international conference: korean s m cellular...

1KSMCBCelebrating the 30th Anniversary

www.ksmcb.or.kr

2019International Conference:KoreanSociety forMolecular andCellularBiology

September 30 (Mon) - October 2 (Wed), 2019Coex, Seoul, Korea

Symposia : Conference Room (3F-4F)Exhibition & Poster Presentation: Hall D2 (3F)

Pre-registration & Abstract Submission: June 10 – August 16, 2019

| Plenary Lectures |

| Nobel Laureate Lectures |

The Century of Vision: Protein Structures in Basic Science and Pharma Research Robert Huber, Ph.D. (Max Planck Institute of Biochemistry, Germany) *1988 Nobel Laureate

Looking Back on My 30 years’ Autophagy ResearchYoshinori Ohsumi, M.D., Ph.D. (Institute of Innovative Research(IIR), Tokyo Institute of Technology, Japan) *2016 Nobel Laureate

To Fold or not To Fold: the Yin and Yang of Chaperone-Mediated Client ActivationDavid A. Agard, Ph.D. (University of California, San Francisco, USA)

Toward the Mysteries of SleepMasashi Yanagisawa, M.D., Ph.D. (University of Tsukuba, Japan)

Leveraging Brain Rhythms as a Therapeutic Intervention for Alzheimer’s DiseaseLi-Huei Tsai, Ph.D. (Massachusetts Institute of Technology, USA)

Korean Society for Molecular and Cellular Biology

2019 International Conference: Korean Society for Molecular and Cellular Biology

Contents

1. Invitation ··································································································································· 5

2. Schedule ·································································································································· 6

3. Call for Abstracts ····················································································································· 8

4. Awards ··································································································································· 10

5. General Information ·············································································································· 12

6. Plenary Lectures ··················································································································· 13

7. Symposia ································································································································ 18

8. Luncheon Symposia ·············································································································· 44

4 2019 International Conference: Korean Society for Molecular and Cellular Biology

KSMCB Organizing Committee

Title Name / Affiliation

President

Young-Joon Surh (Seoul Nat’l Univ., Korea)

Senior Vice President

Jin Won Cho (Yonsei Univ., Korea)

Senior Vice President

Sunjoo Jeong (Dankook Univ., Korea)

Kwon-Soo Ha (Kangwon Nat’l Univ., School of Medicine, Korea)

Young-Kug Choo (Wonkwang Univ., Korea)

Secretary General

Kisung Ko (Chung-Ang Univ., Korea)

Vice Secretary General

You-Sun Kim (Ajou Univ. School of Medicine, Korea)

Chair of Committees

Scientific Program Committee Jae Bum Kim (Seoul Nat’l Univ., Korea)

Finance Committee Young Hun Song (Ajou Univ., Korea)

Planning Committee Sang-Kyu Ye (Seoul Nat’l Univ., Korea)

Mol. & Cell. Biol. News Committee

In-Chul Park(Korea Inst. of Radiological and Medical Sciences)

Publication CommitteeTaeg Kyu Kwon(Keimyung Univ., School of Medicine, Korea)

International Affairs Committee Hye-Kyung Na (Sungshin Women’s Univ., Korea)

External Cooperation Committee Kwang-Hee Bae (KRIBB, Korea)

Election Management Committee Kang-Yell Choi (Yonsei Univ., Korea)

Academic Research Awards Committee

Chang-Duk Jun(Gwangju Inst. of Science and Technology, Korea)

Network Affairs Committee Byung Heon Lee (Kyungpook Nat’l Univ., Korea)

Ethic Committee Jung Weon Lee (Seoul Nat’l Univ., Korea)

Ilchun CommitteeJong-Il Kim(Seoul Nat’l Univ., College of Medicine, Korea)

Welfare Committee Dae-Jin Yun (Konkuk Nat’l Univ., Korea)

Committee for Advancement Joohong Ahnn (Hanyang Univ., Korea)

Winter Conference Program Committee Eekhoon Jho (The Univ. of Seoul, Korea)

Title Name / Affiliation

Education Committee Sun Choi (Ewha Women’s Univ., Korea)

Chapter Committee Yong Tae Kwon (Seoul Nat’l Univ., Korea)

Publicity Committee Suk Kyeong Lee (Catholic Univ., Korea)

Policy Committee Seungbok Lee (Seoul Nat’l Univ., Korea)

Membership Committee Yun Kee (Kangwon Nat’l Univ., Korea)

Manager of Committees

Treasurer Young Hun Song (Ajou Univ., Korea)

Scientific Program Committee

Jung-Shin Lee (Kangwon Nat’l Univ., Korea)

Hyukjin Cha (Seoul Nat’l Univ., Korea)

Finance Affairs Yoon Ki Kim (Korea Univ., Korea)

Planning AffairsDong-Hoon Jin (Univ. of Ulsan College Medicine, Asan Medical Center, Korea)

Mol. & Cell. Biol. News Affairs Byeong-ha Lee (Sogang Univ., Korea)

Publication Affairs Mi-Ryoung Song (GIST, Korea)

International Affairs G-One Ahn (POSTECH, Korea)

External Cooperation Affairs Won-Kon Kim (KRIBB, Korea)

Election Management Affairs Jin Woo Kim (KAIST, Korea)

Academic Research Awards Affairs Chul-Kyu Park (Gachon Univ., Korea)

Network Affairs Sangmyung Rhee (Chung-Ang Univ., Korea)

Ethic Affairs Nayoung Suh (Soonchunhyang Univ., Korea)

Ilchun Affairs Youn Soo Choi (Seoul Nat’l Univ., Korea)

Welfare Affairs Kyung-Soo Chun (Keimyung Univ., Korea)

Advancement Affairs Ji Hoon Ahn (Korea Univ., Korea)

Winter Conference Program Affairs

Min Jae Lee (Seoul Nat'l Univ., Korea)

Choel-Sang Hwang (POSTECH, Korea)

Education AffairsHan Kyoung Choe (DGIST, Korea)

Woochul Chang (Pusan Nat’l Univ., Korea)

Chapter Affairs Ho Chul Kang (Ajou Univ., Korea)

Publicity Affairs Eun Sook Hwang (Ewha Womans Univ., Korea)

Policy Affairs Donghak Kim (Konkuk Nat’l Univ., Korea)

Membership Affairs Byung Woo Han (Seoul Nat’l Univ., Korea)

+ Molecules and Cells (Mol. Cells)| Editor-in-Chief |

Jongkyeong Chung (Seoul Nat’l Univ., Korea)| Associate Editors |

Daehee Hwang (Seoul Nat’l Univ., Korea)Goo Taeg Oh (Ewha Womans Univ., Korea)Ildoo Hwang (POSTECH, Korea)In-Kyu Lee (Kyungpook Nat’l Univ., Korea)Jae Bum Kim (Seoul Nat’l Univ., Korea)Ja-Hyun Baik (Korea Univ., Korea)Jie-Oh Lee (POSTECH, Korea)Eun-Kyeong Jo (Chungnameong Nat’l Univ. Korea)Suk-Chul Bae (Chungbuk Nat’l Univ., Korea)Sunjoo Jeong (Dankook Univ., Korea)Young-Yun Kong (Seoul Nat’l Univ., Korea)

+ One of the- Leading online open-access journals in the life science- Indexed in Science Citation Index (SCI)- International readership- Spans the breath of molecular and cellular biology- Monthly publication- Rapid review- URL : http://www.molcelles.org- eISSN - 0219-1032* Impact factor 3.077

KSMCB


Invitation

On behalf of the Korean Society for Molecular and Cellular Biology (KSMCB), I cordially invite you to participate in the annual International Conference of KSMCB, which will take place from September 30 to October 2, 2019 at the COEX Convention Center in Seoul, South Korea, which is located in the heart of Gangnam, a business, entertainment, shopping, and culture district.

The utmost purpose of our annual conference is to provide the scientific platform for sharing cutting edge knowledge with all participants, which will integrate expertise in the sciences of Molecular Biology, Medicine, Pharmacy, Fisheries and Agriculture, Food Sciences and Biotechnology, etc.

This year’s annual international conference will celebrate the 30th year anniversary of our society, and we plan to organize very special scientific and social programs. We’ve invited world-renowned scholars including two Nobel Laureates (Yoshinori Ohsumi and Robert Huber) and three world-class speakers (David A. Agard, Masashi Yanagisawa, and Li-Huei Tsai). In addition, there will be a series of major symposia, workshops, luncheon seminars, and award lectures that focus on the latest research breakthroughs. More than 150 researchers from domestic and foreign institutions will present their ongoing studies and activities during the conference. On top of that, over 1,200 posters will be presented by young scientists, introducing their research progress. Moreover, a series of academic ceremonies and social programs are arranged. These include Opening Ceremony celebrating the 30 year anniversary of KSMCB, Presidential Dinner, Welcome Reception, and Ceremonies for the academic research awards, travel grant awards, and the outstanding platform and poster presentation awards for the young domestic and international participants.

Besides the aforementioned programs, many companies, organizations and industries in the field of biomedical sciences will participate as major sponsors in the exhibition of research materials, equipments, innovative technologies, activities, etc.

I am confident that this conference will be the exciting and memorable scientific festival, which provides all attendees with the most up-to-date information on the latest scientific achievements and will facilitate collaborative networking among the domestic and international scientists.

I look forward to meeting you this Fall in Seoul at the annual International Conference of the KSMCB celebrating its 30 year anniversary.

Young-Joon Surh, Ph. D.

2019 PresidentKorean Society for Molecular and Cellular Biology


Schedule (tentative) KSMCB

Start End Rm. 300 Rm. 307 Rm. 308 Rm. 401 Rm. 4029:00 9:30 Registration

9:30 11:30

Sym. 01Cell Cycle and

Genome Stability

Sym. 02Cilia in Development

and Diseases

Sym. 03Metabolic and

Proteostatic Regulation of Aging and Age-

associated Diseases

Sym. 04Targeting

Tumor & Tumor Microenvironment for

Cancer Therapy

Sym. 05Frontiers of Structural

Biology

11:30 13:00 Global Network Session Break and Lunch13:00 13:20 Opening Ceremony (Rm. 401)13:20 14:10 Plenary Lecture I (Rm. 401): David A. Agard14:10 14:20 Break

14:20 16:20

Sym. 06Plant Molecules in

Motion

Sym. 07Forces in Cell Biology

Sym. 08Gendered Innovation in Biomedical Research

Sym. 09Using Light and Genetic

Tools to Interrogate Neural Circuits

Sym. 10New Technologies to

Overcome Antimicrobial Resistance

16:20 16:40 Break16:40 17:30 Plenary Lecture II (Rm. 401): Masashi Yanagisawa

Start End Rm. 300 Rm. 307 Rm. 308 Rm. 401 Rm. 402Hall D2(3F)

Poster/Exhibition8:00 9:10 Registration

Poster Posting 1 (09:00-18:00)

*Poster Presentation 1(13:10-15:00)

9:10 11:10

Sym. 11Plant Immunity

Sym. 12Microbiome and

Mouse Model

Sym. 13New Players in B cell-T cell Interactions

Sym. 14 Epigenetics and

Transcription

Sym. 15RNA Biology

11:10 11:30 Break11:30 12:20 Plenary Lecture III (Rm. 401) : Yoshinori Ohsumi

12:20 13:10AMOREPACIPFIC Great Global Next Generation

Research Award Lectures

MERCK 350 Future Researcher Award

Lectures

Company Workshop 1 (Luncheon)

