1

Delhi Technological University

(Formerly Delhi College of Engineering Delhi)

Department of Applied Physics

Program M Tech (Nano-Science amp Technology)

Nanotechnology is a rapidly advancing area of scientific and technological opportunity that applies

the tools and processes of nano microfabrication to build devices and study their properties in

nanoscale regime It is a scientific urge to create new micro-nano materials based devices to better

understand their properties in nanoscale regime

To train engineers and scientists with diverse background Applied Physics department has taken

initiative to start the two year ldquoMTech (Nano-science amp technology)rdquo program from the academic

year 2009-2010 The curriculum has been designed in a manner so that students are trained to

various aspects of nanomaterials latest development in the synthesis characterization and

fabrication of nanomaterials based optical and electronic devices Besides the commitment to

trained students in nanotechnology we would like to develop a bridge between research and

industry by taking the discoveries from laboratories and realizing their real-world application

benefit to society

2

COURSE CURRICULUM amp SCHEME OF EXAMINATION

for

MTech (Nano-Science amp Technology) 2017-2018

Semester I Examination November 2017

Semester II Examination May 2018

Semester III Examination November 2018

Semester IV Examination May 2019

Scheme of Examination for MTech Nano-Science and Technology (Offered by Applied Physics Department)

Sem Group Details No of papers

Marks Internal (Each Paper)

Marks External

(Each Paper)

Total Marks (Each Paper)

Semester Total

I A Course work of 3 Core Theory papers 3 50 100 150 1000

(20 Credits)

1 Laboratory 1 30 70 100 B Course work of 2 Core Theory papers 2 50 100 150

1 Laboratory 1 30 70 100 Self study Open area Seminar-I - 50 - 50

II C Course work of 1 Core amp 2 Elective Theory Papers

3 50 100 150 1000

(20 Credits)

1 Laboratory 1 30 70 100 D Course work of 2 Elective Theory papers 2 50 100 150

1 Laboratory 1 30 70 100 Minor project-I - 50 - 50

III E Course work of 2 Elective Theory papers 2 50 100 150 1000

(20 Credits) Self study Open area Seminar-II - 50 50 100

Minor Project-II - 150 150 300 Major Project Part-I - 150 150 300

IV F Major Project Part-II - 500 500 1000 1000

(20 Credits) TOTAL 4000

(80 Credits)

3

COURSE STRUCTURE FOR MTech FIRST SEMESTER (Nano-science amp Technology)

SNo Course No Subject LTP Evaluation Internal External

Total Marks

Credit

1 AP-501 Computational Physics and Programming

300 50 100 150 3

2 AP-502 Chemistry for Nano -science and Technology

300 50 100 150 3

3 AP-503 Physics for Nano-science and Technology

300 50 100 150 3

4 AP-504 Engineering of Materials Laboratory-I 002 30 70 100 2

5 AP-551 Characterization of Materials 300 50 100 150 3

6 AP-552 Fundamental of Nano-science and technology

300 50 100 150 3

7 AP-553 Engineering Materials Laboratory-II 002 30 70 100 2

8 AP-554 Self study Open Area Seminar I 001 50 - 50 1

TOTAL 20 hrs 1000 20

COURSE STRUCTURE FOR MTech SECOND SEMESTER (Nano-science amp Technology)

SNo Course No Subject LTP Evaluation Internal External

Total Marks

Credit

1 AP-601 Physics of Low Dimensional Systems 300 50 100 150 3

2 AP-6021 Materials Science at Nanoscale (Elective-I)

300 50 100 150 3

3 AP-6031 Processing amp Fabrication of Nanostructures (Elective-II)

300 50 100 150 3

4 AP-6511 Nano electronics amp Nano photonics (Elective-III)

300 50 100 150 3

5 AP-6521 Semiconductors Nanostructures amp Devices (Elective-IV)

300 50 100 150 3

6 AP-604 Processing amp Fabrication of Nanostructure Lab

002 30 70 100 2

6 AP-653 Characterization of Materials Science lab

002 30 70 100 2

7 AP-654 Minor Project I 001 50 - 50 1

TOTAL 20 hrs 1000 20

4

COURSE STRUCTURE FOR MTech THIRD SEMESTER (Nano-Science amp Technology)

SNo Course No Subject LTP Evaluation

Internal External

Total

Marks

Credit

1 AP-7011 Nano Electromechanical Materials amp

Devices (Elective-V)

300 50 100

150 3

2 AP-7012 Functional material and device

(Elective-V)

3 AP-7021 Nano Biotechnology (Elective-VI) 300 50 100 150 3

4 AP-703 Self study Open Area Seminar II 002 - 100 100 2

5 AP-704 Minor Project II 006 150 150 300 6

6 AP-705 Major Project I 006 150 150 300 6

TOTAL 20 hrs 1000 20

COURSE STRUCTURE FOR MTech FOURTH SEMESTER (Nano-Science amp Technology)

SNo Course No Subject LTP Evaluation

Internal External

Total

Marks

Credit

1 AP-801 Major Project II - 500 500 1000 20

TOTAL 1000 20

5

SYLLABUS MTech (NanoScience amp Technology)

AP-501 Computational Physics and Programming (3-0-0)

Unit I

A review of the numerical techniques (Interpolations differentiations integrations nonlinear

equations the bisection methods Newtonrsquos method root findings Differential equations Eulerrsquos

method the Runge-Kutta method Matrices-inverting finding eigen values and eigen functions

Bessel functions Hermite Legendre and Lagurre polynomials etc

Unit II

Simple problems based on section-I using Matlab Mathematica (mechanics optics and quantum

mechanics ) Atomistix and related softwares Introduction to Lab view software

Unit III

C++ Programming Introduction to Object oriented Paradigm Basic concept of Object Oriented

Programming (OOP) Benefits of OOP Applications of OOP Classes and Objects- specifying a

class memory allocations for objects static daa members and member functions array of objects

Objects as function arguments friendly Functions returning objects constructors and destructors

Unit IV

Inheritance and Polymorphisms Inheritance types of inheritance Derivation-Public private and

protected polymorphism types of polymorphism- compile time and runtime function overloading

operator overloading virtual functions

References

1 Handbook of Theoretical and Computational Nanotechnology Eds Michael Rieth and Wolfram

Schommers 2006

2 Introductory Computational Physics Kelvin and Godunov (Cambridge)

3 Computational physics RC Verma KC Sharmaamp PK Ahluwalia

4 Introduction to Computer simulations Gould Tobochnik etal (Addition Wesely 2006)

5 Visual basic and C++ Schuam Series

6 Mat labs Programming by Rudrapratap Singh

7 Mathematical Physics Harper

8 Applied mathematics for engineers amp Physicist Pipes and Harvil

9 Numerical Recepies in C The art of scientific Computing WH Press

10 Computer Programming Language Addition Wesely

11 Object oriented Programming in turbo C++ Robert Lafore

6

AP-502 Chemistry for Nano Science amp Technology (3-0-0)

Unit I

Surface adsorption Definition Significance and Applications of it Freudlich and Langmiur

Adsorption Isotherm Gibbrsquos Isotherm Their fundamental approach to Nanomaterials

Unit II

Colloidal chemistry Colloidal properties origin of charge on colloidal properties Determination of

colloidal particle size Synthesis of Nano materialsNano systems employing chemical

precipitation coprecipitation sol-gel synthesis microemulsion thermolysis Electrochemical and

photochemical methods

Unit III

Nano polymersNanocomposites Synthesis Characterization Properties and applications of Nano

polymersNanocomposites ie Polymers metal oxide glass and ceramic based nano composites and

their use in catalysis

Unit IV

Metal and Alloy Nanoparticles Preparation and Stabalization of MetalAlloy nanoparticles particle

size determination particle size distribution their conducting semiconducting and catalytic

properties Separation and purification of Nano particles by Membrane Technology Ion Exchange

Membranes Electrodialysis Reverse Osmosis Ultrafiltration Microfiltration and Nanofiltration

Techniques

References

1 Nanocomposites Science and Technology by PM Ajayan LS Schodler Wiley New York

2 Chemistry of Nanomaterials Synthesis properties and applications by C N R Rao Wiley New York

3 Nanochemistry A chemical approach to nanomaterials- Royal Society of Chemistry Cambridge UK

2005

4 Active Metals preparation Characterization and Application by A Frustner Ed VCH New York 1996

5 Membrane Handbook WSWinston Ho amp Kamlesh K Sirkar Chapman hall (1992)

6 Colloidal Dispersion ndash Russel WB Saville DA Cambridge University Press 1989

7 Surfactants and Polymers In Aqueous by K Holmberg B jonsson B Kromberg Wiley England 2004

7

AP-503 Physics for Nano Science and Technology (3-0-0)

Unit I

Review of fundamentals of Quantum mechanics Schroumldinger equation tunneling density of states

free electron theory of metals The angular momentum problem The spin half problem and

properties of Pauli spin matrices

Unit II

Approximate methods Time independent and time dependent perturbation Theory for non-

degenerate and degenerate energy levels the variational Method WKB approximation adiabatic

approximation sudden approximation

Unit III

Statistical Mechanics Microstates and entropy and its statistical definition Entropy of mixing

Gibbrsquos free energy Gibbrsquos paradox phase space density ergodic hypothesis Liouvillersquos theorem

The microcanonical- canonical- and grand canonical ensemble and their connections Fluctuations

Classical Statistical systems Boltzman statistics and quantum statistical systems Fermi-Dirac and

Bose-Einstein Statistics and their applications (an overview)

Unit IV

Crystal structure crystallographic planes Miller indices Braggrsquos law X-ray Diffraction particle

size determination Confinement and transport in Nanostructures Current reservoirs and electron

channels conductance formula for nanostructures quantized conductance Local density of states

Ballistic transport Coulomb blockade Diffusive transport Fock space Dielectric properties

Polarization ferroelectric behaviour Optical Properties Photoconductivity Optical absorption and

transmission Photoluminescence Fluorescence Phosphorescence Electroluminescence

References

1 Quantum Physics- A Ghatak

2 Quantum Physics of atoms Molecules Solids Nuclei and particles 2nd edition by Eisberg Robert

Resnik Robert

3 Principles of Quantum Mechanics 2nd ed ndash R Shankar

4 Statistical Physics by K Huang

5 Statistical Mechanics- Landau amp Lifshitz

6 Statistical Mechanics- Sonntag

7 Introduction to Solid State Physics- C Kittel Solid State Physics- AJ Dekker

8 The Physics and Chemistry of Solids- Stephen Elliott amp SR Elliot

9 Scanning Probe Microscopy Analytical Methods(NanoScience and Technology)-Roland Wiesendanger

10 Advance X-ray Techniques in Research and Industries ndash AKSingh(editor)

11 Basic Solid State Chemistry ndash Anthony RWest

8

AP-551 Characterization of Material (3-0-0)

UNIT I

X-ray Diffraction Braggrsquos law Application in crystallography Diffractogram Paricle size

determination using XRD

UNIT II

Probe techniques Atomic force Microscopy (AFM) scanning electron microscopy (SEM)

Scanning tunneling microscopy (STM) Transmission Electron Microscopy (TEM) High

Resolution Transmission Electron Microscopy (HRTEM)

UNIT III

Infrared Spectroscopy Raman Spectroscopy Electronic spectroscopy for atoms and molecules

Spin Resonance Spectroscopy Nuclear Magnetic Resonance spectroscopy (NMR)

UNIT IV

Deep level transient spectroscopy (DLTS) Kelvin-probe measurements Nanoscale current-voltage

(I-V) investigations Capacitance-Voltage (C-V) Relationships

References

1 Nanostructures amp Nano Materials Ghuzang Cao

2 Handbook of Nanophase amp Nanomaterials (vol IampII) Zhong Lin Wang

3 Fabrication of fine pitch by holography electron beam lithography and nano-imprint lithography

(proceeding papers) Author(s) Darren Goodchild Simon Wingar Nak Kim

4 Microfabrication and Nanomanufacturing- Mark James Jackson

5 Processing amp properties of structural nanomaterials- LeonLShaw(editor)

6 Fundamentals of molecular spectroscopy C N Banwell Tata McGraw

9

AP-552 Fundamentals of Nano-Science amp Technology (3-0-0)

UNIT I

Introduction and Classification What is nanotechnology The Canvas of Nano Classification of

nanostructures Nanoscale architectures Effects of nanometer length scale Changes to the system

total energy changes to the system structure Nanoscale dimensions and its affects properties

UNIT II

Investigating and manipulating materials at nanoscale Introduction Electron microscopies

Scanning probe microscopies Other kinds of microscopies X-Ray Diffraction Associated

techniques

UNIT III

Fabrication Methods Top Down Processes Bottom Up Processes of Silicon nanowire ZnO

nanowire Carbon nanotubegrapheme Ordering of nanosystems Preparation Safety and Storage

issues Fa

UNIT IV

Society and Nano Societal implications of nanotechnology Introduction From first Industrial

Revolution to the Nano Revolution Issues and outlook Harnessing Nanotechnology for social and

economic development

References

1 Introduction to Nanotechnology Charles PPoole Jr and Frank J Owens

2 Nanotechnology Principles and Practices Sulabha K kulkarni

3 Nanoscale Science and Technology Robert W Kelshall Ian W Hamley and mark Geoghegan

4 NanoThe Essentials ndashUnderstanding Nanoscience and Nanotechnology ndashT Pradeep

5 Handbook of Nanotechnology Bharat Bhusan

10

AP-601 Physics of Low Dimensional Systems (3-0-0)

UNIT I

Maxwell-Boltzmannrsquos statistics Fermi-Dirac statistics and fermions Paulirsquos exclusion principle

Bose Einstein statistics Bosons Bose condensation

UNIT I

Molecular structure Born oppenheimer approximation electronic structure ionic and covalent

bonding H2 H2+ vibrational and rotational structure

UNIT III

Molecular spetra microwave infrared and optical spectra of molecules selection rules suitable

examples

UNIT IV

Transport properties parallel and perpendicular transport quantization of conductance density of

states coulomb blockade kondo effect Hall quantum Hall and fractional Hall effects Other

relevant topics

References

1 Quantum Mechanics by L I Schiff

2 Quantum Mechanics by J L Powell and Crasmann

3 Introduction to Quantum Mechanics by Pauling amp Wilson

4 Quantum Mechanics by A K Ghatak amp S Loknathan

5 The Physics of low-dimensional semiconductors An introduction by J H Davies

6 Concepts of Modern Physics by Arthur Beiser

7 Physics of Molecules by Wolf Gang Demtroder

8 Handbook of Molecular Physics amp Quantum Chemistry by Stephen Wilson

9 Quantum Heterostructures by Maiteir and others

11

AP-6021 Materials Science at Nanoscale (3-0-0)

