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    Same things about your

    dissertation

    andsomething more!

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    Outline

    General Aspects

    Organizing your dissertation

    Writing style

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    Homeopathy is witchcraft:

    Brit docs*

    BMA said taxpayers

    should not foot the bill

    for remedies with no

    scientific basis to

    support them.

    * Times of India, May 16, 2010

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    Challenges in Siddha research System related

    Lack of generalizability

    No uniformity (in diagnosis, drug standards,treatment)

    Safety issues

    Person related Lack of interest / mentality

    Technical knowledge

    Lack of personnel Lack of collaboration

    Funding

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    An overview of dissertation

    Disserto (latin) discuss

    A research report

    History

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    Purpose of dissertation

    Promote the development of criticaljudgment, habits of self education,imagination and scholarship as well as the

    acquisition of knowledge and researchskills

    Produce physicians who can evaluate datacritically

    Learn how to understand scientificmethods practically

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    The beginning

    When to start

    Have 3 or 4 topics

    Prepare a concept paper

    Pilot study

    If change needed

    Can finish well in advance

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    Choosing a research topic

    FINER*

    Feasible

    Interesting

    Novel

    Ethical

    Relevant

    No controversies

    *Hulley et al, 2001

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    Planning your dissertation

    Develop a protocol; get itapproved by technicalcommittee (may be theguide) and ethics committeeand stick to it

    Make a time-table (using

    software, GANTT chart)

    List of things to get doneinside college and outside

    List the people to discusswith, places/labs to contact

    Make a folder for eachchapter

    Keep your time and budgetlimits in mind

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    Task Name Duration

    Aug-06

    Sep-06

    Oct-06

    Nov-06

    Dec-06

    Jan-07

    Feb-07

    Mar-07

    Apr-07

    May-07

    June-07

    July-07

    Aug-07

    Sep-07

    Oct-07

    Nov-07

    Dec-07

    Jan-08

    Feb-08

    Mar-08

    Apr-08

    May-08

    June-08

    July-08

    1. Planning &

    Preparation 12 weeks

    2. Workshop to

    develop the tool

    (NDST) and CCC 4 weeks

    3. Pilot the tool4 weeks

    4. Finalize the tool4 weeks

    5. Validation of NDST

    5.1Training workshop

    (National & Zonal)4 weeks

    5.2Data Collection8 weeks

    5.3Data analysis4 weeks

    5.4 Report writing4 weeks

    5.5Dissemination4 weeks

    6.Prevalence survey

    6.1Training workshop

    (National & Zonal)

    4 weeks

    6.2 Data Collection24 weeks

    6.3 Data analysis8 weeks

    6.4 Report writing8 weeks

    6.5 Dissemination4 weeks

    Total Duration24 months

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    The layout (Structure)

    The Beginning: Title Page Dedication Acknowledgements Table of Contents List of Figures / Tables / Appendices / Abbreviations (also known as

    Nomenclature in some disciplines) IMRaD structure Introduction Methods Results (And) Discussion References (also known as Bibliography in some disciplines) Glossary Appendices

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    Proportion of contents

    Introduction (incl. RoL) - 20 30%

    Methods - 10 20%

    Results - 30 40% Discussion - 20 25%

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    Title

    Clear

    Specific but comprehensive

    Short / crispy but sufficiently descriptive Interesting and attractive

    No abbreviations

    Should be easy to catalogue

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    Introduction

    Background material to make the readerunderstand

    Existing state of knowledge

    Gaps in knowledge which research will fill

    State what you Intend to do How the topic was chosen

    How it is related to the contemporary world

    It does not Review the history of the subject

    Does not identify all the other gaps in knowledge

    Do not include methods, results and discussion

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    Objectives

    What is to be achieved by the study

    General objective

    Specific objective State whether you will be

    Estimating a quantity

    Testing a hypothesis

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    Examples of objectives

    to estimate a quantity

    Measure the level of decline of blood pressureamong patients treated with venthamaraichooranam (Gunapadam, Maruthuvam)

    Estimate the correlation between envagaithervu and allopathic diagnostic methods formega noi patients (Noi nadal)

    Descriptive analysis of similarities between

    xxxx varma points in Siddha system with xxxxacupuncture points in traditional Chinesemedicine (Sirappu maruthuvam)

