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Immune Panel

Health Action Plan

October 1, 2019

Demo ClientKit #1234ABCD5678

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Table of Contents

Understand Your Genetics

How These Traits Affect You

Recommendations

Supplements

Diet

Lifestyle

Exercise

Further Testing

Traits

Inflammation

Rheumatoid Arthritis

Recommendation Detailed Appendix

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Understand Your GeneticsThis report is broken down into three main sections: TraitImpact, Recommendations and Trait Detail. Depending onthe number of traits being reviewed, your report willcontain multiple trait and recommendation detailsections. Terms and sections of the report are definedbelow.

DNA

DNA is a long, ladder-shaped molecule. The rungs of the ladder are madeof two amino acids pairing together, these are called bases. They alwayspair the same way, A (Adenine) with T (Thymine), and C (Cytosine) with G(Guanine). The body is constantly replicating DNA strands.

GENE

Genes are the basic units of heredity (passeddown from generation to generation). Theyare made of DNA and provide theinstructions for how our body works, whatwe look like, etc. Humans have between20,000 - 25,000 genes. We inherit half ofthem from our mother and half from ourfather.

SNP

A SNP is a Single Nucleotide Polymorphism. SNPsoccur when the amino acids making up the basepair do not come together in the same way as theoriginal DNA strand. For example, the originalstrand may have had an A but the replicatedstrand has a G. SNPs are common and many ofthem have no impact to the individual, however,some can change how our body works.

VARIANT

Variants are how SNPs are referred to in thisreport. When the amino acid in the copiedstrand is different from the original, it iscalled a variant - it varies from the original.Variants are not necessarily 'good' or 'bad'they are simply different from the original.The depiction of variants is shown as: +/+(both copies have different amino acids), +/-(one copy has a different amino acid), -/-(both copies have the same amino acid as theoriginal) or U (one copy is indeterminate).

Reading This Report

Trait Impact Traits Recommendations

This report focuses on traits. These aretypically groups of SNPs that have asimilar impact on the body’s function.We use a proprietary algorithm todetermine the impact a group of SNPsmay have on a specific function in thebody based on your individual testresults.

The traits in our reports aretypically grouped by body function,a symptom type, a disease, anutrient need, or a response toenvironment. Within the traitpages, you will see the SNPs thatare looked at for that trait, yourvariant type and recommendationsto optimize health and minimize riskbased on your individual results.

Your genes, and therefore yourSNPs, will not change during yourlife. However, this report focuseson SNPs whose impact can beinfluenced by external factors likediet, exercise, supplements, andlifestyle changes.

Disclaimer - The recommendations in this report have been carefully prepared and reviewed for you by your health and wellness provider, based on his or herreasoned medical judgment about your personal health needs. Be sure that you have shared with your health and wellness provider all relevant information aboutyour health, including any medications or dietary supplements you may be taking, and any medical conditions you may be experiencing, before you adopt any of theserecommendations. This test is performed via DNA sequencing. As with all genetic testing with the highest possible standards, the data generated during thelaboratory process will have a <99% sensitivity and specificity.


How These Traits Affect You This page provides a high-level snapshot of the clinical significance of each trait within this panel. The results are intwo categories: traits that are ranked high, medium or low impact as well as traits for which there is an explicit result(i.e. categorical such as "yes" or "no"). At the end of this page are a summary of any non-reportable (NR) traits. Theresults for these traits are unable to be determined from the sample submitted. Recommendations are made for traitswith high or medium impact only.

Impact Traits Impact Learn More

1 Inflammation HIGH Page 11

2 Rheumatoid Arthritis MEDIUM Page 13

3 Hashimoto's Thyroiditis LOW

4 Multiple Sclerosis LOW

5 Psoriasis LOW

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High

Medium

Low

Impact Traits

Immune Panel


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SupplementsBelow is a list of the top recommended supplements curated specifically for you. These recommendations mayrepresent a subset of the total recommendations found within the Supplement sections of your report.Recommendations are listed in order of importance based on your individual genetic results. Theserecommendations have been reviewed by your healthcare provider. Please contact your provider if you have anyquestions.

Recommendation Name The Details Linked Traits

Curcumin Supplement with 250 - 2,000 mg of curcuminextract per day.