IVIM Technology’s IntraVital Microscopy (IVM)

: In Vivo Live Cell Imaging Platform & Solution

KSMCBCouncil Meeting

13:10 13:35Break & Poster Viewing (Hall D2)

13:35 15:0015:00 15:50 Plenary Lecture IV (Rm. 401): Robert Huber15:50 16:00 Break

16:00 18:00

Sym. 16AI & Data Driven Drug

Discovery (AI-D4)

Sym. 17Dynamics and Traffic of

Intracellular Membranes

Sym. 18Generation of Cellular

Diversity in Neural Development

Sym. 19Moleucular/Cellular

Cancer Biology

Sym. 20Circadian Clock in

Physiology and Behavior

18:00 19:00

Start End Rm. 300 Rm. 307 Rm. 308 Rm. 401 Rm. 402Hall D2(3F)

Poster/Exhibition8:00 9:10 Registration

Poster Posting II (09:00-17:00)

*Poster Presentation II(13:10-15:00)

9:10 11:10Sym. 21

Bioactive Lipids inHealth and Disease

Sym. 22Plant Genome Editing

Sym. 23Immunometabolism

Sym. 24Signal Transduction

Sym. 25Brain Dysfunction and

Infectious Disease

11:10 11:30 Break11:30 12:20 Plenary Lecture V (Rm. 401) : Li-Huei Tsai

12:20 13:10ABL Bio, an Innovative

Biotechwith its Strong Proprietary

Technologies

Research Ethics Sym. (Korean)

Takara Excellence Thesis Award Lectures

KSMCB General Assembly

SeouLin Bioscience Outstanding Ph.D. Thesis

Award Lectures

13:10 15:00 Break & Poster Viewing (Hall D2)15:00 15:30 Macrogen Scientist Award (Rm. 401) 15:30 16:00 Ilchun Memorial Lecture (Rm. 401)16:00 16:10 Break16:10 16:40 KSMCB Award for Women in Life Science Lecture (Rm. 401)16:40 17:20 Presidential Lecture Award (Rm. 401)17:20 18:00 KSMCB Life Science Award Lecture (Rm. 401)

18:00 18:30 Awards [M&C Award / Best Presentation Awards / Presentation Awards / Travel Grant Awards / Excellent Poster Awards &Closing Remarks (Rm. 401)]

▶ September 30 (Mon)

▶ October 1 (Tue)

▶ October 2 (Wed)

Welcome Reception for Principal Investigators Welcome Reception for Students/Postdoctoral Fellows


[ 3F ] Conference Room (Awards & Lectures, Symposia), Hall D2 (Exhibition, Poster Presentation)

[ 4F ] Conference Room (Plenary Lectures, Awards & Lectures, Symposia, Reception)

▶ Monday, September 30, 2019Session Time Place

1 Sym. 01 Cell Cycle and Genome Stability

09:30-11:30

Rm. 300

2 Sym. 02 Cilia in Development and Diseases Rm. 307

3 Sym. 03 Metabolic and Proteostatic Regulation of Aging and Age-associated Diseases Rm. 308

4 Sym. 04 Targeting Tumor & Tumor Microenvironment for Cancer Therapy Rm. 401

5 Sym. 05 Frontiers of Structural Biology Rm. 402

6 Global Network Session 11:30-13:00 Rm. 300

7 Opening Ceremony 13:00-13:20Rm. 401

8 Plenary Lecture I. David A. Agard, Ph.D. 13:20-14:10

9 Sym. 06 Plant Molecules in Motion

14:20-16:20

Rm. 300

10 Sym. 07 Forces in Cell Biology Rm. 307

11 Sym. 08 Gendered Innovation in Biomedical Research Rm. 308

12 Sym. 09 Using Light and Genetic Tools to Interrogate Neural Circuits Rm. 401

13 Sym. 10 New Technologies to Overcome Antimicrobial Resistance Rm. 402

14 Plenary Lecture II. Masashi Yanagisawa, M.D., Ph.D. 16:40-17:30 Rm. 401

Session Time Place

1 Sym. 11 Plant Immunity

09:10-11:10

Rm. 300

2 Sym. 12 Microbiome and Mouse Model Rm. 307

3 Sym. 13 New players in B cell-T cell interactions Rm. 308

4 Sym. 14 Epigenetics and Transcription Rm. 401

5 Sym. 15 RNA Biology Rm. 402

6 Plenary Lecture III. Yoshinori Ohsumi, M.D., Ph.D. 11:30-12:20 Rm. 401

5 AMOREPACIFIC Great Global Next Generation Research Award Lectures 12:20-13:35 Rm. 300

6 MERCK 350 Future Researcher Award Lectures12:20-13:10

Rm. 307

7 KSMCB Council Meeting Rm. 402

8 Plenary Lecture IV. Robert Huber, Ph.D. 15:00-15:50 Rm. 401

9 Sym. 16 AI & Data Driven Drug Discovery (AI-D4)

16:00-18:00

Rm. 300

10 Sym. 17 Dynamics and Traffic of Intracellular Membranes Rm. 307

11 Sym. 18 Generation of Cellular Diversity in Neural Development Rm. 308

12 Sym. 19 Molecular/Cellular Cancer Biology Rm. 401

13 Sym. 20 Circadian Clock in Physiology and Behavior Rm. 402

14 Welcome Reception 18:00-19:00 Rm. 401 Lobby

Session Time Place

1 Sym. 21 Bioactive Lipids in Health and Disease

09:10-11:10

Rm. 300

2 Sym. 22 Plant Genome Editing Rm. 307

3 Sym. 23 Immunometabolism Rm. 308

4 Sym. 24 Signal Transduction Rm. 401

5 Sym. 25 Brain Dysfunction and Infectious Disease Rm. 402

6 Plenary Lecture V. Li-Huei Tsai, Ph.D. 11:30-12:20 Rm. 401

7 Research Ethics Symposium (Korean)

12:20-13:10

Rm. 307

6 Takara Excellence Thesis Award Lectures Rm. 308

7 KSMCB General Assembly Rm. 401

8 SeouLin Bioscience Outstanding Ph.D. Thesis Award Lectures Rm. 402

9 Macrogen Scientist Award Lecture 15:00-15:30

Rm. 401

10 Ilchun Memorial Lecture 15:30-16:00

11 KSMCB Award for Women in Life Science Lecture 16:10-16:40

12 KSMCB Presidential Award Lecture 16:40-17:20

13 KSMCB Life Science Award Lecture 17:20-18:00

14 KSMCB M&C Award / Best Presentation Awards / Presentation Awards / KSMCB Travel Grant Awards / KSMCB Excellent Poster Awards & Closing Remarks 18:00-18:30

▶ Tuesday, October 01, 2019

▶ Wednesday, October 02, 2019



Call for Abstracts

✽ Deadline for Abstract Submission: August 16 (Fri), 2019.- Abstracts should be written in English.

- Abstracts should be submitted online.- Authors may further edit and modify submitted abstracts until the submission deadline. It is the responsibility of the authors to ensure that their text does not contain types or grammatical errors.- No proofreading will be carried out, and no correction will be possible after the submission deadline.

◎ Abstract Topics - Aging and Age-Related Diseases- Biochemistry, Structural Biology and Biophysics- Bioimaging and Biotechnology- Bioinformatics and Systems Biology- Cell and Tissue Architecture- Cell Cycle and Genome Stability- Cell Death and Autophagy- Development, Differentiation and Regeneration- Epigenetics and Transcription- Immunology and Immunological Diseases- Lipids, Membranes and Trafficking- Metabolism and Metabolic Diseases- Microbiology, Virology and Pathogens- Molecular and Cellular Neurobiology- Molecular Cancer Biology- Molecular Medicine- Plant Development and Physiology- Plant Stress Defense- RNA and Translation- Signal Transduction- Stem Cells- Systems Neuroscience- Tumor Microenvironment- Vascular Biology- Others- High School and Undergraduate Students’ Posters- Commercial Tutorials

◎ Poster Presentation Date & Place

KSMCB

Session Presentation Schedule Q&A (Stand by) Place

POSTER I 09:00-18:00, October 1, Tuesday 13:10-15:00 COEX 3F

Hall D2POSTER II 09:00-17:00, October 2, Wednesday 13:10-15:00


◎ General Guidelines for Poster Presentation1. Presenters should finish registration for the conference.2. Presenters will be asked to stand in front of their posters during the poster session. Especially, they need to be there within a specified window of time for the evaluation by referees.3. The preferred content of poster has abstract, purpose of experiment, results (figures, tables), conclusions, and

references.4. The messages should be clear and easy to understand without oral explanation.5. Please use tapes to attach your poster on the board. (Please bring your own tapes.); No pins or thumb tacks can

be used.6. Every poster has to be removed by presenters after their presentations.

◎ Guidelines for attaching a poster• The size of poster board provided is 100 cm wide and 250 cm high.• Please prepare a 10-30 cm high headline strip that runs the full width of the poster with the title, author(s), and

affiliation(s).• Please attach your poster 30-40 cm below the top of the poster board.



Awards

● Academic Research Awards [KSMCB Life Science Award / M&C Award]KSMCB Life Science Award is given to a member who is recognized for excellent research achievements in the fields of

molecular and cellular biology. The recipient delivers an award lecture at the annual meeting of KSMCB. KSMCB Molecules

and Cells Award is given to a member who has published the highly cited paper in Molecules and Cells, an official journal of

KSMCB, during the past three years.

● KSMCB Award for Women in Life ScienceThis award is given to outstanding research achievement in the fields of life science. The awardee gives a lecture at the annual

meeting of KSMCB in a special session. This award is supported by the donation of the former KSMCB president, Prof. Sang-

Dai Park who established our society in 1989.

● KSMCB Presidential Lecture AwardThis award is given to a distinguished scientist who has accomplished life-long outstanding research achievement and

contributions in the fields of life science. The awardee of the KSMCB Presidential Lecture Award gives a lecture as a keynote

speaker at the annual meeting of KSMCB. This award is supported by the donation of Prof. Hyen Sam Kang who served as the

president of KSMCB in 1993.

● Ilchun Memorial LectureThis lecture was named after the late Professor Ki-Nyung Lee (pen-named Ilchun), a pioneer of molecular biology in Korea, is

given to an eminent scientist from overseas. The awardee is asked to deliver a special lecture at the annual meeting of KSMCB.

● Macrogen Scientist AwardThis award is given to a scientist who has contributed substantially to the progress of molecular and cellular biology. The

awardee gives a lecture at the annual meeting of KSMCB in a special session. This award is sponsored by the Macrogen Co.

● Merck 350 Future Researcher Award This award is given to research faculty and postdoctoral fellows in the field of molecular and cellular biology. The awardee

must have conducted his or her research in a domestic institution and must be the first author of an excellent scientific

publication in the last three years. This award is sponsored by Merck Ltd.

● AMOREPACIFIC Great Global Next Generation Research AwardThis award is given to young research scientists including regular/temporary researchers, postdoctoral fellows, and graduate

students except principal investigator. Awardees must have performed their research in domestic institutions and been the

first authors of an excellent scientific publication within one year. This award is sponsored by AMOREPACIFIC Co.

