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Enhanced Recovery After Surgery Program Yields Results, Broad Interest

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As pressure ramps up on perioperative teams to more efficiently and cost- effectively deliver better clinical outcomes, the UCSF Department of Anesthesia and Perioperative Care is playing a central role in successfully

meeting these challenges.The Enhanced Recovery After Surgery (ERAS) program incorporates best practice

guidelines in perioperative surgical care. Anesthesiologist Lee-lynn Chen, MD, and colorectal surgeon Ankit Sarin, MD, MHA, piloted this approach in colorectal surgery in 2013. Their success, as evidenced by patient outcomes measures, has spawned interest in developing ERAS pathways for other surgical disciplines, including gynecological oncology, benign gynecological procedures, orthopedic surgery and head and neck surgery.

Comprehensive Best Practices

Rooted in ideas developed in Europe, ERAS deploys a multidisciplinary team of surgeons, anesthesiologists, pain management specialists, nurses, dietitians and other professionals. Their goals are to optimize patients’ health prior to surgery, follow a set protocol for medications and fluid management during surgery and implement post-operative evidenced-based interventions that accelerate recovery following surgery. UCSF is one of the first medical centers in the US to test the ERAS concept

Department of Anesthesia and Perioperative CareAnesthesia

News

Fall 2015 | Vol. 14

Also in this issue: ■■ Message from the Chair: Michael Gropper, MD, PhD

■■ Ask the Expert: Marc Steurer, MD, DESA

■■ The Research Scholars Residency Track

■■ Research: Seeking Safer Ways to Anesthetize Newborns and Young Children

■■ Farewell to the Ambulatory Surgery Center

■■ VA Update: Using Data to Create Value-Based Care

■■ Staff and Faculty Highlights

■■ New Faculty and Residents

■■ Awards, Publications, Grants

Lee-lynn Chen, MD, at UCSF Medical Center

UCSF Department of Anesthesia and Perioperative Care | Anesthesia News | Fall 2015 | 1

in colorectal surgery and Chen sees it as the starting point for the development of a perioperative surgical home for a wide range of procedures.

On a monthly basis, the ERAS group reviews all aspects of the pathway and constantly updates the protocol. Prior to surgery, the perioperative team tries to optimize patients’ health through diet, exercise and medication management. “We might even send particularly frail patients to a rehabilitation clinic prior to surgery in order to improve their health status – allowing patients to start at a higher baseline,” says Chen.

For colorectal surgeries, an innovative, pre-operative bowel preparation for ERAS pathway patients includes drinking a clear sugary liquid for carbohydrate loading two hours prior to surgery. This method is unlike the traditional bowel preparation that required patients to not eat or drink in the eight hours before surgery.

“Some studies have shown this [ERAS protocol intervention] increases patient satisfaction, makes patients less catabolic, increases the motility of the bowels post-surgery, reduces postoperative ileus and improves fluid management,” says Chen. He adds that a better-prepared patient allows for following the best practice recommendation of using less than two liters of intraoperative fluids, as well as for using non-opiate pain medications to manage post-operative pain.

Most ERAS patients engage in eating solid foods and are up and about one day after surgery. In addition, patients are active participants in their recovery, drawing on audiovisual aids and written handouts. After discharge, they have convenient access to their medical team through an online patient portal and central phone number.

“The idea [of creating an ERAS pathway] is to standardize best practices and decrease variability, which results in improved outcomes. In our colorectal pilot, we decreased length of stay by approximately two days and decreased readmits,” says Chen. Both measures are widely accepted markers for reductions in complications.

In fact, patient postoperative pain scores were reduced, patient satisfaction improved and the ability to meet key milestones occurred more rapidly. “They eat sooner, walk sooner, have Foleys removed sooner…each milestone is moved up by a couple of days,” says Chen.

Expanding Across UCSF When the program demonstrated positive results in colorectal surgery, the door opened to expand to other services. ERAS began to grow as part of the Caring Wisely initiative at UCSF, which allowed for collaborations with the aforementioned surgical teams. And when the American Society of Anesthesiologists asked for participants to help study and refine the concept of a perioperative surgical home, the UCSF team began contributing its ERAS findings. ERAS is now a nationwide effort. ■

Enhanced Recovery After Surgery (ERAS) continued from previous page

The ERAS concept includes patient education prior to surgery, as depicted in this video on the UCSF Department of Surgery ERAS website: eras.surgery.ucsf.edu.


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many others. Hamilton also appointed Morley Singer to lead the new Intensive Care Unit. Our Department continues to lead or co-lead the ICU’s at SFGH, Moffitt/Long, and Mission Bay, with nearly 30 board-certified anesthesia intensivists. Under Hamilton’s stewardship, the Department thrived.

In 1984, Ron Miller became the Department’s 3rd Chair, leading an era of tremendous growth and scientific and educational achievement. Ron’s leadership established UCSF as the clear leader internationally in anesthesia research and education. In addition to Bill Young and Jeanine Wiener-Kronish, perhaps his most important recruit was Mark Rosen, who led the residency program for over 20 years, identifying and nurturing an extraordinary group of trainees, in addition to his own distinguished career in obstetric anesthesia. Mark’s key role is now in the capable hands of Manny Pardo, ably assisted by Melissa Patrick (see page 9).

In 2009, after 25 years of careful stewardship, Ron Miller handed the reins of the Department to Mervyn Maze, arriving from Imperial College in London. Mervyn continued to grow the Department, and added his own impressive research resume to our already robust programs. Importantly,

I am deeply honored to have been selected by Dean Talmadge King as the fifth Chair of the Department of

Anesthesia and Perioperative Care at UCSF. I have spent my entire career in the Department, arriving as a first-year resident in 1990, and look forward to finishing my career in San Francisco. In the last year, I have become a scholar of the history of the Department. Our legacy is storied, starting with the establishment of the Department of Anesthesia and Perioperative Care at UCSF when in 1958, Stuart Cullen was recruited to San Francisco from Iowa. Although the original intent was that Anesthesia would be a division of the Department of Surgery, Cullen wisely refused, and the Dean agreed that Anesthesia would be established as an independent department. Cullen soon recruited reinforcements, including John Severinghaus, Bill Hamilton, Ted Eger, George Gregory, and Sol Shnider, who quickly put the department on the map as a research and clinical powerhouse.

When Stuart Cullen became Dean of the School of Medicine in 1966, he recruited Bill Hamilton from Iowa to become Chair. Hamilton led the Department through the tumultuous 70’s and 80’s, bringing in key recruits such as Ron Miller, Mike Cahalan, and

Message from the ChairContinuing Our Legacy as a Leader

“This newsletter reflects the bright future of the Department, while honoring the past.”— Michael Gropper, MD, PhD

Mervyn helped us navigate the wrenching loss of Bill Young, one of the most prolific researchers and mentors in the country. When Mervyn began a sabbatical in 2014, I was asked by then Dean Sam Hawgood to serve initially as Acting, and then Interim, Chair.

CAN YOU FIND and name two department chairs in this 1966 photo of the Anesthesia and Perioperative Care Department? Answers on page 12.



1966

This newsletter reflects the bright future of the Department, while honoring the past. Marty Bogetz provides a poignant look at our Ambulatory Surgery Center (ASC), also known as “Martyworld” where many of us fondly remember our time as residents, working in a uniquely high-functioning and patient-centered environment (page 10). We describe our highly successful Early Recovery After Surgery (ERAS) program, which represents the best in modern perioperative care, and is the foundation of the so-called Perioperative Surgical Home. Lee-lynn Chen and Ankit Sarin, Assistant Professor of Clinical Surgery, are revolutionizing the care of surgical patients at our new hospital in Mission Bay. Marc Stuerer gives us an update from San Francisco General Hospital, a world-leader in trauma care and research. You’ll find that trauma care has changed substantially in recent years, with greatly improved patient outcomes. Art Wallace tells us that the San Francisco VA Hospital continues as the flagship hospital in the VA system, and is leading the way in providing cost-effective care for our Veterans.

Research is alive and well in the Department. An innovative residency pathway developed by Manny Pardo and Judith Hellman, the Research Scholars

Pathway, is paying great dividends. Examples of the benefit of early investment in clinician-scientists is demonstrated by the extraordinary success of two of our residents, Liz Whitlock and Catherine Chen, both of whom will join the faculty. As residents, they have had very high-profile publica-tions, showcasing the Department’s strength in clinical research. Jeff Sall is highlighted for his work in what is perhaps the most important, and controversial aspect of current anesthetic practice: does exposure of young children to anesthesia and surgery cause long-lasting learning or cognitive defects. This is a critical question to answer, and will impact any anesthesia provider anesthetizing young children.

A glance at a departmental photo from the 1960’s on the previous page shows an almost entirely white, male, faculty. Building diversity in a department is a journey, and hard work. For example, if one takes the passive approach of relying on the “pipeline” of medical students to fill the residency class, and subsequently the faculty, then the diversity of the residents and faculty will be, at best, the same as the pipeline. By valuing diversity in seeking out the best young trainees and faculty, we can build a workforce that reflects the unique diversity of the Bay Area. A great example is Charlene Swift, who joined the faculty in September,

featured on page 9. We are fortunate to have the support of Renee Navarro, Professor of Anesthesia and Vice Chancellor for Diversity and Outreach, and Dean Talmadge King, as partners in our journey.

I am sobered by the challenge of leading this great Department. We have unprecedented challenges and opportunities. As UCSF Health expands into a large Health Care System with an Accountable Care Organization and widespread affiliations in the Bay Area, the scope of clinical services will continue to grow. It is more important than ever that the faculty, residents, and staff appreciate the importance of our legacy as a leader in academic anesthesiology; I am fully committed to nurturing our clinical, research, and educational missions. I have been fortunate in my own academic career to have visited most of the “leading” anesthesia programs around the country and internationally. That experience has only confirmed in my mind that the UCSF Department of Anesthesia and Perioperative Care is unrivalled. It is the people: the residents, faculty, and staff that convince me that we will continue to be so. As the 5th Chair, I look forward to partnering with those people into a bright future. ■

Michael Gropper, MD, PhD Professor and Chair

“By valuing diversity in seeking out the best young trainees and faculty, we can build a work force that reflects the unique diversity of the Bay Area.” — Michael Gropper, MD, PhD

Messagecontinued from previous page

CAN YOU NAME the faculty member who appears in both the 1966 (page 3) and the 2015 (below) department photos? Answer on page 12.


2015

“By valuing diversity in seeking out the best young trainees and faculty, we can build a work force that reflects the unique diversity of the Bay Area.” — Michael Gropper, MD, PhD

Marc Steurer, MD, DESA

When victims of car or industrial accidents, violent crime and so on arrive at the hospital,

trauma anesthesiologists are responsible for damage control resuscitation – keeping these patients alive until the trauma surgeon can stop the bleeding.

In the past, our first concern tended to be the correction of low blood pressure, so we’d infuse liberal amounts of crystalloids and the blood pressure would rise. The problem was that we were often inducing sites that had stopped bleeding to bleed again. We probably lost a good number of patients we should have saved.

Now we know that until the surgeon gets bleeding under control, we can accept low blood pressures as a human response to surviving trauma and that our primary goal is to quickly weaken the causes of patients bleeding out. In addition, when we do give fluids, we have to use our best clinical judgment as to the right mix of packed red blood cells, fresh frozen plasma, platelets and, at times, medication to achieve resuscitation and support the patient in his or her ability to form clots.

