feeding the critically ill infant and child
DESCRIPTION
Feeding the critically ill infant and child. By : Shihaam Cader Principal Dietitian [HOD] Red Cross Children's Hospital. By : Prof A Argent Head PICU Red Cross Children's Hospital. By : Dr L Goddard GIT Consultant Red Cross Children's Hospital. Introduction. - PowerPoint PPT PresentationTRANSCRIPT
Red Cross Childrens Hospital : Refresher Course Feb 2010
Feeding the critically ill infant and child
By : Shihaam CaderPrincipal Dietitian [HOD]Red Cross Children's Hospital
By : Prof A Argent Head PICURed Cross Children's Hospital
By : Dr L GoddardGIT ConsultantRed Cross Children's Hospital
Red Cross Childrens Hospital : Refresher Course Feb 2010
Introduction
• Nutrition is an essential part of the treatment and management of critically ill infants and children
• Its benefits include maintaining vital body
functions, reducing the effects of catabolism
• And reducing morbidity, mortality and length of hospital stay
Red Cross Childrens Hospital : Refresher Course Feb 2010
Introduction
•Optimal nutrition is challenging task since, age, type of diagnosis, injury & individual metabolic response may vary between patients
•Basic concepts of managing these patients needs to be highlighted for optimal nutrition therapy
• Main areas are:
•Early enteral feeding
• Calories needed for critically ill
• Ways to overcome barriers related to nutrition therapy
Red Cross Childrens Hospital : Refresher Course Feb 2010
An approach to feeding the
critically ill infant & child
Red Cross Childrens Hospital : Refresher Course Feb 2010
Feed protocol
• Studies have shown that feeding protocols may assist in achieving optimal nutritional care
• Using standardized feeding protocol, will alleviate some of the barriers
• Feeding protocol development should be multi-disciplinary including dietitians, nursing, medical team
Red Cross Childrens Hospital : Refresher Course Feb 2010
Enteral Feeding protocolSTEP 1
Nutritional assessment
ABCD approach
STEP 5
Monitoring tolerance of feeding•Input
•Output: vomiting, stools, NGA
•Other: abdominal distention
STEP 2
Early Enteral Nutrition
Initiate within 24 hoursSTEP 4
Route of feeding•Naso/oro-gastric feeding•Nasojejenal feeding
STEP 3
Type & rate of feeding•Depends on age, nutritional needs, fluid restrictions, disease condition
Total Parenteral Nutrition
Only considered if all the above steps have failed and not able to achieve enteral nutrition by day 3-5 of NPM
STEP 6
Managing the barriers to feeding•Interruptions to feeding & calorie deficits
•GI disturbances: vomiting, stools, NGA
•Fluid restrictions
Red Cross Childrens Hospital : Refresher Course Feb 2010
Enteral Feeding protocol
STEP 1
Nutritional assessment
ABCD approach
Red Cross Childrens Hospital : Refresher Course Feb 2010
Nutrition Assessment
ABCD approach
Anthropometry•Weight, length, classifications, growth charts, NRS
Biochemistry/Special Investigations•Electrolytes, CMP, hemoglobin, etc•FOG,Fecal elastase, alpha1 antitrypsin, etc
Clinical Considerations•Disease specific nutritional management
Dietary Assessment • Diet history•Energy and protein requirements•Choosing appropriate feeds•Determining the route of feeding
Red Cross Childrens Hospital : Refresher Course Feb 2010
Anthropometry
• Difficult to assess accurate growth parameters or trends in ICU setting
• However basics still needs to be evaluated:
• Weight
•Height or length
• Growth charts
•Other measurements done when weight is not a true reflection eg. MUAC -not affected by edema
Red Cross Childrens Hospital : Refresher Course Feb 2010
Growth trends
Growth charts used to classify patients, eg, wasting and stunting, acute or chronic malnutrition
Red Cross Childrens Hospital : Refresher Course Feb 2010
• Abnormal growth factors needs monitoring and restored
• If they are abnormal, growth and development is not possible no matter how much calories are provided
• Growth factors are:
SODIUM
MAGNESIUMPOTASSIUM
PHOSPHATE
CALCIUM
HEMOGLOBIN
Biochemistry
Red Cross Childrens Hospital : Refresher Course Feb 2010
•Albumin: Poor marker of nutrition & rather prognostic indicator
• Most abundant plasma protein with MW of 65 kDa, synthesized by liver•Half - life of 20 days• Many other causes for hypoalbuminemia:
