Allele Frequency (%)2DL4 1002DL4*00101 02DL4*00102 602DL4*00201 202DL4*00202 42.52DL4*003 02DL4*004 02DL4*005 352DL4*006 102DL4*007 0

Cytokine Frequency (%)IL-2/-330 GG 26.2IL-2/-330 GT 33.8IL-2/-330 TT 40IL-6/-174 CC 1.3IL-6/-174 CG 22.5IL-6/-174 GG 76.2IL-10/-1082 AA 44.3IL-10/-1082 AG 41.8IL-10/-1082 GG 13.9IL-10/-592 AA 6.3IL-10/-592 AC 36.7IL-10/-592 CC 57IL-10/-819 CC 57IL-10/-819 CT 36.7IL-10/-819 TT 6.3TNFalpha/-308 AA 0TNFalpha/-308 AG 16.2TNFalpha/-308 GG 83.8TNFbeta/252 AA 37.5TNFbeta/252 AG 45TNFbeta/252 GG 17.5

HLA-A, -B, -Cw, -DQB1 and

-DRB1 Allele Frequencies in a

Brahui Population from Pakistan

A. Mohyuddin*, S. Khaliq, Q. Ayuband S.Q. Mehdi

Biomedical and Genetic Engineering Laboratories,Islamabad, PakistanE-mail: *aishamoh@isb.comsats.net.pk

This population from the Balochistan province of Pakistan,Latitude 30–31N Longitude 66–67E consisted of 104 Cau-casian individuals. The individuals were drawn from a ruralenvironment where the grandparents had also lived and HLAalleles were determined using sequence specific primers. TheBrahuis are hypothesized to be of Turko-Iranian (West Asian)

origin. They are the only population in Pakistan that speak aDravidian language and are separated by almost a thousandmiles from other Dravidian speakers in south India and SriLanka. Analysis of their HLA alleles, Y-chromosomes andautosomal microsatellites show no distinction among theBrahuis who speak a Dravidian language and their Indo-European neighbours in Pakistan. The results have previouslybeen published in Tissue Antigens 61, 286–291, 2003 and59, 492–501, 2002. The following alleles could not be dis-tinguished A*0301/03N (frequency entered under A*0301)A*2402/09N/11N (entered under A*2402) Cw*0302/04 (en-tered under Cw*0302) Cw*0801/03 (entered under Cw*0801)DQB1*0301/04 (entered under DQB1*0301). Human Im-munology 65, 1038–1040 (2004). © American Society forHistocompatibility and Immunogenetics, 2004. Published byElsevier Inc.

HLA allele Gene frequencyA*01 0.063A*0101 0.063A*0102 0A*02 0.19A*0201 0.115A*0202 0.023A*0203 0A*0204 0A*0205 0.006A*0206 0.023A*0207 0A*0208 0A*0209 0A*0210 0A*0211 0.023A*0212 0A*0213 0A*0214 0A*0215N 0A*0216 0A*0217 0A*0218 0A*0219 0A*0220 0A*0221 0A*0222 0A*0224 0A*0225 0A*0226 0A*0236 0A*03 0.046A*0301 0.046A*11 0.252A*1101 0.252A*1102 0A*1103 0A*1104 0A*23 0A*2301 0A*24 0.046A*2402 0.04A*24020102L 0.006

1038

Human Immunology 65 (2004)0198-8859/04/$–see front matter© American Society for Histocompatibility and Immunogenetics, 2004

Published by Elsevier Inc.

HLA allele Gene frequencyA*2403 0A*2404 0A*2405 0A*2406 0A*2407 0A*2408 0A*2410 0A*2413 0A*2414 0A*25 0A*2501 0A*2502 0A*26 0.086A*2601 0.08A*2602 0.006A*2604 0A*2605 0A*2606 0A*2607 0A*2608 0A*2609 0A*29 0.017A*2901 0.017A*2902 0A*2903 0A*30 0.045A*3001 0.011A*3002 0.034A*3003 0A*3004 0A*31 0.046A*310102 0.046A*32 0.092A*3201 0.092A*3202 0A*33 0.08A*3301 0A*3303 0.08A*34 0A*3401 0A*3402 0A*36 0A*3601 0A*43 0A*4301 0A*66 0.006A*6601 0.006A*6602 0A*6603 0A*68 0.029A*680101 0.023A*680102 0.006A*6802 0A*6803 0A*6804 0A*6805 0A*69 0

HLA allele Gene frequencyA*6901 0A*80 0A*8001 0B*07 0.038B*0703 0B*08 0.106B*13 0.005B*14 0.014B*1401 0.014B*1402 0B*15 0.024B*18 0.024B*27 0.019B*35 0.159B*37 0.005B*38 0.024B*39 0.019B*40 0.154B*41 0.019B*42 0.014B*44 0.019B*45 0B*46 0.005B*47 0B*48 0B*4801 0B*4802 0B*49 0.005B*50 0.019B*51 0.115B*52 0.014B*53 0.077B*54 0B*55 0.043B*56 0B*57 0.014B*58 0.063B*59 0B*67 0B*73 0B*78 0B*81 0Cw*01 0.063Cw*02 0.014Cw*0302 0.106Cw*0303 0Cw*04 0.231Cw*05 0.014Cw*06 0.053Cw*0602 0.053Cw*07 0.159Cw*0701 0.034Cw*0702 0.125Cw*0703 0Cw*0704 0Cw*08 0.015Cw*0801 0.005

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HLA allele Gene frequencyCw*0802 0.01Cw*12 0.086Cw*1202 0.014Cw*1203 0.072Cw*14 0.058Cw*15 0.183Cw*16 0.005Cw*1601 0Cw*1602 0.005Cw*17 0.01DQB1*02 0.4DQB1*03 0.11DQB1*0301 0.075DQB1*0302 0.02DQB1*030302 0.005DQB1*0305 0.01DQB1*04 0.015DQB1*05 0.34DQB1*06 0.07DRB1*01 0.135DRB1*03 0.345DRB1*04 0DRB1*07 0.02DRB1*08 0.005DRB1*09 0DRB1*10 0.025DRB1*1001 0.025DRB1*11 0.11DRB1*12 0DRB1*13 0.035DRB1*1302 0DRB1*14 0.02DRB1*15 0.135DRB1*16 0.17

HLA haplotype Frequency (%)A*01-B*07 1.9A*02-B*35-Cw*04 3.9A*02-B*51 6.2A*02-B*51-DRB1*16 3.5A*03-B*35 2.5A*03-B*35-Cw*04 2.4A*11-B*08-Cw*0702 2.6A*11-B*08-DRB1*03 2.6A*11-B*35-Cw*04 2.9A*11-B*35-DRB1*01 3A*11-B*40 10A*11-B*40-DRB1*16 6.4A*11-B*40-Cw*15 6A*11-B*53-DRB1*03 2.5A*11-B*55-Cw*01 2.4A*2601-B*08 2.5A*30-B*53 2.4A*30-B*53-DRB1*03 2.5A*3201-B*35-DRB1*03 2.5A*33-B*58 2.4A*33-B*58-Cw*03 2.9

HLA haplotype Frequency (%)B*08-Cw*0702 9.1B*35-Cw*04 12.5B*40-Cw*15 10.9B*53-Cw*04 6.2B*58-Cw*03 5.3DRB1*01-DQB1*05 13.5DRB1*03-DQB1*02 32DRB1*11-DQB1*0301/04 5.5DRB1*15-DQB1*0601 5.5DRB1*16-DQB1*05 15

HLA-A, -B, -Cw, -DQB1 and

-DRB1 Allele Frequencies in a

Population from Balochistan

Province of Pakistan

A. Mohyuddin*, S. Khaliq, Q. Ayuband S.Q. MehdiBiomedical and Genetic Engineering Laboratories,Islamabad, PakistanE-mail: *aishamoh@isb.comsats.net.pk

This population from the Balochistan Province of Pakistan,Latitude 30–31N Longitude 66–67E consisted of 66 individ-uals. The individuals were drawn from a rural environmentwhere the grandparents had also lived and alleles were deter-mined using sequence specific primers. Oral traditions placethe origin of the Baloch tribes in Aleppo, Syria and they aresupposed to have migrated to Pakistan through Iran. Theyspeak Balochi, an Indo-European language. The results havepreviously been published in Tissue Antigens 59, 492–501,2002. The following alleles could not be distinguished:A*0301/03N (frequency entered under A*0301) A*2402/09N/11N (entered under A*2402) Cw*0302/04 (entered un-der Cw*0302) Cw*0801/03 (entered under Cw*0801)DQB1*0301/04 (entered under DQB1*0301). Human Im-munology 65, 1040–1042 (2004). © American Society forHistocompatibility and Immunogenetics, 2004. Published byElsevier Inc.

Allele Gene frequencyA*01 0.03A*0101 0.03A*0102 0A*02 0.135A*0201 0.095A*0202 0A*0203 0.008A*0204 0A*0205 0A*0206 0.016

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Human Immunology 65 (2004)0198-8859/04/$–see front matter© American Society for Histocompatibility and Immunogenetics, 2004

Published by Elsevier Inc.