elsevier. Обзор · reaxys 2013 now reaxys sources relevant chemistry information from adjacent...
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Elsevier. Обзор
28 сентября 2016
Москва, Российская Федерация
Марат Фатхуллин
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количества опубликованных статей
и количества цитирований (в т.ч. и
по БД Scopus) введены в
государственные регулирующие
документы
Сравнительные данные
Scopus 24,169
БК 12,491
Scopus
7,410 (+78%)
БК
4,188
Scopus
6,740 (+97%)
БК
3,415
Scopus
4,436 (+50%)
БК
2,954
Scopus
7,684 (+90%)
БК
4,016
Физические науки Медицина Науки о жизни Социогум. науки
~12K названий
3,300 издательств
Еженедельное
обновление
~24K названий
>5,000 издательств
Ежедневное
обновление
Источник: Web of Science Real Facts, списки журналов Web of Science и Scopus April 2014)
Ближайший конкурент
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EMBASE IS AS COMPREHENSIVE AS POSSIBLE
PRESENTER | DATE | NAME OF PRESENTATION
Percentage of relevant articles retrieved
0 % 50 % 100 %
Eff
ort
/ t
ools
requir
ed
EMBASE
PUBMED
SOURCE
SCOPUS
TEXT MINING
Serving the life sciences space ADDRESSING KEY CHALLENGES ACROSS THE R&D VALUE CHAIN
Characterize & discover
molecules
Identify & confirm lead
compounds
Translate preclinical
data in humans
(Translational)
Characterize
targets & analyze
disease pathways
Monitor drug
adverse events &
real-world evidence
data in literature
Integrate the
world of data &
solutions
Drug Candidate Selection Go-No Go Decision
Preclinical Data Validation Managing risk
Text Mining & Data Integration
Discovery Pre-clinical Clinical Post-launch
Search full-text, peer-
reviewed journal
articles
Largest database for access
to abstract & citation data
Broader full-text
indexing of biomedical
content
7
8
Choosing one wrong target costs time(2½yrs) & money ($3.5M) and has more substantial repercussions ($254M and 13yrs lost) in the long term. Reducing the risk by increasing knowledge around targets from the start is pivotal in drug discovery.
FINDING GOOD TARGETS REMAINS A CHALLENGE
30% of Phase II failures from 2008-2010 were
related to validated targets
“Large numbers of failures are occurring with drugs
that have novel mechanisms of action in areas of high unmet medical need..”
REAXYS
UNFOCUSED RESULTS
BIBLIOGRAPHIC
APPROACH
USE-CASE DRIVEN
ACROSS TIME/LITERATURE
ESSENTIAL TITLES
Structured to help you search
50,000,000 RESULTS RETURNED
FURTHER SEARCH
NEEDED
CATALOGUED AND TAXONMISED BY CHEMISTS FOR CHEMISTS
OTHER DATABASES
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RELEVANT ANSWERS
Extract title and abstract enabling
researchers to do extended bibliographic
search across all scientific domains.
Providing
access to journals you wouldn’t consider
searching for.
Facts
Facts
Facts
15,973 PERIODICALS COVERING
• AGRICULTURAL AND BIOLOGICAL SCIENCES
• BIOCHEMISTRY, GENETICS AND MOLECULAR BIOLOGY
• CHEMICAL ENGINEERING
• CHEMISTRY
• DENTISTRY
• EARTH AND PLANETARY SCIENCES
• ENERGY
• ENGINEERING
• ENVIRONMENTAL SCIENCE
• IMMUNOLOGY AND MICROBIOLOGY
• MATERIALS SCIENCE
• MEDICINE
• NEUROSCIENCE
• PHARMACOLOGY, TOXICOLOGY AND PHARMACEUTICS
• PHYSICS AND ASTRONOMY
• VETERINARY
REAXYS 2013 NOW REAXYS SOURCES RELEVANT CHEMISTRY INFORMATION FROM ADJACENT SCIENTIFIC
FIELDS, BRINGING THEM WITHIN REACH OF THE CHEMISTRY RESEARCHER
A universe of chemistry information
CHEMISTRY RESEARCHER
CHEMISTRY
• 400 CORE JOURNALS
• RELEVANT CHEMISTRY PATENTS
• HISTORICAL CHEMISTRY DATA (FROM 1771)
10
MANY WAYS TO ASK YOUR QUESTIONS
Reaxys home page:
Data search
form by subject
Perform a
literature
search
Open a
structure
search form
11
Open Reaction
search form
UNDERSTAND
EXPERIMENT REPORT &
COMMUNI-CATE
Search using
chemical
identifiers
Ask Reaxys, a quick
‘concept search’
Browse database via
taxonomies rather
than search
database
Chemistry as the organizing principle
Reaxys design
Physical Data
Bioactivity Data
Spectra
Natural Product
Physical Data
Spectra
Bioactivity Data
Natural Product
Reaxys
With experimental data from journal articles and
patents
Reaxys is built
Chemistry as the Organizing Principle
Chemical Structures
Chemical Syntheses
Physicochemical Properties
Pharmacology
Reaxys excerpts
all relevant data
even from
footnotes and text
PROPERTIES OF COMPOUNDS
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Reaxys
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… But it's not that simple, medicinal chemists for instance need to collect, organize and compare information from different sourceS… this is time consuming and error prone
?
? ?
?
… But it's not that simple, medicinal chemists for instance need to collect, organize and compare information from different sourceS… this is time consuming and error prone
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And to Make a decision on which experiment to do, you want to organize your content, normalize and compare, to understand which compound interacts with which target and trigger which biological effect—that's a lot of manual work!
DR. OLIVIER BARBERAN | RMC 2014| ELSEVIER
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