● SeouLin Bioscience Outstanding Ph.D. Thesis AwardThis award is given to student members who have presented excellent doctoral dissertations of the year. This award is

sponsored by the SeouLin Bioscience Co.

● Takara Excellence Thesis AwardThis award is given to non-faculty research scientists including graduate students, postdoctoral research fellows, and regular/

temporary researchers. In order to be awarded, the candidate must publish his or her research as the first author in the

KSMCB


past two years, which should be performed in Korea and abroad. (1 awardee from each field which is 1) natural science 2)

biomedical science 3) agricultural/fisheries science) This award is sponsored by Takara Korea Biomedical Inc.

● Excellent Poster AwardEach year at the annual meeting since 1997, KSMCB has given poster awards to about 110 presenters who delivered the

best overall poster presentation. Extra point will be given to the candidates attending from the rural areas. These awards are

determined directly at the conference venue by the poster award evaluation committee.

● KSMCB Travel Grant Award 1. Eligibility(1) Graduate students and Post-Docs. who have applied to present a poster abroad.

(2) Applicants' name must be on the posters they present. If more than two applicants are in one poster, only one will be

funded.

2. Procedure(1) Complete a pre-registration and an online abstract submission.

(2) During the pre-registration, click a "Yes" button in the "Application for travel award" item and write the reason for

application in less 250 words.

(3) The deadline for application is August 16 (Fri), 2019.

(4) The Committee will review your application and abstract. The awards will be made by end of August, 2019.

(5) The Committee will support travel grants depending on the country and travel distance (USD 400).

(6) Travel awardees will be reimbursed for their pre-registration fee.

(7) The prize comprises a certificate. The certificates will be given on October 2 (Wed) during the Closing Remarks.

● KSMCB Young Investigator Research Awards1. Eligibility(1) Ph.D. students and postdoctoral fellows who have applied to present posters.

(2) Applicants' names must be on the posters they present. Only one person per poster is eligible for the award.

2. Procedure(1) Complete pre-registration and online abstract submission.

(2) During the online abstract submission click "Yes" radio button in the "Application for Oral Presentation" item.

(3) The deadline for application is August 16 (Fri), 2019.

(4) The Scientific Program Committee will review the abstracts. If you are selected as an "Oral Presenter", you will give an

oral presentation at a symposium session. Oral presentation time is 15 min (12 min presentation + 3 min Q&A). All the oral

presenters will receive Presentation Awards (certificate and KRW 100,000). These awards will be given on October 2 (Wed)

during the Closing Remarks.

• Above awards application forms are on the website, http://www.ksmcb.or.kr• Awards Application Deadline: July 31 (Wed), 2019



KSMCBGeneral Information

● Registration* Deadline for Pre-registration: August 16 (Fri), 2019.Participants are advised to register in advance (before August 16, 2019) to receive a pre-registration discount.Please read carefully the registration guidelines below.

● Registration Fee• Domestic

• Internatioanl

* Undergraduate Students and High School Students should submit their certificates of school registration on site.* Registration fees give the rights to participate in all the congress activities including scientific sessions, receptions,

exhibitions, and breaks.

● Hotel ReservationIt will be announced in June.

● SecretariatKorean Society for Molecular and Cellular Biology (KSMCB)Rm. 1105, The Korea Science and Technology Center, 22, 7 Gil, Teheran-ro, Gangnam-gu, Seoul 06130, KoreaTel: 82-2-568-4490 Fax: 82-2-558-0131E-mail: [email protected] URL: http://www.ksmcb.or.kr

Key Dates• Presentation Awards Application Deadline …………………………………………………………………………… July 30• Travel Awards Application Deadline ……………………………………………………………………………… August 16• Awards Application Deadline ………………………………………………………………………………………… July 31• Deadline for Hotel Reservation ……………………………………………………………………………………… August 23• Deadline for Pre-registration ………………………………………………………………………………………… August 16• Deadline for Abstract Submission …………………………………………………………………………………… August 16

ClassificationPre-Registration

(~August 16, 2019)

Non-Member USD 280

Student USD 120

ClassificationPre-Registration

(~August 16, 2019)On-site Registration

Member

Regular, Affiliate 150,000 200,000

Graduate Student 80,000 100,000

Undergraduate Student/High School Student

FREE FREE

Non-memberPI 270,000 330,000

Student 100,000 140,000


PL.Ⅰ

To Fold or not To Fold: the Yin and Yang ofChaperone-Mediated Client Activation

Plenary Lecture


Professor David A. Agard US biophysicist, David joined the faculty of the department of Biochemistry and Biophysics at the University of California, San Francisco in 1983. He is currently a Professor of Biochemistry & Biophysics, Professor of Pharmaceutical Chemistry, and an Investigator with the Howard Hughes Medical Institute. David was the founding Director of the California Institute for Bioengineering, Biotechnology and Quantitative Biomedical Research in 2001, and was its UCSF Scientific Director from 2002-2006. He received hisBS in Molecular Biophysics & Biochemistry from Yale in 1975 working with Fred Richards, and PhD in Biological Chemistry from the California Institute of Technology in 1980 working with Robert Stroud. This was followed by a brief postdoc with John Sedat at UCSF and his main postdoctoral work at the MRC Laboratory of Molecular Biology in Cambridge, England with Richard Henderson. Having a strong background in structural biophysics, David’s current work focuses on elucidating the mechanisms of assisted folding by the Hsp90 molecular chaperone system and the mechanism of microtubule nucleation. David has been instrumental in the development of direct phasing methods for

SAXS, three dimensional deconvolution and Structured Illumination light microscopies, automated cryo-electron tomography, the K2 Summit single electron counting direct detector, and second-generation beam-induced motion correction software. His work has been recognized by his election to the National Academy of Sciences in 2007 and American Academy of Arts and Sciences in 2009. Beyond numerous advisory boards, David served on the National Advisory General Medical Sciences Council at the NIH.

David A. Agard, Ph.D.University of California, San Francisco, USA

September 30 (Mon), 13:20-14:10, Rm. 401

• Organizer: Byoung Heon Kang, Ph.D. (Ulsan National Institute of Science and Technology (UNIST), Korea)• Chair: Byung-Ha Oh, Ph.D. (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Korea)


PL.Ⅱ

Toward the Mysteries of Sleep

Plenary Lecture

KSMCB

In 1988, as a graduate student at University of Tsukuba, Yanagisawa discovered endothelin, a potent vasoconstrictor peptide from vascular endothelial cells, which sparked an intense research activity in the field; his original paper has been cited 13,000 times by now. In the subsequent year, his group identified a receptor for endothelin, which would become an important drug target; the endothelin receptor antagonist bosentan was approved in 2001 for the treatment of pulmonary hypertension.

He was recruited to University of Texas Southwestern Medical Center at Dallas in 1991 as an HHMI Investigator. In 1996, he initiated a systematic search for endogenous ligands of “orphan” G protein-coupled receptors, which resulted in his 1998 discovery of orexin, a hypothalamic neuropeptide. He then discovered in 1999 that orexin deficiency causes the sleep disorder narcolepsy. This opened up a new avenue in sleep research, leading to better understanding of sleep/wake switching circuitry in the brain. The notion that orexin is an important endogenous waking agent led to the development of orexin receptor antagonists as sleep-

inducing drug, first of which, suvorexant, was approved in 2014.

Recognizing, however, that the fundamental mechanism for sleep homeostasis still remains a mystery, in 2010 he embarked upon a highly ambitious project of polysomnography (EEG/EMG)-based forward genetic screen for sleep/wake abnormalities in chemically mutagenized mouse cohort. This large-scale project is now continuing at the International Institute for Integrative Sleep Medicine (WPI-IIIS) in Tsukuba, Japan, and has recently led to identification of several new genes that are importantly involved in the regulation of sleep amounts and the level of sleep need.

Masashi Yanagisawa, M.D., Ph.D.University of Tsukuba, JAPAN

September 30 (Mon), 16:40-17:30, Rm. 401

• Organizer & Chair: Kyungjin Kim, Ph.D. (Deagu Gyeongbuk Institute of Science & Technology (DGIST), Korea)

Celebrating the 30th Anniversary


PL.Ⅲ

Looking Back on My 30 years' of YeastAutophagy Research

Plenary Lecture

Dr. Yoshinori Ohsumi was born in Fukuoka in 1945. In 1963, he entered to The Univ. of Tokyo. Since he met Prof. K. Imahori, he chose molecular biology as the path of his future. As a graduate student, Dr. Ohsumi studied E. coli ribosome and then colicin E3. Near the end of 1974, he enrolled in Rockefeller Univ., to study under Dr. G. M. Edelman. He returned to Japan at the end of 1977, and worked as an assistant professor under Prof. Y. Anraku at The Univ. of Tokyo. Dr. Ohsumi decided to take up the study of the yeast vacuolar membrane. He succeeded to show active transport systems and a novel proton-pump, v-type ATPase on the vacuolar membrane. In 1988, Dr. Ohsumi moved to College of Arts and Sciences of the same University as an associate prof., and opened up his own small lab. He started to work on the lytic function of the vacuole, then found yeast autophagy by light and electron microscopy. He performed a genetic screen for autophagy-defective mutants. His group got 18 genes essential for starvation-induced autophagy. Then he moved to The National Inst. for Basic Biology at Okazaki, and uncovered that these Atg proteins consist of several functional groups including two ubiquitin-like

conjugation systems. His colleagues started studies on ATG homologues in mammals and plant, proving that the ATG system is well conserved in higher eukaryotes. However, up to now, Dr. Ohsumi has focused on dissection of the mechanism of the Atg proteins in yeast at a molecular level. In 2009, he moved to Tokyo Inst. of Tech. and received the Nobel Prize in Physiology or Medicine for the elucidation of mechanisms for autophagy. He continues to elucidate the membrane dynamics and the physiological relevance of autophagy in the same university.

In addition to the research, he established the Ohsumi Frontier Science Foundation in 2016 for the development of basic science and he is working hard to the development of the basic science.

Yoshinori Ohsumi, M.D., Ph.D.Institute of Innovative Research(IIR), Tokyo Institute of Technology, JAPAN

*2016 Nobel Laureate

October 1 (Tue), 11:30-12:20, Rm. 401

• Organizer & Chair: Yong-Keun Jung, Ph.D. (Seoul National University, Korea)



PL.Ⅳ

The Century of Vision: Protein Structures in Basic Science and Pharma Research

Plenary Lecture

KSMCB

Robert Huber was born in 1937 in Munich. He studied chemistry at the Technische Universität München (TUM), where he also completed his Ph.D. and habilitation. Since 1972, he has been a member of the Max-Planck-Gesellschaft and Director at the Max-Planck-Institut für Biochemie until his retirement in 2005. Since 1976, he also serves at the TUM as a Professor. He holds appointments as Guest Professor at the Universität Duisburg-Essen (Germany), the Cardiff University

(Great Britain), the Universidad Autonoma de Barcelona (Spain), and the Seoul National University (Korea). He serves as a member of the Board and/or Scientific Advisory Board of a number of pharmaceutical and crop science companies, and he is co-founder of two companies, Proteros and Suppremol, located in Martinsried and offering services for drug discovery and development and for the development of novel therapies for autoimmune diseases, respectively. Huber has made major contributions to the understanding of the structure and function of biological macromolecules. He has studied proteases and their natural and synthetic inhibitors, metalloenzymes (iron, nickel,

molybdenum, copper), proteins of the immune system (antibodies and antibody receptors), protein hormones and their receptors, protein kinases, enzymes of amino acid biosynthesis, enzymes of cofactor and vitamin biosynthesis and proteins of energy and electron transfer. In addition, he has contributed to the development of instruments for data collection and to methods in protein crystallography, particularly Patterson methods, graphic methods, and refinement, to the use of electron rich metal clusters, and most recently to the methods and instruments for crystal improvement. He has been honoured by numerous honorary doctorates, professorships, memberships in learned societies and awards, including the Otto-Warburg Medal, the Emil von Behring Medal, the Sir Hans Krebs Medal, the The Linus Pauling Medal, Max Tishler Prize and, in 1988, the Nobel Prize for Chemistry together with H. Michel and J. Deisenhofer.

