introduction to reaxys
DESCRIPTION
These are the slides for the October 15, 2013 webinar.TRANSCRIPT
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Christine FlemmingElsevier Product Training ManagerOctober 15, 2013
INTRODUCTION TO
REAXYS
Webinar presented October 15, 2013
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Look for the slides and webinar recordings on SlideShare and YouTube
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AGENDA
• INTRODUCTION
• THE REAXYS CHEMISTRY DISCOVERY ENGINE
• DEMO
• QUESTIONS
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• THE WORKFLOW SOLUTIONS THAT LEADING CHEMISTS PREFER TO USE• 95% OF THE LARGEST PHARMACEUTICAL R&D
ORGANIZATIONS AND 70 OF THE TOP 100 CHEMISTRY UNIVERSITIES HAVE ALREADY CHOSEN REAXYS
• POWERFUL SOLUTIONS ACROSS THE ENTIRE CHEMISTRY WORKFLOW• DESIGNED BY CHEMISTS TO HELP CHEMISTS OF ALL
KINDS IN ALL SECTORS, ADVANCE MORE QUICKLY AND CONFIDENTLY THROUGH THEIR RESEARCH
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ACADEMIA & GOVERNMENTAcademic ResearchersPrincipal InvestigatorsPharmacologistsMedical ResearchersRegulatory AffairsClinical/Medical Researchers
CORPORATEMolecular BiologistsBio-informaticiansChemistsChem-informaticiansSafety PhamacologistsPhamacokineticistsRegulatory AffairsClinical ResearchersMedical AffairsPharmacovigilance
SERVING THE WHOLE LIFE SCIENCES COMMUNITY PART OF LIFE SCIENCE SOLUTIONS
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A SUITE OF INTEROPERABLE, DOMAIN-SPECIFIC, DECISION SUPPORT TOOLSPART OF LIFE SCIENCE SOLUTIONS
TARGETINSIGHTS
PHARMAPENDIUM
EMBASE
QUOSA
PATHWAY STUDIO
REAXYS
REAXYS MEDICINAL CHEMISTRY
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Learn/act on pre-clinical &clinical data (translational)
POST LAUNCHDISCOVERY PRE-
CLINICAL CLINICAL
Extract value from R&D data through custom services
SUITE OF DECISION SUPPORT TOOLS ADDRESSING KEY USE CASES
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Identify, optimize and prioritize compounds
Professional Services
Characterize and discover molecules
Find and characterise targets
Understand Pathways/MoA
Organize and manage scientific literature
Post market tracking, Pharmaco-vigilance
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THE REAXYS CHEMISTRY DISCOVERY ENGINE
KEY FEATURES
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SUPPORTS ENTIRE WORKFLOW
ANSWERING YOUR QUESTIONS AT EVERY STAGE OF YOUR RESEARCH WORKFLOWSome of the key questions that Reaxys will help answer:
• Does a compound exist?• What is known about the compound?• Is this compound commercially available?• How to synthesize this compound?• What is known about this area of research?• Who else is working on this compound or
reaction type?
Reaxys gives relevant and actionable answers and allows you to move your research forward.
UNDERSTANDKnow and understand
what others have done and how.
Access the relevant and actionable information
quickly with a dedicated solution.
Discover information you didn’t
realize you were missing.
EXPERIMENTDesign experiments
without wasting time.
Get existing compounds or find out how to synthesize
them.
Use experimentally measured data to move your research forward
more quickly.
REPORT & COMMUNICATEShare results with your
peers.
Gain insight and move on to new projects with
confidence.
Accelerate innovation and research progress.
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WHAT ARE SOME OTHER QUESTIONS REAXYS CAN ANSWER?
“How can I find reactions where an aryl halide has been transformed into an aryl ketone?”
“How can I search for superconducting substances containing Barium, Yttrium, and Copper?”
“How can I get pharmacokinetic data (Cmax or AUC) for substances with this substructure that have undergone preclinical or clinical evaluation?”
“I have a list of natural products and I’d like to know if any of them contain antimalarial activity. How can I do this in Reaxys?”
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Extract title and abstract enabling researchers to do extended bibliographic search across all scientific domains. Providing access to journals you wouldn’t consider searching for.
