elucidating the locking mechanism of peptides onto growing amyloid fibrils through transition path...

8
Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis Biophysical Journal Volume 103, Issue 6, Pages 1296-1304 (September 2012) DOI: 10.1016/j.bpj.2012.07.056 Copyright © 2012 Biophysical Society Terms and Conditions

Upload: laurence-harris

Post on 13-Dec-2015

218 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis

Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling 

Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis 

Biophysical Journal Volume 103, Issue 6, Pages 1296-1304 (September 2012)

DOI: 10.1016/j.bpj.2012.07.056

Copyright © 2012 Biophysical Society Terms and Conditions

Page 2: Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis

Figure 1

Biophysical Journal 2012 103, 1296-1304DOI: (10.1016/j.bpj.2012.07.056) Copyright © 2012 Biophysical Society Terms and Conditions

Page 3: Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis

Figure 2

Biophysical Journal 2012 103, 1296-1304DOI: (10.1016/j.bpj.2012.07.056) Copyright © 2012 Biophysical Society Terms and Conditions

Page 4: Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis

Figure 3

Biophysical Journal 2012 103, 1296-1304DOI: (10.1016/j.bpj.2012.07.056) Copyright © 2012 Biophysical Society Terms and Conditions

Page 5: Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis

Figure 4

Biophysical Journal 2012 103, 1296-1304DOI: (10.1016/j.bpj.2012.07.056) Copyright © 2012 Biophysical Society Terms and Conditions

Page 6: Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis

Figure 5

Biophysical Journal 2012 103, 1296-1304DOI: (10.1016/j.bpj.2012.07.056) Copyright © 2012 Biophysical Society Terms and Conditions

Page 7: Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis

Figure 6

Biophysical Journal 2012 103, 1296-1304DOI: (10.1016/j.bpj.2012.07.056) Copyright © 2012 Biophysical Society Terms and Conditions

Page 8: Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis

Figure 7

Biophysical Journal 2012 103, 1296-1304DOI: (10.1016/j.bpj.2012.07.056) Copyright © 2012 Biophysical Society Terms and Conditions