e‑cell system array comparative genomic methods and … · 2012-10-29 · prominin‑1 (cd133):...

News 11/2012 Biomedicine

15

S. N. Arjunan, Osaka University, Japan; P. K. Dhar, University of Kerala, India; M. Tomita, Keio University, Fujisawa, Japan (Eds)

E‑Cell SystemBasic Concepts and Applications

The interdisciplinary field of molecular systems biology aims to understand the behavior and mechanisms of biological processes composed of individual molecular components. As we gain more qualitative and quantitative information of complex intracellular processes, biochemical modeling and simulation become indispensable not only to uncover the molecular mechanisms of the processes, but to perform useful predictions.

Features 7 Provides an overview of whole cell modeling and its fundamental concepts 7 Describes the Spatiocyte lattice‑based simulation method which is developed as a set of E‑Cell System plug in modules 7 Provides examples of actual model‑ing applications that use the E‑Cell System

Contents Introduction to Whole Cell Modeling.‑ Founda‑tions of E‑Cell Simulation Environment Architec‑ture.‑ Distributed Cell Biology Simulations with the E‑Cell System.‑ A Guide to Modeling Reac‑tion‑Diffusion of Molecules with the E‑Cell Sys‑tem.‑ A Model Library of Bacterial Chemotaxis on E‑Cell System.‑ Electrophysiological Simulation of Developmental Changes in Action Potentials of Cardiomyocytes.‑ Simulation of Human Erythro‑cyte Metabolism.‑ Dynamic Kinetic Modeling of Mitochondrial Energy Metabolism.‑ A Compu‑tational Model of the Hepatic Lobule.‑ Decoding the Signaling Mechanism of Toll‑Like Receptor 4 Pathways in Wild Type and Knockouts.‑ Modeling of Hsp70‑Mediated Protein Refolding.

Fields of interestMolecular Medicine; Biomedicine general

Target groupsResearch

Discount groupProfessional Non‑Medical

Due December 2012

2012. XIV, 180 p. 65 illus., 4 in color. (Molecular Biology Intelligence Unit, Volume 118) Hardcover7 approx. $189.00ISBN 978-1-4614-6156-2

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D. Banerjee, British Columbia Cancer Agency, Vancouver, BC, Canada; S. P. Shah, BC Cancer Research Centre, Vancouver, BC, Canada (Eds)

Array Comparative Genomic HybridizationProtocols and Applications

Contents Array Comparative Genomic Hybridization: An Overview of Protocols, Applications and Technology Trends.‑ Ultra Dense Array CGH and Discovery of Micro‑Copy Number Alterations and Gene Fusions in the Cancer Genome.‑ Epigenom‑ics: Sequencing the Methylome.‑ Application of Array Comparative Genomic Hybridization in Chronic Myeloid Leukemia.‑ The Use of Cytoge‑netic Microarrays in Myelodysplastic Syndrome Characterization.‑ CGH Protocols ‑ Chronic Lymphocytic Leukemia.‑ Analysis of Acquire Genomic Copy Number Aberrations and Regions of Loss of Heterozygosity in Acute Myelogenous Leukemia Fenomes using Affymetrix SNP 6.0 Arrays and Supporting Software Tools.‑ Clinical Applications of BAC Array‑CGH to the Study of Diffuse Large B‑Cell Lymphomas.‑ Genomic Pro‑filing of Mantle Cell Lymphoma.‑ Copy Number Analysis in EBV‑Positive Nodal Peripheral T‑Cell Lymphoma, Unspecified.‑ Mycosis Fungoides and Sézary Syndrome.‑ Array CGH Reveals Clonal Evolution of Adult T Cell Leukemia/Lymphoma.‑ Array‑CGH Analysis of Cutaneous Anaplastic Large Cell Lymphoma.‑ Genome Wide DNA‑Pro‑filing of HIV‑Related B‑Cell Lymphomas.‑ Array Comparative Genomic Hybridization in Osteosar‑coma.‑ Comparative Genomic Hybridization of Wilms’ Tumor.‑ Array‑CGH in Childhood MDS.‑ Non‑Familial Breast Cancer Subtypes.‑ Applica‑tions of Array‑CGH for Lung Cancer.‑ Array CGH in Brain Tumours.‑ Finding Common Regions of Alteration in Copy Number Data. [...]

Fields of interestHuman Genetics; Laboratory Medicine

Target groupsProfessional/practitioner


Due January 2013

2013. XX, 450 p. 34 illus., 16 in color. (Methods in Molecular Biology, Volume 973) Hardcover7 $139.00ISBN 978-1-62703-280-3

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A. Becker, University of Bremen, Germany (Ed)

Virus‑Induced Gene SilencingMethods and Protocols

Contents Virus‑Induced Gene Silencing (VIGS) in Plants – An Overview of Target Species and the Virus‑De‑rived Vector Systems.‑ Rationale for Developing New Virus Vectors to Analyze Gene Function in Grasses Through Virus‑Induced Gene Silenc‑ing.‑ Virus Induced Gene Silencing for Rice Using Agroinoculation.‑ Utilizing Virus Induced Gene Silencing for the Functional Characterization of Maize Genes During Infection with the Fungal Pathogen Ustilago maydis.‑ Analysis of Develop‑mental Control Genes Using Virus Induced Gene Silencing.‑ Virus Induced Gene Silencing in the Rapid Cycling Columbine Aquilegia coerulea ‘Origami’.‑ Virus‑Induced Gene Silencing of the Alkaloid‑Producing Basal Eudicot Model Plant Eschscholzia californica (California Poppy).‑ Virus‑Induced Gene Silencing Using Artificial miRNAs in Nicotiana benthamiana.‑ The Use of VIGS Technology to Study Plant‑Herbivore Interactions.‑ Virus‑Aided Gene Expression and Silencing Using TRV for Functional Analysis of Floral Scent‑Related Genes.‑ Virus‑Induced Gene Silencing in Soybean and Common Bean.‑ Func‑tional Genomic Analysis of Cotton Genes with Agrobacterium‑Mediated Virus‑Induced Gene Silencing.‑ Highly Efficient Virus‑Induced Gene Silencing in Apple and Soybean by Apple latent spherical virus vector and Biolistic Inoculation.‑ VIGS A Tool to Study Fruit Development in Solanum lycopersicum.‑ A Protocol for VIGS in Arabidopsis thaliana Using a “One‑Step” TYMV‑Derived Vector.‑ Virus‑Induced Gene Silencing in Strawberry Fruit.

Fields of interestHuman Genetics; Gene Expression



Due January 2013

2013. XVI, 240 p. 34 illus., 13 in color. (Methods in Molecular Biology, Volume 975) Hardcover7 $119.00ISBN 978-1-62703-277-3

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www.springer.com/978-1-4614-6156-2



Biomedicine springer.com/NEWSonline

16

M. Bennett, Brain & Mind Research Institute, Camperdown, NSW, Australia

Virginia Woolf and NeuropsychiatryThis book, written by one of the leaders in the field of the neurosciences, will give an explanation of the symptoms and eventual untimely suicide of one of literatures greatest authors; Virginia Woolf. The sources used are letters and statements from Woolf herself, the literature she wrote and com‑ments, letters and any other documentation that referred to her mental state and her medical status. The author will use current insight into depres‑sion, the mental consequences of child abuse and drug interactions/effects to illustrate this case study.

Features 7 A book that is suitable for a wide audi‑ence 7 An in depth analysis of one of literature's leading and most loved individuals 7 A unique insight into the mind

Contents 1. Sexual Abuse, Literary Genius and a Mind gone Awry. ‑ 2. The Development of Early 20th century Psychiatry and its Failure. ‑ 3. Freud, the Subconscious and Virginia Woolf. ‑ 4. Virginia Woolf ’s Suicide. ‑ 5. Brain Networks, Hormones and Genes implicated in Depression. ‑ 6. The Pa‑thology of Synapses in Brain Networks implicated in Depression. ‑ 7. On the Mechanism of Action of an Anti‑Depressant. ‑ 8. On the Identification of Drugs Modulating Epigenetic Mechanisms in Depression. ‑ 9. Brain Networks in Psychosis. ‑ 10. The Mind, Mental Illness and the Stream of Consciousness.

