Radiation Protection Research

From FP6 to FP7

Neale Kelly

Topic %Radiobiology 46Epidemiology 25

Medical uses 7Risk and emergency

management15

Radioecology and

environmental protection

5

Dosimetry 0.6Education and training 1

Other topics

Risks at low and

protracted doses

Distribution of FP6 budget

Trends between FP5 and FP6

FP5 % FP6 %

Risks at low doses 47 71

Medical uses and natural radiation

12 7

Risk and emergency management

18 15

Radioecology 10 5

Dosimetry 13 0.6

Radiobiology – Integrated Projects

RISC-RAD (16 M€) – multi-disciplinary approach to better understanding of mechanisms and quantification of risk

DNA damage and repair, genomic instability, mechanisms of tumorigenesis, genetic susceptibility, individual sensitivity, modelling

NOTE (11 M€) – non targeted effects of radiationmechanisms underlying NTE, effect on cancer risk at low doses, influence on non-cancer disease, etcimplications for radiation protection

Radiobiology - STREPS

ERA-PRO (0.4 M€) – database of animal radiobiology studies in EU, US and JAP since 1960

GENRISK-T (4.4 M€) - genetic influence on the risk of radiation induced thyroid cancer

GENEPI-ENTB2 (1.5 M€) - tissue bank for use in studies of the genetic determinants of individual radiosensitivity

GENEPI-lowRT (1.8 M€) – influence of genetic factors on individual radiosensitivity

Epidemiology – Integrated Project

SOUL - Southern Urals cohorts (12 M€)Cohorts

o Mayak (external, plutonium)o Techa River (external, strontium)

Effectso cancer incidenceo cancer mortalityo non cancer diseases

Collaborationo RF, US and EUo Opportunities to broaden

Epidemiology - STREPS

ALPHA RISK – exposures to α radiation (4.4 M€)Cohorts

o U minerso domestic radono fuel cycle workers (U, Pu)

GENE RAD RISK – role of genetic susceptibility and radiation exposure in breast cancer (2 M€)

RACE – cardiovascular disease in breast cancer patients treated with radiotherapy (1.4 M€)

Medical Uses of Radiation

CT (3.1 M€) – optimisation and justification of CT for a wide range of clinical applications including cardiac, interventional and paediatric

good practice guidelines

SENTINEL (0.7 M€) – optimisation and justification of new and emerging imaging techniques (excluding CT) in diagnostic and interventional radiology

physical and clinical image quality criteriagood practice guidelines

Radioecology and Protection of the Environment

ERICA (3.9 M€) – integrated approach to assessing and managing the impact of radiation on the environment

PROTECT (0.6 M€) – evaluation of the merits and practicability of different approaches for regulating protection of the environment

FUTURAE (0.7 M€) – evaluation of potential for establishing deeper and sustainable integration of European research on radioecology, in particular through a Network of Excellence

Emergency Management

EURANOS (14 M€) – emergency management and rehabilitation strategies

handbooks on countermeasurs for agricultural and inhabited areasimproved decision support system (RODOS)demonstration projectsstrategies for and guidance on rehabilitationuser driven

TMT Handbook (0.7 M€) - monitoring and treatment of populations exposed to malevolent uses or radiation or radioacative materials

Protection of the Workplace

CONRAD (0.3 M€) – network to maintain and enhance European competence in radiation protection dosimetry

analysis of options for achieving deeper and sustainable integration of European researchworking groups on computational dosimetry, internal dosimetry, complex mixed radiation fields and occupational exposure in medical radiology

Further information

links to reports of completed projects in FP5http://www.cordis.lu/fp5-euratom/src/lib_finalreports.htm

links to ongoing projects in FP6http://europa.eu.int/comm/research/energy/fi/fi_pubs/article_1

186_en.htm

G N Kelly, EC, DG Research george-neale.kelly@ec.europa.eu

7th Framework Programme (EURATOM) (2007-2011/13)

Nuclear FusionNuclear Fission and Radiation Protection

management of radioactive wastereactor systemsradiation protectioninfrastructureshuman resources and training

Underlying Principles

Continuity with the FP6Simplification

reduce “red tape”IPRfunding schemesreporting

Content – Radiation Protection

Quantification of risks for low and protracted exposures

epidemiological studiesunderstanding mechanisms

Medical uses of radiationenhance their safety and efficacy (in diagnosis and therapy) through new methodological and technological developments achieve balance between benefits and risks

Content – Radiation Protection (cont’d)

Emergency management and rehabilitationimprove coherence through development of common tools and strategiesdemonstrate efficacy in operational environments

Malevolent usesComplementary to EC Security programme

Other topics (dosimetry, radioecology, natural…)more effective integration of national research activities

Budgetary Resources

FP6190 M€ for 4 years (≈ 50 M€ per year)

o RP 50 M€

FP7 – initial Commission proposal394 M€ for 5 years (≈ 80 M€ per year)

o single budget – no subdivision for RP

FP7 – revised Commission proposal287 M€ for 5 years (≈ 60 M€ per year)

Work Programmes and Calls

WP under preparationadoption by Commission in December (subject to timely approval of FP and SP by Council and Parliament)

First call in late ’06 or early ’07First deadline – probably second quarter of ’07WP to be updated annually

Funding Schemes

Collaborative ProjectsNetworks of ExcellenceCoordination and Support ActionsActions to promote and develop human resources and mobility

Funding Schemes (cont’d)

Collaborative projects

Details still under discussion between COM/Council/EP

Maximum of 50% contribution likely to the be the general rule with some exceptions Additional Cost Model will probably disappear

Funding Schemes (cont’d)

Reimbursement at 100%Coordination and support actionsTraining, career developmentFrontier research (ERC)

Draft Work Programme 2007

Undergoing inter-service consultation within the CommissionSent to Members of CCE Fission Committee and will be informally discussed in early NovemberTo be finalised in December subject to approval of Framework and Specific ProgrammesContent/Timing – influenced, inter alia, by status of and expected outcome of ongoing from FP6 projectsIndicative budget – 52 M€

Quantification of risk for low and protracted exposures

Non cancer effects, especially cardio- and cerebro-vascular diseases

One or more Collaborative Project/s

Feasibility of establishing a prospective cohort of medically exposed children

A Support Action

Medical uses of radiation in diagnosis and therapy

Reducing patient exposureAcquisition of key information for sound and scientifically based judgements on use of existing and emerging imaging techniquesQuality criteriaSynergy through networkingBroadly applicable methodologies for assessing and reducing doses to peripheral tissues in therapy

One or more Collaborative Project/s and/or Coordination Action/s

Emergency Management and Rehabilitation

Optimising the design of monitoring systems

o Develop methodology for optimising the design of monitoring systems at national or regional levels to better exploit state of the art decision support systems for emergency management (ie, to achieve more timely and better quality decisions)

A collaborative project

Supporting infrastructure

Data bases and tissue banksDesign, refurbish, construct, operate and/or provide access to key data-bases or tissue banks for use in radiation protection research

One or more Collaborative Project/Coordination Action or Support Action

Radiobiology infrastructuresAssess status of radiobiology infrastructures in Europe and evaluate adequacy for low-dose risk research

A Support Action

Actions supporting programme implementation and other activities

Dissemination of programme results

Contributing to strategic objectives, notably ERA

Preparation of future activities

One or more Support Actions

Work Programme 2008 and beyond?

WP 2008expected to focus on low dose risk research –radiobiology and epidemiology

WP 2009as WP 2008 plus further research on medical uses of radiationConsideration to be given to NoE in fields of dosimetryand radioecology subject to outcome of FP6 projects