IN PROVENCE

&International Updates

Meet the Expert

SEPTEMBER 6th - 9th 2O17Palais des Papes - Convention Centre

Avignon (France)

SCIENTIFIC COORDINATORSUmberto Simeoni (Lausanne)Jean-François Tolsa (Lausanne)

FACULTY/COORDINATORSEduardo Bancalari (Miami)Virgilio Carnielli (Ancona)

Neil Marlow (London)Ola D. Saugstad (Oslo)Paolo Manzoni (Turin)

PATRONAGE

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Welcome to Provence,

The Summer Conference on Neonatology has been planned to offer neonatologists and neonatal care professionals from all countries the unique combination of scientific excellence and the particular, relaxed atmosphere offered by Provence, during a few days at the end of the summer.

This meeting is based upon an exceptionnal combination of:- the highest level of science possible in selected,- key neonatology domains,- and an unformal, summer atmosphere, in the relaxing landscapes and lifestyle of Provence.This edition will offer an outstanding faculty, as well as an increased coverage of hot topics, with the addition of perinatal infectious diseases to the program.This 3rd edition of the Summer Conference will constitute an optimal and useful break before starting the new academic year. On behalf of the Faculty,

Umberto Simeoni and Jean-François Tolsa,

CHUV & FBM, University of Lausanne, CH

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SCIENTIFIC COORDINATORSUmberto Simeoni (Lausanne, Switzerland)Jean-Francois Tolsa (Lausanne, Switzerland)

SCIENTIFIC COMMITTEEEduardo Bancalari (Miami, USA)Virgilio P. Carnielli (Ancona, Italy)

Paolo Manzoni (Turin, Italy)Neil Marlow (London, UK)

Ola D. Saugstad (Oslo, Norway)

INVITED SPEAKERSManon Benders (Utrecht, The Netherlands)

Peter Davis (Melbourne, Australia)Teresa Del Moral (Miami, USA)Antonio Del Vecchio (Bari, Italy)

Nicholas Embleton (Newcastle, UK)Drude Merete Fugelseth (Oslo, Norway)Eric Giannoni (Lausanne, Switzerland)

Moshe Hod (Petah-Tiqva, Israel)Alan Jobe (Cincinnati, USA)

Samantha J. Johnson (Leicester, UK)David Kaufman (Charlottsville, USA)

Torvid Kiserud (Bergen, Norway)Girija Ganesh Konduri (Milwaukee, USA)

Patrick McNamara (Toronto, Canada)Yvan Mivelaz (Lausanne, Switzerland)

Deirdre Murray (Cork, Ireland)Deborah O’Connors (Toronto, Canada)

Jeffrey M. Perlman (New York, USAPablo Sanchez (Columbus, USA)

Laurent Storme (Lille, France)Arjan te Pas (Leiden, The Netherlands)Bernard Thebaud (Ottawa, Canada)

Gerry Visser (Utrecht, The Netherlands)

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WEDNESDAY, 6TH SEPTEMBER 2017

17:00 WELCOME RECEPTION AND POSTER WALK

THURSDAY, 7TH SEPTEMBER 2017

08:15 Welcome address Umberto Simeoni and Jean-François Tolsa (Lausanne, Switzerland)

08:30 NEURO-COGNITIVE DEVELOPMENT Chairmen: Neil Marlow (London, United Kingdom) Umberto Simeoni (Lausanne, Switzerland)

08:30 Assessment of outcome at 2 years: can we simplify this is for the 21st century child? Deirdre Murray (Cork, Ireland)

09:00 Looking beyond IQ in preterm children Samantha J. Johnson (Leicester, United Kingdom)

09:30 Discussion

10:00 COFFE BREAK

10:20 Predicting outcomes from neonatal MRI Manon Benders (Utrecht, Netherlands)

10:50 Adult outcomes of extremely preterm birth Neil Marlow (London, United Kingdom)

11:20 Discussion

11:45 HYPERGLYCAEMIA IN PREGNANCY: A WORLDWIDE CHALLENGE TO THE MOTHER AND THE INFANT Chairmen: Umberto Simeoni and Jean-François Tolsa (Lausanne, Switzerland) Speaker: Moshe Hod (Petah-Tiqva, Israel)

