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THE IMPACT OF COVID-19 ON HIV PATIENT TREATMENT – A Year in Review WAVE #4 From March to December 2020, Ipsos ran multiple waves of the HIV COVID-19 Impact study to understand how the pandemic was affecting HIV patient caseload, management, and treatment management in the US. At the end of the year, the 4th wave of our study revealed another reported decrease in HIV patient caseloads and a return to greater uncertainty, by participating physicians. www.ipsos.com ABOUT THE IPSOS HEALTHCARE SERVICE LINE Ipsos partners with pharmaceutical, biotech and medical device manufacturers to inspire better healthcare. Operating in over 50 countries, our 1000+ experts support key business decisions for our clients throughout the commercial lifecycle, from early-stage strategy, to launch, to performance optimization. We do this through a uniquely integrated combination of therapeutic and market expertise, gold standard real world evidence, and market-leading custom research approaches – all underpinned by a global footprint and unprecedented access to today’s healthcare stakeholders. Source: Ipsos US Impact of COVID-19 HIV Study Fieldwork Dates: March 30, 2020 to April 8, 2020 (Wave 1); May 7, 2020 to May 20, 2020 (Wave 2); July 6, 2020 to July 13, 2020 (Wave 3); December 1, 2020 to December 17, 2020 (Wave 4) Country: US Sample Size: ~100 doctors Methodology: All data collected online External source *Centers for Disease Control and Prevention, COVID-19 Response. COVID-19 Case Surveillance Public Data Access, Summary, and Limitations (version date: February 28, 2021). Date accessed: March 29, 2021. Questions asked: % recorded change in weekly HIV patient caseload » Prior to the first wave of COVID-19, how many HIV patients did you see in a typical week? » In the last week, how many HIV patients have you managed both in person and by telemedicine (where electronic or telecommunication is used to provide care and services remotely) » Is this [INCREASE/DECREASE] in the number of HIV patients you saw in the last week vs what is typical (prior to the first wave of COVID-19), related to the COVID-19 outbreak? Anticipated future decrease vs increase in HIV caseload » How do you expect your HIV patient load to change in upcoming weeks? » Why do you say this? © Ipsos 2021, all rights reserved. Research conducted in the US. IPSOS REAL WORLD EVIDENCE With the emergency approval of several vaccines and the relaxation of state restrictions at the end of 2020, the future impact of COVID-19 on HIV patients remains to be seen. Contact us to uncover the ongoing impact of COVID-19 on real-world patient management practice: [email protected] ABOUT THE RESEARCH WAVE #1 At the beginning of the pandemic, participating physicians stated they saw their HIV patient load decrease and expected this decrease to continue in the coming weeks. *’Strongly agreed’ is defined as a score of 6 or 7 on a 1-7 rating scale n = 100 physicians 10,000 0 FW PERIOD 03/30 - 04/08 MARCH 2020 APRIL 2020 *7-day Moving Avg. COVID-19 Cases 20,000 30,000 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 7 6 5 4 3 2 1 Percentage reported change in weekly patient caseload “My HIV patients are cancelling of participating physicians strongly agreed* with this statement 71% All pts HIV pts -34% -45% Decrease Increase No change Don’t know Expected reported change in HIV caseload in coming weeks 51% 26% 18% 6% scheduled check-up appointments” WAVE #3 As summer set in, so did positivity, with almost a third of participating physicians expecting their caseload to increase and a lower proportion of physicians compared to previous waves highlighting patients cancelling appointments *’Strongly agreed’ is defined as a score of 6 or 7 on a 1-7 rating scale n = 100 physicians 30,000 20,000 10,000 0 FW PERIOD 07/06 - 07/13 JUNE 2020 APRIL 2020 *7-day Moving Avg. COVID-19 Cases 60,000 50,000 40,000 70,000 23 24 25 26 27 28 29 30 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 22 21 20 19 18 17 16 Percentage reported change in weekly patient caseload “My HIV patients are cancelling of participating physicians strongly agreed* with this statement 50% All pts HIV pts -30% -33% Decrease Increase No change Don’t know Expected reported change in HIV caseload in coming weeks 36% 14% 19% 31% scheduled check-up appointments” *’Strongly agreed’ is defined as a score of 6 or 7 on a 1-7 rating scale. n = 100 physicians 0 FW PERIOD 12/01 - 12/17 Pfizer-BioNTech COVID-19 Vaccine Moderna COVID-19 Vaccine 93% of participating physicians reported they are recommending COVID-19 vaccine to HIV patients NOVEMBER 2020 DECEMBER 2020 *7-day Moving Avg. COVID-19 Cases 300,000 100,000 200,000 22 23 24 25 26 27 28 29 30 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 21 20 19 18 17 16 15 Percentage reported change in weekly patient caseload “My HIV patients are cancelling of participating physicians strongly agreed* with this statement 41% All pts HIV pts -16% -30% Decrease Increase No change Don’t know Expected reported change in HIV caseload in coming weeks 55% 6% 13% 26% scheduled check-up appointments” WAVE #2 A month later, a quarter of participating physicians were uncertain of what the coming weeks held while almost half expected no change. Percentage reported change in weekly patient caseload “My HIV patients are cancelling of participating physicians strongly agreed* with this statement 59% All pts HIV pts Expected reported change in HIV caseload in coming weeks scheduled check-up appointments” -35% -29% Decrease Increase No change Don’t know 42% 24% 26% 8% *’Strongly agreed’ is defined as a score of 6 or 7 on a 1-7 rating scale. n = 100 physicians 10,000 0 FW PERIOD 05/07 - 05/20 JUNE 2020 APRIL 2020 MAY 2020 *7-day Moving Avg. COVID-19 Cases 20,000 30,000 30 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 1 2 3 4 5 6 7 29 28 27 26 25 24 23

