epidemiologia e meccanismi patogenetici dell’interazione
TRANSCRIPT
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Epidemiologia e meccanismi patogenetici dell’interazione obesità-cancro
Francesco S. Papadia, MD, FACS
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Riduzione dell’età di screening per CRC negli USA dai 50 ai 45 anni
“more than 1 in 10 colon cancers and nearly 1 in 4 rectal cancers will be diagnosed in people below the traditional screening age”
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Meccanismi biologici obesità-cancro
• 1) iperinsulinemia /IR e alterazioni insulin-like growth factor-I (IGF-I)
• 2) sintesi e metabolismo ormoni sessuali steroidei
• 3) infiammazione cronica subclinica e stress ossidativo
• 4) alterazioni microambiente/matrice
• 5) alterazioni del microbioma
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Alterata/ridotta produzione adiponectina
Infiammazione cronica subclinica
Alterato metabolismo steroidi
Insulinoresistenza-diabete
Alterazione microbioma
Dieta ricca grassi insaturi
Alterazioni microambiente/matrice extracellulare
Promozione
progressione
↓ adiponectina
↑ estrogeni→ endometrio,Mammela post-menopausa
↑ permeabilità intestinale/traslocazione,
infiammazione cronica
↑ citochine pro-infiammatorie, stress
ossidativo, IR
↑ angiogenesi, infiammazione cronica, stress
ossidativo
↑ IGF, insulina, IGFR, mTOR
↑ IR, infiammazione cronica, substrati steroidei
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Grazie per l’attenzione!
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