Fields of interestBiomedicine general; Neurosciences; Neurobiol‑ogy

Target groupsPopular/general


Due January 2013

2013. VIII, 217 p. 4 illus., 1 in color. Hardcover7 $49.95ISBN 978-94-007-5747-9

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M. Bina, Purdue University, West Lafayette, IN, USA (Ed)

Gene RegulationMethods and Protocols

Contents Gene Regulation.‑ Isolation of Nuclei for use in Genome‑wide DNase Hypersensitivity Assays to Probe Chromatin Structure.‑ DNase I Digestion of Isolated Nulcei for Genome‑Wide Mapping of DNase Hypersensitivity Sites in Chromatin.‑ Isola‑tion and Analysis of DNA Derived from Nucleo‑some‑Free Regions.‑ Acquisition of High Quality DNA for Massive Parallel Sequencing by in vivo Chromatin Immunoprecipitation.‑ Luciferase Assay to Study the Activity of a Cloned Promoter DNA Fragment.‑ Promoter Deletion Analysis using a Dual‑luciferase Reporter System.‑ Appli‑cation of mRNA Display for in vitro Selection of DNA‑binding Transcription Factor Complexes.‑ Isolation of Intracellular Protein:DNA Complexes using HaloCHIP; An Antibody Free Alternative to Chromatin Immunoprecipitation.‑ A Modi‑fied Yeast One‑Hybrid System for Genome Wide Identification of Transcription Factor Bind‑ing Sites.‑ Identifying Specific Protein‑‑DNA Interactions using SILAC‑‑based Quantitative Proteomics.‑ Electrophoretic Mobility‑Shift and Super‑Shift Assays for Studies and Characteriza‑tion of Protein‑DNA Complexes.‑ Combination of Native and Denaturing PAGE for the Detection of Protein Binding Regions in Long Fragments of Genomic DNA.‑ Quantitative NanoProteomics Approach for Protein Complex (QNanoPX) using Gold Nanoparticle‑based DNA Probe.‑ Chromatin Assembly and In Vitro Transcription Analyses for Evaluation of Individual Protein Activities in Mul‑ticomponent Transcriptional Complexes.‑ Using FRET to Monitor Protein‑induced DNA Bending: The TBP‑TATA Complex as a Model System. [...]

Fields of interestHuman Genetics; Gene Expression



Due January 2013

2013. X, 420 p. 79 illus., 31 in color. (Methods in Molecular Biology, Volume 977) Hardcover7 $139.00ISBN 978-1-62703-283-4

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P. Busson, Université Paris, Villejuif, France (Ed)

Nasopharyngeal CarcinomaKeys for Translational Medicine and Biology

This volume intends to contribute to “transla‑tional medicine and biology”. By this, we mean a bi‑directional process whose aim is to develop knowledge from basic science towards diagnostic and therapeutic applications and reciprocally to raise new questions for basic scientists.

Features 7 Presents current knowledge on viral and cellu‑lar oncogenesis and various aspects of host‑tumor interactions 7 Dedicated to therapeutics: NPC radiotherapy in terms accessible for the laymen, medical or systemic treatments of NPC and NPC immunotherapy 7 With numerous figures and tables

Contents Diagnosis and Clinical Evaluation of Nasophary Ngeal Carcinoma.‑ Histopathological Diagnosis of Nasopharyngeal Carcinoma: Looking beyond the Blue Book.‑ Descriptive, Environmental and Genetic Epidemiology of Nasopharyngeal Car‑cinoma.‑ Acquired Genetic and Epigenetic Alter Ations in Nasophary Ngeal Carcinoma.‑ Cellular Interactions in Nasopharyngeal Carcinomas.‑ Biological Tools for NPC Population Screening and Disease Monitoring.‑ Medical Imaging of Nasopharyngeal Carcinomas: Current Tools and Applications.‑ Radiotherapy of NPC: Current Strategies and Perspectives.‑ The Evolving Role of Systemic Therapy in Nasopharyngeal Carcinoma: Current Strategies and Perspectives.‑ Nasopharyn‑geal Carcinoma Immunotherapy: Current Strate‑gies and Perspectives.‑ Therapeutic Induction of Apoptosis in Nasophary Ngeal Carcinoma.

Fields of interestBiomedicine general; Cancer Research



Due March 2013

2013. XX, 204 p. 42 illus., 16 in color. (Advances in Experimental Medicine and Biology, Volume 778) Hardcover7 approx. $189.00ISBN 978-1-4614-5946-0

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17

T. J. Cleophas, European College Pharmaceutical Medicine, Lyon, France; A. H. Zwinderman, European Interuniversity, Lyon, France

Machine Learning in MedicineFeatures 7 Electronic health records of modern health facilities, are increasingly complex and systematic assessment of these records is virtually impos‑sible without special computationally intensive methods 7 Clinicians and other health profes‑sionals are not familiar with these methods, and this book is the first publication that systemati‑cally reviews such methods, particularly, for this audience 7 The book is written as a hand‑hold presentation also accessible to non‑mathemati‑cians, and as a must‑read publication for those new to the methods 7 The book includes step by step data analyses in SPSS, and can, therefore, also be used as a cookbook‑like guide for those starting with the novel methodologies

Contents Preface.‑ 1 Introduction to machine learning.‑ 2 Logistic regression for health profiling.‑ 3 Opti‑mal scaling: discretization.‑ 4 Optimal scaling: regularization including ridge, lasso, and elastic net regression.‑ 5 Partial correlations.‑ 6 Mixed linear modelling.‑ 7 Binary partitioning.‑ 8 Item response modelling.‑ 9 Time‑dependent predic‑tor modelling.‑ 10 Seasonality assessments.‑ 11 Non‑linear modelling.‑ 12 Artificial intelligence, multilayer Perceptron modelling.‑ 13 Artificial intelligence, radial basis function modelling.‑ 14 Factor analysis.‑ 15 Hierarchical cluster analysis for unsupervised data.‑ 16 Partial least squares.‑ 17 Discriminant analysis for Supervised data.‑ 18 Canonical regression.‑ 19 Fuzzy modelling.‑ 20 Conclusions. Index.

Fields of interestBiomedicine general; Entomology; Medicine/Pub‑lic Health, general

Target groupsPopular/general


Due January 2013

2013. X, 229 p. 44 illus., 19 in color. Hardcover7 $89.95ISBN 978-94-007-5823-0

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D. Corbeil, Dresden University of Technology, Germany (Ed)

Prominin‑1 (CD133): New Insights on Stem & Cancer Stem Cell BiologyContents Preface.‑ Prominin‑1 (CD133): Molecular and Cellular Features Across Species.‑ Prominin‑2 and Other Relatives of CD133.‑ Prominin‑1–con‑taining Membrane Vesicles: Origins, Formation and Utility.‑ Prominent Role of Prominin in the Retina.‑ Gene Regulation of Prominin‑1 (CD133) in Normal and Cancerous Tissues.‑ Prominin‑1 (CD133) and the Cell Biology of Neural Pro‑genitors and Their Progeny.‑ CD133–Positive Hematopoietic Stem Cells: From Biology to Medicine.‑ New Insights into the Renal Progenitor Cells and Kidney Diseases by Studying CD133.‑ CD133 Expression Strongly Correlates with the Phenotype of Very Small Embryonic/Epiblast‑like Stem Cells.‑ New Insights into the CD133 (Prom‑inin‑1) Expression in Mouse and Human Colon Cancer Cells.‑ Prominin‑1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells.‑ Prominin‑1 (CD133) Reveals New Faces of Pancreatic Progenitor Cells and Cancer Stem Cells: Current Knowledge and Therapeutic Perspectives.‑ Prominin‑1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives.‑ CD133‑Positive Cells for Cardiac Stem Cell Therapy: Current Sta‑tus and Outlook.‑ CD133+ Cells for the Treatment of Degenerative Diseases: Update and Perspec‑tives.‑ Index

Fields of interestCancer Research; Stem Cells; Medical Microbiol‑ogy



Due November 2012

2013. XVI, 262 p. 29 illus., 28 in color. (Advances in Experimental Medicine and Biology, Volume 777) Hardcover7 $189.00ISBN 978-1-4614-5893-7

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A. Dey, Anna University, Chennai, India (Ed)

Cytochrome P4502E1: Its Role in Disease and Drug MetabolismThe book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is criti‑cal for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress.