Robert Huber, Ph.D.Max Planck Institute of Biochemistry, Germany

*1988 Nobel Laureate

October 1 (Tue), 15:00-15:50, Rm. 401

• Organizer: Hyun Kyu Song, Ph.D. (Korea University, Korea), Jeong-Sun Kim, Ph.D. (Chonnam National University, Korea)• Chair: Chin Ha Chung, Ph.D. (Seoul National University, Korea)



PL.Ⅴ

Leveraging Brain Rhythms as a Therapeutic Intervention for Alzheimer's Disease

Plenary Lecture

Li-Huei Tsai is the Director of the Picower Institute for Learning and Memory at the Massachusetts Institute of Technology, a Picower Professor of Neuroscience, and an Associate Member of the Broad Institute. Tsai is a Fellow of the American Association for the Advancement of Science, a member of the National Academy of Medicine, and an Academician of the Academia Sinica in Taiwan.

Tsai is interested in elucidating the pathogenic mechanisms underlying neurological disorders that impact learning and memory. she is a recipient of the Mika Salpeter Lifetime Achievement Award, and the 2018 Hans Wigzell Research Foundation Science Prize for her research on Alzheimer’s disease.

Li-Huei Tsai, Ph.D.Massachusetts Institute of Technology, USA

October 2 (Wed), 11:30-12:20, Rm. 401

• Organizers: Sang Ki Park, Ph.D. (Pohang University of Science and Technology (POSTECH), Korea) Jinsoo Seo, Ph.D. (Deagu Gyeongbuk Institute of Science & Technology (DGIST), Korea)• Chair: Bong-Kiun Kaang, Ph.D. (Seoul National University, Korea)



Sym. 01 Cell Cycle and Genome Stability

Symposia

KSMCB

September 30 (Mon), 09:30-11:30, Rm. 300

Genome integrity is achieved by the action of multiple DNA damage sensors and effectors which are responsible for recognizing and correcting unintended insults in DNA. Mis-regulation of these pathways leads to deleterious mutations, which eventually result in diseases such as cancer and premature aging. Proper regulation of the cell cycle and cell's ability to execute proper checkpoint in response to DNA damage are crucial for preventing occurrence of DNA damage and development of diseases

associated with genomic instability. Thus, understanding molecular mechanisms underlying precise cell cycle regulation and preservation of genome integrity could unveil mechanisms of aforementioned diseases, furthermore novel insights into better therapies. In this symposium, speakers will cover nobel findings on key players in DNA damage response and cell cycle regulation. And cutting edge technologies to investigate DNA damage response will be introduced and discussed as well.

Organizer & Chair : Hongtae Kim, Ph.D. (School of Life Science, Ulsan National Institute of Science and Technology (UNIST), Korea)

BRCA1, BRCA2, and PALB2 protect transcriptional response to estrogens from 'abortive' catalysis by Topoisomerase II

Shunichi Takeda, Ph.D.Kyoto University, Japan

Damage search mechanism: find a needlein a haystick

Ja Yil Lee, Ph.D.Ulsan National Institute of Science andTechnology (UNIST), Korea

Study of DNA repair and replication using zebrafish model system

Yoonsung Lee, Ph.D.Institute for Basic Science (IBS), Korea

Kinetochores accelerate of delay APC/C activation by directing Cdc20 to opposing fates

Taekyung Kim, Ph.D.Department of Biological Sciences,Pusan National University, Korea

Young Investigator

Sym. 01-1

Sym. 01-2

Sym. 01-3

Sym. 01-4

Sym. 01-5

09:30-09:55

09:55-10:15

10:15-10:35

10:35-10:55

10:55-11:10



September 30 (Mon), 09:30-11:30, Rm. 307

Sym. 02 Cilia in Development and Diseases

Symposia

Cilia are organelles that extend from the surface of most mammalian cells. Cilia are of profound medical importance. When ciliary functions are disturbed, various human diseases such as kidney cysts, cancer, retinal degeneration, and obesity are induced. The understanding of cilia has increased in depth and breadth as we learn more about these remarkable organelles. This session will cover basic topics in ciliary structure/

transport, ciliary dynamics and signaling, cilia in the nervous system, and human ciliopathies. This session is organized by the Cilia and flagella section of The Korean Society for Molecular and Cellular Biology and will bring together basic scientists and clinicians, resulting in crosstalk, collaborations, and innovative new directions.

Organizer & Chair : Ji Eun Lee, Ph.D. (Department of Health Sciences & Technology, Sungkyunkwan University, Korea)

The effect of cytokinesis failure in the differentiation of renal fibroblasts in CKD progression

Sang Ho Lee, M.D., Ph.D.Department of Nephrology, College of Medicine, Kyung Hee University, Korea

Metalloproteinases of ADAMTS familyregulate primary cilia

Heon Yung Gee, M.D., Ph.D.Department of Pharmacology, College of Medicine, Yonsei University, Korea

TBABryan Tsou, Ph.DMemorial Sloan Kettering Cancer Center, USA

Complexity of ciliogenesis programs in mouse development

Hyuk Wan Ko, Ph.DDepartment of Biochemistry, Yonsei University, Korea

Young Investigator

Sym. 02-1

Sym. 02-2

Sym. 02-3

Sym. 02-4

Sym. 02-5

09:30-09:50

09:50-10:10

10:10-10:50

10:50-11:15

11:15-11:30



Sym. 03 Metabolic and Proteostatic Regulation of Aging andAge-associated Diseases

Symposia

KSMCB

September 30 (Mon), 09:30-11:30, Rm. 308

Metabolism and proteostasis play central roles in aging and age-associated pathology. In this symposium, excellent scientists will present their research on mechanisms by which metabolic and proteostatic aspects contribute to aging processes and age-related diseases at the cellular and organismal levels. Thorsten Hoppe, a world leader in the aging research field, will give a talk regarding how selective protein turnover delays organismal aging. Three leading scientists in Korea will

then present their recent work on metabolism and Alzheimer’s disease (Inhee Mook-Jung), autophagy and cellular senescence (Chanhee Kang), and longevity and organelle communication (Seung-Jae V. Lee), followed by a young investigator’s talk. Overall this symposium will cover exciting progresses in the regulation of aging by metabolism and protein homeostasis, which is crucial for human health in this aged society.

Organizer & Chair : Seung-Jae V. Lee, Ph.D. (College of Life Science and Bioengineering, Korea Advanced Institute of Science and Technology (KAIST), Korea)

Ubiquitin sets the timer: Coordination of Protein homeostasis & Aging

Thorsten Hoppe, Ph.D.University of Cologne, Germany

Metabolic reprogramming of microglia in Alzheimer's Disease

Inhee Mook-Jung, Ph.D.College of Medicine, Seoul National University, Korea

Selective Autophagy Networks during Cellular Senescence

Chanhee Kang, Ph.D.School of Biological Sciences, Seoul National University, Korea

Regulation of cold-induced longevity by lipid metabolism

Seung-Jae V. Lee, Ph.D.Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Korea

Young Investigator

Sym. 03-1

Sym. 03-2

Sym. 03-3

Sym. 03-4

Sym. 03-5

09:30-10:00

10:00-10:25

10:25-10:50

10:50-11:15

11:15-11:30



September 30 (Mon), 09:30-11:30, Rm. 401

Sym. 04 Targeting Tumor & Tumor Microenvironmentfor Cancer Therapy

Symposia

This session compose: (I) immunoediting in cancer cells & tumor microenvironment(TME), (ii) exosomes secreted by cancer cells, (III) response from neighbor stromal cells (fibroblasts), (IV) understanding of the NK cell therapy and (V) Jens project. The tumor microenvironment is a heterogeneous tissue that in addition to tumor cells, contain tumor-associated cell types such as immune cells, fibroblasts, and endothelial cells. Tumor growth creates hypoxia, oxidative stress and acidosis within the TME triggering an adjustment of the extracellular matrix (ECM), a response from neighbor stromal cells (e.g., fibroblasts) and immune cells (lymphocytes

and macrophages), inducing angiogenesis and, ultimately, resulting in metastasis. Exosomes secreted by tumor or TME cells are central players in all these events. Some new therapeutic options that include drugs targeting microenvironment components are achieving encouraging results in reducing the number of tumors and/or overcoming their resistance in preclinical studies. And also, increased understanding of the NK cell response to TME has provided a better understanding of their impaired function in tumors which may aid in the development of novel immunotherapeutic strategies to enhance NK cell responses in cancer patients.

Organizers and Chairs : Sang-Kyu Ye, Ph.D. (College of Medicine, Seoul National University, Korea), Yong-Nyun Kim, Ph.D. (National Cancer Center, Korea)

NANOG drives a multi-malignant evolution of tumor cells during immunoediting

Tae Woo Kim , Ph.D.Department of Biochemistry & Molecular Biology and Department of Biomedical Science, Korea University College of Medicine, Korea

The secretion inhibition of small extracellular vesicles by targeting the endothelin receptor A

Moon-Chang Baek, Ph.D.Department of Molecular Medicine, Kyungpook National University School of Medicine, Korea

Reactivation of embryo-morphogenic program in cancer-associated fibroblast of advanced cancer

Seok-Hyung Kim, M.D., Ph.D.Department of pathology, Samsung medical center, College of medicine, Sungkyunkwan University Korea

Development of Next Generation Cellular Immune-oncology Drug

Yu-Kyeong HwangCell Therapy Research Center, GC LabCell

Young Investigator

Sym. 04-1

Sym. 04-2

Sym. 04-3

Sym. 04-4

Sym. 04-5

Sym. 04-6

09:10-09:35

10:55-11:10

09:35-09:55

09:55-10:15

10:15-10:35

10:35-10:55



Sym. 05 Frontiers of Structural Biology

Symposia

KSMCB

September 30 (Mon), 09:30-11:30, Rm. 402

The knowledge gained from structural studies of biomolecules including protein, DNA/RNA and their complex, have significantly advanced our understanding on biological phenomena at the molecular level and contributed to the development of therapeutics. Recently, cryo-electron microscopy (Cryo-EM) highlighted as the powerful technique to investigate stuctural information of macromolecular complexes as well as membrane proteins. Particularly, resolution revolution in single particle Cryo-EM have been led by technical breakthroughs such as direct electron detector (DED) with unprecedented speed and sensitivity, a state of the art electron microscope, efficient image processing software with better algorithms

and GPG-based parallel computation, resulting in a burst of high-resolution structures of large macromolecular assemblies and membrane protein. Another technique for structural biology, high-speed atomic force microscopy (HS-AFM), is also evolving rapidly, which allow us to monitor the sturctural changes of protein with a high spatial and temporal resolution (< 1 nm, 50ms) in a liquid phase. These achievements herald the beginning of a new era in the field of structural biology. In this session, we are going to discuss about current progress in frontier techniques for structural biology.

