ethics of germline gene editing in non-human primates (mildred cho)
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Htglks jf
Dhri`lch Dhch
Hmltlcd
lc Cjc‒Guioc Rrlioths
Il`mrhm Kgj
[tocfjrm Khcthr fjr Eljihmlko` Htglks
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Dhch hmltlcd
lc
ijcahys
Fhe 52?=
Mhk 52?=
Kycjij`dus
Dhri`lch
KUL[RU Rpor‒
&
Uod?
(Cr2e?)
Clu, \ ht
o`.
Kghc, \ ht o`.
Ior 52?= Ughsus &
Kycjij`dus
]O@HCs IHKR5 @lu, G ht o`.
Nuc
52?= Kycjij`dus ]O@HCs IHKR5 @lu,
^ ht o`.
Fhe 52?8 Kycjij`dus KUL[RU p8; Toc, G ht o`.
Opr 52?8 Ughsus KUL[RU MIM Kghc, \ ht o`.
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Htglko` kjcslmhrotljcs
Tgy dhri`lch dhch hmltlcd jf CGRs:
• Dhch hmltlcd
vs jtghr
trocsdhclk
ihtgjms
‛ Jc‒tordht / jff ‒tordht iutotljcs
‛ Rjthctlo` fjr cu`` iutotljcs, iu`tlp`hx dhchtlk
ioclpu`otljc
• Dhri`lch vs sjiotlk dhchtlk ijmlflkotljcs
‛ Erhhmlcd fjr
guioc
mlshosh
ijmh`s
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• Cjc‒guioc
prlioth
ijmh`s
jf
guioc
mlshosh
‛ Churjpsykglotrlk ocm churjmhdhchrotlvh mlshoshs (GM, Uhtt [ycmrjih)
‛ Kockhr ‛ Liiuclty
‛ Guioc‒`lchodh sphklflk dhchs
• @ocduodh• Kjdcltljc
• Jtghr ehgovljro` trolts
Htglko` kjcslmhrotljcs
Tgy dhri`lch dhch hmltlcd jf CGRs:
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Htglko` kjcslmhrotljcs
Ulsas ocm
ehchflts
• ]gh utl`ltorloc vlhw> whldglcd `lah`lgjjm jf
ehchflt wltg
rlsa
‛ Ulsas tj CGRs
‛ Ulsas tj guiocs
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52?? LJI/CUK
rhpjrt
• Kglipoczhhs lc Eljihmlko` ocm Ehgovljro`
Uhshorkg> Osshsslcd
tgh
Chkhsslty
‛ Eljihmlko` rhshorkg krlthrlo prjpjshm>
• Cj jtghr sultoe`h ijmh` ovol`oe`h
• Uhshorkg koccjt
eh
phrfjrihm
htglko``y
jc
guioc
suenhkts
• Fjrdjlcd kglipoczhh rhshorkg wl`` s`jw jr prhvhct
omvockhihcts tj
prhvhct
jr
trhot
`lfh
‒tgrhothclcd
jr
mhel`ltotlcd kjcmltljcs
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Htglko` kjcslmhrotljcs
Ulsas ocm
ehchflts
• Eljihmlko` rhshorkg uslcd stjrhm soip`hs ls
hxhipt
• Oclio`s iust eh iolctolchm hltghr lc
htgj`jdlko``y opprjprloth pgyslko` ocm sjklo`
hcvlrjcihcts jr lc coturo` goeltots
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52?? LJI/CUK
Uhpjrt
• ‐…utl`ltorloc nustlflkotljcs fjri port jf tgh
rotljco`h fjr
kjctlcuhm
rhshorkg
lc
oclio`s1
tgot ls, oclio`s orh suenhkthm tj rlsa fjr tgh
ehchflt jf guiocs, ocm nustlflkotljc rh`lhs jc
osshssihcts tgot
tgh
ehchflts
dolchm
frji
rhshorkg jc oclio`s orh sufflklhct tj jutwhldg
tgh goris koushm lc tgh prjkhss.’
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52?? LJI/CUK
Uhpjrt
• ‐Rurh`y utl`ltorloc nustlflkotljcs orh thiphrhm
lc oclio`
rhshorkg
tgrjudg
pj`lky
rhqulrhihcts fjr guioch trhotihct ocm tgh ush jf opprjprloth sphklhs ocm ilclio`
cuiehr jf
oclio`s.’
• ‐Furtghrijrh, lipjslcd rhqulrhihcts fjr nustlfylcd tgh ush jf gldghr sphklhs ls oc
lip`lklt rhkjdcltljc
tgot
tgh
ush
jf
gldghr
oclio`s kjihs ot gldghr ijro` kjsts.’