UNIT I

Single crystalline polycrystalline and amorphous structures crystal structure classification of

crystals imperfection in solids grain boundaries and its effect on mechanical properties Phase

transitions in nanosystems-comparison to large systems

UNIT II

Carbon molecules nature of carbon bonds new carbon structures small carbon clusters C60-

crystal structure larger and smaller fullerenes Buckyballs Carbon Nanotubes-fabrication

structure electrical vibrational and mechanical properties

UNIT III

Applications in field emission shielding computers fuel cells sensors catalysis mechanical

reinforcement

Bulk nanostructured materials synthesis mechanical and electrical properties metal nanocluster

composite glasses porous silicon natural nanocrystals nanoparticles in zeolites crystals of metal

naoparticles nanoparticle lattices in suspensions photonic crystals nanocopmposites

nanoceramics ceramic matrix composites

UNIT IV

Nanostructured ferromagnetism effect of nanostructuring nanomagnets nano carbon ferromagnets

giant and colossal magnetoresistance ferrofluids Nanocmposites of dielectric piezoelectric and

ferroelectric materials Polarization types frequency dependence other relevant current topics

References

1 Materials Science amp Engineering An introduction by W D Callister

2 Introduction to Solid State Physics by C Kittel

3 Solid State Physics by A J Dekker

4 Solid State Physics by Aschroft amp Mermin

5 Nanocomposite Science and Technology by Ajayan Schadler and Braun

6 Principles of Nanotechnology by G Ali Mansoori

7 Nanomaterials Nano-tech amp Design by Michael F Ashby

12

AP-6031 Processing amp Fabrication of Nanostructures (3-0-0)

UNIT I

Fundamental concepts of Bottom-up and top down approaches self assembly and self organization

formation of nanostructure by mechanical milling (ball milling)

UNIT II

Synthesis of carbon nanotubes growth mechanism arc discharge laser ablation sputtering and

growth from solutions and melts

UNIT III

Chemical vapor deposition plasma enhanced CVD thermal CVD vapor phase growth laser

assisted thermal CVD CoMoCat process High pressure CO dispropornation process flame

synthesis pulsed laser deposition (PLD)

UNIT IV

Fabrication of nanoparticles synthesis of colloidal particles synthesis of nanogold particles

synthesis of nanocomposites and nanostructures fabrication of quantum dots nanowires nanorods

nanointermetallics controlled colloidal synthesis Synthesis of polymer supported clusters and

polymeric nanofibers

Nanolithography electron beam and focused ion beam lithographies other relevant current topics

References

1 Nanotechnology by Gregory Timp

2 Introduction to Nanoscale Science amp Technology by M Di Ventra et al

3 Nanophotonics by Paras N Prasad

4 Microlithography Sciences amp Technology ndash Sheats J R and Amith B W (Marcel Dekker Inc New York)

5 Nanolithography A borderland between STM EB IB and X-ray lithographies- M Gentili et al

(Springer)

13

AP-6511 Nano Electronics amp Nano photonic (3-0-0)

UNIT I

Photons and electrons- similarities and differences confinement of photons and electrons

Nanoscale optical interactions-axial and lateral nanoscopic localization quantum confinement

effects cooperative transitions and emission

UNIT II

Quantum well double quantum wells wires dots rings size effects manifestation of quantum

confinement-optical properties conduction electrons and dimensionality potential wells resonant

tunneling and ballistic transport single-electron tunneling infrared detectors quantum dot lasers

UNIT III

Photonic crystals-basic concepts features of photonic crystals photonic crystal optical circuitry

non-linear photonic crystals photonic crystal fibers optical communication and sensors

UNIT IV

Basics of nanoelectronics and molecular electronics break junction nanowires nanocircuits single

molecule magnet molecular conductance molecular logic gate MEMS other relevant topics

Fundamentals of Spintronics spin polarized transport Kondo effect Kubo effect spin relaxation

and injection Spintronics memory devices and applications

References

1 Nanophotonics by Paras N Prasad

2 Introduction to Nanoscale Science amp Technology by M Di Ventra et al

3 Handbook of Photonics by Mool Chand Gupta amp John Ballato

4 Optical properties of photonic crystals by K Sakoda

5 Detection of optical and infrared radiation by Kingston amp Mac Adam

6 Introduction to Nanotechnology by C P Poole Jr and Franks J Owens

7 Spintronics fundamentals and applications by I Zutic and SD Sarma

8 Introduction to spintronics by Supriyo Bandopadhayay

9 Spin electronics by David D Awschalom

10 Quantum Electronics by A Yariv

14

AP-6521 Semiconductors Nanostructures amp Devices (3-0-0)

UNIT I

Basics of semiconductors microelectronic devices and technology silicon technology processing

of III-V semiconductors semiconductor nanoparticles synthesis cluster compounds quantum dots

using MBE CVD and MOCVD

UNIT II

Semiconducting nanoparticles size dependent physical properties band-gap variations-quantum

confinement Fundamentals of carrier transport in quantum structures electrical transport properties

in semiconductors nanostructures temperature effects resonating tunneling diodes structure and

operation of MOS

UNIT III

Small dimension effects Nanoscale MOSFET transistors LED and solar cells Doping nano

particles

Semiconductor nanowires fabrication and integration quantum conductance effects in

semiconductors porous silicon nanobelts nanoribbons nanosprings

UNIT IV

Single electron tunneling superconducting single electron transistor implementation of single

electron transistors applications of single electron transistors other relevant current topics

References

1 Introduction to Nanoscale Science amp Technology by M Di Ventra et al

2 Nanotechnology by Gregory Timp

3 Nanophotonics by Paras N Prasad

4 Introduction to Nanotechnology by C P Poole Jr and Franks J Owens

5 Encyclopedia of Nanotechnology by Hari Singh Nalwa

6 Handbook of Semiconductor Nanostructures amp Nanodevices Volumes-1-5 A A Balandin and K L Wang

7 Nanostructures and Nanomaterials ndash Synthesis Properties amp Applications by Cao amp Guozhong

15

AP-7011 Nano Electromechanical Materials amp Devices (Elective-V (3-0-0)

UNIT I

Introduction of carbon materials Diamond nanodiamond fullerene graphene carbon fiber and

amorphous carbon Synthesis route CVD for synthesis of nanodinamond carbon nanotube and

graphene and other methods of preparation of CNT and graphene

UNIT II

Structure and properties of carbon nanotubes and graphene Electrical Optical Mechanical

Vibrational properties etc

UNIT III

Applications of carbon nanotubes and graphene Biosensors FET Field emission Fuel Cells

Display devices

UNIT IV

Functionalization and purification method for carbon nanotubes Oxidative Purification Defect

Functionalization ndashTransformation and Modification of Carboxylic Functionalization like

Amidation Thiolation Halogenations Hydrogenation Addition of Radicals Addition of

Nucleophilic Carbenes Sidewall Functionlaization through Electrophili Addition Cycloadditions

Carbenes Addition Addition of Nitrenes Noncovalent Exohedral Functionalization Endohedral

Functionalization

References

1 Nanoscale materials -Liz Marzan and Kamat

2 Physical properties of Carbon Nanotube-R Satio

3 Applied Physics Of Carbon Nanotubes Fundamentals Of Theory Optics And Transport Devices - S

Subramony amp SV Rotkins

4 Carbon Nanotubes Properties and Applications- Michael J OConnell

5 CARBON NANOTECHNOLOGY- Liming Dai

6 Nanotubes and Nanowires- CNR Rao and A Govindaraj RCS Publishing

16

AP-7021 Nanobiotechnology (3-0-0)

UNIT I

Biological Methods of Synthesis Use of bacteria fungi Actinomycetes for nanoparticle synthesis

Magnetotactic bacteria for natural spynthesis of magnetic nanoparticles Mechanism of formation

Viruses as components for the formation of nanostructured materials Synthesis process and

application Role of plants in nanoparticle synthesis

UNIT II

Microorganisms for synthesis of nanomaterials and for toxicity detection Natural and artificial

synthesis of nanoparticles in microorganisms Use of microorganisms for nanostructure formation

Testing of environmental toxic effect of nanoparticles using microorganisms

UNIT III

Nanocomposite biomaterials teeth and bone substitution Natural nanocomposite systems as spider

silk bones shells organic-inorganic nanocomposite formation through self-assembly Biomimetic

synthesis of nanocomposite material Use of synthetic nanocomposites for bone teeth replacement

UNIT IV

Nanobio Systems Nanoparticle-biomaterial hybrid systems for bioelectronic devices Bioelectronic

systems based on nanoparticle-enzyme hybrids nanoparticle based bioelectronic biorecognition

events Biomaterial nanocircuitry Protein based nanocircuitry Neurons for network formation

DNA nanostructures for mechanics and computing and DNA based computation DNA based

nanomechanical devices Biosensor and Biochips

References

1 Bionanotechnology Lessons from Nature by David S Goodsell

2 Nanomedicine Vol IIA Biocompatibility by Robert A Freitas

3 Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology - Hari Singh

Nalwa

4 Nanobiotechnology ed CMNiemeyer CA Mirkin

5 Nanocomposite Science amp Technology Ajayan Schadler amp Braun

6 BioMEMS (Microsystems) - Gerald A Urban

7 Introduction to Nanoscale Science and Technology (Nanostructure Science and Technology) ndash

Massimiliano Di Ventra

8 Nanosystems Molecular Machinery Manufacturing and Computation - K Eric Drexler

9 Springer Handbook of Nanotechnology - Bharat Bhushan

10 Nanobiotechnology ed CMNiemeyer CA Mirkin

12 Nanomedicine Vol I Basic Capabilities

13 Nanomedicine Vol IIA Biocompatibility - Robert A Freitas

17

Self-Study Open Area Seminar-I ampII

Compulsory seminar by each candidate on the emerging topics related to nanotechnology

Minor (I ampII) or Major Project

A minor project related to emerging areas in the nanotechnology is to be completed Emphasis will

be given of area related to synthesis characterization and device fabrication Faculty member will

help for selecting area of major projects

Scheme of Examination and Syllabus

MTech in Industrial Biotechnology

Department of Biotechnology Delhi Technological University

Bawana Road New Delhi -110042

MTech in Industrial Biotechnology Biotechnology Industry Organization (BIO) USA has mentioned three major waves in the field of

biotechnology The first wave Green Biotechnology refers to agricultural biotechnology The

second wave Red Biotechnology refers to pharmaceutical and medical biotechnology while the third

wave White Biotechnology refers to industrial biotechnology Industrial biotechnology is mainly

based on biocatalysis (the use of enzymes and cells to catalyse chemical reactions) and fermentation

technology (directed use of micro-organisms) in combination with recent breakthroughs in the

forefront of molecular genetics and metabolic engineering It includes manufacturing of antibiotics

(cephalosporins streptomycin penicillin) food (yoghurt cheese single cell protein mushroom

probiotics) renewable energy (bioethanol biodiesel biohydrogen) health care (growth hormone

antibodies) biopolymers (polyhydroxy butyrate polylactic acid) enzymes (protease lipase amylase

cellulase pectinase xylanase) in various industries (pulp and paper detergent textile food

processing industry) Industrial biotechnology also involved in bioremediation microbial

degradation of pollutants (hydrocarbons polychlorinated biphenyl polyaromatic hydrocarbons)

Biological waste water treatment is undoubtedly one of the most important biotechnological

processes which have been used to treat municipal waste and industrial waste water The proposed

syllabus has been developed to address the need of well trained industrial biotechnologist cutting

edge RampD for this field The trained manpower will be well versed in techniques of protein science

bio-catalysis engineering biosynthesis microbial manufacturing engineering biological systems and

bio-process engineering Moreover they can easily implement these hands on training in industry to

increase the yield more accurately

Delhi Technological University Delhi

Department of Biotechnology

Scheme of Examination

MTech in Industrial Biotechnology

First semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-521 Bioenergy 3 1 0 50 100 150 3

BT-522 Food Engineering

amp Biotechnology

3 1 0 50 100 150 3

BT-523 Enzyme

Engineering amp

technology

3 1 0 50 100 150 3

BT-571 Industrial Plant

Biotechnology

3 1 0 50 100 150 3

BT-572 Bioinstrumentation 3 1 0 50 100 150 3

BT-573 Food engineering

and Biotechnology

Lab

0 0 2 30 70 100 2

BT-524 Bioinstrumentation

Lab

0 0 2 30 70 100 2

BT-574 Self Study open

area seminar-I

0 0 1 50 - 50 1

TOTAL 360 640 1000 20

Second semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-621 Biopharmaceuticals 3 1 0 50 100 150 3

BT-6221 Bioprocess

Engineering

3 1 0 50 100 150 3

BT-6231 Biosensor 3 1 0 50 100 150 3

BT-6711 Nanobiotechnology 3 1 0 50 100 150 3

BT-6721 Environmental

Biotechnology

3 1 0 50 100 150 3

BT-673 Environmental

Biotechnology Lab

0 0 2 30 70 100 2

BT-624 Bioprocess

Engineering Lab

0 0 2 30 70 100 2

BT-674 Minor Project-I 0 0 1 50 - 50 1

TOTAL 360 640 1000 20

Third semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-721 Professional

Elective I

3 1 0 50 100 150 3

BT-722 Professional

Elective II

3 1 0 50 100 150 3

BT-723 Self Study open

area seminar-II

0 0 1 100 100 2

BT-724 Minor Project-II 300 300 6

BT-725 Major Project-I 300 300 6

TOTAL 200 800 1000 20

Fourth semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-821 Major Project-II 400 600 1000 20

