xls file · web view1080622-86-1 cp-466722 is an potent and reversible atm inhibitor....

Anti-cancer Compound Library (96-well)

Product Details:Formulation A unique collection of 349 bioactive compounds

Container

Stability2 weeks | 4°C | in DMSO

Shipping Blue ice

Packaged under inert Yes

Plate layout: L3000-01

1 2 3 4 5

a ABT-737 Linifanib (ABT-869) ABT-888 (Veliparib) Axitinib

b Bosutinib (SKI-606) Dovitinib (TKI-258)

c Nilotinib (AMN-107) PD0325901 PI-103

d Vorinostat (SAHA) Y-27632 2HCl Elesclomol

e Masitinib (AB1010) GDC-0941 SB 431542

f SU11274 Belinostat (PXD101) Iniparib (BSI-201)

g BTZ043 racemate GDC-0879 LY294002

h XL147 TW-37


1 2 3 4 5

a Andarine (GTX-007)

b SNS-314 Mesylate E7080 (Lenvatinib) ABT-751

For more information on Selleck library service, please contact us via +1-832-582-8158 or [email protected]

96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

3 months | ﹣20°C | in DMSO

6 months | ﹣80°C | in DMSO

ABT-263 (Navitoclax)

Cediranib (AZD2171)

CI-1040 (PD184352)

Dasatinib (BMS-354825)

Motesanib Diphosphate (AMG-706)

Rapamycin (Sirolimus)

Vandetanib (Zactima)

VX-680 (MK-0457, Tozasertib)

Crizotinib (PF-02341066)

AUY922 (NVP-AUY922)

Vismodegib (GDC-0449)

Brivanib (BMS-540215)

Rucaparib (AG-014699 , PF-01367338)

Vatalanib 2HCl (PTK787)

PD 0332991 (Palbociclib) HCl

Triciribine (Triciribine phosphate)

Everolimus (RAD001)

Pemetrexed (Alimta)

17-AAG (Tanespimycin)

17-DMAG HCl (Alvespimycin)

SNS-032 (BMS-387032)

Capecitabine (Xeloda)

Ganetespib (STA-9090)

c BIIB021 XAV-939 ENMD-2076 BIBR 1532

d Thalidomide CUDC-101 Exemestane Irinotecan Cladribine

e Imiquimod Bendamustine HCL Bleomycin sulfate

f Epirubicin HCl Etoposide (VP-16) Ku-0063794

g Temozolomide Vincristine Vinblastine JNJ-7706621

h BX-795 Carmofur Epothilone A


1 2 3 4 5

a Dexamethasone Dorzolamide HCl

b SB 525334 PHA-793887 PIK-93

c AT7519 MK-1775 Quizartinib (AC220) AZD7762

d BMS 777607 Pomalidomide KU-60019 Tie2 kinase inhibitor

e Estrone

f Azacitidine (Vidaza) Teniposide (Vumon) Simvastatin (Zocor) Lomustine (CeeNU)

g Sodium butyrate Maraviroc PF 573228 Bexarotene

h MLN9708 SB 743921 GSK461364 SGI-1776 free base BMS 794833


1 2 3 4 5

a SB590885 TAME CAL-101 (GS-1101) LY2157299

b Gossypol

Regorafenib (BAY 73-4506)

Abitrexate (Methotrexate)

Nelarabine (Arranon)

Oxaliplatin (Eloxatin)

Evista (Raloxifene HCl)

Amuvatinib (MP-470)

Altretamine (Hexalen)

Floxuridine (Fludara)

Rigosertib (ON-01910)

Epothilone B (EPO906)

Ruxolitinib (INCB018424)

Doxercalciferol (Hectorol)

AEE788 (NVP-AEE788)

XL765 (SAR245409)

BIRB 796 (Doramapimod)

Aminoglutethimide (Cytadren)

Disulfiram (Antabuse)

Betapar (Meprednisone)

Busulfan (Myleran, Busulfex)

Ranolazine (Ranexa)

Cyclophosphamide monohydrate

Telatinib (BAY 57-9352)

CX-4945 (Silmitasertib)

(-)-Epigallocatechin gallate

Cyclosporin A (Cyclosporine A)

Phloretin (Dihydronaringenin)

c Mitoxantrone HCl Pioglitazone (Actos)

d GSK2126458 MK-0752 PF-3845

e CH5132799 KX2-391 LY2109761 YO-01027 Geldanamycin

f PAC-1 AZ628 AT-406 Canagliflozin

g APO866 (FK866) Sirtinol CEP33779 INK 128 (MLN0128) Torin 2

h Pazopanib

Mycophenolic (Mycophenolate)

Rosiglitazone (Avandia)

Medroxyprogesterone acetate

DCC-2036 (Rebastinib)

NU7441 (KU-57788)

TG101348 (SAR302503)

BAY 11-7082 (BAY 11-7821)

CHIR-99021 (CT99021) HCl

Daunorubicin HCl (Daunomycin HCl)

Dexamethasone acetate


Product Details:A unique collection of 349 bioactive compounds

2 weeks | 4°C | in DMSO

Blue ice

Yes


6 7 8 9 10 11

Afatinib (BIBW2992)

Erlotinib HCl Gefitinib (Iressa) Imatinib Mesylate

Sorafenib (Nexavar) STF-62247 Trichostatin A (TSA)

Olaparib (AZD2281) Nutlin-3

PHA-665752 ZSTK474 SB 216763 SB 203580 MK-2206 2HCl PD153035 HCl

PCI-24781 Linsitinib (OSI-906) KU-55933 GSK1904529A PF-04217903 JNJ-26481585

BI 2536 SGX-523 GSK690693 JNJ-38877605

SRT1720 YM155 MLN8237 (Alisertib) AT9283


6 7 8 9 10 11

Cyclopamine Paclitaxel (Taxol)

Cisplatin CYC116 WZ4002 Ostarine (MK-2866)

+1-832-582-8158 or [email protected]

96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Saracatinib (AZD0530)

AZD6244 (Selumetinib)

BEZ235 (NVP-BEZ235)

BIBF1120 (Vargatef)

Bortezomib (Velcade)

Deforolimus (Ridaforolimus)

Lapatinib Ditosylate (Tykerb)

Lenalidomide (Revlimid)

Sunitinib Malate (Sutent)

Tandutinib (MLN518)

Temsirolimus (Torisel)

Entinostat (MS-275, SNDX-275)

Enzastaurin (LY317615)

BMS-599626 (AC480)

Obatoclax mesylate (GX15-070)

Danusertib (PHA-739358)

TAE684 (NVP-TAE684)

Mocetinostat (MGCD0103)

Abiraterone (CB-7598)

Barasertib (AZD1152-HQPA)

Docetaxel (Taxotere)

Gemcitabine HCl (Gemzar)

Roscovitine (Seliciclib, CYC202)

Valproic acid sodium salt (Sodium valproate)

JNJ 26854165 (Serdemetan)

PIK-90 Anastrozole

Decitabine Dimesna PIK-75 Tivozanib (AV-951)

Carboplatin Clofarabine YM201636 OSI-930

Idarubicin HCl Topotecan HCl 2-Methoxyestradiol Letrozole Leucovorin Calcium

Celecoxib PD173074 WYE-354 IC-87114

Ftorafur Ifosfamide Megestrol Acetate Mercaptopurine


6 7 8 9 10 11

Isotretinoin Pelitinib (EKB-569) Zileuton

LY2228820 SB939 (Pracinostat)

R406 (free base) DMXAA (ASA404) EX 527 Febuxostat (Uloric) Dapagliflozin AZD8055

Ubenimex (Bestatin) Cytarabine Tretinoin (Aberela) Ezetimibe (Zetia)

Estradiol

D-glutamine Flutamide (Eulexin)

Lapatinib Neratinib (HKI-272) AG14361 MLN2238

OSI-420 Formestane DAPT (GSI-IX) Cyt387


6 7 8 9 10 11

BI6727 (Volasertib) Palomid 529 WP1130 AR-42 (HDAC-42) CP-466722

Imatinib (Gleevec)

Aprepitant (MK-0869)

Bicalutamide (Casodex)

Fulvestrant (Faslodex)

Raltitrexed (Tomudex)

Doxorubicin (Adriamycin)

Adrucil (Fluorouracil)

Clafen (Cyclophosphamide)

Dacarbazine (DTIC-Dome)

Fludarabine Phosphate (Fludara)

MDV3100 (Enzalutamide)

Vemurafenib (PLX4032)

Pamidronate Disodium

Streptozotocin (Zanosar)

Ispinesib (SB-715992)

Tipifarnib (Zarnestra)

Zibotentan (ZD4054)

Ponatinib (AP24534)

Fludarabine (Fludara)

Mycophenolate mofetil (CellCept)

Tosedostat (CHR2797)

Prednisone (Adasone)

Triamcinolone Acetonide

Hydrocortisone (Cortisol)

Gemcitabine (Gemzar)

Azathioprine (Azasan, Imuran)

Mesna (Uromitexan, Mesnex)

Toremifene Citrate (Fareston, Acapodene)

Hydroxyurea (Cytodrox)

Fluvastatin sodium (Lescol)

Tamoxifen Citrate (Nolvadex)

Procarbazine HCl (Matulane)

Vinpocetine (Cavinton)

LDE225 (NVP-LDE225, Erismodegib)

R935788 (Fostamatinib disodium, R788 disodium)

Irinotecan HCl Trihydrate (Campto)

BKM120 (NVP-BKM120)

Salinomycin (Procoxacin)

Quercetin (Sophoretin)

Coenzyme Q10 (CoQ10)

Chrysophanic acid (Chrysophanol)

Itraconazole (Sporanox)

Lonidamine TAK-733 LDN193189 LY2603618 (IC-83) GW3965 HCl

NVP-BSK805 2HCl WAY-362450 A-769662

AMG 900 PF-03814735 PH-797804 AZ 3146

3-Methyladenine Nocodazole GW4064

RG108 TPCA-1 Torin 1 PF-562271 S-Ruxolitinib

Anagrelide HCl Triptolide Empty Empty Empty

Mifepristone (Mifeprex)

GSK1120212 (Trametinib)

Flavopiridol (Alvocidib) HCl

PCI-32765 (Ibrutinib)

Dacomitinib (PF299804,PF-00299804)

Crenolanib (CP-868596)

Dalcetrapib (JTT-705)

Tofacitinib (CP-690550, Tasocitinib)

Sotrastaurin (AEB071)

Desmethyl Erlotinib (CP-473420)

Fingolimod (FTY720)


Product Details:A unique collection of 349 bioactive compounds

2 weeks | 4°C | in DMSO

Blue ice

Yes


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Item Name Smiles Plate LocationABT-263 (Navitoclax) C1=CC(=CC=C1C2=C(CC(CC2)(Ca1-L3000-01