Organizer & Chair : Ho Min Kim, Ph.D. (Korea Advanced Institute of Science and Technology (KAIST), Korea)

Atomic Resolution CryoEM for Future Large-scale Applications

Xueming Li, Ph.D.Tsinghua University, China

Functional and Structural dissection reveals Principles of TRiC-PFD cooperation

Soung-Hun Roh, Ph.D.School of Biological Science, Seoul National University, Korea

Strucure of human GLC3 gap junction hemichannelJae Sung Woo, Ph.D.Department of Life Sciences, Korea University, Korea

Structural study on prokaryotic transcription - how RNA polymerases pauses and go

Jin Young Kang, Ph.D.Korea Advanced Institute of Science andTechnology (KAIST), Korea

AFM imaging of condensin-mediated DNA loop extrusion

Je-Kyung Ryu, Ph.D.TU Delft in the Netherlands, Korea

Young Investigator

Sym. 05-1

Sym. 05-2

Sym. 05-3

Sym. 05-4

Sym. 05-5

Sym. 05-6

09:30-10:00

10:00-10:20

10:20-10:40

10:40-11:00

11:00-11:15

11:15-11:30



September 30 (Mon), 14:20-16:20, Rm. 300

Sym. 06 Plant Molecules in Motion

Symposia

Communication among cells is an essential part of life in multicellular organisms; plants are no exception. However, the encapsulation of plant cells by cell walls and the lack of an active circulatory system poses a question on how signaling molecules are transmitted between cells in plants. Nevertheless, ample examples indicate that many molecules

including proteins and RNAs move a long distance to regulate various aspects of plant development. This session will highlight the recent progress made on the movement of plant molecules, including small molecules, RNAs and proteins through specific transporters and plasmodesmata.

Organizer & Chair : Giltsu Choi, Ph.D. (Korea Advanced Institute of Science and Technology (KAIST), Korea)

Inter-organ communication by plant mobile mRNAs

Tien-Shin Yu, Ph.D.Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan

Florigen is on the way (Interaction between FLOWERING LOCUS T and membrane phospholipid)

Ji Hoon Ahn, Ph.D.Division of Life Sciences, Korea University, Korea

Callose-mediated regulation of intercellular symplasmic channels, plasmodesmata

Jae-Yean Kim, Ph.D.Gyeongsang National University, Korea

A multitude of ACC transporters in Arabidopsis thaliana

Su-Min Lee, Ph.D.Department of Integrative Bioscience and Biotechnology, College of Life Science, Sejong University, Korea

Young Investigator

Sym. 06-1

Sym. 06-2

Sym. 06-3

Sym. 06-4

Sym. 06-5

14:20-14-45

14:45-15:10

15:10-15:35

15:35-16:00

16:00-16:20



Sym. 07 Forces in Cell Biology

Symposia

KSMCB

September 30 (Mon), 14:20-16:20, Rm. 307

This symposium, titled "Forces in Cell Biology," deals with new engineering approaches to understand cells. Cellular physiology is regulated by complex physicochemical cues from tissue microenvironments. Despite the importance of physical factors in cellular physiology and pathology, the current focus of medicine largely ignores the physical basis of the diseases. Mechanobiology is an interdisciplinary field that combines classical mechanics with molecular and cellular biology as well as genetics to

address the importance of mechanical stresses in the disease development through accessing biophysical properties of the cells and cellular components. Re-evaluation of human pathophysiology in the context of mechanobiology may provide researchers with a unique opportunity to identify biophysical markers or targets for disease detection, diagnosis, and therapeutics. The speakers of this symposium will introduce the latest research trends in the field of cell mechanics and mechanobiology.

Organizer & Chair : Jennifer Hyunjong Shin, Ph.D. (Korea Advanced Institute of Science and Technology (KAIST), Korea)

Mechanobiology of Collective Cell MigrationChwee Teck Lim, Ph.D.National University of Singapore, Singapore

Nuclear mechanobiology: Biological interpretation of nuclear mechanics

Dong-Hwee Kim, Ph.D.KU-KIST Graduate School of Converging Science and Technology, Korea University, Korea

Shining a light on phase separation in living cellsYong Dae Shin, Ph.D.Department of Mechanical and Aerospace Engineering, Interdisciplinary Program for Bioengineering, Seoul National University, Korea

Evolution of Mechanical Stresses during Cell Migration

Jennifer Hyunjong Shin, Ph.D.Korea Advanced Institute of Science and Technology (KAIST), Korea

Young Investigator

Sym. 07-1

Sym. 07-2

Sym. 07-3

Sym. 07-4

Sym. 07-5

14:20-15:00

15:00-15:20

15:20-15:40

15:40-16:00

16:00-16:20



September 30 (Mon), 14:20-16:20, Rm. 308

Sym. 08 Gendered Innovations in Biomedical Research

Symposia

Even though we know that male and female are not the same, experimental results obtained from research using only one sex are sometimes extrapolated to both sexes without through justification. These kinds of inadvertent extrapolation might cause harmful results and economic loss. Recently, renowned funding organizations such as the European Commission, the Canadian Institutes of Health Research, and the US National Institutes of Health try to influence researchers to integrate sex/gender not only in clinical research but also in basic and

preclinical research. Editorial policies of major scientific journals have been changed and ask authors to consider integrating sex as a biological variable. We invited four distinguished scholars who will share their findings/efforts to integrated sex/gender in biomedical research. We expect this symposium will heighten interests and broaden understanding regarding sex as an important biological variable from basic and preclinical research.

Organizer & Chair : Suk Kyeong Lee, Ph.D. (School of Medicine, The Catholic University of Korea, Korea)

Overview of developments to integrate sex and gender analysis into preclinical, clinical, and population health research

Ineke Klinge, Ph.D.Maastricht University, Netherland

Sex as an important biological variable in cell experiments

Suk Kyeong Lee, Ph.D.Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Korea

Diet-Gene Interactions in Obesity and their Sex Differences

Mi-Kyung Sung, Ph.D.Department of Food and Nutrition, Sookmyung Women's University, Korea

Gendered Innovations Research and Editing Scholarly Journal

Sung Tae Hong, Ph.D.Seoul National University, Korea

Young Investigator

Sym. 08-1

Sym. 08-2

Sym. 08-3

Sym. 08-4

Sym. 08-5

14:20-15:00

15:00-15:20

15:20-15:40

15:40-16:00

16:00-16:20



Sym. 09 Using Light and Genetic Tools to InterrogateNeural Circuits

Symposia

KSMCB

September 30 (Mon), 14:20-16:20, Rm. 401

Optogenetic techniques, broadly defined as methods that combine the usage of light and light-sensitive actuators and reporters, have revolutionized the investigation of neural circuits. New optical tools are continuously being developed to accelerate experiments with unprecedented temporal and spatial resolution, while rapidly developing genetic strategies and single-cell sequencing techniques facilitate precision targeting of specific cell types. These tools are unveiling

previously unforeseen structure and function of the neural circuits in both peripheral and central nervous system. With the aim of introducing the latest optogenetic tools and their applications in dissecting the functional anatomy of the neural circuitry, we will bring together a number of experts in the field, who are actively applying these tools to deepen our understanding of a wide range of neural circuits-from simple sensory modalities to complex behavioural states.

Organizers & Chairs : Jaewon Ko, Ph.D. (Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Korea) Sung-Yon Kim, Ph.D. (Department of Chemistry, Institute of Molecular Biology and Genetics, Seoul National University, Korea)

Optical microscopy and computation for analyzing brain functions

Young-Gyu Yoon, Ph.D.Korea Advanced Institute of Science and Technology (KAIST), Korea

Differential roles of basal ganglia ouputs inaction generation

Jeongjin Kim, Ph.D.Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (KIST), Korea

A neural circuit mechanism for monitoring and controlling ingestion

Sung-Yon Kim, Ph.D.Department of Chemistry, Institute of Molecular Biology and Genetics, Seoul National University, Korea

Rapid signaling along the gut-brain axis regulates homeostatic hunger circuits

Nicholas Betley, Ph.D.University of Pennsylvania, USA

Young Investigator

Sym. 09-1

Sym. 09-2

Sym. 09-3

Sym. 09-4

Sym. 09-5

14:20-14:45

14:45-15:10

15:10-15:35

15:35-16:05

16:05-16:20



September 30 (Mon), 14:20-16:20, Rm. 402

Sym. 10 New Technologies to Overcome Antimicrobial Resistance

Symposia

Increasing incidences of antimicrobial resistance (AMR) in pathogenic bacteria are a global health concern. Thus, more and more attention will be paid to the adoption and improvement of rapid diagnostic and alternative therapeutic strategies to address the concerns regarding AMR. Application of state-of-the-art omics technologies combined with bioinformatics tools will facilitate the development of new technological platforms to detect and mitigate AMR. The topics discussed in this session will include a new method for AMR detection and new insights into

antibacterial discovery and development based on the model host screens, bacterial vulnerable targets, or bacterial predatorsed engineering, which can be translated to clinically achievable diagnostics and therapeutics.

Organizer & Chair : You-Hee Cho, Ph.D. (CHA University, Korea)

A novel loop-mediated isothermal amplification method detecting the Guiana extended-spectrum (GES) type β-lactamase gene of Pseudomonas aeruginosa

Mitsuko Seki, Ph.D.Meikai University, Japan

Diagnosis and combi-therapy against super-bacteria

Choong-Min Ryu, Ph.D.Infectious Disease Research Center, Korea Research Institute of Bioscience & Biotechnology, Korea

Understanding microbial response to antibiotics through genomics and chemical biology

Wonsik Lee, Ph.D.Sungkyunkwan University, Korea

Genetic engineering of Vibrio cholerae strainsDong Wook Kim, Ph.DHanyang University, Korea

Young Investigator

Sym. 10-1

Sym. 10-2

Sym. 10-3

Sym. 10-4

Sym. 10-5

14:20-14:45

14:45-15:10

15:10-15:35

15:35-16:00

16:00-16:20



Sym. 11 Plant Immunity

Symposia

KSMCB

October 1 (Tue), 09:10-11:10, Rm. 300

Pathogen effector recognition by plant NLR immune receptors and decoy domains

Thomas Kroj, Ph.D.National Institute of Agronomic Research (INRA), France

Serine proteases as both virulence factors and immunity elicitors of Gram-positive pathogenic bacteria in plants

Chang-Sik Oh, Ph.D.Department of Horticultural Biotechnology, Kyung Hee University, Korea

Bacterial effectors as probes for plant immunityand development

Cecile Segonzac, Ph.D.Seoul National University, Korea

Dynamic inter-organellar communication in plant-microbe interaction

Eunsook Park, Ph.D.Department of Molecular Biology, College of Agricultural and Natural Resources, University of Wyoming, Korea

Young Investigator

Sym. 11-1

Sym. 11-2

Sym. 11-3

Sym. 11-4

Sym. 11-5

09:10-09:50

09:50-10:10

10:10-10:30

10:30-10:50

10:50-11:10

Plants defend against invading pathogens by activating innate immune system. In turn, successful pathogens suppress host immunity by delivering virulence proteins into plant cell during infection. These virulence proteins, termed ‘effectors’, biochemically modify host cell target proteins and affect various aspects of plant immunity, physiology and development hence promoting infection. In disease resistant plants, NLR (nucleotide-binding and leucine rich repeat) immune receptors confer recognition of one or more of pathogen effectors and activate effector-triggered immunity (ETI).

