FULLY AUTOMATED COMPACT BENCH-TOP DVS ANALYZER, FOR FAST AND ACCURATE SORPTION MEASUREMENTS.

DYNAMIC VAPOR SORPTION ANALYZER

www.hidenisochema.com

The IGAsorp is a fully automated compact bench-top DVS analyzer, for fast and accurate sorption measurements using the dynamic flow technique for water and organic vapors. The measured vapor uptake and kinetics are used to characterize and understand materials in precisely defined environmental conditions. The IGAsorp has an ultra-sensitive microbalance which measures the weight of the sample as a function of humidity and temperature. Multiple sensors at the sample position allow precise feedback control of the experimental parameters. Humidity is determined by relative mixing of wet and dry gas streams which is measured and regulated at the sample position. The temperature is controlled by active feedback fluid circulation.

TYPES OF MEASUREMENTS THAT CAN BE RECORDED Isotherm and kinetics analysis Cyclic/lifetime studies Moisture content determination Hydrate analysis Permeation and diffusion studies (MVTR) Amorphous phase detection

TYPES OF MATERIALS THAT CAN BE TESTED Polymers Textiles Pharmaceuticals Porous materials Packaging materials Building and construction materials Food products and other consumables Wood, fibres, clays and other natural materials

The IGAsorp uses the unique IGA method for the determination of the sorption kinetics and equilibrium isotherms. This ensures accurate and consistent analysis with faster analysis times making the optimum use of instrument time.

ACCURATE, CONSISTENT, RELIABLE. Providing optimal performance for demanding research applications, method critical quality control, and process analysis.

ACCURATE Unrivalled long term microbalance stability.

Traceable calibration and conformance values.

Built-in user conformance tests for verification of weight, humidity and temperature readings.

System optimized for small sample sizes.

RELIABLE Designed for continuous operation in demanding R&D, process and QC environments.

Minimal operator maintenance required.

On-line embedded video help.

Full 3 year parts and labour warranty as standard.

CONSISTENT Unrivalled temperature and humidity control.

IGA method for objective sorption equilibration determination.

Anodized aluminium sample chamber to eliminate static charge.

Three independent temperature sensors to verify isothermal conditions.

THE IGA METHODThe relative humidity in the sample chamber is ramped to the set point, RHn, and held constant through active control of the wet and dry gas streams.

UPT

AKE

RELATIVE HUMIDITY

TIME

RHn

TIME

En

Equilibrium points are collected and plotted as an isotherm.

The weight change is analyzed in real time to determine kinetic parameters and simultaneously predict the equilibrium point, En.

RHn

En

REL

ATIV

E H

UM

IDIT

YW

EIG

HT

USER-FRIENDLY, VERSATILE.

EXTENDED OPERATING RANGESThe standard IGAsorp analyzer can be readily upgraded to other IGAsorp models, IGAsorp-CT and IGAsorp-HT, offering extended operating temperature and vapor partial pressure ranges, as required.

The IGAsorp offers straightforward and user-friendly operation with pre-programmed methods for routine use, such as materials screening and QC applications. Method templates may also be easily edited to suit individual requirements.The IGAsorp is versatile for advanced users with fully programmable options for detailed and demanding method development. The HIsorp software allows the programming of sample pre-treatments, heating and cooling ramps, multiple set-point temperatures for isotherm determination, and full control over the relative humidity or partial pressure in the sample chamber.

OPTIONS AND ACCESSORIESA range of options and accessories are available including moisture vapor transmission rate (MVTR) cells, organic vapor measurement capability, and an electrically actuated external water feed for extended operation.

HISORP SOFTWAREFully compatible with all MS Windows® operating systems, and featuring an intuitive user interface and high resolution graphics, HIsorp offers the user complete control of the IGAsorp.

HIsorp uses the unique IGA method for real time kinetic analysis, and endpoint prediction. It also incorporates a series of useful and timesaving features including a PDF report generator, single click exports to Excel®, automatic email notification on completion of measurement and on-line video help.

Options include full 21CFR Part II compliance.

TECHNIQUE HYPHENATIONAll IGAsorp models can be interfaced with complementary characterization tools, including Raman and Infrared (IR) probes, optical systems and a range of Hiden Analytical quadrupole mass spectrometers.