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12:30 POSTER WALK

13:00 BREAK

14:00 NEONATAL INFECTIOUS DISEASE SESSION “CURRENT CHALLENGES IN THE AREA OF NEONATAL INFECTIONS” Chairmen: Paolo Manzoni (Turin, Italy); Jean-François Tolsa (Lausanne, Switzerland)

14:00 Fetal programing of immune responses: relevance to neonatal sepsis Eric Giannoni (Lausanne, Switzerland)

14:20 Challenges and open questions in neonatal immunology. Why neonates are susceptible, which is the room for immunological manipulation Antonio Del Vecchio (Bari, Italy)

14:40 Early and accurate diagnosis is challenging: what tools do we have currently? Which ones in the next future? David Kaufman (Charlottesville, United States)

15:40 Discussion

16:10 COFFE BREAK

16:30 Viral sepsis in the NICU: the new kid on the block. How to suspect, how to manage Pablo Sanchez (Columbus, United States)

17:00 Prevention and management of late-onset sepsis: an update Paolo Manzoni (Turin, Italy)

17:30 Discussion

17:50 UPDATE ON ANTENATAL STEROIDS FOR PRETERM DELIVERY Chairmen: Umberto Simeoni and Jean-François Tolsa (Lausanne, Switzerland) Speaker: Gerry Visser (Utrecht, The Netherlands)

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FRIDAY, 8TH SEPTEMBER 2017 08:00 DELIVERY ROOM HANDLING OF THE NEWBORN Chairmen: Ola Didrik Saugstad (Oslo, Norway); Umberto Simeoni (Lausanne, Switzerland)

08:00 Strategies in the delivery room and the first “Golden minutes” Jeffrey M. Perlman (New York, United States)

08:25 Ventilation strategies in the delivery room Arjan te Pas (Leiden, The Netherlands) 08:50 Oxygen in the delivery room: how much? Ola Didrik Saugstad (Oslo, Norway)

09:15 To cut or not to cut the cord, that is the question Arjan te Pas (Leiden, The Netherlands)

09:25 Discussion

09:45 COFFE BREAK

10:15 FETAL AND NEONATAL HEMODYNAMICS: A FOCUS ON ECHOCARDIOGRAPHIC ASSESSMENT Chairmen: Yvan Mivelaz (Lausanne, Switzerland) Jean-François Tolsa (Lausanne, Switzerland); 10:15 Fetal circulation Torvid Kiserud, (Bergen, Norway) 10:45 Transitional and neonatal circulations Patrick McNamara (Toronto, Canada) 11:15 The hostile perinatal environment and the heart Yvan Mivelaz (Lausanne, Switzerland)

11:45 Cardiac dysfunction Drude Merete Fugelseth (Oslo, Norway)

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12:15 Pulmonary circulation Laurent Storme (Lille, France)

12:45 Discussion

13:00 POSTER WALK

13:30 BREAK

14.30 RESPIRATORY DISORDERS AND ASSISTANCE Chairmen: Eduardo Bancalari (Miami, United States); Umberto Simeoni (Lausanne, Switzerland)

14:30 Respiratory support during transition after birth Peter Davis (Melbourne, Australia)

14:50 Antenatal associations with BPD Alan Hall Jobe (Cincinnati, United States)

15:20 Genetic and epigenetic factors in BPD Ola Didrik Saugstad (Oslo, Norway)

15:50 Discussion

16:10 COFFE BREAK

16:30 Postnatal risk factors for BPD Eduardo Bancalari (Miami, United States)

17:00 Pulmonary hypertension: a consequence of and a contributor to bronchopulmonary dysplasia in premature infants Girija Ganesh Konduri (Milwaukee, United States) 17:20 Lung regeneration: it’s all in the cord Bernard Thebaud (Ottawa, Canada) 17:50 Discussion

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SATURDAY, 9TH SEPTEMBER 2017

08:30 WOMEN ARE DESIGNED TO DELIVER VAGINALLY AND NOT BY CAESAREAN SECTION Chairmen: Umberto Simeoni and Jean-François Tolsa (Lausanne, Switzerland) Speaker: Gerry Visser (Utrecht, The Netherlands) 09:15 NUTRITION OF PRETERM INFANTS Chairmen: Virgilio Carnielli (Ancona, Italy); Umberto Simeoni (Lausanne, Switzerland)

