CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY

CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY

EYE CARE

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OCULAR INFLAMMATION AND UVEITIS

CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY

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This is an excerpt from a series of interactive slide decks that were transferred to the program Articulate. The deliverable included instructions for animation as well as a voiceover script. While the interactive product is no longer available as a writing sample, this excerpt is offered to demonstrate PowerPoint skills.

CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY

Treatment of Uveitis

CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY

Treatment of Uveitis Goals of Therapy

● Suppress inflammation

● Avoid complications

Review of Ophthalmology. http://www.revophth.com/content/d/features/i/1305/c/25117/

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CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY

Treatment of Uveitis

● Cycloplegics– Dilate the pupil– Relieve some pain– Prevent anterior synechiae

● Antimicrobials – Used in infectious uveitis

● Corticosteroids– The gold standard of treatment– Block the inflammatory cascade at its origin– Modulate other inflammatory mediators

Allergan. http://www.allergan.com/assets/images/US/products/pred_forte.jpg.

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Standard Treatments

CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY

Treatment of Uveitis

● Corticosteroid Delivery– Topical

– Periocular

– Systemic

– Intravitreal Triamcinolone injections

Implantable devices

(eg, Retisert®, Ozurdex™)

Mohawk Valley Retina. http://www.mvretina.com/education/images/injws_000.jpg.

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Standard Treatments

CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY

Treatment of Uveitis

● Antimetabolites – Azathioprine (Imuran)– Methotrexate– Mycophenolate (CellCept®)

● T-cell inhibitors – Cyclosporine – Tacrolimus (Prograf®)

● Cytotoxic agents – Cyclophosphamide (Cytoxan)– Chlorambucil (Leukeran®)

http://www.drug3k.com/img2/imuran_10554_5_(tb)_.jpghttp://www.drug3k.com/img2/cellcept_10987_5_%28big%29_.jpg.

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Other Treatments

CONFIDENTIAL – FOR INTERNAL TRAINING PURPOSES ONLY

Treatment of Uveitis

● Anti-tumor necrosis factor-α – Adalimumab (Humira®)

– Infliximab (Remicade®)

● Anti-interleukin-2 receptor– Daclizumab (Zenapax)

● Anti VEGF – Bevacizumab (Avastin) or

– Ranibizumab (Lucentis®) for refractory CME and neovascular complications of uveitis

Ophthotech Corporation.http://www.ophthotech.com/wp-content/gallery/e10030/e10030c_lg.jpg

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Other Treatments