hosm@uc.edu

tracie@pinkribbongirls.org

Breast cancer: Windows of Susceptibility. NIH grant 1U01ES019480

PINK RIBBON GIRLS

Vitamin D..........................................1Apples and nutrition......................2

Early development.........................3Butternut Squash soup..................4

Coffee Talks..................................6

Crossword puzzles........................7Nutrient dense food.....................9Wordsearch................................10Yoga Pose......................................12Pink ribbon gift tags.....................13

TO PREVENT the occurrence of BCa through RESEARCH and EDUCATION

TO ENCOURAGE and SUPPORT BCa survivors, friends and families.

Contacts

askdrmeiho@gmail.com

December 2013 Issue 37Breast Cancer

MYTHs,FACTs,CHOICEsand

COMMUNITY PARTNERS

INDEXRESEARCH PARTNERS

1

Vitamin D

Krishnan AV, Trump DL, Johnson CS, Feldman D.The role of vitamin D in cancer prevention and treatment.

Anticancer Res. 2012 Jan;32(1):211-21.Vitamin D: potential in the prevention and treatment of lung cancer. Norton R, O'Connell MA

Endocrinol Metab Clin North Am. 2010 Jun;39(2):401-18, table of contents. doi: 10.1016/j.ecl.2010.02.011.

Calcitriol, also called1,25-dihydroxyvitamin D , is the active form of vitamin D. It is involved 3in cell proliferation and differentiation and can affect some types of malignant cells. It appears to retard cell proliferation in tumors in animal models, and as such is being evaluated for anticancer potency in several human cancers. Calcitriol also stimulates a form of cell death called apoptosis. It suppresses inflammation and slows angiogenesis, which is the production of new blood vessels in tumor areas, and decreases risk of metastasis. Clinical trials for the use of vitamin D3 and other similar compounds are in progress.

Vitamin D has been recognized for some time for its role in bone development and most people are nominally familiar with the diseases of resulting from its deficiency like rickets and osteomalacia. Vitamin D is crucial for calcium absorption from the intestine, and assists in the regulation of calcium and phosphorous balance. Food sources of vitamin D are limited (some fish, egg yolks, fortified cereals are a good sources) and the body can synthesize vitamin D in the skin from sunlight. Taking too much vitamin D as extra supplements (the body knows when to stop making vitamin D) may cause kidney damage.

The effects of vitamin D on other tissues include anti-tumorigenic and immuno-modulatory effects. Evidence from observational studies, animal models and in vitro cell culture suggest that vitamin D may play a beneficial role in pulmonary inflammation and prevention of lung cancer.

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calcitriolwhich now has three oxygen molecules, as 1,25-

dihydroxyvitamin D(3) circulates as the active hormone that helps absorption of calcium from the intestines. helps regulat the balance of calcium and phosphate in the blood, is important in remodeling of bone, and also has a role in a healthy immune

system and optimal neuro-muscular function

cholecalciferolis converted to calcidiol in the liver (see TWO red oxygen molecules) get added

along with a few other changes

calcidiolis then converted to calcitriol in the kidneys and also by some of the white cells of the

blood (monocytes)

cholecalciferol is produced photochemically in the basal layers of the

epidermis of the skin from 7-dehydrocholesterol interacting with UV-B rays from the sun (those rays which are found between 10 - 2 pm mostly and very

little during the winter)

JUST FOR FUNMOLECULARSTRUCTURES

2

RESEARCH PARTNERS

QUESTION: Why are girls hitting puberty before 9?

ANSWER:

3

SOLUTION:

Here is a report on an BECRP program studying breast cancer, see the link to the picture for the original article in MSN healthy living, which is related toresearch conducted by some of our colleagues in the BCERP program.

They suggest that girls begin developing breasts around the age of 9 and those who were of more than median weight began sooner. Overall weight of young girls is greater than it was in the 1990s and according to Dr. Frank Biro, at Cincinnati Children's Hospital, this is another testiment to the fact that America has a high body-mass index. Their study was published in the journal Pediatrics in November 2013. Though body weight increase over the last two decades is important in determining when puberty will begin, there is some indication that this is not the only issue, and this led them to think of environmental factors, besides their daily intake of food, including encounters with chemicals in the environment. The link between early puberty and breast cancer is more or less indirect in its effect as an earlier onset of hormonal influences can be tied to long term health risks which not only include breast cancer but increased risk of high blood pressure, heart disease and diabetes in adulthood.

