industry utilization, waxy corn and more - nc biotech · 2017-11-28 · industry utilization, waxy...
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Industry Utilization, Waxy Corn and More
CRISPR-CAS: Representing Abundant Potential for Agriculture
Wendy Srnic, Research Director, DuPont Pioneer
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Only DuPont can collaborate with growers acre by
acre to answer these demands. Everything we do is
about solving one problem – a complex problem that
has grown and changed with the needs of our
growing world –
C R O P P R O D U C T I V I T Y
“We put a great emphasis in managing our
grain on a much more micro level – so
looking not on a field by field basis but more
on an acre by acre and even in some cases on
a sub-acre level.”
- DuPont CustomerBIOTECH
BREEDING
CRISPR
SEED APPLIED TECHNOLOGY
CROP PROTECTION
DIGITAL SOLUTIONS
AGRONOMIC SOLUTIONS
DuPont Agriculture Key Technology Platforms
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CRISPR-Cas is DuPont Pioneer’s Preferred Gene Editing Tool
3
Zinc Finger2001–2003
Meganuclease2006–2007
TALEN2009
CRISPR-Cas2012
Time Efficiency
Quality
Cost Efficiency
Technical Flexibility
Rated on a scale of 1 – 5, with 5 being excellent.
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Next Generation Waxy Corn
Waxy Corn
• Non-functional in waxy
• Candlewax-like appearance
• Food / industrial
>97%Amylopectin
Starch
• Functional waxy gene
• Translucent appearance
• Feed / ethanol / food
No. 2 Yellow Dent Corn
75%Amylopectin
25%Amylose
Starch
Pioneer’s first commercial product through CRISPR-Cas
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Waxy Cornstarch in Everyday Consumer Products
Essential functions in food industry to improve uniformity, stability, and texture in various food products
Binding qualities for the paper-making process
Additional applications in the, corrugating, textile and adhesive industries
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The US Waxy Market
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Transgenic trait development
txn
stage C stage D stage E stage FYear 13 1st commercial planting
Year 1
Year 13
Year 11
Year 9
Year 7
Year 5
Year 3
Year 5 1st commercial planting
Next Generation Waxy corn
edit test R4-R5
event characterization &
selection
advanced testing & regulatory submissions
pre-launch
Edited variety development can be very efficient
TC1/2 R1-R5 testing
Traditional plant breeding
Year 8 1st commercial planting
DH
Backcross in Waxy
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Discovery to commercial product: The ‘invention’ is only the start…
Critical scale is required: Industry Leading Germplasm
R&D Scale:
✓ molecular tool kit
✓ genome knowledge
✓ laboratory, transformation, greenhouse
✓ field characterization (many environs.!)
✓ demo & launch
Commercial Seed Production Capability
Commercial Route to Market
End user/identity preservation system
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Appropriate, science-based regulatory oversight for plants developed with CRISPR-Cas advanced plant breeding, consistent with plants developed through other plant breeding methods
➢ Protecting health and the environment while promoting innovation
➢ Science-based, accommodate new evidence and learning
➢ Cost effective and commensurate with the risk
➢ Transparent, consistently applied and enforced
➢ Globally harmonized
✓ Gene edited plants are indistinguishable from plants that could be produced with conventional breeding tools and have a long history of safe use
✓ It is the characteristics of the plant, not the production method, that determines its safety
Considerations for Regulatory Policies
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Global Regulatory Policies for Gene Editing
➢ Global regulatory policies for geneedited products are in development
➢ Current status is related to whether or how the products of genome editing fit the scope of the existing GMO legislation in a given country
➢ The status of familiarity with genome editing and the status of deliberations on the appropriate regulatory regime vary significantly among countries
Japan
Australia
China
India
Philippines
EU
US
Argentina
Brazil
S. Korea
South
Africa
Colombia
Taiwan
New Zealand
➢ Countries with available processes or regulatory precedents:
➢ Argentina➢ Chile➢ Israel
➢ Several EU Member States
➢ U.S.➢ Canada
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Enabling CRISPR-CAS Licensing in Agriculture
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12
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CONFIDENTIAL
CIMMYT & DuPont Pioneer Public-Private Partnership
Sugarcane Mosaic Virus (SCMV)
Maize chlorotic mottle viruses (MCMV)
new to Africa, more severe then SCMV
Maize Lethal Necrosis Disease
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Products, benefits and concepts described herein will not be offered for sale or distribution until completion of field testing and applicable regulatory reviews.
DISEASE
RESISTANCE
YIELD & YIELD
STABILITY
DROUGHT
TOLERANCEOUTPUT TRAITS MATURITY
CORN • • • •
SOY • • •
CANOLA • • •
RICE • • • •
WHEAT • •
SUNFLOWER • •
Pioneer Will Deploy Advanced Breeding Broadly
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Vast Potential for Wide Array of Applications
Developing solutions to the toughest agricultural
challenges
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Let’s Work Together
openinnovation.pioneer.com
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Listening to Full Range of Stakeholders
CRISPRCas.pioneer.com