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    Examples of objectives

    to test a hypothesis

    Determine the effectiveness of venthamarai

    chooranam versus asai chooranam in reducing blood

    pressure among newly diagnosed patients with

    pithathikkam

    Determine the diagnostic validity of neer kuri and nei

    kuri compared with Hb1Ac among newly diagnosed

    patients with Diabetes mellitus

    Determine the efficacy of Aya pringaraja panitham as

    compared to banana panitham in the treatment ofanaemia among children

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    Review of literature

    Relevant material of past

    Global National Local

    Progressively zoom in

    Dont just copy/paste

    Sources Previous dissertations

    Journals

    Websites Books

    References

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    Methods

    Explain what you did in simple terms

    Provide key information Variables

    Type of study

    Data collection techniques

    Sampling

    Sample size

    Plan for data collection

    Plan for data processing and analysis

    Ethical considerations

    Pretest / Pilot study

    Do not add results

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    Statistical analysis

    Clinical trial Descriptive statistics

    For before and after treatment assessments Paired t test for means

    McNemars Chi-square for proportions

    For two groups t test for means Chi-square for proportions

    Multivariate analysis to study the independent effect of the trial drug

    Toxicology study Descriptive statistics

    Diagnostic study Descriptive statistics Sensitivity, specificity, predictive values, likelihood ratios, ROC curves

    (if applicable)

    McNemars Chi-square

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    Results

    Describe your findings in simple terms

    Do not use general sentences

    Start with baseline characteristics

    Do not explain methods (e.g., criteria used)

    Always give numbers, and not only proportions Of the XX subjects, XX (XX%) reported doing

    Describe the information in the tables as captions Cases and controls did not differ with respect to baseline

    characteristics (Table 1). Back up statements with data in the sentence, data in

    the tables or mention data not shown

    Do not discuss results nor use references

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    Discussion

    Discuss by

    Objectives

    Variables

    Basis for conclusion and recommendation

    Other studies

    Support or contradict

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    Summary & Conclusion

    Summarize all in short paragraphs (one

    page)

    Draw conclusion from your summary

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    Recommendations

    Dont confuse conclusions &

    recommendations

    Based on your observations

    For the betterment of

    To whom administrative people, policy

    makers, fellow researchers and

    practitioners, community at large

    Suggestions for future works

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    Limitations

    Imposed mainly by Budget

    Time constraints

    Possible limitations Sample size

    Investigations

    State them directly

    State to which extend the study would

    have been degraded

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    Appendix

    Case Report Form

    Questionnaire Proforma

    Consent form

    Others

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    Reference citation

    Follow guidelines of the ICMJE (www.icmje.org)

    For an article:Author(s) Surname followed byinitials - Title of article - Name of Journal -

    Year, Volume, (number): page numbers ofarticle.

    For a book:Author(s) Surname followed byinitials. Title of book. Place: Publisher, year,

    Edition

    For a website: Author Title of the webpage Name of the website Date of publication URL

    http://www.icmje.org/http://www.icmje.org/
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    Problems you may face during your

    dissertation study

    Poor number of cases

    Laboratory results not so encouraging

    Mid-time changes Controversies with guide / authorities

    Unexpected health conditions

    Psychological lack of enthusiasm aftersome time

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    Regulations of TNMMU (1/2)

    Students will be assigned a topic within 4months of his admission and be intimated tothe COE.

    HOD will assign a topic In lieu of Dissertation, Proof of publication

    or acceptance as a principal author in areputed medical journal Bound Volume. Minimum 50 pages and

    maximum 75 pages. Typed matter. Double-spacing. One side only excluding certificate,

    acknowledgement, annexure & bibliography 4 copies to be submitted 4 months prior tothe exam to the COE

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    Regulations of TNMMU (2/2)

    Evaluated by 4 examiners at the time ofClinical/Practical exam

    Dissertation is approved but examiners suggestminor corrections & resubmission. Thecandidates' results shall be withheld, again

    reexamined. If failed in the written/practical, Dissertation

    mark will be carried over to the subsequentexams

    If Dissertation is rejected by two exams or more,

    Candidate is permitted to appear forwritten/practical exams but results will not bedeclared/withheld. Resubmit prior to the nextexam.

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    Regulations of CCIM

    General expectations Must contain own account of research

    Able to re-express observations and draw conclusions

    Be suitable for its publication in an abridged form

    Contents

    Contain a summary < 150 words Outer cover: title, the names of dissertation, department, student,

    guide and year of submission

    50-150 pages including chart, diagram, photograph. Bibliography etc.