Features 7 Research overview 7 State of the art literature 7 Contributions by experts in the field 7 Deals extensively with mechanisms for injury

Contents Cytochrome P450 2E1 and its clinical aspects.‑ Nrf2 and antioxidant defense against CYP2E1 toxicity.‑ The role of Cytochrome P‑4502E1 in ethanol‑mediated carcinogenesis.‑ The Impor‑tance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome.‑ Relevance of CYP2E1 to non‑alcoholic fatty liver disease.‑ CYP2E1‑catalyzed alcohol metabolism.‑ CYP2E1, oxidative stress, post‑translational modifications and lipid metab‑olism.‑ The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system.

Fields of interestPharmacology/Toxicology; Life Sciences, general; Biochemistry, general



Due February 2013

2013. X, 290 p. 35 illus., 5 in color. Hardcover7 approx. $189.00ISBN 978-94-007-5880-3

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18

M. Hayat, Kean University, NJ, USA (Ed)

Tumors of the Central Nervous System, Volume 10Pineal, Pituitary, and Spinal Tumors

Contents Preface. I. Pineal tumors.‑ Papillary tumor of the pineal region.‑ Pineal region tumors: clinical aspects.‑ Papillary tumor of the pineal region: diagnosis.‑ Pineal parenchymal tumors: immu‑nohhistochemistry.‑ Pineal parenchymal tumors: diagnostics and prognosis.‑ Papillary tumors of the pineal region: diagnosis and treatment.‑ Pineal region tumors: optimal neurosurgical treatment.II. Pituitary tumors.‑ Pituitary tumors: genetics and heritable predisposition.‑ Xanthogranulomas associated with pituitary adenomas: magnetic resonance imaging.‑ Pituitary adenoma and cra‑niopharyngioma: an overview.‑ Familial pituitary adenomas: an overview.‑ Papillary glioneuronal tumor.‑ Solitary fibrous tumor.‑ Pituitary adeno‑mas: mcm2 protein as a cell proliferation marker.‑ Pituitary adenomas: role of cyclin‑dependent kinase inhibitors.‑ Pituitary tumorigenesis: role of regulation of wee1 kinase by micrornas.‑ Pituitary tumor cells: role of pkcα, pkcδ, and pckɛ expres‑sion.‑ Pituitary adenoma: role of hmga proteins.‑ Pituitary adenomas: role of e‑cadherin in tumor invasion.‑ Pituitary tumorigenesis: role of the wnt signaling pathway.‑ The role of aryl hydrocarbon receptor (ahr) and ahr‑interacting Protein (aip) in the pathogenesis of pituitary adenomas.‑ Pituitary tumors: role of pituitary tumor‑ transforming gene‑1 (pttg1).‑ Pituitary adenomas: endoscopic endonasal transphenoidal Technique.‑ Pituitary adenoma patients: hypofractionated cyberknife Radiosurgery (method).‑ Transspheniodal/tran‑scranial surgery of pituitary adenomas: Prognosis‑related occurrence for the trigemino‑cardiac reflex. III. Spinal tumors. [...]

Fields of interestCancer Research; Biomedicine general; Oncology

Target groupsGraduate


Due December 2012

2013. XXXIII, 448 p. 67 illus., 48 in color. (Tumors of the Central Nervous System, Volume 10) Hardcover7 $239.00ISBN 978-94-007-5680-9

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B. Henderson, UCL-Eastman Dental Institute, London, UK; A. G. Pockley, University of Sheffield, UK (Eds)

Cellular Trafficking of Cell Stress Proteins in Health and DiseaseContents Preface.‑ Contents.‑ Note on Nomenclature.‑ Au‑thor Addresses.‑ Section 1 Historical Introduc‑tion to Secreted Cell Stress Proteins as Signalling Proteins.‑ Discovery of the Cellular Secretion of Cell Stress Proteins.‑ Discovery of the Agonist Activities of Molecular Chaperones and Protein‑Folding Catalysts.‑ Identification of Cell Stress Proteins in Biological Fluids.‑ Section 2 Intra‑cellular Trafficking of Molecular Chaperones and its Consequences.‑ Hsp27 Phosphorylation Patterns and Cellular Consequences.‑ Evidence on Cholesterol‑Controlled Lipid Raft Interaction of the Small Heat Shock Protein HSPB11.‑ Hsp70 Chaperone Systems in Vesicular Trafficking.‑ Pathways of Hsp70 Release: Lessons from Cyto‑kine Secretion.‑ Nucleolin: A Novel Intracellular Transporter of HSPA1A.‑ The Hsp90‑Based Protein Trafficking System and Linkage to Protein Quality Control.‑ Section 3 Molecular Chaperones as Cell Surface Receptors and Receptor Ligands.‑ Cell Surface Molecular Chaperones and the LPS Receptor.‑ Hsp60: An Unexpected Cell Surface Receptor in Prokaryotes and Eukaryotes.‑ Patho‑physiological Barriers Impeding the Delivery of Heat Shock Protein (HSP)‑based Macromolecules and Nanotherapeutics to Solid Tumors.‑ The Chaperokine Activity of HSPA1A.‑ Molecular Chaperones and Scavenger Receptors: Binding and Trafficking of Molecular Chaperones by Class F and Class H Scavenger Receptors.‑ Grp78 (BiP): A Multifunctional Cell Surface Receptor.‑ Section 4 Extracellular Secretion of Molecular Chaperones in Prokaryotes and Eukaryotes. [...]

Fields of interestHuman Physiology; Life Sciences, general; Neu‑rosciences



Due November 2012

2012. I, 399 p. (Heat Shock Proteins, Volume 6) Hardcover7 $209.00ISBN 978-94-007-4739-5

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P. S. Hiemstra, Leiden University Medical Center, The Netherlands; S. A. Zaat, Academic Medical Center, Amsterdam, The Netherlands (Eds)

Antimicrobial Peptides and Innate ImmunityAntimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense sys‑tem in bacteria, plants, animals and humans.

Features 7 Provides a comprehensive overview on these endogenous antibiotics 7 Includes information on role in inflammatory diseases and gives an out‑look on new therapeutic options 7 Written by experts in the field of antimicrobial/host defense peptide research

Contents Evolution of Antimicrobial Peptides: a View From the Cystine Chapel.‑ Innate immunity in plants: the role of antimicrobial peptides.‑ Antimicrobial peptides produced by microorganisms.‑ LL‑37: an immunomodulatory antimicrobial host defence peptide.‑ Wound Repair and Antimicrobial Pep‑tides.‑ WAPing out pathogens and disease in the mucosa‑roles for SLPI and trappin‑2.‑ Histatins: multifunctional salivary antimicrobial peptides.‑ Structure‑function relationships of antimicrobial chemokines.‑ Mechanisms and Significance of Bacterial Resistance to Human Cationic Anti‑microbial Peptides.‑ Antimicrobial peptides and inflammatory bowel disease.‑ Cystic Fibrosis and Defective Airway Innate Immunity.‑ Antimicro‑bial peptides in chronic obstructive pulmonary disease.‑ Host defense peptides: Immune modula‑tion and antimicrobial activity in vivo.‑ Helping the host – induction of antimicrobial peptides as a novel therapeutic strategy against infections.

Fields of interestImmunology; Infectious Diseases; Biochemistry, general



Due December 2012

2013. XIV, 362 p. 37 illus., 15 in color. (Progress in Inflammation Research) Hardcover7 $199.00ISBN 978-3-0348-0540-7

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19

K. K. Jain, Jain PharmaBiotech, Basel, Switzerland

Applications of Biotechnology in NeurologyCulling together excerpts from a wide range of writings by Dr. Kewal K. Jain on biotechnology topics as they relate to disorders of the nervous system, Applications of Biotechnology in Neurol‑ogy covers a variety of applications for those working in life sciences and the pharmaceutical sciences, particularly those developing diagnostics and therapeutics for the nervous system.

Features 7 Gathers a wide variety of biotechnologi‑cal topics related to disorders of the nervous system 7 Features detailed chapters highlighting current approaches and techniques 7 Includes many selected references from recent relevant lit‑erature as well as a multitude of tables and figures

Contents Introduction to Neurobiotechnology.‑ Neuroge‑netics & Neurogenomics.‑ Neuroproteomics.‑ Biomarkers of Neurological Disorders.‑ Molecular Diagnostics for Neurological Disorders.‑ Mo‑lecular Neuropharmacology.‑ Ion Channels and Neurology.‑ Role of Nitric Oxide in Neurological Disorders.‑ Nanoneurology.‑ Neurotrophic Fac‑tors.‑ Cell Therapy of Neurological Disorders.‑ Gene Therapy of Neurological Disorders.‑ Role of Biotechnology in Drug Delivery to the Nervous System.‑ Vaccines for Neurological Disorders.‑ Biotechnology for Neuroprotection.‑ Biotechnol‑ogy in Neuroregeneration.‑ Role of Biotechnology in Neurosurgery.‑ Personalized Neurology.