Our primary goal is to get these patients to the OR as quickly as possible – to be pragmatic and not delay care. The patient’s arrival is not the time for inserting another line, doing another test or hooking up another monitor, which is why clinical judgment is so important. We’re often flying without instruments and rely on sound clinical judgment that can prevent us from under- or over-resuscitating and causing circulatory overload, creating an hypercoagulable state with subsequent thrombosis or overdoing red blood cells that can lead to organ failure and infections.

Once the surgeon stops the hemorrhaging, we can slow down and go to more sophisticated medicine: deploy more monitors and specific tests that provide more information on cardiovascular status and better gauge volume, oxygen-carrying capacity and coagulation status so we can adapt accordingly and tailor the resuscitation to the patient’s current need and situation.

It’s no later than this point that we also begin administering anesthetics so the patient is comfortable and, if at all possible, won’t have a lasting memory of the pain he or she experienced while under our care. This is still more art than science and sometimes there’s an understandable hesitancy about giving too many anesthetics too early because of concerns about decreasing cardiac output and blood flow. Yet another of the things we now believe is that proper use of anesthetics could potentially prevent post-traumatic stress disorders related to the patient’s initial resuscitation, which occurs more frequently than one might expect.

Once the patient is in the ICU, we become especially attentive to avoiding complications like multi-organ failure, sepsis, pulmonary embolisms or any form of thrombosis. Avoiding these complications depends on team-based care, which is especially important in the trauma setting. Good communication between surgical and anesthesia teams matters during a given case and, more generally, when we work on things like quality improvement, so that the move-ment among clinical settings and clinical decisions are carefully coordinated from the time the patient arrives.

Our need to facilitate research that supports evidence-based change in

trauma anesthesia and to disseminate best practices is what’s behind the creation a couple of years ago of the Trauma Anesthesiology Society. The society has become an important platform for trauma anesthesiologists around the globe, and for advancing the field in education, research and clinical care.

Trauma remains the most common cause of death for all patients beneath the age of 45. Those who survive often suffer significant physical, emotional and financial burdens. As a central part of the trauma team that includes trauma surgeons, emergency medicine physicians, nursing staff and others, trauma anesthesiologists can play an important role in preventing or mitigating negative outcomes – and ensuring positive ones. ■

Ask the ExpertTrauma care has changed over the last 15 years. What do those changes imply for the unique challenges trauma anesthesiologists face?

“As a central part of the trauma team... trauma anesthesiologists can play an important role in preventing or mitigating negative outcomes – and ensuring positive ones.” — Marc Steurer, MD, DESA

Marc Steurer, MD, DESA, is director of Trauma Anesthesiology at San Francisco General Hospital and president of the Trauma Anesthesiology Society.


http://www.tashq.org

http://www.tashq.org

Education

Innovative Residency Successfully Fosters the Careers of Emerging Clinician-Researchers

The UCSF Department of Anesthesia and Perioperative Care created its Research

Scholars Track with the goal of helping promising residents jumpstart their careers as clinician-researchers. Given the productivity of the initial cohorts – including 2015 publications in the New England Journal of Medicine and British Medical Journal – it’s hard to view the program as anything less than an unqualified success.

“By creating flexible, protected time for research and making sure residents are paired with mentors and projects that are exciting to them and meet their career goals, we help young researchers get to the point where they’re publishing and/or achieving significant findings by the end of their residency,” says Judith Hellman, MD, who directs the research track.

Hellman – who recently won the 2015 International Anesthesia Research Society’s Frontiers in Anesthesia Research Award – emphasizes that the department has intentionally selected individuals for this track who can excel in both clinical and research arenas. “Clinical competence helps them to be successful research-wise, and gives them credibility within the department and discipline,” she says.

Vast Opportunities Support Broad InterestsShe also notes that this year’s prestigious, lead author publications by residents Catherine Chen, MD, MPH (New England Journal of Medicine) and Elizabeth Whitlock, MD, MSc (British Medical Journal) exemplify how the department’s support and flexibility – the department is open to a broad range

of basic, clinical, translational and policy research – can lead to early success.

Chen – who came to medicine after spending time as an investment-banking analyst and who earned her MPH during medical school – arrived with a keen interest in health services research. Drawing on UCSF’s vast resources, she found a mentor in R. Adams Dudley, MD, MBA, one of the country’s leading health services researchers.

The two zeroed in on the suspected overuse of preoperative testing for minor surgeries. They conducted a study that found physicians were not following evidence-based guidelines for preoperative testing in cataract surgery – a procedure that 1.7 million Medicare beneficiaries undergo each year. The

Catherine Chen, MD, MPH


The RESEARCH SCHOLARS

TRACK is one of two innovative

residency pathways at the

UCSF Department of

Anesthesia and Perioperative

Care. Future issues will

explore the CRITICAL CARE

SCHOLARS TRACK.


guidelines – on which the major professional societies have agreed for more than a decade – recommend that for most cataract surgeries, routine preoperative testing is unnecessary.

“It’s an outpatient procedure that typically takes less than 20 minutes. A large, randomized, controlled trial found no real differences in cancella-tions, complications or negative outcomes when those tests were done” says Chen. “But many physicians still routinely order testing.”

In fact, after reviewing Medicare data from about 440,000 patients undergoing cataract surgery in 2011, Chen found that there had been virtually no change in the number of tests physicians ordered or the percentage of patients tested compared to 20 years ago.

“The take-home message is that it’s not about how sick or how old patients are, but the practice patterns of some physicians result in the overuse of these unnecessary tests,” says Chen.

Whitlock also did data analysis, but in her case, she used hospital billing and administrative data for 1.6 million adult patients to understand the relationship between perioperative transfusion and perioperative stroke and heart attack.

“My research interests are in re-examining practices we take for granted, but which have plausible connections to adverse perioperative reactions,” says Whitlock. “Perioperative transfusion is extremely common and is generally assumed to be safe, but it is a modifiable risk factor and our study found that even one unit of packed red blood cells is associated with increased odds of perioperative ischemic stroke and/or heart attack.”

“Clinical competence helps [young researchers] to be successful research-wise, and gives them credibility within the department and discipline.”— Judith Hellman, MD

She cautions that there are many limitations in database studies – most notably that they cannot establish causality. Yet she believes enough is known about perioperative transfusion that prior to elective surgeries, primary care physicians and anesthesiologists should at least consider intervening with patients who have anemia – a common, easily modifiable preoperative condition.

“We’ve gotten kind of cavalier about transfusion, but if my parents were having elective hip replacement and were anemic, I would want the team to correct for it preoperatively with low-risk interventions,” says Whitlock.

The Difference the Track MakesHellman is proud of accomplishments like those of Chen and Whitlock, but says, “We don’t expect everyone to graduate with a first author papers in NEJM or BMJ. The other research track residents are also thriving.”

She says there are many examples in other research areas, mentioning the accomplishments of residents Paul Riegelhaupt, MD, PhD, who is doing basic science work on potassium channels and that of Michael Bokoch, MD, PhD who is studying the role of platelets in liver transplants. All benefit from the track’s flexible support for their research time.

“What’s unique here is how integrated the research and clinical times are,” says Chen. “It’s not just one year. While I was waiting for CMS to approve my application for Medicare data, I was able to complete several required clinical rotations.”

“We’ve built in that flexibility, precisely because waiting time in research is true not only of things like Medicare data but also in other areas like human studies or animal protocols,” says Hellman.

Whitlock also appreciates the department’s support, which helped her take critical coursework and forge connections she needed outside of UCSF to pursue her work. She says, “[The department’s support] allows me to maintain a record of research productivity during residency and launches me into a better position to apply for funding.” ■

Above: Judith Hellman, MD At left: Elizabeth Whitlock, MD, MSc, on a medical mission with Operation Rainbow in Zihuatanejo, Mexico, in March 2015 (photo by Research Scholar Michael Bokoch, MD, PhD)

Educationcontinued from previous page


Research Seeking Safer Ways to Anesthetize Newborns and Young Children

More than a million children under age five are anesthetized in the United States every year.

While many of the procedures are medically necessary, various studies have begun to find associations between learning/cognitive deficits and anesthetic exposure.

Establishing whether there is a causal link – and identifying the mechanism a nd risk factors for such deficits – is what drives the research of Jeffrey Sall, MD, PhD, of the UCSF Department of Anesthesia and Perioperative Care. His lab is funded primarily by an NIH RO1 grant and Smart Tots, a multi-year collaborative effort of the International Anesthesia Research Society and the US Food and Drug Administration with the goal of increasing the safety of anesthetic drugs for infants and children.

Exploring Gender-Related DifferencesSall investigates concerns about the effects of anesthesia – both volatile anesthetics and IV agents – on young brains from multiple angles. His primary focus at present is to examine why certain cognitive deficits associated with anesthesia exposure – such as association and recognition memory – affect males more than females.

Having seen these differences buried in the data of large retrospective human

studies, rodent studies and the initial stages of a prospective human trial, Sall is now principal investigator on an NIH RO1 grant for rodent studies that he hopes will identify the specific sex-related factors that account for the learning differences. His hypothesis is that a brief developmental difference in chloride channel expression may lead to increased male vulnerability.

“We think the anesthetics affect neuron connections and help determine which survive and which don’t during this particularly vulnerable period in

development,” says Sall. “In adults, the circuits are already connected but in development, they’re in a rapid state of change and are waiting for the right developmental cue. It may be that anesthetics tip the balance.”

That tipping point, he says, may be the root of meaningful learning deficits that have both individual and societal costs. That’s why Sall believes it is especially important to expand the knowledge base on this topic, so among other things, physicians and families can make more informed decisions about how and when to perform a procedure that requires anesthesia. More knowledge can also drive investigations into new types of anesthetics with fewer side effects for young brains.

Already, he says, his research and that of others argues that physicians and families should at least more vigorously consider alternatives, especially whether a proposed procedure can wait until the child is older and more advanced developmentally.

“We don’t yet have a clearly defined window for which age ranges are more or less vulnerable or in what time frame anesthesia becomes unsafe,” he says. “But so far the data suggest that shorter is better and later is better.” ■

“We think the anesthetics affect neuron connections and help determine which survive and which don’t during this particularly vulnerable period in development.” — Jeffrey Sall, MD, PhD

Jeffrey Sall, MD, PhD


Staff Highlight Finding a New Home at UCSF and in the Bay Area

Faculty Highlight Swift Brings Her Talent and Passion

In 2014, the winter in Chicago was particularly cold. Melissa Patrick was working as a program administrator for the anesthesia program at Advocate Illinois Masonic Medical Center – right by Chicago’s Wrigley Field says the

avid sports fan – when she began googling graduate medical education positions located in warmer climates.

“This just popped up and I threw my hat in the ring,” she smiles. “This” is the position of assistant director of the department’s Education Program.

By January 2015, Patrick had won the job and she and her husband – who works in finance for a solar company – had moved across the country. They are happy to be in the department and in the Bay Area, says the Midwest native, who grew up in Prairie Du Chien, Wisconsin.

In the department, Patrick supervises all of the coordinators for the clerkship, residency and fellowship programs, her primary role being to ensure the department is in compliance with all graduate medical education (GME) and state regulations.

“The work changes every day, depending on the season,” she says. After closing the fiscal year, completing new hires and creating a new budget, Patrick was looking to ease into the residency interview season. “I’m letting coordinators know I’m available to help with things like appointment packets, access badges – just making sure everything they need is covered.”

Medical Education a Career Shift

Patrick began her working life expecting to be a high school teacher, but after one semester as a long-term sub decided that being in front of a classroom was not for her. Still, she wanted to remain involved in education and so found a job as an administrative assistant in the surgery department at the University of Wisconsin, where she worked her way up the job ladder while earning her MBA at the school.