• Decreased synthesis or increase losses• Dilutional - fluid retention, edema• Increased catabolism of albumin - sepsis, acute phase response
•Lactate: indicator of tissue perfusion
•Prealbumin and CRP:
•Prealbumin has a half-life of 24-48 hours• Prealbumin + CRP are inversely related
• Increase CRP + decrease Prealbumin = acute phase
Biochemistry
Nutrition 2009 (25)1004-1005
[ASPEN 2009]
Red Cross Childrens Hospital : Refresher Course Feb 2010
• Assessing the patients body for any signs of nutritional deficiencies, such as sparse hair, wasting, etc
•Diagnosis plays a large part on the type of nutritional regime required, such as :
Liver disease Renal disease
Cardiac diseaseChronic lung disease
Critically ill Burns
Severe malnutritionMetabolic disorders
Clinical assessment/diagnosis
Red Cross Childrens Hospital : Refresher Course Feb 2010
•Once the nutritional status and clinical diagnosis is determined, a dietary plan is prescribed for the medical team
•Dietary plan includes:
•Calories and protein required
•Type of feed
•Rate / volume of feed
• Route of feedEnterally OR Parenterally
Orally OR Nasogastric OR Nasojejenally OR Gastrostomy
Dietary assessment and management
Red Cross Childrens Hospital : Refresher Course Feb 2010
Energy
• Gold standard of determining energy expenditure is with the use of indirect calorimeter
• Predictive equations are used for practical reasons – but needs to be noted to either under or over estimate
• Energy needs are lower during acute phase and increases when in the recovery phase
• Overfeeding is found to be as detrimental as underfeeding
•Excess CHO – lipogenesis, hyperglycemia, prolongs duration of mechanical ventilation & hospital stay
Red Cross Childrens Hospital : Refresher Course Feb 2010
Protein
• Adequate protein needed for lean body mass, wound healing
• Those fed high protein [~2,8g/kg] had positive protein balance and lower protein oxidation compared to those fed 1.7g/kg
• Infants need:
•7.5 -12% of energy for protein
• Childrens need:
• 5 – 15% energy for protein
Catch – up growth
• 9% protein and adequate micronutrients requiredJ Hum Nutr Diet 2007;20:329
Red Cross Childrens Hospital : Refresher Course Feb 2010
Additional nutrients...
• Thamine – deficient in malnourished patient
• Folate – anemia and antioxidant properties
•Zinc
• required for protein metabolism, wound healing, immune function, antioxidant properties
• involved in many enzyme functions
•Particularly given to malnourished patients, burns, diarrhea
Red Cross Childrens Hospital : Refresher Course Feb 2010
Enteral Feeding protocol
STEP 1
Nutritional assessment
ABCD approach
STEP 2
Early Enteral Nutrition
Initiate within 24 hours
Red Cross Childrens Hospital : Refresher Course Feb 2010
Early enteral nutrition
• Initiate enteral nutrition within 24 hours once hemodynamically
stable
• Feeding started after 72 hours has shown increase risk of gut
permeability, bacterial translocation and increased inflammatory
response
• The initiation of Early enteral nutrition- unless:• Patient is unstable requiring frequent resusc. or
vasopressor manipulation• Patient will be orally fed within next 24 hours• Anticipated extubation or intubation in next 6 hours• Patient is NPO for a procedure• There is a contra indication for feeds
Red Cross Childrens Hospital : Refresher Course Feb 2010
Enteral Feeding protocol
STEP 1
Nutritional assessment
ABCD approach
STEP 2
Early Enteral Nutrition
Initiate within 24 hoursSTEP 3
Type & rate of feeding
•Depends on age, nutritional needs, fluid restrictions, disease condition
Red Cross Childrens Hospital : Refresher Course Feb 2010
Types and rate of feeding
Rate of feeding
• Enteral feeding is recommended to maintain gut integrity
•Depending on age/size of infant and child, initiate starting rate
• 50 -60% of maintenance volume for age
• Goal of feeding to be achieved within 2-3 days
If the gut is working enteral feeding rate need NOT be cautiously introduced UNLESS there has been a surgical procedure or the patient is shocked
Red Cross Childrens Hospital : Refresher Course Feb 2010
Breastfeeding
• Complete with all the nutrients needed to ensure good growth.