Field of interestNeurosciences



Due December 2012

2013. XXV, 460 p. 16 illus., 5 in color. Hardcover7 $159.00ISBN 978-1-62703-271-1

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JIMD ReportsE. Morava, G. Brown (Eds), Managing editor: V. Peters, Editor-in-chief: J. Zschocke, K. M. Gibson

Volume 8

J. Zschocke, Medical University Innsbruck, Austria; K. M. Gibson, Michigan Technological University, Houghton, MI, USA; G. Brown, University of Oxford, UK; E. Morava, Radboud University Nijmegen, The Netherlands; V. Peters, Heidelberg University Hospital, Germany (Eds)

JIMD Reports ‑ Case and Research Reports, 2012/5JIMD Reports publishes case and short re‑search reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.

Features 7 Unique collection of case and research reports on rare metabolic disorders 7 Contains unusual or previously unrecorded features relevant to metabolic disorders 7 All contributions rigor‑ously peer‑reviewed

Contents Different case studies.

Fields of interestHuman Genetics; Metabolic Diseases; Pediatrics



Available

2013. VII, 152 p. 40 illus., 21 in color. Softcover7 $139.00ISBN 978-3-642-33432-0

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L. Kaestner, Universität des Saarlandes, Saarbrücken, Germany

Calcium signallingApproaches and Findings in the Heart and Blood

The book combines general concepts and methods to investigate calcium signalling in cells ranging from molecular biology approaches to manipula‑tion of calcium in living cells. The focus within these methods in on the broad range of fluores‑cence imaging technology, in particular on optical sectioning techniques and fast image acquisition. In addition to these general guidelines there are application examples in a context beyond calcium signalling in two major fields: investigations of isolated cardiac myocytes and red blood cell related research. While the cellular cardiology section provides snapshots of certain calcium signalling aspects, the red blood cell part presents an overview from the functional identification of calcium‑channels to a concept of physiological and pathophysiological relevance.

Features 7 Broad topical coverage from general con‑cepts to detailed examples 7 96 Figures and 4 Tables 7 Includes latest developments and research results

Contents Summary.‑ Calcium Signalling Methodology.‑ Calcium Signalling in Cardiac Myocytes.‑ Calcium Signalling in Red Blood Cells.‑ Index.

Fields of interestBiomedicine general; Biological Microscopy; Cardiology



Due October 2012

2013. Approx. 260 p. 96 illus. Softcover7 $89.95ISBN 978-3-642-34616-3

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20

J. W. Laan, National Institute, Bilthoven, The Netherlands; J. J. DeGeorge, Merck Research Laboratories, West Point, PA , USA (Eds)

Global Approach in Safety TestingICH Guidelines Explained

Contents The International Conference on Harmonisation. History of Safety Guidelines.‑ EU Perspective on ICH.‑ The Value and Benefits of the International Conference on Harmonisation (ICH) to Drug Regulatory Authorities Advancing Harmonization for Better Public Health.‑ A Japanese Perspective on Implementation of the Three Rs: Incorporating Best Scientific Practices into Regulatory Process.‑ Towards more Scientific Relevance in Carcinoge‑nicity Testing.‑ The Evolution, Scientific Reason‑ing and Use of ICH S2 Guidelines for Genotoxicity Testing of Pharmaceuticals.‑ Toxicokinetics: A Guidance for Assessing Systemic Exposure in Toxicology Studies , Where are we now; an S3A/S3B update (1995‑2011).‑ Duration of Acute and Chronic Toxicity Testing in Animals (ICH S4A and S4B).‑ Why and how did Reproduction Toxicity Testing make its early entry into and Rapid Success in ICH?.‑ ICH S6 Preclinical Safety Evaluation of Biotechnology‑Derived Pharmaceu‑ticals.‑ Safety Pharmacology: Guidelines S7A and S7B.‑ ICH S8: History and Perspectives.‑ ICH S9: Nonclinical Evaluation of Anticancer Pharmaceu‑ticals a Perspective from Regulators on the De‑velopment of the Guideline.‑ Non‑Clinical Safety Studies for the Conduct of Human Clinical Trials for Pharmaceuticals ICH M3 and M3(R2).

Fields of interestPharmaceutical Sciences/Technology; Biomedi‑cine general



Due February 2013

2013. XII, 317 p. 12 illus., 10 in color. (AAPS Advances in the Pharmaceutical Sciences Series, Volume 5) Hardcover7 $189.00ISBN 978-1-4614-5949-1

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S. Lentzsch, Columbia University, New York, NY, USA (Ed)

Genetic and Molecular Epidemiology of Multiple MyelomaMultiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytoge‑netic abnormalities that accounts for 1.4% of all cancers, and approximately 10% of hematologic malignancies. The clinical manifestations of multi‑ple myeloma include lytic bone lesions, cytopenia, hypercalcemia, renal dysfunction, hyperviscosity of the blood, immunodeficiency, and peripheral neuropathy. Based on the clinical and genetic data, probably all cases of multiple myeloma arise from an asymptomatic monoclonal gammopathy of un‑known significance. The exact mechanism of the transition from MGUS to overt multiple myeloma is still not well understood.

Features 7 Explores the role of protein translation in multiple myeloma 7 Discusses epigenetic gene silencing as a new target for multiple myeloma immune surveillance 7 Examines the cell cycle control of plasma cell differentiation

Contents Preface.‑ Genetics of Multiple Myeloma.‑ Gene expression signature in MGUS and multiple my‑eloma.‑ Cap‑Dependent Protein Translation Ini‑tiation in Multiple Myeloma: an Attractive Target for Therapy.‑ IRES‑dependent, CAP‑independent translation in Multiple Myeloma.‑ Epigenetic gene silencing as a new target for multiple myeloma.‑ Role of Bone Disease in the Pathogenesis of Multiple Myeloma.‑ Index.

Fields of interestCancer Research; Cell Biology; Human Genetics



Due December 2012

2013. XXVIII, 170 p. 15 illus., 13 in color. Hardcover7 $189.00ISBN 978-1-4614-4659-0

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D. Leszczynski, Governmental Research Institution, Helsinki, Finland (Ed)

Radiation ProteomicsThe effects of ionizing and non-ionizing radiation on cells and tissues

Methods of proteomics have been shown to be powerful tools in search of target proteins – proteins that respond in cells to an internal or an external stimulus. Proteomics is widely used in biomedical research.

Features 7 Up to date review of proteomics studies exam‑ining radiation effects on cells and tissues 7 In‑cluded both ionizing and non‑ionizing radiation effects 7 Review of low‑dose ionizing radiation effects 7 Review of therapeutic doses of ion‑izing radiation effects and search for biomarkers of response/damage 7 Non‑ionizing radiation chapters deal with ELF‑EMF, RF‑EMF and UV

Contents Mass spectrometry‑based proteomics: Basic prin‑ciples and emerging technologies and directions.‑ Ionizing radiation effects on cells, organelles and tissues on proteome level.‑ Radiation treatment effects on the proteome of the tumour microenvi‑ronment.‑ Serum and plasma proteomics and its possible use as detector and predictor of radiation diseases.‑ The Urine Proteome as a Radiation Biodosimeter.‑ Effects of radiofrequency‑modu‑lated electromagnetic fields on proteome.‑ Global protein expression in response to extremely low frequency magnetic fields.‑ Ultraviolet radiation effects on the proteome of skin cells.‑ Effects of ultraviolet radiation on skin cell proteome.

