hypoglycaemic and hypoglycaemic effect of morinda citrifolia.ppt
TRANSCRIPT
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HYPOGLYCAEMIC ANDHYPOCHOLESTEROLAEMIC
EFFECT OF MORINDACITRIFOLIA(NONI) SYRUP
ON FEMALE NIDDMSUBJECTSBY
DR CHANDRA VENKATASUBRAMANIAN &
K.PRIYAREADER AND ADDITIONAL HEAD , DEPARTMENT OF HOME
SCIENCE , QUEEN MARYS COLLEGE, CHENNAI - 4
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Introduction
Diabetes mellitus is emerging as oneof the main threats to human health.The prevalence of this condition and
its mortality rate has increased fromfive percent to 20 percent. India isreported to be the world capital for
Diabetes mellitus.
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Certain foods have functional properties
which are beneficial in controlling theblood sugar levels. In India herbalplants used for Diabetes mellitus have
shown to possess anti diabetic propertyMorinda Citrifolia (NONI) known as theIndian Mulberry has been used for food
and medicinal purposes for more than2000 years.
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The Indian mulberry fruit(NONI) contains
phytochemicals, organicacids, terpenes, sterols,glycosides, amino acids,anthroquinones, phenoliccompounds and alkaloids
High amount of calcium,potassium, phosphorusand magnesium
Due to its high nutritient
content the fruit is used asa health drink throughoutthe world.
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Noni syrup is consideredimportant due to its unique
Therapeutic
Antiviral and Antitumour
Anti helmintic,Analgesic andHypotensive potential
Anti inflammatory and
immune enhancing Hypocholesterolaemic
and Hypoglycaemic
effect
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Thus the present study was carriedout to find out its Hypoglycaemic and
Hypocholesterolaemic effect on
selected middle aged female NonInsulin Dependent Diabetes Mellitus
(NIDDM) subjects.
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Methodology
Hundred middle aged female NIDDM subjectswere randomly selected and their nutritionalstatus was assessed by anthropometry,biochemical examination and diet survey
Biochemical parameters such as FBS,PPBS,HBA1C and Lipid profile were recorded.
Only co operative subjects were selected for thestudy
Eight subjects each formed the experimentalgroup (those who were administered the NONIsyrup)and control group (those who were notadministered the NONI syrup)
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The Criteria used for the selection ofthe study subjects were -
Women in the age group of 35 to 55 years
Fasting blood glucose >130 mg/dl
Serum total cholesterol > 230 mg/dl
Should be co operative for entire study period
Should donate blood at the beginning and endof the study period (60 days).
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This study was planned for 90 daysand conducted for a period of 60
days only from december 2007 tofebruary 2008
The experimental group was given 30
ml of NONI syrup in two equal doses of15 ml each in the morning beforebreakfast and at bedtime beforedinner.
This is the standard dose prescribedby Dr P.I. Peter in his Monographs onNONI, 2008.
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Periodic visits by the researcher wastaken up to ensure that the subjectsunder study adhered to the dietary
regimen and were taking NONI syrup
regularly.The anthropometric measurementssuch as height and weight were
measured and the blood sample wasdrawn from the selected subjects on0 day and day 60 of the study period.
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Results and Discussion
Anthropometric measurements of experimental
group
Anthropometricmeasurements
ExperimentalGroup
0 Day
Mean
S.D
ExperimentalGroup
60th Day
Mean
S. D
t Value
Weight 67.25 13.49 64.75 13.69 1.832 **
Body Mass Index 27.21 5.75 26.20 5.85 11.769****Significant atone percentlevel
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Results and Discussion
Anthropometric measurements of Control group
Anthropometricmeasurements
Control Group
0 Day
Mean S.D
Control Group
60th Day
Mean S. D
t Value
Weight 74.13 10.64 74.80 11.48 1.132 NS
Body Mass Index 30.69 5.01 30.97 5.00 1.288 NS
NSnot significant
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Statistical analysis revealed that
when comparing the weight andBody Mass Index of experimentaland control groups, there was a
highly significant lowering ofweight and Body Mass Index of theexperimental group as compared to
the control at one percent level.
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Blood parameters (glucose andHBA1C) of the experimental group
Blood parameters Experimentalgroup
0 Day
Experimentalgroup
60th Day
t Value
Fasting bloodglucose(mg/dl)
165.71 21.66 120.25 19.83 8.348**
Post prandialblood
glucose(mg/dl)
269.25 28.01 171.13 21.81 22.294**
HBA1C 8.14 0.86 7.18 0.65 7.773**
**Significant atone percentlevel
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Blood parameters (glucose andHBA1C) of the Control group
Bloodparameters
Experimentalgroup
0 Day
Experimentalgroup
60th Day
t Value
Fasting bloodglucose(mg/dl)
74.13 10.64 74.8 11.48 1.251 NS
Post prandialblood
glucose(mg/dl)
30.69 5.01 30.97 5.27 0.068 NS
HBA1C 8.44 0.79 8.44 0.71 0.729 NS
NS not significant
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Statistical analysis revealed thatwhen comparing the mean fastingblood glucose, post prandial bloodglucose and HBA1C values of the
experimental and the controlgroup, there was a highlysignificant lowering of the above
in the experimental group ascompared to the control at one
percent level.
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Serum lipid profile ofexperimental group
Blood parameters Experimentalgroup
0 Day
Experimentalgroup
60 Day
t Value
Serum totalcholesterol
(mg/dl)
248.25 17.98 195.50 15.84 9.254**
Serum triglyceride(mg/dl)
285.75 48.85 190.73 23.27 6.678**
HDL cholesterol(mg/dl)
47.13 9.49 47.88 9.28 0.513 NS
LDL cholesterol(mg/dl)
140.50 20.51 109.50 18.72 3.870**
VLDL cholesterol(mg/dl)
56.88 9.98 38.13 4.55 6.180**
**Significant
at one percentlevel
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Serum lipid profile of Control groupBlood parameters Control group
0 Day
Control group
60 Day
t Value
Serum totalcholesterol (mg/dl)
251.50 18.00 255.98 21.21 0.361 NS
Serum triglyceride(mg/dl)
298.25 53.58 300.33 44.27 0.488 NS
HDL cholesterol(mg/dl)
33.42 9.66 33.81 7.26 2.861 NS
LDL cholesterol(mg/dl)
158.38 20.26 166.63 57.58 1.754 NS
VLDL cholesterol(mg/dl)
59.75 10.67 60.00 8.72 0.557 NS
Not significant
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Statistical analysis revealed that
in the experimental group therewas a highly significant
reduction in the serum total
cholesterol, serum triglyceride,LDL and VLDL cholesterol at one
percent level as compared to thecontrol group
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ConclusionThus it can be concluded that Morinda
Citrifolia/NONI/Indian Mulberry syrup is avery good Hypo glycaemic andhypocholesterolaemic agent.
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Thus it can be confidently stated thatwhen the effect of NONI is so
statistically sound for short termstudies then how mind blowing the
results should be for long term
studies of six months or so
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Thank you