The solution might include 1) finding ways to improve our children's diet, (not necessarily meaning "more"of "less" but rather "different" foods, e.g. maybe eliminating cola altogehter, not switching to diet cola but or eliminating chips, not just reducing quantity or switching to chips with lower fat, transfats and salt, but chips altogether for . This benefit is doubled 1) it reduces the risk of disease and it increases health and lowers breast cancer risk. How many times can we be lucky enough to make a choice that not only mitigates weight problems, but benefits in amazing other ways? 2) it also brings economic pressures to bear on the companies that would, for profit, take away our good nutrition, beleager us with ill-health for the sake corporate profit. Bring personal resolve to the top of the list of activities that better our own health and the health of our children, and their children. The government can't/won't/shouldn't be asked to legislate this, it is our own personal task.

providing whole fruit

substituting vegetables

References 1. Nagel G, and Linseisen, J. et al. Dietary beta-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Breast Cancer Research and Treatment. 2010;119(3):753-65. 2. Basic Report: 11485, Squash, winter, butternut, raw. United States Department of Agriculture: 2013. 3. Whole Health Nutrition News. 2005.

Simple and Healthful: more please!

Butternut Squash soup

1.5 tbp unsalted butter1 Tbp olive oil

1 small onion, diced4 cups peeled diced butternut squash1 medium diced apple (any kind, peeling is optional)

1 medium carrot, diced4 3/4 cups chicken (or vegetable?) broth pepper for garnish

Serving size 4 (1.5 cups per serving)

In a medium pot over medium high heat, add olive oil and butter and stir until butter is completely melted.

Add diced onion and carrots. Stir for about one minute.Add diced apple and butternut squash and cook for about 3 minutes. Add in chicken broth and bring to a boil, then reduce heat. Continue boiling, uncovered, until the squash and apple are tender (approximately 25 minutes). Remove pot from heat. Transfer the vegetables with a slotted spoon into a food processor and puree in batches until it becomes smooth. If necessary, puree in several small batches. Leftover broth can be spooned into the puree until it is the consistency you like.

Serve in bowls and garnish with pepper and/ or sage. Pairs well with freshly toasted baguette. Enjoy.

The area just beneath the pale yellow skin of a butternut squash is loaded with nutrients and one of the best natural sources of vitamin A. Vitamin A is an antioxidant that exists in fruits and vegetables in the form of carotenoids. One of the common unoxygenated carotenoids is beta-carotene which is essential for vision and and may also reduce the risk of breast cancer in postmenopausal women(1).

A cup of butternut squash contains 745mg of vitamin A, 2.8g of dietary fiber and 3.1g of sugar(2). It is also low in sodium and does not contain cholesterol. In addition to vitamin A, this delicious winter squash also contains vitamin C, another antioxidant, essential to maintaining a healthy immune system. It is also rich in potassium. Give butternut squash a try and you will love it for life!

Fun fact: Butternut squash was once an essential part of certain Native American diets. It was so important that they buried butternut squash along with the dead to provide them nourishments on their final journey.

original images from arecipe contributed by Agnes Cheong

FYI, credit for this recipe is divided amoung the 8,760,000 hits for a google search of "butternut squash soup"

4

5

FacebookWindows of Susceptibility

TubeYou

http://www.webmd.com/cancer/features/seven-easy-to-find-foods-that-may-help-fight-cancer

Willing is not enough; we must do.” Goethe

Links to crossword and wordsearch puzzles tohelp reduce cancer risk

Several times recently, upon checking resources for this newsletter I have happened upon WebMD postings that really didnt mesh with the overwhelming mountain of scientific evidence and backing appear to

be, at best, a watered down statements. Instantly it occurred to me to check out the source of financial support for this large company (traded on the NYSE?) and it turned out to be Eli Lily. Anyone who has done research, collected data, knows unquestionably that bias is hard to avoid, thus, an unbiased relationship between a drug company and a news site seems far fetched . After checking on wikppedia I found this little note. " Allegations have been made that WebMD biases readers towards using drugs sold by their pharmaceutical sponsors in cases in which the drug is unnecessary.In February 2010, WebMD's financial relationship with drug maker Eli Lilly was investigated by Senator Chuck Grassley of Iowa."

