humarian patient ebook 2-17-15

1

HUMARIANRESEARCH LAB, LLC

PROBONIX: The Key to Natural Health

www.humarianresearchlab.com


1

The Key to Optimal Health is yourGastrointestinal (GI) System!

Reduce Bloating and Flatulence, Improve Digestion, Promote Bowel Regularity, Quench Toxins, Reduce GI Inflammation, Support Immune Health, Reduce Dairy Intolerance, Reduce Allergic Responses, and Repair Damaged Intestinal Lining all with One Simple Solution.

When the digestive system is unhealthy and out of balance, the following signs and symptoms may occur:

• Bloating,belching,burning,andflatulenceaftermeals

• Weightgain

• Depression

• Anxiety

• IncreasedriskofAutism

• ADD/ADHD

• MentalFogginess

• Insomnia

• Asenseoffullnessaftereating

• Indigestion,diarrhea,constipation

• Systemicreactionsaftereating,suchassweating

• Nauseaordiarrheaaftertakingsupplements

• Rectalitching

• Weakorcrackedfingernails

• Dilatedbloodvesselsinthecheeksandnoseinthenon-alcoholic

• Post-adolescentacneorotherskinirritationssuchasrosacea

• Irondeficiency

• Chronicintestinalinfections,parasites,yeast,unfriendlybacteria

• Undigestedfoodinthestool

• Greasystools

• Skinthatbruiseseasily

• Fatigue

• Amenorrhea(absenceofmenstruation)

• Chronicvaginitis(vaginalirritation)

• Autoimmunediseases



2

How can an unhealthy digestive system cause so many issues?

Manypeoplethinkofthegutsolelyasthemechanismbywhichthebodydigestsfood.However,yourgastrointestinal(GI)tractismuchmorethanadigestioncenter;infact,inthescientificcommunityitisliterallycalledyoursecondbrain.1Thegutiscalledyoursecondbrainbecauseitcontrolsthecomplexprocessofdigestionwithoutassistanceofthebrain,becauseithasitsownnervoussystemknownasthe“entericnervoussystem.”

Didyouknowthegut(secondbrain)produces95%ofthe“happy/feelgood”chemical,calledserotonin?Withoutadequatelevelsofserotonin,weexperienceinsomniaanddepression,becausethechemicalsproducedinthegutaffectthewholebody.Thisisknownasthe“gut/brainaxis.”Thismeansthatthesamechemicalsthatinfluenceyourgastrointestinalsystemaffectalsoyourendocrine(hormone),immune,behavioral,andemotionalfunctions.2 As youcansee,regardingtheGIasadigestioncenteronlyisanunfortunateoversimplification,becausedysfunctionsoftheGIisoneoftheprimarycontributingfactorstomanychronichealthproblems,suchas:troublelosingweight,

sinus/allergyproblems,andautoimmunedisordersworldwide,justtonameafew.

A healthy gut has four primary functions3:

1. Digestionoffoodandabsorption/distributionofnutrients

2. Preventionoftoxinsand“bad”bacteriafromenteringthebody

3. Siteforspecializedcellsthatproducedigestiveenzymes,peptidehormonesand “neurotransmitters,”suchasserotonin.

4. Actsasacommunicationcentertotheendocrineandimmunesystemsaboutthe outside environment.

Thegastrointestinalsystemissoimportanttoyouroverallhealththatthefatherofmodernmedicine,Hippocrates,wholived400yearsbeforeJesusChrist(over2,400yearsago)oncesaid,“Alldiseasebeginsinthegut!”Itissaid,“Knowledgeispower.”Itisalsowritten,“Peoplearedestroyedforlackofknowledge”(Hosea4:8).Lackofknowledgeabouthowthebodyfunctions–and,thus,alackofpropercareofthebody–leadstoitsdysfunctionandalongroadofhealthstruggles,needlesspain,andsufferingforbothyouandyourlovedones.

This document is designed to help equip you to prevent and overcome unnecessary health challenges.



3

A Brief Overview of theGastrointestinal System

Over your lifetime you will ingest approximately 60 tons of food that will ultimately pass through yourgastrointestinal tract.4Thereisnodoubtthatfoodisextremelyimportantforwellbeing,asitprovidesthevitalnutrients that are essential for a healthy life.However, thepassageof this food through yourgastrointestinaltractisalsoapotentialthreattoyourhealth.Digestingfoodintoday’sindustrializedworldof“Franken-Foods”(atermdescribingfoodproductsthatarehighlyrefined,prepackaged,highcalorie,lownutrients,andladenwithchemicals)breaksdowntheprotectivebarrierinyourintestinesandexposesyourbodytoharmfulmicrobessuchasviruses,bacteria,moldsandfungus.Additionally,exposuretotoxicchemicalsresultsinhavocnotonlyinthegut,butalsothroughoutyourentirebody.

Beforemoving forward it is important topointout that theGI tract is a tubeapproximately30-feet in lengthstartinginthemouthandextendingtotheanus.Technically,thistubeisoutsideofthebody,similartothewayaholeinthemiddleofadoughnutisnotpartofthedoughnut.Inthesameway,the60tonsoffoodthatpassesthroughyourgastrointestinaltractisstilloutsideyourbodyuntilitisdigestedandabsorbedintothebloodandtissues.Thesameistrueforthemultitudeoftoxinsandbadmicrobesthatenteryourbodythroughthedigestivetract.Infact,90%ofthebacteriathatentersthebodydoessothroughthemouth,thefirstpartofthedigestivetract.

Thehumanbodyisestimatedtohaveapproximately100trillioncells.However,itplayshosttoroughlytentimesas many microorganisms in the intestines alone.5Thismeans your body has ten timesmoremicroorganisms(bacteria,molds,viruses,etc.)inyourgutthanyoudocellsinyourbody.Itisforthisreasonthatapproximately60-70%ofthebody’simmunesystemsurroundsthegastrointestinaltract.6 The gastrointestinal system is the primary areawereharmfulanddamagingsubstancesgainaccessintothebody.Whenthegutbarrierishealthy,however,thosesubstanceshaveverylimitedaccessintothebody.Whenthegutbarrieriscompromisedandbrokendown,destructivematerialssuchastoxinsandharmfulmicrobesenterthebody.Thismovementofbadmicrobes,toxins,foodproteins,etc.intothebodyiscalled,LeakyGutSyndrome,sometimescalledsimply,LeakyGut,orIntestinalPermeability,orLeakyBowelSyndrome.

Whenthegutbarrierispermeableorleaky,itallowssubstancestoenterintocirculationthatwouldnotnormallybeallowedtopass.Theimmunesystemthenactsasaborderpatrol,allowinghealthysubstancestopassinspectionbutattackinganddestroyingunhealthysubstances.



4

The Widespread Consequences ofLeaky Gut Syndrome

This part of the discussion reveals an often-overlooked cause and effect ofmuch of the chronic disease thatplaguesmankind.Whenanunauthorizedsubstanceentersthebodythroughaleakygutbarrier,thatsubstanceiscalledanantigen.Anantigencouldbeavirus,bacteria,fungus,intactfoodprotein,chemicaltoxin,etc.Anythingthatisforeigninthebodyandthatdoesnotsupporthealthandvitalitycanbedefinedasanantigen.Antigensareabletoenterthebloodstreamfromoneoftwoways:throughtheskin,orthemucusmembranesfrommouthtoanus,asbothportalsofentryaretechnicallyoutsidethebody.Thesetwoportalsofentryaretheonlywayantigens(harmful,foreignsubstances)canenterthebody.Thedigestivetract,bytheway,hasasurfaceareasolargethatifitwerestretchedoutflatitwouldcoveranentiretenniscourt!

Recall thatyouaredesignedwithapproximately70%of the immunesystemaroundyourgut,becausethat ishowmostantigensenterthebodyandpenetrateintothebloodstream.Therefore,ahealthygutbarrierisvitaltooverall health.

Inordertoillustratejusthowimportantthegutbarrieris,let’simagineascreeninthewindowofyourhome;ithasthousandsoftinylittlesquaresallowingentryofonlythesmallestparticlesintoyourhome.Muchinthesameway,ahealthyintestinalliningallowsonlythesmallestdigestedparticlesintothebody,suchasvitaminsandminerals.

Nowlet’simaginethewindowscreensinyourhomeareconstructedlikeachainlinkedfencewithmuchlargerholesthanatraditionalscreen.Thiswouldallowmuchlargerinvaderslikebugs,birds,snakes,spiders,squirrels,etc,intoyourhome.Oncetheseintrudersenteryourlivingspaceyouwouldprotectyourpropertyanddefendyourhomefromtheseforeigninvadersandchasethemoutofyourhousewithabroom.Similarly,whenyourintestinallining isnothealthyandyouhave“leakygut,” largeparticles (antigens)willenteryourbodyandbloodstream.Similar toyouchasingcrittersoutofyourhousewithabroom,yourbodyhas littleguardscalledwhitebloodcellsthatrecognizethebigparticles(antigens)assomethingforeigntothebody.Thewhitebloodcellsrespondbysoundingthealarmandreportingtoalltheirwarriorfriendswhattheforeigninvaderslooklikesothewarriorcells(called,KillerCells)canworktogethertoeliminatetheantigens.Thewhitebloodscellsscantheantigensforits“fingerprint,”so-to-speak.Ortoputanotherway,itcouldbecomparedtoscanningabarcodeonaproductatyourgrocerystorethatidentifiesthespecificproductyouwishtopurchase.Whenthewhitebloodcellguardiansscananantigen,theytelltheimmunecellstoattackanythingthatlookslikethatbarcode.Whilethisisavitallyimportantfunctionoftheimmunesystem,leakygutsyndromecancausethissystemtobecomeconfusedandbeginattackingthehealthytissuesofthebody.Thisiscalled,autoimmunedisease.

