ERGOgenic Aids

Prevalence of Substance Abuse in Sports Marion JonesMarion Jones

first sample + for EPO, 2 first sample + for EPO, 2ndnd sample sample negative; exonerated…negative; exonerated……the search for better tests…the search for better tests

Justin Gatlin….testosteroneJustin Gatlin….testosterone Bonds, McGuire, Palmeiro, Canseco, ArodBonds, McGuire, Palmeiro, Canseco, Arod Ben JohnsonBen Johnson Cyclists: many, including Floyd LandisCyclists: many, including Floyd Landis Lyle AlzadoLyle Alzado

Prevalence of Substance Abuse in Sports Most studies have focused on alcohol and Most studies have focused on alcohol and

steroid use:steroid use: Alcohol use: 55-90+ % of high school athletes, Alcohol use: 55-90+ % of high school athletes,

over 80% of college athletes.over 80% of college athletes. Performance-enhancing drugs: up to 5% of Performance-enhancing drugs: up to 5% of

high school and college athletes report using high school and college athletes report using them (higher % among elite athletes, especially them (higher % among elite athletes, especially in past).in past).

Why Athletes and Exercisers Take Drugs * Physical reasons include wanting to:* Physical reasons include wanting to:

enhance performanceenhance performance treat injurytreat injury look betterlook better control appetite and lose weightcontrol appetite and lose weight

Why Athletes and Exercisers Take Drugs * Psychological reasons include wanting to:* Psychological reasons include wanting to:

escape from unpleasant emotions or stressescape from unpleasant emotions or stress build confidence or enhance self-esteembuild confidence or enhance self-esteem get buzzed/wasted or seek fun/ excitementget buzzed/wasted or seek fun/ excitement ““Winning”Winning”

Social Reasons include:Social Reasons include: emulating athletic heroesemulating athletic heroes peer pressurepeer pressure

Ergogenic Aids - Definition

Any substance or treatment that Any substance or treatment that either directly improves either directly improves physiological variables associated physiological variables associated with exercise performance or with exercise performance or removes subjective restraints that removes subjective restraints that may limit physiologic capacitymay limit physiologic capacity

Ergogenic Aids

TypesTypes PsychologicalPsychological MechanicalMechanical PharmacologicalPharmacological PhysiologicalPhysiological NutritionalNutritional

Doping Definition (USOC)

“…“…..the administration of or use by a ..the administration of or use by a competing athlete of any substance foreign competing athlete of any substance foreign to the body or of any physiological to the body or of any physiological substance taken in abnormal quantity or substance taken in abnormal quantity or taken by an abnormal route of entry into the taken by an abnormal route of entry into the body, with the sole intention of increasing body, with the sole intention of increasing in an artificial manner his/her performance in an artificial manner his/her performance in competition is regarded as doping..”in competition is regarded as doping..”

Pharmacological Agents

Over the Counter Drugs:Over the Counter Drugs: Caffeine, Nicotine, Melatonin….etc;Caffeine, Nicotine, Melatonin….etc;

““Recreational” DrugsRecreational” Drugs:: Alcohol, Marijuana, Cocaine…….etc;Alcohol, Marijuana, Cocaine…….etc;

Prescription DrugsPrescription Drugs:: Anabolic Steroids, BenzodiazepinesAnabolic Steroids, Benzodiazepines, , Beta-Beta-

Adrenergic Agents…….etc;Adrenergic Agents…….etc;

Anabolic Steroids

Testosterone (must be injected or it will be Testosterone (must be injected or it will be destroyed by digestive enzymes)destroyed by digestive enzymes)

Anabolic Androgenic Steroids (AAS)Anabolic Androgenic Steroids (AAS) synthetic drugs designed to mimic the effects synthetic drugs designed to mimic the effects

of testosterone; taken orally or injectedof testosterone; taken orally or injected Human Growth Hormone (anabolic)Human Growth Hormone (anabolic)

used like steroids to increase muscle massused like steroids to increase muscle mass Beta Adrenergic Agents (Clenbuterol)Beta Adrenergic Agents (Clenbuterol)

Ergogenic Effect and Side Effects of AAS Increase muscle mass; decrease body fat; Increase muscle mass; decrease body fat;

improve strength even without trainingimprove strength even without training Side Effects (AAS):Side Effects (AAS):

acne; hair loss; male secondary sex characteristics like acne; hair loss; male secondary sex characteristics like deepening of the voice;deepening of the voice;

increased aggression, depression, hostility, suicide increased aggression, depression, hostility, suicide attempts, tendency to commit violent acts;attempts, tendency to commit violent acts;

cardiovascular disease (elevated cholesterol, blood cardiovascular disease (elevated cholesterol, blood pressure)pressure)

severe liver damage;tumors (Alzado)….. etcsevere liver damage;tumors (Alzado)….. etc

Effects and Side Effects of Growth Hormone hormone secreted by pituitary gland; stimulates hormone secreted by pituitary gland; stimulates

bone and muscle growth; effects protein, bone and muscle growth; effects protein, carbohydrate and fat metabolismcarbohydrate and fat metabolism

currently little data showing ergogenic effects currently little data showing ergogenic effects beyondbeyond the effect generated by strength training the effect generated by strength training

may lead to diabetes; thickening of soft tissue in may lead to diabetes; thickening of soft tissue in face, hands and feet; enlargement of organs such face, hands and feet; enlargement of organs such as liveras liver

Effects and Side Effects of Clenbuterol (asthma; illegal in U.S.) increase lean muscle mass and strength; increase lean muscle mass and strength;

decrease body fat decrease body fat less potent than anabolic steroids less potent than anabolic steroids side effects:side effects:

tachycardiatachycardia muscle tensionmuscle tension headaches and dizzinessheadaches and dizziness

Physiological Agents

Bicarbonate LoadingBicarbonate Loading Blood DopingBlood Doping Erythropoietin (EPO)Erythropoietin (EPO) Altitude TrainingAltitude Training GlycerolGlycerol Phosphate LoadingPhosphate Loading

Erythropoietin - EPO

Hormone produced by kidneys to stimulate Hormone produced by kidneys to stimulate the bone marrow to produce red blood cellsthe bone marrow to produce red blood cells

Has same effect as “blood doping” and Has same effect as “blood doping” and altitude training (more efficient use of Oaltitude training (more efficient use of O2))

IllegalIllegal Dangers: increased blood viscosity, clotting Dangers: increased blood viscosity, clotting

potential, increased risk for stroke and heart potential, increased risk for stroke and heart failure, or pulmonary edemafailure, or pulmonary edema

Nutritional Agents / Supplements

Amino Acid SupplementationAmino Acid Supplementation Bee PollenBee Pollen Carbohydrate LoadingCarbohydrate Loading CarnitineCarnitine Coenzyme Q-10Coenzyme Q-10 Creatine PhosphateCreatine Phosphate Water or Special BeveragesWater or Special Beverages

Ergogenic Effect Supported by Research Legal Supplements / BehaviorsLegal Supplements / Behaviors

Creatine Phosphate Creatine Phosphate (equivocal)(equivocal)

CaffeineCaffeine Altitude training Altitude training (equivocal)(equivocal)

“There is still no sphere of nutrition in which faddism,

misconceptions, ignorance, and quackery are more obvious than

in athletics..”

(M.H. Williams in Nutrition for Fitness and Sport, 4th ed., 1995)