effect of lycopene on sflt-1/plgf ratio in pre …vaulinne basyir1, prima nanda fauziah2,...
TRANSCRIPT
Copyright © 2019.Vaulinne Basyir, [email protected]
EFFECT OF LYCOPENE ON sFlt-1/PlGF RATIO IN
PRE-ECLAMPSIA INDUCED PLACENTAL TROPHOBLAST CELLSVaulinne Basyir1, Prima Nanda Fauziah2, Yanwirasti4, Johanes C. Mose3, Fadil Oenzil4
1Department Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia 2Department of Medical Laboratory Technology, Faculty of Health, Universitas MH. Thamrin, Jakarta, Indonesia
3Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia4Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia
Corresponding Email : [email protected]
Lycopene, known to possess
antioxidant properties and to
maintain body stability in spite of
changes, is therefore a promising
agent to decrease preeclampsia risk.
METHOD
• This study aimed to observe
lycopene on sFlt-1/PlGF ratio in
placental trophoblast which is
induced by preeclampsia in vitro.
• Level of sFlt-1 and PlGF was
measured with ELISA method.
• Data was analyzed with T-test if
normally distributed, and Mann
Whitney test if not normally
distributed. Data was quantitavely
analyzed with ANOVA DMRT
(Duncans’s Multiple Range Test)
to determine the significance
among variables in each treatment
SPSS 14.
RESULT
In preeclampsia-induced trophoblast,
sFlt-1/PlGF ratio decreased (p<0,001)
after treated with lycopene of 15.625
μg/ml incubated for 24 hours.
Lycopene possess high antioxidant and
balance in angiogenesis factor that
plays role as precursor in scavenging
reactive oxygen and reduce free
radicals that recover trophoblast cells
induced by preeclampsia as indicated
by increase in PlGF level. Further
studies regarding the optimal
concentration of lycopene on embryo
cell for clinical trial, are encouraged.
REFERENCES1. Lyall F, Greer IA. 1996. The vascular endothelium in normal pregnancy and preeclampsia. J Reprod Fertil;1:107-16.
2. Vaulinne Basyir, Prima Nanda Fauziah, Yanwirasti, Johanes C. Mose, Fadil Oenzil. Effect of Lycopene In Decreasing MDA Levels In Preeclampsia-
Induced Trophoblast Cells. Journal of Pharmtech Research. 2017. Vol. 10(2):103-8.
BACKGROUND