Inflammation, Rheumatoid Arthritis

Vitamin D3 Supplement with 3,000 IUs of vitamin D3 perday.


Ashwagandha Supplement with 250 - 300 mg ofashwagandha per day.


Betaine Hydrochloride(HCl)

Supplement with 1 - 2 g of betainehydrochloride (HCl) with meals for at least 6months.

Inflammation

Borage Oil Supplement with 2.7 g per day of borage oilper day.


Cannabinoid Supplements Consider using cannabinoid supplements formanaging pain.


Folate Supplement with 400 - 800 mcg of methyl-folate per day.

Inflammation

Multivitamin Supplement with a multivitamin that includesactivated B vitamins.

Inflammation

Omega-3 Supplement with 2 - 5 g of omega-3 fattyacid supplement that contains essential fattyacids DHA and EPA.


Pomegranate Extract Supplement with 500 mg of pomegranateextract per day.


Note - If you are taking any medications, consult with your practitioner before starting any new supplements as they may have adverseeffects with your medications.

Immune Panel Recommendations


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DietBelow is a list of the top dietary recommendations curated specifically for you. These recommendations mayrepresent a subset of the total recommendations found within the Diet sections of your report. Recommendationsare listed in order of importance based on your individual genetic results. These recommendations have beenreviewed by your healthcare provider. Please contact your provider if you have any questions.


Mediterranean Diet Adopt a Mediterranean-style diet thatincludes a variety of antioxidant-rich foods,heart healthy fats, and complexcarbohydrates.


Allergen Free Diet Eliminate common allergenic foods from thediet, including wheat, corn, dairy, shellfish,nuts, eggs, and soy.


Anti-Inflammatory Diet Consume a diet rich in anti-inflammatoryfoods.

Inflammation

Dietary Fiber Increase dietary fiber intake to recommended25 g for females and 30 g for males.

Inflammation

Fruits and Vegetables Include fruits and vegetables at every meal toincrease levels of antioxidants in the body,especially strawberries, blueberries, broccoli,sprouts, and green leafy vegetables.

Inflammation

Juice Fasting Try a fruit and vegetable juice fast for 5 to 7days.


Nut Consumption Consume a variety of nuts including almonds,walnuts, macadamia nuts, and brazil nuts.

Inflammation

Omega-3 Rich Foods Consume a diet rich in omega-3 fatty acids. Inflammation



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LifestyleBelow is a list of the top lifestyle recommendations curated specifically for you. These recommendations mayrepresent a subset of the total recommendations found within the Lifestyle sections of your report.Recommendations are listed in order of importance based on your individual genetic results. Theserecommendations have been reviewed by your healthcare provider. Please contact your provider if you have anyquestions.


Cognitive BehavioralTherapy

Use cognitive behavorial therapy toreprogram responses to pain.


Intermittent Fasting Try intermittent fasting (fasting for 14+ hoursdaily) or alternate day fasting (fasting for 24hours every other day).

Inflammation

Meditation Engage in 10 to 20 minutes of mindfulnessmeditation 2 or more times per week.


Sleep Consistency Stick to a consistent sleep routinue thatconsists of going to sleep and waking up atapproximately the same time each day.

Inflammation

Use Natural Personal CareProducts

Use natural care products that do not containenvironmental toxins such as formaldehyde,phthalates, parabens, lead, mercury, triclosan,and benzophenone.




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ExerciseBelow is a list of the top exercise recommendations curated specifically for you. These recommendations mayrepresent a subset of the total recommendations found within the Exercise sections of your report.Recommendations are listed in order of importance based on your individual genetic results. Theserecommendations have been reviewed by your healthcare provider. Please contact your provider if you have anyquestions.


Cross Training Aim to perform cross training that includescardio, weight training, and sportsmovements performed twice per week.




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Further TestingBelow is a list of the top further testing recommendations curated specifically for you. These recommendations mayrepresent a subset of the total recommendations found within the Further Testing sections of your report.Recommendations are listed in order of importance based on your individual genetic results. Theserecommendations have been reviewed by your healthcare provider. Please contact your provider if you have anyquestions.