Ingeneral,autoimmunediseasesworklikethis:Iftheintestinalliningisleakyandallowslargeparticlestoenterintocirculation,thewhitebloodcellswillrespond4byscanningtheforeigner.Let’simagine,forexample,thattheforeignsubstanceisanintactfoodprotein.Intactproteinsarenotsupposedtobeallowedintobloodcirculationundernormalcircumstances.Proteinsaresupposedtobebrokendownintoindividualaminoacidsbeforetheyareallowedtoentersystemiccirculation.Butifthegutbarrierisleaky,intactproteinscangetpassedthebarrierbeforetheyareproperlybrokendown.Therefore,basedonyourgenetics,iftherehappenstobeproteinsinthethyroidtissuethathaveasimilarstructureandshapeastheintactfoodproteinthatthebodyhasscannedasaninvader,theimmunesystemwillthenconfusethetwoandbeginattackingtheproteins inthethyroidaswell.Thisisonemechanismthatcancausetheautoimmunethyroidcondition,Hashimoto’sThyroiditis.Similarly,iftheinvaderslooklikethenervetissuesitcouldleadtoanattackonthenerves,leadingtoMultipleSclerosis.AndtheexactsameprocessalsoleadstoRheumatoidArthritis,iftheantigenlookssimilartoyourjoints,andanumberofother autoimmune diseases.



5

Areyoubeginningtounderstandhowthisworks?Whentheimmunesystemsendsthewarriorsouttodestroytheinvaders(antigens),ifthoseinvaderslooksimilartoyourowntissues,yourbodymaybegintoattackitself.

Approximately 50million Americans suffer from some type of autoimmune disease.7 This is the number onecondition thatplaguesAmericans.Even thoughmorepeopledie fromheartdiseaseandcancer, interestingly,researchisindicatingthatleakygutmaycontributetocancerandheartdisease.Autoimmunediseasesarethethirdleadingcauseofmorbidity(rateofdisease)andmortality(deathrateofdisease)intheindustrializedworld8, justbehindheartdiseaseandcancerrespectively.Becauseoftheoften-overlookedconnectionbetweenthegutanddiseasesofall sorts,ahealthy intestinal liningcouldpreventandperhapsevencuremuchof thechronicdiseasesthathaveplaguedmodernman.PerhapsHippocrateswascorrect:“Alldiseasebeginsinthegut!”

However, leaky gut does not stop at autoimmune disease; it has been linked to multi-organ system failure,and systemic (whole body) disease and immune dysfunction.9 It has also been associatedwith a number ofinflammatoryconditionssuchasasthma,eczema,psoriasis,andCrohn’sdisease.10

Asyoucansee,anunhealthyintestinalsystemwithleakygutmayleadtoanumberofhorribleconditions.



6

Keeping the Gut Barrier HealthyAt thispoint youmaybeaskingyourself,“How does one prevent the break down of the intestinal lining, leading towards leaky gut allowing bad things to enter into my body?”

Here are three key action steps to keep the gut barrier healthy:

1. Ensureproperdigestionofkeynutrientsthattheintestinalcellsneedtofunctionproperly.

2. Eliminatetoxins(“Franken-Foods”)fromthegastrointestinaltract.

3. Maintaintheidealratioof85%“goodbacteria”(knownasprobioticsand/or intestinalmicroflora)to15%“badbacteria.”11

Maintaining your intestinal microflora is perhaps the single most important step youcan take to protect your health.

Theterm,“probiotic”isacompoundwordmeaning,prolife.Itreferstothetrillionsofhealthfulbacteriathatlinetheintestinaltractandpositivelyaltertheintestinalmicroflorabalancebyinhibitingthegrowthofharmfulbacteria,promotinggooddigestion, reducing toxins, andboosting immune function,whichwill increase resistance toinfections.Whenyouhaveflourishingcoloniesofprobioticsyouarebetterequippedtocombatthedevelopmentofmanydifferentchronicdiseases,includingobesity.12

Speakingofweightloss,nearlyeverystudyperformedthatanalyzedtheintestinalflorainanobesepopulationfoundagreateroccurrenceof“bad”bacteriaandlowerlevelsofbeneficial“good”bacteria.13 There is even a study thatfoundtestsubjectswhoreceivedsupplementalprobioticsdailywereabletoreduceabdominalfatbyalmost5percentover a 12-weekperiod,while thegroup thatdidnot take aprobiotic experiencedno suchpositivechanges.14

Askyourself,“AmIashealthyasIwanttobeorcanbe?”Ifyousaid,“no”,thenitmaybeworthinvestigatingyourguthealthinordertounlockthehealthpotentialofyourentirebody.Evensymptomsthatareminorandmildinnature,suchasfatigue,couldberelatedtoguthealth,sincethedigestivesystemisverycomplexanddemandsmuchenergytofunction.Ifthedigestivesystemisstrained,youwillnotfeelvitalandenergetic.

The Lining In Your Gut Is Actually Part of Your Immune System.



7

Signs that your intestinal dysfunction may be more advanced and that you may have an imbalance of healthy versus unhealthy bacteria, are as follows:

• Gasandbloating • Constipationand/ordiarrhea • Sinus/Allergyissues • Unexplainedmuscleandjointpain • Fatigue • Headaches • Sugarcravings,especiallyforheavilyrefinedcarbohydrates • Unrelentingweightgain • Frequentillness • Depression • Sleepissues

Perhapsyouarelikethemajorityofthepopulation,whichisseverelydeficientingoodbacteria.Therearemanyreasonsthatmaycontributetothisproblem,butmanyofthemarelifestyleandenvironmentalfactorsthatcanbeeasily controlled. These include, but are not limited to:

• Antibiotics:FouroutoffiveAmericansareprescribedantibioticseveryyear,makingantibioticslikelythenumberonecauseofimbalancebetween“good”bacteriaand“bad”bacteria,knownas“dysbiosis.”15Dysbiosisoccursbecauseantibioticsdonotrecognize“good”bacteriafrom“bad”bacteria.Thus,theykillallbacteria,includingthegoodmicroflorathatliveinyourgut.Thiscansignificantlydecreaseyourhealthybacteria,whichmayleadtoanynumberofnumeroushealthconsequences.Evenifyoudonottakeprescriptionantibiotics,they can still influence your health, as they are in products you ingest regularly, such as commercially raised meatsanddairy,bothofwhichtendtobeladenwithantibiotics.Thisalonecandisruptflorabalance.

• NSAIDS: Abusing non-steroidal anti-inflammatory drugs to alleviate pain such as Aspirin, Advil,Indomethacin,etc. inhibitsgrowthofhealthyprobioticbacteria,whichcancauseabacterial imbalance inyourintestinesleadingtoleakygut.

• Sweeteners:Sweetenersofanykind,includingartificial,altertheactivityoftheintestinalfloracausingadisruptioninthebalanceofgoodtobadbacteria.16

• Processed foods: An overgrowth of fungus and yeast can be caused by a diet high in refinedcarbohydrates,thusleadingtoanovergrowthoftheunhealthybacteria,fungus,andyeast.17

• Agricultural chemicals and pesticides: Nearly all commercially available fruits and vegetables aretreatedwithpesticidesandherbicidesandarenearlyimpossibletoavoid.

Thisshort listof justfive lifestyle factors isbynomeansexhaustive,but just thesefivearesoprevalent inourculturethattheyarealmostcertainlyimpactingyourhealthrightnow.Therefore,itisalmostcertainthatyourgutflorabalanceisaffectedandwillcontinuetosufferunlessyoubecomeproactivetocorrectitonadailybasis.Infact,manyresearchersandhealthproviderssuggestthatsupplementingwithprobioticseverydaycanbemoreimportanttoyourhealththantakingadailymulti-vitamin.



8

But before you just go out to buy a probiotic product,there are some things you must know.

Not all Probiotics are the SameDue to theextremeacidicenvironmentof the stomachand the releaseofbile from thegallbladder, researchindicates that anywhere from 80-99% of traditional unprotected live probiotic cells will be killed off beforereaching the intestine.18Inorderforthegoodbacteriatoprovidetheirbeneficialeffectstoyou,theymustbeabletowithstandprocessingconditionsandalsobeviableinsufficientnumbersduringstorage.19Traditionalprobioticsupplementswillclaimbillionsofactivecellsperdoseontheirlabels,buttheydonotpromisetheyarealiveandwellastheyenteryourintestines.Somecompaniesclaimtobesuperiorwithaprocesscalled,“microencapsulation,”thatissupposedtoshieldtheprobioticsfromthedamagingeffectsofthestomachacid.

However,researchindicatesthatnoneofthesereportedmethodshaveresultedinshelf-stable,viableprobiotics.20 Thebottom-lineisthatthemostexpensivesupplementistheonethatdoesnotwork,asitpreventsyoufromreceivingthevitallyimportanthealthbenefitsthatmotivatedyoutopurchaseaprobioticproductinthefirstplace.