ABT-737 C1=CC(=CC=C1C(=O)NS(C2=CC=a2-L3000-01

Linifanib (ABT-869) C12=CC=CC(=C1C(=NN2)N)C3=a3-L3000-01

ABT-888 (Veliparib) C1=CC=C2C(=C1C(N)=O)N=C(Na4-L3000-01

Axitinib C1(=CC=CC=C1C(=O)NC)SC2=Ca5-L3000-01

Saracatinib (AZD0530) C1=C(C=C2C(=C1OC3CCOCC3)a6-L3000-01

AZD6244 (Selumetinib) C1=C2C(=C(C(=C1C(NOCCO)=Oa7-L3000-01

BEZ235 (NVP-BEZ235) C12=CN=C3C(=C1N(C(N2C)=O)a8-L3000-01

BIBF1120 (Vargatef) C1=C(C=C2C(=C1)/C(C(N2)=O) a9-L3000-01

Afatinib (BIBW2992) C1(=C(C=C(C=C1)NC2=NC=NC3=a10-L3000-01

Bortezomib (Velcade) C1=CN=CC(=N1)C(N[C@H](C(Na11-L3000-01

Bosutinib (SKI-606) N1=CC(=C(C2=CC(=C(C=C12)Ob1-L3000-01

Cediranib (AZD2171) C1(=C(C=C2C(=C1)C(=NC=N2) b2-L3000-01

Dovitinib (TKI-258) C1=CC=C(C2=C1NC(C(=C2N)C3b3-L3000-01

CI-1040 (PD184352) C1=C(C(=C(C(=C1)C(NOCC2CC2b4-L3000-01

Dasatinib (BMS-354825) N1=C(N=C(C=C1NC2=NC=C(S2)b5-L3000-01

Deforolimus (Ridaforolimus) [C@H]1(C[C@@H](CC[C@@H]1OPb6-L3000-01

Erlotinib HCl C1(=CC=CC(=C1)C#C)NC2(=NCb7-L3000-01

Gefitinib (Iressa) C1(=C(C=C2C(=C1)N=CN=C2NCb8-L3000-01

Imatinib Mesylate C1(=CC=C(C(=C1)NC2=NC=CC(b9-L3000-01

Lapatinib Ditosylate (Tykerb) C1(=C(C=C2C(=C1)N=CN=C2NC3b10-L3000-01

Lenalidomide (Revlimid) C1=CC(=C2C(=C1)C(N(C2)C3C(b11-L3000-01

Motesanib Diphosphate (AMG-706) C1(=CN=CC=C1CNC2=C(C=CC=N2c1-L3000-01

Nilotinib (AMN-107) C1(=CC=C(C(=C1)NC2=NC=CC(=c2-L3000-01

PD0325901 C1=CC(=C(C(=C1C(=O)NOC[C@Hc3-L3000-01

PI-103 C12=C(N=C(N=C1N3CCOCC3)Cc4-L3000-01

Rapamycin (Sirolimus) [C@@H]1([C@@H](C[C@@H](CCc5-L3000-01

Sorafenib (Nexavar) C1(=CC=C(C=C1C(F)(F)F)NC(N c6-L3000-01

STF-62247 N1=CC=C(C=C1)C2=CSC(=N2)Nc7-L3000-01

Sunitinib Malate (Sutent) C1(=CC=C2C(=C1)/C(C(N2)=O) c8-L3000-01

Tandutinib (MLN518) C1=C(C(=CC2=C1N=CN=C2N3Cc9-L3000-01

Temsirolimus (Torisel) [C@H]1(C[C@@H](CC[C@@H]1OCc10-L3000-01

Trichostatin A (TSA) C1=C(C=CC(=C1)C([C@@H](/C=c11-L3000-01

Vandetanib (Zactima) C12=C(C(=NC=N1)NC3=C(C=C(d1-L3000-01

Vorinostat (SAHA) C1=CC=CC(=C1)NC(=O)CCCCCd2-L3000-01

VX-680 (MK-0457, Tozasertib) C1(=CC(=NC(=N1)SC2=CC=C(Cd3-L3000-01

Y-27632 2HCl [C@@H]1(CC[C@@H](CC1)[C@@Hd4-L3000-01

Elesclomol C1=CC=C(C=C1)C(N(NC(CC(NNd5-L3000-01

Entinostat (MS-275, SNDX-275) C1=C(C=CC(=C1)C(NC2=CC=C d6-L3000-01

Enzastaurin (LY317615) C1=CC=C2C(=C1)C(=CN2C3CCNd7-L3000-01

BMS-599626 (AC480) C1(CN[C@@H](CO1)COC(NC2=Cd8-L3000-01

Obatoclax mesylate (GX15-070) C1(=CC=C2C(=C1)C=C(N2)C3C=Cd9-L3000-01

Olaparib (AZD2281) C1=CC=CC2=C1C(=NNC2=O)CC3d10-L3000-01

Nutlin-3 N1(C(C(N=C1C2=C(C=C(C=C2)Od11-L3000-01

Masitinib (AB1010) C1(=C(C=C(C=C1)NC(=O)C2=C e1-L3000-01

GDC-0941 C1(=CC=CC2=C1C=NN2)C3=NC(e2-L3000-01

SB 431542 C1=CC=CC(=N1)C2NC(=NC=2C3e3-L3000-01

Crizotinib (PF-02341066) C1(=CC(=C(N=C1)N)O[C@@H](Ce4-L3000-01

AUY922 (NVP-AUY922) C1(=CC(=C(C=C1C2=C(C(=NO2e5-L3000-01

PHA-665752 C1=CC=C(C(=C1Cl)CS(C2=CC3=e6-L3000-01

ZSTK474 N1=C(N=C(N=C1N2CCOCC2)N3e7-L3000-01

SB 216763 C1=CC=CC2=C1N(C=C2C3=C(C(e8-L3000-01

SB 203580 N1=CC=C(C=C1)C2=C(N=C(N2)e9-L3000-01

MK-2206 2HCl C1(=CC=CC=C1)C2(=C(N=C3C(=e10-L3000-01

PD153035 HCl C1(=C(C=C2C(=C1)C(=NC=N2)Ne11-L3000-01

SU11274 C1(=CC=CC(=C1)N(C)S(C2=CC3f1-L3000-01

Vismodegib (GDC-0449) C1(=C(C=C(C=C1)NC(C2=CC=C(f2-L3000-01

Brivanib (BMS-540215) C12=C(C(=C(C=C1)OC3=NC=NNf3-L3000-01

Belinostat (PXD101) C1(=CC=CC(=C1)/C=C/C(NO)=Of4-L3000-01

Iniparib (BSI-201) C1=CC(=C(C=C1C(N)=O)[N+](=O)f5-L3000-01

PCI-24781 C1=CC=C2C(=C1)OC(=C2CN(C)f6-L3000-01

Linsitinib (OSI-906) C1=C(C=C2C(=C1)C=CC(=N2)Cf7-L3000-01

KU-55933 C1=CC=C2C(=C1)SC3=C(S2)C f8-L3000-01

GSK1904529A C1=C(C(=C(C=C1)F)NC(C2=C(Cf9-L3000-01

PF-04217903 C12=CC=CN=C1C=CC(=C2)CN3f10-L3000-01

JNJ-26481585 C1=CC=C2C(=C1)C(=CN2C)CNCf11-L3000-01

BTZ043 racemate C1(=CC(=C2C(=C1)C(N=C(S2)N3g1-L3000-01

Rucaparib (AG-014699 , PF-01367338) C1(C2C=CC(=CC=2)CNC)(=C3C4g2-L3000-01

Vatalanib 2HCl (PTK787) C1(=CC=C2C(=C1)C(=NN=C2CC3g3-L3000-01

GDC-0879 C(CN1N=C(C(=C1)C2=CC=C3C(g4-L3000-01

LY294002 C1=CC(=C2C(=C1)C(C=C(O2)N g5-L3000-01

Danusertib (PHA-739358) C1(=CC=CC=C1)[C@H](C(N2CCg6-L3000-01

TAE684 (NVP-TAE684) C1=CC(=CC(=C1NC2=NC=C(C(=g7-L3000-01

BI 2536 C1(=CC=C(C(=C1)OC)NC2=NC=g8-L3000-01

SGX-523 C1=C2C(=CC(=C1)SC3N4C(=NNg9-L3000-01

GSK690693 C12=C(C(=CN=C1C#CC(C)(O)C g10-L3000-01

JNJ-38877605 N1=CC=CC2=C1C=CC(=C2)C(C3g11-L3000-01

PD 0332991 (Palbociclib) HCl N1(=C(N=C2C(=C1)C(=C(C(N2Ch1-L3000-01

Triciribine (Triciribine phosphate) [C@H]1([C@@H]([C@H](O[C@@h2-L3000-01

XL147 C1=CC=C2C(=C1)N=C(C(=N2)Nh3-L3000-01

Everolimus (RAD001) C(O)CO[C@H]1[C@@H](C[C@@Hh4-L3000-01

TW-37 C1=CC=CC(=C1C(C)(C)C)S(C2=h5-L3000-01

Mocetinostat (MGCD0103) C(C1C=CC(=CC=1)CNC2N=C(C=h6-L3000-01

Abiraterone (CB-7598) C1[C@@H](CC2[C@](C1)([C@]3(h7-L3000-01

SRT1720 N1(=C(C=NC2=CC=CC=C12)C(=h8-L3000-01

YM155 C1(=CC=C2C(=C1)C(C3=C(C2=Oh9-L3000-01

MLN8237 (Alisertib) C1=CC=C(C(=C1OC)C2=NCC3=Ch10-L3000-01

AT9283 N(C(=O)NC1C(=NNC=1)C2NC3Ch11-L3000-01

Pemetrexed (Alimta) C([C@H](NC(C1C=CC(=CC=1)CCCa1-L3000-02

Andarine (GTX-007) C([C@@](COC1C=CC(=CC=1)NC(=a2-L3000-02

17-AAG (Tanespimycin) C1(=C2C(C(=CC1=O)NC(C(=C\Ca3-L3000-02

17-DMAG HCl (Alvespimycin) C1(=C2C(C(=CC1=O)NC(C(=C\Ca4-L3000-02

SNS-032 (BMS-387032) C1(=CN=C(O1)CSC2=CN=C(S2)a5-L3000-02

Cyclopamine C1[C@@H](CC2[C@](C1)([C@]3([a6-L3000-02

Barasertib (AZD1152-HQPA) C1(=CC=C2C(=C1)N=CN=C2NCa7-L3000-02

Docetaxel (Taxotere) C1=CC=CC=C1C(=O)O[C@H]2[C@a8-L3000-02

Gemcitabine HCl (Gemzar) C1(N=C(C=CN1[C@@H]2O[C@H](a9-L3000-02

Paclitaxel (Taxol) C1=CC=CC(=C1)C(=O)N[C@H]( a10-L3000-02

Roscovitine (Seliciclib, CYC202) N1=C2C(=C(N=C1N[C@@H](COa11-L3000-02

SNS-314 Mesylate C12(=C(N=CN=C1NCCC3SC(=NCb1-L3000-02

Capecitabine (Xeloda) N1=C(C(=CN(C1=O)[C@@H]2O[b2-L3000-02

Ganetespib (STA-9090) N1NC(N(C=1C2C(=CC(=C(C=2)Cb3-L3000-02

E7080 (Lenvatinib) C1(=C(C=C2C(=C1)C(=CC=N2)Ob4-L3000-02

ABT-751 C1=C(C=CC(=C1)S(=O)(=O)NC b5-L3000-02

Cisplatin [Pt](N)(Cl)(Cl)N b6-L3000-02

Valproic acid sodium salt (Sodium valproCCCC(C([O-])=O)CCC.[Na+] b7-L3000-02

CYC116 C1(=NC=CC(=N1)C2SC(=NC=2 b8-L3000-02

JNJ 26854165 (Serdemetan) C1=C2C(=CC=C1)NC=C2CCNC3b9-L3000-02

WZ4002 C1(=CC(=C(C=C1)NC2=NC=C(Cb10-L3000-02

Ostarine (MK-2866) C([C@@](COC1C=CC(=CC=1)C#Nb11-L3000-02

BIIB021 N1=C(N=C2C(=C1Cl)N=CN2CC3=c1-L3000-02

Regorafenib (BAY 73-4506) C1=NC(=CC(=C1)OC2=CC(=C(C=c2-L3000-02

XAV-939 C1=CC(=CC=C1C(F)(F)F)C2=NCc3-L3000-02

ENMD-2076 C1(N=C(C=C(N=1)N2CCN(CC2) c4-L3000-02

BIBR 1532 C1=CC=C2C(=C1)C=C(C=C2)/C(c5-L3000-02

PIK-90 C1=C(C(=C2C(=C1)C3N(C(=N2 c6-L3000-02

Anastrozole C1=C(C=C(C=C1CN2C=NC=N2)C(c7-L3000-02

Aprepitant (MK-0869) N1NC(NC=1CN2[C@H]([C@H](OCc8-L3000-02

Bicalutamide (Casodex) C(C(CS(=O)(=O)C1C=CC(=CC=1)c9-L3000-02

Fulvestrant (Faslodex) C1(C=CC2[C@@]3(CC[C@]4([C@Hc10-L3000-02

Raltitrexed (Tomudex) C([C@H](CCC(=O)O)NC(=O)C1=c11-L3000-02

Thalidomide C1(N(C(C2C=CC=CC1=2)=O)C3d1-L3000-02

CUDC-101 C12=C(N=CN=C1NC3=CC(=CC=d2-L3000-02

Exemestane C1(C=C[C@@]2([C@@]3(CC[C@]4d3-L3000-02

Irinotecan N1(CCCCC1)C2CCN(CC2)C(=O)d4-L3000-02

Cladribine N1=C(C2=C(N=C1Cl)N(C=N2)[C d5-L3000-02