TOTAL 1000 20

BT- 721 ELECTIVE SUBJECTS- I

BT-7211 Bioseparation Technology

BT-7212 Industrial waste water treatment

BT-7213 Biopolymer Technology

BT-7214 Bioprocess Plant Designing

BT-7215 Transport Phenomenon

BT-7216 Biochemical Thermodynamics

BT-722 ELECTIVE SUBJECTS- II

BT-7221 Bioethics Biosafety and IPR

BT-7222 Quality Management

BT-7223 Protein Engineering

BT-722 4 Metabolic Engineering

BT-7225 Design and Development of Biological Treatment process

BT-7226 Bioinformatics

SEMESTER I

BT- 521 Bioenergy

Unit-I

Introduction

Global energy scenario Indian energy scenario types of energy sources description of Biofuels

various Biofuels Bioenergy from biomass Biofuel Production Alternative Biochemical Pathways for

Organo-heterotrophic Lithotrophic and Phototrophic Metabolism Importance of biofuel feed stocks

Cellulose starch sugar Lignocellulosic Agro and Industrial by-products

Unit-II

Production of Bio-ethanol

Process Technology for Bioethanol production using Sugar Starch and Lignocellulosic Selection of

micro-organisms and raw materials Unit Operations in Alcohol production Continuous

fermentation Distillery quality control Alcohol distillation

Unit-III

Production of Biodiesel

Chemical Thermodynamic and Reaction Kinetic Aspects of Biodiesel Production Lipids as a source

of biodiesel Methods of Biodiesel Production ndash General procedure and large scale production

Quality Control Aspects Biodiesel production from microalgae and future prospects

Unit-IV

Production of Biohydrogen

Biohydrogen production by anaerobic bacteria and photosynthetic algae Enzymes involved in

biohydrogen Production Biochemical Pathway Batch Fermentation Factors affecting biohydrogen

production Carbon sources Process and Culture Parameters Detection and Quantification of

biohydrogen

Unit-V

Microbial Fuel Cells

Introduction and biochemical basis History of microbial fuel cell development Microbes used in

microbial fuel cells Design of microbial fuel cells MFC components Two and Single MFC systems

Stacked microbial fuel cell Performances of microbial fuel cells Ideal performance Actual MFC

performance Effects of operating conditions pH buffer and electrolyte Proton exchange system

Operating conditions in the anodic chamber Operating conditions in the cathodic chamber

Applications Electricity generation Biohydrogen Wastewater treatment Biosensor MFCs in the

future

Unit-VI

Case studies

Text books

1 Caye M Drapcho NP Nhuan and T H Walker Biofuels Engineering Process Technology Mc

Graw Hill Publishers New York 2008

2 Jonathan RM Biofuels ndash Methods and Protocols (Methods in Molecular Biology Series) Humana

Press New York 2009

3 Lisbeth Olsson (Ed) Biofuels (Advances in Biochemical EngineeringBiotechnology Series

Springer-Verlag Publishers Berlin 2007

BT- 522 Food Engineering and Biotechnology

Unit- I

Food chemistry

Food chemistry-definition and importance Composition of foods and function of water

carbohydrates proteins amino acids lipids vitamins and shelf life of food Bioavailability and

stability of nutrients Nutritive value of foods Food as a source of energy Food Health and diseases

Unit ndash II

Food Microbiology

History and significance of microorganisms in foods Biotechnological improvements catabolic

repression Microbial growth pattern Biochemical changes caused by micro-organisms deterioration

of various types of food product Food poisoning and microbial toxins standards for different foods

Food borne intcericants and mycotoxius

Unit ndashIII

Fermentation products

Dairy products Production of starter cultures Cheese - principles of cheese making Cheddar

Cheese Swiss Cheese Surface ripened Cheeses Mold ripened Cheeses General principles of

manufacture of Kefir Fermented foods Soy sauce Miso Sufu Natto Idli fermented fish products

Fermented vegetables Sauer Krant pickles Olives Fermented sausages Distilled beverages

Alcohol wine brandy and beer Food additives organic acid (acetic acid lactic acid and citric acid)

amino acids (glutamic acid lysine threonine arginine and histidine) food flavourants and pigments

Unit ndashIV

Food Preservation and storage

General principles underlying spoilage and chemical changes of food caused by microorganisms

(Staphylococcal Salmonellosis Ecoli) food spoiling enzymes Botulism toxin production and

deterioration of foods Principles of food preservation by physical methods (irradiation drying heat

processing chilling and freezing high pressure and modification of atmosphere) by chemical

methods and biological methods Storage Stability Food Preservation with Low Temperatures Food

Preservation with High Temperatures Preservation of Foods by Drying Indicator and Food-borne

Pathogens

Unit V

Food process technology

Packaging and canning of foods ndash preparation for packaging thermal processing of foods

Microwave heating thermal inactivation of microorganisms thermal process evaluations freezing

and thawing of foods Food process operations Evaporation single and multi effect evaporation

dehydration psychomatric charts drying-tunnel tray spray drum freeze distillation food

processing aid through biotechnology Food sanitation Good manufacturing practices ndash Hazard

analysis Critical control points Personnel hygiene

Unit ndashVI

Food Processing and Quality assurance

Basic principles unit operations and equipment involved in the commercially important food

processing methods and unit operations materials and containers used in food packaging Objectives

importance and functions of quality control Methods of quality assessment of food materials-fruits

vegetables cereals dairy products meat and poultry Food regulations grades and standards

Concept of Codex AlmentariousHACCPUSFDAISO 9000 series etc Food laws and standards

Text Books

1 Frazier WS and Weshoff DC Food Microbiology 4th Edn McGraw Hill Book Co New

York 1998

2 Mann amp Trusswell Essentials of human nutrition 3rd edition oxford university press 2007

3 Prescott and Dunns Gerald Reed Industrial Microbiology 4th Edition AVI Publishing Company

Inc Conneticut 1983

4 BSivashankar ndash Food processing and preservation Prentice ndash Hall of India PvtLtdNew Delhi

2002

BT- 523 Enzyme Engineering and Technology

Unit-I

Introduction to enzymes

Introduction nomenclature and classification of enzyme Mechanism and catalysis concept of active

site and energetics of enzyme substrate complex formation specificity of enzyme action principles

of catalysis ndash collision theory transition state theory role of entropy in catalysis Biocatalysis in

organic liquids Enzymatic catalysis in biphasic system Ribozyme Abzyme (catalytic antibodies)

Biosynthesis and regulation of enzyme in microorganism

Unit-II

Enzyme Kinetics

Kinetics of substrate and multisubstrate reactions King-Altmanrsquos method Analysis of kinetic data

Inhibition - substrate product and inhibitors Active and legend binding sites Allosteric regulation of

enzymes Monod changeux wyman model deactivation kinetics Molecular folding and defolding of

enzymes

Unit - III

Enzyme immobilization

Methods of immobilization External and internal diffusional mass transfer limitation Effectiveness

factor and modulus electrostatic and stearic effects in immobilized enzyme systems

Unit-IV

Enzyme Reactor

Reactors for Batch continuous enzymatic processing choice of reactor type idealized enzyme

reactor systems Mass transfer in enzyme reactors Steady state analysis of mass transfer and

biochemical reaction in enzyme reactors

Unit ndashV

Purification and Characterization of enzymes from natural source

Production and purification of crude enzyme extracts from plant animal and microbial sources

methods of characterization of enzymes

Unit-VI

Application of enzymes

Application of enzymes in different industries (Pulp and Paper industry Detergent industry Textile

industry Food processing industry) Medical and analytical application of enzyme Biosensor

Text books

1 Enzymes A Practical Introduction to Structure Mechanism and Data Analysis by RA Copeland

Publisher John Wiley and Sons Inc

2 Enzymes by Palmer (2001) Horwood Publishing Series

3 Introduction to Biocatalysis using Enzymes and Microorganisms by SM Roberts NJ Turner and

A J Willetts Publisher Cambridge University Press

4 Fundamentals of Enzymology by Price and Stevens (2002) Publisher Oxford University Press

5 Enzyme Technology by Helmut Uhling (1998) Publisher John Wiley

6 Introduction to Proteins Structure by Branden and Tooze (1998) Publisher Garland Publishing

7 Enzyme Kinetics Behavior and Analysis of Rapid Equilibrium and Steady - State Enzyme

Systems by IH Segel Publisher Wiley-Interscience

BT-571 Industrial Plant Biotechnology

Unit-I

Plant genome organization

Organization and features of mitochondrial nuclear and choloroplast genome ndash Structural features of

gene families in plants

Unit-II

Plant cell cultivation

Callus cultures cell cultures and protoplast cultures Micropropagation Organogenesis and somatic

embryogenesis Cell suspension culture Ovule culture Anther culture Production of haploids

Protoplast isolation and fusion Selection systems for somatic hybridscybrids Somaclonal variation

Preservation of germplasm Formation of Secondary Metabolites in Tissue Culture Production of

pharmaceuticals by tissue culture pigments perfumes flavors insecticides flavonoids

Biotransformation using plant cell cultures Bioreactor system and models for mass cultivation of

plant cells hairy root culture Quality assurance and quality control

Unit-III

Transgenic plant and application

Transgenesis in plants Gene transfer in plants ndash Gene transfer through vectors - Biology of vectors

used - Ti and Ri plasmids binary vectors viral vectors cloning strategy and method of gene transfer

Vectorless gene transfer ndash electroporation and gene gun method DNA bar coding Application of

transgenic plants Virus resistance coat protein mediated nucleocapsid gene Nematode resistance

Abiotic stress Drought cold and salt Post-harvest losses long shelf life of fruits and flowers use of

ACC synthase polygalacturanase ACC oxidase male sterile lines bar and barnase systems

carbohydrate composition and storage ADP glucose pyrophosphatase RNAi and Reverse genetics

Unit- IV

Natural Resource Management

Different approaches of Biodiversity Conservation Biotechnological Characterization and strategies

for the conservation of different populations of endangered plants Molecular markers and genetic

diversity screening

Unit-V

Plant metabolism Metabolomics and metabolic engineering

General concepts of metabolism Introduction to databases from plant transcriptomics to

metabolomics

Unit VI

Industrial applications

Industries engaged in tissue cultureplant cell suspension culture their working and management

Pharmaseutically useful metabolites generated by suspension cultures

Text books

1 Dixon RA and Gonzales Plant Cell Culture A Practical Approach IRL Press 1995

2 Lindsey K and MGK Jones Plant Biotechnology in Agriculture Prentice Hall New Jersey

1990

3 Biotol series In vitro Cultivation of Plant cell Butterworth Heinemann Ltd 1994

4 Ranga MM Animal Biotechnology (3e) Agrobios 2007

5 Bhojwani amp Rajdhan Animal and Plant Biotechnology Elsevier 1996 )

6 Gene cloning amp DNA Analysis An introduction by T A Brown Fourth edition (2001)

7 Genetic Engineering by S Rastogi and N Pathak Publishers Oxford University Press(2009)

8 Principles of Gene Manipulation amp Genomics by Primrose amp Twyman Seven edition (2006)

BT- 572 Bioinstrumentation

Unit I

Electrochemistry Temperature pH buffers Conductivity Dissolved oxygen carbon dioxide

Unit II

Centrifugation Basic principle and application Analytical and Preparative centrifuges and ultra

centrifugation

Unit III

Electrophoretic Techniques Paper and gel electrophoresis Immuno electrophoresis isoelectric

focussing two-dimensional electrophoresis capillary electrophoresis

Unit IV

Chromatographic Methods Paper TLC gas chromatography gel filtration ion exchange

chromatography affinity chromatography and HPLC FPLC

Unit V

Spectroscopy UVvisible and NIR spectrofluorimetry Atomic absorption spectrophotometryMass

Spectrometry Infrared and Raman SpectroscopyNuclear Magnetic Resonance and Electron Spin

Resonance spectroscopy

Unit VI

Microscopy Principle parts types and functioning of Microscope Optical and Electron

Microscopy Transmission and Scanning Electron Microscopy Tunneling Electron Microscopy

Atomic Force Microscopy Fluorescence microscopy Confocal microscopy

Text books

1 Principles and Techniques of Practical Biochemistry by Keith Wilson and JohnWalker Cambridge

University Press

2 Biophysical Chemistry The conformation of Biological Macromolecules by CRCantor and PR

Schimmel Publisher WH Freeman

Reference books

1 Essentials of Biophysics by P Narayanan Publishers New Age InternationalPublishers

2 Introduction to Spectroscopy by DL Pavia GM Lampman and G S Kriz Publisher Brooks

Cole

3 Physical Chemistry of Macromolecules by C Tanford Publisher John Wileyand Sons Inc

4 Principles of Physical Biochemistry by KE Van Holde Publisher Prentice Hall

BT-524 Lab- Bioinstrumentation 1 Measurement and control of pH 2 Measurement of conductivity of a given sample

3 Measurement of conductivity and dissolved oxygen in given sample

4 Protein quantification

5 Protein separation through electrophoresis

6 Sample preparation for light microscopy and Electron Microscopy

7 Quantification of DNA RNA Lipid Fatty acids

8 Sample analysis through AAS

9 Sample preparation for Fluorescence and Confocal microscopy

10 Isolation of DNA and analysis by gel electrophoresis

BT-573 Lab- Food Engineering and Biotechnology

1 Isolation of industrially important microbes

2 Production of fermented product

3 Comparative studies of ethanol production using different substrates

4 Production of wine

5 Production of citric acid

6 Detection of adulterants in food

7 Mushroom cultivation

8 Bread making

9 Colourant production

10 Studies of different methods of food preservation

11 Estimation of carbohydrates and proteins

BT-574 Self Study Open Area Seminar-I

SEMESTER II BT- 621 Biopharmaceuticals

Unit-I

Drug metabolism Oxidation reduction hydrolysis conjugation Need for developing new drugs

Procedure followed in drug design Molecular modification of lead compounds Prodrug and soft

drugs Physico-chemical parameters in drug design QSAR Active site determination of enzymes

Design of enzyme inhibitors

Unit-II

Pharmacokinetics and Drug discovery

Biotransformation of drugs Preclinical Pharmacokinetics Compartment modelingone compartment

open model two compartment open model multi compartment model non linear kinetics

bioavailability and bioequivalence excretion of drugs pharmacokinetics ndash effects of food and

fasting Substances derived from bacteria plants insects and animals Sources of active principles

Assay systems and models (eg Knock-out Mice) Protein molecular modeling by computer