Fields of interestBiomedicine general; Proteomics; Effects of Radia‑tion/Radiation Protection



Due February 2013

2013. X, 130 p. 24 illus., 10 in color. (Advances in Experimental Medicine and Biology, Volume 990) Hardcover7 approx. $139.00ISBN 978-94-007-5895-7

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21

S. Mandel, Eve Topf Center, Haifa, Israel (Ed)

Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the FutureContents 1. What is this book series about?‑ 2. Preface.‑ 3. Introductory chapter.‑ 4. Individual predisposi‑tions in healthy vasospastic individuals: Patient profiling for targeted prevention of “down‑stream” pathologies as cost‑effective personalised medi‑cine.‑ 5. Idiopathic REM sleep behavior disorder as a long‑term predictor of neurodegenerative disorders.‑ 6. New animal models of progressive neurodegeneration: tools for developing predictive diagnostics and identifying presymptomatic thera‑peutic targets.‑ 7. Tau pathology: A selected view on the current status.‑ 8. The Use of Biomarkers for Prediction and Prevention of Alzheimer’s and Parkinson’s Diseases.‑ 9. Making clinical trials of Alzheimer’s disease delay‑of‑onset a reality by use of a prognostic genetic biomarker.‑ 10. An update on CSF biomarkers of Parkinson’s disease.‑ 11. Glaucomatous optic neuropathy: Risk assess‑ment and potential targets for effective prevention and treatments tailored to the patient.‑ 12. Toward a personalized approach in amyotrophic lateral sclerosis: new developments in diagnosis, genetics, pathogenesis and therapies.‑ 13. Recent advances in ALS research: perspectives for personalized clinical application.‑ 14. Exercise in Multiple Scle‑rosis – an Integral Component of Disease Manage‑ment.‑ 15. Bridging the Informatics Gap between Bench and Bedside: Implications to Neurodegen‑erative Diseases.‑ 16. Personalized Medicine In Rare Paediatric Neurometabolic Diseases.

Fields of interestBiomedicine general; Health Promotion and Dis‑ease Prevention; Neurology



Due February 2013

2013. XXX, 260 p. 140 illus., 60 in color. (Advances in Predictive, Preventive and Personalised Medicine, Volume 2) Hardcover7 $189.00ISBN 978-94-007-5865-0

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N. C. Munshi, K. C. Anderson, Dana Farber Cancer Institute, Boston, MA USA (Eds)

Advances in Biology and Therapy of Multiple MyelomaContents Volume 1.‑ Genomic strategies determining progressions from MGUS to Multiple Myelo‑ma.‑ Prognostic implication of Genetic changes (Cytogenetics, and FISH, gains and losses of DNA by SNP array and aCGH) in risk stratification in myeloma.‑ Advances in MM gene expression profiling.‑ Growth factors in MM.‑ Role of Wnt signaling pathways in multiple myeloma patho‑genesis.‑ mTOR pathway in multiple myeloma.‑ Jak/STAT signaling in the pathogenesis and treat‑ment of multiple myeloma.‑ Role of extracellular matrix in myeloma biology.‑ Osteoclasts: Potential target for blocking microenvironmental support of myeloma.‑ Targeting the BAFF/APRIL cytokine network in multiple myeloma.‑ Role of Osteoblast in myeloma pathology.‑ Migration and homing in Multiple Myeloma.‑ Genes and proteins of myeloma endothelial cells to search specific targets of the tumor vasculature.‑ Epigenetic regulation of myeloma within its bone marrow microenviron‑ment.‑ Targeting mulitple myeloma tumor angio‑genesis: focus on VEGF.‑ Novel in vivo model in myeloma.‑ Index.‑ Volume 2.‑ T cell responses in myeloma.‑ Novel antigenic targets for immuno‑therapy in myeloma.‑ Antibody‑based therapies in Multiple Myeloma.‑ Defining multiple myeloma as a target for DNA gene fusion vaccines.‑ Har‑nessing allogeneic immunity for anti‑myeloma response.‑ Dendritic cell and peptide‑based vacci‑nation in myeloma.‑ New Proteasome inhibitors.‑ Newer Imids.‑ New agents in myeloma.‑ Early Combination Studies in MM.‑ The effect of novel antimyeloma agents on bone metabolism.‑ Index.

Fields of interestCancer Research; Pharmacology/Toxicology



Due November 2012

2013. XX, 530 p. (2-volume-set)7 approx. $303.00ISBN 978-1-4614-6091-6

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V. Quesniaux, B. Ryffel, Orleans University and CNRS, Orleans, France; F. Padova, Novartis Institutes for Biomedical Research, Basel, Switzerland (Eds)

IL‑17, IL‑22 and Their Producing Cells: Role in Inflammation and AutoimmunityContents IL‑17A family, receptors, proinflammatory effects and production.‑ IL‑22 and IL‑17 overview.‑ IL‑17R family: Structure, signal transduction and function.‑ Contribution of IL‑22 to Th17 responses: repairing and protecting peripheral tissues.‑ Central role of Th‑17 cells in adaptive im‑mune responses.‑ Regulatory T cells vs Th17: Dif‑ferentiation of Th17 versus Treg are they mutually exclusive Other sources of IL‑17: iNKT cells.‑ Ret‑inoic acid in mucosal immune regulation.‑ Critical role of IL‑17 in experimental arthritis.‑ Dual role IL‑17A, F and IL‑22 in allergic asthma.‑ Inflam‑masome ‑ IL‑1 ‑ IL‑17 response in lung inflamma‑tion.‑ The role of Il‑17 in exp autoimmune myco‑carditis.‑ Th17 cells in transplantation: actors or innocent bystanders.‑ Is IL‑17 required to control of tuberculosis IL‑17 and mucosal host defense. Role of IL‑17 and IL‑17 family cytokines on tumor development.‑ IL‑17 and TH17 cells in rheuma‑toid arthritis and other inflammatory conditions.‑ Targeting Th17 Cells for therapy of multiple sclerosis.‑ Involvement of interleukin‑17 cytokines in human asthma.‑ IL‑17 and/or IL‑22 as potential target(s) for Crohn’s disease.‑ Role of IL‑23, IL‑17 and IL‑22 in psoriasis.‑ Contribution of IL‑22 to experimental skin inflammation.‑ Genetic mouse models to investigate IL‑17 responses.‑ IL‑17A as a therapeutic target for autoimmune diseases.

Fields of interestImmunology; Cytokines and Growth Factors; Receptors



Due December 2012

2nd revised edition

2nd ed. 2013. X, 358 p. 25 illus., 14 in color. (Progress in Inflammation Research) Hardcover7 $259.00ISBN 978-3-0348-0521-6

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22

J. A. Radosevich, University of Illinois, Chicago, Il, USA (Ed)

Head & Neck Cancer: Current Perspectives, Advances, and ChallengesContents 1 Overview of “Head and Neck Cancer: Cur‑rent Perspectives, Advances, and Challenges”.‑ 2 A Disease Without History? Evidence For The Antiquity of Head and Neck Cancers.‑ 3 Head and Neck Cancer Epidemiology and Health Services Research.‑ 4 Challenges in Community‑Based Head and Neck Cancer Prevention Programs.‑ 5 Head and Neck Anatomy.‑ 6 Screening and Patient Examination.‑ 7 Benign Neoplasms of the Head and Neck.‑ 8 Benign Non‑Neoplastic Lesions of the Head and Neck.‑ 9 Pathology of Head and Neck Cancer I: Epithelial and Related Tumors.‑ 10 Pathology of Head and Neck Cancer II: Mesenchy‑mal and Lymphoid Tumors.‑ 11 Cytopathology of Head and Neck Lesions.‑ 12 Squamous Cell Carci‑noma of the Head and Neck and Cervix: Overlap and Distinctions.‑ 13 Viruses and Head and Neck Cancer.‑ 14 Head and Neck Carcinogenesis: A Product of Complex Evolutionary Forces.‑ 15 Nu‑trition and Head and Neck Cancer.‑ 16 Treatment Planning Considerations.‑ 17 Medical Oncol‑ogy: Planning Considerations and Practices.‑ 18 Role of Surgery in Treatment of Head and Neck Cancer.‑ 19 Diagnostic Imaging Considerations.‑ 20 Radiotherapy of Head and Neck Cancers.‑ 21 Laser Treatment for Head and Neck Cancer.‑ 22 Photodynamic Therapy (PDT): An Evolving Therapeutic Technique in Head and Neck Cancer Treatment.‑ 23 The Changing Face of Maxillofacial Prosthodontics.‑ 24 Complications from Surgical Treatment of Oral Cancer.‑ 25 Psychological issues in Head and Neck Cancer.‑ 26 Quality of Life Is‑sues in Research and Clinical Practice. [...]