?

COMMUNITYPARTNERS

Pink Ribbon GirlsCoffee Talk November 11, 2013

10:00 - 12:00pm

6

BCERPNovember Meeting

Magnificent scenery

Stage IV Coffee Talk 9444 Civic Centre Bvld, West Chester, OH 45069

CLUEsAcross

Vitamin D, health

UNIVERSITY OF

CincinnatiDept of Env Hlth

and cancer risk

1. In adults vitamin D deficiency leads to softening of the bones and _______ of the spine,2. Overall this vitamin is very important in the health of our _____,3. As with all research that on vitamin D has opinions on ____ sides,4. Phosphorus and _______ are regulated in part by calcitriol,5. The impact of the vitamine D receptor is seen in ____ proliferation and cell differentiation,6. Vitamin D deficiency causes its greatest damage in ________,7. A dietary source of vitamin D3 is in oily ____,8. Vitamin D impacts the immune system and thus relates to general ______ and cancer,9. Calcidiol is converted to calcitriol which is an active _______,10. By binding to a vitamin D receptor calcitriol becomes important __ modulating the expression of calcium binding proteins,11. Calcium binding proteins are important elements in absorbing calcium from the _________,

7

BreastCancerRisk

Windows ofSusceptibility

ANSWERS

Down

12. Synthesis of vitamin D occurs when the skin is hit by UV _____ from the sun,13. Vitamin D deficiency is still the ____ cause of rickets among young infants,14. Some genetic diseases _____ vitamin D deficiency,15. Cholecalciferol is the chemical name for the precursor of _______ D,16. Low vitamin D levels are associated with some cancers and ____ outcomes in other cancers,.

1. There is a close relationship between vitamin D and ______ risk,2. As with most hormones too ____ levels of vitamin D can be harmful,3. Neuromuscular and _______ functions are affected by calcitriol,4. Skin melanin content contributes to the ____ chance of a vitamin D overdose,5. Cholecalciferol known as vitamin D3 is converted to calcidiol by this organ,6. Low levels of sun exposure can be associated with ___ blood levels of vitamin D,7. Vitamin D is often added to staple foods such as ____ to ensure addequate intake,8. Within the nuceli of cells there is a vitamin D _________,9. Osteomalacia is a disease resulting from vitamin D deficiency in adults and in children causes _______,10. About 90 percent of our vitamin D is made in our ____,11. Giving the name vitamin to vitamin D is a little bit of a misnomer since the body can __________ it,12. Vitamin D deficiency has been linked to increased risk of _____ infections,

play this puzzle onlineabout apples and health

8

nutrient denSe f d

i cal rS o

:1 77nutrient S

9

most data derived from:http://www.ars.usda.gov/is/ar/archive/jun02/lyco0602.htm

77

morenutrient dense

:1 536

nutrient S57% fat

highly inflammatory8900mg Omega 6 (not good)

