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Hematopoiesis (The formation of Blood Cells)

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Page 1: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Hematopoiesis (The formation of Blood Cells)

Page 2: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Where Does it Happen?

• Occurs in the Red Bone Marrow• Red Bone Marrow is Found in the flat

bones of the:1. Pelvis2. Ribs3. Sternum4. Ends of the Femur and Humerus in adults.

Page 3: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

How is it controlled?

• Each blood cell type is produced according to need

• Levels of the hormone Erythropoietin (EPO) control the rate of RBC production

• EPO is produced by the kidneys

Page 4: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

How does EPO work?

• We always have a little EPO flowing through us to ensure constant RBC production

• If Oxygen levels fall, levels of EPO rise and more RBC’s are produced

• The increase in EPO stimulates the red bone marrow to produce the new cells

• High levels of oxygen in the blood will lower the amount of EPO and slow down RBC production

Page 5: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

The Hematocytoblast

• Common stem cell that gives rise to all the formed elements of blood

• Located in the red bone marrow• Forms two types of cells1. Lymphoid Stem cell- produces all lymphocytes2. Myeloid Stem Cell- produces all other formed elements (RBC’s plasma)

Page 6: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:
Page 7: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Formation and Destruction of Red Blood Cells

Process Diagrams Step-by-Step

Copyright © 2007 by John Wiley & Sons, Inc.

Page 8: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Red blood celldeath andphagocytosis

Key:in blood

in bile

Macrophage inspleen, liver, orred bone marrow

1

Page 9: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Globin

Red blood celldeath andphagocytosis

Key:in blood

in bile

Macrophage inspleen, liver, orred bone marrow

Heme2

1

Page 10: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Red blood celldeath andphagocytosis

Key:in blood

in bile

Macrophage inspleen, liver, orred bone marrow

Heme

3

2

1

Page 11: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Red blood celldeath andphagocytosis

Transferrin

Fe3+

Key:in blood

in bile

Macrophage inspleen, liver, orred bone marrow

Heme

4

3

2

1

Page 12: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Red blood celldeath andphagocytosis

Transferrin

Fe3+

Liver

Key:in blood

in bile

Macrophage inspleen, liver, orred bone marrow

FerritinHeme

54

3

2

1

Page 13: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Red blood celldeath andphagocytosis

Transferrin

Fe3+

Fe3+ Transferrin

Liver

Key:in blood

in bile

Macrophage inspleen, liver, orred bone marrow

FerritinHeme

654

3

2

1

Page 14: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Red blood celldeath andphagocytosis

Transferrin

Fe3+

Fe3+ Transferrin

Liver

+Globin

+Vitamin B12

+Erythopoietin

Key:in blood

in bile

Macrophage inspleen, liver, orred bone marrow

FerritinHeme Fe3+

7

654

3

2

1

Page 15: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Circulation for about120 days

Red blood celldeath andphagocytosis

Transferrin

Fe3+

Fe3+ Transferrin

Liver

+Globin

+Vitamin B12

+Erythopoietin

Key:in blood

in bile

Erythropoiesis inred bone marrow

Macrophage inspleen, liver, orred bone marrow

FerritinHeme Fe3+

8

7

654

3

2

1

Page 16: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Circulation for about120 days

Red blood celldeath andphagocytosis

Transferrin

Fe3+

Fe3+ Transferrin

Liver

+Globin

+Vitamin B12

+Erythopoietin

Key:in blood

in bile

Erythropoiesis inred bone marrow

Macrophage inspleen, liver, orred bone marrow

FerritinHeme

Biliverdin Bilirubin

Fe3+

9

8

7

654

3

2

1

Page 17: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Circulation for about120 days

Bilirubin

Red blood celldeath andphagocytosis

Transferrin

Fe3+

Fe3+ Transferrin

Liver

+Globin

+Vitamin B12

+Erythopoietin

Key:in blood

in bile

Erythropoiesis inred bone marrow

Macrophage inspleen, liver, orred bone marrow

FerritinHeme

Biliverdin Bilirubin

Fe3+

10

9

8

7

654

3

2

1

Page 18: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Stercobilin

Bilirubin

Urobilinogen

Feces

Smallintestine

Circulation for about120 days

Bacteria

Bilirubin

Red blood celldeath andphagocytosis

Transferrin

Fe3+

Fe3+ Transferrin

Liver

+Globin

+Vitamin B12

+Erythopoietin

Key:in blood

in bile

Erythropoiesis inred bone marrow

Macrophage inspleen, liver, orred bone marrow

FerritinHeme

Biliverdin Bilirubin

Fe3+

12

111

0

9

8

7

654

3

2

1

Page 19: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Urine

Stercobilin

Bilirubin

Urobilinogen

Feces

Smallintestine

Circulation for about120 days

Bacteria

Bilirubin

Red blood celldeath andphagocytosis

Transferrin

Fe3+

Fe3+ Transferrin

Liver

+Globin

+Vitamin B12

+Erythopoietin

Key:in blood

in bile

Erythropoiesis inred bone marrow

Kidney

Macrophage inspleen, liver, orred bone marrow

Ferritin

Urobilin

Heme

Biliverdin Bilirubin

Fe3+

13

12

111

0

9

8

7

654

3

2

1

Page 20: Hematopoiesis (The formation of Blood Cells). Where Does it Happen? Occurs in the Red Bone Marrow Red Bone Marrow is Found in the flat bones of the:

Aminoacids

Reused forprotein synthesisGlobin

Urine

Stercobilin

Bilirubin

Urobilinogen

Feces

Largeintestine

Smallintestine

Circulation for about120 days

Bacteria

Bilirubin

Red blood celldeath andphagocytosis

Transferrin

Fe3+

Fe3+ Transferrin

Liver

+Globin

+Vitamin B12

+Erythopoietin

Key:in blood

in bile

Erythropoiesis inred bone marrow

Kidney

Macrophage inspleen, liver, orred bone marrow

Ferritin

Urobilin

Heme

Biliverdin Bilirubin

Fe3+

14

13

12

111

0

9

8

7

654

3

2

1


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