NANOMATERIALS FOR DRUG DELIVERY AND THERANOSTICS

Gold Nanoparticles

Silver Nanoparticles

Iron Oxide Nanoparticles

Carbon Nanotubes

Fluorescent Nanodiamonds

Silica Nanobeads

Nanomaterials for Drug Delivery and Theranostics

NANOMATERIALS

A)

B)

Fe3O4nanoparticles

MMNA DOX-MMNA

6 h

180 °C Doxorubicin(DOX)

Paclitaxel (TXL)

DPPC:Chol:DSPE-PEG2000

(5:2:2)DOX:TXL-LMMNA

ACMF pH

ACMF

in vitro thermo-chemotherapywith DOX:TXL-LMMNA in vitro

Dual drug release from LMMNA

Magneticnanoparticles

PEGlyated lipid layer

Day 0 Day 7Drugs targeting

In vivo biodistributionby imaging in nude mice

Targeting dual drugDOX:TXL-LMMNA

Nanoparticles of gold, silver, iron oxide, silica, and carbon find applications in bioimaging, biosensing and targeted drug delivery.1-4 Appropriate surface modification allows for the conjugation of nanoparticles to a wide range of biomolecules including peptides, antibodies, nucleic acids as well as therapeutic agents. Conjugation to highly specific affinity reagents can enable delivery of nanomaterials and preferential accumulation in the area of interest, leading to enhanced therapeutic efficacy and reduced cytotoxicity. Aldrich® Materials Science offers a wide selection of nanomaterials for biomedical applications.

References1. Hu, X.; Liu, S. Dalton Trans. 2015, 44, 3904.

2. Wu,X.; Gao, Y.; Dong, C-M. RSC Adv. 2015, 5, 13787.

3. Xie, J.; Jon, S. Theronastics 2012, 2, 122.

4. Nigam, S.; Pradhan, L.; Bahadur, D. Material Matters, 2015, 10, 29.

TARGET ID &VALIDATION

LEADDISCOVERY

LEADOPTIMIZATION

PRE-CLINICALDEVELOPMENT

CLINICAL DEVELOPMENT

MANUFACTURING

TRANSLATIONAL RESEARCH SOLUTIONSNanomaterials for Drug Delivery is just one part of Sigma-Aldrich’s complete offer for academic Drug Discovery, a unique series of solutions that span Target ID & Validation through Pre-Clinical Development. Translational Medicine Solutions from Sigma-Aldrich are used by experts and non-experts alike to facilitate the cross-disciplinary research required for today’s drug discovery.

To learn more about solutions that cover the entire drug discovery workflow, visit

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Gold Nanoparticles Used for targeted drug delivery, cell tracking, photothermal therapy, immunoassays, and photocaustic imaging. Includes a variety of attachment chemistries for convenient attachment of biomolecules and other targets.

For a complete list of available materials, visit aldrich.com/gnp

Description Particle Size (nm) Prod. No.Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O 5 765260Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O 10 765295Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O 15 765317Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O 20 765333Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O 30 765368Amine functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O 40 765384Carboxylic acid functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O 10 765457Carboxylic acid functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O 20 765503Carboxylic acid functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O 40 765554Carboxylic acid functionalized nanoparticles, PEG 3000 coated, OD 50, dispersion in H2O 50 765570Silica-coated gold nanoparticles, OD 1, dispersion in H2O 5 747556Silica-coated gold nanoparticles, OD 1, dispersion in H2O 10 747564Silica-coated gold nanoparticles, OD 1, dispersion in H2O 20 747572Silica-coated gold nanorods, absorption/780 nm, dispersion in H2O 10 747971Silica-coated gold nanorods, absorption/808 nm, dispersion in H2O 10 747998Silica-coated gold nanorods, absorption/850 nm, dispersion in H2O 10 748005

Silver Nanoparticles Used for antifouling coating, bioimaging, hyperthermia, and thermally modulated drug release.

For a complete list of available materials, visit aldrich.com/snp

NanospheresDescription Surface Particle Size (nm) Prod. No.Nanospheres, 0.02 mg/mL in water PVP functionalized 10 795925Nanospheres, 0.02 mg/mL in 2 mM aqueous sodium citrate Citrate functionalized 30 796123Nanospheres, 0.02 mg/mL in water Lipoic acid functionalized 40 796204Nanospheres, 0.02 mg/mL in water PEG functionalized 50 796328Nanospheres, 0.02 mg/mL in water BPEI functionalized 60 796425

NanoplatesDescription Surface Resonance Wavelength (nm) Prod. No.Nanoplates, 0.02 mg/mL (in water with 5 mM sodium borate buffer) PVP functionalized 550 796476Nanoplates, 0.02 mg/mL (in water with 5 mM sodium borate buffer) PVP functionalized 750 796492Nanoplates, 0.02 mg/mL (in water with 5 mM sodium borate buffer) PVP functionalized 850 796506

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Iron Oxide Nanoparticles Used as magnetic resonance imaging (MRI) contrast agents, gene carriers for gene therapy, therapeutic agents for hyperthermia-based cancer treatments, magnetic sensing probes for in vitro diagnostics, and target-specific drug delivery. Includes conjugation chemistry for convenient attachment to biomolecules and other targets.