EXAMPLE APPLICATION DATA

TIME (MINUTES)

20 40 60 80 100 140120

20

40

60

80

0

%RH

0

20 40 60 80 100 140120

-0.05

0.15

0-0.25

dm/d

t (m

g/m

in)

Figure 1: A simple test used to detect amorphous phase.Data courtesy of GSK

TIME (MINUTES)

50 100 150 200 250

LEGEND FORMAT: H1 | H2 MVTR (ug/cm/hour)

76% | 66% RH MVTR=0.085

76% | 56% RH MVTR=0.123

76% | 46% RH MVTR=0.1494

76% | 36% RH MVTR=0.174

75% | 26% RH MVTR=0.206

76% | 16% RH MVTR=0.241

76% | 6% RH MVTR=0.278

76% | 0% MVTR=0.313

-200

0

WEI

GH

T LO

SS /M

ICRO

GRA

MS

0

Figure 2: MVTR results from a polymer film.Data courtesy of GSK

300

-400

-600

-800

-1000

-1200

-1400

-1600

TIME (MINUTES)

50 100 150 200 250 500300

2

4

6

14

0

WEI

GH

T C

HAN

GE

(%d.

b)

0

Figure 3: Example of isothermal kinetic response data.Reference Hiden Isochema application note 121

0

10

20

30

40

50

60

70

80

90

100

8

10

12

350 400 450

RELATIVE HU

MID

ITY (%)

WEIGHT RH

%RH

Figure 4: Comparision between isotherms at coarse and medium resolution.

Data courtesy of Boehringer Ingelheim Pharma GmbH & Co KG

TIME (MINUTES)

20

40

60

80

%RH

0

Figure 5: Example of a hydration-dehydration cycle.Data courtesy of Pharamaterials Ltd

TOTA

L W

EIG

HT

(MIL

LIG

RA

MS)

500 1000 1500 2000

NUCLEATION DELAY

MONOHYDRATE FORMATION

SURFACE ADSORPTION

RELATIVE HUMIDITY (%)10 20 30 40 50 600

MIC

ROSC

OPI

C D

IFFU

SIO

N C

OEF

FIC

IEN

T

Figure 6: Variation of the microscopic diffusion coefficient with relative humidity.

Reference Hiden Isochema application note 124

70 80

TREATED POLYMER UNTREATED POLYMER

90 100

20 40 60 80 100 140120

37.6

37.7

37.8

37.9

037.5

WEI

GH

T (m

g) Amorphous to crystalline phase transition

WEI

GH

T (%

) WET

BAS

IS

10 20 30 40 50 90600 70 80

0.6

0

0.1

0.2

0.3

0.4

0.5

100

MEDIUM SORPTION RESOLUTION

MEDIUM DESORPTION RESOLUTION

COARSE SORPTION RESOLUTION

COARSE DESORPTION RESOLUTION

GROWTH

TECHNICAL SPECIFICATIONS

WEIGHT Capacity 5 gram Weighing range 25 / 200 / 1000 mg (fixed) or user selectable (optional)Resolution from 0.05 microgramStability nominal +/- 1 microgram / week

HUMIDITY Control range 0 to 98 %RHAbsolute Calibration Accuracy +/-1 % (0-90 %); +/-2 % (90-100 %)Regulation accuracy +/- 0.01 %RHMinimum control increment 0.02 %RHGas Supply Dry air, N2 or HeMaximum flow rate 500 ml/min

TEMPERATURE Measurement range 5 – 50 °CRegulation accuracy +/- 0.01 °CPre-heater Optional, to 250 °C

IGAsorp CTTemperature Measurement range 5 – 85 °CRegulation accuracy +/- 0.01 °CPre-heater Optional, to 350 °C

IGAsorp HTTemperature Measurement range 5 – 300 °CPre-heater Included, to 350 °CWater Vapor Partial Pressure Range 0 – 500 mbar

The IGAsorp is a fully automated compact bench-top DVS analyzer, for fast and accurate sorption measurements using the dynamic flow technique for water and organic vapors.

If you have any questions about IGAsorp or any of Hiden Isochema products or services, please give us a call, we will be happy to help.

Tel: +44 (0) 1925 244 678Email: info@hidenisochema.comWeb: www.hidenisochema.com

Hiden Isochema offers unrivalled technical support free of charge, for the lifetime of the instrument.Telephone and email access to our team of highly qualified engineers with a guaranteed response within 24 hours.3 year warranty as standard.A range of service contracts available.

CONTACT USSUPPORT

FS 535721

IGAsorp