Though she’s enjoying the move to San Francisco – she lives close to the hospital – Patrick does confess, “I miss Midwest summers…you wait nine months for three months of amazing summer and fun. And I miss football season – this waking up early for football games will take me a bit to get used to. We’re a Bears and Packers house – Big Ten football and Cubs fans too. We are learning to love the Warriors, though.”

She also enjoys exploring her adopted state, having spent time in places that include Los Angeles, Sonoma, Half Moon Bay and Marin County. “Every month we try to take two weekends to see things outside of the city,” she says. “We hike a little bit, learn a little more about wine and try restaurants – we had people write down favorite restaurants in the city so we’d know where to go, but it’s hard to pick a favorite. We take all of our visitors to Sam’s Chowder House in Half Moon Bay.” ■

When Charlene Blake Swift, MD, PhD, joined the UCSF Department of Anesthesia and

Perioperative Care in September 2015, she brought with her an impressive list of accomplishments for a career that is only in its early stages.

After graduating summa cum laude from Fisk University, Swift earned her MD and a PhD in Genetics and Genomics from Duke University. She trained in anesthesiology and recently completed her fellowship in cardiothoracic anesthesiology at Washington University in St. Louis.

Throughout her clinical training, Swift has combined a deep interest in technology with a passionate commitment

to clinical education and diversity development – all strong interests of the UCSF Department of Anesthesia, says Department Chair Michael Gropper, MD, PhD. Swift is an active participant in the Society for Technology in Anesthesia, and

her successful recruitment to UCSF brings with it a faculty recruitment grant from the Dean’s Diversity fund that will support both her training as a clinical educator and her interest in integrating technology into anesthesia education and practice.

“A combination of things drew me to UCSF,” she says. “The strong department history, the Bay Area as a technology hub, leadership that is open to bringing technology into both clinical practice and education and the opportunity to be involved with diversity efforts.”

Swift and her husband – an entrepreneur who owns and operates a business focused on distributing promo-tional products and logoed apparel for corporations – arrived in the Bay Area in August. In addition to her work at UCSF, she is looking forward to running on trails in the Marin headlands, spending time in Napa and Sonoma and resuming an interest in ballroom dancing. ■

Charlene Blake Swift, MD, PhD

Melissa Patrick, MBA


Around 1984, when outpatient surgery was in its adolescence, UCSF decided to design and

develop a unit specifically for its growing population of surgical outpatients. Perioperative leadership appreciated that the main operating room’s physical layout, workflow and administrative structure hindered efficient, cost-effective and patient-centered care. The unit would be on hospital grounds, but physically separate from the main operating rooms. Neal Cohen and Anthony Wagner, a hospital admini-strator, led the redesign of 12,000 square feet on the plaza level of the Ambulatory Care Center.

I was stationed at San Francisco General Hospital – where I had been tasked with developing an outpatient unit – when then Department Chair Ron Miller asked if I would be interested in applying to become medical director of the new unit.

One of the unit’s founding principles was to appreciate and continually earn the trust of patients and families who chose to have their care in the ASC. Our focus on service reflected an under-standing that this care was delivered through a multitude of surgeons, ophthalmologists, pediatricians, internists, dermatologists, hematologists,

oncologists, psychiatrists, pathologists and dentists. When someone needed care we tried not to hide behind the end of a shift, the end of block time or the threat of being over budget.

Preoperative, intraoperative and postoperative staff all worked under a single administrative structure. Post-Anesthesia Care Unit nurses became competent in conscious sedation and operating room (OR) nurses rotated through the preoperative process. I remain extremely proud that practices put into place by the nursing staff, support staff and anesthesiologists served and continue to serve as a model for all UCSF perioperative venues. We put the fun into dysfunctional!

Many AccomplishmentsI am also proud that we pushed the limits of outpatient surgery by caring for patients that most other outpatient units wanted nothing to do with, such as the mentally handicapped, extremes of age and the seriously infirm. Our safety record was also a source of pride in that our unplanned admission rate was better than the benchmarks for the day and there were no deaths in the unit throughout its entire existence. We were unusually blessed to have long-term relationships with some of the most

vulnerable patients and we strove to make such patients and families feel that our home was their home.

The ASC was also the first clinical site in the United States to routinely use the Laryngeal Mask Airway (LMA) and was one of the early adopters of propofol. UCSF programs that originated in the ASC include the in-vitro fertilization program, sports medicine, laser therapy in dermatology, electroretinography and auditory evoked potentials for children, dentistry for the mentally handicapped and outpatient electroconvulsive therapy (ECT).

Education of anesthesia residents focused on the care of the surgical outpatient and included:

■■ Use of the LMA family of products

■■ Management of ECT

■■ Care of the pediatric patient, including parental presence for induction and regional anesthesia

■■ Monitored anesthesia care

■■ Care of the mentally handicapped

■■ Regional anesthesia for sports medicine

■■ Efficiency

■■ Working in small groups with professionalism and good communication

Medical students were present in the Surgery Center from the beginning, as were learners from UCSF School of Dentistry.

I must acknowledge the expertise and contributions of the over 250 individuals who served as ASC staff. Whether one greeted patients to make them feel at home, helped ready them for surgery, cared for them in the OR, applied one’s skills to keep them safe and comfortable throughout, helped them recover, escorted them to the car, kept the instruments sterile and organized, kept the place clean, managed supplies and implants or provided the “manpower” to keep the place going – you played a

Farewell — by Martin Bogetz, MDAmbulatory Surgery Center ClosesJune 24, 2015 marked the last clinical day of the UCSF Ambulatory Surgery Center (ASC). The center cared for approximately 125,000 patients during almost 28 years of operation.


Martin Bogetz, MD, at the UCSF Ambulatory Surgery Center


vital role. I also acknowledge the many surgeons who earned our respect and admiration for their skills and, dare I say, friendship. I also acknowledge the scores of anesthesia faculty, CRNAs, residents and students who not only provided exemplary care, but also contributed to the education of scores of learners.

Anesthesiologists who played a prominent role in the ASC include Fred Orkin, Barbara Gold, Gregg Garbin, Walter Way, Jeff Swisher and Laura Siedman. For almost a decade Laura provided leadership, professionalism and unrivaled expertise along with a dedication to the care of the thousands of children who came through the ASC. She served as Medical Director for its last three years.

I also must acknowledge Ron Miller for his vision and support of the Surgery Center and me for over 22 years. Michael LeBoff must be recognized for the many years he literally stood next to the residents and faculty during induction and single-handedly managed anesthesia supplies and equipment – his work-room was second to none. A number of nurses also figure prominently in the success of the Surgery Center – Betty Yalich, Deborah Frase, Catherine Win and George Gomez. George defined the ASC as its Patient Care Manager for many years. The example he set in professionalism, ethics and dedication to the unit and the institution remain unrivaled to this day.

The ASC represents virtually my entire academic and clinical life at UCSF. I think about the tens of thousands of patients I had the privilege to care for, the poignancy of illness and the grace that patients and families demonstrated in dealing with, at times, unspeakable adversity. I am indebted to all the professionals that gave the ASC its deserved reputation. Most cherished are the learners. My legacy is the small role I played in helping medical students and residents appreciate our noble specialty. ■

Please send any comments or a description of a Surgery Center memory to [email protected].

VA Update Using Data to Create Value-Based Care

At the San Francisco Veterans Affairs Medical Center, anesthesiologists are effectively using data gleaned from a nationwide system of electronic medical records, as well as anesthesia and intensive care unit record-keeping

systems to improve the access and quality of the care they deliver, says Arthur Wallace, MD, PhD, chief of the Anesthesia Service and vice chair of the UCSF Department of Anesthesia and Perioperative Care.

Wallace has helped create a national anesthesia quality improvement program – VA-AnesQIP – to study all of the patients who receive anesthesia care in the VA, for any surgical and non-surgical procedure.

Improving Quality and EfficiencyTo improve efficiency and access, the program analyzes nationwide data to track things like utilization, on-time starts, and turnover times. “By finding the places we’ve been inefficient, we’ve been able to improve throughput in the San Francisco VA OR by almost 30 percent over the last ten years without spending extra money,” says Wallace. “We’ve realized, for example, that we tend to have time available at the end of day or on certain days of the week, so we’ve encouraged people to change scheduling and that’s allowed us to cut wait lists and improve access.”

Wallace says the program has also used the data to identify modifiable risk factors that affect mortality and to encourage providers to change practices to those that can save lives.

“These are simple things: for example, allowing the heart rate to be over 120 for more than five minutes quadruples the risk of dying; being aware that anti-ischemic drugs don’t work if the patient is hypotensive,” says Wallace. “We can now provide a report that shows the incidence of modifiable risk factors and then help facilities reduce risk. Practitioners want to do a good job, but just didn’t know they were an outlier on these risk factors and didn’t know how to fix the problem.”

He says the VA_AnesQIP program exemplifies the value of being at the VA where QI programs run across large populations and the primary goal is to provide the best care possible. “In a new era of computer power, we can easily do a study with ten years worth of data and three or four million people,” he says. “That’s when you can really identify and fix the problems.” ■

“By finding the places we’ve been inefficient, we’ve been able to improve throughput in the San Francisco VA OR by almost 30 percent over the last ten years without spending extra money.” — Arthur Wallace, MD, PhD

Farewellcontinued from previous page


John Markley, MD, PhD Health Sciences Assistant Clinical ProfessorJoined Faculty July 2015ADVANCED DEGREEPhD, Immunology, Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD/PhD ProgramMEDICAL SCHOOLWeill Medical College of Cornell UniversityINTERNSHIPAnesthesiology, UCSFRESIDENCYAnesthesiology, UCSFFELLOWSHIPOB Anesthesiology, Brigham and Women’s Hospital

Bradley Randel, MD Health Sciences Associate Clinical ProfessorJoined Faculty July 2015MEDICAL SCHOOLUC DavisRESIDENCYAnesthesiology, Massachusetts General HospitalFELLOWSHIPPediatric AnesthesiologyChildren’s National Medical CenterPREVIOUS EMPLOYMENTAssistant Clinical Professor, Anesthesiology, UC Davis

Candace Shavit, MD Health Sciences Clinical InstructorJoined Faculty September 2015MEDICAL SCHOOLSackler School of MedicineINTERNSHIPAnesthesiology, UCSFRESIDENCYAnesthesiology, UCSF

Devon Smith, MD Health Sciences Assistant Clinical ProfessorJoined Faculty July 2015MEDICAL SCHOOLUniversity of MichiganINTERNSHIPAnesthesiology, UCSFRESIDENCYAnesthesiology, UCSFFELLOWSHIPOB Anesthesiology, UCSF

Career FacultyCatherine Chen, MD, MPH Health Sciences Clinical Instructor, T32 Postdoctoral TraineeJoined Faculty August 2015MEDICAL SCHOOLJohns Hopkins School of MedicineINTERNSHIPAnesthesiology, UCSFRESIDENCYAnesthesiology, UCSF

Brian Gilliss, MD Health Sciences Assistant Clinical ProfessorJoined Faculty August 2015MEDICAL SCHOOLUCSFINTERNSHIPAnesthesiology, UCSFRESIDENCYAnesthesiology, UCSFFELLOWSHIPPediatric Anesthesiology, UCSF