• Has growth factors suitable for bowel adaptation
• Easily digested.
• Protective factors against common infections.
• Improves cognitive development
• Safe and clean
• and FREE.
• Bonding
Types of feeds: Infants
Red Cross Childrens Hospital : Refresher Course Feb 2010
Expressed breastmilk
• Should be included in the protocol
• Moms should shown how to express and provided with cups or bottles needed to express into
• Encouragement is needed and reassured that frequent times of expressing will increase their supply
• Small amounts of EBM to placed into mouth for comfort
Types of feeds: Infants
Red Cross Childrens Hospital : Refresher Course Feb 2010
Alternative to breastfeeding
Types of enteral nutrition [infants & children]:
1. Standard infant formula
2. Energy dense formula,
3. Soya based formula,
4. Hydrolysed formula [peptide based]
5. Amino acid based
6. Specialized products, eg, for management of chylothorax
All these products needs to administered in safest way due to the risk of bacterial contamination...
Red Cross Childrens Hospital : Refresher Course Feb 2010
Closed enteral feeding system
• Recommended for institutions with patients
who are critically ill , immuno-compromised
• Increased risk of bacterial contamination of
powdered milk products if not prepared and
handled correctly
• Benefits other than safety include:
• Quality of product
• No labour required – ready available
Red Cross Childrens Hospital : Refresher Course Feb 2010
Types of enteral nutrition available
1. Standard infant formula
• complete polymeric
•67kcal/ml and 1.5g protein/100ml
2. Energy dense formula,
• complete feed
•1.0kcal/ml and 2.6g protein / 100ml
3. Soya based formula,
• complete lactose free, 67kcal/ml and 1.6g protein / 100ml
4. Hydrolysed formula [peptide based + LCT + MCT]
5. Amino acid based [+LCT]
6. Specialized products, eg, for management of chylothorax
Infant products [0-1 year]
Red Cross Childrens Hospital : Refresher Course Feb 2010
Types of enteral nutrition available
1. Standard infant formula
• complete polymeric, usually with soluble fibre
•1.0kcal/ml and 2.8 - 3g protein/100ml
2. Energy dense formula,
• complete feed
•1.5kcal/ml and 3.8g protein / 100ml
3. Hydrolysed formula [peptide based + LCT + MCT]
5. Amino acid based [+LCT]
6. Specialized products, eg, for management of chylothorax
Pediatric products [1-10 year]
Note: ALL pediatric products are lactose free
Red Cross Childrens Hospital : Refresher Course Feb 2010
Concentration of feeds...1. Feed Supplementation can be requested when the calories cannot be achieved because of fluid restrictions
• However maximum concentrations should not be exceeded, i.e:
• Carbohydrate concentrations [g/100ml]
• < 6 mths: 10 -12%
• 6-12 mths: 12- 15%
• 1-2 yrs: 15 – 20%
• children: 20 – 30%
•Fat concentrations [g/100ml]
• Infants: 5 – 6 %
• Children: 7%Note: No supplementation is recommended if there is diarrhea or any malabsorption
Red Cross Childrens Hospital : Refresher Course Feb 2010
Concentration of feeds...
