hyperthermia applicator for small superficial tumour treatment paolo togni 1,jan vrba 1, luca...
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Hyperthermia Applicator for Small SuperficialHyperthermia Applicator for Small SuperficialTumour TreatmentTumour Treatment
Paolo TOGNIPaolo TOGNI1 1 ,Jan VRBA,Jan VRBA 1 1 , Luca VANNUCCI , Luca VANNUCCI22
11Dept. of EM Field, Czech Technical University in PragueDept. of EM Field, Czech Technical University in Prague22Dept.of Immunology, Institute of Microbiology, Academy of Sciences of Dept.of Immunology, Institute of Microbiology, Academy of Sciences of
Czech RepublicCzech Republic
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OutlineOutline
Introduction Introduction on on experimental research experimental research
Applicator design descriptionApplicator design description
Computer Simulation optimizationComputer Simulation optimization
Experimental evaluationExperimental evaluation
In-vivo experimentsIn-vivo experiments
ConclusionsConclusions
ResearchResearch
Microwave Hyperthermia as anti-cancer Microwave Hyperthermia as anti-cancer treatment treatment
Study morphological changes induced in Study morphological changes induced in superficial layerssuperficial layers
Immunological responses Immunological responses
Melanoma in animal model Melanoma in animal model
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Model Model CharacteristicsCharacteristics
Small tumour Small tumour dimensions:dimensions:
diameter 15-20 mmdiameter 15-20 mm
Limited deepness:Limited deepness:
around 10 mmaround 10 mm
Small animal body Small animal body
SubcutaneousSubcutaneous
Applicator Applicator RequirementRequirement
Focused HeatingFocused Heating
Limited E-field Limited E-field penetration depthpenetration depth
Superficial CoolingSuperficial Cooling
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Applicator Design (I)Applicator Design (I)
Planar StructurePlanar Structure
Squared resonant cavitySquared resonant cavity
Circular Slot-line radiating apertureCircular Slot-line radiating aperture
Working Frequency Working Frequency
2450 MHz (ISM)2450 MHz (ISM)
Agar Phantom
Water BolusPlanar Applicator
Applicator Design (II)Applicator Design (II)
Coaxial cable feedingCoaxial cable feeding
Just TM mode can be excitedJust TM mode can be excited
Dominat Mode Dominat Mode TTMM111010
SS11 11 ParameterParameter Evaluation Evaluation
Opimized using Computer simulator:Opimized using Computer simulator:
Cavity dimensionsCavity dimensions Slot line aperture WidthSlot line aperture Width
Vector analzyer measurements:Vector analzyer measurements:
Low Bolus thikness dLow Bolus thikness deependentpendent High cHigh contact ontact dependentdependent Integrated bolus Integrated bolus neededneeded
SAR distributionSAR distribution inside phantominside phantom
Low Penetration DepthLow Penetration Depth
SAR distributionSAR distribution on phantom surfaceon phantom surface
Tumour covering depends on bolus Tumour covering depends on bolus thicknessthickness20 mm optimal thickness for our 20 mm optimal thickness for our mouse modelmouse model
Temperature distribution measurementsTemperature distribution measurements
IR Camera measurement:IR Camera measurement:
Limited Temperature Limited Temperature penetrationpenetration
Better results expected on Better results expected on animal model for the effect of animal model for the effect of blood perfusionblood perfusion
Without Water BolusWithout Water Bolus
Temperature distribution measurementsTemperature distribution measurements
IR Camera measurement:IR Camera measurement:
Effective Superficial coolingEffective Superficial cooling
Reduced Reduced temperature temperature penetration depthpenetration depth
70 mm
6 mm
With Water BolusWith Water Bolus
System for HyperthermiaSystem for Hyperthermia
In-vivo ExperimentsIn-vivo Experiments
Proper tumour temperature during treatmentProper tumour temperature during treatment Suitable skin coolingSuitable skin cooling Limited body temperature enhancement during treatmentLimited body temperature enhancement during treatment
ConclusionConclusion
Applicator suitable to treat small superficial Applicator suitable to treat small superficial tumourstumoursSuitable tumour coveringSuitable tumour coveringReduced enhancement of body Reduced enhancement of body temperature expectedtemperature expectedSuitable to used on surfaces with complex Suitable to used on surfaces with complex contourcontourPerspective of clinical practice also in Perspective of clinical practice also in array configurationarray configuration
Acknowledgements:
This study is funded by the Grant Agency of the Academy of Sciences of the Czech Republic IAA500200510, Institutional Research Concepts No. AV0Z50200510 and by the Grant Agency of the Czech Republic, Grant No.102/08/H081
Thank you for your attention!Thank you for your attention!