Vanessa Henke, MD Health Sciences Assistant Clinical ProfessorJoined Faculty June 2015MEDICAL SCHOOLHarvard Medical SchoolINTERNSHIPInternal Medicine, Yale-New Haven HospitalRESIDENCYAnesthesiology, Massachusetts General HospitalFELLOWSHIPSIntensive Care Medicine, Stanford University School of MedicineCardiothoracic Anesthesiology, UCLAPREVIOUS EMPLOYMENTAssistant Professor of Anesthesiology, Weill Cornell Medical College

Robyn Hilles, MD Health Sciences Clinical Instructor, Per DiemJoined Faculty July 2015MEDICAL SCHOOLColumbia University College of Physicians and SurgeonsINTERNSHIPAnesthesiology, UCSFRESIDENCYAnesthesiology, UCSF

Lindsey Huddleston, MD Health Sciences Assistant Clinical ProfessorJoined Faculty July 2015MEDICAL SCHOOLUCSDINTERNSHIPAnesthesiology, UCSFRESIDENCYAnesthesiology, UCSFFELLOWSHIPCritical Care Medicine, UCSF

Michael Lipnick, MD Assistant Professor of Clinical AnesthesiaJoined Faculty October 2015MEDICAL SCHOOLUCSFINTERNSHIPInternal Medicine, Brigham and Women’s HospitalRESIDENCYAnesthesiology, UCSFFELLOWSHIPAnesthesia Critical Care Medicine, UCSF

Solmaz Poorsattar Manuel, MDHealth Sciences Clinical Instructor Joined Faculty September 2015MEDICAL SCHOOLUCSFINTERNSHIPInternal MedicineKaiser Permanente San FranciscoRESIDENCYAnesthesiologyMassachusetts General Hospital, Harvard School of Medicine

New FacultyANSWERS: Find and name two department chairs in this 1966 photo (page 3) of the Anesthesia and Perioperative Care Department: 4th row, left: Ronald Miller 1st row, 4th from left: Stuart Cullen

Name the faculty member who appears in both the 1966 (page 3) and 2015 (page 4) Department photos: Ted Eger


Charlene Swift, MD, PHD Health Sciences Assistant Clinical ProfessorJoined Faculty August 2015ADVANCED DEGREEPhD, Genetic and Genomics, Duke UniversityMEDICAL SCHOOLDuke UniversityRESIDENCYAnesthesiology, Washington University FELLOWSHIPCardiothoracic Anesthesiology, Washington University

Jessica Tashjian, MD Health Sciences Assistant Clinical ProfessorJoined Faculty July 2015MEDICAL SCHOOLDuke UniversityRESIDENCYAnesthesiology, University of Virginia Health SystemFELLOWSHIPCardiothoracic Anesthesiology, UCSF

Arthur Wood, MD Health Sciences Assistant Clinical ProfessorJoined Faculty August 2015MEDICAL SCHOOLHarvard Medical SchoolINTERNSHIPInternal Medicine, Stanford UniversityRESIDENCYAnesthesiology, Brigham and Women’s HospitalFELLOWSHIPSPain Management, Stanford UniversityClinical Excellence Research, Stanford University

Visiting FacultyBenn Lancman, MBBS, MHumFac, FANZCAVisiting Clinical InstructorADVANCED DEGREEMaster of Human Factors and Safety Management Systems, University of South AustraliaMEDICAL SCHOOLMonash UniversityINTERNSHIPBankstown Hospital, NSWRESIDENCYRoyal Prince Alfred Hospital, Australian & New Zealand College of AnaesthetistsFELLOWSHIPAnaesthetic Fellow, Melbourne Health

Andrew Bishara

Charles (Phil) Aguilar

Robert Caughey

Vikram Fielding-Singh

Scott Grubb

Jessica Hartnett

K. Elliot Higgins

Jason Lang

Esther Lee

Ana Valdez

Thanh-Giang (Tina) Vu

Angela Wight

Michael Wu

Jane Yu

Tina Yu

Michael Lubrano

Revati Nafday

Anne Park

Alec Peniche

Marci Pepper

Alison Schultz

Sonny Sabhlok

Lisa Sun

New Residents CLASS OF 2018


UCSF Awarded NIH Pain Consortium Centers of Excellence in Pain Education

The NIH Pain Consortium has selected UCSF as a designated Center of

Excellence in Pain Education (CoEPE). Under the direction of Mark Schumacher, Chief, Division of Pain Medicine in the Department of Anesthesia and Perioperative Care, the UCSF CoEPE will join other centers to serve as hubs for the develop-ment, assessment, and distribution of pain management curriculum resources. The UCSF CoEPE will draw together a diverse faculty from our medical, dental, nursing, and pharmacy schools, to enhance and improve the teaching of health care professionals about pain and its treatment. Further, the CoEPEs plan to assess the success of their pain teaching programs and disseminate their results to the general health care education field. ■

Lead UCSF CoEPE Faculty:

Mark Schumacher, PhD, MDPrincipal Investigator

Mark Rollins, MD, PhDSchool of Medicine

Lori Reisner, PharmDSchool of Pharmacy

Christine Miaskowski, RN, PhD, FAANSchool of Nursing

Jon Levine, MD, PhDSchool of Dentistry

Scott Steiger, MDInterprofessional

Faculty Honors, Awards and Appointments

Philip Bickler, MD, PhDEXTRAMURAL APPOINTMENT

Elected Member, California Academy of Sciences, 2015

Neal Cohen, MD, MPH, MSEXTRAMURAL APPOINTMENT

Chair, Board of Directors, El Camino Hospital, Mountain View and Los Gatos, California

Anne Donovan, MDCAMPUS HONOR

Excellence in Teaching Award, UCSF Haile T. Debas Academy of Medical Educators, 2015

Michael Gropper, MD, PhDCAMPUS APPOINTMENT

Chair, UCSF Department of Anesthesia and Perioperative Care, 2015

Matthew Haight, DOCAMPUS APPOINTMENT

Member, UCSF School of Medicine Faculty Council, 2014–2017

Monica Harbell, MDCAMPUS HONOR


Judith Hellman, MD, PhDEXTRAMURAL AWARD

Frontiers in Anesthesia Research Award, International Anesthesia Research Society (IARS), 2015

Michael Lipnick, MDEXTRAMURAL APPOINTMENT

Dive Medical Officer, California Academy of Sciences, 2015

Ronald Miller, MDEXTRAMURAL HONOR

Miller’s Anesthesia, 8th Edition, 2015

Ramana Naidu, MDCAMPUS APPOINTMENT

Director, Acute Pain Services, UCSF Medical Center, 2015

J. Renee Navarro, MD, PharmDEXTRAMURAL HONOR

Extraordinary Women in STEM (Science, Technology, Engineering, and Math) Award, 2015

Hung Nguyen, MDCAMPUS HONOR

Medical Humanism Award, UCSF Department of Anesthesia and Perioperative Care, 2015

Oliver Radke, MD, PhDEXTRAMURAL APPOINTMENT

Chair, Department of Anesthesia and Intensive Care Medicine, Bremerhaven Trauma Hospital, Bremerhaven, Germany

Mark Rollins, MD, PhDCAMPUS HONOR

William K. Hamilton Award for Excellence in Teaching, 2015

Jeffrey Sall, MD, PhDEXTRAMURAL APPOINTMENT

Elected Member, Association of University Anesthesiologists

Mark Schumacher, PhD, MDEXTRAMURAL APPOINTMENT

Pain Task Force Member, California Society of Anesthesiologists, 2015

Ahmed Shalabi, MDCAMPUS HONOR

Ronald D. Miller Award for Excellence in Resident Mentorship, 2015

Gail Shibata, MDCAMPUS HONOR


John Turnbull, MDCAMPUS HONOR


Stephen Weston, MDCAMPUS APPOINTMENT

Medical Director, Operating Room Support Services / Anesthesia Workroom, UCSF Medical Center, 2015

Trainee Honors, Awards, and Appointments

Michael Bokoch, MD, PhDCAMPUS HONOR

Jeffrey A. Katz Award for Work Ethic and Professionalism During Residency, 2015

Grant Sanders, MDCAMPUS HONOR

Stuart C. Cullen Award for Excellence During Residency, 2015

Elizabeth Whitlock, MD, MScCAMPUS HONOR

Mark A. Rosen Award for Scholarship During Residency, 2015

Honors & Awards


Peer Reviewed Publications



Calello DP, Liu KD, Wiegand TJ, Roberts DM, Lavergne V, Gosselin S, Hoffman RS, Nolin TD, Ghannoum M; Extracorporeal Treatments in Poisoning Workgroup. Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup. Crit Care Med. 2015 Aug;43(8):1716-30.

Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB; NIH NHLBI ARDS Network. Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies. Chest. 2015 Jun;147(6):1539-48.

Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB. Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Crit Care Med. 2015 Sep;43(9):1790-7.

Caruana E, Chevret S, Resche-Rigon M, Pirracchio R. A new weighted balance measure helped to select the variables to be included in a propensity score model. J Clin Epidemiol. 2015 May 1.

Caruana E, Duchateau FX, Cornaglia C, Devaud ML, Pirracchio R. Tracheal intubation related complications in the prehospital setting. Emerg Med J. 2015 Jan 20.

Cerdá J, Liu KD, Cruz DN, Jaber BL, Koyner JL, Heung M, Okusa MD, Faubel S; AKI Advisory Group of the American Society of Nephrology. Promoting Kidney Function Recovery in Patients with AKI Requiring RRT. Clin J Am Soc Nephrol. 2015 Jul 2.

Chen CL, Lin GA, Bardach NS, Clay TH, Boscardin WJ, Gelb AW, Maze M, Gropper MA, Dudley RA. Preoperative medical testing in Medicare patients undergoing cataract surgery. N Engl J Med. 2015 Apr 16;372(16):1530-8.

Chen CL, Gelb AW, Dudley RA. Preoperative Testing in Patients Undergoing Cataract Surgery. N Engl J Med. 2015 Jul 16;373(3):285-6.

Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015 Apr 1;191(7):758-66.

Cooke DL, Bauer D, Sun Z, Stillson C, Nelson J, Barry D, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Su H, Saeed MM. Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model. Interv Neuroradiol. 2015 Feb;21(1):120-8.

Johanning J, Katlic M, Kempton J, Kennedy M, Kimchi E, Ko C, Leung J, Mattison M, Mohanty S, Nana A, Needham D, Neufeld K, Richter H, Radcliff S, Weston C, Patil S, Rocco G, Yue J, Aiello SE, Drootin M, Ickowicz E, Samuel MJ.) American Geriatrics Society abstracted clinical practice guideline for postoperative delirium in older adults. J Am Geriatr Soc. 2015 Jan;63(1):142-50.

Anderson WG, Cimino JW, Ernecoff NC, Ungar A, Shotsberger KJ, Pollice LA, Buddadhumaruk P, Carson SS, Curtis JR, Hough CL, Lo B, Matthay MA, Peterson MW, Steingrub JS, White DB. A multicenter study of key stakeholders’ perspectives on communicating with surrogates about prognosis in intensive care units. Ann Am Thorac Soc. 2015 Feb;12(2):142-52.

Barrett JS, Hirankarn S, Holford N, Hammer GB, Drover DR, Cohane CA, Anderson B, Dombrowski E, Reece T, Zajicek A, Schulman SR. A hemodynamic model to guide blood pressure control during deliberate hypotension with sodium nitroprusside in children. Front Pharmacol. 2015 Jul 28;6:151.

Barry AE, Chaney MA, London MJ. Anesthetic management during cardiopulmonary bypass: a systematic review. Anesth Analg. 2015 Apr;120(4):749-69.

Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med. 2015 May;43(5):1026-35.