C-Reactive Protein (CRP) orhsCRP

Test levels of C-Reactive Protein (CRP) orhsCRP


Erythrocyte SedimentationRate (ESR)

Test erythrocyte sedimentation rate (ESR) inblood


Anti-MycoplasmaFermentans Antibodies

Test for Anti-mycoplasma fermentansantibodies


Epstein-Barr Virus (EBV) Test for the Epstein-Barr Virus (EBV) Rheumatoid Arthritis

Fibrinogen Test fibrinogen levels in the body Inflammation

Folate Testing Test folate levels Inflammation

Food Sensitivity Testing Test for food sensitivities Rheumatoid Arthritis

Homocysteine Levels Check blood homocysteine levels Inflammation

IL-6 Testing Test for levels of IL-6 Inflammation

TNF-alpha Test for TNF-alpha Inflammation



Trait Details

Appendix 1

Immune Panel

October 1, 2019


Inflammation People with similar genetic markers may be more likely to experience increased levels of inflammation, which is thebody’s natural response to an injury, wound, or infection.

Gene SNP Variant Impact

TNF-α rs1800629 +/+ High

IL6 rs1800795 +/+ High

TNF-α rs1799724 +/- Medium

PTPN22 rs2476601 +/- Medium

IL-10 rs1800872 +/- Low

TNF-α rs1799964 -/- Low

IL23R rs2201841 +/- Low

IL-10 rs3024505 -/- Low

Recommendations

These recommendations are based on the genetic findings in the chart above.

SUPPLEMENT • Multivitamin • Betaine Hydrochloride (HCl)

• Vitamin D3 • Folate

• Curcumin

DIET • Anti-Inflammatory Diet • Omega-3 Rich Foods

• Dietary Fiber • Mediterranean Diet

• Nut Consumption • Fruits and Vegetables

LIFESTYLE • Sleep Consistency • Intermittent Fasting

FURTHER TESTING • Homocysteine Levels • IL-6 Testing

• C-Reactive Protein (CRP) orhsCRP

• Erythrocyte SedimentationRate (ESR)

• Fibrinogen • Folate Testing

Immune Panel High Impact


• TNF-alpha

Immune Panel High Impact


Rheumatoid Arthritis People with similar genetic markers may be at a higher risk for developing rheumatoid arthritis.

Gene SNP Variant Impact

TNFAIP3 rs6920220 +/+ High

ANAPC4 rs3816587 +/+ High

PTPN22 rs1217410 +/+ High

PTPN22 rs2476601 +/- Medium

REL rs13031237 +/- Medium

STAT4 rs7574865 +/- Medium

CCR6 rs3093024 +/- Medium

NCF4 rs729749 +/- Medium

AFF3 rs10865035 +/- Medium

TNFAIP3 rs5029937 -/- Low

C6orf10 rs6910071 -/- Low

NOS3 rs2070744 -/- Low

CDK6 rs42041 -/- Low

TNFAIP3 rs2230926 -/- Low

TLR3 rs3775291 -/- Low

CD40 rs4810485 -/- Low

HLA-DRB1 rs615672 +/- Low

Recommendations

These recommendations are based on the genetic findings in the chart above.

SUPPLEMENT • Omega-3 • Vitamin D3

• Curcumin • Wormwood

• Borage Oil • Pomegranate Extract

• Ashwagandha • Cannabinoid Supplements

DIET • Mediterranean Diet • Juice Fasting

• Allergen Free Diet

Immune Panel Medium Impact


LIFESTYLE • Use Natural Personal CareProducts • Meditation

• Cognitive Behavioral Therapy

EXERCISE • Cross Training

FURTHER TESTING • Anti-MycoplasmaFermentans Antibodies • Epstein-Barr Virus (EBV)

• Testing for Mold/Mildew • C-Reactive Protein (CRP) orhsCRP

• Erythrocyte SedimentationRate (ESR)

• Testing for Early Markers ofInflammation andAutoimmunity

• Food Sensitivity Testing

Immune Panel Medium Impact


Recommenda�on

Detailed Appendix

Appendix 2

Immune Panel

October 1, 2019


Supplements


Curcumin Supplement with 250 - 2,000 mg of curcumin extract per day. Inflammation, RheumatoidArthritis

Vitamin D3 Supplement with 3,000 IUs of vitamin D3 per day. Inflammation, RheumatoidArthritis

Ashwagandha Supplement with 250 - 300 mg of ashwagandha per day. Rheumatoid Arthritis