    Number of copies One each for the libraries of University, College and the guide

    Publication requirements Shall become the property of the University and seek permission to

    publish from the university

    In no case, it should be published before it is accepted

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    Regulations of CCIM : Time-line

    Title be registered with the University within onemonth from the declaration of the result of the secondyear examination

    Submission by 1 October of the year preceding the year

    of final examination Should be submitted during the third year of the

    examination

    If not approved Returned to the student with the remarks of the examiner

    Resubmit the same after complying with the observations ofthe examiners

    Two chances for resubmission of the dissertation at the end ofsix months period each after the first submission

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    Points to consider (1/4)

    Be brief & to the point

    Avoid repetition and duplication of ideas

    Spare and allow enough time for writing

    Use a simple direct style which is condensed but not so

    condensed as to be critic or sacrifices precision andclarity of results

    Organize the material in a logical sequence and notaccording to the order in which experiments were

    conducted Revise the material until it has unity, coherence,

    emphasis and accuracy and so clear that it cannot bemisunderstood

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    Points to consider (2/4)

    Avoid unnecessary details. However give all the factsnecessary for a trained person to repeat the

    experiment(s)

    Design suitable headings, sub-headings and sub-sub-

    headings. The paragraphs and sentences should beshort, to enable the reader to skim the thesis for its

    general subject matter and to locate quickly any

    detailed part he/she seeks or interested

    Let the tabular data and illustrations speak for

    themselves. Confine the text discussion for meaning of

    data.

    Plan the illustrations and tables according to the page

    dimensions

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    Points to consider (3/4)

    Insert the photos that are glossy, have plenty of

    contrast and pertain to the text.

    Avoid long and complex or undigested (unclassified)

    data or too many tables

    Arrange the tables that to portrait or landscape on a

    page wherever possible and so cast these that they

    could be accommodated in the prescribed format

    Provide a complete caption/title for every table,figure and illustration which is self explanatory and

    nouns in the caption /title should preferably start in

    capital

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    Points to consider (4/4)

    Provide clear and concise column headings and

    subheadings

    Explain every symbol used in a table as a footnote of

    the same

    Avoid footnotes for the citation of references, if any,

    should be included in the text and quoted in the list of

    references at the end of the thesis proceeding to

    appendices

    Include letter, survey forms, raw data, statisticalcomputations and other materials which have been

    used or collected during the study in the appendices

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    Scientific writing style

    Use the past to report what you did

    Use the present for established facts

    Write short, sequential sentences

    Place one idea per sentence

    Be specific

    Do not use bold nor underlining

    Do not include footnotes

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    Things to avoid inscientific writing

    Avoid qualifiers This was a verylarge outbreak

    Avoid emphasis This is the largest outbreak ever reported as thousands and

    thousands of people were affected

    Avoid accusations Irresponsible behaviours among health care workers lead to

    the spread of this Lassa fever outbreak

    Avoid apologies Because of a lack of resources we could not

    Avoid clearly If it is clear, you dont need the word clearly

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    Examples of passive and active voice

    use

    Passive voice A study was conducted

    A sample was selected

    Questionnaires were administered Active voice

    We conducted a study

    We selected a sample Field workers administered the

    questionnaires

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    Documenting the evidence

    Verbs to use

    Clear evidence: Use Indicate

    Partial evidence: Use Suggest

    Words to avoid Probably use may

    Show use indicate

    Prove use indicate

    Reveal use indicate or suggest

    It appears Spell out what data suggests that

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    Optimizing the center

    of gravity of the sentence

    Each sentence contains a main idea

    The verb constitutes the centre of gravity

    of a sentence

    Make sure the verb contains the key idea

    Avoid neutral verbs

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    Optimizing the centre of gravity of

    the sentence: Examples

    We conducted an investigation of theoutbreak

    We investigated the outbreak

    We tooka sample of the population

    We sampledthe population

    We madean assessment of the situation

    We assessedthe situation

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    Measuring and testing

    The verb estimate denotes measurement

    The verb determine denotes hypothesis testing

    Assess is generic and must be replaced when dealingwith measurement or hypothesis testing

    (OK for the general idea of assessment) Examples

    We determined the prevalence of trachoma

    We estimated the prevalence of trachoma

    The objective was to assess the use of short course treatment

    The objective was to determine whether short coursetreatment can be used

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    Proof reading (1/2)