Bokoch MP, Behrends M, Neice A, Larson MD. Fentanyl, an agonist at the mu opioid receptor, depresses pupillary unrest. Auton Neurosci. 2015 May;189:68-74.

Borrat X, Valencia JF, Magrans R, Gimenez-Mila M, Mellado R, Sendino O, Perez M, Nunez M, Jospin M, Jensen EW, Troconiz I, Gambus PL. Sedation-analgesia with propofol and remifentanil: concentrations required to avoid gag reflex in upper gastrointestinal endoscopy. Anesth Analg. 2015 Jul;121(1):90-6.

Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL. Transforming Growth Factor- and Interleukin-1 Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem. 2015 Jun 5;290(23):14717-28.

Bráz JM, Wang X, Guan Z, Rubenstein JL, Basbaum AI. Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity. Pain. 2015 Jun;156(6):1084-91.

Niemann CU, Feiner J, Swain S, Bunting S, Friedman M, Crutchfield M, Broglio K, Hirose R, Roberts JP, Malinoski D. Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function. N Engl J Med. 2015 Jul 30;373(5):405-14.

Chen CL, Lin GA, Bardach NS, Clay TH, Boscardin WJ, Gelb AW, Maze M, Gropper MA, Dudley RA. Preoperative medical testing in Medicare patients undergoing cataract surgery. N Engl J Med. 2015 Apr 16;372(16):1530-8.

Chen CL, Gelb AW, Dudley RA. Preoperative Testing in Patients Undergoing Cataract Surgery. N Engl J Med. 2015 Jul 16;373(3):285-6.

Whitlock EL, Kim H, Auerbach AD. Harms associated with single unit perioperative transfusion: retrospective population based analysis. BMJ. 2015 Jun 12;350:h3037.

Abla AA, Nelson J, Kim H, Hess CP, Tihan T, Lawton MT. Silent arteriovenous malformation hemorrhage and the recognition of “unruptured” arteriovenous malformation patients who benefit from surgical intervention. Neurosurgery. 2015 May;76(5):592-600; discussion 600.

Abla AA, Rutledge WC, Seymour ZA, Guo D, Kim H, Gupta N, Sneed PK, Barani IJ, Larson D, McDermott MW, Lawton MT. A treatment paradigm for high-grade brain arteriovenous malformations: volume-staged radiosurgical downgrading followed by microsurgical resection. J Neurosurg. 2015 Feb;122(2):419-32.

Alexander MD, Rebhun JM, Hetts SW, Kim AS, Nelson J, Kim H, Amans MR, Settecase F, Dowd CF, Halbach VV, Higashida RT, Cooke DL. Lesion location, stability, and pretreatment management: factors affecting outcomes of endovascular treatment for vertebrobasilar atherosclerosis. J Neurointerv Surg. 2015 Mar 20.

American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults. (Inouye SK, Robinson T, Blaum C, Busby-Whitehead J, Boustani M, Chalian A, Deiner S, Fick D, Hutchison L, Johanning J, Katlic M, Kempton J, Kennedy M, Kimchi E, Ko C, Leung J, Mattison M, Mohanty S, Nana A, Needham D, Neufeld K, Richter H.) Postoperative delirium in older adults: best practice statement from the American Geriatrics Society. J Am Coll Surg. 2015 Feb;220(2):136-48.e1.

American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults. (Inouye SK, Robinson T, Blaum C, Busby-Whitehead J, Boustani M, Chalian A, Deiner S, Fick D, Hutchison L,


Publicationscontinued from previous page


Cui WW, Ramsay JG. Pharmacologic approaches to weaning from cardiopulmonary bypass and extracorporeal membrane oxygenation. Best Pract Res Clin Anaesthesiol. 2015 Jun;29(2):257-70.

Curley MA, Wypij D, Watson RS, Grant MJ, Asaro LA, Cheifetz IM, Dodson BL, Franck LS, Gedeit RG, Angus DC, Matthay MA; RESTORE Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators Network. Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. JAMA. 2015 Jan 27;313(4):379-89.

Curley MA, Wypij D, Matthay MA; RESTORE Study Investigators. Sedation protocol for critically ill pediatric patients--reply. JAMA. 2015 May 5;313(17):1754-5.

Daniels KM, Yu EY, Maine RG, Corlew S, Bing S, Hoffman WY, Gregory GA. Palatal fistula risk after primary palatoplasty: a retrospective comparison of humanitarian operations and tertiary hospitals. Lancet. 2015 Apr 27;385 Suppl 2:S37.

De Pinto M, Naidu RK. Peripheral and Neuraxial Chemical Neurolysis for the Management of Intractable Lower Extremity Pain in a Patient with Terminal Cancer. Pain Physician. 2015 Jul-Aug;18(4):E651-6.

DePianto DJ, Chandriani S, Abbas AR, Jia G, N’Diaye EN, Caplazi P, Kauder SE, Biswas S, Karnik SK, Ha C, Modrusan Z, Matthay MA, Kukreja J, Collard HR, Egen JG, Wolters PJ, Arron JR. Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax. 2015 Jan;70(1):48-56.

Drover DR, Hammer GB, Barrett JS, Cohane CA, Reece T, Zajicek A, Schulman SR. Evaluation of sodium nitroprusside for controlled hypotension in children during surgery. Front Pharmacol. 2015 Jul 6;6:136.

Elobu AE, Kintu A, Galukande M, Kaggwa S, Mijjumbi C, Tindimwebwa J, Roche A, Dubowitz G, Ozgediz D, Lipnick M. Research in surgery and anesthesia: Challenges for post-graduate trainees in Uganda. Educ Health (Abingdon). 2015 Jan-Apr;28(1):11-5.

Fan Y, Geren IN, Dong J, Lou J, Wen W, Conrad F, Smith TJ, Smith LA, Ho M, Pires-Alves M, Wilson BA, Marks JD. Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity. PLoS One. 2015 Aug 14;10(8):e0135306.

Fan Y, Dong J, Lou J, Wen W, Conrad F, Geren IN, Garcia-Rodriguez C, Smith TJ, Smith LA, Ho M, Pires-Alves M, Wilson BA, Marks JD. Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B. Toxins (Basel). 2015 Aug 26;7(9):3405-3423.

Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay MA. Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4. J Immunol. 2015 Aug 1;195(3):875-81.

Feiner JR, Gropper MA, Toy P, Lieberman J, Twiford J, Weiskopf RB. A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery. Anesthesiology. 2015 May 6.

Feng X, Maze M, Koch LG, Britton SL, Hellman J. Exaggerated Acute Lung Injury and Impaired Antibacterial Defenses During Staphylococcus aureus Infection in Rats with the Metabolic Syndrome. PLoS One. 2015 May 15;10(5):e0126906.

Fitzgerald A, Johnson M, Hirsch J, Rich MA, Fidler R. Inconsistent shock advisories for mono-morphic VT and Torsade de Pointes — A prospective experimental study on AEDs and defibrillators. Resuscitation. 2015 Jul;92:137-40.

Foster MC, Coresh J, Bonventre JV, Sabbisetti VS, Waikar SS, Mifflin TE, Nelson RG, Grams M, Feldman HI, Vasan RS, Kimmel PL, Hsu CY, Liu KD; CKD Biomarkers Consortium. Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study. Clin J Am Soc Nephrol. 2015 Sep 8.

Freeman CM, Crudgington S, Stolberg VR, Brown JP, Sonstein J, Alexis NE, Doerschuk CM, Basta PV, Carretta EE, Couper DJ, Hastie AT, Kaner RJ, O’Neal WK, Paine R 3rd, Rennard SI, Shimbo D, Woodruff PG, Zeidler M, Curtis JL. Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). J Transl Med. 2015 Jan 27;13:19.

Fufaa GD, Weil EJ, Nelson RG, Hanson RL, Bonventre JV, Sabbisetti V, Waikar SS, Mifflin TE, Zhang X, Xie D, Hsu CY, Feldman HI, Coresh J, Vasan RS, Kimmel PL, Liu KD; Chronic Kidney Disease Biomarkers Consortium Investigators. Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus. Diabetologia. 2015 Jan;58(1):188-98.

Gambús PL, Trocóniz IF, Feng X, Gimenez-Milá M, Mellado R, Degos V, Vacas S, Maze M. Relation between acute and long-term cognitive decline after surgery: Influence of metabolic syndrome. Brain Behav Immun. 2015 Jul 8.

Gambús PL, Trocóniz IF. Pharmacokinetic-pharmacodynamic modelling in anaesthesia. Br J Clin Pharmacol. 2015 Jan;79(1):72-84.

Ghannoum M, Wiegand TJ, Liu KD, Calello DP, Godin M, Lavergne V, Gosselin S, Nolin TD, Hoffman RS; EXTRIP workgroup. Extracorporeal treatment for theophylline poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2015 May;53(4):215-29.

Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ. Outcomes for extremely premature infants. Anesth Analg. 2015 Jun;120(6):1337-51.

Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR 3rd, Morris AH; National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome. Crit Care Med. 2015 Feb;43(2):288-95.

Hammer GB, Lewandowski A, Drover DR, Rosen DA, Cohane C, Anand R, Mitchell J, Reece T, Schulman SR. Safety and efficacy of sodium nitroprusside during prolonged infusion in pediatric patients. Pediatr Crit Care Med. 2015 Jun;16(5):397-403.

Han SJ, Englot DJ, Kim H, Lawton MT. Brainstem arteriovenous malformations: anatomical subtypes, assessment of “occlusion in situ” technique, and microsurgical results. J Neurosurg Anesthesiol. 2015 Jan;122(1):107-17.

Hao Q, Zhu YG, Monsel A, Gennai S, Lee T, Xu F, Lee JW. Study of Bone Marrow and Embryonic Stem Cell-Derived Human Mesenchymal Stem Cells for Treatment of Escherichia coli Endotoxin-Induced Acute Lung Injury in Mice. Stem Cells Transl Med. 2015 Jul;4(7):832-40.

Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL. TGF--Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 1;195(3):1182-90.

Hawryluk G, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G. Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data. J Neurotrauma. 2015 Aug 17.

Heinonen JA, Litonius E, Salmi T, Haasio J, Tarkkila P, Backman JT, Rosenberg PH. Intravenous lipid emulsion given to volunteers does not affect symptoms of lidocaine brain toxicity. Basic Clin Pharmacol Toxicol. 2015 Apr;116(4):378-83.

Heinonen JA, Litonius E, Rosenberg PH. Response to ‘In Response to “Intravenous Lipid Emulsion Given to Volunteers does not Affect Symptoms of Lidocaine Brain Toxicity”’. Basic Clin Pharmacol Toxicol. 2015 Sep 11.

Hendrickson CM, Crestani B, Matthay MA. Biology and pathology of fibroproliferation following the acute respiratory distress syndrome. Intensive Care Med. 2015 Jan;41(1):147-50.

Hendrickson CM, Dobbins S, Redick BJ, Greenberg MD, Calfee CS, Cohen MJ. Misclassification of acute respiratory distress syndrome after traumatic injury: The cost of less rigorous approaches. J Trauma Acute Care Surg. 2015 Sep;79(3):417-24.




Hervey-Jumper SL, Li J, Lau D, Molinaro AM, Perry DW, Meng L, Berger MS. Awake craniotomy to maximize glioma resection: methods and technical nuances over a 27-year period. J Neurosurg. 2015 Aug;123(2):325-39.

Heung M, Faubel S, Watnick S, Cruz DN, Koyner JL, Mour G, Liu KD, Cerda J, Okusa MD, Lukaszewski M, Vijayan A; American Society of Nephrology Acute Kidney Injury Advisory Group. Outpatient Dialysis for Patients with AKI: A Policy Approach to Improving Care. Clin J Am Soc Nephrol. 2015 Jul 28.