Decitabine [C@H]1(O[C@@H]([C@H](C1)Od6-L3000-02

Dimesna S(CCSSCCS([O-])(=O)=O)([O-])(=d7-L3000-02

PIK-75 C1(C(=CN2C(C=1)=NC=C2/C=N/N(d8-L3000-02

Tivozanib (AV-951) C1(=CC=C(C(=C1)Cl)NC(=O)N d9-L3000-02

Doxorubicin (Adriamycin) C1(=CC=C2C(=C1OC)C(C3=C(C2d10-L3000-02

Adrucil (Fluorouracil) C1(NC(C(=CN1)F)=O)=O d11-L3000-02

Abitrexate (Methotrexate) N1=C(N=C2C(=C1N)N=C(C=N2)e1-L3000-02

Imiquimod N1=C2C(=C3C(=C1N)N=CN3CC(e2-L3000-02

Bendamustine HCL C1(=C(C=C2C(=C1)N(C(=N2)CCCe3-L3000-02

Nelarabine (Arranon) N1C(=NC2=C(C=1OC)N=CN2[C@e4-L3000-02

Bleomycin sulfate S(=O)(=O)(O)[O-].[C@H](C(C e5-L3000-02

Carboplatin [Pt+2].[O-]C(C1(C([O-])=O)CCC1e6-L3000-02

Clafen (Cyclophosphamide) C1COP(NC1)(=O)N(CCCl)CCCl e7-L3000-02

Clofarabine N1=C(N=C2C(=C1N)N=CN2[C@H]e8-L3000-02

YM201636 C1C(=CC=C(N=1)N)C(=O)NC2Ce9-L3000-02

OSI-930 C1=CC=C2C(=C1)C(=CC=N2)CNe10-L3000-02

Dacarbazine (DTIC-Dome) C1=NC(=C(N1)/N=N/N(C)C)C(=Oe11-L3000-02

Epirubicin HCl C1(=CC=C2C(=C1OC)C(C3=C(C2f1-L3000-02

Oxaliplatin (Eloxatin) [Pt+2].[O-]C(C([O-])=O)=O.C1 f2-L3000-02

Etoposide (VP-16) [C@@]12([C@@]([C@@H](C3=C(f3-L3000-02

Ku-0063794 N1=C(N=C2C(=C1N3CCOCC3)C=f4-L3000-02

Evista (Raloxifene HCl) C1(C=CC2=C(C=1)SC(=C2C(C3 f5-L3000-02

Idarubicin HCl C1(=CC=C2C(=C1)C(C3=C(C2=Of6-L3000-02

Fludarabine Phosphate (Fludara) N1C(=NC2=C(C=1N)N=CN2[C@H]f7-L3000-02

Topotecan HCl C1(C=CC2C(C=1CN(C)C)=CC3=Cf8-L3000-02

2-Methoxyestradiol C1(=C(C=C2C(=C1)[C@]3([C@@](f9-L3000-02

Letrozole C1=CC(=CC=C1C(N2N=CN=C2)f10-L3000-02

Leucovorin Calcium N1(=C(NC2=C(C1=O)N(C(CN2)CNf11-L3000-02

Temozolomide N1(N=NC2N(C1=O)C=NC=2C(N)g1-L3000-02

Vincristine C1(=CC2=C(C=C1[C@@]3(C4=C(g2-L3000-02

Amuvatinib (MP-470) C1=CC=C2C(=C1)C3=C(O2)C(= g3-L3000-02

Vinblastine C123[C@]4(N(CC1)CC=C[C@@]4g4-L3000-02

JNJ-7706621 C1(=CC=C(C=C1)NC2N=C(N(N=2g5-L3000-02

MDV3100 (Enzalutamide) C1(=C(C=CC(=C1)N2C(N(C(C2(Cg6-L3000-02

Celecoxib C1(=CC=C(C=C1)S(N)(=O)=O)N2g7-L3000-02

PD173074 N1=C(N=C2C(=C1)C=C(C(=N2) g8-L3000-02

WYE-354 C1=C(C=CC(=C1)C2=NC3=C(C(g9-L3000-02

Vemurafenib (PLX4032) C1(=CN=C2C(=C1)C(=CN2)C(=Og10-L3000-02

IC-87114 C12=C(N=C(N(C1=O)C3=C(C= g11-L3000-02

BX-795 N1(CCCC1)C(=O)NC2C=C(C=CCh1-L3000-02

Altretamine (Hexalen) N1=C(N=C(N=C1N(C)C)N(C)C)Nh2-L3000-02

Carmofur C1(C(NC(N(C=1)C(NCCCCCC)=Oh3-L3000-02

Epothilone A O1[C@@H]2CCC[C@@H]([C@@H](h4-L3000-02

Floxuridine (Fludara) O1[C@@H]([C@H](C[C@H]1N2Ch5-L3000-02

Ftorafur N1C(N(C=C(C1=O)F)[C@@H]2Oh6-L3000-02

Ifosfamide C1COP(N(C1)CCCl)(NCCCl)=O h7-L3000-02

Megestrol Acetate C1C(C=C2[C@](C1)([C@]3([C@@]h8-L3000-02

Mercaptopurine N1=CNC2=C(C1=S)NC=N2 h9-L3000-02

Pamidronate Disodium C(O)(P([O-])(O)=O)(CCN)P([O-])(h10-L3000-02

Streptozotocin (Zanosar) [C@H]1([C@@H]([C@H]([C@@H]h11-L3000-02

Dexamethasone C1C(C=C2[C@](C=1)([C@]3([C@a1-L3000-03

Rigosertib (ON-01910) C1(=C(C=C(C=C1OC)OC)OC)/C=Ca2-L3000-03

Epothilone B (EPO906) O1[C@@]2(CCC[C@@H]([C@@H](a3-L3000-03

Dorzolamide HCl C1([C@@H](S(C2=C([C@@H]1NCa4-L3000-03

Ruxolitinib (INCB018424) N1=CN=C2C(=C1C3=CN(N=C3) a5-L3000-03

Isotretinoin C(/C=C(\C=C\C=C(/C=C/C1=C(Ca6-L3000-03

Pelitinib (EKB-569) C1(=C(C=C2C(=C1)N=CC(=C2NCa7-L3000-03

Zileuton C1=CC=C2C(=C1)SC(=C2)C(N(Oa8-L3000-03

Ispinesib (SB-715992) C1=CC(=CC=C1)CN2C(C3=C(N=Ca9-L3000-03

Tipifarnib (Zarnestra) C1=CC(=CC=C1[C@](C2=CN=CN2a10-L3000-03

Zibotentan (ZD4054) C1(C(=CC=CN=1)S(=O)(=O)NC a11-L3000-03

Doxercalciferol (Hectorol) C1[C@@H](C(/C(C[C@@H]1O)=C/b1-L3000-03

SB 525334 C1(=CC=C2C(=C1)N=CC=N2)C3b2-L3000-03

AEE788 (NVP-AEE788) C1=NC(=C2C(=N1)NC(=C2)C3= b3-L3000-03

PHA-793887 N1N=C(C2=C1C(N(C2)C(C3CCN(b4-L3000-03

PIK-93 C1(=C(C=C(C=C1)C2SC(=NC=2Cb5-L3000-03

Ponatinib (AP24534) C1C=NN2C(C=1)=NC=C2C#CC3=b6-L3000-03

Fludarabine (Fludara) O1[C@@H]([C@H]([C@@H]([C@b7-L3000-03

LY2228820 CC(C1=NC(=C(N1)C2=NC3=C(C=b8-L3000-03

Mycophenolate mofetil (CellCept) C12=C(C(=C(C(=C1O)C/C=C(/ b9-L3000-03

SB939 (Pracinostat) C1(=CC=C2C(=C1)N=C(N2CCN(b10-L3000-03

Tosedostat (CHR2797) [C@@H]([C@@H](C(=O)NO)O)(b11-L3000-03

XL765 (SAR245409) C12=CC=CC=C1N=C(C(=N2)NC3c1-L3000-03

AT7519 C1=C(C(=C(C=C1)Cl)C(NC2=C c2-L3000-03

MK-1775 C1=CC(=NC(=C1)C(O)(C)C)N2 c3-L3000-03

Quizartinib (AC220) C1=C(C=CC(=C1)C2N=C3N(C=2c4-L3000-03

AZD7762 C1(=CC=CC(=C1)C2SC(=C(C=2 c5-L3000-03

R406 (free base) C1(=C(C=C(C=C1OC)NC2=NC(=c6-L3000-03

DMXAA (ASA404) C12=C(C(=CC=C1)CC(O)=O)OCc7-L3000-03

EX 527 N1C2=C(C3=C1C=CC(=C3)Cl)C c8-L3000-03

Febuxostat (Uloric) C1(=C(C=CC(=C1)C2SC(=C(N=2c9-L3000-03

Dapagliflozin C1(=CC=C(C(=C1)CC2=CC=C(Cc10-L3000-03

AZD8055 C1(=C(C=CC(=C1)C2=NC3=C(Cc11-L3000-03

BMS 777607 C1(=C(N=CC=C1OC2=CC=C(C=Cd1-L3000-03

Pomalidomide C1=CC=C2C(=C1N)C(N(C2=O)Cd2-L3000-03

KU-60019 C1=C(C=CC2=C1CC3=C(S2)C(=d3-L3000-03

BIRB 796 (Doramapimod) C1=C(C2=C(C(=C1)OCCN3CCOCd4-L3000-03

Tie2 kinase inhibitor C12=C(C=CC(=C1)C3=C(N=C(Nd5-L3000-03

Ubenimex (Bestatin) C1=CC=CC(=C1)C[C@H]([C@@H]d6-L3000-03

Prednisone (Adasone) C1C(C=C2[C@](C=1)([C@]3([C@@d7-L3000-03

Triamcinolone Acetonide C1C(C=C2[C@](C=1)([C@]3([C@d8-L3000-03

Cytarabine C1(N(C=CC(=N1)N)[C@@H]2O[ d9-L3000-03

Tretinoin (Aberela) C1CCC(=C(C1(C)C)/C=C/C(=C/Cd10-L3000-03

Ezetimibe (Zetia) C1=C(C=CC(=C1)[C@H](CC[C@d11-L3000-03

Estrone C1=C(C=C2C(=C1)[C@]3([C@@](Ce1-L3000-03

Aminoglutethimide (Cytadren) C1(=CC=C(C=C1)N)C2(CCC(NCe2-L3000-03

Disulfiram (Antabuse) CCN(C(SSC(N(CC)CC)=S)=S)CCe3-L3000-03

Betapar (Meprednisone) C1C(C=C2[C@](C=1)([C@]3([C@@e4-L3000-03

Busulfan (Myleran, Busulfex) CS(OCCCCOS(C)(=O)=O)(=O)= e5-L3000-03

Hydrocortisone (Cortisol) C1C(C=C2[C@](C1)([C@]3([C@@]e6-L3000-03

Estradiol C1C(=CC2=C(C=1)[C@]3([C@@](Ce7-L3000-03

Gemcitabine (Gemzar) N1=C(C=CN(C1=O)[C@@H]2O[Ce8-L3000-03

Azathioprine (Azasan, Imuran) N1=CN=C2C(=C1SC3=C(N=CN3C)e9-L3000-03

Mesna (Uromitexan, Mesnex) SCCS([O-])(=O)=O.[Na+] e10-L3000-03

Toremifene Citrate (Fareston, AcapodeneC1(=C(C=CC(=C1)/C(C2=CC=CCe11-L3000-03

Azacitidine (Vidaza) [C@H]1([C@H](O[C@H]([C@H]1f1-L3000-03

Teniposide (Vumon) C1=C2C(=CC3=C1OCO3)[C@@H]f2-L3000-03

Simvastatin (Zocor) C1[C@H](C=C2[C@]([C@@H]1OCf3-L3000-03

Ranolazine (Ranexa) C1=CC=C(C(=C1C)NC(CN2CCNf4-L3000-03

Lomustine (CeeNU) C1CCCC(C1)NC(N(CCCl)N=O)= f5-L3000-03

D-glutamine NC(CC[C@H](C(=O)O)N)=O f6-L3000-03

Hydroxyurea (Cytodrox) N(C(N)=O)O f7-L3000-03

Flutamide (Eulexin) C1(=C(C=C(C=C1)NC(C(C)C)=O)C(f8-L3000-03

Fluvastatin sodium (Lescol) C12(=C(C=CC=C1)N(C(=C2C3=CCf9-L3000-03

Tamoxifen Citrate (Nolvadex) C1(=CC=C(C=C1)/C(=C(/CC)C2 f10-L3000-03

Procarbazine HCl (Matulane) C1(=CC=C(C=C1)CNNC)C(NC(C)f11-L3000-03

Sodium butyrate CCCC([O-])=O.[Na+] g1-L3000-03

Maraviroc C1=CC=CC(=C1)[C@H](CCN2C3g2-L3000-03

PF 573228 N1C(CCC2C=C(C=CC1=2)NC3N=Cg3-L3000-03

Cyclophosphamide monohydrate C1(CNP(OC1)(=O)N(CCCl)CCCl)g4-L3000-03

Bexarotene C12=C(C=C(C(=C1)C)C(C3=CC=g5-L3000-03

Vinpocetine (Cavinton) C1=CC=C2C(=C1)C3=C4N2C(=Cg6-L3000-03

Lapatinib C1=C(C=C2C(=C1)N=CN=C2NC3g7-L3000-03

Neratinib (HKI-272) C1(=C(C=C2C(=C1)N=CC(=C2Ng8-L3000-03