Fortunately,thereisasolution,andtheanswerliesinanexclusiveproprietarynaturalfermentationprocess.AtHumarianResearch Lab,wehavedeveloped themost advancedandeconomicalprobiotic formula anywhereon earth, Probonix.Thisproductisnotaboutalabelthatclaimsbillionsuponbillionsofactiveandlivebacteriathataredeadbeforetheyreachtheintestines.Probonixisabouteffectiveness,asithasbeendevelopedusingacutting-edgefermentationtechnologydevelopedbyresearcherstodeliverstableandviableprobioticbacteriainto your intestines.

Insteadofputtingbillionsofprobioticbacteriaintoapillandhopingsomeorganismsmakeittotheintestinesalive,we atHumarian focus ongetting theorganisms into the intestines safely and effectively.This exclusiveproprietaryprocessprotectseachlivecellfromtheharshbileandstomachacid.Similartohowaspecialcoatingprocessisusedformanymedicationsthatpreventthedrugsfrombeingactivateduntiltheyreachthesmallintestine,Probonix is saturated in a solution that places the individual bacteria in atemporary static state and protects them against the stomach acid. Only after they reach the intestines do they becomeactivated and provide their many health benefits. Once theorganismsinthisproductreachtheintestines,theyawakenfromtheirstateofhibernationandmultiply innumber,proliferatingthroughout the entire intestinal tract. This process dramatically enhances the survival and growth of bacteria over traditionalprobiotic supplements, since all other probiotic products relyon traditional encapsulation and not fermentation. Therefore,Probonix isthefirstandonlyprobioticproductofitskind.

Inadditiontocreatinganindustry-firstinmaximizingbacterialcolonizationinthegut,Humarian Research Lab has pioneeredthenutraceuticalindustry’sfirstfermentedToxin-ScavengingLactobacillus.Ourexclusiveproprietaryformulausesaunique,butnaturallyoccurringfermentationprocessthatallowsnaturalandbeneficialchangesto thebacterium’s cellwall.During thisprocess thebacteriumare trainedby repetitivepassagesof increaseddosesofmixed toxins frommold (mycotoxins) andother toxic substancesbound to“bad”bacterial cellwalls,calledendotoxinsalsoknownasLipopolysaccharides(LPS),thatarereleasedwhenthebadbacteriumrupturesordisintegrates.ThestrainsultimatelyselectedfortheHumarianproductthriveinatoxin-challangedenvironment,thustheyinherentlyseekanddestroytoxins.TheseeffectsarepartoftheToxin-ScavengingLactobacilli’sinnatebiologicalcapacities.ThisexclusiveproprietaryprocessallowstheToxin-ScavengingLactobacillustoeasilyeffectthetiniestandhardest-to-reachspaceswithoutaffectingitsfunctionalcapacity.



9

Humarian Research Lab has includedanextraordinaryblendof12 extremely unique probiotic strains not containedin99%ofotherproductsonthemarket.And,yes,anumberofthemarenaturallyresistanttostomachacidandbile.These12include:10

• Lactobacillus plantarum L.plantarummayreducegrowthandpenetrationofforeignbacteria(includingLPS),viruses, funguses,andmoldwhileprovidingprotectiontothenervoussystemfrommold toxins.21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36

• Lactobacillusrhamnosus Resistanttogastricacidandbile,L.rhamnosusstronglyadherestotheintestinalwall,whichmay beimportantforcompetitionwithunhealthybacteria,stimulationofmucousproduction,andthe possiblemodulationoftheimmunesystem.Itprotectsandmaintainstheintestinalbarrier,andmay inhibitgrowthofintestinalpathogenssuchasmoldsandfungus.Itcoulddown-regulateinflammatory responsesandmaybebeneficialincasesofacuteinfectiousdiarrheainchildren.L.rhamnosuscould provideadjuvanttherapyforH.pyloritreatment(H.pyloriisabacteriaassociatedwithulcers).It couldalsohelpmanagesomesymptomsofirritablebowelsyndrome.37,38,39,40,41,42,43,44,45,46,47,48,49,50

• Bifidobacteriumbifidum Thisbacteriumisthepredominantspeciesintheintestinaltractofbreast-fednewborns.Itcompetes withpathogensforadhesiontotheintestinalcells,andmaybeneficiallymodulatetheimmune system.Itmaystronglydown-regulateinflammatoryresponses.Bifidobacteriahavealsobeenshown tohelpinthemanagementofchronicconstipationandallergysymptoms.Itenhancesnutrient absorption,particularlyB-vitaminabsorption,andoptimizesdigestion,maintainingahealthy balanceinthecolon.51,52,53,54

• Bifidobacteriuminfantis Thisspeciesofbacteriahasbeenthefocusofresearchpertainingtothetreatmentofacuteinfectious diarrheainchildren.Itmayhelpwithsomesymptomsofirritablebowelsyndrome,asithas shownresistanceagainstvariouspathogenssuchSalmonella,andmayprovidebenefitinprotection against gastroenteritis.55,56,57

• Bidifobacteriumlongum Thisbacteriumisknownforitsabilitytosupportguthealth,decreasinggutinflammation,and supportingimmunehealth.Resistanttostomachacidandbile,B.longumbindstohumanintestinal mucus,preventingentranceofunwantedsubstancesintothebody.Accordingtoscientists, Bifidobacteriumlongumisamongthefirstcolonizersofthesteriledigestivetractofnewbornsand dominatesinbreast-fedinfants.Itinhibitsgrowthofintestinaltoxicbacteria,andmaystronglydown- regulateinflammatoryresponses.Ithasalsobeenusedsuccessfullyinclinicaltrialsontheprevention ofrelapseinulcerativecolitispatients.Additionally,itproducesimportantBvitamins,providing benefitstothecardiovascularsystem.Itmayalsobeusefulinthereestablishmentofhealthyvaginal flora.58,59,60,61,62,63

• Enerococcusfaedum Thisbeneficialbacteriaiseffectiveatrelievingdiarrheafromacuteinfectionsinthegastrointestinal tractordiarrheacausedbyinflammationinthegastrointestinaltract.64,65

• Lactobacillusacidophilus Beneficialinnegatingthetoxiceffectandgrowthofmold,yeast(Candida),andparasites,thisspecies ofbacteriaishasalsobeenusedasanadjuvanttreatmentduringchemotherapyandprovesbeneficial inthetreatmentofacuteinfectiousdiarrheainchildren.66,67,68,69,70,71



10

• Lactobacilluscasei Lactobacilluscaseihasbeenshowntohelpmanagechronicconstipation,72isalsoadvantageousin managinglactoseintolerance,andmaysupporttheimmunesystem.73Itcouldbeusedasan adjuvanttreatmentduringchemotherapy,74andmayalsohelpwithdiarrheaassociatedwith antibioticuseandvariousbacterialinfections.75,76

• Lactobacillushelveticus L.helveticusisresistanttogastricacidandbile.Itstronglyadherestointestinalcells,whichhelpsto maintaintheintegrityoftheintestinalbarrier.Someofitsmanypotentialhealthbenefitsincludethe inhibitionofpotentialpathogens,supportinghealthybloodpressure,andbeneficialmodulationof theimmunesystem.Itmayhelpinimprovingsymptomsoflactoseintoleranceandhelpingto preventandreducethedurationofdiarrhea.Ithasbeenshowntoenhancethebioavailabilityof nutrients,removeallergensandotherundesiredmoleculesfromfood,andaidinprotein digestion.77,78,79,80

• Lactobacillussalivarius Knownforitsoralhealthbenefits,L.salivariushasbeenshowntodramaticallydecreasethelevelof plaqueformingbacteriainthemouthwhilenaturallyfresheningbreathandreducinggumsensitivity. Additionally,itmayinhibitthegrowthofH.Pyloriinthedigestivesystem.81,82

• Pediococcusacidilactici Veryresistanttodestructionbystomachacids,animalresearchhasshownthatP.acidilacticiisable tobalancetheintestinalbalanceofbacteriaandthusstrengthenoverallhealth.Currentresearch indicatesthatP.acidilacticiisabletopromoteahealthyinflammatoryresponseintheintestines,as well as support a healthy immune response. P. acidilactici produces several compounds that reduce thenumberofunhealthybacteriaandparasites.Specifically,itisknowntopreventtheoccupation ofthesmallintestinebyunhealthybacterialikeSalmonellaandE.coli.Additionally,researchindicates apotentialsupportiveroleinpatientswithMultipleSclerosis.83,84,85,86,87,88

• Streptococcusthermophilus Thisstomachacidandbileresistantbacteriabeneficiallymodulatestheimmunesystemand competesagainstunhealthybacteria.Additionally,S.thermophilusmayreducethefrequencyof colicininfantsandmaybenefitthosewithlactoseintolerance.89,90,91,92

Obviously, Probonixisnotanordinaryprobiotic.Basedonscientificresearch,universitystudies,andfieldtrials,thisproducthasbeenshowntoprovideaplethoraofhealthbenefits,asummaryofwhichinclude:

1. Supportofthenaturalgrowthofbeneficialbacteriaintheguttofurtherimprovetheratioofhealthy probioticbacteriatounhealthypathogenicbacteria.AprivatestudyattheUniversityofWisconsin revealedasix-foldincreaseinthecolonizationofLactobacillithroughoutthewholeintestine.

2. Enhancementofthenaturaldetoxificationprocessbyup-regulatingkeyregulatorymechanismsinthe bodythatnormallypreventtoxinentryintothebody.Theprobioticbacteriaaretrainedtointerceptand destroytoxinsintheintestinalwalllining.Inadditiontothetoxic-scavengingeffect,thebacteriumalso bindsuptoxinstobeexcretedinthefeces.

