immunity to viruses - rdmc.nottingham.ac.uk of immunology...the infective life cycle of viruses...
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The infective life cycle of viruses
Infecting virus
Attachment to cell receptors
(tropism)
Penetration
Uncoating
Replication Synthesis of viral mRNA
Synthesis of viral proteins Synthesis of viral nucleic acids
Assembly Capsid formed
around nucleic acid
Release Lytic virus (no envelope) Budding virus (envelope)
Anti-viral effects of antibodies
• Antibody alone - blocks binding and entry to cells
• Antibody + complement - damage to enveloped viruses - opsonisation for phagocytosis
• Antibody bound to infected cells - antibody-dependent cellular cytotoxicity
Antigenic drift and shift in influenza virus
Strains of influenza A virus can be defined by the antigenic type of their capsid proteins – haemagglutinin (H) and neuraminidase (N).
H0N1
H3N2 H2N2
H1N1
(1933 – 1946)
(1968 – ) (1957 – 1967)
(1947 – 1956)
Innate and adaptive immunity to virus infected cells
Virus titre
Time after virus infection
Innate Adaptive
The anti-viral action of interferons
Type 1 interferons also enhance the expression of HLA class I proteins, and activate natural killer cells.
Formation of enveloped RNA virus
Virus glycoproteins
Host cell plasma membrane
Virus matrix proteins
Virus RNA
Virus formation
Virus budding
Virus release
(HLA class I expression is inhibited by a number of viruses, eg. adenovirus, cytomegalovirus, herpes simplex virus.)
Video can be viewed on YouTube
Title: T cell Attack
URL: http://www.youtube.com/watch?v=nL_VyrTR2r4
Target cell killing by a cytotoxic T cell