Fields of interestCancer Research; Oncology; Otorhinolaryngology



Due February 2013


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M. S. Ritsner, Technion - Israel Institute of Technology, Haifa, Israel (Ed)

Polypharmacy in Psychiatry Practice, Volume IMultiple Medication Use Strategies

Features 7 This is the first comprehensive volume regard‑ing the multiple medication use in psychia‑try 7 Preclinical and clinical investigation of the multiple medication use in psychiatry 7 Evi‑dence‑based monitoring important research developments in this field

Contents 1. Multiple medication use in psychiatry: How Ra‑tional Can It Be?. ‑ 2. Receptor binding targets for antipsychotic efficacy. ‑ 3. Drug interactions and polypharmacy. ‑ 4. Preclinical and clinical investi‑gation of antipsychotic polypharmacy: What is the evidence?. ‑ 5. Should high dose or very long‑term antipsychotic monotherapy be considered before antipsychotic polypharmacy?. ‑ 6. Multiple Medication Use of Neuropsychiatry in Forensic Psychiatry: Findings from the Central State Fo‑rensic Psychiatric Hospital of Saxony‑Anhalt. ‑ 7. Antipsychotic treatment within a naturalistic trial ‑ how are we treating schizophrenia patients in the “real‑world”?. ‑ 8. A multi‑target drug treatment in schizophrenia using adjunctive agents with non‑D2 mechanisms of action. ‑ 9. Antidepres‑sants in schizophrenia – a place for them?. ‑ 10. Stressful life events and anticonvulsant medication in psychiatric patients. ‑ 11. Multiple medication use in somatic symptom disorders: from augmen‑tation to diminution strategies.

Fields of interestBiomedicine general; Psychiatry; Pharmacy



Due January 2013


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M. S. Ritsner, Technion - Israel Institute of Technology, Haifa, Israel (Ed)

Polypharmacy in Psychiatry Practice, Volume IIUse of Polypharmacy in “Real World”

Features 7 This is the first comprehensive volume regard‑ing the multiple medication use in psychia‑try 7 Preclinical and clinical investigation of the multiple medication use in psychiatry 7 Evi‑dence‑based monitoring important research developments in this field

Contents 1. Antipsychotic polypharmacy for schizophrenia: ‘Secret sauce’ or ‘wild abandon’?.‑ Antipsychotic polypharmacy in USA.‑ Antipsychotic polyphar‑macy in Czech Republic and in Ukraine.‑ Anti‑psychotic polypharmacy in residential facilities in Italy: the gap between recommendations and real world practice.‑ Antipsychotic polyphar‑macy and associated phenomena in patients with schizophrenia: Rational or irrational?.‑ Antipsy‑chotic polypharmacy in schizophrenia. How to counteract this common practice?.‑ Clozapine combinations in treatment‑resistant schizophrenia patients.‑ Metabolic syndrome and antipsychotic polypharmacy.‑ Evidence based combination therapy for bipolar disorder.‑ Antidepressant combination strategies for major depressive disorder.‑ Herbal remedies and nutraceuticals as augmentation or adjunct for mood and anxiety disorders: evidence for benefit and risk.‑ Obses‑sive‑compulsive syndromes in schizophrenia: A case for polypharmacy?.‑ Polypharmacy and potentially inappropriate medication use among elders with dementia.‑ The role of polypharmacy in bipolar disorder treatment guidelines.

Fields of interestBiomedicine general; Psychiatry; Pharmacy



Due January 2013

2013. XIV, 282 p. 1 illus. Hardcover7 $209.00ISBN 978-94-007-5798-1

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23

I. Roterman-Konieczna, Department of Bioinformatics and Telemedicine, Jagiellonian University, Medical College, Cracow, Poland (Ed)

Identification of Ligand Binding Site and Protein‑Protein Interaction AreaFeatures 7 Comparative analysis of models based on geometry versus those based on knowledge of the biological phenomenon Application note Relation to biological phenomena 7 All illustrations in full color 7 A review of the latest numerical techniques used to identify ligand binding and protein complexation sites

Contents Contributors.‑ Foreword.‑ Chapter 1 SuMo, J‑A. Chemelle, E. Bettler, CH. Combet, R. Terreux, CH. Geourjon, G. Deleage.‑ Chapter 2 Identification of pockets on protein surface to predict protein–ligand binding sites, Binding Huang.‑ Chapter 3 Can the structure of the hydrophobic core determine the complexation site?, M. Banach, L. Konieczny, I. Roterman.‑ Chapter 4 Comparative analysis of techniques oriented on the recognition of ligand binding area in proteins, P. Alejster, M. Banach, W. Jurkowski, D. Marchewka, I. Roter‑man.‑ Chapter 5 Docking predictions of protein‑protein interactions and their assessment, Joel Janin.‑ Chapter 6 Prediction of protein‑protein binding interfaces, D. Marchewka, W. Jurkowski, M. Banach, I. Roterman.‑ Chapter 7 Support for Cooperative Experiments in e‑Science: From Scientific Workflows to Knowledge Sharing, A. Belloum, R. Cushing, S. Koulouzis, V. Korkhov, D. Vasunin, V. Guevara‑Masis, Z. Zhao, M. Bubak.‑ Index.

Field of interestBiomedicine general



Due November 2012

2013. X, 167 p. 58 illus., 47 in color. (Focus on Structural Biology, Volume 8) Hardcover7 $189.00ISBN 978-94-007-5284-9

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New SeriesSpringerBriefs in Biochemistry and Molecular BiologySpringerBriefs in Biochemistry and Molecular Bi‑ology are a series of slim high quality publications encompassing the entire spectrum of biochemistry and molecular biology. Each individual proposal will be evaluated by hand‑picked external review‑ers to ensure publication of Springer Briefs of the highest standard. SpringerBriefs published in the series represent the cutting edge in biochemistry and molecular biology research in a format inter‑secting the traditional review and the scientific book volume.

P. K. Sahu, Raghu College of Pharmacy,Tamil Nadu, India; M. Janarthan, Nimra College of Pharmacy, Gujarat, India; D. K. Sahoo, Avanthi Institute of Pharmaceuticals Sciences,Andhra Pradesh, India

Statin: A Chemopreventive Agent for Liver Carcinogenesis in RatStatin is a potential antihypercholesterolemic agent, which inhibits 3‑hydroxy‑3‑methylglutaryl coenzyme A (HMG‑CoA) reductase, the rate limiting enzyme of cholesterol biosynthesis. The beneficial effects of statin therapy, however, are not limited to patients with hypercholesterolemia. In‑creasing evidence suggest that an activity level of HMG‑CoA reductase may affect various cellular functions such as DNA synthesis, cell prolifera‑tion, diverse signal transduction pathways leading to pathogenesis. The use of HMG‑CoA reductase inhibitor in varying diseases is under investiga‑tion. This book is the most current hands‑on book in the field of hepatocarcinogenesis.

Features 7 The book deals with noble use of statin for prevention and treatment of cancer and thus provides a platform for the researchers in cancer therapy 7 The text is well supported by color photographs of hepatic histopathology (mor‑phometeric analysis) providing the evidence of cancer inhibitory effect of statin 7 The easy demonstration of the research methodology helps the researcher to learn quickly

Contents 1.Introduction.‑ 2.Materials and Methods.‑ 3.Re‑sults and Discussion.‑ 4.Summary and Conclu‑sions.‑ 5.Bibliography.

Fields of interestCancer Research; Protein‑Ligand Interactions; Enzymology



Due February 2013

2013. Approx. 110 p. 41 illus. in color. (SpringerBriefs in Biochemistry and Molecular Biology, Volume 1) Softcover7 approx. $69.95ISBN 978-81-322-0866-2

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24

J. Sebestik, Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic; M. Reinis, Institute of Molecular Genetics, Prague, Czech Republic; J. Jezek, Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic

Biomedical Applications of Peptide‑, Glyco‑ and Glycopeptide Dendrimers, and Analogous Dendrimeric StructuresContents Introduction.‑ Chemistry and struture to dendrimers: Definition of terms and nomen‑clature.‑ Sugar code (glyco code).‑ Classes of peptide‑, glyco, and glycopeptide dendrimers.‑ The dendritic state and dendritic effects.‑ Syn‑thesis of dendrimers: convergent and divergent approaches.‑ Purification and characterization of dendrimers.‑ Dendrimeric libraries.‑ Dendrimers in catalysis.‑Dendrimers and their biological and therapeutic applications: Dendrimers and solubil‑ity.‑ Biocompability and toxicity of dendrimers.‑ Dendrimers in nanoscience and nanotechnology.‑ Dendrimers in drug delivery.‑ Dendrimers in gene delivery.‑Dendrimers and bacteria.‑ Dendrimers and viruses.‑ Dendrimers and parasites.‑ Can‑cer.‑ Diagnostics, lectin detection and cell‑cell interactions.‑ Dendrimers as biosensors and imaging tools.‑ Dendrimers regulating in intracel‑lular signaling pathways.‑ Vaccines and immuno‑modulation.‑ Dendrimers in neurodegenerative diseases.‑ Conclusions and persperctives.