09:15 Effect of supplemental donor human milk compared with preterm formula on neurodevelopment of very low-birth-weight infants Deborah O’Connor (Toronto, Canada)

09:45 Discussion

10:15 COFFE BREAK

10:45 Preterm gut microbiome disease outcomes and nutrient interactions Nicholas Embleton (Newcastle, United Kingdom)

11:15 Controversies on the use of probiotics in neonatology Teresa Del Moral (Miami, United states)

11:45 Extra-Uterine Growth Retardation (EUGR) of the small preterm infant: associations and outcome Virgilio Carnielli (Ancona, Italy)

12:15 Round table: too little or too much for the preterm infant Nicholas Embleton (Newcastle, United Kingdom); Virgilio Carnielli (Ancona, Italy)

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POSTER LIST

POSTER 012BRAIN IMAGING AND NEURODEVELOPMENTAL OUTCOME OF GROUP B STREPTOCOCCAL MENINGITIS IN NEONATESJ. M. S. Martis; L. A. Bok; F. J. J. Halbertsma; H. L. M. van Straaten; L. S. de Vrie; F. Groenendaal

POSTER 013DOSE EVALUATION IN NEONATAL X-RAY IMAGING USING A DIGITAL DETECTORT. J. M. Minkels; C. R. L. P. N. Jeukens; P. Andriessen; A. N. van der Linden; A. J. Dam; H. L. M. van Straaten; E. J. E. Cottaar; C. van Pul

POSTER 014EFFECTS OF OXYTOCIN ADMINISTRATION DURING PHYSIOLOGICAL-BASED CLAMPING AT PRETERM BIRTHF. Stenning; G. Polglase; M. Kluckow; A. Gill; D. LaRosa; E. Wallace; S. Hooper

POSTER 015SUBCUTANEOUS EMPHYSEMA IN THE NEONATEZ. Zimová; D. Murgaš; K. Matašová

POSTER 016LESS COMMON CAUSE OF STRIDOR IN NEWBORNST. Jurko; A. Jurko jr.; K. Matasova; P. Durdik; D. Murgas; M. Zibolen

POSTER 018A RARE CASE OF AORTOILIAC THROMBOSIS IN PREMATURE NEONATEA. Mockova; M. Matas; J. Dort; M. Cadova; M. Huml; R. Vondrakova; M. Cerny

POSTER 019IDENTIFICATION AND SUSCEPTIBILITY PATTERNS OF BACTERIAL ISOLATES FOR NE-ONATES WITH SEPSIS AT KENYATTA NATIONAL HOSPITALF. Murila; M. Milka; T. Mwanthi

POSTER 020TWO EXTREMELY LOW BIRTH WEIGHT INFANTS WITH PATENT DUCTUS ARTERIO-SUS MANAGED WITH HYPOXIA INHALATION THERAPYK. Ueda

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POSTER 021A STUDY OF RELATIONSHIP BETWEEN FOOD PROTEIN-INDUCED ENTEROCOLITIS SYNDROME AND ALLERGEN-SPECIFIC LYMPHOCYTE STIMULATION TEST IN EARLY NEONATALK. Tsuchimoto

POSTER 024BENEFITS OF SKIN-TO-SKIN CONTACT TO PRETERM NEWBORNSH. Pavlyshyn; I. Sarapuk; O. Klishch

POSTER 025KARTAGENER SYNDROME IN NEONATAL PRACTICEH. Pavlyshyn; V. Slyva; I. Sarapuk; G. Korytskyy

POSTER 026NEONATAL INTRAVASCULAR CATHETERS: AN AUDIT OF USE AND COMPLICATIONS AT GALWAY UNIVERSITY HOSPITAL (GUH)J. James; A. Binchy; E. Ryan; D. O. Donovan

POSTER 027PERINEAL GROOVE: PRESENTATION OF TWO CASESV. Mougiou; M. Kollia; E. Nana; R. Sokou; G. Kafalidis; T. Boutsikou; C. H. Salakos N. Iacovidou