Docking studies Structure based drug designing using software

Unit-III

Pharmaceutical dosage forms

Dosage Forms and Basic Preparations Excipients for Pharmaceutical Dosage Forms Compressed

tablets wet granulation dry granulation or slugging direct compression tablet formulation coating

capsules sustained action dosage form parental oral liquids ointments recombinant blood products

and therapeutic enzymes hormones of therapeutic interest Pharmaceutical products Analysis and

Control laxatives ndash analgesics ndash non steroidal contraceptives ndash external antiseptics ndash antacids and

other antibiotics ndash biological ndash hormones ndash vitamins - preservation analytical methods and test for

various drugs and pharmaceuticals packaging techniques ndash quality control

Unit-IV

Pharmaceutical products and products of DNA technology

Microbial products - Antibiotics (penicillin streptomycin tetracycline) vitamins probiotics Plant

secondary metabolites - control mechanism and manipulation of pheny-propanoid pathway and

shikimate pathway Tissue culture production of alkaloids flavanoids steroids terpenoids animal

vaccines Pharmaceutical products of DNA technology Therapeutic proteins ndash Insulin human

growth hormone clotting factors interferons interleukins tissue plasminogen activators

erythropoietin DNAseI alginate lyase muteins Production advantages limitations and applications

of monoclonal antibody Oligonucleotides and Gene therapy ras-Antisense therapy gene delivery

system Vector usage strategies for gene therapy Clinical trials

Unit-V

Drug safety evaluation

Strategy and Phasing for Drug Safety Evaluation in the Discovery and Development of

Pharmaceuticals Regulation of Human Pharmaceutical Safety Acute Toxicity Testing in Drug

Safety Evaluation Special Concerns for the Preclinical Evaluation of Biotechnology Products

Immunotoxicology in Pharmaceutical Development The Application of In Vitro Techniques in Drug

Safety Assessment Pharmaceutical Quality Assurance

Unit-VI

Patenting process in drug manufacturing process

Patenting- Patent types The patent application Patenting in biotechnology Preclinical trials Clinical

trials The role and remit of regulatory authorities-The Food and Drug Administration The

investigational new drug application The new drug application European regulations Guides to

good manufacturing practice Formulation and Delivery Issues of Therapeutic Proteins

Biotechnology-Derived Drug Products Formulation Development Stability Testing Filling and

Packaging

Text books

1 Heinrich Klefenz Industrial pharmaceutical biotechnology John Wiley sons 2002

2 Susanna Wu-Pong Yongyut Rojanasakul and Joseph Robinson Biopharmaceutical drug and

design and development Humana Press 2007

3 Gary Walsh Biopharmaceuticals Biochemistry and Biotechnology (2e) John Wiley amp Sons

2003

4 Herbert A Kirst Wu-Kuang Yeh Milton J Enzyme Technologies for pharmaceutical and

biotechnological applications WILEY-VCH Verlag 2003

BT- 6221 Bioprocess Engineering

Unit I

Media design and Sterilization kinetics

Criteria for good medium medium requirements for fermentation processes carbon nitrogen

minerals vitamins and other complex nutrients oxygen requirements medium formulation of

optimal growth and product formation examples of simple and complex media medium

optimization methods ndash Plackett and Burman and Response surface method Thermal death kinetics

of microorganisms batch and continuous heat sterilization of liquid media design of sterilization

equipment-batch and continuous ilter sterilization of liquid media air sterilization

Unit II

Metabolic stoichiometry and energetics

Stoichiometry of cell growth and product formation elemental balances degrees of reduction of

substrate and biomass available electron balances yield coefficients of biomass and product

formation maintenance coefficients energetic analysis of microbial growth and product formation

oxygen consumption ndash steps involved in the transfer of oxygen to broth and heat evolution in aerobic

cultures

Unit III

Growth and Production kinetics

Kinetic models for microbial growth Monod model growth of filamentous organisms product

formation kinetics - leudeking-piret models substrate and product inhibition on cell growth and

product formation Production kinetics Design for single and multiple reaction size comparisons of

single reactor for single reactions multiple reactor systems for single reaction reactions in parallel

in series and seriesparallel reactions of first order Heterogeneous reactions kinetics and mechanism

of heterogeneous non catalytic and catalytic reactions Non ideal flow - residence time distribution

studies CE F and I curves RTD in ideal reactors Models for Non ideal flow ndash zero ndash parameter

model One parameter model and two parameter model

Unit IV

Types and design of bioreactor

Construction material Basic components ndash Agitator aerator valves and steam traps seals stirrer

glands Stirred tank batch bioreactor stirred batch bio reactor for enzymes cell cultures Continuous

Stirred Tank Bioreactor Continuous operation of mixed reactor enzyme reactions in a mixed

reactor substrate inhibition kinetics and product inhibition kinetics chemostat with cell cultures ndash

steady state cell and substrate concentrations and productivity as a function of dilution rate CSTR

with immobilized enzymes operation of CSTR in a constant feed rate policy-simulation for

conversions with and without diffusion limitations chemostat in series Graphical design Plug Flow

and Packed Bed Bioreactor Performance equation with Michelin-Menten kinetics substrate

inhibition and product inhibition plug flow reactor for immobilized enzymes operation of plug flow

reactor in constant feed rate policy simulation for conversion with and without diffusion limitations

Fedndashbatch reactor Applications of fed reactor Fed batch operation of mixed reactor material

balance on cell and substrate Recycle system Chemostat with recycle Biological waste water

treatment Feed forward control of the activated sludge process The Transient Behavior of

Bioreactors Stability analysis Stability of the chemostat Stability of chemostat with substrate

inhibition Operating diagram Transient responses of the chemostat control of the chemostat

Turbidostat operation Nutristat operation

Unit V

Instrumentation and Control

Biochemical process variables and their measurements Control principles and their application in

bioreactors Theory of electrode processes and their applications Measurement and control of pH

temperature dissolved oxygen aeration and agitation redox potential foam etc On-line analysis of

process parameters Introduction to biosensors Transduction principles used in biosensors

Characteristics of biosensors Biosensors based on amperometric potentiometric thermistor FET

fiber optics and bioluminescence Microbial biosensors Fundamentals of digital process control Use

of computer in control and optimization of microbiological processes

Unit VI

Downstream processing

Removal of microbial cells and solid matter foam separation precipitation filtration centrifugation

cell disruptions liquid-liquid extraction chromatography membrane process drying and

crystallization Quality analysis and product formulation - Product appearance product stabilization

shelf life analysis usage specific formulations quality analysis and control

Text books

1 Biochemical Engineering Fundamentals by JE Baily and DF Ollis Publisher McGraw Hill

(1986)

2 Biochemical Engineering by SAiba AE Humphry and NF Millis Publisher University of

Tokyo press(1973)

3 Bioreaction engineering principles by J Nielson and J Villadsen Publisher Plenum Press (1994)

4 Chemical Engineering Design Fourth edition by JM Coulson and JF Richardson Publisher

Butterworth Heinemann(2005)

5 Bioprocess Engineering- Kinetics Mass transport reactors and gene expression by WR Veith

Publisher John Wiley and Sons Inc(1994)

6Bioprocess Engineering Basic Concepts by ML Shuler and F Kargi Publisher Prentice Hall

(1987)

7Bioprocess engineering principles by P Doran Publisher- Academic press (1995)

BT-6231 Biosensor Unit-I

Introduction

A historical perspective Definition and Expanding Needs of Biosensors Advantages and limitations

Biosensor Economics various components of biosensors

Unit-II

Types of Biosensors

Biocatalysts based biosensors bio affinity based biosensors amp microorganisms based

biosensors biologically active material and analyte Types of membranes used in

biosensor constructions

Unit-III

Transducers in Biosensors

Various types of transducers principles and applications Bio- chemi- and lectrochemiluminescence

for fiber-optic biosensors Fluorescence-based fiber-optic biosensors

Unit-IV

Electrical Signal Detection in Biological Systems

Silicon glass and metal electrodes amplifier design Bioelectronic device production

microelectronic fabrication methods as adapted to bioelectronics hard and soft lithography bio-

compatibility of materials Existing types of Biosensors Miniaturisation and micro-systems

including sensing using optical techniques field effect transistors ion-selective and enzymatic

sensitive electrodes as well as impedance monitoring

Unit-V

Kinetic modeling for biosensors

The purpose and practice of modeling The flux equations The flux diagram for the membrane

enzyme electrode Deriving a complete kinetic model Kinetic modeling in other types of

biosensors- Potentiometric enzyme electrodes Optical and photometric biosensors Immunosensors

Unit-VI

Application and Uses of Biosensors

Biosensors in medicine and health care (For glucose monitoring and for DNA analysis Analysis of

the neural cell impulse signal and neural signal processing) biosensors for agriculture and food Low

cost- biosensor for industrial processes for online monitoring biosensors for environmental

monitoring

Text books

1 Rajmohan Joshi Biosensors (1e) Gyan Books 2006

2 Cooper JM and Anthony EG Biosensors (2e) Oxford University Press 2004

3 Turner APF KarubeI and WilsonGS Biosensors Fundamentals and applications Oxford Univ

Press 1990

4 SadanaA Biosensors Kinetics of Binding and Dissociation Using Fractals (1e) Elsevier BV

1995

5 Ashok M and Kim Rogers Enzyme amp Microbial Biosensors Techniques and Protocols (Methods

in Biotechnology) (1e) Humana Press 1998

6 Ashok M and Kim Rogers Affinity Biosensors Techniques and Protocols (Methods in

Biotechnology) (1e) Humana Press 1998

7 Damia Barcelo Biosensors for the Environmental Monitoring of Aquatic Systems Bioanalytical

and Chemical Methods for Endocrine Disruptors (1e) Springer 2009

BT-6711 Nanobiotechnology

Unit-I

Introduction

Nano - definition The fundamental Science behind nanotechnology- electrons atomsand ions

molecules metals biosystems Synthesis and Characterizations of Nanoscale Materials Strategies for

Nano architecture (top down and bottom up approaches) Fabrication Technologies and

Characterizations Self-assembly Systems Basic aspects of Nanofluidics surfactants polymers

emulsions and colloids Nanoscale Artificial Platforms Lipids in Self-assembly Structures

Nanoparticle synthesis in plants bacteria and yeast and its applications

Unit-II

Nano-structured materials

Fullerenes - Properties and CharacteristicsCarbon Nanotubes - Characteristics and Applications

Quantum Dots and WiresGold Nanoparticles Nanopores carbon nanotubes Applications of

NanoMolecules in Biosystems

Unit-III

Structural and functional principles of nanobiotechnology

Structural principle Factors governing biomolecular structure and stability Protein folding Self

assembly Self-organization Molecular recognition and Flexibility of biomaterials Functional

principles of Bionanotechnology Information driven nanoassembly Energetics Role of enzymes in

chemical transformation allosteric motion and covalent modification in protein activity regulation

Structure and functional properties of Biomaterials Bimolecular motors ATP Synthetase and

flagellar motors Traffic across membranes Potassium channels ABC Transporters and

Bactreriorhodapsin Bimolecular sensing Self replication Machine-Phase Bionanotechnology

Unit-IV

Bionanomachines and their Basic

Negligible gravity and inertia atomic granularity thermal motion water environment and their

importance in bionanomachines The role of proteins amino acids nucleic acids lipids and

polysaccharides in modern biomaterials Overview of natural Bionanomachines Thymidylate

Sythetase ATP synthetase Actin and myosin Opsin Antibodies and Collagen

Unit-V

Biophotonics and Bioimaging

Overview of imaging biological systems from the cellular level through to wholebody medical

imaging Introduction to biophysics basic physical concepts in imaging Major techniques using

ionizing and non-ionizing radiation fluorescence and multi-photon microscopy spectroscopy OCT

MRI X-ray CT PET and SPECT imaging

Unit-VI

Application of Nanobiotechnology

Nano-biotechnology in drug Delivery Nanoscale Devices for Drug Discovery Micelles for Drug

Delivery Protein targeting Small Molecule-Protein Interactions Micro-array and Genome Chips

Nanotechnology and the Cell Cell Motility Nano Motors and Cellular Navigation hemotaxis -

Transmembrane Signalling and Related Protein Nanotechnology for Cancer Diagnostics and

Treatment Nanotechnology for Cancer Research and Therapy siRNA Tumor-targeted Drug

Delivery Systems Nanotechnology for Imaging and Detection

Text Books

1 NANO by TPradeep 2006Tata Mc Graw Publishers India

2 Nanobiotechnology Concepts Applications and Perspectives Christof MNiemeyer Chad

AMirkin (eds) Wiley-VCH Weinheim (2004)

3 Kamali Kannangara Geoff Smith Michelle Simmons Burkhard Raguse

4 Overseas Press (2005)

5 David S Goodsell Bionanotechnology John Wiley amp Sons 2004

6 Greco Ralph S Nanoscale Technology in Biological Systems CRC Press 2005

BT-6721 Environmental Biotechnology

Unit-I

Basic concepts of ecology Interaction between environment and biota Concept of habitat and

ecological niches Limiting factor Energy flow food chain food web and trophic level NPC and S

cycles in nature Ecosystem dynamics and management Environmental impact assessment

Principles of conservation Conservation strategies sustainable development Global environmental

problems ozone depletion UV-B radiation green house effect and acid rain their impact in

biotechnological approaches for management

Unit-II

Environmental pollution

Types of pollution and pollution analysis ndash noise air and gaseous pollution Noise pollution Source

measurement impact on ecosystem and control Air pollution Types source method of sampling

measurement impact on ecosystem and control Control of noise and air pollution by

biotechnological methods Gaseous pollutants and odours General sources methods of control

fundamentals of adsorption mechanism of adsorption equilibrium isotherms break through curve

adsorption equipment regeneration of adsorbent application of adsorption for control of gaseous

and odour emission

Unit-III

Water pollution Impurities in water water pollution by industrial waste examination of water

collection of water samples water analysis ndash physical chemical and biological Standards of water

quality Water treatment processes Primary treatment screening skimming with coagulants

flocculation filteration aeration and disinfection Secondary treatment Aerobic processes ndash

activated sludge oxidation ditches recirculating system trickling filter towers rotating discs

rotating drums oxidation ponds Anaerobic digestion anaerobic filters Up flow anaerobic sludge

blanket reactors Tertiary treatment Activated carbon treatment reverse osmosis and electro dialysis