Betaine Hydrochloride(HCl)

Supplement with 1 - 2 g of betaine hydrochloride (HCl) with meals for atleast 6 months. Inflammation

Borage Oil Supplement with 2.7 g per day of borage oil per day. Rheumatoid Arthritis

CannabinoidSupplements Consider using cannabinoid supplements for managing pain. Rheumatoid Arthritis

Folate Supplement with 400 - 800 mcg of methyl-folate per day. Inflammation

Multivitamin Supplement with a multivitamin that includes activated B vitamins. Inflammation

Omega-3 Supplement with 2 - 5 g of omega-3 fatty acid supplement that containsessential fatty acids DHA and EPA. Rheumatoid Arthritis

Pomegranate Extract Supplement with 500 mg of pomegranate extract per day. Rheumatoid Arthritis

Wormwood Supplement with 30 g of wormwood per day. Rheumatoid Arthritis

Diet

RecommendationName

The Details Linked Traits

MediterraneanDiet

Adopt a Mediterranean-style diet that includes a variety of antioxidant-rich foods,heart healthy fats, and complex carbohydrates.

Inflammation,Rheumatoid Arthritis

Allergen Free Diet Eliminate common allergenic foods from the diet, including wheat, corn, dairy,shellfish, nuts, eggs, and soy. Rheumatoid Arthritis

Anti-InflammatoryDiet Consume a diet rich in anti-inflammatory foods. Inflammation

Dietary Fiber Increase dietary fiber intake to recommended 25 g for females and 30 g for males. Inflammation

Fruits andVegetables

Include fruits and vegetables at every meal to increase levels of antioxidants in thebody, especially strawberries, blueberries, broccoli, sprouts, and green leafyvegetables.

Inflammation

Juice Fasting Try a fruit and vegetable juice fast for 5 to 7 days. Rheumatoid Arthritis


Nut Consumption Consume a variety of nuts including almonds, walnuts, macadamia nuts, and brazilnuts. Inflammation

Omega-3 RichFoods Consume a diet rich in omega-3 fatty acids. Inflammation

Lifestyle


Cognitive BehavioralTherapy Use cognitive behavorial therapy to reprogram responses to pain. Rheumatoid

Arthritis

Intermittent Fasting Try intermittent fasting (fasting for 14+ hours daily) or alternate day fasting (fastingfor 24 hours every other day). Inflammation

Meditation Engage in 10 to 20 minutes of mindfulness meditation 2 or more times per week. RheumatoidArthritis

Sleep Consistency Stick to a consistent sleep routinue that consists of going to sleep and waking up atapproximately the same time each day. Inflammation

Use Natural PersonalCare Products

Use natural care products that do not contain environmental toxins such asformaldehyde, phthalates, parabens, lead, mercury, triclosan, and benzophenone.

RheumatoidArthritis

Exercise

RecommendationName

The Details Linked Traits

Cross Training Aim to perform cross training that includes cardio, weight training, and sportsmovements performed twice per week.

RheumatoidArthritis

Further Testing


C-Reactive Protein (CRP) or hsCRP Test levels of C-Reactive Protein (CRP) or hsCRP Inflammation, RheumatoidArthritis

Erythrocyte Sedimentation Rate (ESR) Test erythrocyte sedimentation rate (ESR) inblood

Inflammation, RheumatoidArthritis

Anti-Mycoplasma Fermentans Antibodies Test for Anti-mycoplasma fermentans antibodies Rheumatoid Arthritis

Epstein-Barr Virus (EBV) Test for the Epstein-Barr Virus (EBV) Rheumatoid Arthritis

Fibrinogen Test fibrinogen levels in the body Inflammation


Folate Testing Test folate levels Inflammation

Food Sensitivity Testing Test for food sensitivities Rheumatoid Arthritis

Homocysteine Levels Check blood homocysteine levels Inflammation

IL-6 Testing Test for levels of IL-6 Inflammation

TNF-alpha Test for TNF-alpha Inflammation

Testing for Early Markers of Inflammation andAutoimmunity

Testing for early markers of inflammation andautoimmunity Rheumatoid Arthritis

Testing for Mold/Mildew Test for mold/mildew exposure Rheumatoid Arthritis


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