POSTER 0282 CASE REPORTS OF SUBGROUP INCOMPATIBILITYV. Mougiou; M. Kollia; E. Nana; R. Sokou; G. Kafalidis; S. Valsami; T. Boutsikou; N. Iacovidou

POSTER 029HIGH BLOOD PRESSURE IN 5 TO 8 YEARS OLD CHILDREN BORN VERY PRETERM AND ADEQUATE FOR GESTATIONAL AGE: PRELIMINARY RESULTSI. D’Apremont; R. Moore; H. Poggi; M. Arancibia; D. Andrade; C. Trincado; S. Peredo; C. A. Carvajal; C. E. Fardella; C. Campino; R. Baudrand; H. Garcia; R. X. Sanchez; F. Allende; S. Solari; J. T. Ossa; S. Sifaqui; A. Martínez-Aguayo

POSTER 030NEONATAL HYPOGLYCEMIC SEIZURES: A CASE REPORTJ. Grenha; R. A. Campos; A. Ferreira; D. Soares; M. Mateus; A. L. Leite

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POSTER 033OVARIAN CYST IN A TWIN FEMALE NEONATE - A CASE REPORTM. Kollia; Ch. Salakos; M. Eleftheriades; R. Sokou; A. Kontogeorgou; T. Boutsikou; N. Iacovidou

POSTER 034CONGENITAL DIAPHRAGMATIC HERNIA AND DOUBLE-OUTLET RIGHT VENTRICLE (DORV) IN A NEONATE WITH TRISOMY 18M. Kollia; R. Sokou; G. Patsouras; P. Panagiotounakou; T. Boutsikou; N. Iacovidou; M. Theodoraki; A. Konstantinidi

POSTER 035A CASE REPORT OF EPIDIDYMO-ORCHITIS IN A MALE NEONATER. Sokou; M. Kollia; A. Lampropoulou; I. Moschari; M. Theodoraki; N. Iacovidou; A. Konstantinidi

POSTER 036FETAL GROWTH RESTRICTION: ONE CONDITION, FOUR DIFFERENT PATHOLOGIESF. Briosa; S. Moeda; S. N. Prado; H. Cavaco; F. Melo

POSTER 037EARLY NUTRITION AND NEURODEVELOPMENT: IMPLICATIONS OF PERINATAL MORBIDITIESM. Lithoxopoulou; E. Drogouti; E. Goutsiou; P. Karagianni; C. H. R. Tsakalidis; V. Soubasi

POSTER 039READMISSION PREVALENCE IN VERY LOW BIRTH WEIGHT INFANTS (VLBWI): 2-YEARS FOLLOW UPE. Pittaluga; I. D’Apremont; A. Zamorano; C. Musalem; A. Domínguez; I. Vasquez; P. Mena; J. Smith; M. Díaz; J. P. Cortés; H. Pérez

POSTER 040CURRENT DATA OF NEONATAL MORTALITY IN CATALONIA FROM 2011 TO 2016E. Capdevila; R. Porta; M. Ramon; GEN (Grup d’Estudis Neonatals de Catalunya)

POSTER 041FATAL INTRAUTERIN CAMPYLOBACTER SEPSISR. Solberg;E. Margas; H. Høyte; W. Daetz; A. P. H. Dyrbekk; N. Grude

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POSTER 042PERINATAL OUTCOME IN NEWBORNS OF MOTHERS WITH THYROID DISEASEC. Emmanouil; R. Sokou; A. Kontogeorgou; A. Kampouraki; S. Fousia; T. Boutsikou; N. Iakovidou

POSTER 043DIETARY HABITS OF EXPECTANT MOTHERS DURING PREGNANCYA. Kontogeorgou; G. Kafalidis; I. Theochari; P. Volaki; R. Sokou; T. Boutsikou; N. Iacovidou

POSTER 045MATERNAL OMEGA-3 SUPPLEMENTATION PREVENTS HYPEROXIA-INDUCED PULMONARY HYPERTENSION IN THE OFFSPRINGSY. Zhong; C. Besengez; A. Houeijeh; P. Deruelle; L. Storme

POSTER 046CERVICAL CHONDROCUTANEOUS REMNANT : A CASE REPORTG. Grivas; C. H. Emmanouil; Z. Iliodromiti; M. Kollia; E. Lampropoulou; T. Boutsikou; N. Iacovidou