For a complete list of available materials, visit aldrich.com/ionp

Description Concentration Particle Size (nm) Prod. No.Amine functionalized nanoparticles 1 mg/mL in H2O 5 747343Amine functionalized nanoparticles 1 mg/mL in H2O 10 747300Amine functionalized nanoparticles 1 mg/mL in H2O 30 747327Biotin functionalized nanoparticles 1 mg/mL in H2O 5 747416Biotin functionalized nanoparticles 1 mg/mL in H2O 10 747424Biotin functionalized nanoparticles 1 mg/mL in H2O 30 747432Carboxylic Acid functionalized nanoparticles 5 mg/mL in H2O 10 747254Carboxylic Acid functionalized nanoparticles 5 mg/mL in H2O 30 747335PEG functionalized nanoparticles 1 mg/mL in H2O 5 790508PEG functionalized nanoparticles 1 mg/mL in H2O 10 747319PEG functionalized nanoparticles 1 mg/mL in H2O 30 747408N-succinimidyl ester functionalized nanopowder — 5 747440N-succinimidyl ester functionalized nanopowder — 10 747459N-succinimidyl ester functionalized nanopowder — 30 747467

Carbon NanotubesUsed as molecular transporters in drug delivery systems and near-infrared (NIR) imaging agents.

For a complete list of available materials, visit aldrich.com/cnt

Description Bundle Dimensions Purity (%) Prod. No.Carbon nanotube, single-walled, carboxylic acid functionalized D 4–5 nm × L 0.5–1.5 μm >90 652490Carbon nanotube, multi-walled, carboxylic acid functionalized D 9.5 nm × L 1.5 μm >80 755125Carbon nanotube, single-walled, poly(ethylene glycol) functionalized D 4–5 nm × L 0.5–0.6 μm >80 652474Carbon nanotube, single-walled, amide functionalized D 4–6 nm × L 0.7–1.0 μm >90 685380Carbon nanotube, single-walled, octadecylamine functionalized D 2–10 nm × L 0.5–2 μm 80–90 652482Carbon nanotube, single-walled, polyaminobenzene sulfonic acid functionalized D 1.1 nm × L 0.5–1.0 μm 75-85 639230

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Fluorescent Nanodiamonds Used for diagnostics, photoacoustic imaging, biolabeling, and drug delivery.

For a complete list of available materials, visit aldrich.com/nanobiomed

Description Concentration Particle Size (nm) Prod. No.>300 nitrogen-vacancy center per particle 1 mg/mL 70 798169 >400 nitrogen-vacancy center per particle 1 mg/mL 100 798142>500 nitrogen-vacancy center per particle 1 mg/mL 90 798150>800 nitrogen-vacancy center per particle 1 mg/mL 100 798134>1,200 nitrogen-vacancy center per particle 1 mg/mL 120 798088

Silica NanobeadsUsed for flow cytometry, bioimaging, bioisensing, and diagnostics.

For a complete list of available materials, visit aldrich.com/nanobiomed

Description Emission Maximum (nm) Absorption Maximum (nm) Particle Size (nm) Prod. No.Fluorescent nanobeads 590 555 25 797928Fluorescent nanobeads 590 555 50 797936Fluorescent nanobeads 590 555 90 797898Fluorescent nanobeads 590 555 120 797863

Translating Polymer Science for Drug Delivery

POLYMERIC DRUG DELIVERY TECHNIQUES

Request your copy online at Aldrich.com/ddtechnique

A guide to drug delivery solutions using polymers for controlled release, targeted drug delivery and solubility enhancement.

yy Step-by-step methods written by drug delivery experts highlighting polymer-based methods to solve the most important drug delivery challengesyy Solutions for:

- Small molecules

- Nucleic acids

- Proteins

yy Key technologies: - Drug conjugation and PEGylation

- Biodegradable nanoparticles and micelles

- RAFT polymeric carriers for ADCs

- Dendrons

- Responsive drug delivery systems

- Polymers for oligonucleotide delivery

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