Unit-IV

Bioremediation

In situ and ex situ bioremediation technologies for various pollutants and sites bioremediation of oil

spills and heavy metal pollution use of microbes in bioremediation hydroponic system pollution

control boards and pollution control acts

Unit-V

Solid waste management sewage sludge treatment and utilization refuse disposal excreta disposal

in unsewered area composting and vermiculture biodegradation of noncellulosic wastes for

environmental conservation and fuel bioconversion of cellulosic wastes into protein and fuel

bioremediation of contaminated soils and waste lands radioactive product waste disposal

Unit-VI

Effluent treatment Sources of pollution impact on ecosystem and treatment of following industrial

effluents starch paper and pulp tannery dairy distillery oil refineries and pharmaceutical

Microbes in mining ore leaching oil recovery biopolymers biosurfactants

Text Books

1 Bruce E Rittmann and perry L Mccarty ldquoEnvironmental Biotechnology Principle and

Applicationsrdquo McGraw Hill publishing company Ltd2001

2 Mecalf and Eddy Inc ldquoWastewater Engineering Treatment Disposal Reuserdquo McGraHill

publishing company Ltd1991

3 Des W Connell ldquoBasic concepts of Environmental chemistryrdquo Lewis publishers2005

4 Michal J PelczarECS ChanNoel RKriegTata McGraw Hill publishing company Ltd1993

5 Alan Scragg Environmental BiotechnologyOxford University press2005

6 Prescott Harley Klein Microbiology WCB publishers1996

7 Richard T Wright and Bernard J Nebel ldquoEnvironmental Science towards a Sustainable Futurerdquo

Prentice Hall of India 2004

BT-624-Bioprocess Engineering Lab

1 To determine the concentration of protein content by Lowry method

2 To determine the concentration of sugar by 3 5 dinitrosalicylic acid method

3 To determine the optimum pH for given enzyme sample

4 To determine the optimum temperature for given enzyme sample

5 To study the immobilization of invertase enzyme

6 Measurement of citric acid production by Aspergillus niger with TLC

7 Determination of thermal death point (TDP) of the given microorganism

8 Production of ethanol from yeast fermentation of sugars

9 To prepare the growth curve of micro-organism cultured in a shake flask

10 To study the kinetics of lipase enzyme

BT-673- Environmental Biotechnology Lab 1 Environmental Impact Assessment Measurement of Air and Noise Pollution

2 Analysis of water temperature and pH

3 Measurement of Conductivity and TDS in water

4 Measurement of Dissolved Oxygen

5 Measurement of Carbondi Oxide and Hardness of water

6 Measurement and analysis of Ammonia and Ammonium in water

7 Measurement of Nitrite Nitrate and Total Nitrogen in water

8 Biochemical Oxygen Demand and Chemical Oxygen Demand measurements and analysis

9 Analysis of any one industrial effluent

10 Production of methane from sewage sludge

11 Vermicomposting

BT-674 Minor Project- I

SEMESTER III

BT-721 1 Elective ndash Bioseparation Technology Unit- I

Role of Downstream Processing in Biotechnology

Role and importance of downstream processing in biotechnological processes Problems and

requirements of bioproduct purification Economics and downstream processing in Biotechnology

Cost cutting strategies characterstics of biological mixtures process design criteria for various

classes of bioproducts (high volume-low value products and low volume- high value products)

physicochemical basis of bioseparation processes

Unit- II

Primary Separation and Recovery Processes

Cell disruption methods for intracellular products removal of insolubles biomass (and particulate

debris) separation techniques flocculation and sedimentation centrifugation and filtration methods

Precipitation methodsPrecipitation with salts organic solvents amp polymers

Unit- III

Extraction

Batch extractions staged extractions-cross current co current counter current extractions

Differential extractions fractional extractions with a stationary phase fractional extractions with two

moving phases Aqueous two-phase extraction reverse micelle extraction supercritical fluid

extraction in-situ product removalintegrated bioprocessing

Unit- IV

Membrane-based separations (micro- and ultra-filtration)

Theory design amp configuration of membrane separation equipment applications

reverse osmosis dialysis electro dialysis Isoelectric focusing

Unit- V

Adsorption

Adsorption isotherms industrial adsorbents adsorption equipments for batch and continuous

operations (co current and counter current) adsorption in fixed beds

Unit- VI

Chromatography

Principles of chromatographic separation ndash gel filtration reversed phase hydrophobic interaction

ion-exchange expanded bed adsorption bio affinity and IMAC supercritical fluid chromatography

Text books

1 Belter PA Cussler E and Wei Shan Hu Bioseparation ndash Downstream Processing for

Biotechnology Wiley Interscience 1988

2 Asenjo and Juan A Asenjo Separation Processes in Biotechnology CRC Press 1990

3 Wankat PC Rate Controlled Separation Kluwer Publishers 1990

4 Wang DIC Cooney CL Demain AL DunnilP Humphery AE and Lilly MD Fermentation

and Enzyme Technology John Wiley and Sons 1979

BT-721 2 Elective - Industrial Waste water treatment

UNIT I

Waste disposal management Methods of waste disposal industrial waste (solid liquid and gaseous

emission) effect of industrial wastes on streams and sewerage systems Treatment system of waste

disposal eg Incenerator differences in waste quality and quantity physico-chemical and biological

treatments of waste and their evaluation in respect of treatment

UNIT II

Characteristic features of wastes (solid liquid and gaseous emission) manufacturing processes and

toxic byproducts generated from iron ore alumina heavy metals units paper and pulp industries

pesticides industry thermal power station distillery textile and crude oil industry

UNIT III

Small and large scale industries for waste reduction and remediation various methods for waste

alteration volume and strength minimization recycling plants material restoration and conservation

Methods for neutralisation equalization precipitation and solidification for waste handling

Economic sustainability and government support for joint treatment of raw effluent municipal

sewage and debris

UNIT IV

Unit operations and their design for treatment and management of wastes (solid liquid and gaseous)

UNIT V

Landfill design and operation including site selection engineered sites liners and covers leachate

control and treatment gas recovery and control including utilization of recovered gas (energy) and

landfill monitoring and reclamation

UNIT VI

Case studies

Text Books

1 S P Mahajan ldquoPollution Control in Process Industriesrdquo Tata Mc Graw Hill Publications

2 W Wesley Eckenfelder Jrrdquo Industrial Water Pollution Controlrdquo Mc Graw Hill Publications

3 Ronald W Crites Sherwood C Reed and Robert Bastion ldquoLand Treatment Systems for Municipal

amp Industrial Wastesrdquo Mc Graw Hill Publications

4 Neal K Ostler ldquoIndustrial Waste Stream Generationrdquo Prentice Hall

5 Rao and Dutta ldquoIndustrial waste treatmentrdquo Oxford and IBH Publishing Co Pvt Ltd New Delhi

6 Dr A D Patwardhan ldquoindustrial Waste Water Treatmentrdquo Prentice Hall of India

BT-721 3 Elective-Biopolymer Technology Unit-I

Introduction

Biopolymers ndash The current scenario different biopolymers ndash produced from various renewable

resources characteristics merits and demerits over conventional polymers

Unit-II

Biopolymer Technology and Applications

Biopolymers and Artificial Biopolymers in Biomedical Applications an Overview Novel Synthesis

of Biopolymers and Their Medical Applications Composite Films Based on Poly (Vinylalcohol) and

Lignocellulosic Fibres Preparation and Characterizations Composite Materials Based on Gelatin

and Fillers from Renewable Resources Thermal and Mechanical Properties Properties of PHAs and

Their Correlation to Fermentation Conditions

Unit-III

Biosynthesis and Modifications

Synthesis and modification of different Biopolymers like xanthum gum

Unit-IV

Biosurfactants

Source characteristics and properties of Biosurfactants Production of Biosurfactants via the

fermentation and biotransformation routes Production of Biosurfactants with immobilized cells

Integrated bioprocess for continuous production of Biosurfactants including downstream processing

Applications of Biosurfactants-Food Industry Environmental Control

Unit-V

Bioplastic

Different types of bioplastics Starch-based plastic Cellulose-based plastic Aliphatic polyesters

Poly-3-hydroxybutyrate (PHB) Polylactic acid (PLA) Polyamide Bio-derived polyethylene

Advantages of bioplastic over petroleum-based polymer Mechanism of synthesis of Poly (-

hydroxybutyric acid) (PHB)

Unit-VI

Material Testing and Analytical Methods

An Overview of Available Testing Methods Comparison of Test Systems for the Examination of the

Fermentability of Biodegradable Materials Structure- Biodegradability Relationship of biopolymers

Text Books

1 Emo Chiellini Emo Chiellini and Helena Gil Biorelated Polymers Sustainable Polymer Science

and Technology Springer 2001

2 Johnson RM LY Mwaikambo and N Tucker Biopolymers Rapra Technology 2003

3 Naim Kosaric (Ed) Biosurfactants Marcell Dekker Inc 1993

BT-721 4 Elective ndash Bioprocess Plant Designing Unit-I

Process development

Introduction to Design ndash nature of design ndash Technical feasibility survey Mass and energy balance

process development ndash data acquisition ndash design data information of project - Organization of project

ndash Project documentation ndash codes and standards

Unit-II

Design Development

Equipment selection and specifications-materials of construction ndash flow sheeting - piping and

instrumentation ndash process safety and loss prevention

Unit-III

General site consideration

Introduction ndash plant location and site selection ndash site layout- plant layout utilities ndash environmental

considerationsndash waste management ndash visual impact ndash government regulations and other legal

restrictions community factors and other factors affecting investment and production costs ndash human

resources

Unit ndashIV

Selection and specification

Selection and specification of equipment for handling fluids and solids Selection specification

design of heat and mass transfer equipment used in bioprocess industries Design of facilities for

cleaning of process equipment used in biochemical industries Utilities for biotechnology

Unit-V

Design of fermenters

Design of fermentation Design considerations for maintaining sterility of processing equipment

Unit-VI

Process economics

Production plants Bioprocess validation Safety considerations

Text books

1 Applied Process Design for Chemical and Petrochemical Plants by EE Ludwig Publisher

Butterworth-Heinemann

2 Chemical Engineering by RK Sinnott JM Coulson and JF Richardsons Publisher

Butterworth-Heinemann Vol-6 Butterworth Heinemann III editionndash 2002

3 Peters and Timmerhaus Plant Design and Economics for Chemical Engineers Mcgraw Hill

4thEdition 1989

4 Rudd and Watson Strategy of Process Engineering Wiley 1987

BT-721 5 Elective- Transport Phenomenon Unit -I

Diffusion

Molecular and turbulent diffusion Diffusion coefficient Flickrsquos Law of diffusion Dependence of

diffusion coefficient on temperature pressure and composition Diffusion in multi-component gas

mixtures Diffusion in solids Molecular Knudsen ampsurface diffusion Inter- phase mass transfer

Mass transfer coefficients Diffusion between phases Equilibrium solubility of gases in liquids

Mass Transfer theories Mass transfer in fluidized beds flow past solids and boundary layers

Simultaneous heat and mass transfer Mixing in a Bioreactor -Flow regimes with and without baffles

various types of impellers and mixing equipment Power Requirements for Mixing Ungassed

Newtonian Fluids Gassed Fluids Improving Mixing in Fermenters Effect of Rheological Properties

on Mixing Role of Shear in Stirred Fermenters

Unit-II

Drying and Crystallization

Solid-gas equilibria Different modes of drying operation Types of batch and continuous dryer

Definitions of moisture contents Rate of batch drying Time of drying Mechanism of batch drying

Continuous drying Equilibrium yield of crystallization Heat and mass transfer rates in

crystallization Theories of crystallization Factors governing nucleation and crystal growth rates

controlled growth of crystal Classification of crystallizers

Unit ndashIII

Absorption and Adsorption

Gas-Liquid equilibriaHenryrsquos Law Selection of solvents Absorption in tray column Graphical and

analytical methods Absorption in packed column Design equation for packed column HTU NTU

and HTEP concepts Equipments Description of adsorption process and their application Types of

adsorption Nature of adsorbents Adsorption equilibrium and adsorption hysterises Stage wise and

continuous contact adsorption operation operations Determination of number of stages Equipments

Unit-IV

Momentum transfer

Review of basic concepts ndash Conservation of Mass Conservation of Energy Momentum Balance ndash

Momentum Balance in a Circular Pipe Flow Velocity Profile Fermentation Broth Rheology ndash

Viscosity Rheological Properties of Fermentation Broths Factors affecting broth viscosity

Unit V

Conduction and Convection

Introduction Conduction Basic concepts of conduction in solids liquids and gases One and two

dimensional heat conduction Critical and optimum insulation thickness Introduction to unsteady

state heat transfer Principles of convection Equations of forced and free convection

Unit ndashVI

Radiation

Basic laws of heat transfer by radiation black body and gray body concepts solar radiations

combined heat transfer coefficients by convection and radiation Introduction of Heat Transfer

Equipments Heat Exchangers Evaporators Condenser

Text Books

1 Holman JP ldquoHeat Transferrdquo 9 th ed McGraw Hill (1989)

2 Treybal R ldquoMass Transfer Operationsrdquo 3rd ed New York McGraw-Hill (1980)

3 McCabe Smith Unit Operations in Chemical Engineering McGraw Hill

4 Foust A S etal ldquoPrinciples of Unit Operationsrdquo John Wiley (1980)

5 R B Bird et al Transport Phenomena 2nd Edition Wiley(2006)

BT-721 6 Elective ndash Biochemical thermodynamics Unit-I

Fundamental concepts of Thermodynamics

System and Surroundings First law of thermodynamics -Internal energy enthalpy Heat capacity

applied examples from biochemistry Second law ndash Entropy and universe Concept of heat engines

protein stability and calorimetric measurements Fundamentals of Differential scanning calorimeter

and Isothermal calorimeter in biological property measurements Third law of thermodynamics

Maxwell equations Gibbs-Duhem Equation and the Phase Rule Legendre Transforms

Unit-II

Non-equilibrium Thermodynamics

Reversible work exact differentials and function of state first and second law The electrochemical

potential External forces and steady state Fickrsquos Law chemical reactions in the steady state internal

entropy production cells as non-equilibrium stationary states Diffusion and membrane transport

