Inpharma 1290 - 2 Jun 2001

■ Fludarabine plus cyclophosphamide, with orwithout mitoxantrone, is effective in recurrent NHL(non-Hodgkin’s lymphoma), according to the results ofan Italian study. The study included 53 patients withrecurrent low-grade NHL who received ≤ 6 courses,repeated every 28 days, of IV fludarabine 25 mg/m2

plus IV cyclophosphamide 300 mg/m2, each given ondays 1–3, with or without IV mitoxantrone 10 mg/m2

on day 1. Response rates were similar for the 2groups(95% without, 84% with, mitoxantrone). 58% ofpatients achieved complete remission (45% of patientsafter only 3 courses) and 30% achieved partialremission. The 3-year survival rate was 52.5%.Santini G, et al. Fludarabine in combination with cyclophosphamide or withcyclophosphamide plus mitoxantrone for relapsed or refractory low-grade non-Hodgkin’s lymphoma. Haematologica 86: 282-286, Mar 2001 800862862

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Inpharma 2 Jun 2001 No. 12901173-8324/10/1290-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved