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The 4 th Industrial Revolu3on and Developing Countries I8y Islam CEO Miup BD [email protected] +8801730058920 +447817932685 Presented at Consor,um for the 4th Revolu,on | Execu,ve Briefing Day (#C4IR) Cambridge, UK 2-3 February 2017 | www.cir-strategy.com/events

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The4thIndustrialRevolu3onandDevelopingCountries

I8yIslam

CEOMiupBD

[email protected]

+8801730058920+447817932685

PresentedatConsor,umforthe4thRevolu,on|Execu,veBriefingDay(#C4IR)Cambridge,UK2-3February2017|www.cir-strategy.com/events

Key Themes

• The4thIndustrialRevolu3onwillaccelerateglobaliza3on• DevelopingCountrieswillbethenewdriverofinnova3on• ReverseTechnologicalDiffusion• CaseStudy1:MiupHealthAI• CaseStudy2:BracX/DeIaDisrup3veTechnologiesFund

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

MiupHealthAr3ficialIntelligenceSystem(AIS)I8yIslamCEO,MiupBangladesh

Doctor for Everyone

Miup AI Health System

RiskAssessment

TMI: Too Much Informa>on

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-98521145

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-98521147

The Opportunity: Using AI in BD Healthcare

•  Technology,andspecificallytheapplica,onofAr,ficialIntelligence(AI)canplayanimportantroleinachieving health goals, bridging the gap between resource limita,ons and allowing con,nuedimprovementinhealthcaredelivery.

•  Weseethepoten,alforadap,ngandleveragingtherapidimprovementsincogni,vecompu,ngandAI tohelpdeliverhigherquality andmore cost effec,vehealth services in lessdeveloped countriessuchasBangladesh.

•  InthecaseofBangladesh,thenumberoftrainedmedicalpersonnelistoolowforadequatecoverageofthewholepopula,on.Thereareonlyaround3.6physiciansand1nurseper10,000individuals.

•  This is aggravated by the geographical misdistribu,on of the staff, with only 16% of the doctorsopera,nginruralfacili,es.

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

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USING MEDICAL DIAGNOSIS AI CAN SOLVE MANY ISSUES

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-98521149

Mobile Health Apps Enjoying Rapid Growth

•  T h e g l o b a l m a r k e t f o rh e a l t h c a r e , w h i c h w a ses,matedtobeworth$10bnin2015,isforecasttogrowat15%annually to reach $ 31 bn by2020.

•  The global market for AI inhealth is forecast by Frost &Sullivan to increase almost tenfoldfrom$633.8millionin2014to$6,662.2millionin2021.

•  Mobile Health Apps havebecome increasingly popularand effec,ve in developedcountries.

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211410

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211411

What is Health AI?

Our system: Bayesian Ar>ficial Intelligence with input of Doctors decision making process of Bangladesh and Developed countries like Japan

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211412

Conven>onal Medical Diagnosis by Medical Doctor

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211413

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211414

MIUP AI: The Four Key Product Offerings

ProductName Dr.Miup

Category MedicalApp

Opera3ngSystemAndroid&IOSLaunch 2017Language English&Bangla

Target

1.   Bangladeshlowerincomegroup(viahealthcareworker)

2.   Bangladeshupper&middleclass

CheckSymptoms

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

ProductOverview

MainFunc3ons Details

SymptomChecker Symptomcheckergivesyoualistofpossiblediagnosesbasedontheinforma,onyouenter.Theinforma,onincludestheuser-expressedsymptoms,age,gender,andseriesofques,onsaboutthesymptoms.

PDKCheckup&RiskAssessment

EvaluatesthechronicdiseaseriskonthebasisofthetestvaluesfromPDKandmedicalques,onnaire.Thesystemcategorizesthehealthcondi,onto4riskstagesandreportstheindividual'shealthstatus.Forthepeoplewith:Highhealthrisk-themachinedirectsthepa,enttoseeadoctor.Moderaterisktolow-themachinewilladvisetheusertobehealthierbycommen,ngontheirac,vi,es,exerciserou,ne,diet,sleeppaeernandotherlifestyle,ps.Norisk-noadviserequired.

Book/ConsultDoctor Userscanbookanappointmentwiththedoctorthroughvideochat/inpersonthroughahospitalvisit.Achatfunc,onisalsoavailableforuserstoaskques,onstomedicalprofessionals.