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THE IMPACT OF COVID-19 ON HIV PATIENT TREATMENT – A Year in Review

WAVE #4

From March to December 2020, Ipsos ran multiple waves of the HIV COVID-19 Impact study to understand how the pandemic was affecting HIV patient caseload, management, and treatment management in the US.

At the end of the year, the 4th wave of our study revealed another reported decrease in HIV patient caseloads and a return to greater uncertainty, by participating physicians.

www.ipsos.com

ABOUT THE IPSOS HEALTHCARE SERVICE LINEIpsos partners with pharmaceutical, biotech and medical device manufacturers to inspire better healthcare. Operating in over 50 countries, our 1000+ experts support key business decisions for our clients throughout the commercial lifecycle, from early-stage strategy, to launch, to performance optimization. We do this through a uniquely integrated combination of therapeutic and market expertise, gold standard real world evidence, and market-leading custom research approaches – all underpinned by a global footprint and unprecedented access to today’s healthcare stakeholders.

Source: Ipsos US Impact of COVID-19 HIV Study

Fieldwork Dates: March 30, 2020 to April 8, 2020

(Wave 1); May 7, 2020 to May 20, 2020 (Wave 2); July 6, 2020 to July 13, 2020 (Wave 3);

December 1, 2020 to December 17, 2020 (Wave 4)

Country: US

Sample Size: ~100 doctors

Methodology: All data collected online

External source

* Centers for Disease Control and Prevention, COVID-19 Response. COVID-19 Case

Surveillance Public Data Access, Summary, and Limitations (version date: February 28,

2021). Date accessed: March 29, 2021.

Questions asked:

% recorded change in weekly HIV patient caseload

» Prior to the first wave of COVID-19, how many HIV patients did you see in a typical week?

» In the last week, how many HIV patients have you managed both in person and by

telemedicine (where electronic or telecommunication is used to provide care and

services remotely)

» Is this [INCREASE/DECREASE] in the number of HIV patients you saw in the last week vs

what is typical (prior to the first wave of COVID-19), related to the COVID-19 outbreak?

Anticipated future decrease vs increase in HIV caseload

» How do you expect your HIV patient load to change in upcoming weeks?