3. Modulationoftheimmunefunctionbydown-regulatinginflammatoryresponsesandup-regulating antigenrecognitionandantibodyproduction.

4. Inhibitionofthegrowthofunhealthybacteria,astheacidproducingcapabilitiesoftheprobioticbacteria areenhanced.Thisenhancedacidproductioninthegastrointestinaltractsuppressesthegrowthof organisms in the gut such as Salmonella, E. coli, etc.

5. Improvementofdigestion,enhancementinthebioavailabilityofnutrients,andreductionofdairy intolerance.

6. Supportoftheregenerationofcellsinthegutlining,andprotectionofthegutlining,showingpromise inthesupportofconditionsassociatedwithLeakyGutSyndrome.



11

Probonixismanufacturedtobeallergen-free;itcontainsno

WHEAT GLUTEN

SOYBEANS EGG

FISH/SHELLFISH PEANUTSORTREENUTS.

Probonix hasbeen reportedbyusers tohelp andassist in themanagementof the following conditions andsymptoms:

Sinus symptoms • Congestion • Nasaldripping • Allergicreactions

GI tract disturbances • Bloating • Ulcers • Pain,cramping,andinflammation • Constipation • IntestinalPermeability(LeakyGut)

Genitourinary (reproductive organs and urinary system): • Vaginalyeastinfections • Urinarytractinfections Inflammation • General • Localizedtoaspecificarea

Autoimmune conditions • Alltypes

Skin conditions • Alltypes



12

You have nothing to lose!Becausetherearenospecifiedstandardsofquality,effectiveness,orsafetybytheFDAwhenitcomestoprobioticproducts,manyproductsonthemarketprovidelittle,ifany,healthbenefits.Infact,areportbytheJournaloftheAmericanMedicalAssociationon60commerciallyavailableprobioticproductsshowedthatmostof themdidnotevenmeetlabelclaim.Throughanexclusiveproprietaryprocess,however,Probonixdeliverspowerfullivebacteriatothegut.

Probonix is perhaps the most unique and effectiveprobioticonthemarketbecauseitisinaclassofitsown.NootherprobioticmanufacturerhasmasteredthetechnologycurrentlybeingutilizedbyHumarian Research Lab, andthosewhohavetriedtoreplicateithavefailed.

Youandyourlovedonesdeserveaccesstothebestprobioticproductsonthemarketinordertoachieveoptimalhealth.ClicktheAddtoCartbuttonnowtobeginexperiencingthemanyhealthbenefitsprovidedbytheexclusiveproprietary ingredients in Probonix.Onelargebottleisatwo-monthsupply.Simplytakefourdropstwiceperdayandstartyourpathtoachievingthehealthyouandyourfamilydeserve.

100%SatisfactionMoney-BackGuarantee.Ifatanytimeinthefirst30daysyouarenot100%satisfiedwiththeproduct,simplyreturnitandwewillrefundyourmoney.You have nothing to lose. Just take 4 drops twice perday and let nature do the rest.

*The statements in this booklet have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

“I took one drop before bed and woke up the next morning and was able to walk…”

“I’ve had a long series of digestion issues that started when I was in college, and it made a huge difference for me.”

“I was on several different things for my indigestion… I don’t take anything anymore and I’m feeling really good.”

“I had a lot of GI issues… I was on double dose Nexium, Axid and now I’m off of all those…”

REALCUSTOMERTESTIMONIALS



1

MoreProbinixTestimonials Ihave suffered,and IdomeansufferedwithLupus for12years.Mydoctor recommended that Iuse thisprobioticasitbringsbalancetoanoutofcontrolimmunesystem...FatigueGone!.IamdoingthingsIhavenotbeenabletodoforyears.IamsothankfulthatfinallysomethinghashelpedandIfeellikemyoldselfagain.Iwholeheartedlyrecommendthisproduct.-D.Johnson

Iboughttheone-monthsupplytogivethisproductatry.HadIknownhowmuchbetterIwouldfeelIwouldhaveboughta2monthsupply,soIthoughtIwouldpostthishereaswellincaseithelpssomeoneelse...Iwishtheyofferedayear’ssupply!

I have suffered from stomach issues since the removal ofmy gall bladder 7 years ago. Bloating and extremediscomfortespeciallyaftereatingwerejustpartofanormaldayforme.MycoworkersoftenteasedmesayingitIlookedlikeIgotpregnantatlunch.Ihavetriedmultipleprescriptionsandhavehadmystomachscopedseveraltimesonlytobetoldthatit“wasinflamedandhereisadifferentprescriptiontotry.”

Aboutayearago,Istoppedallprescriptionsandmodifiedmydiet-Ibeganeatingaveryclean,freshfooddietwithnoglutenorbreadsandstillhadthesameissues.IwascomingtotermswiththefactthatIwouldneedtolivewithit.Afriendofminesuggestedprobiotics.IwashesitanttotryanythingelsebutafterdoingsomeresearchIdecideditwasworthatry.IhappeneduponProbonixandwasimmediatelyimpressedwiththeproductandthecompany.Beingnaturalandglutenfreewereveryimportanttomeasistheircommitmenttohighquality.

Well IwasevenmoreimpressedwhenIboughtsomeandstartedusingit.WithininaweekInoticedchanges.TomakesurethatIwasn’timaginingitorwillingittobeIhadmysonstartusingit.Heeatsveryhealthyandliftsweightsandoftensuffersfromthesideeffectsofprotein(akaprotein“gas”).Iamalmostmorethrilledwithhisresultsthanmyown.Hewasn’ttheonlyonethatsufferedfromhisgas!

ThelongerItakethisthebetterIfeel. Ihavesolittlebloatinganddiscomfortnowjust4weekslaterthatIcanimaginethatsoonIamgoingtohavedayswithoutany!IseemyselfusingProbonixfortherestofmylife.Idon’twanttogobacktofeelingawfulagainnowthatIhaveachoice.ThankyouHumarianResearch-ifIeverymeetanyofyouinpersonpleaseknowthatIamgoingtohugandkissyou!-StephanieJeffreys

Iwaswakingupinthemorningslikearthritiswasthroughmybody,gotsomebloodworkdoneandfoundoutIhadathyroidproblem,Docputmeonthisliquidprobioticwithanotherallnaturalformythyroid,thepainhasleftmybody90percent.SoIwillcontinuetotakeit.-Dolly

I love thisproduct, especially the liqued form, just fourdropsunder your tongueandyouaredone.Theflavorisgrape,buttasteslikesweettartscandy.Italsohasauniqueblendofpro-botics,andhasallyouressentialminerals,likemagnesium,maganese,seleniumpotassiumandmore.soitisgreattouseeveryday.Theyjustdon’ttelltheamountsofeverythinglistedonthelabel.ButIplantobuyagain.-AmazonCustomer



1

Absolutelygreat,really.Normaldigestionforthefirsttime!Completelycuredmylifelongconstipation.Allstraining,pushing,feelingcrampy,notgoingfordays(uptoaweek)isgoneandnowIhavenormaleliminationforthefirsttimeinmylife.Forthoseofyouwhosufferthesame,itwouldbeworthitforyoutogiveitashot.Inowknowwhatanormalbowlmovementfeelslike!Inaddition,mypoochinthelowerabdomendisappearedthefirstdayonthisproduct.Itake12-18dropsperday.-I.Thompson

Ireallylikethisprobioticproduct.I,too,startedwiththesmallersize.Immediately,IwishedIhadorderedthelargerbottle.(Thinkanotherreview–whomIdonotknow–saidsomethingsimilar.Ihadsameexperience.)

I’vebeenaroundtheblockwithregardstoprobioticsofvariousforms.Ieatfermentedfoods,havemade/stillmakemyownyogurtandkefir,etc.Ihavenoticedvariousissueswithmybodyimprove.However,itwasn’tuntilIstartedusing concentrated liquidprobiotics that certain issuesgreatly improved. I’ve tried a couple liquidprobiotics.(Noneof these are available in stores.Had to order them…noton amazon, either.) Eachoneuses a differentprocessandthelookandtasteofeachoneisdifferent.HoweveroftheonesI’vetried,Ilikethisonebest.Nogluten(oneproducthadthat),norefrigerationneeded(bigplus),greatpriceandtastesgood!(Myyoungestevenlikesit!Wasn’tthecasewiththeotherswetried.)

Bytheway,Iusemorethanthelabelsuggests.Asapersonwho’sbeendoingfermentedfoodsandprobioticsforawhile,Idon’trecommendthatothersnewtosuchaproducttakemypath.Itisbesttostartasthelabelsuggests,andlistentoyourbody.Keepinmindthat“dieoff”[ofthe“bad”bacteria]iscommonandmightcauseonetofeelnastyeffects.Reduceyourdoseforawhile,andletthe“reaction”subsidebeforeaddingmoredrops.

I’manathleteanddosomelong‘workouts’inmysport.Twoyearsago,Ihadahealthchallengemanifestthatmadeitextremelydifficultandverypainfultoparticipateinmysport…evenatverylowlevels.(Noendurance,strengthevaporated…andsodidmy“everydayenergy”.Plus, recovery took forever!) I’ve found that thisproduct reallyhelpsmeagreatdeal.I’verunoutbyaccidentacoupleoftimesandfoundthatI’ddoabackslide.Oncetheneworderarrivesatmydoor,2-4dayslaterIamanewperson.

