homeostasis kolesterol
DESCRIPTION
Homeostasis KolesterolTRANSCRIPT
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Journal readingCholesterol versus other sterols: How do they compare as
physiological regulators of cholesterol homeostasis?
Kelompok A-16
Blok biomedik 2
FAKULTAS KEDOKTERAN
UNIVERSITAS YARSIJAKARTA2012/2013
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Kelompok A-16
Ketua : Devi Nurfadila Fani 1102012058
Sekretaris : Juwita 1102012138
Anggota :
Abd. Halim Ghazali H 110201201
Azando Rizki Putra 110201203
Citra Nurul 1102011067
Deny Susanto 1102012054
Fauziana Ulfa 1102012084
Gilang Anugrah 1102012097
Gus Dinda Marsella 1102012102
Halima Tusadia Tahari 1102012103
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Homeostasis kolesterol
Kolesterol itu terdapat pada plasma darah dan jaringan.
Homeostasis kolesterol adalah keseimbangan antara sintesis
kolesterol dengan penyerapannya dan penghambatannya.
Keseimbangan kolesterol pada umumnya dipertahankan antara
faktor-faktor yang menyebabkan diperolehnya kolesterol dan
faktor-faktor yang menyebabkan hilangnya kolesterol.
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Biosintesis kolesterol
tiolase HMG-CoA sintase HMG-CoA sintase
Acetyl CoA Asetoacetyl CoA HMG-CoA
ATP direduksi NADPH
dimetyally difosfat isopentenyl difosfat mevalonate
CO2
geranyl di fosfat farnesyl difosfat squalence squalence epoksidase
squalence epoksida
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Lanjutan biosintesis kolesterol .......
NADPH dan O2 lanosterol siklase
14-dimetyl lanosterol lanosterol squalence epoksida
H-COOH
isomerase NADPH dan O2
Zimosterol kolestadierol demosterol 24- dehidrokolesterol
H-COOH
NADPH 24-reduktase
cholesterol
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24S,25-Epoxycholesterol24S,25-Epoxycholesterol memiliki asal yang unik
onlinelibrary.wiley.com/doi/10.1002/ejlt.201100295/pdf
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24S,25-Epoxycholesterol
http://lipidlibrary.aocs.org/lipids/chol_der/Figure7.png
24S,25-Epoxycholesterol paling berlimpah di otak
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24S,25-Epoxycholesterol
24S,25-Epoxycholesterol juga menjadi sasaran terapi yang menarik khususnya sebagai tambahan untuk meningkatkan efektifitas dan keamanan obat-obatan yang biasanya digunakan untuk menurunkan tingkat kolesterol dalam darah.
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DAFTAR PUSTAKA
Brown Andrew J. 2012. Review Article : Cholesterol versus other sterols: How do they compare as physiological regulators of cholesterol homeostasis?. BABS, School of Biotechnology and Biomolecular Sciences, The University of New South Wales,Sydney, Australia
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