» Why do you say this?

© Ipsos 2021, all rights reserved. Research conducted in the US.

IPSOSREAL WORLD EVIDENCE

With the emergency approval of several vaccines and the relaxation of state restrictions at the end of 2020, the future impact of COVID-19 on HIV patients remains to be seen.

Contact us to uncover the ongoing impact of COVID-19 on real-world patient management practice: [email protected]

ABOUT THE RESEARCH

WAVE #1 At the beginning of the pandemic, participating physicians stated they saw their HIV patient load decrease and expected this decrease to continue in the coming weeks.

*’Strongly agreed’ is defined as a score of 6 or 7 on a 1-7 rating scalen = 100 physicians

10,000

0

FW PERIOD 03/30 - 04/08

MARCH 2020 APRIL 2020

*7-d

ay M

ovin

g Av

g.

CO

VID

-19

Cas

es

20,000

30,000

8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 1 2 3 4 5 6 7 8 9 10 11 12 13 14 157654321

Percentage reported change in weekly patient caseload

“My HIV patients are cancelling

of participating physicians strongly agreed* with this statement

71%

All pts HIV pts

-34%

-45%

Decrease

Increase No change

Don’t know

Expected reported change in HIV caseload in coming weeks

51%

26%

18%6%

scheduled check-up appointments”

WAVE #3 As summer set in, so did positivity, with almost a third of participating physicians expecting their caseload to increase and a lower proportion of physicians compared to previous waves highlighting patients cancelling appointments

*’Strongly agreed’ is defined as a score of 6 or 7 on a 1-7 rating scalen = 100 physicians

30,000

20,000

10,000

0

FW PERIOD 07/06 - 07/13

JUNE 2020 APRIL 2020

*7-d

ay M

ovin

g Av

g.

CO

VID

-19

Cas

es

60,000

50,000

40,000

70,000

23 24 25 26 27 28 29 30 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 3122212019181716

Percentage reported change in weekly patient caseload

“My HIV patients are cancelling

of participating physicians strongly agreed* with this statement

50%

All pts HIV pts

-30%-33%

Decrease

Increase

No change

Don’t know

Expected reported change in HIV caseload in coming weeks

36%

14%

19%

31%

scheduled check-up appointments”

*’Strongly agreed’ is defined as a score of 6 or 7 on a 1-7 rating scale. n = 100 physicians

0

FW PERIOD 12/01 - 12/17

Pfizer-BioNTech COVID-19 Vaccine

Moderna COVID-19 Vaccine93% of participating physicians reported they are

recommending COVID-19 vaccine to HIV patients

NOVEMBER 2020 DECEMBER 2020

*7-d

ay M

ovin

g Av

g. C

OVI

D-1

9 C

ases

300,000

100,000

200,000

22 23 24 25 26 27 28 29 30 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 3021201918171615

Percentage reported change in weekly patient caseload

“My HIV patients are cancelling

of participating physicians strongly agreed* with this statement

41%

All pts HIV pts

-16%

-30%

Decrease

Increase

No change

Don’t know

Expected reported change in HIV caseload in coming weeks

55%6%

13%

26%

scheduled check-up appointments”

WAVE #2 A month later, a quarter of participating physicians were uncertain of what the coming weeks held while almost half expected no change.

Percentage reported change in weekly patient caseload

“My HIV patients are cancelling

of participating physicians strongly agreed* with this statement

59%

All pts HIV pts

Expected reported change in HIV caseload in coming weeks scheduled check-up appointments”

-35%-29%

Decrease

Increase

No change

Don’t know

42%

24%

26%

8%

* ’Strongly agreed’ is defined as a score of 6 or 7 on a 1-7 rating scale. n = 100 physicians

10,000

0

FW PERIOD 05/07 - 05/20

JUNE 2020APRIL 2020 MAY 2020

*7-d

ay M

ovin

g Av

g.

CO

VID

-19

Cas

es

20,000

30,000

30 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 1 2 3 4 5 6 729282726252423