e. kennedy - infrared nanoscopy of cells for nanoscale therapeutic agent localization"

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FOI 2013, Murten, 16-18 Sept. 2013

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Page 1: E. Kennedy - Infrared nanoscopy of cells for nanoscale therapeutic agent localization"

FOI 2013, Murten, 16-18 Sept. 2013

Page 2: E. Kennedy - Infrared nanoscopy of cells for nanoscale therapeutic agent localization"

6 6

Page 3: E. Kennedy - Infrared nanoscopy of cells for nanoscale therapeutic agent localization"

Normally…

Mie theory:

Absorbed power:

Page 4: E. Kennedy - Infrared nanoscopy of cells for nanoscale therapeutic agent localization"

• No prism or evanescent wave

• Continual IR intensity monitoring

• Bottom up illumination from a benchtop source.

• Can be combined in situ with other analysis systems

Page 5: E. Kennedy - Infrared nanoscopy of cells for nanoscale therapeutic agent localization"

F. Yarrow, E. Kennedy, F. Salaun, J. H. Rice. Biomed Opt Express. 2011, 2(1): 37–43.

Page 6: E. Kennedy - Infrared nanoscopy of cells for nanoscale therapeutic agent localization"

Rasoul Al-Majmaie et al. Proc. SPIE 8427, 2012

Page 7: E. Kennedy - Infrared nanoscopy of cells for nanoscale therapeutic agent localization"

Nanosensitizer

Page 8: E. Kennedy - Infrared nanoscopy of cells for nanoscale therapeutic agent localization"

Is it legitimate? What can we do? Is it worth it? Is it working?

(a)

Label-free, non-invasive subcellular chemical imaging

E. Kennedy et al. RSC Adv. 2013

Page 9: E. Kennedy - Infrared nanoscopy of cells for nanoscale therapeutic agent localization"

E. Kennedy et al. RSC Adv. 2013