head and neck tumor control probability: radiation doseᅢ까

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Accepted Manuscript Head and Neck Tumor Control Probability: Radiation Dose-Volume Effects in SBRT for Locally-Recurrent Previously-Irradiated Head and Neck Cancer John A. Vargo, MD, Vitali Moiseenko, PhD, Jimm Grimm, PhD, Jimmy Caudell, MD, David A. Clump, MD PhD, Ellen Yorke, PhD, Jinyu Xue, PhD, Yevgeniy Vinogradskiy, PhD, Eduardo G. Moros, PhD, Panayiotis Mavroidis, PhD, Sheena Jain, MD, Issam El Naqa, PhD, Lawrence B. Marks, MD, Dwight E. Heron, MD, MBA PII: S0360-3016(18)30107-X DOI: 10.1016/j.ijrobp.2018.01.044 Reference: ROB 24722 To appear in: International Journal of Radiation Oncology • Biology • Physics Received Date: 13 December 2017 Revised Date: 30 December 2017 Accepted Date: 10 January 2018 Please cite this article as: Vargo JA, Moiseenko V, Grimm J, Caudell J, Clump DA, Yorke E, Xue J, Vinogradskiy Y, Moros EG, Mavroidis P, Jain S, El Naqa I, Marks LB, Heron DE, Head and Neck Tumor Control Probability: Radiation Dose-Volume Effects in SBRT for Locally-Recurrent Previously-Irradiated Head and Neck Cancer, International Journal of Radiation Oncology • Biology • Physics (2018), doi: 10.1016/j.ijrobp.2018.01.044. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Page 1: Head and Neck Tumor Control Probability: Radiation Doseᅢ까

Accepted Manuscript

Head and Neck Tumor Control Probability: Radiation Dose-Volume Effects in SBRTfor Locally-Recurrent Previously-Irradiated Head and Neck Cancer

John A. Vargo, MD, Vitali Moiseenko, PhD, Jimm Grimm, PhD, Jimmy Caudell, MD,David A. Clump, MD PhD, Ellen Yorke, PhD, Jinyu Xue, PhD, Yevgeniy Vinogradskiy,PhD, Eduardo G. Moros, PhD, Panayiotis Mavroidis, PhD, Sheena Jain, MD, Issam ElNaqa, PhD, Lawrence B. Marks, MD, Dwight E. Heron, MD, MBA

PII: S0360-3016(18)30107-X

DOI: 10.1016/j.ijrobp.2018.01.044

Reference: ROB 24722

To appear in: International Journal of Radiation Oncology • Biology • Physics

Received Date: 13 December 2017

Revised Date: 30 December 2017

Accepted Date: 10 January 2018

Please cite this article as: Vargo JA, Moiseenko V, Grimm J, Caudell J, Clump DA, Yorke E, Xue J,Vinogradskiy Y, Moros EG, Mavroidis P, Jain S, El Naqa I, Marks LB, Heron DE, Head and Neck TumorControl Probability: Radiation Dose-Volume Effects in SBRT for Locally-Recurrent Previously-IrradiatedHead and Neck Cancer, International Journal of Radiation Oncology • Biology • Physics (2018), doi:10.1016/j.ijrobp.2018.01.044.

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service toour customers we are providing this early version of the manuscript. The manuscript will undergocopyediting, typesetting, and review of the resulting proof before it is published in its final form. Pleasenote that during the production process errors may be discovered which could affect the content, and alllegal disclaimers that apply to the journal pertain.

Page 2: Head and Neck Tumor Control Probability: Radiation Doseᅢ까

MANUSCRIP

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ACCEPTED

ACCEPTED MANUSCRIPT

HyTEC: Organ-Specific Paper Head and Neck TCP

Head and Neck Tumor Control Probability: Radiation Dose-Volume Effects in SBRT for Locally-Recurrent Previously-Irradiated Head and Neck Cancer

John A Vargo MD,* Vitali Moiseenko PhD,† Jimm Grimm PhD,‡ Jimmy Caudell MD,§ David A Clump MD PhD,* Ellen Yorke PhD∥ Jinyu Xue PhD,¶ Yevgeniy Vinogradskiy PhD,# Eduardo G. Moros PhD,§ Panayiotis Mavroidis PhD, ** Sheena Jain MD,†† Issam El Naqa, PhD,‡‡ Lawrence B. Marks MD,** Dwight E. Heron, MD, MBA*

*Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA.

†Radiation Medicine & Applied Sciences, University of California, San Diego, La Jolla, CA

‡Dept. Radiation Oncology and Mol. Rad. Sciences, Johns Hopkins University, Baltimore, MD

§H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

∥Memorial Sloan Kettering Cancer Center, New York, NY

¶Department of Radiation Oncology, MD Anderson Cancer Center at Cooper University Hospital, Camden, NJ

#Department of Radiation Oncology, University of Colorado Denver, Aurora, CO

**Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC

††Bott Cancer Center, Holy Redeemer Hospital, Meadowbrook, PA

‡‡University of Michigan, Ann Arbor, MI

Corresponding Author: Dwight E. Heron, MD, MBA, FACRO, FACR

UPMC Cancer Pavilion 5150 Centre Ave Pittsburgh, PA 15232