Hill KD, Sampson MR, Li JS, Tunks RD, Schulman SR, Cohen-Wolkowiez M. Pharmacokinetics of intravenous sildenafil in children with palliated single ventricle heart defects: effect of elevated hepatic pressures. Cardiol Young. 2015 Apr 1:1-9.

Hirsch J, DePalma G, Tsai TT, Sands LP, Leung JM. Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery. Br J Anaesth. 2015 Jan 23.

Hirsch J. Hemodynamic Control and Delirium. Current Anesthesiology Reports. 2015 January.

Howard BM, Kornblith LZ, Hendrickson CM, Redick BJ, Conroy AS, Nelson MF, Callcut RA, Calfee CS, Cohen MJ. Differences in degree, differences in kind: characterizing lung injury in trauma. J Trauma Acute Care Surg. 2015 Apr;78(4):735-41.

Hsu CY, Ballard S, Batlle D, Bonventre JV, Böttinger EP, Feldman HI, Klein JB, Coresh J, Eckfeldt JH, Inker LA, Kimmel PL, Kusek JW, Liu KD, Mauer M, Mifflin TE, Molitch ME, Nelsestuen GL, Rebholz CM, Rovin BH, Sabbisetti VS, Van Eyk JE, Vasan RS, Waikar SS, Whitehead KM, Nelson RG; CKD Biomarkers Consortium. Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium. Clin J Am Soc Nephrol. 2015 May 7;10(5):894-902.

Ji HL, Zhao R, Komissarov AA, Chang Y, Liu Y, Matthay MA. Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites. J Biol Chem. 2015 Feb 27;290(9):5241-55.

Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1102-13.

Kathiriya IS, Nora EP, Bruneau BG. Investigating the transcriptional control of cardiovascular development. Circ Res. 2015 Feb 13;116(4):700-14.

Kim H, Abla AA, Nelson J, McCulloch CE, Bervini D, Morgan MK, Stapleton C, Walcott BP, Ogilvy CS, Spetzler RF, Lawton MT. Validation of the supplemented Spetzler-Martin grading system for brain arteriovenous malformations in a multicenter cohort of 1009 surgical patients. Neurosurgery. 2015 Jan;76(1):25-31; discussion 31-2; quiz 32-3.

Kim H, Nelson J, Krings T, terBrugge KG, McCulloch CE, Lawton MT, Young WL, Faughnan ME; Brain Vascular Malformation Consortium HHT Investigator Group. Hemorrhage rates from brain arteriovenous malformation in patients with hereditary hemorrhagic telangiectasia. Stroke. 2015 May;46(5):1362-4.

Kotloff RM, Blosser S, Fulda GJ, Malinoski D, Ahya VN, Angel L, Byrnes MC, DeVita MA, Grissom TE, Halpern SD, Nakagawa TA, Stock PG, Sudan DL, Wood KE, Anillo SJ, Bleck TP, Eidbo EE, Fowler RA, Glazier AK, Gries C, Hasz R, Herr D, Khan A, Landsberg D, Lebovitz DJ, Levine DJ, Mathur M, Naik P, Niemann CU, Nunley DR, O’Connor KJ, Pelletier SJ, Rahman O, Ranjan D, Salim A, Sawyer RG, Shafer T, Sonneti D, Spiro P, Valapour M, Vikraman-Sushama D, Whelan TP; Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Donor Management Task Force. Management of the Potential Organ Donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Consensus Statement. Crit Care Med. 2015 Jun;43(6):1291-325.

Kozicky LK, Zhao ZY, Menzies SC, Fidanza M, Reid GS, Wilhelmsen K, Hellman J, Hotte N, Madsen KL, Sly LM. Intravenous immunoglobulin skews macrophages to an anti-inflammatory, IL-10-producing activation state. J Leukoc Biol. 2015 Jul 27.

Krings T, Kim H, Power S, Nelson J, Faughnan ME, Young WL, terBrugge KG; Brain Vascular Malformation Consortium HHT Investigator Group. Neurovascular manifestations in hereditary hemorrhagic telangiectasia: imaging features and genotype-phenotype correlations. AJNR Am J Neuroradiol. 2015 May;36(5):863-70.

Kropski JA, Pritchett JM, Zoz DF, Crossno PF, Markin C, Garnett ET, Degryse AL, Mitchell DB, Polosukhin VV, Rickman OB, Choi L, Cheng DS, McConaha ME, Jones BR, Gleaves LA, McMahon FB, Worrell JA, Solus JF, Ware LB, Lee JW, Massion PP, Zaynagetdinov R, White ES, Kurtis JD, Johnson JE, Groshong SD, Lancaster LH, Young LR, Steele MP, Phillips Iii JA, Cogan JD, Loyd JE, Lawson WE, Blackwell TS. Extensive phenotyping of individuals at risk for familial interstitial pneumonia reveals clues to the pathogenesis of interstitial lung disease. Am J Respir Crit Care Med. 2015 Feb 15;191(4):417-26.

Larson MD, Behrends M. Portable infrared pupillometry: a review. Anesth Analg. 2015 Jun;120(6):1242-53.

Larson MD, Gupta DK. Pupillary Reflex Dilation to Predict Movement: A Step Forward Toward Real-time Individualized Intravenous Anesthetics. Anesthesiology. 2015 May;122(5):961-3.

Lee JW, Rocco PR, Pelosi P. Mesenchymal stem cell therapy for acute respiratory distress syndrome: a light at the end of the tunnel? Anesthesiology. 2015 Feb;122(2):238-40.

Lee SM, Takemoto S, Wallace AW. Association between Withholding Angiotensin Receptor Blockers in the Early Postoperative Period and 30-day Mortality: A Cohort Study of the Veterans Affairs Healthcare System. Anesthesiology. 2015 Aug;123(2):288-306.

Lee SM. Landry J, Jones PM, Buhrmann O, Morley-Forster P. Long-term Quit Rates After a Perioperative Smoking Cessation Randomized Controlled Trial Anes Analg. 2015 Mar;120(3):582-7.

Leung JM, Sands LP, Newman S, Meckler G, Xie Y, Gay C, Lee K. Preoperative Sleep Disruption and Postoperative Delirium. J Clin Sleep Med. 2015 Aug 15;11(8):907-13.

Leventhal TM, Liu KD. What a Nephrologist Needs to Know About Acute Liver Failure. Adv Chronic Kidney Dis. 2015 Sep;22(5):376-81.

Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA Jr, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC. Future Research Directions in Asthma: An NHLBI Working Group Report. Am J Respir Crit Care Med. 2015 Aug 25.

Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O’Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D. Unexpected Role for Adaptive Th17 Cells in Acute Respiratory Distress Syndrome. J Immunol. 2015 Jul 1;195(1):87-95.

Li K, Zettlitz KA, Lipianskaya J, Zhou Y, Marks JD, Mallick P, Reiter RE, Wu AM. A fully human scFv phage display library for rapid antibody fragment reformatting. Protein Eng Des Sel. 2015 May 19. pii: gzv024.

Lilly LE, Bonaventura J, Lipnick MS, Block BA. Effect of temperature acclimation on red blood cell oxygen affinity in Pacific bluefin tuna (Thunnus orientalis) and yellowfin tuna (Thunnus albacares). Comp Biochem Physiol A Mol Integr Physiol. 2015 Mar;181:36-44.

Lipshutz AK, Caldwell JE, Robinowitz DL, Gropper MA. An analysis of near misses identified by anesthesia providers in the intensive care unit. BMC Anesthesiol. 2015 Jun 17;15:93.




Liu K, Liu H, Gao WD, Meng L. Cerebral circulation and ischemia: How to monitor it during surgery? Transl Perioper Pain Med. 2015 2(1):2-8.

Liu KD, Hsu CY. When change is not a good thing. Clin Chem. 2015 Jul;61(7):897-9.

Liu KD, Yang W, Go AS, Anderson AH, Feldman HI, Fischer MJ, He J, Kallem RR, Kusek JW, Master SR, Miller ER 3rd, Rosas SE, Steigerwalt S, Tao K, Weir MR, Hsu CY; CRIC Study Investigators. Urine neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease and death in CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2015 Feb;65(2):267-74.

London MJ. From Durban to Boston, a “modest proposal” to improve perioperative cardiovascular risk stratification. Anesth Analg. 2015 Mar;120(3):515-8.

Long LS, Wolpaw JT, Leung JM. Sensitivity and specificity of the animal fluency test for predicting postoperative delirium. Can J Anaesth. 2015 Jun;62(6):603-8.

Makino H, Hokamura K, Natsume T, Kimura T, Kamio Y, Magata Y, Namba H, Katoh T, Sato S, Hashimoto T, Umemura K. Successful serial imaging of the mouse cerebral arteries using conventional 3-T magnetic resonance imaging. J Cereb Blood Flow Metab. 2015 Sep;35(9):1523-7.

Matthay MA, Ware LB. Resolution of Alveolar Edema in Acute Respiratory Distress Syndrome. Physiology and Biology. Am J Respir Crit Care Med. 2015 Jul 15;192(2):124-5.

Matthay MA. Saving lives with high-flow nasal oxygen. N Engl J Med. 2015 Jun 4;372(23):2225-6.

Matthay MA. Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome. Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S54-7.

Matthay MA. Biomarkers to exclude the diagnosis of ventilator-associated pneumonia. Thorax. 2015 Jan;70(1):5-6.

Melia U, Vallverdú M, Borrat X, Valencia JF, Jospin M, Jensen EW, Gambus P, Caminal P. Prediction of Nociceptive Responses during Sedation by Linear and Non-Linear Measures of EEG Signals in High Frequencies. PLoS One. 2015 Apr 22;10(4):e0123464.

Meng L, Gelb AW. Regulation of cerebral autoregulation by carbon dioxide. Anesthesiology. 2015 Jan;122(1):196-205.

Meng L, Berger MS, Gelb AW. The Potential Benefits of Awake Craniotomy for Brain Tumor Resection: An Anesthesiologist’s Perspective. J Neurosurg Anesthesiol. 2015 Oct;27(4):310-7.

Meng L, Weston SD, Chang EF, Gelb AW. Awake craniotomy in a patient with ejection fraction of 10%: considerations of cerebrovascular and cardiovascular physiology. J Clin Anesth. 2015 May;27(3):256-61.

Meng L, Li J, Lu Y, Sun D, Tao YX, Liu R, Luo JJ. Ketamine - A Multifaceted Drug. Transl Perioper Pain Med. 2015 1(2):20-26.

Michel LV, Shaw J, MacPherson V, Barnard D, Bettinger J, D’Arcy B, Surendran N, Hellman J, Pichichero ME. Dual orientation of the outer membrane lipoprotein Pal in Escherichia coli. Microbiology. 2015 Jun;161(6):1251-9.

Moazed F, Calfee CS. Clearing the air. Smoking and incident asthma in adults. Am J Respir Crit Care Med. 2015 Jan 15;191(2):123-4.

Monsel A, Zhu YG, Gennai S, Hao Q, Hu S, Rouby JJ, Rosenzwajg M, Matthay MA, Lee JW. Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice. Am J Respir Crit Care Med. 2015 Aug 1;192(3):324-36.

Neuschwander A, Couffin S, Huynh TM, Cholley B, de Villechenon GP, Achouh P, Fabiani JN, Safran D, Pirracchio R. Determinants of Transcutaneous Ear Lobe CO2 Tension (PtCO2) at 37°C During On-Pump Cardiac Surgery. J Cardiothorac Vasc Anesth. 2015 Aug;29(4):917-23.