POSTER 047CINICAL CASE PRESENTATION OF INFANTS WITH HAEMOPHILIA AG. Ivanov; D. Subotic; T. Mitrovic

POSTER 051NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY: A PORTUGUESE EXPERIENCES. Alves; J. Reis; D. Soares; J. Grenha

POSTER 053CHARACTERISTICS OF RESPIRATORY MORBIDITIES IN PRETERM SMALL-FOR-GESTATIONAL AGE INFANTSY. Kawase; K. Ogata; K. Hine; K. Tamaki; N. Mizukaki; H. Arai; H. Yoda

POSTER 054RUSTY PIPE SYNDROME: A CASE REPORTA. Kontogeorgou, Z. Iliodromiti, M. Kollia, C. Emmanouil, P. Volaki P, R. Sokou, T. Boutsikou, N. Iacovidou

POSTER 055FACTORS RELATED TO NEONATAL WEIGHT LOSS IN THE FIRST DAYS OF LIFE: EXPE-RIENCE FROM A GREEK BABY-FRIENDLY HOSPITALA. Kontogeorgou, Z. Iliodromiti, E. Labropoulou, I. Theochari, M. Kollia, P. Volaki,T. Boutsikou, N. Iacovidou

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The Scientific Committee would like to express their gratitude to the companies for their support

MAJOR SPONSOR

SPONSORS & EXHIBITORS

With the patronage of

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USEFUL INFO

CONGRESS VENUECentre des congrès du Palais des PapesPlace Palais des Papes84000 Avignon, France

CONGRESS MATERIALParticipants can collect badge and congress material at the Registration desk located in the Paneterie Hall.Please note that admission to Scientific Session and Social Events is restricted to partici-pants wearing their badge.

CERTIFICATE OF ATTENDANCEThe Certificate of Attendance will be available to download on the official website www.neonatalinprovence.eu at the end of the Congress.

POSTER PRESENTATIONPoster Presenters are kindly requested to hang their posters on September 6th starting from 17.30 and take them down at the end of the last day (September 9th).Poster numbers will be located on the poster panels, please check the number of your poster on the Scientific Program (POSTER LIST - page 09)

OFFICIAL LANGUAGEEnglish is the official language of the Congress.

ORGANIZING SECRETARIAT

Via Ambrogio Binda, 34 | 20143 Milan - ItalyPh. +39 02 34934404 | Fax +39 02 34934397

info@mcascientificevents.euwww.mcascientificevents.eu

Fetal and neonatal medicine from basic research to clinical practice

Original Papers

241 Prediction of Respiratory Outcome in Extremely Low Gestational Age Infants Parad, R.B.; Davis, J.M. (Boston, Mass.); Lo, J.; Thomas, M.; Marlow, N.; Calvert, S.; Peacock, J.L.; Greenough, A. (London)

249 Ketamine Attenuates the ACTH Response to Hypoxia in Late-Gestation Ovine FetusChang, E.I.; Wood, C.E. (Gainesville, Fla.)

258 Perfusion Index in Preterm Infants during the First 3 Days of Life: Reference Values and Relation with Clinical VariablesAlderliesten, T.; Lemmers, P.M.A.; Baerts, W.; Groenendaal, F.; van Bel, F. (Utrecht)

271 Cost Savings of Human Milk as a Strategy to Reduce the Incidence of Necrotizing Enterocolitis in Very Low Birth Weight InfantsJohnson, T.J.; Patel, A.L.; Bigger, H.R.; Engstrom, J.L.; Meier, P.P. (Chicago, Ill.)