Fields of interestMolecular Medicine; Biomedicine general; Phar‑maceutical Sciences/Technology



Due December 2012


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A. L. Snow, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; M. J. Lenardo, National Institutes of Health, Bethesda, MD, USA (Eds)

Immune HomeostasisMethods and Protocols

Contents Quantitating Lymphocyte Programmed Cell Death (PCD) In Vitro Using Simple Kill Assays.‑ Fluoresence‑Activated Cell Sorting (FACS)‑Based Quantitation of T Cell Receptor Restimulation‑Induced Cell Death (RICD) in Activated, Primary Human T Cells.‑ Evaluation of IL‑2‑Withdrawal Induced Apoptosis in Human T Lymphocytes.‑ Determination of Apoptosis Sensitivity in Specific T Cell Subsets from Human Peripheral Blood by Utilizing a Multi‑Parameter Fluorescence Activated Cell Sorting (FACS)‑Based Technique.‑ Visualization of Fas‑Mediated Death‑Inducing Signaling Complex (DISC) Formation by Im‑munoprecipitation.‑ Analyses of Programmed Cell Death in Dendritic Cells.‑ Detection of Necrosis by Release of Lactate Dehydrogenase (LDH) Activity.‑ Assessment of CD4+ and CD8+ T Cell Responses Using MHC Class I & II Tetramers.‑ Homeostatic Proliferation of Mature T Cells.‑ Quantitating Lymphocyte Homeostasis In Vivo in Humans Using Stable Isotope Tracers.‑ Real‑Time Quantitative (RQ‑)PCR Approach to Quantify the Contribution of Proliferation to B Lymphocyte Homeostasis.‑ Molecular Measure‑ment of T Cell Receptor Excision Circles.‑ Isola‑tion of RNA and the Synthesis and Amplifica‑tion of cDNA from Antigen‑Specific T Cells for Genome‑Wide Expression Analysis.‑ Designs for Massively Parallel Sequencing Approaches to Identify Causal Mutations in Human Immune Disorders.‑ Flow Cytometric Measurement of SLAM‑Associated Protein (SAP) and X‑Linked Inhibitor of Apoptosis (XIAP). [...]

Field of interestImmunology



Due January 2013

2013. XX, 450 p. 32 illus., 11 in color. (Methods in Molecular Biology, Volume 979) Hardcover7 $119.00ISBN 978-1-62703-289-6

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G. Steinhoff, University of Rostock, Germany (Ed)

Regenerative MedicineFrom Protocol to Patient

Contents Foreword, Gustav Steinhoff et al..‑ 1 History of Regenerative Medicine, Raymund E. Horch et al..‑ Part I Biology of Tissue Regeneration.‑ 2 Extracellular Matrix and Tissue Regeneration, Yrjö T. Konttinen et al..‑ 3 Stem Cell Niche, Chen‑hui Wang et al..‑ 4 Stem Cells and Asymmetric Cell Division, Frank Hirth.‑ 5 Stem Cells in the Developing and Adult Nervous System, Fumitaka Osakada et al..‑ Part II Stem Cell Science and Technology.‑ 6 Characterization and Classifica‑tion of Stem Cells, Ute Bissels et al..‑ 7 Human Embryonic Stem Cells, Mikael C.O. Englund et al..‑ 8 Induced Pluripotent Stem Cells, Keisuke Okita et al..‑ 9 Spermatogonial Stem Cells, Ilya Chuykin et al..‑ 10 Hematopoietic Stem Cells, Mary Clarke et al..‑ 11 Cardiovascular Stem Cells, Christoph Brenner et al..‑ 12 Neural Stem Cells, Yoko Arai et al..‑ 13 Liver Stem Cells, Tohru Itoh et al..‑ 14 Gastrointestinal Stem Cells, M. Sasikala et al..‑ 15 Cancer Stem Cells, Murali MS Balla et al..‑ 16 Mesenchymal Stem Cells, Patrick Wuchter et al..‑ 17 Musculoskeletal Stem Cells, Gerben M. van Buul et al..‑ Part III Tissue Engineering, Biomaterials and Nanotechnology.‑ 18 When Stemness Meets Engineering, Maurizio Pesce et al..‑ 19 Vector Technology and Cell Targeting, Julia Bäder et al..‑ 20 Regenerative Chimerism Bioengineered through Stem Cell Reprogram‑ming, Timothy J. Nelson et al..‑ 21 Biodegradable Materials, Michael Schroeter et al..‑ 22 Biomate‑rials, Naresh Polisetti et al..‑ 23 Functionalized Nanomaterials, Jie Zhou et al..‑ 24 Biointerface Technology, Joachim Rychly.‑ Part IV Regenera‑tive Therapies.‑ 25 Emerging Concepts in Myocar‑dial Pharmacoregeneration, Laura C. Zelarayan et al..‑ 26 Blood, Michael Schmitt et al.. [...]

Fields of interestBiomedicine general; Stem Cells; Surgery

Target groupsGraduate


Due January 2013

2nd ed. 2013. XXXIII, 1037 p. 149 illus., 82 in color. Hardcover7 $279.00ISBN 978-94-007-5689-2

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25

G. H. Su, Columbia University Medical Center, New York, NY, USA (Ed)

Pancreatic CancerMethods and Protocols

Contents Identification and Analysis of Precursors to Invasive Pancreatic Cancer.‑ Tissue Microarrays: Construction and Use.‑ Immunohistochemistry of Pancreatic Neoplasia.‑ A Method for Conducting Highly Sensitive microRNA in situ Hybridization and Immunohistochemical Analysis in Pancreatic Cancer.‑ Optimal Molecular Profiling of Tissue and Tissue Components: Defining the Best Pro‑cessing and Microdissection Methods for Biomed‑ical Applications.‑ Considerations for Sequencing Analyses of Pancreatic Cancer Progression and Metastasis.‑ DNA Methylation Analysis in Human Cancer.‑ Quantitative Real‑Time PCR Expression Analysis of Peripheral Blood Mononuclear Cells in Pancreatic Cancer Patients.‑ Development of a Cy‑tokine‑modified Allogeneic Whole Cell Pancreatic Cancer Vaccine.‑ The Prevention and Genetics of Pancreatic Cancer – A Programmatic Approach.‑ Development of Orthotopic Pancreatic Tumor Mouse Models.‑ Evaluating Dietary Compounds in Pancreatic Cancer Modeling Systems.‑ Quan‑tification of Murine Pancreatic Tumors by High Resolution Ultrasound.‑ Microdissection and Cul‑ture of Murine Pancreatic Ductal Epithelial Cells.‑ Sphere‑forming Assays for Assessment of Benign and Malignant Pancreatic Stem Cells.‑ Analysis of Transplanted Bone Marrow Derived Cells in Chronic Pancreatitis.‑ Analysis of the Potential for Pancreatic Cancer Metastasis In Vitro and In Vivo.‑ The use of Fluorescent Probes in the Study of Reactive Oxygen Species in Pancreatic Cancer Cells.‑ Analysis of Tumor Associated Mucin Glycotopes by Western Transfer Methods.‑ Evalu‑ating Tumor Angiogenesis.‑ Pooled Genome‑wide RNAi Screenings. [...]

