from truth serum to anesthesia: the discovery and uses of ... · “from truth serum to anesthesia:...
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05/11/2015
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Thursday, November 12, 2015
“Chemistry of Addiction”
Anthony Rappé, Professor of Chemistry, Colorado State University
Darren Griffen, Professor of Genetics, University of Kent
Thursday, November 19, 2015
“Prodrugs in Drug Discovery”
John Higgins, Senior Principal Scientist and Network Technology Lead, Merck
Nicholas Meanwell, Executive Director, Discovery Chemistry, Bristol-Myers
Squibb
10
www.acs.org/acswebinars www.acs.org/acswebinars Slides available now! Recordings will be available to ACS members after one week
“From Truth Serum to Anesthesia: The Discovery and Uses of Sodium Thiopental”
Contact ACS Webinars at [email protected]
David Harwell Asst. Director of Industry Member Programs, ACS
Michael Matson Reservoir Engineer, Kinder Morgan CO 2
05/11/2015
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From Truth Serum to Anesthesia:
The Discovery and Uses of Sodium Thiopental
Michael Matson, Kinder Morgan
Remember, remember, the 5th of November, The gunpowder treason and plot…
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05/11/2015
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Johann Friedrich Wilhelm
Adolf von Baeyer
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Barbituric Acid
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05/11/2015
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Audience Survey Question
Where do barbiturates get their name?
ANSWER THE QUESTION ON BLUE SCREEN IN ONE MOMENT
• In honor of Adolf von Bayer’s girlfriend, Barbara
• The urea first used was concentrated from the urine of a dog named Barbara
• The molecule was discovered on the day of the Feast of Saint Barbara
• The urea first used was concentrated from the urine of a Munich barmaid named Barbara
Saint Barbara
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Barbital
Josef von Mering Hermann Emil Fischer
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Audience Survey Question
Where does the drug Veronal get its name?
ANSWER THE QUESTION ON BLUE SCREEN IN ONE MOMENT
• The drug makes you sleepy, and the city of Verona was considered the most tranquil city in Europe
• Von Mering was on vacation in Verona when he got a telegram from Emil Fischer about the drug’s discovery
• Stems from the Latin root “verum” meaning ‘truth’
• The discovery was celebrated over a bottle of wine made from veron grapes
05/11/2015
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Veronal
19 Obtained from the site http://www.wellcomeimages.org/ and is under the Creative Commons Attribution only l icense CC BY 4.0
20
Audience Survey Question
Which celebrity’s death was NOT due to barbiturate overdose?
ANSWER THE QUESTION ON BLUE SCREEN IN ONE MOMENT
• Judy Garland
• Jimi Hendrix
• Michael Jackson
• Marilyn Monroe
• None. All of the above died of barbiturate overdose.
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Nembutal
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Pentothal
22 Transferred from Flickr by User:JohnnyMrNinja using flickr2commons
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Liquid Anaesthetics
23 Credit: Science Museum, London. Wellcome Images [email protected] http://wellcomeimages.org
WWII
24
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Narcoanalysis
25 This is an image from the Nationaal Archief, the Dutch National Archives, and Spaarnestad Photo, donated in the context of a partnership program.
26
Audience Survey Question
Which of the following is true about “Truth Serum”?
ANSWER THE QUESTION ON BLUE SCREEN IN ONE MOMENT
• The term "truth serum" came onto the scene in the 1920’s.
• Confessions of guilt under the influence of truth serum were ruled in admissible in US courts in 1963.
• Scopolamine, Pentothal, Sodium Amytal, and Ethyl Alcohol have all been used as “truth serums.”
• “Truth serums” don’t insure the truth but instead disorient and create positive feelings that make lying more difficult.
• All of the above are true.
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Truth Serum
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Sodium Amytal
28 Credit: Science Museum, London. Wellcome Images [email protected] http://wellcomeimages.org
05/11/2015
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Lethal Injection
29
Hospira
30 This fi le is l icensed under the Creative Commons Attribution 3.0 Unsupported license. Attribution: Acherubini2020 at en.wikipedia
05/11/2015
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Propofol
31 "Ampoule prefilled JPN" by ignis - Own work. Licensed under CC BY-SA 3.0 via Wikimedia Commons - https://commons.wikimedia.org/wiki/File:Ampoule_prefilled_JPN.jpg#/media/File:Ampoule_prefilled_JPN.jpg
32
www.acs.org/acswebinars www.acs.org/acswebinars Slides available now! Recordings will be available to ACS members after one week
“From Truth Serum to Anesthesia: The Discovery and Uses of Sodium Thiopental”
Contact ACS Webinars at [email protected]
David Harwell Asst. Director of Industry Member Programs, ACS
Michael Matson Reservoir Engineer, Kinder Morgan CO 2
05/11/2015
17
Be a featured fan on an upcoming webinar! Write to us @ [email protected]
33
How has ACS Webinars benefited you?
®
“Advanced Pyrotechnics 2 was a great presentation. It
was well organized and covered a good deal of very
fundamental key descriptions about pyrotechnics. I
really appreciated Chris Mocella emphasizing clubs
and pyrotechnics organizations.”
Paul Smith,
Director of Lecture Demonstrations, Purdue University
Vice President, Pyrotechnics Guild International
34
facebook.com/acswebinars
@acswebinars
youtube.com/acswebinars
Search for “acswebinars” and connect!
05/11/2015
18
Benefits of ACS Membership
35 www.acs.org/2joinACS
Chemical & Engineering News (C&EN) The preeminent weekly news source.
NEW! Free Access to ACS Presentations on Demand® ACS Member only access to over 1,000 presentation recordings from recent ACS meetings and select events.
NEW! ACS Career Navigator Your source for leadership development, professional education, career services, and much more.
36
ACS Webinars does not endorse any products or
services. The views expressed in this
presentation are those of the presenter and do
not necessarily reflect the views or policies of the
American Chemical Society.
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Contact ACS Webinars ® at [email protected]
05/11/2015
19
Upcoming ACS Webinars www.acs.org/acswebinars
37
®
Contact ACS Webinars ® at [email protected]
Thursday, November 12, 2015
“Chemistry of Addiction”
Anthony Rappé, Professor of Chemistry, Colorado State University
Darren Griffen, Professor of Genetics, University of Kent
Thursday, November 19, 2015
“Prodrugs in Drug Discovery”
John Higgins, Senior Principal Scientist and Network Technology Lead, Merck
Nicholas Meanwell, Executive Director, Discovery Chemistry, Bristol-Myers
Squibb