I’mstayingwiththisone!-CloudGazer

This ismy second bottle of Probonix and I am very happy that I started using this probiotic. I was toldprobioticswouldhelpmystomachissuesandtriedseveralovertheyearsbutnevernoticedadifference.TheonesthatneededtoberefrigeratedandIthoughtshouldsomehowbemoreeffectivejustweren’t.Lovethatthisisaliquid,lovethatthere’snorefrigerationrequiredandIcanthrowitinmypurseandtakeitwithme.It’sagreatideaandI’mgladsomeonefinallycameupwithit!Inolongerhavetotakethat“littlepurplepill”everydayandIlovethataswell!-GrammyR

I love Probonix! I’veneverbeen regular until I started this product. I’ve triedotherprobiotics and theyneverseemedtoworkandtastedterrible!Soexcitedandhappytohavefoundthis!I’vebeentellingeveryone:)ProbonixisdefinitelyaMUST!-T.Johnson



1

Easy travel size, no refridgeration andmakes a hugedifference inmydigestion.Was recommendbymyFunctionalMDandI’venotfoundanythingbetteronthemarket.-D.Dernberger

Excellent product! It has been helpingmy son who has autism. More talkative, focused, observant andinteractive.Othershavenoticedtheimprovementaswell!ProbonixisthemiracleIhavebeenhopingfor.Hemixesitinhisicedteaeveryday.Itisalsohelpingwiththechronicconstipationhehashadsinceinfancy.IhavetriedmanyotherprobioticsonhimbutProbonixistheONLYonethathasworkedthiswellandwithoutanystomachcramps.Pleasedonotstopmakingthiswonderfulproduct!-DonnaD.

Ihaveusedthisproductsuccessfullyforaboutayearnow;Iappreciatetheconvenienceofbeingabletotakemyprobioticsinaliquidform,thatisnodoubtmorebio-available.LatelyIhavebeenadding6dropsto2ouncesofpurealoejuiceeveryevening.Thetightnessinmystomachandoccasionalgaspainsareallbutgone.Asprobioticshavealsobeenshowntoassistpeoplewithasthma,Ihavenoticedamuch-decreasedneedtousemyinhaler.Ihavenoreservationsaboutrecommendingthisproducttoothers,andhavedonesoonmanyoccasions.-MidwestMom

ProBonixhasbeenatrueblessingforbothmysonandme. Wehavebothsufferedfromsevere“seasonal”andotherallergies(treatedwithbothprescriptionpillsandnasalsprays)alongwithchronicreflux(bothofuswereondoubledosesofNexiumdaily).ThankstoProBonix,wearebothnolongertakingrefluxorallergymeds(alongwithalltheiryuckysideeffects;ugh,thedrymouthanddrynasalpassages!).Can’tsayenoughgreatthingsaboutthisproduct. ThanksProBonixforthe“healing”ofourgutwhichhasbeenhugeforouroverall/wholebodyhealingprocess!-KellieS.

Iamsothankfulforthisamazingproduct!Ihavestruggledwithawheatallergyforseveralyears,missingoutonsomeofmyformerfavoritefoods,notbeingabletotrynewfoods,andworstofallalwayshavingtoreadthelabelsbeforebuyinganything.SincetakingProbonixIamabletoenjoyfoodslikepizza,andcanhavebunsonmyburgersagain!Iamorderingmoreformyselfandsometogivetomyfamily.-A.Huskins

Thisproduct isveryeffectiveandeasytotake. Iboughtthe1-monthsupplyformyhusbandandhe likesthatitdoesnothavetoberefrigerated.Itispackagednicelyandarrivesquickly.Werecommendthistoallofourfriends.Myhusbandfeelsit’sagoodpricepointforwhatyouget.SincetakingProbonix,hehasfeltlessbloated.Greatproductandwelookforwardtobuyingthe2-monthsupplysoon!-M.Marcum

Thisprobioticisgreat!easyandquicktousefoemyselfandmy2yearold.Idogothroughsomehealingcrisiswithit(whichisgreatandhowIknowit’sworking)andIhavealsobecomevery“regular”with5star#2’s:o)LOL.Highlyrecommended!-Lucia



1

Ihavebeenwantingtotryaprobioticandthistwomonthsupplyisagreattrialsizetoseehowitworks!Ilikethatthisisinliquidformandthere’sisnorefrigerationrequired.Sofarithasbeenworkinggreatformystomachproblemsaftereating.-NikkiG

Iboughtthisformyentirefamilytouse.Iuseiteverydayatleastonceaday,andmoreifmystomachisupsetfromsomethingIate.Inoticeitreallycutsdownongasandbloatingevenaftereatingthingsthatusuallygivemestomachupset.-Tkolive

Ihadseveralissuesthroughouttheyearanddidn’tunderstandwhy.IateanddrankeveryyogurtIcouldgetmyhandsonbutnopositiveresults.Afterthis,I’mnevergoingbacktoanotherprobioticagain.Period.Musthave.-Lexi

Ihavepurchasedthreetimes.wegivetomy6montholdgranddaughterwhohadcolicanditseemedtohelpwiththecolicandnowwejustthinkaregulardailydoseisbetterforimmunesystem.-K.Richards

AWESOME!NowIknowthatIhavehealthierdigestivesistemI’vebeenonitforoversixmonthsIfeelstrongerandevenlighterbecauseIlost10pounds,thankyou.-W.Latorre

Greatproduct.Goodenergyandhelpswithregulationofdigestion.Economicalandeaseoforderingmakethissomethingtorecommendtofamilyandfriends.-R.Preston

Boughtthisformywifewhohasstomachproblemsandshenoticedadifferencerightaway.Wewillcontinuetobuythistohelpherdigestivesystem.RandyVDV

Igiveittomy4montholdandhelovesit.Afewweeksagoeveryoneinthehousehadacoldexcepthimbecauseofthisstuff.-G.Alexander

BestprobioticIhavefound,plusitiseasytogivetochildren--nopowderorpilltogive,justafewdropsaday.-E.Raess

Beentakingforoveraweekandreallyfeelthedifferenceinmytummy<3soeasytotakeandtastesgreat.-M.Egan



1

Iwasdiagnosedwithautoimmunediseaseandmultiplechemicalsensitivities25yearsago.Takingprobioticshasbeenabigpartofmyrecoveryandhealthmaintenance.IhadcometoacceptjointpainandallergicsymptomsasnormalandthebestIcouldexpect.Afteraseriousboutofjointinflammationandpain,myDoctorgavemeabottleofProbonixtotry.Iwasshockedandoverjoyedtoawakenthenextdaywithalmostcompletereductionofinflammation,allergyreactionsandpain!Iamnowatotalbelieverinthefactthatahealthygutleadstooverallhealthinallsystemsofthebody!Thisisthebest,mosteffectiveprobioticthatIhaveeverused!Iwillneverbewithoutit!-JanetG.

Easytotake,tasteisgood;Iprefertheliquidform,sothisisagoodchoiceforme.-Rebecca

ThisistheonlyprobioticthatIhavefeltarealdifferencewith.Greatproduct.-K.Mollman

Amazing!Helpwithdigestiveproblems.LovethatIcancarryinmypurse.-Smile

Beenagoodprobioticforacidreflux.Helpfulwithotherthingstoo.-M.Brooks

I thoroughlyenjoyusingthisproduct.TheonlyoneIknowtohealmybodyfromtheinsideoutandIamgrateful.WhenIdonottakethetwodropsinthemorningandtwodropsintheevening,InoticeadifferenceinthewayIfeel-bloated,increasedacidreflux,andfatigued.Ireapfromthebenefitsbytakingfourdropsaday,whereotherproductsIneedmoreandmorewithoutasmanybenefits.Itisawin-winforyou!-BarbraB.

IhavebeenbattlingLymeDiseasefor5years!PartofmyholistictreatmentincludeshighqualityProbiotics.AfamilymemberintroducedmetoProbonixlastyear.ItookittomyMedicalDrwhopromptlytestedmeandwasamazedhowwellIrespondedtoit!Sixmonthslater,IstilltestwellandamverystablewithProbonix.Itcontinuestobeanimportantpartofmytreatment!Sogratefulforthisproduct!!-SharonD.

Clearedasinusinfectioninjustafewdays.Thisstuffisgreat!-Lpj

Idon’tfeelasgassywhenItakethis...whichisapluslol!-A.Greenwood

Iusethisinmytoddler’swaterbottle.Sheisverypickyabouttheflavorsofthingssoputtingtwodropsofthisinherwaterbottlehelpshertogetherprobioticswithoutnoticingtheflavor.Ithasalsohelpedtoclearupanissueshewashavingwithloosestools.IuseitsometimestoobutIdon’tputmineinwater,thetastedoesnotbotherme.IwillbeorderingmorewhenIrunout.-Turkette



1

Greatproduct,Itworkswonderseasytotake,mynewmusthaveprobiotic.-J.Matthis

Thisprobioticdoesn’thave tobe refrigerated. It isveryeasy to takeaswellasveryeffective.Wasagreatrecommendation.-Suzie

This product is effective. I am an IBS sufferer and this helped ease my symptoms. I will continue using this product-V.Kucharova

Iput2dropsintheirmorningjuiceandtheyaregoodtogo.(Nopunintended,butitcertainlyhasmadethemmoreregularinthegodepartment.)Iwasgivingthemchewablekidsprobioticsandtheyhatedthem,butnowtheydon’tevenrealizedtheyaretakingthem!-L.Strehle