LDE225 (NVP-LDE225, Erismodegib) C1(=CC=C(N=C1)N2C[C@@H](Og9-L3000-03

AG14361 C12=C3C=CC=C1N=C(N2CCNC3g10-L3000-03

MLN2238 C1=CC(=CC(=C1Cl)C(NCC(N[C@g11-L3000-03

MLN9708 C1=CC(=CC(=C1Cl)C(NCC(N[C@h1-L3000-03

SB 743921 C1(=CC(=CC=C1)CC2C(C3=C(OCh2-L3000-03

GSK461364 C1N(CCN(C1)CC2=CC3=C(C=C2h3-L3000-03

SGI-1776 free base C1C(=NN2C(C=1)=NC=C2C3=CCh4-L3000-03

BMS 794833 N1=C(C(=C(C=C1)OC2=CC=C(Ch5-L3000-03

OSI-420 C1(=C(C=CC=C1NC2=NC=NC3=Ch6-L3000-03

R935788 (Fostamatinib disodium, R788 dC1(=C(C(=CC(=C1)NC2=NC=C(C(h7-L3000-03

Formestane C1C(C(=C2[C@](C1)([C@]3([C@@h8-L3000-03

DAPT (GSI-IX) C1(=CC(=CC(=C1)CC(=O)N[C@@h9-L3000-03

Irinotecan HCl Trihydrate (Campto) C1(CCN(CC1)C2CCN(CC2)C(OC3h10-L3000-03

Cyt387 C1=C(C=CC(=C1)NC2=NC=CC( h11-L3000-03

SB590885 N1C(=C(NC=1C2=CC=C(C=C2)Oa1-L3000-04

TAME C1=C(C=CC(=C1)S(N[C@H](C(Oa2-L3000-04

CAL-101 (GS-1101) C1=CC=C2C(=C1F)C(N(C(=N2) a3-L3000-04

LY2157299 C1(=CC=CC(=N1)C2=NN3C(=C(a4-L3000-04

Telatinib (BAY 57-9352) N1=C(C2=C(C(=N1)OCC3=CC(=a5-L3000-04

BI6727 (Volasertib) [C@H]1(C(N(C2=C(N1C(C)C)N a6-L3000-04

Palomid 529 C1=C(C=CC(=C1)COC2=C(C=C3a7-L3000-04

WP1130 C1(=CC=CC(=N1)/C=C(/C(N[C@a8-L3000-04

AR-42 (HDAC-42) C1=CC=C(C=C1)[C@@H](C(NC2a9-L3000-04

CP-466722 C1=CC=CN=C1C2=NN(C(=N2)N)a10-L3000-04

BKM120 (NVP-BKM120) C1=C(N=CC(=C1C(F)(F)F)C2= a11-L3000-04

CX-4945 (Silmitasertib) C1=NC=C2C(=C1)C(=NC3=C2C=b1-L3000-04

(-)-Epigallocatechin gallate C1(=C(C(=CC(=C1)C(O[C@H]2[ b2-L3000-04

Cyclosporin A (Cyclosporine A) N1(C(=O)[C@@H](N(C(=O)[C@Hb3-L3000-04

Gossypol C1(=C(C(=C(C2=C1C(=C(C(=C2 b4-L3000-04

Phloretin (Dihydronaringenin) C1(=CC(=C(C(=C1)O)C(CCC2=Cb5-L3000-04

Salinomycin (Procoxacin) C1[C@H]([C@@]2(O[C@@]([C@@b6-L3000-04

Quercetin (Sophoretin) C1(=CC(=C2C(=C1)OC(=C(C2=Ob7-L3000-04

Coenzyme Q10 (CoQ10) C1(=C(C(C(=C(C1=O)C/C=C(/CCb8-L3000-04

Chrysophanic acid (Chrysophanol) C1=CC(=C2C(=C1)C(C3=C(C2=Ob9-L3000-04

Imatinib (Gleevec) N1=C(N=C(C=C1)C2=CC=CN=Cb10-L3000-04

Itraconazole (Sporanox) C1=CC(=CC=C1N2CCN(CC2)C3=b11-L3000-04

Mitoxantrone HCl C1(=CC(=C2C(=C1O)C(C3=C(C c1-L3000-04

Mycophenolic (Mycophenolate) C12=C(C(=C(C(=C1O)C/C=C(\C c2-L3000-04

Rosiglitazone (Avandia) C1=CC=NC(=C1)N(CCOC2=CC=c3-L3000-04

Medroxyprogesterone acetate C1C(C=C2[C@](C1)([C@]3([C@@c4-L3000-04

Pioglitazone (Actos) C1(=CC=C(N=C1)CCOC2=CC=C(c5-L3000-04

Mifepristone (Mifeprex) C1C(C=C2C(C1)=C3[C@@](CC2)(c6-L3000-04

Lonidamine C1=CC=C2C(=C1)N(N=C2C(O)=Oc7-L3000-04

TAK-733 N1(C=NC2=C(C1=O)C(=C(C(N2 c8-L3000-04

LDN193189 C1(=CC=C(C=C1)C2C=NC3N(C c9-L3000-04

LY2603618 (IC-83) C1=C(C(=CC(=C1OC[C@@H]2CNc10-L3000-04

GW3965 HCl C1(=C(C=C(C=C1)OCCCN(CC2=Cc11-L3000-04

DCC-2036 (Rebastinib) C1(=C(C=C(C=C1)OC2=CC(=NC=d1-L3000-04

NU7441 (KU-57788) C1=C(OC2=C(C1=O)C=CC=C2Cd2-L3000-04

GSK2126458 C1(C(=CC(=CC=1)F)F)S(=O)(= d3-L3000-04

MK-0752 C1=CC(=CC=C1Cl)S([C@]2(CC[ d4-L3000-04

PF-3845 C1(=CN=C(C=C1)OC2=CC(=CC=d5-L3000-04

GSK1120212 (Trametinib) C1(N(C(=C2C(=C1C)N(C(N(C2= d6-L3000-04

Flavopiridol (Alvocidib) HCl C1(=C(C(=C2C(=C1O)C(C=C(O2)d7-L3000-04

PCI-32765 (Ibrutinib) C1=NC(=C2C(=N1)N(N=C2C3=Cd8-L3000-04

NVP-BSK805 2HCl C1(=CC=C2C(=C1C3=CC(=C(C(=d9-L3000-04

WAY-362450 C1=CC=C2C(=C1)C3=C(N2)C(=Cd10-L3000-04

A-769662 C1(=CC=C(C=C1)C2=CSC3=C2Cd11-L3000-04

CH5132799 N1=C(N=CC(=C1)C2=C3C(=NC(=e1-L3000-04

KX2-391 C1=C(C=CC(=C1)C2=CC=C(N= e2-L3000-04

LY2109761 C12=C(C=C(C=C1)OCCN3CCOCe3-L3000-04

YO-01027 C1(=CC(=CC(=C1)CC(N[C@H](Ce4-L3000-04

Geldanamycin C1(C(C=C2NC(/C(=C/C=C/[C@@e5-L3000-04

AMG 900 C1=CC(=C(N=C1)OC2=CC=C(C=e6-L3000-04

PF-03814735 C12=C(C=C(C=C1)NC3=NC(=C(e7-L3000-04

PH-797804 C1(=C(C=CC(=C1)C(=O)NC)C)Ne8-L3000-04

Dacomitinib (PF299804,PF-00299804) C(/C=C/C(NC1=C(C=C2C(=C1)Ce9-L3000-04

Crenolanib (CP-868596) C1=CC(=C2C(=C1)C=CC(=N2)Ne10-L3000-04

AZ 3146 C1(=CC(=C(C=C1)NC2=NC3=C(e11-L3000-04

TG101348 (SAR302503) C1(=CC=C(C=C1)NC2=NC(=C(Cf1-L3000-04

PAC-1 C1(CN2CCN(CC2)CC(N/N=C/C3f2-L3000-04

AZ628 C1(=CC=CC(=C1)C(NC2=CC=C(Cf3-L3000-04

AT-406 C1=CC(=CC=C1)C(C2=CC=CC=Cf4-L3000-04

Canagliflozin [C@H]1([C@H]([C@@H]([C@H] f5-L3000-04

3-Methyladenine N1=CN=C2N(C=NC(=C12)N)C f6-L3000-04

Dalcetrapib (JTT-705) C1=CC=CC(=C1NC(C2(CCCCC2)f7-L3000-04

Nocodazole C(NC1=NC2C(N1)=CC(=CC=2)Cf8-L3000-04

GW4064 C1=CC=C(C=C1C(=O)O)/C=C/C2f9-L3000-04

Tofacitinib (CP-690550, Tasocitinib) N1=CN=C2C(=C1N(C)[C@H]3C f10-L3000-04

Sotrastaurin (AEB071) N1C(C(=C(C1=O)C2N=C(N=C3 f11-L3000-04

APO866 (FK866) C(/C=C/C1C=NC=CC=1)(=O)NC g1-L3000-04

Sirtinol C(C1C(=CC=CC=1)/N=C/C2C(= g2-L3000-04

CEP33779 C1(=CC=CC(=C1)NC2N=C3N(N=g3-L3000-04

INK 128 (MLN0128) N1=CN=C2C(=C1N)C(=NN2C(C)g4-L3000-04

Torin 2 N1(C(C=CC2C=NC3C(C1=2)=CC(g5-L3000-04

RG108 [C@@](N1C(C2=CC=CC=C2C1=Og6-L3000-04

TPCA-1 C1(=C(C=C(S1)C2C=CC(=CC=2)g7-L3000-04

Desmethyl Erlotinib (CP-473420) C1=C(C=CC=C1NC2=NC=NC3=Cg8-L3000-04

Torin 1 N1(C(C=CC2C=NC3C(C1=2)=CC(g9-L3000-04

PF-562271 C1=NC(=C(C=C1)CNC2=C(C=NC(g10-L3000-04

S-Ruxolitinib N1C2=C(C(=NC=1)C3=CN(N=C3g11-L3000-04

BAY 11-7082 (BAY 11-7821) C1(S(/C=C/C#N)(=O)=O)C=CC(=h1-L3000-04

CHIR-99021 (CT99021) HCl C1(=NC=C(C(=N1)C2=CC=C(C=Ch2-L3000-04

Pazopanib C1(C(=CC=C(C=1)NC2N=C(C=CNh3-L3000-04

Daunorubicin HCl (Daunomycin HCl) C1(=CC=C2C(=C1OC)C(C3=C(C2h4-L3000-04

Dexamethasone acetate C1C(C=C2[C@](C=1)([C@]3([C@h5-L3000-04

Anagrelide HCl C1(=C(C(=C2C(=C1)NC3N(C2)CC(h6-L3000-04

Triptolide [C@@]123[C@@]4([C@@H](C[Ch7-L3000-04

Fingolimod (FTY720) C1(=CC=C(C=C1)CCCCCCCC)CCh8-L3000-04

CAS Number Concentmolecular wCatalog Target923564-51-6 10 mM 974.61 S1001 Bcl-2

852808-04-9 10 mM 813.43 S1002 Autophagy

796967-16-3 10 mM 375.41 S1003 CSF-1R

912444-00-9 10 mM 244.29 S1004 PARP

319460-85-0 10 mM 386.47 S1005 c-Kit

379231-04-6 10 mM 542.03 S1006 Bcr-Abl

606143-52-6 10 mM 457.68 S1008 MEK

915019-65-7 10 mM 469.55 S1009 ATM/ATR

656247-17-5 10 mM 539.62 S1010 FGFR

439081-18-2 10 mM 485.94 S1011 EGFR

179324-69-7 10 mM 384.24 S1013 Proteasome

380843-75-4 10 mM 530.45 S1014 Src

288383-20-0 10 mM 450.51 S1017 VEGFR

405169-16-6 10 mM 392.43 S1018 c-Kit

212631-79-3 10 mM 478.67 S1020 MEK

302962-49-8 10 mM 488.01 S1021 Bcr-Abl

572924-54-0 10 mM 990.21 S1022 mTOR

183319-69-9 10 mM 429.90 S1023 Autophagy

184475-35-2 10 mM 446.90 S1025 EGFR

220127-57-1 10 mM 589.71 S1026 Bcr-Abl

388082-77-7 10 mM 925.46 S1028 EGFR

191732-72-6 10 mM 259.26 S1029 TNF-alpha

857876-30-3 10 mM 569.44 S1032 c-Kit

641571-10-0 10 mM 529.52 S1033 Bcr-Abl

391210-10-9 10 mM 482.19 S1036 MEK

371935-74-9 10 mM 348.36 S1038 Autophagy

53123-88-9 10 mM 914.18 S1039 Autophagy

475207-59-1 10 mM 637.03 S1040 PDGFR

315702-99-9 10 mM 267.35 S1041

341031-54-7 10 mM 532.56 S1042 c-Kit

387867-13-2 10 mM 562.70 S1043 FLT3

162635-04-3 10 mM 1030.29 S1044 mTOR

58880-19-6 10 mM 302.40 S1045 HDAC

443913-73-3 10 mM 475.35 S1046 VEGFR

149647-78-9 10 mM 264.30 S1047 Autophagy

639089-54-6 10 mM 464.59 S1048 Aurora Kinase

129830-38-2 10 mM 320.26 S1049 Autophagy

488832-69-5 10 mM 400.50 S1052 HSP (e.g. HSP90)