Facts
Facts
Facts
15,973 PERIODICALS COVERING• AGRICULTURAL AND
BIOLOGICAL SCIENCES
• BIOCHEMISTRY, GENETICS AND MOLECULAR BIOLOGY
• CHEMICAL ENGINEERING
• CHEMISTRY
• DENTISTRY
• EARTH AND PLANETARY SCIENCES
• ENERGY
• ENGINEERING
• ENVIRONMENTAL SCIENCE
• IMMUNOLOGY AND MICROBIOLOGY
• MATERIALS SCIENCE
• MEDICINE
• NEUROSCIENCE
• PHARMACOLOGY, TOXICOLOGY AND PHARMACEUTICS
• PHYSICS AND ASTRONOMY
• VETERINARY
REAXYS 2013
NOW REAXYS SOURCES RELEVANT CHEMISTRY INFORMATION FROM ADJACENT SCIENTIFIC FIELDS, BRINGING THEM WITHIN REACH OF THE
CHEMISTRY RESEARCHER
A UNIVERSE OF CHEMISTRY INFORMATION
CHEMISTRY RESEARCHE
R
CHEMISTRY• 400 CORE JOURNALS• RELEVANT CHEMISTRY
PATENTS• HISTORICAL CHEMISTRY
DATA (FROM 1771)
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MANY WAYS TO ASK YOUR QUESTIONSHOME PAGE:
UNDERSTAND
EXPERIMENT
REPORT & COMMUNICA
TE
Data search form
by subject
Search using
chemical identifiers
Perform a literature
search
Open a structure
search form
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AUTOMATES THE UNDERLYING PROCESSES IN CREATING SYNTHESIS ROUTESAUTOPLAN:
UNDERSTAND
EXPERIMENT
REPORT & COMMUNICA
TE
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FIND MULTIPLE SYNTHESIS ROUTES TO THE NATURAL PRODUCT SHIKONIN
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POWERFUL FILTER TO FIND WHAT YOU WANT IN JUST A FEW CLICKSANALYSIS VIEW:
UNDERSTAND
EXPERIMENT
REPORT & COMMUNICA
TE
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ANALYSIS
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GATHER AND PREPARE THE INFORMATIONREPORTING:
UNDERSTAND
EXPERIMENT
REPORT & COMMUNICA
TE
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SHARE THE INFORMATIONREPORTING:
UNDERSTAND
EXPERIMENT
REPORT & COMMUNICA
TE
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CREATE A REPORT
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INTEGRATED. JUST HOW YOU LIKE IT
IN-HOUSE DATA: Seamless integration for maximized search efficiency
PUBCHEM: Includes biochem. & pharmaco information
COMMERCIAL AVAILABILITY: Data and purchasing possibilities
REAXYS APIs: Combine the quality data you get from Reaxys with in-house creativity to build new solutions tailor-made for your specific research interests
ELECTRONIC LAB NOTEBOOKS: Improve collaboration, minimize errors, save timeREAXYS STRUCTURE FLAT FILE: Incorporate information into data mining and internal search systems
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DEMO
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REACTION SEARCHING
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Find one-pot synthesis of spiro-oxindoles
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FIND ONE-POT SYNTHESIS OF SPIRO-OXINDOLES: RESULTS
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I would like to find patents containing information on the oxidative cleavage of c-c bonds (like those found in styrene) into carboxylic acids using manganese-containing catalysts.
Then I want to export the list in a PDF:
PATENTS
Reaction example:
Generalize the query
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245 reactions, like these, are retrieved:
Which ones use manganese-containing catalysts?
Use “Analysis View” to limit the list to 79 reactions with manganese-containing catalysts.
What type of reactions are they?
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Which Patent Assignees show up most frequently in this list of 79 reactions?
Who received patents with this type of reaction between 2000 – 2008?
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Limit the list to rections found in patents
And then export the list in various formats, such as PDF.
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SUBSTANCE SEARCHINGFinding a list of substances with the same biological activity
Find natural products with antimalarial activity
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THANK YOUANY QUESTIONS?
Please complete the survey that appears at the end of this webinarThank you!
Next webinar:
Tomorrow, Oct. 16, 2013Reaxys Medicinal Chemistry10:00 AM – 10:45 AM EDTRegistration link:
https://www3.gotomeeting.com/register/614421950