Biological Systems as Open Non-equilibrium Systems Failure of classical thermodynamics in

describing biological processes Standard free energy changes and equilibrium constants direction

and rate

Unit-III

Bioenergetics

Energetics of metabolic pathways ndash energy coupling (ATP amp NADH) stoichiometry ndashenergetic

analysis of cell growth and product formation ndash elemental balances Degree ofreduction concepts

available- electron balances yield coefficients oxygen consumptionand heat evolution in aerobic

cultures thermodynamic efficiency of growth Thermodynamics of Biological Systems

Thermodynamic analysis of oxidative photophosphorylation stability of non-equilibrium stationary

states ordering in time and space far from equilibrium glycolytic oscillations Biological clocks

routes to chaos

Unit-IV

Chemical Potential

Visualization of the potential Steady velocity and steady flow Fickrsquos law and diffusion Local

Equilibria and Steady State Energy vs Power Transducers in biological states Constitutive

equations Dynamic efficiency and Onsager (nonequilibrium thermodynamics) Prigoginersquos principle

Spontaneous coupling and entropy production

Unit-V

Gibbs free energy and its Applications

Gibbs free energy and equilibrium Chemical potential ionic solutions Equilibrium constant

standard state in biochemistry Acid and bases chemical coupling and redox reactions Gibbs free

energy in photosynthesis glycolysis citric acid cycle Oxidative phosphorylation and ATP

hydrolysis substrate cycling Membrane transport Enzyme substrate interaction Haemoglobin

Protien solubility stability and dynamics

Unit-VI

Reaction Kinetics

Rate of a reaction rate constant and order of the reaction effect of temperature collision and

transition state theory Electron transfer kinetics Enzyme kinetics and inhibition Reaction

mechanism of lysozyme protein folding and pathological misfolding polymerisation muscle

contraction and the molecular motors

Text Books

1 Smith JM Van Ness HC Abbot MM Chemical Engineering Thermodynamics 6th Edition

McGraw-Hill 2001

2 Narayanan KV A Text Book Of Chemical Engineering Thermodynamics Prentice Hall India

2001

3 Sandler SI Chemical And Engineering Thermodynamics John Wiley1989

4 Bailey amp Ollis Biochemical Engineering Fundamentals II edition Megraw Hil ndash 1986

5 Donald T Haynie Biological Thermodynamics Cambridge press 2008

6 Robert A Alberty Thermodynamics of Biochemical Reactions John willy publications 2003

7 Bioenergetics by AL Lehninger Publisher WA Benjamin Inc

8 Biological Thermodynamics by DT Haynie Publisher Cambridge University Press

9 Biophysical Chemistry by CR Cantor and PR Schimmel Publisher

10 FreemanThermodynamics and Kinetics for the Biological Sciences by GG Hammes Publisher

John Wiley and Sons Inc

BT-7221 Elective - Bioethics Biosafety and IPR Unit I

Introduction to ethics and bioethics

Personal ethics profession and professionalism -Moral Reasoning -Ethical theories - person as an

experimenter -Moral leadership (integrity and ingenuinity) ndash framework for ethical decision making

Biotechnology and ethics Biotechnology in agriculture and environment benefits and risks ndash

benefits and risks of genetic engineering ndash ethical aspects of genetic testing ndash ethical aspects relating

to use of genetic information ndash genetic engineering and biowarfare

Unit-II

Ethical implications of cloning

Reproductive cloning therapeutic cloning Ethical legal and socio-economic aspects of gene

therapy germ line somatic embryonic and adult stem cell research- GM crops and GMO‟s ndash

biotechnology and biopiracy ndash ELSI of human genome project

Unit-III

Introduction to biosafety

Biosafety issues in biotechnology ndash risk assessment and risk management ndash safety protocols risk

groups ndash biosafety levels ndash biosafety guidelines and regulations (National and International) ndash

operation of biosafety guidelines and regulations ndash types of biosafety containment International

guidelines with regard to rDNA technology transgenic science GM crops etc Experimental

protocol approvals levels of containment Guidelines for research in transgenic plants Good

manufacturing practice and Good lab practice (GMO and GLP)

Unit-IV

Introduction to intellectual property and intellectual property rights

Types patents copy rights trade marks design rights geographical indications ndash importance of IPR

ndash patentable and non patentables ndash patenting life ndash legal protection of biotechnological inventions ndash

world intellectual property rights organization (WIPO) Plant breederrsquos rights Legal implications

Biodiversity and farmers rights Examples of patents in biotechnology Special application of patent

laws in biotechnology Licensing and cross licensing Flavr SavrTm- Tomato as model case and case

studies

Unit-V

Public acceptance issues for biotechnology

Environmental aspects of biotech application Use of genetically modified organisms and their

release in environment Case studies or experiences from developing and developed countries

Biotechnology and hunger Challenges for the Indian Biotechnological research and industries

Unit-VI

Socioeconomic impacts of biotechnology

The legal and socioeconomic impacts of biotechnology public education of the processes of

biotechnology involved in generating new forms of life for informed decision making

Text Books

1 Ethics in engineering Martin MW and SchinzingerR III Edition Tata McGraw- Hill New

Delhi 2003

2 Biotechnologies and Development UNESCO Publications 1988

3 A Biotechnologies in developing countries present and future UNESCO Publishers 1993

4 Singh K Intellectual property rights on Biotechnology BCIL New Delhi

BT-722 4 Elective ndash Metabolic Engineering Unit ndash I

Cellular metabolism

An overview of cellular metabolism-transport processes- Fueling reactions -glycolysis-fermentative

pathways-TCA cycle and oxidative phosphorylation-anaplerotic pathways -catabolism of fats

organic acids and amino acids -biosynthetic reactions of amino acids ndash nucleic acids fatty acids and

other building blocks -polymerization - growth energetics

Unit ndash II

Comprehensive models for cellular reactions

Stoichiometry of cellular reactions -reaction rates-dynamic mass balances-Yield coefficients and

linear rate equation Material Balance and data consistency ndashblack box model elemental balance -

heat balance -analysis of over determined systems - identification of gross measurement errors

Unit ndash III

Regulation of metabolic pathways

Overview of enzyme kinetics ndash simple reversible inhibition systems ndash irreversible inhibition ndash

allosteric enzymes cooperativity ndash regulation of enzyme concentration ndash transcription initiation ndash

translation regulation at whole cell level ndash regulation of metabolic networks enhancements of

product yield and productivity for ethanol and amino acids pathways metabolic pathway

manipulations to extend substrate range product spectrum and novel products improvement of

cellular properties

Unit ndash IV

Metabolic flux analysis

Theory ndash overdetermined systems ndash underdetermined systems ndash sensitivity analysis ndash methods for the

experimental determination of metabolic fluxes by isotope labeling direct flux determination from

fractional enrichment ndash applications involving complete enumeration of metabolite isotopomers ndash

carbon metabolite balances Applications of metabolic flux analysis ndash amino acid production by

Glutamic acid Bacteria

Unit ndash V

Metabolic control analysis

Fundamentals of Metabolic control analysis -determination of flux control coefficients ndash MCA of

Linear pathways ndash branched pathways ndash theory of large deviation

Unit-VI

Applications of metabolic engineering

Text Books

1 Gregory N Stepanopoulos Aristos A Aristidou Jens Nielsen Metabolic Engineeing

2 Principles and methodologies Academic Press 1998

3 Wang DIC Cooney CL Demain AL DunnilP Humphery AE Lilly MD

4 ldquoFermentation And Enzyme Technologyrdquo John Wiley And Sons 1980

5 Zubay G ldquoBiochemistryrdquo Macmillan Publishers 1989

BT-722 3 Elective ndash Protein Engineering Unit-I

Bonds and Energies in protein

Covalent Ionic Hydrogen Coordinate hydrophobic and Vander walls interactions in protein

structure Interaction with electromagnetic radiation (radio micro infrared visible ultraviolet X-

ray) and elucidation of protein structure

Unit-II

Amino acids and their characteristics

Amino acids ndash structure with three and single letter codes- molecular properties (size solubility

charge pKa) Chemical reactivity in relation to post-translational modification (involving amino

carboxyl hydroxyl thiol imidazole groups) and peptide synthesis

Unit - III

Protein architecture

Primary structure peptide mapping peptide sequencing - automated Edman method amp massspec

High-throughput protein sequencing setup Secondary structure Alpha beta and loop structures and

methods to determine Super-secondary structure Aphaturn- alpha beta-turn-beta (hairpin) beta-

sheets alpha-beta-alpha topology diagrams up and down amp TIM barrel structures nucleotide

binding folds prediction of substrate binding sites Tertiary structure Domains folding denaturation

and renaturation overview of methods todetermine 3D structures Quaternary structure Modular

nature formation of complexes

Unit-IV

Structure-function relationship

DNA-binding proteins prokaryotic transcription factors Helix-turn-Helix motif in DNA binding

Trp repressor Eucaryotic transcription factors Zn fingers helix-turn helix motifs in homeodomain

Leucine zippers Membrane proteins and receptors bacteriorhodopsin and Photosynthetic reaction

center Immunoglobulins IgG Light chain and heavy chain architecture abzymes and Enzymes

Serine proteases understanding catalytic design by engineering trypsin chymotrypsin and elastase

substrate-assisted catalysis other commercial applications

Unit -V

Identification and analysis of proteins

Identification and analysis of proteins by 2D analysis Spot visualization and picking Tryptic

digestion of protein and peptide fingerprinting Mass spectrometry ion source (MALDI spray

sources) analyzer (ToF quadrupole quadrupole ion trap) and detector

Unit-VI

Tools in proteomics and genomics

Site directed mutagenesis for specific protein function Basic concept for designing a new

proteinenzyme molecule Specific examples of enzyme engineering Tryesyl t RNA synthetase

Dihydrofolate reductase Subtilisin Advantages ndash protein data base analysis ndash methods to alter

primary structure of proteins examples of engineered proteins thermal stability of T4-lysozyme

recombinant insulin to reduce aggregation and inactivation de novo protein design ndash principles and

examples

Text Books

1 Voet D and Voet G Biochemistry Third edn John Wiley and Sons 2001

2 Moody PCE and Wilkinson AJ Protein Engineering IRL Press Oxford UK 1990

3 Branden C and Tooze J Introduction to Protein Structured Second Edition GarlandPublishing

NY USA 1999

4 Creighton TE Proteins Freeman WH Second Edition 1993

BT-7222 Elective ndash Quality Management Unit-I

Quality Concepts

Definition of Quality Dimensions of Quality Quality Planning Quality costs ndash Analysis

Techniques for Quality Costs Evolution of Quality Control Basic concepts of Total Quality

Management Historical Review Leadership ndash Concepts Role of Senior Management Quality

Council Quality Statements Strategic Planning Deming Philosophy Barriers to TQM

Implementation Control on Purchased Product Procurement of various products evaluation of

supplies capacity verification Development of sources procurement procedure Manufacturing

Quality Methods and techniques for manufacture inspection and control of product quality in sales

and services guarantee analysis of claims

Unit-II

Quality Management

Organization structure and design quality function decentralization designing and fitting

organization for different type products and company economics of quality value and contribution

quality cost optimizing quality cost seduction program Human Factor in quality Attitude of top

management cooperation of groups operators attitude responsibility causes of apparatus error and

corrective methods

Unit-III

Control Charts

Theory of control charts measurement range construction and analysis of R charts process

capability study use of control charts

Attributes of Control Chart

Defects construction and analysis of charts improvement by control chart variable sample size

construction and analysis of C charts

Unit -IV

Defects diagnosis and prevention defect study identification and analysis of defects correcting

measure factors affecting reliability MTTF calculation of reliability building reliability in the

product evaluation of reliability interpretation of test results reliability control maintainability zero

defects quality circle

Unit-V

Statistical process control

The seven tools of quality Statistical Fundamentals ndash Measures of central Tendency and Dispersion

Population and Sample Normal Curve Control Charts for variables and attributes Process

capability Concept of six sigma New seven Management tools

Unit-VI

Quality system

Need for ISO 9000 and Other Quality Systems ISO 90002000 Quality System ndash Elements

Implementation of Quality System Documentation Quality Auditing QS 9000 ISO 14000 ndash

Concept Requirements and Benefits

Text Books

1 Lt Gen H Lal ldquoTotal Quality Managementrdquo Eastern Limited 1990

2 Greg Bounds ldquoBeyond Total Quality Managementrdquo McGraw Hill 1994

3 Menon HG ldquoTQM in New Product manufacturingrdquo McGraw Hill 1992

4 Dale HBesterfiled et at Total Quality Management Pearson Education Asia 1999

5 James REvans amp William MLidsay The Management and Control of Quality (5thEdition)

South-Western (Thomson Learning) 2002 (ISBN 0- 324-06680-5)

6 FeigenbaumAV ldquoTotal Quality Management McGraw-Hill 1991

7 OaklandJS ldquoTotal Quality Management Butterworth ndash Hcinemann Ltd Oxford 1989

8 Narayana V and Sreenivasan NS Quality Management ndash Concepts and Tasks New Age

International 1996

9 Zeiri ldquoTotal Quality Management for Engineers Wood Head Publishers 1991

BT-722 5 ElectivendashDesign and Development of Biological Treatment process

Unit-I

Bacterial metabolism in wastewater treatment systems

Introduction decomposition of organic carbon compounds in natural and manmade systems aerobic

and anaerobic decomposition of glucose protein carbohydrates proteins lipids etc Nitrogen

removal during treatment enhanced biological phosphate removal biological removal bio-

transformations and biosorption of metal ions aerobic and anaerobic degradation of xenobiotics

Unit-II

Activated sludge process

Single and two stage process special developments technological and microbiological aspects plant

configurations design

Unit-III

Modeling of aerobic waste water treatment process

Introduction purpose of modeling activated sludge model presentations waste water characteristics

various disinfection methods for waste water

Unit-IV

High rate anaerobic waste water treatment

Introduction basic principles reactor design parameters reactor operation

Unit-V

Biological Nutrient removal

Suspended growth and attached growth nutrient removal processes and design criteria ndash Nitrogen