Fields of interestCancer Research; Human Genetics



Due February 2013

2nd ed. 2013. XVI, 304 p. 52 illus., 43 in color. (Methods in Molecular Biology, Volume 980) Hardcover7 $139.00ISBN 978-1-62703-286-5

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M. K. Thakur, Banaras Hindu University, Varanasi, India; S. I. Rattan, Aarhus University, Denmark (Eds)

Brain Aging and Therapeutic InterventionsContents Editorial.‑ Contributors.‑ 1 Brain aging: a critical reappraisal.‑ 2 Base excision DNA repair: the house keeping guardian for genomic stability in the brain.‑ 3 Role of brain‑derived neurotrophic factor as a modulator of synaptic plasticity.‑ 4 Mitochondrial dysfunction in sporadic Al‑zheimer’s disease: mechanisms, consequences and interventions.‑ 5 Brain Aging: Influence of early–life events on late‑life brain disorders.‑ 6 The importance of the environment in brain aging: Be happy, live longer.‑ 7 Consequences of altered mortalin expression in control of cell proliferation and brain function.‑ 8 Age induced alterations in biological clock : Therapeutic effects of melato‑nin changes in regulation of biological clock.‑ 9 Neurolipofuscin in aging and aluminum‑induced aging: Possible therapeutic interventions.‑ 10 Dietary restriction as a potential intervention to retard age‑associated impairment of brain func‑tions.‑ 11 Understanding mechanism of action of herbal drugs in age‑related degenerative brain disorders.‑ 12 Neurodegeneration in hypoxia: implications in aging.‑ 13 Stress and memory; from mechanisms to long‑lasting consequences.‑ 14 Estrogen mediated neuroprotection: Hope to combat neuronal degeneration and synaptic plasticity post‑menopause.‑ 15 Potential therapeu‑tic targets for memory impairments and dementia: Clues obtained from memory‑enhanced mice.‑ 16 Potential beneficial effects of a diet with walnuts in aging and Alzheimer’s disease.‑ 17 Smart dietary interventions and prevention of cognitive decline with aging.‑ 18 Herbal cognitive enhancers: New developments and challenges for therapeutic ap‑plications.‑ Index.

Field of interestBiomedicine general



Due October 2012

2012. I, 324 p. Hardcover7 $209.00ISBN 978-94-007-5236-8

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K. L. Tucker, University of Heidelberg, Germany; T. Caspary, Emory University, Atlanta, GE, USA (Eds)

Cilia and Nervous System Development and FunctionCilia are tiny microtubule‑based organelles pro‑jecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long‑neglected organelle in the development and func‑tion of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis.

Features 7 Only book to combine the explosive field of ciliary biology with a focus on the emergent roles of cilia for the central and peripheral nervous systems 7 All chapters written by researchers personally involved in cutting‑edge advancements in the respective field 7 Comprehensive analysis of the multitude of roles played by the primary cilium in neurogenesis and neural function

Contents Introduction.‑ 1 Primary and motile cilia: their ultrastructure and ciliogenesis.‑ 2 Primary Cilia, Sonic Hedgehog Signaling, and Spinal Cord Development.‑ 3 Primary cilia and brain develop‑ment.‑ 4 Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non‑Neuronal Cells.‑ 5 Primary Cilia and Inner Ear Sensory Epithelia.‑ 6 Neuronal Cilia and Obesity.‑ 7 Motile cilia and brain function: ependymal motile cilia development, organization, function and their associated pathologies.‑ 8 Primary Cilia and Brain Cancer.‑ 9 Abnormalities of the Central Nervous System across the Ciliopathy Spectrum.

Fields of interestBiomedicine general; Neurobiology; Neurosci‑ences



Due January 2013


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26

Z. Wang, University of Pittsburgh, PA, USA (Ed)

Androgen‑Responsive Genes in Prostate CancerRegulation, Function and Clinical Applications

Contents Preface.‑ Roles of androgen receptor coregulators and cell signaling in regulation of androgen‑re‑sponsive genes.‑ Selective and classical Andro‑gen Response Elements in androgen‑regulated gene expression.‑ Negative androgen‑response elements in androgen target genes.‑ Chromatin looping and long distance regulation by androgen receptor.‑ The Functionality of Prostate Cancer Predisposition Risk Regions is revealed by AR En‑hancers .‑ Mechanisms of ARE‑independent Gene Activation by the Androgen Receptor in Prostate Cancer Cells: potential targets for better interven‑tion strategies.‑ Androgen action, Wnt signaling, and prostate tumorigenesis.‑ Toward Revealing the Complexity of Androgen Responsive Protein and Non‑coding Transcripts in Prostate Can‑cer.‑ Androgen‑Responsive Gene Expression in Prostate Cancer Progression.‑ Androgen receptor regulated genes in prostate cancer initiation vs metastasis.‑ Androgen‑Independent Induction of Androgen‑Responsive Genes By Interleukin‑6 Regulation.‑ The effect of AR overexpression on androgen signaling in prostate cancer.‑ The expression signature of androgen receptor splice variants and their distinctive transcriptional activities in castration‑resistant prostate cancer.‑ Androgen regulation of the cell cycle in prostate cancer.‑ Androgen Receptor Signaling Interac‑tions Control Epithelial‑Mesenchymal Transition (EMT) in Prostate Cancer Progression.‑ Androgen receptor regulation of serum response factor signaling in prostate cancer. [...]

Fields of interestCancer Research; Gene Therapy; Human Genetics



Due February 2013

2013. X, 365 p. 42 illus., 35 in color. Hardcover7 approx. $189.00ISBN 978-1-4614-6181-4

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A. B. Weir, M. Collins, Charles River Laboratories, Reno, NV, USA (Eds)

Assessing Ocular Toxicology in Laboratory AnimalsOcular toxicity is routinely assessed in toxicol‑ogy studies conducted for regulatory purposes. Ocular anatomy and physiology and the assess‑ment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents.

Features 7 Concise reference addressing ocular anatomy and physiology across species 7 Will enhance the design and interpretation of toxicology stud‑ies conducted for regulatory purposes 7 An overview of routine and advanced techniques that are used to assess ocular toxicity 7 Authoritative, accessible guide for toxicologists and other scien‑tists involved in conducting toxicology studies for regulatory purposes

Contents Comparative Ocular Anatomy in Commonly Used Laboratory Animals.‑ Assessment of Ocular Toxicity Potential: Basic Theory and Techniques.‑ Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals.‑ Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals.‑ Toxico‑logic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment.‑ Toxico‑logic Pathology of the Eye: Alterations of the Lens and Posterior Segment.‑ Nonclinical Regulatory Aspects for Ophthalmic Drugs.‑ Ocular Toxicity Regulatory Considerations for Non‑Drug Food and Drug.

Fields of interestPharmacology/Toxicology; Ophthalmology; Animal Models



Due November 2012

2013. X, 332 p. 112 illus., 86 in color. (Molecular and Integrative Toxicology) Hardcover7 $209.00ISBN 978-1-62703-163-9

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A. Y. Yakovlev, University of Rochester, Rochester, NY, USA; L. B. Klebanov, Charles University, Prague, Czech Republic; D. Gaile, State University of New York at Buffalo, Buffalo, NY, USA (Eds)

Statistical Methods for Microarray Data AnalysisMethods and Protocols

Microarrays for simultaneous measurement of redundancy of RNA species are used in funda‑mental biology as well as in medical research. Statistically,a microarray may be considered as an observation of very high dimensionality equal to the number of expression levels measured on it.

Features 7 Aids scientists in continuing to study micro‑arrays and the most current statistical meth‑ods 7 Provides step‑by‑step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Contents What Statisticians Should Know About Microar‑ray Gene Expression Technology.‑ Where Statistics and Molecular Microarray Experiments Biology Meet.‑ Multiple Hypothesis Testing: A Meth‑odological Overview.‑ Gene Selection with the d‑sequence Method.‑ Using of Normalizations for Gene Expression Analysis.‑ Constructing Multi‑variate Prognostic Gene Signatures with Censored Survival Data.‑ Clustering of Gene‑Expression Data via Normal Mixture Models.‑ Network‑based Analysis of Multivariate Gene Expression Data.‑ Genomic Outlier Detection in High‑throughput Data Analysis.‑ Impact of Experimental Noise and Annotation Imprecision on Data Quality in Microarray Experiment.‑ Aggregation Effect in Microarray Data Analysis.‑ Test for Normality of the Gene Expression Data.

Fields of interestHuman Genetics; Microarrays



Due January 2013

2013. XV, 230 p. 34 illus., 14 in color. (Methods in Molecular Biology, Volume 972) Hardcover7 $119.00ISBN 978-1-60327-336-7

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e‑cell system array comparative genomic methods and … · 2012-10-29 · prominin‑1 (cd133):...

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