277 Lung Deposition of Nebulized Surfactant in Newborn PigletsLinner, R.; Perez-de-Sa, V.; Cunha-Goncalves, D. (Lund)

283 Using Measurements of Shunt and Ventilation-to-Perfusion Ratio to Quantify the Severity of Bronchopulmonary DysplasiaDassios, T.; Curley, A.; Morley, C.; Ross-Russell, R. (Cambridge)

289 Neuro-Imaging Findings in Infants with Congenital Cytomegalovirus Infection: Relation to Trimester of InfectionOosterom, N.; Nijman, J.; Gunkel, J.; Wolfs, T.F.W.; Groenendaal, F.; Verboon-Maciolek, M.A.; de Vries, L.S. (Utrecht)

297 Infant Arterial Stiffness and Maternal Iron Status in Pregnancy: A UK Birth Cohort (Baby VIP Study)Alwan, N.A.; Cade, J.E. (Leeds); McArdle, H.J. (Aberdeen); Greenwood, D.C. (Leeds); Hayes, H.E. (Aberdeen); Ciantar, E.; Simpson, N.A.B. (Leeds)

304 CXCR4 Blockade Attenuates Hyperoxia-Induced Lung Injury in Neonatal RatsDrummond, S.; Ramachandran, S.; Torres, E.; Huang, J.; Hehre, D.; Suguihara, C.; Young, K.C. (Miami, Fla.)

Short Communication

266 Phase Changing Material: An Alternative Method for Cooling Babies with Hypoxic Ischaemic EncephalopathyThomas, N.; Chakrapani, Y.; Rebekah, G.; Kareti, K.; Devasahayam, S. (Vellore)

Fetal and Neonatal Research

Impact factor : 2.598

Editor-in-Chief

E. Gratacós, Barcelona

Fetal Diagnosis and Therapy2017: Volumes 40, 414 issues per volumeLanguage: EnglishISSN 1015–3837 (print)ISSN 1421–9964 ( online )

www.karger.com/fdt

Editors-in-Chief

H.L. Halliday, Belfast

C.P. Speer, Würzburg

Neonatology2017: Volumes 111, 1124 issues per volumeLanguage: EnglishISSN 1661–7800 (print)ISSN 1661–7819 ( online )

www.karger.com/neo

KI1

7386

Both journals are listed in bibliographic services, including: PubMed/MEDLINE, Web of Science,Google Scholar, Scopus, Embase

Karger – Medical and Scientific PublishersCH–4009 Basel, Switzerlandorders@karger.com, f: +41 61 306 12 34www.karger.comMedical and Scientific Publishers

Impact factor : 2.699

CCHD SCREENING

100%

80%

60%

40%

20%

0%

StandardScreening

StandardScreening

+

77%

93%

Improved Critical Congenital Heart Disease Screening Sensitivity vs. Clinical Assessment Alone

Zhao et al. Lancet. 2014 Aug 30;384(9945):747-54.

PERFORMANCE DURINGMOTION AND LOW PERFUSION 50%

40%

30%

20%

10%

0%

Missed True Alarms

43%Nellcor N-600

3%

50%

40%

30%

20%

10%

0%

False Alarms

28%Nellcor N-600

5%

Performance During Motion and Low Perfusion

Shah et al. J Clin Anesth. 2012;24(5):385-91.*Results shown are calculated by combining sensitivity and specificity outcomes of machine-generated and volunteer-generated motion.

RETINOPATHY OF PREMATURITY Severe Retinopathy of Prematurity Rate

Castillo et al. Acta Paediatr. 2011 Feb;100(2):188-92.

Period IPre-policy Change

Missed True Alarms False Alarms

Period IIPost-policy Change

(With Implementation of Masimo SET® in Center B)

Period IIIPost-policy Change

(With Implementation of Masimo SET® in Center A and Center B)

Nellcor N-395

0%

2%

4%

6%

8%

Nellcor N-395

10%

12%

14% Nellcor N-39513%

12%13%

5%6%

4%

Center A Center B Center A Center B Center A Center B

For more information, visit www.masimo.co.uk

For professional use. See instructions for use for full prescribing information,including indications, contraindications, warnings, and precautions.© 2017 Masimo. All rights reserved.

Masimo SET®: Advancing Patient SafetyClinical Studies: The Performance of Masimo SET®

Measure-through Motion and Low PerfusionTM Pulse Oximetry

Masimo SET®, coupled with changes in clinical practice, led to a significant reduction in rates of severe Retinopathy of Prematurity (ROP)

When combined with clinical assessment, Masimo SET® improved critical congenital heart disease (CCHD) screening sensitivity to 93%

Masimo SET® had 3% missed true alarms and 5% false alarms versus 43% and 28%, respectively, using competitor technology

PLCO

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PLLT

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