209783-80-2 10 mM 376.41 S1053 HDAC

170364-57-5 10 mM 515.61 S1055 PKC

714971-09-2 10 mM 567.01 S1056 EGFR

803712-79-0 10 mM 413.49 S1057 Autophagy

763113-22-0 10 mM 434.46 S1060 PARP

890090-75-2 10 mM 581.50 S1061 E3 Ligase

790299-79-5 10 mM 498.64 S1064 c-Kit

957054-30-7 10 mM 513.64 S1065 PI3K

301836-41-9 10 mM 384.39 S1067 TGF-beta/Smad

877399-52-5 10 mM 450.34 S1068 ALK

747412-49-3 10 mM 465.54 S1069 HSP (e.g. HSP90)

477575-56-7 10 mM 641.61 S1070 c-Met

475110-96-4 10 mM 417.41 S1072 PI3K

280744-09-4 10 mM 371.22 S1075 GSK-3

152121-47-6 10 mM 377.43 S1076 p38 MAPK

1032350-13-2 10 mM 480.39 S1078 Akt

183322-45-4 10 mM 396.67 S1079 EGFR

658084-23-2 10 mM 568.09 S1080 c-Met

879085-55-9 10 mM 421.30 S1082 Hedgehog

649735-46-6 10 mM 370.38 S1084 FGFR

414864-00-9 10 mM 318.35 S1085 HDAC

160003-66-7 10 mM 292.03 S1087 PARP

783355-60-2 10 mM 397.42 S1090 HDAC

867160-71-2 10 mM 421.49 S1091 IGF-1R

587871-26-9 10 mM 395.49 S1092 ATM/ATR

1089283-49-7 10 mM 851.96 S1093 IGF-1R

956905-27-4 10 mM 372.38 S1094 c-Met

875320-29-9 10 mM 394.48 S1096 HDAC

957217-65-1 10 mM 431.39 S1097

459868-92-9 10 mM 421.36 S1098 PARP

212141-51-0 10 mM 419.73 S1101 c-Kit

905281-76-7 10 mM 334.37 S1104 Raf

154447-36-6 10 mM 307.34 S1105 Autophagy


761439-42-3 10 mM 614.20 S1108 ALK

755038-02-9 10 mM 521.66 S1109 PLK

1022150-57-7 10 mM 359.41 S1112 c-Met

937174-76-0 10 mM 425.48 S1113 Akt

943540-75-8 10 mM 377.35 S1114 c-Met

827022-32-2 10 mM 483.99 S1116 CDK

35943-35-2 10 mM 320.30 S1117 Akt

956958-53-5 10 mM 448.52 S1118 PI3K

159351-69-6 10 mM 958.22 S1120 mTOR

877877-35-5 10 mM 573.70 S1121 Bcl-2

726169-73-9 10 mM 396.44 S1122 HDAC

154229-19-3 10 mM 349.51 S1123 P450 (e.g. CYP17

1001645-58-4 10 mM 506.02 S1129 Sirtuin

781661-94-7 10 mM 443.29 S1130 E3 Ligase



150399-23-8 10 mM 471.37 S1135 DHFR

401900-40-1 10 mM 441.36 S1140 Androgen Recepto

75747-14-7 10 mM 585.69 S1141 HSP (e.g. HSP90)

467214-21-7 10 mM 653.21 S1142 HSP (e.g. HSP90)

345627-80-7 10 mM 380.53 S1145 CDK

4449-51-8 10 mM 411.62 S1146 Hedgehog


114977-28-5 10 mM 807.88 S1148 Microtubule Assoc

122111-03-9 10 mM 299.66 S1149 Autophagy

33069-62-4 10 mM 853.91 S1150 Autophagy

186692-46-6 10 mM 354.45 S1153 CDK


154361-50-9 10 mM 359.35 S1156 DNA/RNA Synthes

888216-25-9 10 mM 364.40 S1159 HSP (e.g. HSP90)

417716-92-8 10 mM 426.85 S1164 VEGFR



1069-66-5 10 mM 166.19 S1168 Autophagy


881202-45-5 10 mM 328.41 S1172 E3 Ligase

1213269-23-8 10 mM 494.18 S1173 EGFR


848695-25-0 10 mM 318.76 S1175 HSP (e.g. HSP90)