Thisisanawesomeprobiotic.-KK

IdidhaveCandidabuthadgottenthroughit,andIhadbeentakingaprobioticforaverylongtimeandIhadfoundonethatwasworkingwell.MyfriendrecommendedthisonesoItrieditandandiimmediatelysawimprovementinhowIfelt(surprisingbecauseIwasdoingfairlywell).AbouttwoweeksorsolaterIwentthroughadetoxand saw thatmybodywas“cleaninghouse”...alsoa little surprising,but I cameouton theother sideimprovedandIamsohappywithit.Itisveryconvenientandeasytotake,doesn’tneedrefrigeration,camequickly,packaginglookedgoodandithasmorethanliveduptotheclaimsaboutit.IHIGHLYrecommendit.-GrandmaD

Thisstuffisablessing!Whenmy5montholdstartedeatingcerealshegotreallybackedup.Iputthisineachmealandshegoeseveryday:)-Ashley

Thisisgreatforpeoplewhodonotdowellwithpills.ThisisrecommendedtorelievethesymptomsofIBS.-S.Sparks

Goodproduct-D.Grimes

IamonmysecondbottleofProbonix.ItisabsolutelyAMAZING!Ihavebeensufferingfrombeingconstantlybloatedforyears.Itcausesalotofgasifyouhavealotofbadbacteriainyourgut.WhenIwasonmyfirstbottleIwasunbelievablygassybutstuckwithit. It isnowsubsiding. Idefinitelyfeelbetter.Norefrigerationisaplus,awesomesize,bestshelflifeandcompletelyconvenient.-zachattack

Greatproduct!Easytousewithmyyounginfantwithdigestiveissues.-S.McLane



1

Iusedtogetindigestionandbloatedinmybellyeveryevening,butsincetakingmyProbonixINoLongerhavetheseissuesadditionallyIdon’tgetsickasoftenanymoreandIhavelost45lbs!!!ThisistheBESTProbioticIhavefoundonthemarketandIhavetriedmany.Thisiseasytouseandconvenientifyoudon’tlikeswallowingpills-RoderickB.

Supereasytouseandperfectformyinfant.-E.Bracke

Excellentproduct.Thiswasare-order.-C.O.Lindert

Thisstuffworkslikemagicformyson-Jon“J”

Worksonmy2monthold-Cayla

THANKS-K.Price

This stuffworks sogood! I take it asdescribed4drop twiceaday. Ihaveceliacdiseaseandhavealotofdigestiveissuesandthisstuffhaschangedmylife.Ihavejustreorderedagainandwillcontinuepurchasing!-Candy

Thisisanamazingproduct!Ihavetriedthemost“acclaimed”and“best”onAmazonandothermarketplaces,butthisonebyfarexceededmyexpectations.Nobloating,nonausea,nodiscomfort,itisjustfastandeffective.Thankyouforcreatingsuchandamazingproduct!-K.Staykova

IusedProbionixfor2months.Mixeditintoliquidsandcouldnottasteit.IhavehadpastIBSassociatedissues,andthisproductworkedasadvertisedonthosesymptoms.Theyreallyvanished,anditwasverysimpletouse.Butthebestpartisthenoriskmoneybackguarantee,andthedesireofthesellerforthebuyertobesatisfied.Idon’tsupposethereisanythinginthisworldthatworksexactlythesamewayforeachperson,sothefactthattheystandbehindtheirproductifyouaren’tsatisfiedmakestryingitaneasydecision.Evenifitdidnotworkforme,Iwouldhavebeensatisfiedwiththecompanyforthatreasonalone.Theyareavailabletoanswerquestionsandtrulywantyourfeedbackandtoknowtheresultsyouexperienced.-John

Ipurchasedthese liquidprobiotics formystep-fatherwhoishasoralcancer.AfterbattlingtworoundsofC-difitwasrecommendedthathetakeprobiotics.Swallowingpillsorcapsuleshasbecomeverydifficultforhim,sotheProbonixliquidformhasbeenagodsend.HeispresentlytakingantibioticsforaseparateinfectionbuttheProbonixseemstobestavingoffanotherroundofC-dif.IHIGHLYrecommend!-KofOregon



1

Thisisagreatproduct!Inoticeditseffectivenesswithinthefirst48hoursofusing.Digestion,assimilationandeliminationallimproved.AsaresultmychronicpostnasaldriphaslessenedandIfeelgenerallystronger.-Judy“DallasCoffeeMaven”

ThisProbioticworksreallygood!Itakeitasdescribed4droptwiceaday.Iusedtogetindigestionandbloatedinmybellyeveryevening,butsincetakingProbonixINoLongerhavetheseissues.Thankyou-R.Zerpa

Thisproductisveryeffectiveandeasytotake.Iboughtthisformyhusbandandhelikesthatitdoesnothavetoberefrigerated.Itispackagednicelyandarrivesquickly.Werecommendthistoallofourfriends.Myhusbandfeelsit’sagoodpricepointforwhatyouget.SincetakingProbonix,hehasfeltlessbloated.Greatproduct!-M.Marcum



13

References1. GershonMD.TheSecondBrain:AGroundbreakingNewUnderstandingofNervousDisordersoftheStomachandIntestine.HaperCollins,NY,1998

2. MulakA,BonzaB.IrritableBowelsyndrome:amodelofthebrain-gutinteractions.MedSciMonti.2004;10(4):RA55-RA62.

3. SultMD.TextbookofFunctionalMedicine:Digestive,Absorptive,andMicrobilogicalImbalances,Chatper24,pg330-331

4. BrandtzaegP.Currentunderstandingofgastrointestinalimmuno-regulationanditsrelationtofoodallergy.AnnNYAcadSci.2002;964:13-45

5. BjörksténB,SeppE,JulgeK,VoorT,MikelsaarM(October2001).“Allergydevelopmentandtheintestinalmicrofloraduringthefirstyearoflife”.J.AllergyClin.Immunol.108(4):516–20.·GuarnerF,MalageladaJR(2003).“Gutflorainhealthanddisease”.Lancet361(9356):512–9.·SearsCL(October2005).“Adynamicpartnership:celebratingourgutflora”.Anaerobe11(5):247–51.·SteinhoffU(June2005).“Whocontrolsthecrowd?Newfindingsandoldquestionsabouttheintestinalmicroflora”.Immunol.Lett.99(1):12–

6. 6SalminenS,BouleyC,Boutron-RualtMC,etal.Functionalfoodscienceandgastrointestinalphysiologyandfunction.BrJNutr.1998;80:S147-S71

7. Tobias,L.,ABriefingReportonAutoimmuneDiseasesandAARDA:Past,Present,andFuture,2010

8. Arnson,Y.Amital,H.,andShoenfield,Y.2005.VitaminDandAutoimmunity:Newaetiologicalandtheraputicconciderations,JofImmunology175:4119-26

9. DeMeoMT,MutluEA,KeshavarzianA,TobinMC.Intestinalpermeationandgastrointestinaldisease.JClinGastroenerol.2002;34:385-96

10. CooksonW.Theimmunogeneticsofasthmaandeczema:anewfocusontheepithelium.NatRvImmunol.2004;4:978-88

11. Tannis,Allison.ProbioticRescue:Howyoucanuseprobioticstofightcholesterol,cancer,superbugs,digestivecomplaints,andmore.JohnWiley&SonsCanada,Ltd.2008pg.11

12. Jean-PierreHugot.Inflammatoryboweldisease:acomplexgroupofgeneticdisorders;BestPractice&ResearchClinicalGastroenterology,Volume18,Issue3,Pages451-462,June2004·AVenketRao,AlisonCBested,TraceyMBeaulne,MartinAKatzman,ChristinaIorio5,JohnMBerardi6andAlanCLogan.Arandomized,double-blind,placebo-controlledpilotstudyofaprobioticinemotionalsymptomsofchronicfatiguesyndrome;GutPathogens2009,1:6·Huey-ShiLye,Chiu-YinKuan,Joo-AnnEwe,Wai-YeeFungandMin-TzeLiong.TheImprovementofHypertensionbyProbiotics:EffectsonCholesterol,Diabetes,Renin,andPhytoestrogens;Int.J.Mol.Sci.2009,10,3755-3775.·GregoryJ.Leyer,PhDa,ShuguangLi,MSb,MohamedE.Mubasher,PhDc,CherylReifer,PhDd,ArthurC.Ouwehand,PhDe.ProbioticEffectsonColdandInfluenza-LikeSymptomIncidenceandDurationinChildren;Pediatrics2009;124;e172.·SilviaWilsonGratz,HannuMykkanen,andHaniSEl-Nezami.Probioticsandguthealth:Aspecialfocusonliverdiseases;WorldJGastroenterol.2010January28;16(4):403–410.·WhitneyPBowe,AlanCLogan.Acnevulgaris,probioticsandthegut-brain-skinaxis-backtothefuture?GutPathogens2011,3:1.·ÅsaSullivan,CarlENordandBirgittaEvengård.Effectofsupplementwithlactic-acidproducingbacteriaonfatigueandphysicalactivityinpatientswithchronicfatiguesyndrome;NutritionJournal2009,8:4.·MajamaaH,IsolauriE.Probiotics:anovelapproachinthemanagementoffoodallergy;JAllergyClinImmunol.1997Feb;99(2):179-85.·CaniPD,DelzenneNM.Involvementofthegutmicrobiotainthedevelopmentoflowgradeinflammationassociatedwithobesity:focusonthisneglectedpartner;ActaGastroenterolBelg.2010Apr-Jun;73(2):267-9.·DiBaiseJK,ZhangH,CrowellMD,Krajmalnik-BrownR,DeckerGA,RittmannBE.Gutmicrobiotaanditspossiblerelationshipwithobesity.MayoClinProc.2008Apr;83(4):460-9.·KadookaY,SatoM,ImaizumiK,OgawaA,IkuyamaK,AkaiY,OkanoM,KagoshimaM,TsuchidaT.Regulationofabdominaladipositybyprobiotics(LactobacillusgasseriSBT2055)inadultswithobesetendenciesinarandomizedcontrolledtrial;EurJClinNutr.2010Jun;64(6):636-43.