At the plant immunity session of KSMCB 2019, the most recent progress on our understanding of the molecular mechanisms of plant immune system will be introduced by internationally recognized scientists. Presentations at the plant immunity session will include molecular genetics, cell biology and structural studies of different model systems of the plant-pathogen interactions.

Organizer & Chair : Kee Hoon Sohn, Ph.D. (Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Korea)



October 1 (Tue), 09:10-11:10, Rm. 307

Sym. 12 Microbiome and Mouse Model

Symposia

The secretion of exosomes known as extracellular vesicles is an evolutionarily conserved cellular process occurring from simple organisms to complex multicellular organisms. Recent progress in this area has revealed that exosomes play multiple roles in intercellular and interkingdom communication, suggesting that exosomes are NanoCosmos, i.e., extracellular organelles that play diverse roles in

intercellular communication. This session will highlight emerging exosome biology covering from concept of exosome-mediated intercellular communication, comprehensive aspects of exosomes including components, biogenesis, and diverse functions that should facilitate further applications, especially to develop diagnostic tools and therapeutics.

Organizer & Chair : Je Kyung Seong, Ph.D. (Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Seoul National University, Korea)

Understanding the variability of the faecalmicrobiota in mice

Guillaume PavlovicGenetic Engineering and Model Validation Department - Institut Clinique de la Souris - PHENOMIN, France

Analysis of the metagenome and metatranscriptom in the mouse gut

Ji-Hwan Ryu, Ph.DSeverance Biomedical Science Institute, College of Medicine, Yonsei University, Korea

Bacterial infection control enabled by neighboring symbionts

Sang Sun Yoon, Ph.DDepartment of Microbiology and Immunology, College of Medicine, Yonsei University, Korea

How to Develop ImmunoregulatoryPharmabiotics Using a Mouse Model?

Sin-Hyeog Im, Ph.DDivision of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology (POSTECH), Korea

Young Investigator

Sym. 12-1

Sym. 12-2

Sym. 12-3

Sym. 12-4

Sym. 12-5

09:10-09:35

09:35-10:00

10:00-10:25

10:25-10:50

10:50-11:10



Sym. 13 New players in B cell-T cell interactions

Symposia

KSMCB

October 1 (Tue), 09:10-11:10, Rm. 308

Transcriptional regulation of Tfh differentiationYoun Soo Choi, Ph.D.College of Medicine, Seoul National University, Korea

Tfc cells: the cytotoxic dancer in the hall of Bcell follicle

Di Yu, Ph.D.Department of Immunology and Infectious Diseases, Australian National University, Austrailia

Regulation of Tfh1 cell differentiationby CIC-ETV5 axis

Yoontae Lee, Ph.D.Pohang University of Science and Technology (POSTECH), Korea

A subpopulation of Tfh cell promote Tfr cell generation through sostdc1

Xindong Liu, Ph.D.Institute of Pathology and Southwest Cancer Center, Third Military Medical University, China

Young Investigator

Sym. 13-1

Sym. 13-2

Sym. 13-3

Sym. 13-4

Sym. 13-5

09:10-09:35

09:35-10:00

10:00-10:25

10:25-10:50

10:50-11:00

Humoral responses are key in vaccine development but also act as pathogenic mechanism in autoimmune diseases and allergy. B cell-T cell interactions bring about the maturation and production of high affinity antibodies and are key to the establishment of effective humoral immunity. There is a significant advance in our understanding of how B cell-T cell interactions drive antibody affinity maturation in last two decades with the discovery of Tfh cells and Tfr cells as key regulators of germinal center

reactions. Nevertheless, a number of scientific questions are yet unclear, including how these interactions influence the differentiation of B cells into effector fates and how they limit the emergence of autoreactive B cell clones. In this symposium, we aim to present the most recent advances in the basic biology of the T cell-dependent B cell responses, and to discuss how furthering our understanding of B cell-T cell interactions can inform vaccine development as well as allergy and autoimmunity.

Organizer & Chair : Yeonseok Chung, Ph.D. (College of Pharmacy, Seoul National University, Korea)



October 1 (Tue), 09:10-11:10, Rm. 401

Sym. 14 Epigenetics and Transcription

Symposia

Chromatin structure and its epigenetic regulation control transcriptional outcome. Therefore, temporal and spatial regulation of chromatin structure and transcription is a key to the normal development and physiology. Accordingly, deregulated chromatin modifications and transcription are associated with developmental defects as well as other disease states.

In this session, five excellent scientists will discuss current understanding of chromatin and transcription in development and diseases. The topics include the function of chromatin architecture and chromatin-associated proteins in developmental process, cancer and neurodegenerative disease such as Parkinson's disease.

Organizer & Chair : Daeyoup Lee, Ph.D. (Korea Advanced Institute of Science and Technology (KAIST), Korea)

Epigenomic regulation of non-coding DNA in development and diseases

Danny Chi Yeu Leung, Ph.D.Hong kong University of Science and Technology (HKUST), Hong Kong

The epigenetic tole of Ctbp in silencing of active genes for ESC to exit from pluripotency

Hong Duck Yoon, Ph.D.Seoul National University, Korea

Functional coordination between BET family proteins in the brain

Tae-Kyung Kim, Ph.D.Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Korea

Dysregulation of Chromatin Architecture in Complex Human Disease

Inkyung Jung, Ph.D.Korea Advanced Institute of Science and Technology (KAIST), Korea

Young Investigator

Sym. 14-1

Sym. 14-2

Sym. 14-3

Sym. 14-4

Sym. 14-5

09:10-09:40

09:40-10:05

10:05-10:25

10:25-10:45

10:45-11:10



Sym. 15 RNA Biology

Symposia

KSMCB

October 1 (Tue), 09:10-11:10, Rm. 402

Regulation of Cellular Senescence by Noncoding RNPs

Myriam Gorospe, Ph.D.National Institute on Aging (NIA), National Institutes of Health (NIH), USA

A novel mechanism mediated by a non-coding RNA, nc886, in the cytotoxicity of a DNA-reactive compound

Yong Sun Lee, Ph.D.Graduate School of Cancer Science and Policy, National Cancer Center, Korea

A Neuronal piRNA pathway in Axon RegenerationKyung Won Kim, Ph.D.Hallym University, Korea

Epitranscriptomics: The new insights into the gene expression regulation through RNA Modification

Junho Choe, Ph.D.Hanyang University, Korea

Young Investigator

Sym. 15-1

Sym. 15-2

Sym. 15-3

Sym. 15-4

Sym. 15-5

09:10-09:40

09:40-10:05

10:05-10:30

10:30-10:55

10:55-11:10

RNA biology research has become a rapidly expanding field to explore regulatory RNAs, RNA metabolisms, and the roles of non-coding RNAs in diverse cellular progresses such as cellular senecence, tumorigenesis, differentiation, and development. Recent advances in high-throughput RNA sequencing have facilitated the discovery of new principles and

mechanisms of RNA-mediated gene regulation. This symposium highlights not only the regulatory mechanisms orchestrated by diverse types of RNA but also their potential applications, and speakers will present their fascinating achievements to uncover new mechanisms of gene expression at RNA levels.

Organizers & Chairs : Dong-Eun Kim, Ph.D. (Konkuk University, Korea), Eun Kyung Lee, Ph.D (Catholic University of Korea, Korea)



October 1 (Tue), 16:00-18:00, Rm. 300

Sym. 16 AI & Data Driven Drug Discovery (AI-D4)

Symposia

Application of "Big Data and Artificial Intelligence (AI)" to innovative drug discovery has inspired both academia and phamaceutical industry over the last years. Since the success of AlphaGO, these initial expectations are getting realistic as demonstrated by AlphaFold (Science 2018) in protein folding prediction - one of the most challenging problems for decades. Drug discovery & development is getting more of an information

science than the past, where computational analyses often play a critical role such as cheminfomatics, bioinformatics, data mining or machine learning including recently highlighted deep neural network (DNN). In this symposium, five speakers are invited to present their on-going studites in the emerging field of AI of Data-Driven Drug Discovery (D4).

Organizer & Chair : Wankyu Kim, Ph.D (Ewha Womans University, Korea)

Improving cancer chemotherapy withstructure-based drug repositioning

Michael Schroeder, Ph.D.Technische Universität Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Germany

AI-based Drug Prediction Platform Construction on Korea Chemical Bank

Keun Woo Lee, Ph.D.Division of Applied Life Science, Gyeongsang National University, Korea

AI-based drug candidate predictionHojung Nam, Ph.D.Gwangju Institute of Science and Technology (GIST), Korea

Data Driven Drug Discovery for CancerPrecision Medicine

Wankyu Kim, Ph.D.Department of Life Sciences, Ewha Womans University, Korea

Young Investigator

Sym. 16-1

Sym. 16-2

Sym. 16-3

Sym. 16-4

Sym. 16-5

16:00-16:25

16:25-16:50

16:50-17:15

17:15-17:40

17:40-17:55



Sym. 17 Dynamics and Traffic of Intracellular Membranes

Symposia

KSMCB

October 1 (Tue), 16:00-18:00, Rm. 307

Lipid droplets and peroxisomes remain associated with ER subdomains where they form

William Prinz, Ph.D.National Institute on Aging (NIA), National Institute of Diabetes and Digestive and Kidney (NIDDK), USA

Reconstruction of the mechano-chemical circuit governing Ca2+-triggered neuronal exocytosis

Tae-Young Yoon, Ph.D.School of Biological Sciences, Seoul National University, Korea

COPI vesicle fission is promoted by short formsof key lipids

Seung-yeol Park, Ph.D.Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Korea

Novel roles of mitochondria and ER for synaptic function and development through regulation of Ca2+ homeostasis

Seok-Kyu Kwon, Ph.D.Center for Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology (KIST), Korea

Young Investigator

Sym. 17-1

Sym. 17-2

Sym. 17-3

Sym. 17-4

Sym. 17-5

16:00-16:40

16:40-17:05

17:05-17:25

17:25-17:45

17:45-18:00

Vesicular transport shuttles membrane-bound carriers among the different intracellular organelles. It is fundamental cellular process, as properly localized cargoes (proteins and lipids) are essential to perform their function. In addition to classical vesicular transport, recent studies have also proposed non-vesicular transport, mediated by physical membrane contact between intracellular organelles. Indeed, there is now

a growing list of diseases and pathologic conditions that are caused or exacerbated by alterations in mechanisms of membrane trafficking. This session will introduce the latest research and cutting-edge approaches to membrane dynamics, intracellular trafficking, and organelle communication.