Type of feed supplementation
• CHO
•glucose polymer – lesser osmotic effect than mono – or disaccharides
•Added in increments of 1%
• Fat
• LCT – lower osmotic effect and source of EFAs
• MCT – only for fat malabsorption
• higher osmotic effect and can cause abdominal cramps
Red Cross Childrens Hospital : Refresher Course Feb 2010
Enteral Feeding protocolSTEP 1
Nutritional assessment
ABCD approach
STEP 2
Early Enteral Nutrition
Initiate within 24 hoursSTEP 4
Route of feeding•Naso/oro-gastric feeding•Nasojejenal feeding
STEP 3
Type & rate of feeding
•Depends on age, nutritional needs, fluid restrictions, disease condition
Red Cross Childrens Hospital : Refresher Course Feb 2010
Route of feeding
Recommendations are to initiate gastric feeding first with transition to jejenal feeding if the gastric route is not tolerated
Gastric feeding
• More physiological - Well tolerated , safe and easily placed
• However, due to GIT complications, small bowel feeding can be considered
Small bowel feeding [jejenum]
• Tolerated in most patients in the ICU
•But not easy to site & requires AXR to ensure accurate placement
• Also likely to be dislodged and blocked
• However, maintains adequate feeds by allowing less NPM periods prior to any procedure, such as, surgery or extubation
Red Cross Childrens Hospital : Refresher Course Feb 2010
Remember when using nasojejenal feeding:
• CAUTION: Use in preterms/neonates
• And cyanotic heart disease patients should not
be given NJT feeds due to risk of NEC [JPGN 2007]
• No bolus feeding can be administered
• No water solutions is advised via NJT [JPEN 2004;28;27]
Nutrition; 2007:23;16-22
Route of feeding
Red Cross Childrens Hospital : Refresher Course Feb 2010
Pro’s & Cons to both– Often remains
preference of unit
Bolus– More physiological– However, ICU is not a
normal environment!– Difficulties with
monitoring tolerance– Requires additional
nursing time
Continuous– Less time consuming– Easier to monitor– May delay gastric
emptying [adult ICU]– May reduce gall bladder
contraction
Absence of consensus
– Adequate delivery of nutrients should be main goal
– This should not be hampered by route
Shaw & Lawson 2007 3rd Ed
Route of feeding
Red Cross Childrens Hospital : Refresher Course Feb 2010
Enteral Feeding protocolSTEP 1
Nutritional assessment
ABCD approach
STEP 5
Monitoring tolerance of feeding•Input
•Output: vomiting, stools, NGA
•Other: abdominal distention
STEP 2
Early Enteral Nutrition
Initiate within 24 hoursSTEP 4
Route of feeding•Naso/oro-gastric feeding•Nasojejenal feeding
STEP 3
Type & rate of feeding
•Depends on age, nutritional needs, fluid restrictions, disease condition
Red Cross Childrens Hospital : Refresher Course Feb 2010
Monitoring the tolerance of feeding
Common complications are:
1. Vomiting• Prokinetic – erythromycin low dose 2 – 10mg/kg 6 hourly• NJT • Reflux - consider omeprazole
2. High gastric aspirates• No actual reference values – except for any amount of greater than
50% of volume administered in the previous 4 hours [Curr Opin Clin Nutr Met ab Care 2009]
3. Diarrhea
• Sepsis – related, antibiotic use• If persists – investigate stool MC+S, reducing sub, Fecal
omolar gap
4. Constipation
5. Refeeding syndrome
Red Cross Childrens Hospital : Refresher Course Feb 2010
Enteral Feeding protocolSTEP 1
Nutritional assessment
ABCD approach
STEP 5
Monitoring tolerance of feeding•Input
•Output: vomiting, stools, NGA
•Other: abdominal distention
STEP 2
Early Enteral Nutrition
Initiate within 24 hoursSTEP 4
Route of feeding•Naso/oro-gastric feeding•Nasojejenal feeding
STEP 3
Type & rate of feeding
•Depends on age, nutritional needs, fluid restrictions, disease condition
STEP 6
Managing the barriers to feeding•Interruptions to feeding & calorie deficits
•GI disturbances: vomiting, stools, NGA
•Fluid restrictions
Red Cross Childrens Hospital : Refresher Course Feb 2010
Managing the barriers to feedingMain barriers to optimum feeding:
1.Fluid restrictions• Common for infants/ children restricted to 40 –
60ml/kg/day• Most common in cardiac infant and those with
severe pneumonia• Prioritizing the use of fluid for nutrition • Using energy dense formula
2.Feed interruptions• Interruption of feeds – procedures/ trial extubation
• Feeds - often re-started at a graded rate – takes days to get back to full volume
• Using NJT feeds may assist in reducing time periods of NPM if patient is expected to have many procedures done in ICU, eg burns
Red Cross Childrens Hospital : Refresher Course Feb 2010
• Assessment of nutrition needs– Daily assessment of actual nutrition intake vs.