    Names, initials and affiliations

    Formatting errors

    Typos

    Symbols

    Reference numbering

    Reference format

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    Proof reading (2/2)

    Tables

    Alignment

    Totals

    Calculations

    Digit loss

    Figures

    Re-drawn OK

    No format loss

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    Resources

    http://www.who.int

    http://www.whoindia.org

    http://www.icmr.nic.in

    http://www.ijaronline.nic.in

    http://www.cdc.gov

    http://www.idrc.ca/openebooks/069-1/

    http://www.annals.org

    http://www.biomedcentral.com

    http://www.who.int/http://www.whoindia.org/http://www.icmr.nic.in/http://www.ijaronline.nic.in/http://www.cdc.gov/http://www.idrc.ca/openebooks/069-1/http://www.annals.org/http://www.biomedcentral.com/http://www.biomedcentral.com/http://www.annals.org/http://www.idrc.ca/openebooks/069-1/http://www.idrc.ca/openebooks/069-1/http://www.idrc.ca/openebooks/069-1/http://www.cdc.gov/http://www.ijaronline.nic.in/http://www.icmr.nic.in/http://www.whoindia.org/http://www.who.int/
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    Examiners point of view

    Review of literature

    To what extent is the review relevant to the research

    study?

    Has the candidate slipped into Here is all I know about

    x?

    Is there evidence of critical appraisal of other work, or is

    the review just descriptive?

    How well has the candidate mastered the technical or

    theoretical literature?

    Does the candidate make the links between the reviewand his or her methodology explicit?

    Is there a summary of the essential features of other work

    as it relates to this study?

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    Examiners point of viewMethodology

    What precautions were taken against likely sourcesof bias?

    What are the limitations in the methodology? Is the

    candidate aware of them?

    Is the methodology for data collection appropriate?

    Are the techniques used for analysis appropriate?

    In the circumstances, has the best methodology been

    chosen? Has the candidate given an adequate justification to

    the methodology?

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    Examiners point of viewResults

    Have the hypotheses in fact been tested?

    Do the solutions obtained relate to the questions

    posed?

    Is the level and form of analysis appropriate for thedata?

    Could the presentation of the results been made

    clearer?

    Are patterns and trends in the results accuratelyidentified and summarized?

    Does the software appear to work satisfactorily?

    f

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    Examiners point of viewDiscussion & Conclusion

    Is the candidate aware of possible limits to

    confidence/reliability/validity of the work?

    Have the main points to emerge from the results

    been picked up for discussion? Are there links made to the literature?

    Is there evidence of attempts at theory building or

    reconceptualisation of problems?

    Are there speculations? Are they well grounded inthe results?

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    Defense

    Lets see, what can I ask the candidate? The examiners may have decided before the exam

    whether to pass you.

    Abstract References Summary & Conclusion

    Defense, viva, exam, ... viva = viva voce = lively discussion

    The exam is to check its your work... Talk fluently about the work; show youve thought

    about it (which you have!).

    ...and a chance to clarify things that arent clear inthe thesis. These are areas where corrections are likely.

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    After passing

    Go far more detailed, next level studies

    Practice it!

    Publish

    Disseminate Effort of DoS, TNMMU

    D fi iti f l l f id d di

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    Definition of levels of evidence and gradingof recommendation

    Level Type of evidence available from Grade

    I a Meta-analysis of RCTsA

    I b At least one RCT

    I I a At least one well-designed controlled studywithout randomization

    BI I b At least one other type of well-designed quasi-

    experimental study

    III Well-designed non-experimental descriptivestudies

    IV Expert committee reports or opinions and/or

    clinical experience of respected authoritiesC

    Ph f i l

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    Phase I Clinical pharmacology & toxicity Human volunteers

    Hospital study

    Phase II Initial clinical investigation for treatment effects

    Patients Hospital study

    Phase III Full-scale evaluation

    Patients

    Hospital study

    Phase IV Post-marketing surveillance

    Phases of trial

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    Possible study designs in Siddha

    Observational What is the biochemical profile of patients taking

    siddha medicine for more than six months

    Exploratory Literature Siddha Vaithiya Thirattu

    Clinical trial Open, non-randomized, RCT, Meta-analysis

    Case control To establish the cause as per Siddha system

    Cohort Same as above

    Toxicity Diagnostic

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    [email protected] 01 9902