13. DiBaiseJK,ZhangH,CrowellMD,Krajmalnik-BrownR,DeckerGA,RittmannBE.Gutmicrobiotaanditspossiblerelationshipwithobesity.MayoClinProc.2008Apr;83(4):460-9.

14. KadookaY,SatoM,ImaizumiK,OgawaA,IkuyamaK,AkaiY,OkanoM,KagoshimaM,TsuchidaT.Regulationofabdominaladipositybyprobiotics(LactobacillusgasseriSBT2055)inadultswithobesetendenciesinarandomizedcontrolledtrial;EurJClinNutr.2010Jun;64(6):636-43.

15. LauriHicks,D.O.,LenHorovitz,M.D.,U.S.OutpatientAntibioticPrescribing,2010NewEnglandJournalofMedicine2013;368:1461-1462

16. Payne,A.N.,Chassard,C.andLacroix,C.(2012),Gutmicrobialadaptationtodietaryconsumptionoffructose,artificialsweetenersandsugaralcohols:implicationsforhost–microbeinteractionscontributingtoobesity.ObesityReviews,13:799–809.doi:10.1111/j.1467-789X.2012.01009.x

17. WKruis,GForstmaier,CScheurlen,FStellaard.Effectofdietslowandhighinrefinedsugarsonguttransit,bileacidmetabolism,andbacterialfermentation;Gut,1991,32,367-371

18. CookMT,TzortzisG,CharalampopoulosD,KhutoryanskiyVV.Microencapsulationofprobioticsforgastrointestinaldelivery.JControlRelease.2012Aug20;162(1):56-67.

19. DelPianoM,MorelliL,StrozziGP,AllesinaS,BarbaM,DeiddaF,LorenziniP,BallaréM,MontinoF,OrselloM,SartoriM,GarelloE,CarmagnolaS,PagliaruloM,CapursoL.Probiotics:fromresearchtoconsumer;DigLiverDis.2006Dec;38Suppl2:S248-55.



14

20. KailasapathyK.Microencapsulationofprobioticbacteria:technologyandpotentialapplications.CurrIssuesIntestMicrobiol.2002Sep;3(2):39-48.

21. B.Klarinetal.,“AdhesionoftheProbioticBacteriumLactobacillusplantarum299vontotheGutMucosainCriticallyIllPatients:ARandomizedOpenTrial,”Crit.Care9(3),R285–293(2005).P.Mangelletal.,“Lactobacillusplantarum299vInhibitsEscherichiacoli-InducedIntestinalPermeability,”Dig.Dis.Sci.47(3),511–516(2002).

22 9.D.R.Macketal.,“ProbioticsInhibitEnteropathogenicE.ColiAdherenceinvitrobyInducingIntestinalMucinGeneExpression,”Am.J.Physiol.276,G941–G950(1999).

23. J.Levy,“TheEffectsofAntibioticUseonGastrointestinalFunction,”Am.J.Gastroenterol.95,S8–S10(2000).M.Percival,“ChoosingAProbioticSupplement,”Clin.Nutr.Insights6,1–4(1997).Y.Aibaetal.,“LacticAcid-MediatedSuppressionofHelicobacterpyloribytheOralAdministrationofLactobacillussalivariusasaProbioticinaGnotobioticMurineModel,”Am.J.Gastroenterol.93,2097–2101(1998).P.Gionchettietal.,“OralBacteriotherapyasMaintenanceTreatmentinPatientswithChronicPouchitis:ADouble-Blind,Placebo-ControlledTrial,”Gastroenterol.119,305–309(2000).

24. J.A.Drisko,C.K.GilesandB.J.Bischoff,“ProbioticsinHealthMaintenanceandDiseasePrevention,”Altern.Med.Rev.8(2),143–155(2003).

25. S.MichailandF.Abernathy,“LactobacillusplantarumReducestheinvitroSecretoryResponseofIntestinalEpithelialCellstoEnteropathogenicEscherichiacoliInfection,”J.Pediatr.Gastroenterol.Nutr.35(3),350–355(2002).

26. DalieD.K.D.,DeschampsA.M.,Richard-ForgetF.Lacticacidbacteria-Potentialforcontrolofmouldgrowthandmycotoxins:Areview(2010)FoodControl,21(4),pp.370-380.

27. Niku-Paavola,M.L,Laitila,A,Mattila-Sandholm,T.,&Haikara,A(1999).NewTypesofanitmicrobialcompoundsproducedbyLactobacillusplantarum.JournalofAppliedMicrobiology,86,29-35.

28. Lavermicocca,P.,Valerio,F.,&Visconti,A.(2003).Antifungalactivityofphenyllacticacidagianstmoldsisolatedfrombakeryproducts.AppliedandEnvironmentalMicrobiology,69,634-640

29. Strom,K.,Schnurer,J.,&Melin,P.(2005)Co-cultivationofantifungalLactobacillusplantarumMiLAB393andAspergillusnidulans,evaluationofeffectsonfungalgrothandproteinexpression.FEMSMicrobiologyLetters,246119-124.Strom,K.Sjogren,J.,Broberg,A&Schnurer,J.(2002).LactobacillusplantarumMiLAB393producestheantifungalcyclicdipeptidescyclo(L-Phe-Pro)andcyclo(L-Phe-trans-4-OH-L-Pro)andphenyllacticacid.AppliedandEnvironmentalMicrobiology,68,4322-4327

30. Piotrowska,M.,&Zakowska,Z.(2005).ThelimitationofochratoxinAbylacticacidbacteriastrains.PolishJournalofMicrobiology,54,279–286.

31. Pfohl-LeszkowiczA,MandervilleRA(2007).“OchratoxinA:Anoverviewontoxicityandcarcinogenicityinanimalsandhumans”.MolNutrFoodRes51(1):61–99.

32. BlesaJ,etal.(2006).“FactorsaffectingthepresenceofochratoxinAinwines”.Criticalreviewsinfoodscienceandnutrition46(6):473–8

33. O’BrienE,DietrichDR(2005).“OchratoxinA:thecontinuingenigma”.Crit.Rev.Toxicol.

34. (1):33–60.34PalmaN,etal.(2007).“OchratoxinA-InducedMutagenesisinMammalianCellsIsConsistentwiththeProductionofOxidativeStress”.ChemicalResearchinToxicology20(7):1031–1037

35. BelmadaniA.,etal(1999).“SelectivetoxicityofochratoxinAinprimaryculturesfromdifferentbrainregions”.ArchToxicol73(2):108–114.

36. SavaV.,etal.(2006.).“AcuteneurotoxiceffectsofthefungalmetaboliteochratoxinA”.Neurotoxicology27(1):82–92.


38. Haskard,C.,El-Nezami,G.S.,Kankaanpaa,P.E.,Salminen,S.,&Ahokas,J.T.(1998)SequestrationofAflatoxinB1byprobioticstrains:Bindingcapacityandlocalization.RevuedeMedecineVeterinaire,149,571

39. AdvancingMedicinewithFoodandNutrients2ndEd.Pg839-40

40. El-Nezami,H.S.,Chrevatidis,A.,Auriola,S.,Salminen,S.,&Mykkänen,H.(2002c).RemovalofcommonFusariumtoxinsinvitrobystrainsofLactobacillusandPropionibacterium.FoodAdditivesandContaminants,19,680–686.

41. InternationalJournalofMolecularScience,2009.10(1):p.1-17

42. AdvancingMedicinewithFoodandNutrients2ndEd.Pg830

43. MedicalMycology2010.56:p.282-294,ToxicologyandAppliedPharmacology,2008.228(1):p.84-92

44. AdvancingMedicinewithFoodandNutrients2ndEd.Pg834



15

45. El-Nezami,H.S.,Polychronaki,N.,Salminen,S.,&Mykkänen,H.(2002a).Bindingrathermetabolismmayexplaintheinteractionoftwofood-gradeLactobacillusstrainswithzearalenoneanditsderivativea-zearalenol.AppliedandEnvironmentalMicrobiology,68,3545–3549.


47. Kuiper-Goodman,T.;Scott,P.M.;Watanabe,H.(1987).“RiskAssessmentoftheMycotoxinZearalenone”.RegulatoryToxicologyandPharmacology7(3):253–306.

48. AllenSJ,OkokoB,MartinezE,GregorioG,DansLF.Probioticsfortreatinginfectiousdiarrhoea.CochraneDatabaseSystRev2004;(2):CD003048.

49. TongJL,RanZH,ShenJ,ZhangCX,XiaoSD.Meta-analysis:theeffectofsupplementationwithprobioticsoneradicationratesandadverseeventsduringHelicobacterpylorieradicationtherapy.AlimentPharmacolTher2007;25:155–68.

50. GawronskaA,DziechciarzP,HorvathA,SzajewskaH.Arandomizeddouble-blindplacebo-controlledtrialofLactobacillusGGforabdominalpaindisordersinchildren.AlimentPharmacolTher2007;25:177–84.