Organizer & Chair : Joo-Yeon Yoo, Ph.D. (Pohang University of Science and Technology (POSTECH), Korea)



October 1 (Tue), 16:00-18:00, Rm. 308

Sym. 18 Generation of Cellular Diversity in Neural Development

Symposia

Generating neuronal diversity in humanretinal organoids

Robert J. Johnston Jr, Ph.D.Department of Biology, Johns Hopkins University, USA

Commitment Matters: Timely and Robust Cell Fate Specification in Neural Stem cell Lineages

Yan Song, Ph.D.School of Life Sciences, Peking University, China

Deciphering neural epitranscriptome in the developing brain

Ki-Jun Yoon, Ph.D.Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Korea

Single cell heterogeneity underlies pluripotencyJiwon Jang, Ph.D.Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Korea

Young Investigator

Sym. 18-1

Sym. 18-2

Sym. 18-3

Sym. 18-4

Sym. 18-5

16:00-16:30

16:30-16:55

16:55-17:10

17:10-17:35

17:45-18:00

The nervous sysyem displays an enormous diversity of cell types, which are assembled into neural circuits to serve for complex functions such as sensory perception and higher cognition. To build the highly ordered cytoarchitecture of the nervous system, neurons and glial cells are generated through coordinated production and placement of distinct cellular subtypes.One of the key questions in developmental biology is how the same genome in each cell can produce vastly different cell types. The identity

of each cell type is associated with its unique transcriptional profiles, which are shaped by highly ordered gene expression programs. During development, genetic information is dynamically interpreted in response in intrinsic and extrinsic factors, stochastically but highly coordinately. In this session, the speakers will talk about mechanisms of gene expression regulation that generate cellular diversity in various model organisms, including Drosophila, mice, and human stem cells.

Organizers & Chairs : Jin Woo Kim, Ph.D. (Korea Advanced Institute of Science and Technology (KAIST), Korea)), Ki-Jun Yoon, Ph.D. (Korea Advanced Institute of Science and Technology (KAIST), Korea))



Sym. 19 Molecular/Cellular Cancer Biology

Symposia

KSMCB

October 1 (Tue), 16:00-18:00, Rm. 401

Anticancer Drug Development by Targeting Cancer Metabolism: Blooming Biochemistry in the Tree of Molecular Biology in the Soil of Genetics in Cancer Biology

Soo-Youl Kim, Ph.D.Research Institute, National Cancer Center, Korea

The efficacy and mechanism of anti-PDL1-TIGIT bi-specific antibody for cancer immuno-therapy

Lei Fang, Ph.D.I-Mab Biopharma, China

Identification and characterization of new tumor suppressor functioning via degrading oncogenic RAS

Kang-Yell Choi, Ph.D.Department of Biotechnology, Yonsei University, Korea

How immunotherapy changed daily practice in clinic? : Current status and future perspective

Min Hee Hong, M.D.Department of Internal Medicine, Yonsei University College of Medicine, Korea

Young Investigator

Sym. 19-1

Sym. 19-2

Sym. 19-3

Sym. 19-4

Sym. 19-5

16:00-16:25

16:25-16:50

16:50-17:15

17:15-17:40

17:40-18:00

The innumerable causes of cancer, with the only outcome being that of unlimited growth of cells with migration to other tissues, have resulted in vastareas of cancer research, which would call for a conference bigger than the KSBMB presently being held. Because this session could cover only an extremely small aspect of tumor studies, a practical approach was adopted, and researchers focused on developing therapeutics including chemical as well as biological measures were invited. We have a very enthusiastic re (rksearcher from Shanghai developing antibodies that target cancer-related proteins. Moreover, development of drugs for

targeting cancer metabolism and cell growth, and possibly undergoing clinical trials will be presented, anticipating an exciting and promising outcome in the near future. Last but not the least, the emerging field of oncoimmunology will be further discussed by a clinician. Here, researchers working on seemingly diverse topics will be expected to develop cancer therapeutics for clinical trials, to enable the treatment of malignant diseases, the incidence of which is increasing in an aging society.

Organizer & Chair : Jaewhan Song, Ph.D. (Yonsei University, Korea)



October 1 (Tue), 16:00-18:00, Rm. 402

Sym. 20 Circadian Clock in Physicology and Behavior

Symposia

By means of circadian clock system, all the living organisms on Earth can manifest molecular processes, physiology and behavior at the advantageous times of the day and year. In moderan society, disruption of circadian clock is increasingly prevalent and has been linked as a risk for diseases such as cancer, sleep disorders, mental disorders, and metabolic disorders etc. Detailed mechanistic understanding of how circadian

clock system controls and cross-talks with physicology and behaviour would provide insights into a health and disease. In this symposium, four distinguished speakers will present their recent studies about how circadian clock system works in the brain and the role of circadian clock system in decision making, sleep/wake cycle, and aging.

Organizer & Chair : Eun Young Kim, Ph.D. (School of Medicine, Ajou University, Korea)

What wakes us: Networked circadian clocks in the brain

Erik Herzog, Ph.D.Washington University, USA

Neural mechanisms underlying circadian regulation of social priority

Han Kyoung Choe, Ph.D.Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Korea

Metabolic control of sleep-wake cycles in DrosophilaChunghun Lim, Ph.D.School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Korea

Circadian control of ORE1 by PRR9 positively regulates leaf senescence in Arabidopsis

Sunghyun Hong, Ph.D.Center for Plant Aging Research, Institute for Basic Science (IBS), Korea

Young Investigator

Sym. 20-1

Sym. 20-2

Sym. 20-3

Sym. 20-4

Sym. 20-5

16:00-16:40

16:40-17:00

17:00-17:20

17:20-17:40

17:40-17:55



Sym. 21 Bioactive Lipids in Health and Disease

Symposia

KSMCB

October 2 (Wed), 09:10-11:10, Rm. 300

Sphingolipids in Health and Disease Anthony H. Futerman, Ph.D.Department of Biomolecular Sciences, Weizmann Institute of Science, Israel

Role of Inositol pyrophosphate metabolism in the regulation of synaptic vesicle membrane fusion

Seyun Kim, Ph.D.Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Korea

The role of eosinophils supporting adipocyte maturation and glucose tolerance

YunJae Jung, M.D., Ph.D.Department of Microbiology, College of Medicine, Gachon University, Korea

Enhancement of high-density lipoproteins quantity and quality to treat dyslipidemia and hypertension by policosanol

Kyung-Hyun Cho, Ph.D.Department of Medical Engineering, Yeungnam University, Korea

27-Hydroxycholesterol is an endogenous inflammatory and immune-stimulatory molecule

Kim Koanhoi, Ph.D.Department of Pharmacology School of Medicine, Pusan National University, Korea

Young Investigator

Sym. 21-1

Sym. 21-2

Sym. 21-3

Sym. 21-4

Sym. 21-5

Sym. 21-6

09:10-09:35

09:35-09:55

09:55-10:15

10:15-10:35

10:35-10:55

10:55-11:10

Lipids are a diverse group of biological molecules with roles in membrane diversity, energy storage and signaling pathway. Recently, lipids are emerging as key molecules that regulate many physiological and pathological processes. In this symposium, leading researchers will

present roles of bioactive lipids related with signaling pathways, disease pathophysiology, regulation of adipose maturation, glucose intolerance, dyslipidemia and membrane fusion.

Organizer & Chair : Park Woo-Jae, M.D., Ph.D (Department of Biochemistry, College of Medicine, Gachon University, Korea)



October 2 (Wed), 09:10-11:10, Rm. 307

Sym. 22 Plant Genome Editing

Symposia

The new techno-wave in CRISPR-based genome editing not only open a new era in plant precision breeding, but also has amajor impact on the development of basic plant science. CRISPR-based genome editing tools are becoming increasingly diversified and sophisticated, including discovery of various Cas systems and enzymes, development of more precise Cas enzymes, increase of genome accessibility by recognizing simpler protospacer adjacent motif (PAM), invention of cytidine or adenine base editors, development of new base mutators and improvement of

homology-directed repair(HDR)-mediated genome editing technique. The evolution of genome editing technology is being immediately adapted to plant biotechnology. Earlier this year, we witnessed the commercialization of the first genome editing-based products, high oleic soybean oil (CalynoTM), based TALEN technology, the 2nd generation genome editing tool and will see much more from now on. The plant genome editing session will explore how CRISPR technology is being developed and applied in the field of plant research and crop breeding.

Organizer & Chair : Jae-Yean Kim, Ph.D. (College of Natural Science, Gyeongsang National University, Korea)

Genome editing with base editing systems from bacteria to plant

Kondo Akihiko, Ph.D.Kobe University, Japan

Genome editing for understanding plant-pollinator interactions

Sang-Gyu Kim, Ph.D.Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Korea

Genome editing using CRISPR and its applications in plants

Sangsu Bae, Ph.D.Hanyang University, Korea

Plant genome editing with CRISPR systemsHyeran Kim, Ph.D.Department of Biological Sciences, Kangwon National University, Korea

Young Investigator

Sym. 22-1

Sym. 22-2

Sym. 22-3

Sym. 22-4

Sym. 22-5

09:10-09:40

09:40-10:05

10:05-10:30

10:30-10:55

10:55-11:10



Sym. 23 Immunometabolism

Symposia

KSMCB

October 2 (Wed), 09:10-11:10, Rm. 308

Cholesterol metabolism in osteoarthritis pathogenesis

Je-Hwang Ryu, Ph.D.Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Korea

The role of TonEBP in immunometabolic disorders

Hyug Moo Kwon, Ph.D.School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Korea

Serotonin signals through a gut-liver axis to regulate hepatic steatosis

Hail Kim, M.D., Ph.D.Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Korea

Metabolic Regulation of Muscle Stem Cell Function by NAD and Protein Acetylation

Hongbo ZHANG, Ph.D.Sun Yat-sen University Zhongshan School of Medicine, China

Young Investigator

Sym. 23-1

Sym. 23-2

Sym. 23-3

Sym. 23-4

Sym. 23-5

09:10-09:35

09:35-10:00

10:00-10:25

10:25-10:55

10:55-11:10

In this session, we will discuss on recent advances in metabolism research field; particularly immunometabolism. First speaker will present that osteoarthritis is a disease associated with metabolic disorders. Also, targeting the cholesterol metabolism may provide a therapeutic avenue for treating osteoarthritis. Second speaker will talk on TonEBP which is a central component of the inflammatory enhanceosome and it is an attractive target for therapeutic agents to prevent metabolic diseases.

In their talk, we will discuss on defininf the key molecular pathways underlying the pathogenesis of NAFLD (nonalcoholic fatty liver disease). Particularly, gut-derived serotonin ameliorates hepatic steatosis through a reduction in liver serotonin receptor A2 (HTR2A) signaling. Forth talk is about the novel functions of Irisin and its receptor Intergrin alphaV on bone metabolism and thermogenesis in fat.