required– Calculation of cumulative energy deficit
• Enteral formula with high energy density– < 1 yr 1kcal/ml– > 1 yr 1.5kcal/ml– Bolus flushes with MCT/LCT & CHO powder– Do not exceed recommendations and
concentration of feeds• Note: not to exceed protein levels i.e
– Infants 4g/kg– Children 3g/kg
Curr Op Clin Nutr Met Care. 2006; 9: 297-303
Optimise calories and reduce calorie deficits
Red Cross Childrens Hospital : Refresher Course Feb 2010
Adult studies:• Glutamine
– fuel for enterocytes• Arginine
– cautioned in use of septic-critically ill• Omega-3s
– anti-inflammatory / antioxidant properties– Acute respiratory distress syndrome [ARDS]
Pediatrics:• Limited evidence does NOT support the use of these
products in PICU yet• May have detrimental effects
ASPEN 2009Nutrition 2005; 21: 799 - 807
Immunonutrition
Red Cross Childrens Hospital : Refresher Course Feb 2010
When enteral nutrition fails…
Total parenteral is only considered for the following reasons:
1. Unable to feed enterally due to abdominal surgery and/or loss of gut function
2. If enteral nutrition is not tolerated, i.e.
• Ongoing losses through, NGAs, chylothorax, malabsorption
• Not able to meet all calorie needs orally or NPM for 3 days
TPN needs close monitoring for all complications, namely: sepsis, liver dysfunction
Red Cross Childrens Hospital : Refresher Course Feb 2010
Conclusion
• Nutrition is integral part of management
• Early enteral nutrition needs to be initiated 24hrs
• Energy needs are reduced in acute phase & then increases in the recovery phase
• Enteral nutrition is well tolerated and choice of types and routes of delivery can improve the tolerance of feeding
• Main barriers of feeding are challenging
•But with the help of standardized feeding protocol and a multidisciplinary team, these challenges can be effectively managed
Red Cross Childrens Hospital : Refresher Course Feb 2010
Thank you!
Acknowledgements:
L Marino [certain slides]
Prof Argent and Dr Goddard
Red Cross Childrens Hospital : Refresher Course Feb 2010
References
1. Nutrition support to pediatrics within the pediatric intensive setting. Pediatr Anesthesia 2009; 19:300-312
2. Strategies to manage GI symptoms: Complications of EN JPEN 2009;33:21
3. ASPEN Clinical guidelines: Nutrition support of critically ill child.JPEN 2009;33:260
4. The impact of enteral feeding protocols on nutritional support in critically ill children. JHum NutrDiet 2009;22:428-436
5. Nutrition therapy in critically ill infants and children.JPEN 2008;32:52
6. GI compliations in critically ill: whar differs between adults and children. Curr OpinClin Nutr Metab Care.2009;12:180-185
7. Critically ill infants benefit from early administration of and energy-enriched formula. Clinical Nutrition 2009;28:249-255