et al. (2011). Critical evaluation of the use of dogs in biomedical research and testing. ALTEX 28, 355-359.

ebtcEvidence-based Toxicology Collaboration

This SOT satellite meeting is open to all SOT attendees and is an opportunity for participants to provide informal updates on the work they are doing to advance the new toxicology. Participants may augment their brief presentations (5 minutes) with Powerpoint slides.

Refreshments will be provided.

The Open Forum is co-hosted by the Center for Alternatives to Animal Testing (CAAT), the Human Toxicology Project Consortium, and the Evidence-based Toxicology Collaboration (EBTC).

To register and receive updates on this free event, contact Marilyn Principe ([email protected]).

Attending the Society of Toxicology Annual Meeting in San Francisco, California on March 11-15, 2012?

You are invited to participate in the Open Forum on 21st Century Toxicology and Evidence-based Toxicology

Sunday, March 11, 1-4pm Marriott Marquis55 Fourth StreetSan Francisco, CA 94103Salon 1-3

ALTEX – Reduced Subscription RatesSpecial Reduced Rates for Selected Scientific Societies and Animal Welfare Organizations

Selected contents of ALTEX are available online: http://altweb.jhsph.edu/altex and www.altex.ch

EUROPE Subscription service Europe: ALTEX Edition, Weinmanngasse 86, 8700 Kuesnacht ZH, Switzerland Tel.: +41-44-380 0830, Fax: +41-44-380 0832, e-mail: [email protected]

USA Subscription service USA: Center for Alternatives to Animal Testing (CAAT), 615 N. Wolfe St. W7032, Baltimore, MD, 21205, USA. Phone: 410-614-4990, Fax: 410-614-2871, e-mail: [email protected]

INDIASubscription service India: Mahatma Gandhi Doerenkamp Center (MGDC) for Alternatives to Use of Animals in Life Science Education, Bharathidasan University, Tiruchirappalli - 620 024, India. Phone: +91 9790995854, Fax: +91 431 2407045, e-mail: [email protected]

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Four issues:❑ Standard subscription $ 120 / 85 € ❑ Library $ 240 / 170 € (companies, institutes, libraries)❑ Student $ 62 / 46 € (please fax proof of student status)❑ Society members $ 62 / 46 € (members of selected scientific societies and animal welfare organizations, please ask)❑ Subscription in IndiaPlease ask for special prices for a subscription in India

Prices include postage for USA, all European countries and India. Additional costs for shipment outside of USA, Europe and India: 20 €.

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AltexVolume 28, No. 1ISSN 1868-596X1-80 (2011)

1/2011


Neil Wilcox and Alan Goldberg:

Food for thought ...

on validation. A puzzle or

a mystery: an approach

founded on new scienceKevin m. Crofton, William r.

mundy, pamela J. lein et al.:

Developmental

neurotoxicity testing: Recommendations

for developing alternative

methods for the screening and prioritization of chemicals erwin van Vliet:

Current standing

and future prospects for

the technologies proposed to transform toxicity

testing in the 21st century

CommentConference reportCornersNews

Calendar of events

Highlights of WC7 – part 3mark t. D. Cronin,

Steven J. enoch, mark Hewitt

and Judith C. madden:Formation of mechanistic

categories and local models to facilitate the

prediction of toxicityGavin maxwell, pierre Aeby,

takao Ashikaga et al.:Skin sensitisation: the Colipa strategy for developing and evaluating non-animal

test methods for risk assessment philippe Vanparys,

raffaella Corvi, marilyn Aardema et al.:eCVAM prevalidation

of three cell transformation assays

altex_2011_1_u1_u1_Titel.indd 1

4.2.2011 19:19:16 Uhr

AltexVolume 28, No. 2ISSN 1868-596X81-172 (2011)

2/2011

AlterNAtIVeS to ANImAl eXperImeNtAtIoNthomas Hartung andmary mc Bride: Food for thought …on mapping the human toxome

troy Seidle, pilar prietoand Anna Bulgheroni:examining the regulatory value of multi-route mammalian acute systemic toxicity studies

raija H. Bettauer: Systematic review of chimpanzee use in monoclonal antibody research and drug development: 1981-2010

Costanza rovida:local lymph Node Assay: How testing laboratories apply OeCD tG 429 for ReACH purposesKaty taylor, Carlotta Casalegnoand Wolfgang Stengel:A critique of the eC’s expert (draft) reports on the status of alternatives for cosmetics testing to meet the 2013 deadline

Conference reportsCornersNews Calendar of events


15.5.2011 20:55:55 Uhr

AltexVolume 28, No. 3ISSN 1868-596X

173-264 (2011)

3/2011


Food for thought …melvin e. Andersen,

Harvey J. Clewell, III, paul l. Carmichael, and

Kim Boekelheide:Can case study approaches

speed implementation of the NRC report: “toxicity

testing in the 21st Century:

A Vision and a Strategy?”

Joanna Jaworska, Artsiom Harol, petra S. Kern,

and G. Frank Gerberick:Integrating non-animal test

information into an adaptive testing strategy

– skin sensitization proof of concept case

t4 report:thomas Hartung, Bas J. Blaauboer,

Sieto Bosgra, et al.:An expert consortium

review of the eC-commissioned report

“Alternative (non-animal) methods for cosmetics

testing: current status and future prospects – 2010”

rolando perdomo-morales, Zenia pardo-ruiz, Ingo Spreitzer, Alicia lagarto, and thomas montag:Monocyte activation test (MAt) reliably detects pyrogens in parenteral formulations of human serum albumin

t4 workshop report:ellen K. Silbergeld, elizabeth Q. Contreras, thomas Hartung, et al.:Nanotoxicology: “the end of the beginning”

– Signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials

lettersCornersNews Calendar of events


12.9.2011 20:43:59 Uhr

AltexVolume 28, No. 4

ISSN 1868-596X

265-376 (2011)

4/2011


Food for thought …

paul A. locke and

D. Bruce myers, Jr:

A replacement-first

approach to toxicity

testing is necessary

to successfully

reauthorize tSCA

t4 report:

Costanza rovida,

Fabiola longo and

richard r. rabbit:

How are reproductive

toxicity and developmental

toxicity addressed in

ReACH dossiers?

maría moreno-Villanueva,

tobias eltze, Dirk Dressler, et al.:

the automated

FADU-assay, a potential

high throughput

in vitro method for early

screening of clastogenicity

Caroline rauch, elisabeth Feifel,

eva-maria Amann, et al.:

Alternatives to the use

of fetal bovine serum:

Human platelet lysates

as a serum substitute

in cell culture medium

Jenny Stracke, Bettina Bert,

Heidrun Fink, and Jörg Böhner:

Assessment of stress

in laboratory

Beagle dogs constrained

by a Pavlov sling

t4 report:

Nina Hasiwa, Jarrod Bailey,

peter Clausing, et al:

Critical evaluation of

the use of dogs in

biomedical research

and testing in europe

t4 report:

mardas Daneshian,

mohammad A. Akbarsha,

Bas Blaauboer, et al.:

A framework program for

the teaching of alternative

methods (replacement,

reduction, refinement) to

animal experimentation

t4 report:

Franz p. Gruber:

the Basel Declaration:

a critical appraisal

Workshop reports

Congress report

CornersNews Calendar of events

r-altex_2011_4_u1_u1_Titel.indd 1

24.11.2011 19:45:04 Uhr

issn 1868-596x 1-116 (2012) altex

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