755037-03-7 10 mM 482.82 S1178 c-Kit

284028-89-3 10 mM 312.31 S1180 Wnt/beta-catenin


321674-73-1 10 mM 331.36 S1186 Telomerase

677338-12-4 10 mM 351.36 S1187 PI3K

120511-73-1 10 mM 293.37 S1188 Aromatase

170729-80-3 10 mM 534.43 S1189 Substance P


129453-61-8 10 mM 606.77 S1191 Estrogen/progest


50-35-1 10 mM 258.23 S1193 E3 Ligase

1012054-59-9 10 mM 434.49 S1194 EGFR

107868-30-4 10 mM 296.40 S1196 Aromatase

97682-44-5 10 mM 586.68 S1198 Topoisomerase


2353-33-5 10 mM 228.21 S1200 DNA Methyltransf

16208-51-8 10 mM 326.34 S1201

372196-77-5 10 mM 488.74 S1205 DNA-PK

475108-18-0 10 mM 454.86 S1207 c-Kit

25316-40-9 10 mM 579.98 S1208 Autophagy


59-05-2 10 mM 454.44 S1210 DHFR

99011-02-6 10 mM 240.30 S1211

3543-75-7 10 mM 394.72 S1212






371942-69-7 10 mM 467.48 S1219 PI3K

728033-96-3 10 mM 443.44 S1220 c-Kit





938440-64-3 10 mM 465.54 S1226 mTOR





362-07-2 10 mM 302.41 S1233 HIF

112809-51-5 10 mM 285.30 S1235 Aromatase

6035-45-6 10 mM 601.58 S1236

85622-93-1 10 mM 194.15 S1237 Autophagy

2068-78-2 10 mM 923.04 S1241 Autophagy

850879-09-3 10 mM 447.51 S1244 c-Kit

57-22-7 10 mM 824.96 S1248 AChR



169590-42-5 10 mM 381.37 S1261 COX

219580-11-7 10 mM 523.67 S1264 FGFR

1062169-56-5 10 mM 495.53 S1266 mTOR

918504-65-1 10 mM 489.92 S1267 Raf

371242-69-2 10 mM 397.43 S1268 PI3K

702675-74-9 10 mM 591.47 S1274 IκB/IKK

645-05-6 10 mM 210.28 S1278








57248-88-1 10 mM 279.03 S1311

18883-66-4 10 mM 265.22 S1312

50-02-2 10 mM 392.46 S1322 Autophagy

1225497-78-8 10 mM 473.47 S1362 PLK


130693-82-2 10 mM 360.90 S1375 Carbonic Anhydra

941678-49-5 10 mM 306.37 S1378 JAK

4759-48-2 10 mM 300.44 S1379 Hydroxylase

257933-82-7 10 mM 467.92 S1392 EGFR

111406-87-2 10 mM 236.29 S1443

336113-53-2 10 mM 517.06 S1452 Kinesin

192185-72-1 10 mM 489.40 S1453 Transferase

186497-07-4 10 mM 424.43 S1456 Endothelin Recept

54573-75-0 10 mM 412.65 S1467

356559-20-1 10 mM 343.42 S1476 TGF-beta/Smad

497839-62-0 10 mM 440.58 S1486 EGFR

718630-59-2 10 mM 361.48 S1487 CDK

593960-11-3 10 mM 389.88 S1489 PI3K

943319-70-8 10 mM 532.56 S1490 Bcr-Abl


862507-23-1 10 mM 612.74 S1494 p38 MAPK

128794-94-5 10 mM 433.49 S1501 Dehydrogenase

929016-96-6 10 mM 358.48 S1515 HDAC

238750-77-1 10 mM 406.47 S1522 Aminopeptidase

1349796-36-6 10 mM 599.66 S1523 mTOR

844442-38-2 10 mM 382.24 S1524 CDK

955365-80-7 10 mM 500.60 S1525 Wee1

950769-58-1 10 mM 560.67 S1526 FLT3

860352-01-8 10 mM 362.42 S1532 Chk

841290-80-0 10 mM 470.45 S1533 Syk

117570-53-3 10 mM 282.29 S1537 VDA

49843-98-3 10 mM 248.71 S1541 Sirtuin

144060-53-7 10 mM 316.37 S1547

461432-26-8 10 mM 408.87 S1548 SGLT

1009298-09-2 10 mM 465.54 S1555 mTOR

1025720-94-8 10 mM 512.89 S1561 Axl

19171-19-8 10 mM 273.24 S1567 TNF-alpha

925701-49-1 10 mM 547.67 S1570 ATM/ATR

285983-48-4 10 mM 527.66 S1574 p38 MAPK

948557-43-5 10 mM 439.53 S1577 Tie-2

58970-76-6 10 mM 308.37 S1591

53-03-2 10 mM 358.43 S1622

76-25-5 10 mM 434.50 S1628


302-79-4 10 mM 300.40 S1653

163222-33-1 10 mM 409.40 S1655


125-84-8 10 mM 232.28 S1672 Aromatase

97-77-8 10 mM 296.54 S1680

1247-42-3 10 mM 372.46 S1689

55-98-1 10 mM 246.30 S1692

50-23-7 10 mM 362.46 S1696

50-28-2 10 mM 272.38 S1709

95058-81-4 10 mM 263.20 S1714 Autophagy

446-86-6 10 mM 277.26 S1721

19767-45-4 10 mM 164.18 S1735



29767-20-2 10 mM 656.65 S1787

79902-63-9 10 mM 418.57 S1792

95635-55-5 10 mM 427.54 S1799

13010-47-4 10 mM 233.70 S1840

5959-95-5 10 mM 146.14 S1893

127-07-1 10 mM 76.05 S1896

13311-84-7 10 mM 276.21 S1908 P450 (e.g. CYP17

93957-55-2 10 mM 433.45 S1909 HMG-CoA Reduct

54965-24-1 10 mM 563.64 S1972 Autophagy


156-54-7 10 mM 110.09 S1999

376348-65-1 10 mM 513.67 S2003 CCR5

869288-64-2 10 mM 491.49 S2013 FAK

6055-19-2 10 mM 279.10 S2057

153559-49-0 10 mM 348.00 S2098

42971-09-5 10 mM 350.45 S2110 Sodium Channel

231277-92-2 10 mM 581.06 S2111 EGFR

698387-09-6 10 mM 557.04 S2150 EGFR

956697-53-3 10 mM 485.50 S2151 Smoothened

328543-09-5 10 mM 320.39 S2178 PARP

1072833-77-2 10 mM 361.03 S2180 Proteasome

1201902-80-8 10 mM 517.12 S2181 Proteasome

940929-33-9 10 mM 553.52 S2182 Kinesin

929095-18-1 10 mM 543.60 S2193 PLK

1025065-69-3 10 mM 405.42 S2198 Pim

1174046-72-0 10 mM 468.84 S2201 c-Met

183320-51-6 10 mM 415.87 S2205 EGFR

1025687-58-4 10 mM 624.42 S2206 Syk

566-48-3 10 mM 302.41 S2208 Aromatase

208255-80-5 10 mM 432.46 S2215 Beta Amyloid


1056634-68-4 10 mM 414.46 S2219 JAK

405554-55-4 10 mM 453.54 S2220 Raf

901-47-3 10 mM 342.41 S2225 APC

870281-82-6 10 mM 415.42 S2226 PI3K

700874-72-2 10 mM 369.42 S2230 TGF-beta/Smad

332012-40-5 10 mM 409.83 S2231 c-Kit

755038-65-4 10 mM 618.81 S2235 PLK

914913-88-5 10 mM 406.43 S2238 mTOR

856243-80-6 10 mM 384.27 S2243 Bcr-Abl

935881-37-1 10 mM 312.36 S2244 HDAC

1080622-86-1 10 mM 349.35 S2245 ATM/ATR

944396-07-0 10 mM 410.39 S2247 PI3K

1009820-21-6 10 mM 349.77 S2248 PKC

989-51-5 10 mM 458.37 S2250

59865-13-3 10 mM 1202.61 S2286

303-45-7 10 mM 518.56 S2303

60-82-2 10 mM 274.27 S2342

53003-10-4 10 mM 751.00 S2352

117-39-5 10 mM 302.24 S2391 PI3K

303-98-0 10 mM 863.34 S2398

481-74-3 10 mM 254.24 S2406 EGFR

152459-95-5 10 mM 493.60 S2475 PDGFR

84625-61-6 10 mM 705.65 S2476

70476-82-3 10 mM 517.40 S2485

24280-93-1 10 mM 320.34 S2487

122320-73-4 10 mM 357.43 S2556 PPAR


111025-46-8 10 mM 356.44 S2590


50264-69-2 10 mM 321.16 S2610

1035555-63-5 10 mM 504.23 S2617 MEK

1062368-24-4 10 mM 406.48 S2618 TGF-beta/Smad

911222-45-2 10 mM 436.30 S2626 Chk

405911-17-3 10 mM 618.51 S2630 Liver X Receptor

1020172-07-9 10 mM 553.59 S2634 Bcr-Abl

503468-95-9 10 mM 413.49 S2638 DNA-PK

1086062-66-9 10 mM 505.50 S2658 mTOR

471905-41-6 10 mM 442.90 S2660 Beta Amyloid

1196109-52-0 10 mM 456.46 S2666 FAAH

871700-17-3 10 mM 615.39 S2673 MEK

131740-09-5 10 mM 438.30 S2679 CDK

936563-96-1 10 mM 440.50 S2680 BTK

1092499-93-8 (free base) 10 mM 563.47 S2686 JAK

629664-81-9 10 mM 438.47 S2694 FXR

844499-71-4 10 mM 360.39 S2697 AMPK

1007207-67-1 10 mM 377.42 S2699 mTOR

897016-82-9 10 mM 431.53 S2700 Src

700874-71-1 10 mM 441.52 S2704 TGF-beta/Smad

209984-56-5 10 mM 463.48 S2711 Gamma-secretase

30562-34-6 10 mM 560.64 S2713 Autophagy



586379-66-0 10 mM 477.30 S2726 p38 MAPK

1110813-31-4 10 mM 469.94 S2727 EGFR

670220-88-9 10 mM 443.54 S2730 PDGFR

1124329-14-1 10 mM 452.55 S2731 Kinesin

936091-26-8 10 mM 524.68 S2736 JAK

315183-21-2 10 mM 392.49 S2738 Caspase

878739-06-1 10 mM 451.52 S2746 Raf

1071992-99-8 10 mM 561.71 S2754 E3 Ligase

842133-18-0 10 mM 444.52 S2760 SGLT

5142-23-4 10 mM 149.15 S2767 Autophagy

211513-37-0 10 mM 389.59 S2772 CETP

31430-18-9 10 mM 301.32 S2775 Autophagy

278779-30-9 10 mM 542.84 S2782 FXR

477600-75-2 10 mM 312.37 S2789 JAK

425637-18-9 10 mM 438.48 S2791 PKC

658084-64-1 10 mM 391.51 S2799

410536-97-9 10 mM 394.47 S2804 Sirtuin

1257704-57-6 10 mM 462.57 S2806 JAK

1224844-38-5 10 mM 309.33 S2811 mTOR

1223001-51-1 10 mM 432.40 S2817 ATM/ATR


507475-17-4 10 mM 279.29 S2824 IκB/IKK

183321-86-0 10 mM 379.41 S2826 EGFR

1222998-36-8 10 mM 607.62 S2827 Autophagy

717907-75-0 10 mM 507.49 S2890 FAK

941685-37-6 10 mM 306.37 S2902 JAK

19542-67-7 10 mM 207.25 S2913 E2 conjugating

252917-06-9 (free base) 10 mM 501.80 S2924 GSK-3

444731-52-6 10 mM 437.52 S3012 c-Kit

23541-50-6 10 mM 563.98 S3035 Telomerase

1177-87-3 10 mM 434.50 S3124

58579-51-4 10 mM 292.55 S3172 PDE

38748-32-2 10 mM 360.40 S3604

162359-56-0 10 mM 343.90 S5002 Bcr-Abl

DescriptionABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively.

Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.

ABT-888 (Veliparib, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.

Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.

Saracatinib (AZD0530) is a Src inhibitor for c-Src and v-Abl with IC50 of 2.7 nM and 30 nM, respectively.

AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM.

BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.

BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.

Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM.

Bosutinib (SKI-606) is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM, respectively.

Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.

Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.

CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM.

Deforolimus (Ridaforolimus, AP23573, MK-8669) is a selective mTOR inhibitor with IC50 of 0.2 nM.

Erlotinib HCl is an HER1/EGFR inhibitor with IC50 of 2 nM.

Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.

Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.

Nilotinib (AMN-107, Tasigna) is a Bcr-Abl inhibitor with IC50 less than 30 nM.

PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.

PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively.

Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM.

Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.

STF-62247 is selectively toxic and growth inhibitory to renal cells lacking VHL

Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Tandutinib (MLN518, CT53518) is an ATP-competitive and highly selective inhibitor of Flt3, PDGFRβ and c-Kit with IC50 of 0.22 μM, 0.20 μM and 0.17 μM, respectively.

Temsirolimus (CCI-779, Torisel) is a specific mTOR inhibitor with IC50 of 1.76 μM.

Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM.

Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM.

Vorinostat (suberoylanilide hydroxamic acid, SAHA, Zolinza) is an HDAC inhibitor with IC50 of ~10 nM.

VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with Kiapp of 0.6 nM, 18 nM and 4.6 nM, respectively.

Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM.

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells..

MS-275 is an HDAC inhibitor of HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively.

Enzastaurin (LY317615) is a potent PKC inhibitor for PKCβ, PKCα, PKCγ and PKCε with IC50 of 6 nM, 39 nM, 83 nM and 110 nM, respectively.

BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively.

Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1 and PARP2 with IC50 of 5 nM and 1 nM, respectively.

Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM.

Masitinib is a novel tyrosine kinases inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, resectively.

GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively.

SB 431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM.

Dasatinib (BMS-354825, Sprycel) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of ＜1 nM, 0.5 nM and 79 nM, respectively.

PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley.

NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor for HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively.

PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with IC50 of 9 nM.

ZSTK474 is a potent pan-class I PI3K inhibitor with IC50 of 37 nM.

SB 216763 is a potent and selective GSK-3α inhibitor with IC50 of 34.3 nM.

SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM.

MK-2206 2HCl is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC50 of 8 nM, 12 nM and 65 nM, respectively.

PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM, respectively.

SU11274 is a selective Met inhibitor with IC50 of 10 nM.

GDC-0449 (Vismodegib, HhAntag691) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.

Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively.

Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM in HeLa cell extracts.

BSI-201 (Iniparib, SAR240550) is a PARP1 inhibitor.

PCI-24781 (CRA-024781) is a novel broad spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively.

OSI-906 (Linsitinib) is a selective inhibitor of IGF-1R and IR with IC50 of 35 nM and 75 nM, respectively.

KU-55933 is a potent and specific ATM inhibitor with IC50 and Ki of 13 nM and 2.2 nM, respectively.

GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively.

PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM.

JNJ-26481585 (Quisinostat) is an HDAC inhibitor for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11 with IC50 of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM and 0.37 nM, respectively.

BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.

Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM.

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.

GDC-0879 is a novel potent, selective B-Raf inhibitor for B-RafV600E with IC50 of 0.13 nM.

LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, and also blocks autophagosome formation.

Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively.

TAE684 is a potent and selective ALK inhibitor with IC50 of 3 nM.

BI 2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM.

SGX-523 is a selective Met inhibitor with IC50 of 4 nM.

GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively.

JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM.

PD 0332991 is a highly selective inhibitor of CDK4/cyclin D1 and CDK6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively.

Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively.

XL147 (SAR245408) is a selective and reversible class I PI3K inhibitor for wild type and mutant p110α with IC50 of 40 nM and 40 nM, respectively.

Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.

TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.

MGCD0103 (Mocetinostat) is a potent HDAC inhibitor for HDAC1, HDAC2 and HDAC3 with IC50 of 0.15 μM, 0.29 μM and 1.66 μM, respectively.

Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM.

SRT1720 is a selective SIRT1 activator with EC1.5 of 0.16 μM.

YM155 is a potent IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) inhibitor for survivin with IC50 of 0.54 nM.

MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM.

AT9283 is a potent pan-Aurora inhibitor for Aurora A, Aurora B, JAK3, JAK2 and Abl with IC50 of 3 nM, 3 nM, 1.1 nM, 1.2 nM and 4 nM, respectively.

Pemetrexed disodium (Alimta) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

Andarine (GTX-007) is a selective nonsteroidal androgen receptor (AR) agonist with Ki of 4 nM.

17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM.

17-DMAG (Alvespimycin, KOS-1022, NSC 707545) is a potent HSP90 inhibitor with IC50 of 62 nM.

SNS-032 is a novel, potent and selective CDK inhibitor of CDK2, CDK7 and CDK9 with IC50 of 38 nM, 62 nM and 4 nM, respectively.

Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.

AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM.

Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.

Gemcitabine Hydrochloride (Gemzar) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

Paclitaxel (Taxol, Onxol, Nov-Onxol) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively.

SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3.4 nM, respectively.

Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.

Ganetespib is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells.

E7080 (Lenvatinib) is a multi-target inhibitor of VEGFR2 and VEGFR3 with IC50 of 4 nM and 5.2 nM, respectively.

ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules.

Cisplatin is an inorganic and water-soluble platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts.

CYC116 is a potent inhibitor of Aurora A/B and VEGFR with Ki of 8.0 nM/9.2 nM and 44 nM, respectively.

JNJ 26854165 (Serdemetan) is an orally bioavailable HDM2 (an E3 ligase) antagonist.

WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFRL858R and EGFRL858R/T790M with IC50 of 2 nM and 8 nM, respectively.

Ostarine (GTx-024, MK-2866, Enobosarm, S-22) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM.

BIIB021 is a novel inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectivley.

Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

XAV-939 is a selective Wnt β-catenin-mediated transcription inhibitor for TNKS1 and TNKS2 with IC50 of 11 nM and 4 nM, respectively.

ENMD-2076 is a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM/15.9 nM and 58.2 nM, respectively.

BIBR 1532 is a potent and selective telomerase inhibitor with IC50 of 100 nM.

PIK-90 is a potent and cell permeable inhibitor of p110α, p110β, p110γ and p110δ with IC50 of 11 nM, 350 nM, 18 nM and 58 nM, respectively.

Anastrozole inhibits the enzyme aromatase.

Substance P antagonists (SPA).

Bicalutamide (Casodex, Cosudex, Calutide, Kalumid) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM.

Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.094 nM.

Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.

CUDC-101 is a potent multi-target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, respectively.

Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.

Irinotecan (Camptosar, Campto, CPT-11) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

Cladribine (Leustatin, Litak, 2CDA) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.

Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively.

Dimesna is an uroprotective agent used to decrease urotoxicity.

PIK-75 is a selective and competitive inhibitor of p110α with IC50 of 5.8 nM and also potently inhibits DNA-PK with IC50 of 2 nM.

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.

Adrucil (Fluorouracil) is an DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS).

Abitrexate (Methotrexate) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.

Imiquimod(Aldara) is a novel synthetic agent with immune response modifying activity.

Bendamustine HCL (Ribomustin, Treanda, SDX-105) is a DNA-damaging agent with IC50 of 50 μM.

Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.

Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.

Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.

This agent inhibited cell proliferation of NCI-H727 with IC50 at 9.3 nM.

Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase

YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM.

OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.

Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers.

Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor with IC50 of 0.4 mM and also inhibits GABA-transaminase or succinicsemialdehyde dehydrogenase.

Thalidomide was introduced as a sedative drug,immunomodulatory agent and also is investigated for treating symptoms of many cancers.Thalidomide inhibits an E3 ubiquitin ligase， which is a CRBN-DDB1-Cul4A complex.

AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM and also inhibits PDGFR and c-Kit with IC50 of 1.72 nM and 1.63 nM, respectively.

Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.

Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

KU-0063794 is a potent and highly specific mTOR inhibitor for both mTORC1 and mTORC2 with IC50 ~10 nM.

Raloxifene is estrogen antagonists, inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.

Idarubicin HCl (Idamycin, Zavedos, 4-demethoxydaunorubicin) is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.

Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

Topotecan (Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.

2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.

Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM.

Leucovorin is a reduced folic acid.

Methazolastone (Temozolomide, Temodar, Temodal) is a DNA damage inducer.

Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM.

MP-470 (Amuvatinib) is a potent and multi-targeted inhibitor of c-KitD816H, PDGFαV561D and Flt3D835Y with IC50 of 10 nM, 40 nM and 81 nM, respectively.

Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM.

JNJ-7706621 is a potent and multi-target inhibitor for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, Aurora A and Aurora B with IC50 of 9 nM, 4 nM, 3 nM, 11 nM and 15 nM, respectively.

MDV3100 is an androgen-receptor (AR) antagonist with IC50 of 36 nM.

Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM.

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.

WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM.

PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.

IC-87114 is a selective inhibitor of PI3Kδ with IC50 of 0.5 μM.

BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively.

Altretamine(Hexalen) is an anti-neoplastic agent.

Carmofur (INN) is a pyrimidine analogue used as an antineoplastic agent.

Epothilone A is a Taxol-like microtubule-stabilizing agent with EC0.01 of 2 μM.

Floxuridine (Fludara) is a prodrugs of floxuridine and an oncology agent with an GI50 of 5.1 μM for the inhibition of MDCK/PEPT1.

Ftorafur is a substance being used in the treatment of some types of cancer.

Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.

Megestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HegG2.

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis.

Streptozotocin (Zanosar) is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

Dexamethasone is an anti-inflammatory and immunosuppressant.

Rigosertib (Estybon, Novonex, ON-01910) is a non-ATP-competitive inhibitor of PLK1 (Polo-like kinase 1) with IC50 of 9 nM.

Epothilone B is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM.

Dorzolamide HCl is a carbonic anhydrase inhibitor.

INCB018424 is a JAK family inhibitor for JAK1, JAK2 and JAK3 with IC50 of 2.7 nM, 4.5 nM and 322 nM, respectively.

It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

Pelitinib (EKB-569) is a potent EGFR inhibitor with IC50 of 38.5 nM.

Zileuton (ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.

Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM.

Tipifarnib (Zarnestra, R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM.

Zibotentan (ZD4054) is a specific Endothelin A (ETA) antagonist with IC50 of 21 nM.

Doxercalciferol (Hectorol) is a synthetic analog of vitamin D.

SB 525334 is a potent and selective inhibitor of TGF-β1 (ALK5) with IC50 of 14.3 nM.

AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM and also inhibits VEGFR2 and Flt with IC50 of 77 nM and 59 nM, respectively.

PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM, respectively.

PIK-93 is a novel and potent inhibitor of PI3Kγ and PI4KIIIβ with IC50 of 16 nM and 19 nM, respectively.

AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.

Fludarabine (Fludara, F-ara-A, NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor.

LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM.

Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.

SB939 is a potent HDAC inhibitor with IC50 of 40-140 nM.

CHR-2797 is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively.

XL765 is a dual inhibitor of mTOR/PI3k for mTOR, p110α, p110β, p110γ and p110δ with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM, respectively.

AT7519 is a novel multi-CDK inhibitor for CDK1/cyclin B, CDK2/Cyclin A, CDK3/Cyclin E, CDK4/Cyclin D1, CDK5/p35 and CDK6/Cyclin D3 with IC50 of 210 nM, 47 nM, 360 nM, 100 nM, 13 nM and 170 nM, respectively.

MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM.

AC220 (Quizartinib) is a potent and selective inhibitor of Flt3ITD and Fltwt with IC50 of 1.1 nM and 4.2 nM, respectively.

AZD7762 is a novel CHK1 and CHK2 inhibitor with IC50 of 5 nM and <10 nM, respectively.

R406 (free base) is a Syk inhibitor with IC50 of 41 nM.

DMXAA (ASA404) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively.

EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM.

Febuxostat (Uloric) is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM.

Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM.

AZD8055 is a novel ATP-competitive inhibitor of mTOR with IC50 of 0.8 nM.

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively.

Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM.

KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.

BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM.

Tie2 kinase inhibitor is a potent and selective Tie2 inhibitor with IC50 of 0.25 μM.

Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells.

Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

Triamcinolone Acetonide is a more potent type of triamcinolone, being about 8 times as effective as prednisone.

Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.

Tretinoin is an agent commonly used to treat acne vulgaris and keratosis pilaris.

Ezetimibe (Zetia) is a compound that lowers cholesterol.

Estrone is an estrogenic hormone.

Aminoglutethimide (AMG, Cytadren) is an aromatase inhibitor with IC50 of 10 μM.

Disulfiram is an agent used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.

Betapar(Meprednisone) is a glucocorticoid and a methylated derivative of prednisone.

Busulfan(Myleran, Busulfex) is a cell cycle non-specific alkylating antineoplastic agent.

Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.

Estradiol is the predominant sex hormone.

Gemcitabine(Gemzar) belongs to the group of medicines called antimetabolites.

Azathioprine(Azasan, Imuran) is a drug that suppresses the immune system and is used in organ transplantation and autoimmune disease.

Mesna(Uromitexan, Mesnex), a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents.

Toremifene Citrate(Fareston, Acapodene) is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.

Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.

Teniposide(Vumon)is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).

Simvastatin (Zocor) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM .

Ranolazine(Ranexa) is an antianginal medication.

Lomustine inhibits cancer cells by damaging the DNA and stops cells from dividing.

D-glutamine is a D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code.

Hydroxyurea (Cytodrox) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

Flutamide (Eulexin) is an oral nonsteroidal antiandrogen agent primarily used to treat prostate cancer.

Fluvastatin sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM.

Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding.

Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.

Sodium butyrate is a compound with formula Na(C3H7COO)

Maraviroc (Selzentry, UK-427857, Celsentri) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM, respectively.

PF 573228 is a inhibitor of FAK with IC50 of 4 nM.

Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM, respectively.

LDE225 (NVP-LDE225) is a smoothened antagonist with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.

AG14361 is a potent inhibitor of PARP1 with Ki of < 5 nM.

MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively.

MLN9708 is a selective inhibitor of chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM.

SB 743921 is a KSP inhibitor with IC50 of 0.2 nM, 0.07 nM, 1.7 nM, 0.06 nM and 14.4 nM in SKOV3, Colo205, MV522, MX1 and P388 cell lines, respectively.

GSK461364 inhibits purified Plk1 with Ki of 2 nM.

SGI-1776 is a novel ATP competitive inhibitor to Pim1, Pim2 and Pim3 with IC50 of 7 nM, 363 nM and 69 nM, respectively.

BMS794833 is a potent ATP competitive inhibitor of Met and VEGFR2 with IC50 of 1.7 nM and 15 nM, respectively.

OSI-420 is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for inhibition of human EGFR and EGFR autophosphorylation with IC50 of 2 nM and 20 nM, respectively.

R935788 (Fostamatinib disodium, R788) is a Syk inhibitor with IC50 of 41 nM.

Formestane(Lentaron(R)) is a second generation selective aromatase inhibitor with an IC50 of 80 nM.

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.

Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.

CYT387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC50 of 11 nM and 18 nM, respectively.

SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM.

Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor and also inhibits an E3 ubiquitin ligase called "anaphase-promoting complex/cyclosome (APC/C)".

CAL-101 is a selective PI3K class I inhibitor of p110δ with IC50 of 2.5 nM.

LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM.

Telatinib (BAY 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRβ with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively.

BI6727 (Volasertib) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM.

Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor for VEGF-A and bFGF with IC50 of 10 nM and 30 nM, respectively.

WP1130 (degrasyn) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also inhibits Bcr/Abl with IC50 of 1.8 μM.

AR-42 (HDAC-42, OSU-HDAC42) is a pan-HDAC inhibitor with IC50 30 nM.

CP-466722 is an potent and reversible ATM inhibitor.

BKM120 is a selective PI3K inhibitor of p110α, p110β, p110δ and p110γ with IC50 of 52-99 nM, 166 nM, 116 nM and 262 nM, respectively.

CX-4945 is a potent and selective inhibitor of CK2α and CK2α' with IC50 of 1 nM.

(-)-Epigallocatechin gallate is a potent anti-oxidant polyphenol flavonoid isolated from green tea.

Cyclosporin A (Cyclosporine A) is an immunosuppressant agent widely used in post-allogeneic organ transplant to reduce the activity of the immune system.

Gossypol is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.

Phloretin(Dihydronaringenin) is a dihydrochalcone, a type of polyphenol.

Aminoglutethimide (Cytadren) is an anti-steroid drug which inhibits aromatase.

Quercetin (Sophoretin) is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml.

Coenzyme Q10 (ubiquinone, ubidecarenone, coenzyme Q) is a component of the electron transport chain and participates in aerobic cellular respiration.

Chrysophanic acid (Chrysophanol) is a EGFR/mTOR pathway inhibitor.

Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

Itraconazole (Sporanox) is a triazole antifungal agent.

Mitoxantrone HCl is a classic folic acid antagonist.

Cyclophosphamide is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.

Vinpocetine is a selectively inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.

Mycophenolic acid (mycophenolate) is an immunosuppressant agent used to prevent rejection in organ transplantation.

Rosiglitazone (Avandia) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively.

Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

Pioglitazone (Actos) is a selective peroxisome proliferator-activated receptor gamma stimulator.

Mifepristone (Mifeprex, RU-486, RU-38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.

Lonidamine is an orally administered small molecule hexokinase inactivator with an IC50 of 0.85 mM.

TAK-733 is a potent, selective, non ATP-competitive MEK inhibitor with IC50 of 3.2 nM.

LDN193189 is a selective inhibitor of ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively.

LY2603618 (IC-83) is a selective Chk1 inhibitor with potential anti-tumor activity.

GW3965 is a potent, selective LXR agonist, which exhibits its potency in the LXRα/SRC1 LiSA and LXRα-GAL4 with EC50 of 125 nM and 190 nM, respectively.

DCC-2036 is a conformational control inhibitor of Abl1 and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, respectively.

NU7441 is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM.

GSK2126458 is a highly selective and potent inhibitor of p110α, p110β, p110γ, p110δ, mTORC1 and mTORC2 with Ki of 0.019 nM, 0.13 nM, 0.024 nM, 0.06 nM, 0.18 nM and 0.3 nM, respectively.

MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM in human SH-SY5Y cells.

PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM.

GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.

Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM.

PCI-32765 (Ibrutinib) is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM.

NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM.

WAY-362450 is a potent, selective FXR agonist with EC50 of 4 nM.

A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM and inhibits fatty acid synthesis with IC50 of 3.2 μM.

CH5132799 exhibits a strong inhibitory activity especially against PI3Kα with IC50 of 14 nM and also inhibits mTOR with IC50 of 1.6 µM.

KX2-391 (KX01) is a highly selective non ATP-competitive Src inhibitor with GI50 of 9-60 nM in cancer cell lines .

LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively.

YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch, respectively.

Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM.

AMG 900 is a potent and highly selective pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 5 nM, 4 nM and 1 nM, respectively.

PF-03814735 is a novel, potent and reversible inhibitor of both Aurora A and Aurora B with IC50 of 0.8 nM and 5 nM, respectively.

PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM.

PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively.

Crenolanib (CP-868596) is a potent and selective inihibitor of PDGFRα with IC50 of 10 nM in PDGFRα over-expressed CHO cells.

AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.

TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM.

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.

AZ628 is a potent inhibitor for wild-type CRAF and BRAFV600E with IC50 of 29 nM and 34 nM, respectively.

AT-406 is a potent IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) inhibitor of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.

Canagliflozin is a highly potent and selective SGLT2 inhibitor for CHO-hSGLT2, CHO-rSGLT2 and CHO-mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively.

3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM and also blocks autophagosome formation.

Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM.

Nocodazole inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively.

GW 4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM.

CP-690550 is a novel inhibitor of JAK3 with IC50 of 1 nM.

Sotrastaurin (AEB071) is a potent selective pan-PKC inhibitor and highly inhibits PKCθ with Ki of 0.22 nM.

APO866 effectively inhibits NAMPT with IC50 of 0.09 nM.

Sirtinol is a specific SIRT1 and SIRT2 inhibtor with IC50 of 131 μM and 38 μM, respectively.

CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM.

INK 128 is a potent and selective mTOR inhibitor with IC50 of 1 nM.

Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively.

RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM.

TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM.

Desmethyl Erlotinib (CP-473420) is a free base of OSI-420, which is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for human EGFR with IC50 of 2 nM.

Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

S-Ruxolitinib is a JAK family inhibitor for JAK1 and JAK2 with IC50 of 3.3 nM and 2.8 nM, respectively.

Bay 11-7082 inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM and inactivates the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13, UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively.

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit.

Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.

Anagrelide is a drug used for the treatment of essential thrombocytosis.

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.

FTY720 (Fingolimod, Gilenya) is a S1P antagonist with IC50 of 0.033 nM.

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs used as an anti-inflammatory and immunosuppressant.

ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively.

Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.

ABT-888 (Veliparib, NSC 737664) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.

Axitinib (AG-013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM, respectively.

BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.

BIBF1120 (Vargatef) is a potent inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.

Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.

Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.

Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.

Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

Lapatinib Ditosylate (GW572016, GW2016, Tykerb, Tyverb) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.

PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively.

Sorafenib Tosylate (Bay 43-9006, Nexavar) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.

Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Tandutinib (MLN518, CT53518) is an ATP-competitive and highly selective inhibitor of Flt3, PDGFRβ and c-Kit with IC50 of 0.22 μM, 0.20 μM and 0.17 μM, respectively.

VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with Kiapp of 0.6 nM, 18 nM and 4.6 nM, respectively.

Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells..

Enzastaurin (LY317615) is a potent PKC inhibitor for PKCβ, PKCα, PKCγ and PKCε with IC50 of 6 nM, 39 nM, 83 nM and 110 nM, respectively.

BMS-599626 (AC480) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, respectively.

Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1 and PARP2 with IC50 of 5 nM and 1 nM, respectively.

Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM.

Masitinib is a novel tyrosine kinases inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, resectively.

GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively.

Dasatinib (BMS-354825, Sprycel) is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of ＜1 nM, 0.5 nM and 79 nM, respectively.

NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor for HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively.

SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM.

MK-2206 2HCl is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC50 of 8 nM, 12 nM and 65 nM, respectively.

GDC-0449 (Vismodegib, HhAntag691) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.

Brivanib is an ATP-competitive inhibitor against human VEGFR2 and FGFR with IC50 of 25 nM and 148 nM, respectively.

PCI-24781 (CRA-024781) is a novel broad spectrum HDAC inhibitor targeting HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM, respectively.

JNJ-26481585 (Quisinostat) is an HDAC inhibitor for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11 with IC50 of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM and 0.37 nM, respectively.

BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.

LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, and also blocks autophagosome formation.

Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively.

GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively.

PD 0332991 is a highly selective inhibitor of CDK4/cyclin D1 and CDK6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively.

Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively.

XL147 (SAR245408) is a selective and reversible class I PI3K inhibitor for wild type and mutant p110α with IC50 of 40 nM and 40 nM, respectively.

TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.

MGCD0103 (Mocetinostat) is a potent HDAC inhibitor for HDAC1, HDAC2 and HDAC3 with IC50 of 0.15 μM, 0.29 μM and 1.66 μM, respectively.

YM155 is a potent IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) inhibitor for survivin with IC50 of 0.54 nM.

AT9283 is a potent pan-Aurora inhibitor for Aurora A, Aurora B, JAK3, JAK2 and Abl with IC50 of 3 nM, 3 nM, 1.1 nM, 1.2 nM and 4 nM, respectively.

Pemetrexed disodium (Alimta) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

SNS-032 is a novel, potent and selective CDK inhibitor of CDK2, CDK7 and CDK9 with IC50 of 38 nM, 62 nM and 4 nM, respectively.

Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.

Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.

Gemcitabine Hydrochloride (Gemzar) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

Paclitaxel (Taxol, Onxol, Nov-Onxol) is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively.

SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3.4 nM, respectively.

Capecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.

E7080 (Lenvatinib) is a multi-target inhibitor of VEGFR2 and VEGFR3 with IC50 of 4 nM and 5.2 nM, respectively.

Cisplatin is an inorganic and water-soluble platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts.

WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFRL858R and EGFRL858R/T790M with IC50 of 2 nM and 8 nM, respectively.

Ostarine (GTx-024, MK-2866, Enobosarm, S-22) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM.

Regorafenib (BAY 73-4506, Fluoro-Sorafenib) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

XAV-939 is a selective Wnt β-catenin-mediated transcription inhibitor for TNKS1 and TNKS2 with IC50 of 11 nM and 4 nM, respectively.

ENMD-2076 is a selective inhibitor of Aurora A and Aurora B with IC50 of 14 nM and 350 nM and also inhibits Flt3, Flt4 and VEGFR2 with IC50 of 1.86 nM/15.9 nM and 58.2 nM, respectively.

PIK-90 is a potent and cell permeable inhibitor of p110α, p110β, p110γ and p110δ with IC50 of 11 nM, 350 nM, 18 nM and 58 nM, respectively.

Bicalutamide (Casodex, Cosudex, Calutide, Kalumid) is an androgen receptor (AR) antagonist with IC50 of 0.16 μM.

Raltitrexed (Tomudex) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.

CUDC-101 is a potent multi-target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, respectively.

Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.

Irinotecan (Camptosar, Campto, CPT-11) is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.

Cladribine (Leustatin, Litak, 2CDA) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.

Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively.

PIK-75 is a selective and competitive inhibitor of p110α with IC50 of 5.8 nM and also potently inhibits DNA-PK with IC50 of 2 nM.

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.

Adrucil (Fluorouracil) is an DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS).

Abitrexate (Methotrexate) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.

Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.

Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells.

OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.

Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor with IC50 of 0.4 mM and also inhibits GABA-transaminase or succinic

Thalidomide was introduced as a sedative drug,immunomodulatory agent and also is investigated for treating symptoms of many cancers.Thalidomide inhibits an E3 ubiquitin ligase， which is a CRBN-DDB1-Cul4A complex.

AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 0.21 nM/0.16 nM/0.24 nM and also inhibits PDGFR and c-Kit with IC50 of 1.72 nM and 1.63 nM, respectively.

Epirubicin HCl, a semisynthetic L-arabino derivative of doxorubicin, is an antineoplastic agent by inhibiting Topoisomerase.

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.

Raloxifene is estrogen antagonists, inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.


Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.

Topotecan (Hycamtin, NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.

MP-470 (Amuvatinib) is a potent and multi-targeted inhibitor of c-KitD816H, PDGFαV561D and Flt3D835Y with IC50 of 10 nM, 40 nM and 81 nM, respectively.

JNJ-7706621 is a potent and multi-target inhibitor for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, Aurora A and Aurora B with IC50 of 9 nM, 4 nM, 3 nM, 11 nM and 15 nM, respectively.

PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.

BX795 is a potent and specific TBK1, IKKε and PDK-1 inhibitor with IC50 of 6 nM, 41 nM and 111 nM, respectively.

Floxuridine (Fludara) is a prodrugs of floxuridine and an oncology agent with an GI50 of 5.1 μM for the inhibition of MDCK/PEPT1.

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

Streptozotocin (Zanosar) is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

Rigosertib (Estybon, Novonex, ON-01910) is a non-ATP-competitive inhibitor of PLK1 (Polo-like kinase 1) with IC50 of 9 nM.

INCB018424 is a JAK family inhibitor for JAK1, JAK2 and JAK3 with IC50 of 2.7 nM, 4.5 nM and 322 nM, respectively.

It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

Zileuton (ZYFLO) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.

Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM.

AEE788 is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM and also inhibits VEGFR2 and Flt with IC50 of 77 nM and 59 nM, respectively.

PHA-793887 is a novel and potent inhibitor of CDK2, CDK5 and CDK7 with IC50 of 8 nM, 5 nM and 10 nM, respectively.

AP24534 is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively.

Mycophenolate mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively.

CHR-2797 is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively.

XL765 is a dual inhibitor of mTOR/PI3k for mTOR, p110α, p110β, p110γ and p110δ with IC50 of 157 nM, 39 nM, 113 nM, 9 nM and 43 nM, respectively.

AT7519 is a novel multi-CDK inhibitor for CDK1/cyclin B, CDK2/Cyclin A, CDK3/Cyclin E, CDK4/Cyclin D1, CDK5/p35 and CDK6/Cyclin D3 with IC50 of 210 nM, 47 nM, 360 nM, 100 nM, 13 nM and 170 nM, respectively.

AC220 (Quizartinib) is a potent and selective inhibitor of Flt3ITD and Fltwt with IC50 of 1.1 nM and 4.2 nM, respectively.

DMXAA (ASA404) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively.

BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively.

Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.

Disulfiram is an agent used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.

Azathioprine(Azasan, Imuran) is a drug that suppresses the immune system and is used in organ transplantation and autoimmune disease.

Mesna(Uromitexan, Mesnex), a sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents.

Toremifene Citrate(Fareston, Acapodene) is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.

Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.

Teniposide(Vumon)is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL).

D-glutamine is a D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code.

Hydroxyurea (Cytodrox) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.

Maraviroc (Selzentry, UK-427857, Celsentri) is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM, respectively.

Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.

LDE225 (NVP-LDE225) is a smoothened antagonist with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.

MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively.

MLN9708 is a selective inhibitor of chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM.

SB 743921 is a KSP inhibitor with IC50 of 0.2 nM, 0.07 nM, 1.7 nM, 0.06 nM and 14.4 nM in SKOV3, Colo205, MV522, MX1 and P388 cell lines, respectively.

SGI-1776 is a novel ATP competitive inhibitor to Pim1, Pim2 and Pim3 with IC50 of 7 nM, 363 nM and 69 nM, respectively.

BMS794833 is a potent ATP competitive inhibitor of Met and VEGFR2 with IC50 of 1.7 nM and 15 nM, respectively.

OSI-420 is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for inhibition of human EGFR and EGFR autophosphorylation with IC50 of 2 nM and 20 nM, respectively.

Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor and also inhibits an E3 ubiquitin ligase called "anaphase-promoting complex/cyclosome (APC/C)".

Telatinib (BAY 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRβ with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively.

Palomid 529 (P529) is a PI3K/Akt/mTOR inhibitor for VEGF-A and bFGF with IC50 of 10 nM and 30 nM, respectively.

WP1130 (degrasyn) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also inhibits Bcr/Abl with IC50 of 1.8 μM.

BKM120 is a selective PI3K inhibitor of p110α, p110β, p110δ and p110γ with IC50 of 52-99 nM, 166 nM, 116 nM and 262 nM, respectively.

Cyclosporin A (Cyclosporine A) is an immunosuppressant agent widely used in post-allogeneic organ transplant to reduce the activity of the immune system.

Gossypol is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.

Coenzyme Q10 (ubiquinone, ubidecarenone, coenzyme Q) is a component of the electron transport chain and participates in aerobic cellular respiration.

Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

Cyclophosphamide is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.

Vinpocetine is a selectively inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease.

Mycophenolic acid (mycophenolate) is an immunosuppressant agent used to prevent rejection in organ transplantation.

Rosiglitazone (Avandia) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively.

Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.

Mifepristone (Mifeprex, RU-486, RU-38486, Mifegyne) is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.

GW3965 is a potent, selective LXR agonist, which exhibits its potency in the LXRα/SRC1 LiSA and LXRα-GAL4 with EC50 of 125 nM and 190 nM, respectively.

DCC-2036 is a conformational control inhibitor of Abl1 and Abl1(T315I) with IC50 of 0.8 nM and 4 nM, respectively.

NU7441 is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM.

GSK2126458 is a highly selective and potent inhibitor of p110α, p110β, p110γ, p110δ, mTORC1 and mTORC2 with Ki of 0.019 nM, 0.13 nM, 0.024 nM, 0.06 nM, 0.18 nM and 0.3 nM, respectively.

MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM in human SH-SY5Y cells.

GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC50 of 0.92 nM and 1.8 nM, respectively.

Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM.

A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM and inhibits fatty acid synthesis with IC50 of 3.2 μM.

CH5132799 exhibits a strong inhibitory activity especially against PI3Kα with IC50 of 14 nM and also inhibits mTOR with IC50 of 1.6 µM.

LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively.

YO-01027 (Dibenzazepine, DBZ) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch, respectively.

AMG 900 is a potent and highly selective pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 5 nM, 4 nM and 1 nM, respectively.

PF-03814735 is a novel, potent and reversible inhibitor of both Aurora A and Aurora B with IC50 of 0.8 nM and 5 nM, respectively.

PF299804 is a potent, irreversible pan-ErbB inhibitor against ErbB1, ErbB2 and ErbB4 with IC50 of 6 nM, 45.7 nM and 73.7 nM, respectively.

Crenolanib (CP-868596) is a potent and selective inihibitor of PDGFRα with IC50 of 10 nM in PDGFRα over-expressed CHO cells.

AT-406 is a potent IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) inhibitor of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.

Canagliflozin is a highly potent and selective SGLT2 inhibitor for CHO-hSGLT2, CHO-rSGLT2 and CHO-mSGLT2 with IC50 of 4.4 nM, 3.7 nM and 2 nM, respectively.

3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM and also blocks autophagosome formation.

Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively.

Desmethyl Erlotinib (CP-473420) is a free base of OSI-420, which is an active metabolite of Erlotinib which is an orally active EGFR inhibitor for human EGFR with IC50 of 2 nM.

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.

Bay 11-7082 inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM and inactivates the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13, UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively.

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit.

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs used as an anti-inflammatory and immunosuppressant.

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