Niemann CU, Feiner J, Swain S, Bunting S, Friedman M, Crutchfield M, Broglio K, Hirose R, Roberts JP, Malinoski D. Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function. N Engl J Med. 2015 Jul 30;373(5):405-14.

Nurok M, Cohen N. Distraction Implications for the Practice of Anesthesia. Int Anesthesiol Clin. 2015 Summer;53(3):116-26.

Osorio JA, Breshears JD, Arnaout O, Simon NG, Hastings-Robinson AM, Aleshi P, Kliot M. Ultrasound-guided percutaneous injection of methylene blue to identify nerve pathology and guide surgery. Neurosurg Focus. 2015 Sep;39(3):E2.

Pasero D, Koeltz A, Placido R, Fontes Lima M, Haun O, Rienzo M, Marrache D, Pirracchio R, Safran D, Cholley B. Improving ultrasonic measurement of diaphragmatic excursion after cardiac surgery using the anatomical M-mode: a randomized crossover study. Intensive Care Med. 2015 Apr;41(4):650-6.

Pawlikowska L, Nelson J, Guo DE, McCulloch CE, Lawton MT, Young WL, Kim H, Faughnan ME; Brain Vascular Malformation Consortium HHT Investigator Group. The ACVRL1 c.314-35A>G polymorphism is associated with organ vascular malformations in hereditary hemorrhagic telangiectasia patients with ENG mutations, but not in patients with ACVRL1 mutations. Am J Med Genet A. 2015 Jun;167(6):1262-7.

Pirracchio R, Petersen ML, van der Laan M. Improving propensity score estimators’ robustness to model misspecification using super learner. Am J Epidemiol. 2015 Jan 15;181(2):108-19.

Pirracchio R, Petersen ML, Carone M, Rigon MR, Chevret S, van der Laan MJ. Mortality prediction in intensive care units with the Super ICU Learner Algorithm (SICULA): a population-based study. Lancet Respir Med. 2015 Jan;3(1):42-52.

Potts MB, Lau D, Abla AA, Kim H, Young WL, Lawton MT; UCSF Brain AVM Study Project. Current surgical results with low-grade brain arteriovenous malformations. J Neurosurg. 2015 Apr;122(4):912-20.

Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J. Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice. Shock. 2015 Sep;44(3):272-9.

Prielipp RC, Morell RC, Coursin DB, Brull SJ, Barker SJ, Rice MJ, Vender JS, Cohen NH, Warner MA, Apfelbaum JL. Dialogue on the Future of Anesthesiology. Anesth Analg. 2015 May;120(5):1152-4.

Prielipp RC, Morell RC, Coursin DB, Brull SJ, Barker SJ, Rice MJ, Vender JS, Cohen NH. The Future of Anesthesiology: Should the Perioperative Surgical Home Redefine Us? Anesth Analg. 2015 May;120(5):1142-8.

Rajasekaran S, Tamatam CR, Potteti HR, Raman V, Lee JW, Matthay MA, Mehta D, Reddy NM, Reddy SP. Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L414-24.

Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Manley GT, Dhall SS. Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome. J Neurosurg Spine. 2015 Jul 31:1-7.

Romig M, Tropello SP, Dwyer C, Wyskiel RM, Ravitz A, Benson J, Gropper MA, Pronovost PJ, Sapirstein A. Developing a Comprehensive Model of Intensive Care Unit Processes: Concept of Operations. J Patient Saf. 2015 Apr 23.

Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL; TRALI Study Group. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug;55(8):1838-46.

Sanders RD, Grover V, Goulding J, Godlee A, Gurney S, Snelgrove R, Ma D, Singh S, Maze M, Hussell T. Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection. J Neuroimmunol. 2015 May 15;282:97-103.



Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA; NHLBI ARDS Network. Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar;41(3):574.

Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA; NHLBI ARDS Network. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar;41(3):470-8.

Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care. 2015 Jan;24(1):15-23.

Shieh SC, Liu KD. Finding the key to dialysis catheter lock. Am J Respir Crit Care Med. 2015 May 1;191(9):972-4.

Shim J, DePalma G, Sands LP, Leung JM. Prognostic Significance of Postoperative Subsyndromal Delirium. Psychosomatics. 2015 May 15. pii: S0033-3182(15)00085-7.

Shimada K, Furukawa H, Wada K, Wei Y, Tada Y, Kuwabara A, Shikata F, Kanematsu Y, Lawton MT, Kitazato KT, Nagahiro S, Hashimoto T. Angiotensin-(1-7) protects against the development of aneurysmal subarachnoid hemorrhage in mice. J Cereb Blood Flow Metab. 2015 Jul;35(7):1163-8.

Shimada K, Furukawa H, Wada K, Korai M, Wei Y, Tada Y, Kuwabara A, Shikata F, Kitazato KT, Nagahiro S, Lawton MT, Hashimoto T. Protective Role of Peroxisome Proliferator-Activated Receptor- in the Development of Intracranial Aneurysm Rupture. Stroke. 2015 Jun;46(6):1664-72.

Shunk KA, Zimmet J, Cason B, Speiser B, Tseng EE. Development of a Veterans Affairs hybrid operating room for transcatheter aortic valve replacement in the cardiac catheterization laboratory. JAMA Surg. 2015 Mar 1;150(3):216-22.

Smul TM, Eilers H, Stumpner J. [Nephroprotection - anaesthetic management of renal transplantation]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2015 Sep;50(9):566-75.

Solorzano C, Villafuerte D, Meda K, Cevikbas F, Bráz J, Sharif-Naeini R, Juarez-Salinas D, Llewellyn-Smith IJ, Guan Z, Basbaum AI. Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. J Neurosci. 2015 Jan 14;35(2):648-57.

Stumpner J, Lange M, Roewer N, Kranke P, Smul TM. [Perioperative myocardial protection in non-cardiac surgery]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2015 Sep;50(9):546-55.

Takemoto S, Vail TP, Houman J, Barnes CL. What defines a high-volume hip or knee surgeon in the United States? J Surg Orthop Adv. 2015 Summer;24(2):87-90.

Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, Mabray MC, Pan JZ, Manley GT, Dhall SS. The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings. J Neurosurg Spine. 2015 Jul 10:1-10.

Tang MS, Poles J, Leung JM, Wolff MJ, Davenport M, Lee SC, Lim YA, Chua KH, Loke P, Cho I. Inferred metagenomic comparison of mucosal and fecal microbiota from individuals undergoing routine screening colonoscopy reveals similar differences observed during active inflammation. Gut Microbes. 2015 6(1):48-56.

Terrando N, Yang T, Ryu JK, Newton PT, Monaco C, Feldmann M, Ma D, Akassoglou K, Maze M. Stimulation of the 7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. Mol Med. 2015 Mar 17;20:667-75.

Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May;55(5):947-52.

Tranah GJ, Yaffe K, Katzman SM, Lam ET, Pawlikowska L, Kwok PY, Schork NJ, Manini TM, Kritchevsky S, Thomas F, Newman AB, Harris TB, Coleman AL, Gorin MB, Helzner EP, Rowbotham MC, Browner WS, Cummings SR; Health, Aging and Body Composition Study. Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults. J Gerontol A Biol Sci Med Sci. 2015 Aug 31.

Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29;517(7536):621-5.

Wang L, Wang X, Su H, Han Z, Yu H, Wang D, Jiang R, Liu Z, Zhang J. Recombinant human erythropoietin improves the neurofunctional recovery of rats following traumatic brain injury via an increase in circulating endothelial progenitor cells. Transl Stroke Res. 2015 Feb;6(1):50-9.

Wang L, Shi W, Su Z, Liu X, Su H, Liu J, Liu Z, Lawton MT. Endovascular treatment of severe acute basilar artery occlusion. J Clin Neurosci. 2015 Jan;22(1):195-8.

Ware LB, Calfee CS. Biomarkers of ARDS: what’s new? Intensive Care Med. 2015 Jul 15.

Wei H, Cao X, Zeng Q, Zhang F, Xue Q, Luo Y, Lee JW, Yu B, Feng X. Ghrelin inhibits proinflammatory responses and prevents cognitive impairment in septic rats. Crit Care Med. 2015 May;43(5):e143-50.

Weyker P, Webb C, Naidu RK. Perioperative pain management in a patient with anaphylaxis to full mu-agonists presenting for head and neck salvage surgery. Pain Physician. 2015 Jan-Feb;18(1):E83-5.

Whitlock EL, Kim H, Auerbach AD. Harms associated with single unit perioperative transfusion: retrospective population based analysis. BMJ. 2015 Jun 12;350:h3037.

Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J. Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. Sci Signal. 2015 Aug 25;8(391):ra86.

Wilson J, McKenna D, Liu KD, Matthay MA. Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome — authors’ reply. Lancet Respir Med. 2015 Apr;3(4):e12-3.

Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa E5, Leavitt A, McKenna D, Thompson BT, Matthay MA. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015 Jan;3(1):24-32.

Woodruff PG, Agusti A, Roche N, Singh D, Martinez FJ. Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management. Lancet. 2015 May 2;385(9979):1789-98.

Yang ST, Rodriguez-Hernandez A, Walker EJ, Young WL, Su H, Lawton MT. Adult mouse venous hypertension model: common carotid artery to external jugular vein anastomosis. J Vis Exp. 2015 Jan 27;(95):50472.

Zakus P, Gelb AW, Flexman AM. A survey of mentorship among Canadian anesthesiology residents. Can J Anaesth. 2015 Sep;62(9):972-978.



Jon Matt AldrichPrincipal InvestigatorUCOP, 1/1/2014–12/31/2015Advanced Resuscitation Training (ART)$113,599

Roland BaintonPrincipal InvestigatorAnesthesia Dept, 7/1/2015–6/30/2016Anesthesia Department Research Award$80,000

Principal InvestigatorNIH/NINDS, 2/1/2013–1/31/2016Discovering fundamental metabolic control processes of the blood brain barrier$430,002

Philip BicklerVarious Industry Sponsors, 9/1/1986–12/31/2015Accuracy of pulse oximeters with profound hypoxia$400,000

Marek BrzezinskiPrincipal InvestigatorAnesthesia Dept, 7/1/2014–6/30/2016Anesthesia Department Research Award$70,800

Lee-lynn ChenPrincipal InvestigatorMt. Zion Health Fund, 4/1/2014–12/31/2015Implementation Barriers to the Colorectal ERAS Pathways at Mount Zion$30,000

Principal InvestigatorUCSF Center for Healthcare Value, 7/1/2015–6/30/2016Perioperative Surgical Homes$50,000

Helene ChoquetPrincipal InvestigatorAmerican Heart Association, 7/1/2014–6/30/2016Contribution of Cardiovascular Risk Factors and Inflammation to Familial CCM1 Disease Severity$94,000

Richard FidlerUCSF Catalyst Program, 7/1/2015–7/1/2016SuperAlarm$40,000

Michael GropperPrincipal InvestigatorFAER, 1/1/2015–12/31/20152015 Medical Student Anesthesia Research Fellowship Program$6,200

Principal InvestigatorGordon and Betty Moore Foundation, 10/1/2014–12/31/2015Implementation Grant for EMERGE at University of California, San Francisco$4,000,000

Principal InvestigatorGordon and Betty Moore Foundation, 3/1/2015–12/31/2015Libretto Consortium Task Forces: UCSF$37,500