sodium, magnesium, potassiumphosphorus, folate, niacin,

riboflavin, vit C

i cal rS o

536

lessnutrientdense

100 CALORIES OF CHIPS 100 CALORIES OF PEAS

vit K, C, A, thiamin, folate,fiber Peas have polyphenol called

coumestrol which may lower risk of stomach cancer and has key

antioxidant and anti-inflammatory benefit, and phytonutrients called

saponins which coupled with ferulic acid and caffeic acid and

catechin and epicatechin, in other foods, may have great health

benefit, and even better - the crop is environmentally friendly

SOY CAROTENOIDS KALE BOILING WWIIBRASSICA RECEPTOR FRUIT DOUBLESUPPLEMENTS NEW EVIDENCE ENVIRONMENTAL

Nutrition, health

BreastCancerRisk

Windows ofSusceptibility

UNIVERSITY OF

CincinnatiDept of Env Hlth

and reducing breast cancer risk

Word searchsfor better health

WordsWords

L K D K I Y M X L A P T U J R J

A Y V T L I S G F C X T D X O X

T A F F I G U Q J I E B Z V T P

N I G W V S P C W S Y D K F Y T

E Y W S P V P A P S O E I P W E

M K G M Y P L R R A S Z P E V L

N E O S D Q E O O R I F N I F P

O Q Q E O K M T T B Y B D B R I

R Z U I U V E E P I S E F O U U

I E K C B C N N E D N I C I I K

V L B B L O T O C C D M E L T Q

N A M R E S S I E M A T K I L C

E K J Y P N D D R U G V G N N J

N K Q O G W T S L X L S I G Q Z

10

SOYCAROTENOIDS

KALE

BOILINGWWII

BRASSICA

RECEPTOR

FRUIT

DOUBLE

SUPPLEMENTS

NEW

EVIDENCE

ENVIRONMENTAL

would well be eaten with awareness since it has some mild estrogenic properties. are pigments in food, often red, orange or yellow color, and are helpful in

cancer fighting and risk reduction (this does not include Skittles and M&M). is a great source of carotenoids like vitamin A and K, it has plenty of lutein and

zeaxanthin, calcium and magnesium. reduces some nutrients in food, as opposed to microwaving, steaming or stirfrying.

saw encouragement of individuals to plant a "victory garden" with kale because of its high nutrient value.

is the name of the family of vegetables that includes kale, broccoli, kai-lan, cabbage, brussels sprouts, collard greens and others that have great health beneft.

Estrogen-receptor-negative cancers benefit more from a vegetable filled diet than estrogen-receptor-positive breast cancers.

provides great benefits for overall health, but benefits for reducing cancer risk by eating vegetables is even greater.

the benefits of healthful eating. Eating fewer foods with animal fats and transfats helps lower the risk of heart disease stroke and diabetes, as well as cancer.

A general rule is that eating your nutrients (vitamins minerals phytochemicals) as food is more beneficial than taking them as tablets. All the subtle interations are still mostly unknown.

cases of breast cancer in 2011 was over 200,000.

grows that links environmental exposure to breast cancer risk.

exposure is defined liberally and broadly to include chemicals, physical agents and mental and physical activity and life style choices (including food and exercise).

Words and comments

L K D K I Y M X L A P T U J R J

A Y V T L I S G F C X T D X O X

T A F F I G U Q J I E B Z V T P

N I G W V S P C W S Y D K F Y T

E Y W S P V P A P S O E I P W E

M K G M Y P L R R A S Z P E V L

N E O S D Q E O O R I F N I F P

O Q Q E O K M T T B Y B D B R I

R Z U I U V E E P I S E F O U U

I E K C B C N N E D N I C I I K

V L B B L O T O C C D M E L T Q

N A M R E S S I E M A T K I L C

E K J Y P N D D R U G V G N N J

N K Q O G W T S L X L S I G Q Z

11

RELEASE STRESS

REDUCE CANCER RISK

GAIN STRENGTH

WORKOUTTIPs

Work with a buddy (joy and misery love company) A friend can inspire you to go forward and you can reciprocate

Set goals (both realistic and unrealistic) A goal that you may never reach is exhilarating but needs to carry with it smaller steps. Stretches and holding poses for slightly more each time can give one a sense of progress Journal your success (and your failures) Chronicle your workouts, the increase in duration of yoga poses, the number of workouts per week, the number of minutes spent in a works, measurements of progress with flexibility and strength, weight loss

Plan ahead (with flexible alternatives) Being willing to compromise, change plans, and adapt keeps one's spirit and enthusiasm for yoga alive and allows for release of anxiety when an workout gets put on the sidelines for other duties. But consider finding an alternative site, place, or quiet niche at a later time

Keep moving forward (allow for ups and downs) Record your progress over the months, as it is truly gratifying and inspirational, especially with your yoga buddies, to compare and encourage and inspire continued commitment to better physical health.

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