Gene3cTes3ngThesystemwillanalyzethegene,cmakeupofan individual’sgenomethroughabuccalswabandthenprovidetheuserwithareportthatwillsupporttheirdecisionmakingprocessfortheirhealthandwell-being.

Addi3onalFeatures MedicalDic,onaryMySchedule–trackappointments

ProductComponents

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211417

1. The Symptom Checker

Answer the medical questionnaire

Choose the body part where they have a symptom

3-step for symptom checker Choose 1 Answer 2 Result 3

A list of probable diseases displayed. If urgent an alert is

sent to see a doctor.

CheckSymptomsCheckSymptomsCheckSymptoms

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

SymptomChecker

§  The Symptom checker gives you a list of possible diagnoses based on the information the user has entered. §  Patient specific entries

include: age, gender, and series of questions about the symptoms

Selectthepartofthebodypartwhereyouhaveasymptom

Answertheques,onnairetoevaluatepoten,aldiseaseriskforyoursymptoms

CheckSymptomsCheckSymptoms

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211420

2. PDK Checkup & Risk Assessment

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

MajorDiseasesinBangladesh&Cost

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Major Diseases in Bangladesh

Sl. Disease Disease-Specific Required Tests

Cost of Test

1 Lower Respiratory Infections CBC & CXR P/A View 600

2 Chronic Obstructive Pulmonary Disease CBC & CXR P/A View 600

3 Ischemic Heart Disease ECG, Trponin I, CK-MB, Lipid Profile 2500

4 Stroke CT Scan of Brain 2500 5 Tuberculosis CBC, CXR PA view, MT 800

6 Diabetes FBS, 2ABF, HbA1c, S. Creatinine, Lipid Profile 1600

7 Cirrhosis USG of HBS, Alk Pho, Acitic fluid 1000

8 Neonatal Encephalopathy CSF Study 300 9 Preterm Birth Complications

10 Hypertension ECG, S. Creatinie, Lipid Profile 1000

11 Hyperlipidemia Lipid Profile 600

12 Cardiovascular Diseases ECG, Lipid Profile, RBS, S. Creatinine 1000

13 Cerebrovascular Diseases CT Scan of Brain 2500

14 Chronic Kidney Diseases S. Creatinine, Urea, Albmin, UA, Urine R/R 1000

15 Malaria ICT 300

16 Dengue NS1 Antigen, CBC, Anti Dengue Ab 1500

17 Filariasis CBC PBF, CXR PA 600 18 Leishmaniasis CBC, BM, 1200 19 Kala-azar ICT, CBC, BM 1500 20 STDs VDRL, TPHA 500

21 Hepatitis S. Blirubin, SGPT, SGOT, HBsAg, USG of HBS 1500

The tableon the rightshows some of themajor diseases inBangladesh and thecost of medical testsneeded to screen forsuchdiseases:

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

ZeroCost&LowCostTests

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RiskPredic3onSystemCanReduceMedicalCheckCost

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

Addi3onalMedicalTests $26.8 1,000 $26,750

Includes: InBDT: InDollar:

HbA1c[400] BDT400 $5.0

HDL[200] BDT200 $2.5

LDL[300] BDT200 $2.5

TG[200] BDT200 $2.5

Hb% BDT100 $1.3

TC BDT100 $1.3

DC BDT100 $1.3

ESR BDT100 $1.3

PC BDT100 $1.3

CBC[200] BDT200 $2.5

Crea3nine[70] BDT70 $0.9

BUN[70] BDT70 $0.9

AST[100] BDT100 $1.3

ALT[100] BDT100 $1.3

TotalBilirubin BDT100 $1.3

TotalCostBDT2,140 $26.8

Result 4

DataistransferredfromPDKtomiup

applica3on

ThePDKdeviceisusedtoregisterpa3entandrun

diagnos3ctests

4-step for risk assessment Patient Registration and PDK checkup

1 Data Transfer 2

Usersarecategorizedinto4riskcategories

Advice/ Suggestion 3

HEALTHADVICE

Theuserisprovidedhealthadvise.Ifhighriskthentheuserisdirectedtoseeadoctor(telemedicine/inpersonconsulta3on)

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

Past Approach to Health Reac>ve…Future Proac>ve

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211425

catch-health.org

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211426

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211427

3. Telemedicine

Schedule an appointment. Users can choose between a video

conference or in person hospital visit

Call or visit doctor in person

Choose a doctor from the database

3-step for Video consulting and/or hospital book

Choose 1 Book 2 Call/visit 3

OR

Basedontheresultsofthe

RiskAssessment,a

usercancommunicate

withadoctor

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

VideoConferencingFeatures

Videoconsul,ng

Chatfunc,onstoaskques,onstodoctor.