(Nitrification and denitrification) and Phosphorus precipitation biological) Biological removal of

toxic and recalcitrant organic wastes

Unit-VI

Water reuse

Wastewater reclamation risk assessment various reclamation technologies storage agricultural

reuse industrial reuse groundwater recharge

Text book

1 Joumlrdening HJ and JWinter Environmental Biotechnology - Concepts and Applications

Cambridge University Press 2006

2 George Tchobanoglous and Franlin L Burton Wastewater Engineering- Treatment Disposal and

Reuse Tata McGraw Hill Publishing Co Ltd 1990

BT-722 6 Elective ndash Bioinformatics

Unit I

Introduction to Biological Databases Types Overview of Biological Databases and Retrieve

Nucleic acid databases NCBI PubMed Entrez Blast OMIM Books Taxonomy Structure

Locuslink Protein Databases- Primary Functional Composite Secondary Structural classification

database Sequence Formats amp storage Sequence submission to sequence Database

Unit II

Genomics Structure of DNA Polymorphisms in DNA Sequence Human Genome Project

Complete Genome Sequences Functional Annotation

Unit III

Human Genetic Variation Databases and Concepts Introduction Forms and mechanisms of

genetic variation Databases of human genetic variation SNP databases Mutation databases Genetic

marker and microsatellite databases Nonnuclear and somatic mutation databases Tools for SNP and

mutation visualization

Unit IV

Biological Sequence Analysis amp Characterization Predictive Functional Analysis of coding and

non-polymorphisms Amino Acid Properties and Consequences of Substitutions

Unit V

Genetics Genomics Interfaces Technologies for the measurement of gene expression The Cancer

Genome Anatomy Project (CGAP) The Human Transcriptome Map Protein Interaction Networks

Computational methods for pathways and systems biology databases and web resources

Unit VI

Soft computation Neural Networks and Machine learning support vector machines fuzzy logic

evolutionary computing genetic algorithms- applications to data mining and bioinformatics

Text Books

1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves Noah Hardy

ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd

2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS ISBN978-81-8318minus831minus9

Himalaya Publication House Discovering Genomics Proteomics and Bioinformatics Campbell

ISBN978813171 5598 Pearson Education

3 Proteomics Theory and Practice Gomase VS and Chikhale NJ Himalaya Publication House

4 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978- 3-527-30541-4

John Wiley amp Sons India Pte Ltd

5 Introduction to Bioinformatics Arthur M Lesk Oxford University Press 2003

6 Sequence and Genome Analysis by David W Mount - Cold Spring Harbor Laboratory 1st edition

2004

7 Bioinformatics A Practical Guide to the Analysis of Genes and Proteins by Andreas D

Baxevanis B F Francis Ouellette Wiley-Interscience 3rd Edition 2004

8 Sequence structure and Database ndash Des Higgins Willice Taylor Oxford press 1st edition (2003)

9 Fundamental Concepts of Bioinformatics - Dan E Krane Michael L Raymer Pearson education

First edition (2004)

BT-723 Self Study Open Area Seminar-II

BT-724 Minor Project- II

BT-725 Major Project- I

SEMESTER IV

BT-821 Major Project- II

Scheme of Examination and Syllabus

MTech in Industrial Biotechnology

Department of Biotechnology Delhi Technological University

Bawana Road New Delhi -110042

MTech in Industrial Biotechnology Biotechnology Industry Organization (BIO) USA has mentioned three major waves in the field of

biotechnology The first wave Green Biotechnology refers to agricultural biotechnology The

second wave Red Biotechnology refers to pharmaceutical and medical biotechnology while the third

wave White Biotechnology refers to industrial biotechnology Industrial biotechnology is mainly

based on biocatalysis (the use of enzymes and cells to catalyse chemical reactions) and fermentation

technology (directed use of micro-organisms) in combination with recent breakthroughs in the

forefront of molecular genetics and metabolic engineering It includes manufacturing of antibiotics

(cephalosporins streptomycin penicillin) food (yoghurt cheese single cell protein mushroom

probiotics) renewable energy (bioethanol biodiesel biohydrogen) health care (growth hormone

antibodies) biopolymers (polyhydroxy butyrate polylactic acid) enzymes (protease lipase amylase

cellulase pectinase xylanase) in various industries (pulp and paper detergent textile food

processing industry) Industrial biotechnology also involved in bioremediation microbial

degradation of pollutants (hydrocarbons polychlorinated biphenyl polyaromatic hydrocarbons)

Biological waste water treatment is undoubtedly one of the most important biotechnological

processes which have been used to treat municipal waste and industrial waste water The proposed

syllabus has been developed to address the need of well trained industrial biotechnologist cutting

edge RampD for this field The trained manpower will be well versed in techniques of protein science

bio-catalysis engineering biosynthesis microbial manufacturing engineering biological systems and

bio-process engineering Moreover they can easily implement these hands on training in industry to

increase the yield more accurately

Delhi Technological University Delhi

Department of Biotechnology

Scheme of Examination

MTech in Industrial Biotechnology

First semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-521 Bioenergy 3 1 0 50 100 150 3

BT-522 Food Engineering

amp Biotechnology

3 1 0 50 100 150 3

BT-523 Enzyme

Engineering amp

technology

3 1 0 50 100 150 3

BT-571 Industrial Plant

Biotechnology

3 1 0 50 100 150 3

BT-572 Bioinstrumentation 3 1 0 50 100 150 3

BT-573 Food engineering

and Biotechnology

Lab

0 0 2 30 70 100 2

BT-524 Bioinstrumentation

Lab

0 0 2 30 70 100 2

BT-574 Self Study open

area seminar-I

0 0 1 50 - 50 1

TOTAL 360 640 1000 20

Second semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-621 Biopharmaceuticals 3 1 0 50 100 150 3

BT-6221 Bioprocess

Engineering

3 1 0 50 100 150 3

BT-6231 Biosensor 3 1 0 50 100 150 3

BT-6711 Nanobiotechnology 3 1 0 50 100 150 3

BT-6721 Environmental

Biotechnology

3 1 0 50 100 150 3

BT-673 Environmental

Biotechnology Lab

0 0 2 30 70 100 2

BT-624 Bioprocess

Engineering Lab

0 0 2 30 70 100 2

BT-674 Minor Project-I 0 0 1 50 - 50 1

TOTAL 360 640 1000 20

Third semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-721 Professional

Elective I

3 1 0 50 100 150 3

BT-722 Professional

Elective II

3 1 0 50 100 150 3

BT-723 Self Study open

area seminar-II

0 0 1 100 100 2

BT-724 Minor Project-II 300 300 6

BT-725 Major Project-I 300 300 6

TOTAL 200 800 1000 20

Fourth semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-821 Major Project-II 400 600 1000 20

TOTAL 1000 20

BT- 721 ELECTIVE SUBJECTS- I

BT-7211 Bioseparation Technology

BT-7212 Industrial waste water treatment

BT-7213 Biopolymer Technology

BT-7214 Bioprocess Plant Designing

BT-7215 Transport Phenomenon

BT-7216 Biochemical Thermodynamics

BT-722 ELECTIVE SUBJECTS- II

BT-7221 Bioethics Biosafety and IPR

BT-7222 Quality Management

BT-7223 Protein Engineering

BT-722 4 Metabolic Engineering

BT-7225 Design and Development of Biological Treatment process

BT-7226 Bioinformatics

SEMESTER I

BT- 521 Bioenergy

Unit-I

Introduction

Global energy scenario Indian energy scenario types of energy sources description of Biofuels

various Biofuels Bioenergy from biomass Biofuel Production Alternative Biochemical Pathways for

Organo-heterotrophic Lithotrophic and Phototrophic Metabolism Importance of biofuel feed stocks

Cellulose starch sugar Lignocellulosic Agro and Industrial by-products

Unit-II

Production of Bio-ethanol

Process Technology for Bioethanol production using Sugar Starch and Lignocellulosic Selection of

micro-organisms and raw materials Unit Operations in Alcohol production Continuous

fermentation Distillery quality control Alcohol distillation

Unit-III

Production of Biodiesel

Chemical Thermodynamic and Reaction Kinetic Aspects of Biodiesel Production Lipids as a source

of biodiesel Methods of Biodiesel Production ndash General procedure and large scale production

Quality Control Aspects Biodiesel production from microalgae and future prospects

Unit-IV

Production of Biohydrogen

Biohydrogen production by anaerobic bacteria and photosynthetic algae Enzymes involved in

biohydrogen Production Biochemical Pathway Batch Fermentation Factors affecting biohydrogen

production Carbon sources Process and Culture Parameters Detection and Quantification of

biohydrogen

Unit-V

Microbial Fuel Cells

Introduction and biochemical basis History of microbial fuel cell development Microbes used in

microbial fuel cells Design of microbial fuel cells MFC components Two and Single MFC systems

Stacked microbial fuel cell Performances of microbial fuel cells Ideal performance Actual MFC

performance Effects of operating conditions pH buffer and electrolyte Proton exchange system

Operating conditions in the anodic chamber Operating conditions in the cathodic chamber

Applications Electricity generation Biohydrogen Wastewater treatment Biosensor MFCs in the

future

Unit-VI

Case studies

Text books

1 Caye M Drapcho NP Nhuan and T H Walker Biofuels Engineering Process Technology Mc

Graw Hill Publishers New York 2008

2 Jonathan RM Biofuels ndash Methods and Protocols (Methods in Molecular Biology Series) Humana

Press New York 2009

3 Lisbeth Olsson (Ed) Biofuels (Advances in Biochemical EngineeringBiotechnology Series

Springer-Verlag Publishers Berlin 2007

BT- 522 Food Engineering and Biotechnology

Unit- I

Food chemistry

Food chemistry-definition and importance Composition of foods and function of water

carbohydrates proteins amino acids lipids vitamins and shelf life of food Bioavailability and

stability of nutrients Nutritive value of foods Food as a source of energy Food Health and diseases

Unit ndash II

Food Microbiology

History and significance of microorganisms in foods Biotechnological improvements catabolic

repression Microbial growth pattern Biochemical changes caused by micro-organisms deterioration

of various types of food product Food poisoning and microbial toxins standards for different foods

Food borne intcericants and mycotoxius

Unit ndashIII

Fermentation products

Dairy products Production of starter cultures Cheese - principles of cheese making Cheddar

Cheese Swiss Cheese Surface ripened Cheeses Mold ripened Cheeses General principles of

manufacture of Kefir Fermented foods Soy sauce Miso Sufu Natto Idli fermented fish products

Fermented vegetables Sauer Krant pickles Olives Fermented sausages Distilled beverages

Alcohol wine brandy and beer Food additives organic acid (acetic acid lactic acid and citric acid)

amino acids (glutamic acid lysine threonine arginine and histidine) food flavourants and pigments

Unit ndashIV

Food Preservation and storage

General principles underlying spoilage and chemical changes of food caused by microorganisms

(Staphylococcal Salmonellosis Ecoli) food spoiling enzymes Botulism toxin production and

deterioration of foods Principles of food preservation by physical methods (irradiation drying heat

processing chilling and freezing high pressure and modification of atmosphere) by chemical

methods and biological methods Storage Stability Food Preservation with Low Temperatures Food

Preservation with High Temperatures Preservation of Foods by Drying Indicator and Food-borne

Pathogens

Unit V

Food process technology

Packaging and canning of foods ndash preparation for packaging thermal processing of foods

Microwave heating thermal inactivation of microorganisms thermal process evaluations freezing

and thawing of foods Food process operations Evaporation single and multi effect evaporation

dehydration psychomatric charts drying-tunnel tray spray drum freeze distillation food

processing aid through biotechnology Food sanitation Good manufacturing practices ndash Hazard

analysis Critical control points Personnel hygiene

Unit ndashVI

Food Processing and Quality assurance

Basic principles unit operations and equipment involved in the commercially important food

processing methods and unit operations materials and containers used in food packaging Objectives

importance and functions of quality control Methods of quality assessment of food materials-fruits

vegetables cereals dairy products meat and poultry Food regulations grades and standards

Concept of Codex AlmentariousHACCPUSFDAISO 9000 series etc Food laws and standards

Text Books

1 Frazier WS and Weshoff DC Food Microbiology 4th Edn McGraw Hill Book Co New

York 1998

2 Mann amp Trusswell Essentials of human nutrition 3rd edition oxford university press 2007

3 Prescott and Dunns Gerald Reed Industrial Microbiology 4th Edition AVI Publishing Company

Inc Conneticut 1983

4 BSivashankar ndash Food processing and preservation Prentice ndash Hall of India PvtLtdNew Delhi

2002

BT- 523 Enzyme Engineering and Technology

Unit-I

Introduction to enzymes

Introduction nomenclature and classification of enzyme Mechanism and catalysis concept of active

site and energetics of enzyme substrate complex formation specificity of enzyme action principles

of catalysis ndash collision theory transition state theory role of entropy in catalysis Biocatalysis in

organic liquids Enzymatic catalysis in biphasic system Ribozyme Abzyme (catalytic antibodies)

Biosynthesis and regulation of enzyme in microorganism

Unit-II

Enzyme Kinetics

Kinetics of substrate and multisubstrate reactions King-Altmanrsquos method Analysis of kinetic data

Inhibition - substrate product and inhibitors Active and legend binding sites Allosteric regulation of

enzymes Monod changeux wyman model deactivation kinetics Molecular folding and defolding of

enzymes

Unit - III

Enzyme immobilization

Methods of immobilization External and internal diffusional mass transfer limitation Effectiveness

factor and modulus electrostatic and stearic effects in immobilized enzyme systems

Unit-IV

Enzyme Reactor

Reactors for Batch continuous enzymatic processing choice of reactor type idealized enzyme

reactor systems Mass transfer in enzyme reactors Steady state analysis of mass transfer and

biochemical reaction in enzyme reactors

Unit ndashV

Purification and Characterization of enzymes from natural source

Production and purification of crude enzyme extracts from plant animal and microbial sources

methods of characterization of enzymes

Unit-VI

Application of enzymes

Application of enzymes in different industries (Pulp and Paper industry Detergent industry Textile

industry Food processing industry) Medical and analytical application of enzyme Biosensor