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52?? LJI/CUK
Uhpjrt
• ‐Tgl`h tgh kglipoczhh gos ehhc o vo`uoe`h
oclio`
ijmh`
lc
post
rhshorkg,
ijst
kurrhct
ush
jf kglipoczhhs
fjr
eljihmlko`
rhshorkg
ls
ucchkhssory, eoshm jc tgh krlthrlo hstoe`lsghm ey tgh kjiiltthh, hxkhpt pjthctlo``y fjr twj kurrhct
rhshorkg ushs>’
‛ O `lilthm cuiehr jf ijcjk`jco` octlejmlhs o`rhomy lc tgh mhvh`jpihcto` plph`lch
‛ Mhvh`jpihct jf prjpgy`oktlk ghpotltls K vlrus (cj
kjcshcsus jc
kjiiltthh)
‛ O chw, hihrdlcd, jr rhhihrdlcd mlshosh ioy rhqulrh futurh ush jf tgh kglipoczhh
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Osshsslcd `lah`lgjjm
jf
ehchflt
• Uh`hvockh tj guioc mlshosh, h.d.,
‛ CGR rhshorkg gos cjt prhmlkthm guioc rhspjcsh tj vlro` vokklchs
wh``
‛ Liiuch systhis vory drhot`y ehtwhhc sphklhs (Vo``hcmhr & Il``hr 52?;)
‛ [jih churjpsykglotrlk kjcmltljcs jf lcthrhst (skglzjpgrhclo,
outlsi)
orh
suddhsthm
tj
eh
guioc
‒
sphklflk ocm ossjklothm dhchs ucmhr rhkhct pjsltlvh sh`hktljc (h.d., ]hffhr ocm [hihcmhfhrl 52?5)
‛ @lilthm kjdcltlvh ehgovljro` thsts fjr iorijshts, sio``
ghom slzh
ioahs
liodlcd
mlfflku`t
(Kgoc,
522
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Liprjvlcd `lah`lgjjm
jf
ehchflt
• [phklhs‒sphklflk dhcjilk vorlotljc (Vo``hcmhr & Il``hr
52?;) ‛ Dhchtlk vorlotljc lc CGRs ls iukg ijrh hxthcslvh
tgoc vorlotljc lc guiocs, eut `hss wh``‒ucmhrstjjm
‛
]ghrh
orh
vhry
fhw
trocs‒
sphklhs
pj`yijrpglsis
lc
guiocs ocm kglipoczhhs (Gjmdalcsjc & Hyrh‒To`ahr
52?2)
‛ Lip`lkotljcs jf vorlotljc lc kytjkgrjih R=82 dhchs
ocm hffhkts jc mrud ihtoej`lsi lc CGRs cjt wh``‒acjwc
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Liprjvlcd `lah`lgjjm
jf
ehchflt
• [tumy mhsldc ([hco ht o`. 5224)
‛ Oclio` stumlhs
jf
mrud
jr
elj`jdlko`
trhotihcts
orh jfthc sukkhssfu` wghrh sueshquhct guioc
stumlhs orh cjt
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Liprjvlcd `lah`lgjjm
jf
ehchflt
• Oclio` stumlhs
tgot
skjrh
gldghr jc stumy quo`lty
kghka`lsts prjmukhm
suestoctlo``y `jwhr
hstlioths jf hffhkt slzh
tgoc `jwhr skjrlcd
stumlhs ([hco ht
o`.
5224)
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Liprjvlcd `lah`lgjjm
jf
ehchflt
• Cjc‒rocmjilzhm stumlhs
govh gldghr
hstlioths
jf
hfflkoky tgoc rocmjilzhm
stumlhs
• [tumlhs wltgjut e`lcmhm
jutkjih osshssihct govh gldghr hstlioths jf
hfflkoky tgoc e`lcmhm
stumlhs ‛ (voc mhr Tjrp ht o` . 5224)
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Kjck`usljcs• Dhri`lch dhch hmltlcd jf CGRs rolshs slil`or
htglko` lssuhs
os
tgjsh
rolshm
ey
jtghr
trocsdhclk
ihtgjms
• Gjwhvhr, dhch hmltlcd gos tgh pjthctlo` tj
erjomhc
tgh
orroy
jf
CGR
ijmh`s
jf
guioc
mlshosh tj lck`umh ijrh mhel`ltotlcd pghcjtyphs
• [ukg lcmuktljc jf shrljus mlshosh koc jc`y eh
nustlflhm
ey
korhfu`
ocm
rho`lstlk
osshssihct
jf
ehchflts `lah`y tj okkruh frji CGR ijmh`s ocm ush jf rldjrjus stumy mhsldc