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211430

4. GeneMc TesMng

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211431

WHO2005GenomicsReport:"ThemajorargumentoftheGenomicsandWorldHealthReportisthatgene3cs,andevengenomics,shouldnotbeconsideredluxuriesbeyondthereachofdevelopingcountries.Rathertheyaretoolsthatpresentopportuni3esforaddressingthespecificneedsofthepoor,eitherthroughtechnologytransferorthroughthedevelopmentofendogenouscapacity.Forexample,besidesthevalueofgene3ctestsinprovidingservicesofimmediatepublichealthbenefit,thereportclaimsthatgene3cshasasecondadvantage:itlaysafounda3onforthedevelopmentofskillsandexper3seinDNA-basedtechniqueslikegenomics,openingthedoortoapowerfulresearchpla]ormwithpoten3allywideapplicabilityinthehealthsphereandbeyond.“

hep://www.who.int/genomics/FullReport.pdf

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-9852114

Gene3cTes3ng

WhatisPharmacogene8cs?

§  Technology that analyzes how gene,c makeup affects an individual’s response tomedica,on.

Whyshouldyoubetested?

§  Pharmacogene,c tes,ng is the cornerstone of personalized medicine. Determininghowwellyoumetabolizemedica,onraiseschancesofaposi,veoutcomeandreducespossibleadversedrugrelatedreac,ons.

Howdoesitwork?

§  PersonalizedMedicinestartswithabuccalswab,rubbedontheinsideofyourcheektocollectcells.

§  Your doctor will then get a detailed report that will help them make the mostinformeddecisionspossiblewhenprescribingyourmedica,ons.

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MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211433

Commercial Strategy

Business-to-Business Strategy

Whilewebelievethatpriori,zingaB2Cstrategymakessense,wealsoplantodevelopcustomizedB2Bversionsoftheappforanumberoftargetmarketsegments:

1.   BracHealth:WeproposeofferingaRiskAssessmentservicethroughouttheBRACnetworkini,allyviathe97,000BRAChealthworkersinbothurbanandruralareasusinganewlydevelopedPortableDiagnos,cKit(PDK)andadetailedques,onnaire.

2.   Pharmacists:AcustomisedversionofourmobilehealthappwillbeofferedtopharmacistsalongwithPDKs,whichwouldallowthemtoprovidebasichealthadviceandconnecttheircustomerstodoctorswhocandovideoconsulta,onsandgiveeprescrip,ons.

3.   RMGSector:Webelievethatifwecanpersuadeglobalgarmentbuyerstopriori,seworkerhealth,thenfactoryownerswillbecomemoreenthusias,caboutsponsoringandimprovingtheiremployeeshealth.Wealsoplantoofferhealthcer,fica,onforthosefactoriesthathavedonethehealthriskscreening.

4.   ProfessionalClinicalDiagnos3cSystem

MIUP Corporate Office: Suite 2, Celebration Point (5th floor), Plot – 03, Road – 113/A, Gulshan – 2, Dhaka-1212, Tel: (880)-2-985211434

Commercializa>on of Big Data • Bigcommercialopportunityistheaccumula,onofthe10million+bigdataset.

• Developingaclearstrategyformone,singthishealthbigdatawillbethekeytomaximizingtherevenuesandincreasedvalua,onoftheBRACMiupbusinessinthefuture.

•  Theincreasedvalua,onscompaniesinvolvedinHealthBigDataandAIisunderlinedbytheaggressiveacquisi,onstrategyofIBMwhichhasspentover$4bninthepast12months.

• CBInsightsiden,fied32companiesthatarealreadyapplyingmachinelearningtechniquesandpredic,veanaly,cstoreducedrugdiscovery,mes,providevirtualassistancetopa,ents,anddiagnoseailmentsbyprocessingmedicalimages,amongotherthings.The32startupsonthelisthaveraisedmorethan$530Minaggregatefunding.

Surge in Financing to Health AI/Big Data