51. YoshinoriHAMAJI,MinoruFUJIMORI,TakayukiSASAKI,HitomiMATSUHASHI,KeiichiMATSUI-SEKI,YukoSHIMATANI-SHIBATA,YasunobuKANO,JunAMANOandShun’ichiroTANIGUCHI,“StrongEnhancementofRecombinantCytosineDeaminaseActivityinBifidobacteriumlongumforTumor-TargetingEnzyme/ProdrugTherapy”,Biosci.Biotechnol.Biochem.,Vol.71,874-883(2007).

52. Xiao,JZetal.“ClinicalEfficacyofProbioticBifidobacteriumlongumfortheTreatmentofSymptomsofJapaneseCedarPollenAllergyinSubjectsEvaluatedinanEnvironmentalExposureUnit”.AllergologyInternational.PublishedMarch2007.

53. OhnoHiroshi,TsunemineSatoru,IsaYasuhiro,ShimakawaMasaki,YamamuruHideki.OralAdministrationBifidobacteriumbifidumG9-1SuppressesTotalandAntigenSpecificImmunoglobulinEProductioninMice.BiologicalandPharmaceuticalBulletin28(8)pp.1462-146620050801

54. Amenta,Micheleetal.“Dietandchronicconstipation.Benefitsoforalsupplementationwithsymbioticzirfos(BifidobacteriumlongumW11+FOSActilight)”.ActaBiomed.PublishedDecember2006.


56. O’MahonyL,McCarthyJ,KellyP,etal.LactobacillusandBifidobacteriuminirritablebowelsyndrome:symptomresponsesandrelationshiptocytokineprofiles.Gastroenterology2005;128:541–51.

57. GibsonGR,WangX.Regulatoryeffectsofbifidobacteriaonthegrowthofothercolonicbacteria.JApplBacteriol.1994Oct;77(4):412-20.

58. SánchezB,Champomier-VergèsMC,ColladoMdelC,AngladeP,BaraigeF,SanzY,delosReyes-GavilánCG,MargollesA,ZagorecM.Low-pHadaptationandtheacidtoleranceresponseofBifidobacteriumlongumbiotypelongum.ApplEnvironMicrobiol.2007Oct;73(20):6450-9.

59. HeF,OuwehanAC,HashimotoH,IsolauriE,BennoY,SalminenS.AdhesionofBifidobacteriumspp.tohumanintestinalmucus.MicrobiolImmunol.2001;45(3):259-62.

60. BiasucciG,RubiniM,RiboniS,MorelliL,BessiE,RetetangosC.Modeofdeliveryaffectsthebacterialcommunityinthenewborngut.EarlyHumDev.2010Jul;86Suppl1:13-5.

61. IshibashiN,YamazakiS.Probioticsandsafety.AmJClinNutr.2001Feb;73(2Suppl):465S-470S.

62. TakiK,TakayamaF,NiwaT.BeneficialeffectsofBifidobacteriainagastroresistantseamlesscapsuleonhyperhomocysteinemiainhemodialysispatients.JRenNutr.2005Jan;15(1):77-80.

63. KorshunovVM,GudievaZA,EfimovBA,PikinaAP,SmeianovVV,ReidG,KorshunovaOV,TiutiunnikVL,StepinII.[ThevaginalBifidobacteriumflorainwomenofreproductiveage].ZhMikrobiolEpidemiolImmunobiol.1999Jul-Aug;(4):74-8.


65. Marteau,P.R.,Vrese,M.,Cellier,C.J.andSchrezenmeir,J.(2001).Protectionfromgastrointestinaldiseaseswiththeuseofprobiotics.AmJClinNutr,73:430-436.


67. “LactobacillusAcidophilus.”UniversityofMarylandMedicalCenter.http://www.umm.edu/altmed/articles/lactobacillus-acidophilus-000310.htm.



16

68. FitzsimmonsN,BerryDR.InhibitionofCandidaalbicansbyLactobacillusacidophilus:evidencefortheinvolvementofaperoxidasesystem.Microbios1994;80:125–33.

69. HiltonE,IsenbergHD,AlpersteinP,etal.IngestionofyogurtcontainingLactobacillusacidophilusasprophylaxisforcandidalvaginitis.AnnInternMed1992;116:353–7.

70. Millette,M.etal.2010.ProbioticLactobacillusacidophilusandL.caseimixsensitizecolorectaltumoralcellsto5-fluorouracil-inducedapoptosis.NutritionandCancer.62(3):371-8.


72. KoebnickC,WagnerI,LeitzmannP,SternU,ZunftHJF.ProbioticbeveragecontainingLactobacilluscaseiShirotaimprovesgastrointestinalsymptomsinpatientswithchronicconstipation.CanJGastroenterol2003;17:655-9.

73. LactobacillusCasei,publishedbyCitizendium,TheCitizens’Compendium,2009.

74. Millette,M.etal.2010.ProbioticLactobacillusacidophilusandL.caseimixsensitizecolorectaltumoralcellsto5-fluorouracil-inducedapoptosis.NutritionandCancer.62(3):371-8.

75. PlummerS,WeaverMA,HarrisJC,etal.Clostridiumdifficilepilotstudy:effectsofprobioticsupplementationontheincidenceofClostridiumdifficilediarrhoea.IntMicrobiol2004;7:59–62.

76. SýkoraJ,ValeckováK,AmlerováJ,etal.EffectsofaspeciallydesignedfermentedmilkproductcontainingprobioticLactobacilluscaseiDN-114001andtheeradicationofH.pyloriinchildren:aprospectiverandomizeddouble-blindstudy.JClinGastroenterol2005;39:692–8.

77. ProbioticStrains.PublishedonInnovativeIngredientsforInnovativeFoods,Lal’Food-InstituteRosell.2009.

78. LactobacillusHelveticus.PublishedbyWellnessAdvocate,WellnessAdvocate&WellnessAdvantage.2007.

79. avernitiVandGuglielmettiS(2012)Health-promotingpropertiesofLactobacillushelveticus.Front.Microbio.3:392.doi:10.3389/fmicb.2012.00392

80. avernitiVandGuglielmettiS(2012)Health-promotingpropertiesofLactobacillushelveticus.Front.Microbio.3:392.doi:10.3389/fmicb.2012.00392

81. MayanagiG,KimuraM,NakayaS,HirataH,SakamotoM,BennoY,ShimauchiH.ProbioticeffectsoforallyadministeredLactobacillussalivariusWB21-containingtabletsonperiodontopathicbacteria:adouble-blinded,placebo-controlled,randomizedclinicaltrial;JClinPeriodontol.2009Jun;36(6):506-13.Epub2009Apr22.IwamotoT,SuzukiN,TanabeK,TakeshitaT,HirofujiT.EffectsofprobioticLactobacillussalivariusWB21onhalitosisandoralhealth:anopen-labelpilottrial;OralSurgOralMedOralPatholOralRadiolEndod.2010Aug;110(2):201-8.

82. RyanKA,DalyP,LiY,HootonC,O’ToolePW.Strain-specificinhibitionofHelicobacterpyloribyLactobacillussalivariusandotherlactobacilli.JAntimicrobChemother.2008Apr;61(4):831-4.


84. Mandal,V.,Sen,S.K,&MandalN.C.(2007)Detection,isolationandpartialcharacterizationofantifungalcompound9s0producedbyPediococcusacidilacticiLAB5.NaturalProductCommunications,2,671-674

85. LeeSH,LillehojHS,ParkDW,HongYH,andLinJJ.2007.EffectsofPediococcus–andSaccharomyces-basedprobiotic(MitoMax)oncoccidiosisinbroilerchickens.ComparativeImmunoMicrobiol&Infectiousdisease.30:261-268

86. DalloulR.A.,LillehojH.S,LeeJ.S.,LeeS.H.,ChungK.S.2006.ImmunopotentiatingeffectofaFomitellafraxinea–derivedlectinonchickenimmunityandresistancetococcidiosis.Poult.Sci.85: 446S-451S

87. TakataK,KinoshitaM,OkunoT,MoriyaM,KohdaT,etal.(2011)TheLacticAcidBacteriumPediococcusacidilacticiSuppressesAutoimmuneEncephalomyelitisbyInducingIL-10-ProducingRegulatoryTCells.PLoSONE6(11):e27644.

88. CurrentTrendsinBiotechnologyandPharmacyVol.6(1)1-14January2012,ISSN0973-8916(Print),2230-7303

89. SaavedraJM,Abi-HannaA,MooreN,YolkenRH.Long-termconsumptionofinfantformulascontainingliveprobioticbacteria:toleranceandsafety.AmJClinNutr2004;79:261–7.

90. HaticeBoke,BelmaAslim,andGulcinAlp,TheRoleofResistancetobilesaltsandacidtoleranceofExopolysaccharideis(EPSS)producedbyyogurtstarterbacteria.Arch.Biol.Sci.,Belgrade,62(2),323-328,2010

91. Drouault,S;Anba,J;Corthier,G,Streptococcusthermophilusisabletoproduceabeta-galactosidaseactiveduringitstransitinthedigestivetractofgerm-freemice.APPLIEDANDENVIRONMENTALMICROBIOLOGYVolume:68Issue:2Pages:938-941

92. SheilB,ShanahanF,O’MahonyL.Probioticeffectsoninflammatoryboweldisease.JNutr.2007Mar;137(3Suppl2):819S-24S.

1



humarian patient ebook 2-17-15

Documents

gastrointestinal system

gastrointestinal gi

digestion of food

digestion center

healthy gut

theenteric nervous system

gastrointestinal gi

chronic health problems