Organizers & Chairs : Jiyoung Park, Ph.D. (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Korea) Jang Hyun Choi, Ph.D. (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Korea)



October 2 (Wed), 09:10-11:10, Rm. 401

Sym. 24 Signal Transduction

Symposia

In addition to signal transduction mediated by diverse membrane proteins and receptors avidity and dynamic aspects including interactions and translocalizations of membrane proteins and receptors can be importantly involved in impaired regulations of cellular behaviors, leading to abnormal cellular signaling activity and functions. Thus, exploration of the dynamic aspects of membrane proteins and receptors would be critical for our efforts to identify mechanistic details for human diseases

and thereby strategies to deal with the abnormal cellular behaviors due to the dysfunctional membrane proteins. In this session, we would like to cover certain examples of membrane proteins, receptors, or targets at molecular levels that are related to development of fibrosis or cancer drug resistance or to immune synapse formation, and further to cancer-therapeutic purposes using targets on cancers.

Organizer & Chair : Jung Weon Lee, Ph.D. (College of Pharmacy, Seoul National University, Korea)

TM4SF5-mediated ROS hormesis for IPFJung Weon Lee, Ph.D.College of Pharmacy, Seoul National University, Korea

Single-molecule dynamics of cell surface receptorsYasushi Sako, Ph.D.Cellular Informatics Laboratory, RIKEN, Wako, Japan

T cell microvilli: sensors or senders?Chang-Duk Jun, Ph.D.Gwangju Institute of Science and Technology (GIST), Korea

Biology of Cancer Cell Dormancy and AwakeningHo-Young Lee, Ph.D.Seoul National University, Korea

Young Investigator

Sym. 24-1

Sym. 24-2

Sym. 24-3

Sym. 24-4

Sym. 24-5

09:10-09:35

09:35-10:05

10:05-10:30

10:30-10:55

10:55-11:10



Sym. 25 Brain Dysfunction and Infectious Disease

Symposia

KSMCBCelebrating the 30th Anniversary

October 2 (Wed), 09:10-11:10, Rm. 402

Clinical and experimental features of Sepsis-Associated Encephalopathy

Fabrice Chretien, Ph.D.Head of Experimental neuropathology laboratory, Institut Pasteur, France

Interplay between different CNS cell types during rabies virus infection

Lena Feige, Ph.D.Lyssavirus epidemiology and neuropathology laboratory, Institut Pasteur, France

Rabies-on-chip: dynamics of rabies virus infection in human neural networks

Guilherme Dias de Melo, Ph.D.Lyssavirus epidemiology and neuropathology laboratory, Institut Pasteur, France

Impact of intestinal microbiota on adult neurogenesis and behavior

Gabriel Lepousez, Ph.D.Institut Pateur Korea, Korea

Interplay of human cytomegalovirus and ISGylation

Jin-hyun Ahn, Ph.D.Sungkyunkwan University

Sym. 25-1

Sym. 25-2

Sym. 25-3

Sym. 25-4

Sym. 25-5

09:10–09:40

09:40–10:10

10:10–10:40

10:40-11:10

10:40-11:10

Brain infections are relatively rare, but they are potentially serious and have a poor prognosis although they contribute significantly to human suffering. Infections can cause inflammation of the brain and neurological or cognitive dysfunction which may have a strong negative impact on socioeconomic development. During this symposium, we will describe

a few examples of such infections causing severe diseases associated with increased morbidity and mortality that result in the loss of motor or sensory functions (sepsis, CMV), and alterations of cognition/behavior (Rabies).

Co-Organizers &Co- Chairs : Spencer Shorte (CSO, Institut Pasteur Korea), Regis Grailhe (Institut Pasteur Korea)



September 30 (Mon), 11:30-13:00, Rm. 300

GNS Global Network Session

Symposia

Organizer & Chair : Hye-Kyung Na, Ph.D. (Sungshin Women’s University, Korea)

Uncovering a second tier of transcription in the protozoan Leishmania donovani

Swati SahaUniversity of Delhi South Campus, India

Engineering live biotherapeutics for disease intervention and prevention

In Young HWANGNational University of Singapore, Singapore

The System-Wide Response to Control of Eukaryotic Translation Initiation

Paul Teesdale-SpittleVictoria University of Wellington, New Zealand

Structure and epitope studies of house dust mite allergen Der f 21 reveals a new dimension on major epitope identification

Ng Chyan LeongUniversiti Kebangsaan Malaysia, Malaysia

Overview of the Philippine General HospitalPilot Biobank and UP Diliman Cell Repository: An ASEAN Perspective

Ma. Easter Joy SajoUniversity of the Philippines Diliman, Philippines

TBA

GNS-1

GNS-2

GNS-3

GNS-4

GNS-5

GNS-6

11:30-11:45

11:45-12:00

12:00-12:15

12:30-12:45

12:45-13:00

TBA


RES Research Ethics Symposium

Luncheon Symposia

October 2 (Wed), 12:20-13:10, Rm. 307

We are living in an age when scientific achievements and new technologies rapidly change the way we live. Due to their broad impact on our society, researchers continuously encounter moral and ethical challenges of their work. The ethical concerns are likely to be more complex but crucial in every aspect of research activities and therefore it is important to make an

effort to think about the ethical issues. This symposium will focus on the authorship and researcher’s responsibility by Professor Jae In Lee (Seoul National University of Education). Professor Ock-Joo Kim (Seoul National University, College of Medicine) will also discuss how we define the ethical boundaries.

Co-Organizers & Chairs : Jung Weon Lee, Ph.D. (College of Pharmacy, Seoul National University, Korea)

The Scope and Limitations of Research Ethics Ock-Joo KIM, M.D.,Ph.D.Seoul National University, Korea

Authorship and Researcher's Responsibility Lee In Jae, Ed. D.Seoul National University of Education, Korea

12:20-12:45

12:45-13:10




October 1 (Tue), 12:20-13:10, Rm. 308

IVIM Technology’s IntraVital Microscopy (IVM) : In Vivo Live Cell Imaging Platform & Solution

Luncheon Symposia

IVIM Technology’s innovative intravital microscopy system enables dynamic 3D cellular-level imaging of various biological phenomena inside a living animal in vivo. This unique capability allows scientists to directly verify a hypothesis based on data collected in ex vivo or artificial in vitro environments in a natural and physiological in vivo microenvironment at the cellular level. Intravital microscopy has been utilized to image gene expression, protein activity, drug delivery, cell trafficking, cell-cell interaction, and physiological response to external stimuli in a live animal in vivo, which has provided unprecedented insights those were impossible to obtain with conventional static 2D observation ex vivo or in vitro. Additionally, it is possible to directly analyze the delivery and efficacy of new therapeutics such as cell therapy, gene therapy, extracellular vesicles, exosome and various biopharmaceutical products in an in vivo microenvironment. In this talk, IVIM Technology’s All-in-One IntraVital Microscopy system (IVM-C/CM/MS) will be introduced, which can acquire the

multi-color microscopic fluorescence images with sub-micron resolution in the living animal model in real time in vivo. The imaging system based on full custom-design, laser-scanning confocal/two-photon microscopy has been extensively optimized for in vivo cellular-level imaging of various internal organs in animal model for human diseases. Intravital microscopic imaging of various organs including skin, liver, spleen, pancreas, kidney, small intestine, colon, retina, lung, heart, lymph node, and bone marrow will be briefly introduced. Subsequently, recent studies utilizing the real-time intravital imaging technique to investigate dynamic cellular-level pathophysiology of various human diseases will be introduced.

• Keyword: Intravital microscopy, In vivo imaging, Fluorescence imaging, Confocal microscopy, Two-photon microscopy

Pilhan KimCEO/CTO, IVIM Technology, Korea

Associate Professor, Graduate School of Medical Science and Engineering, KAIST, Korea



Luncheon Symposia

October 2 (Wed), 12:20-13:10, Rm. 300

ABL Bio, an Innovative Biotechwith its Strong Proprietary Technologies

ABL Bio Inc., is a Korean biotech, with market capitalization of about KRW 1,500 billion with 60 employees. After being founded in February, 2016 with 14 employees, it successfully closed IPO at KOSDAQ in December, 2018. This rapid growth mainly depends on ABL Bio’s innovative proprietary technologies based on its high-profile R&D resources. Bispecific antibody (BsAb) is ABL Bio’s main platform technology that enables to connect two different antibodies together, ensuing synergistic activity of the two antibodies. BsAb technologies are being heavily applied to the pipelines for oncology and neurodegenerative diseases that have unmet medical needs as well as high business opportunities. ABL Bio’s proactive, diverse collaborations with academia, institutions, and industries worldwide has enabled ABL Bio to develop its pipelines with efficiency, high quality, and minimal risk. ABL Bio develops more than 20 pipelines. ABL001 is the most advanced BsAb asset, targeting VEGF and DLL4. Its potent anti-tumor efficacy has been proven in multiple animal studies and dose-escalating study in phase 1 trial. In clinical study, 59 % of ABL001-treated patients showed stable disease or partial response respectively up to 7.5 mg/kg of dose with no severe adverse effect or toxicity. Based on this promising result, ABL Bio plans to launch phase 1b study near future. ABL Bio has strong portfolio of immune-oncology (I/O) with its bispecific platform. In spite of potent anti-tumor activities by antibody therapeutics of immune-checkpoint inhibitors or T-cell engagers, concerns about their severe toxicity and patient population with little response have been raised. ABL 10X series are BsAbs with binding sites for tumor-associated antigen (TAA) and 4-1BB (CD137), an inducible co-stimulatory molecule found on a number of cell types, including T-cells. No T cell co-stimulation occurs in the circulation, where only the

4-1BB binding site is occupied, as 4-1BB requires clustering to deliver an activation signal. In the tumor microenvironment, however, the BsAb also binds with TAA, leading to 4-1BB clustering. Only in this case are T cells activated, resulting in the killing of tumor cells. ABL 50X series are bispecific antibodies targeting two immune modulators to increase the response rate or to improve antitumor activity by targeting two immune modulators. Its antitumor activity was confirmed in cell- and animal-models. ABL Bio expects bispecific antibodies in I/O will provide better therapeutic options for patients with low response to conventional immune-checkpoint inhibitors. ABL 301 is an α-synuclein (α-syn)-targeting BsAb for Parkinson’s disease (PD) with maximized penetrance of blood-brain barrier (BBB) and therapeutic efficacy. Its another component, a molecular shuttle (antibody for Target X), increases the BsAb’s penetrance of the BBB via a receptor-mediated transcytosis (RMT). ABL301 targets a PD-specific form of α-syn, leaving its monomeric form with functions in normal brains unharmed. Its molecular shuttle targets an undisclosed RMT receptor (Target X) that is present at levels similar to those of TfR in brain cells but, critically, much lower levels in other organs. The PD-specific mechanism and higher BBB penetration is anticipated to result in better therapeutic efficacy of ABL301 than competitor antibodies. ABL 301’s superior BBB penetration and efficacy than α-syn antibody itself has been proven in various animal models. ABL Bio plans to apply its BBB technology to other pipelines for neurodegenerative diseases, such as Alzheimer’s disease.ABL Bio is a dedicated, innovative biotech with employees fully eager to develop antibody therapeutics for patients with high unmet needs. ABL Bio will continue its effort to become a global innovator with its promise to make medicines for ‘A Better Life’.

KSMCB SecretariatThe Korea Science and Technology Center (Rm. 1105)

22, Teheran-ro 7 gil, Gangnam-gu, Seoul, 06130, Korea

international conference: korean s m cellular...

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