Fluorescent core-shell silica nanoparticles

Jianming Kang 2013.3.30

ContentsIntroduction 1

Preparation2

Applications3

Conclusions4

Novel nanoscale fluorescent materials are integral to the progress of emergent fields such as nanobiotechnology and facilitate new research in a variety of contexts. Sol–gel derived silica is an excellent host material for creating fluorescent nanoparticles by the inclusion of covalently-bound organic dyes. Significant enhancements in the brightness and stability of organic dye emission can be achieved for silica-based core–shell nanoparticle architectures at length scales down to tens of nanometers with narrow size distributions.

Several nanoscale fluorescent materials

1.Substitution reaction Ammonolysis reaction other substitution reaction

2. Addition reaction C=C bond C=N bond

3. Condensation reaction

Reaction types

Ammonolysis reaction

Other substitution reaction

C=C bond addition reaction

C=N bond addition reaction

Condensation reaction

Applications in biology and medicine

pH sensing

Cell imaging

Throughout my presentation, many kinds of reaction types have been introduced that demonstrate the versatility of fluorescent silica nanoparticles. Also, we can add different shells to create probes tailored to explore specific biological questions at near-molecular scale. The versatility provides a wide and open space for innovative research for nanobiotechnology and beyond.

感谢各位老师和同学欢迎大家提出宝贵意见

Thank you!