Zhonghui GuanPrincipal InvestigatorNIH/NINDS, 9/30/2012–8/31/2017Epigenetic regulation in neuropathic pain$947,160

Tomoki HashimotoPrincipal InvestigatorNIH/NINDS, 3/15/2011–2/29/2016Intracranial aneurysm pathogenesis-roles of vascular remodeling and inflammation$1,674,637

Principal InvestigatorNIH/NINDS, 9/1/2013–5/31/2018The Role of Mast Cells in the Pathophysiology of Intracranial Aneurysm$1,726,306

Judith HellmanPrincipal InvestigatorInternational Anesthesia Research Society, 7/1/2015–6/30/2018Endothelial Inflammatory Pathways in Septic Vasculopathy and Organ Injury$750,000

Principal InvestigatorNIH/NIGMS, 7/1/2012–6/30/2017Comprehensive Anesthesia Research Training$1,034,946

Principal InvestigatorSan Francisco Foundation, 1/1/2015–12/31/2015San Francisco Foundation Award$200,000

Jan Hirsch Richard FidlerPrincipal InvestigatorVA Office of Academic Affairs, 7/1/2013–OngoingVA Advanced Fellowship Program in Simulation$300,000

Irfan KathiriyaPrincipal InvestigatorAnesthesia Dept, 7/1/2015–6/30/2016Anesthesia Department Research Award$80,000

Principal InvestigatorFAER, 7/1/2013–6/30/2016Gene regulation during cardiac differentiation$175,000

Helen KimCo-LeaderNIH/NINDS, 9/30/14–7/31/19Project 1: Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformation$563,366

Principal InvestigatorNIH/NINDS, 7/1/2013–6/30/2018Predictors of spontaneous cerebral AVM hemorrhage$2,335,649

Philip KurienPrincipal InvestigatorAnesthesia Dept, 7/1/2015–6/30/2016Anesthesia Department Research Award$40,000

Michael LawtonPrincipal InvestigatorNIH/NINDS, 9/30/2014–7/31/2019Brain Vascular Malformation Consortium: Predictors of Clinical Course$6,179,248

Jae-Woo LeePrincipal InvestigatorNIH/NHLBI, 5/1/2012–4/30/2017Human mesenchymal stem cell microvesicles for the treatment of acute lung injury$1,899,191

Co-Principal InvestigatorNina Ireland Program for Lung Health, 1/1/2015–12/31/2016Integrin Alpha-v Beta-5 Drive Pulmonary Vascular Leak from Ischemia-Reperfusion in Lung Transplantation$24,083

Susan M. LeePrincipal InvestigatorAnesthesia Dept, 7/1/2014–6/30/2016Anesthesia Department Research Award$18,569

Principal InvestigatorUCSF Helen Diller Family Comprehensive Cancer Center, 2/1/2015–1/30/2016The END Perioperative Smoking Pilot Study: A Pilot Randomized Controlled Clinical Trial–”Electronic Nicotine Delivery device (ecigarette) for perioperative smoking cessation in veterans”$29,969

Jacqueline LeungPrincipal InvestigatorNIH/NIA, 6/1/2015–5/31/2017The Effects of Light vs Deep Anesthesia on Postoperative Cognitive Outcomes$444,033

Principal InvestigatorUCOP CHQI/QERM, 7/1/2013–12/30/2015Project to Eradicate Post-Operative Delirium in high-risk patients (PEPOD)$167,000

Bin LiuPrincipal InvestigatorMultiple Myeloma Research Foundation, 8/1/2015–7/31/2017Translational Development of a Novel Antibody-Drug Conjugates Against Myeloma$200,000

Principal InvestigatorNIH/NCI, 3/1/2010–12/31/2015Identifying antigens bound by novel scFvs targeting all subtypes of mesothelioma$1,249,880

Principal InvestigatorNIH/NCI, 6/8/2011–3/31/2016Mapping a clinically significant internalizing tumor epitope space$904,004

Principal InvestigatorNIH/NCI, 8/6/2012–7/31/2017Internalizing human antibody-targeted nanosized siRNA therapeutics$1,607,090

Martin LondonPrincipal InvestigatorAnesthesia Dept, 7/1/2015–6/30/2016Anesthesia Department Research Award $5,500

Active Research Grants

Grantscontinued from previous page


Jennifer LuceroPrincipal InvestigatorAnesthesia Dept, 7/1/2014–6/30/2016Anesthesia Department Research Award$20,520

Principal InvestigatorUCSF Academic Senate, 8/1/2015–1/31/2017Intravenous Nitroglycerin for Prevention of Hysterectomy Extension During Cesarean Delivery in the Second Stage of Labor$29,321

James MarksPrincipal InvestigatorCA Dept of Public Health, 10/15/2012–10/14/2016Identification of monoclonal antibody combinations that neutralize variant botulinum neurotoxins$0

Principal InvestigatorDNA 2.0 Inc, 2/5/2013–2/5/2018Improve the CHO Expression of a scFv Fragment that is moving towards the clinic optimizing the DNA sequence of the scFv and/or leader sequence$0

Principal InvestigatorMerrimack Pharmaceuticals, 3/10/2010–2/28/2016Bispecific Antibodies Targeting Basal Breast Cancers$0

Principal InvestigatorNIH/NCI, 9/24/2014–8/31/2019Antibody Technology Research Center$5,779,613

Principal InvestigatorNIH/NIAID, 2/1/2013–1/31/2018Generation of therapeutic antibodies for serotype F botulism$5,448,316

Principal InvestigatorNIH/NIAID, 6/20/2014–5/31/2017Trispecific Monoclonal Antibody for Botulinum Neurotoxin Intoxication Therapy$1,336,571

Mervyn MazePrincipal InvestigatorNIH/NIGMS, 9/1/2013–8/31/2017Inflammation resolving mechanism dysregulation in postoperative cognitive decline$1,212,399

Claus NiemannPrincipal InvestigatorHRSA, 9/1/2011–11/30/2015The effect of therapeutic hypothermia on deceased donor$2,001,108

Jonathan PanPrincipal InvestigatorFAER, 7/1/2014–6/30/2016Dexmedetomidine Renders Neuroprotection via Modulation of Systemic and Local Immune Responses Following Rodent Spinal Cord Injury$175,000

Ludmila PawlikowskaCo-LeaderNIH/NINDS, 9/30/2014–7/31/2019Genetic and Statistical Analysis Core (GSAC)$417,458

Romain PirracchioPrincipal InvestigatorUC Berkeley, 1/26/2015–3/31/2016Semiparametric Causal Inference Methods for Adaptive Statistical Learning in Trauma Patient-Centered Outcomes Research$92,635

Arun Prakash BuddePrincipal InvestigatorAnesthesia Dept, 7/1/2015–6/30/2016Anesthesia Department Research Award$25,000

Principal InvestigatorNIH/NIGMS, 2/1/2015–1/31/2019Role of Innate Immune Cells and Pathways in Ventilated Lung Ischemia Reperfusion$790,560

James RamsayPrincipal InvestigatorTenax Therapeutics, Inc., 5/15/2015–4/30/2020A Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass$206,097.08

Jeffrey SallPrincipal InvestigatorNIH/NIGMS, 3/1/2015–2/29/2020Testosterone’s role in sex-specific outcomes after early anesthesia$1,524,496

Principal InvestigatorSmartTots, 8/1/2013–6/30/2016Recognition memory following early childhood anesthesia$200,000

Mark SchumacherPrincipal InvestigatorAnesthesia Dept, 7/1/2015–6/30/2016Anesthesia Department Research Award$80,000

Principal InvestigatorNIH/NIDA, 7/15/2015–7/14/2016NIH Pain Consortium Centers of Excellence in Pain Education (CoEPE)$77,867

David Shimabukuro Michael GropperCo-InvestigatorVanderbilt University, 8/15/2012–6/30/2017The MENDS II Study$200,304.45

James SonnerPrincipal InvestigatorAnesthesia Dept, 7/1/2015–6/30/2016Anesthesia Department Research Award$80,000

Principal InvestigatorUCSF Academic Senate, 2/1/2015–1/31/2016Novel Anesthetics$30,000

Una SrejicPrincipal InvestigatorAnesthesia Dept, 7/1/2015–6/30/2016Anesthesia Department Research Award$20,000

Hua SuPrincipal InvestigatorNIH/NHLBI, 1/16/2015–12/31/2018Cell Type-Specific Influences on HHT Pathogenesis$1,582,037

Principal InvestigatorNIH/NINDS, 1/1/2014–12/31/2018Hemodynamics of Cerebral Arteriovenous Malformations$1,633,785.65

Principal InvestigatorNIH/NINDS, 4/15/2014–3/31/2016Soluble VEGF Receptor Therapy for Brain Arteriovenous Malformation$790,313

Principal InvestigatorUCSF Research Evaluation and Allocation Committee (REAC), 1/1/2014–12/31/2015Mouse AVM Models for Mechanistic Study and Therapeutic Test$30,000

Principal InvestigatorThe Community Foundation of Orange & Sullivan, 1/1/2013–OngoingMichael Ryan Zodda Foundation$10,000

Steven TakemotoPrincipal InvestigatorAnesthesia Dept, 7/1/2014–12/31/2015Anesthesia Department Research Award$70,576

Pekka TalkePrincipal InvestigatorMasimo, 8/14/2013–12/31/2015Noninvasive hemoglobin (SpHb) measured with Pulse CO-Oximetry technology$42,266

Arthur WallacePrincipal InvestigatorNCIRE, 3/1/2012–3/1/2016Perioperative Outcomes Epidemiologic Consortium$150,000

Principal InvestigatorSponsor VA National Anesthesia Office, 1/2/2014–1/1/2016VA Anesthesia Quality Improvement Program$100,000

Edward YapPrincipal InvestigatorMt Zion Health Fund, 4/1/2015–3/31/2016Enhanced Recovery Program for Total Mastectomy Patients$29,420

Xiaobing YuPrincipal InvestigatorAnesthesia Dept, 7/1/2013–6/30/2016Anesthesia Department Research Award$50,000

Principal InvestigatorFAER, 7/1/2013–6/30/2016Treating neuropathic pain with spinal cord transplants of genetically modified human pluripotent stem cell-derived GABAergic inhibitory neurons$175,000

Wan ZhuPrincipal InvestigatorHereditary Hemorrhagic Telanglectasia Foundation, 6/1/2015–5/31/2016An Innovative Gene Therapy by Selective and Regulative Neutralizing VEGF in HHT Associated Brain Arteriovenous Malformation$30,000

Department of Anesthesia and Perioperative Care

Saturday Anesthesia Grand Rounds8:00 – 10:00 a.m., HSW-301 / Video Link: TBA

November 7, 2015: Updates in Obstetrical Anesthesia

February 6, 2016: Updates in Trauma Anesthesia

May 7, 2016: Updates in Pediatric Anesthesia


WARC 2016 The 54th Annual Western Anesthesia Residents’ Conference (WARC) will be hosted by UCSF, April 29 to May 1, 2016, at the Westin St. Francis Hotel in San Francisco.

AUA 2016The 63rd Annual Association of University Anesthesiologists Meeting Social Event will be hosted by UCSF on May 19, 2016, at the California Academy of Sciences in San Francisco. Details about the annual meeting can be found here: http://auahq.org/aua-annual-meeting/

San Diego ReceptionUCSF Department of Anesthesia and Perioperative Care Alumni Reception at the American Society of Anesthesiologists Annual Meeting

Sunday, October 25, 2015, 6:00–9:00pmHarbor House Restaurant, 831 W. Harbor Drive, San Diego

Upcoming Events