Text books

1 Enzymes A Practical Introduction to Structure Mechanism and Data Analysis by RA Copeland

Publisher John Wiley and Sons Inc

2 Enzymes by Palmer (2001) Horwood Publishing Series

3 Introduction to Biocatalysis using Enzymes and Microorganisms by SM Roberts NJ Turner and

A J Willetts Publisher Cambridge University Press

4 Fundamentals of Enzymology by Price and Stevens (2002) Publisher Oxford University Press

5 Enzyme Technology by Helmut Uhling (1998) Publisher John Wiley

6 Introduction to Proteins Structure by Branden and Tooze (1998) Publisher Garland Publishing

7 Enzyme Kinetics Behavior and Analysis of Rapid Equilibrium and Steady - State Enzyme

Systems by IH Segel Publisher Wiley-Interscience

BT-571 Industrial Plant Biotechnology

Unit-I

Plant genome organization

Organization and features of mitochondrial nuclear and choloroplast genome ndash Structural features of

gene families in plants

Unit-II

Plant cell cultivation

Callus cultures cell cultures and protoplast cultures Micropropagation Organogenesis and somatic

embryogenesis Cell suspension culture Ovule culture Anther culture Production of haploids

Protoplast isolation and fusion Selection systems for somatic hybridscybrids Somaclonal variation

Preservation of germplasm Formation of Secondary Metabolites in Tissue Culture Production of

pharmaceuticals by tissue culture pigments perfumes flavors insecticides flavonoids

Biotransformation using plant cell cultures Bioreactor system and models for mass cultivation of

plant cells hairy root culture Quality assurance and quality control

Unit-III

Transgenic plant and application

Transgenesis in plants Gene transfer in plants ndash Gene transfer through vectors - Biology of vectors

used - Ti and Ri plasmids binary vectors viral vectors cloning strategy and method of gene transfer

Vectorless gene transfer ndash electroporation and gene gun method DNA bar coding Application of

transgenic plants Virus resistance coat protein mediated nucleocapsid gene Nematode resistance

Abiotic stress Drought cold and salt Post-harvest losses long shelf life of fruits and flowers use of

ACC synthase polygalacturanase ACC oxidase male sterile lines bar and barnase systems

carbohydrate composition and storage ADP glucose pyrophosphatase RNAi and Reverse genetics

Unit- IV

Natural Resource Management

Different approaches of Biodiversity Conservation Biotechnological Characterization and strategies

for the conservation of different populations of endangered plants Molecular markers and genetic

diversity screening

Unit-V

Plant metabolism Metabolomics and metabolic engineering

General concepts of metabolism Introduction to databases from plant transcriptomics to

metabolomics

Unit VI

Industrial applications

Industries engaged in tissue cultureplant cell suspension culture their working and management

Pharmaseutically useful metabolites generated by suspension cultures

Text books

1 Dixon RA and Gonzales Plant Cell Culture A Practical Approach IRL Press 1995

2 Lindsey K and MGK Jones Plant Biotechnology in Agriculture Prentice Hall New Jersey

1990

3 Biotol series In vitro Cultivation of Plant cell Butterworth Heinemann Ltd 1994

4 Ranga MM Animal Biotechnology (3e) Agrobios 2007

5 Bhojwani amp Rajdhan Animal and Plant Biotechnology Elsevier 1996 )

6 Gene cloning amp DNA Analysis An introduction by T A Brown Fourth edition (2001)

7 Genetic Engineering by S Rastogi and N Pathak Publishers Oxford University Press(2009)

8 Principles of Gene Manipulation amp Genomics by Primrose amp Twyman Seven edition (2006)

BT- 572 Bioinstrumentation

Unit I

Electrochemistry Temperature pH buffers Conductivity Dissolved oxygen carbon dioxide

Unit II

Centrifugation Basic principle and application Analytical and Preparative centrifuges and ultra

centrifugation

Unit III

Electrophoretic Techniques Paper and gel electrophoresis Immuno electrophoresis isoelectric

focussing two-dimensional electrophoresis capillary electrophoresis

Unit IV

Chromatographic Methods Paper TLC gas chromatography gel filtration ion exchange

chromatography affinity chromatography and HPLC FPLC

Unit V

Spectroscopy UVvisible and NIR spectrofluorimetry Atomic absorption spectrophotometryMass

Spectrometry Infrared and Raman SpectroscopyNuclear Magnetic Resonance and Electron Spin

Resonance spectroscopy

Unit VI

Microscopy Principle parts types and functioning of Microscope Optical and Electron

Microscopy Transmission and Scanning Electron Microscopy Tunneling Electron Microscopy

Atomic Force Microscopy Fluorescence microscopy Confocal microscopy

Text books

1 Principles and Techniques of Practical Biochemistry by Keith Wilson and JohnWalker Cambridge

University Press

2 Biophysical Chemistry The conformation of Biological Macromolecules by CRCantor and PR

Schimmel Publisher WH Freeman

Reference books

1 Essentials of Biophysics by P Narayanan Publishers New Age InternationalPublishers

2 Introduction to Spectroscopy by DL Pavia GM Lampman and G S Kriz Publisher Brooks

Cole

3 Physical Chemistry of Macromolecules by C Tanford Publisher John Wileyand Sons Inc

4 Principles of Physical Biochemistry by KE Van Holde Publisher Prentice Hall

BT-524 Lab- Bioinstrumentation 1 Measurement and control of pH 2 Measurement of conductivity of a given sample

3 Measurement of conductivity and dissolved oxygen in given sample

4 Protein quantification

5 Protein separation through electrophoresis

6 Sample preparation for light microscopy and Electron Microscopy

7 Quantification of DNA RNA Lipid Fatty acids

8 Sample analysis through AAS

9 Sample preparation for Fluorescence and Confocal microscopy

10 Isolation of DNA and analysis by gel electrophoresis

BT-573 Lab- Food Engineering and Biotechnology

1 Isolation of industrially important microbes

2 Production of fermented product

3 Comparative studies of ethanol production using different substrates

4 Production of wine

5 Production of citric acid

6 Detection of adulterants in food

7 Mushroom cultivation

8 Bread making

9 Colourant production

10 Studies of different methods of food preservation

11 Estimation of carbohydrates and proteins

BT-574 Self Study Open Area Seminar-I

SEMESTER II BT- 621 Biopharmaceuticals

Unit-I

Drug metabolism Oxidation reduction hydrolysis conjugation Need for developing new drugs

Procedure followed in drug design Molecular modification of lead compounds Prodrug and soft

drugs Physico-chemical parameters in drug design QSAR Active site determination of enzymes

Design of enzyme inhibitors

Unit-II

Pharmacokinetics and Drug discovery

Biotransformation of drugs Preclinical Pharmacokinetics Compartment modelingone compartment

open model two compartment open model multi compartment model non linear kinetics

bioavailability and bioequivalence excretion of drugs pharmacokinetics ndash effects of food and

fasting Substances derived from bacteria plants insects and animals Sources of active principles

Assay systems and models (eg Knock-out Mice) Protein molecular modeling by computer

Docking studies Structure based drug designing using software

Unit-III

Pharmaceutical dosage forms

Dosage Forms and Basic Preparations Excipients for Pharmaceutical Dosage Forms Compressed

tablets wet granulation dry granulation or slugging direct compression tablet formulation coating

capsules sustained action dosage form parental oral liquids ointments recombinant blood products

and therapeutic enzymes hormones of therapeutic interest Pharmaceutical products Analysis and

Control laxatives ndash analgesics ndash non steroidal contraceptives ndash external antiseptics ndash antacids and

other antibiotics ndash biological ndash hormones ndash vitamins - preservation analytical methods and test for

various drugs and pharmaceuticals packaging techniques ndash quality control

Unit-IV

Pharmaceutical products and products of DNA technology

Microbial products - Antibiotics (penicillin streptomycin tetracycline) vitamins probiotics Plant

secondary metabolites - control mechanism and manipulation of pheny-propanoid pathway and

shikimate pathway Tissue culture production of alkaloids flavanoids steroids terpenoids animal

vaccines Pharmaceutical products of DNA technology Therapeutic proteins ndash Insulin human

growth hormone clotting factors interferons interleukins tissue plasminogen activators

erythropoietin DNAseI alginate lyase muteins Production advantages limitations and applications

of monoclonal antibody Oligonucleotides and Gene therapy ras-Antisense therapy gene delivery

system Vector usage strategies for gene therapy Clinical trials

Unit-V

Drug safety evaluation

Strategy and Phasing for Drug Safety Evaluation in the Discovery and Development of

Pharmaceuticals Regulation of Human Pharmaceutical Safety Acute Toxicity Testing in Drug

Safety Evaluation Special Concerns for the Preclinical Evaluation of Biotechnology Products

Immunotoxicology in Pharmaceutical Development The Application of In Vitro Techniques in Drug

Safety Assessment Pharmaceutical Quality Assurance

Unit-VI

Patenting process in drug manufacturing process

Patenting- Patent types The patent application Patenting in biotechnology Preclinical trials Clinical

trials The role and remit of regulatory authorities-The Food and Drug Administration The

investigational new drug application The new drug application European regulations Guides to

good manufacturing practice Formulation and Delivery Issues of Therapeutic Proteins

Biotechnology-Derived Drug Products Formulation Development Stability Testing Filling and

Packaging

Text books

1 Heinrich Klefenz Industrial pharmaceutical biotechnology John Wiley sons 2002

2 Susanna Wu-Pong Yongyut Rojanasakul and Joseph Robinson Biopharmaceutical drug and

design and development Humana Press 2007

3 Gary Walsh Biopharmaceuticals Biochemistry and Biotechnology (2e) John Wiley amp Sons

2003

4 Herbert A Kirst Wu-Kuang Yeh Milton J Enzyme Technologies for pharmaceutical and

biotechnological applications WILEY-VCH Verlag 2003

BT- 6221 Bioprocess Engineering

Unit I

Media design and Sterilization kinetics

Criteria for good medium medium requirements for fermentation processes carbon nitrogen

minerals vitamins and other complex nutrients oxygen requirements medium formulation of

optimal growth and product formation examples of simple and complex media medium

optimization methods ndash Plackett and Burman and Response surface method Thermal death kinetics

of microorganisms batch and continuous heat sterilization of liquid media design of sterilization

equipment-batch and continuous ilter sterilization of liquid media air sterilization

Unit II

Metabolic stoichiometry and energetics

Stoichiometry of cell growth and product formation elemental balances degrees of reduction of

substrate and biomass available electron balances yield coefficients of biomass and product

formation maintenance coefficients energetic analysis of microbial growth and product formation

oxygen consumption ndash steps involved in the transfer of oxygen to broth and heat evolution in aerobic

cultures

Unit III

Growth and Production kinetics

Kinetic models for microbial growth Monod model growth of filamentous organisms product

formation kinetics - leudeking-piret models substrate and product inhibition on cell growth and

product formation Production kinetics Design for single and multiple reaction size comparisons of

single reactor for single reactions multiple reactor systems for single reaction reactions in parallel

in series and seriesparallel reactions of first order Heterogeneous reactions kinetics and mechanism

of heterogeneous non catalytic and catalytic reactions Non ideal flow - residence time distribution

studies CE F and I curves RTD in ideal reactors Models for Non ideal flow ndash zero ndash parameter

model One parameter model and two parameter model

Unit IV

Types and design of bioreactor

Construction material Basic components ndash Agitator aerator valves and steam traps seals stirrer

glands Stirred tank batch bioreactor stirred batch bio reactor for enzymes cell cultures Continuous

Stirred Tank Bioreactor Continuous operation of mixed reactor enzyme reactions in a mixed

reactor substrate inhibition kinetics and product inhibition kinetics chemostat with cell cultures ndash

steady state cell and substrate concentrations and productivity as a function of dilution rate CSTR

with immobilized enzymes operation of CSTR in a constant feed rate policy-simulation for

conversions with and without diffusion limitations chemostat in series Graphical design Plug Flow

and Packed Bed Bioreactor Performance equation with Michelin-Menten kinetics substrate

inhibition and product inhibition plug flow reactor for immobilized enzymes operation of plug flow

reactor in constant feed rate policy simulation for conversion with and without diffusion limitations

Fedndashbatch reactor Applications of fed reactor Fed batch operation of mixed reactor material

balance on cell and substrate Recycle system Chemostat with recycle Biological waste water

treatment Feed forward control of the activated sludge process The Transient Behavior of

Bioreactors Stability analysis Stability of the chemostat Stability of chemostat with substrate

inhibition Operating diagram Transient responses of the chemostat control of the chemostat

Turbidostat operation Nutristat operation

Unit V

Instrumentation and Control

Biochemical process variables and their measurements Control principles and their application in

bioreactors Theory of electrode processes and their applications Measurement and control of pH

temperature dissolved oxygen aeration and agitation redox potential foam etc On-line analysis of

process parameters Introduction to biosensors Transduction principles used in biosensors

Characteristics of biosensors Biosensors based on amperometric potentiometric thermistor FET

fiber optics and bioluminescence Microbial biosensors Fundamentals of digital process control Use

of computer in control and optimization of microbiological processes

Unit VI

Downstream processing

Removal of microbial cells and solid matter foam separation precipitation filtration centrifugation

cell disruptions liquid-liquid extraction chromatography membrane process drying and

crystallization Quality analysis and product formulation - Product appearance product stabilization

shelf life analysis usage specific formulations quality analysis and control

Text books

1 Biochemical Engineering Fundamentals by JE Baily and DF Ollis Publisher McGraw Hill

(1986)

2 Biochemical Engineering by SAiba AE Humphry and NF Millis Publisher University of

Tokyo press(1973)

3 Bioreaction engineering principles by J Nielson and J Villadsen Publisher Plenum Press (1994)

4 Chemical Engineering Design Fourth edition by JM Coulson and JF Richardson Publisher

Butterworth Heinemann(2005)

5 Bioprocess Engineering- Kinetics Mass transport reactors and gene expression by WR Veith

Publisher John Wiley and Sons Inc(1994)

6Bioprocess Engineering Basic Concepts by ML Shuler and F Kargi Publisher Prentice Hall

(1987)

7Bioprocess engineering principles by P Doran Publisher- Academic press (1995)

BT-6231 Biosensor Unit-I

Introduction

A historical perspective Definition and Expanding Needs of Biosensors Advantages and limitations

Biosensor Economics various components of biosensors

Unit-II

Types of Biosensors

Biocatalysts based biosensors bio affinity based biosensors amp microorganisms based

biosensors biologically active material and analyte Types of membranes used in

biosensor constructions

Unit-III

Transducers in Biosensors

Various types of transducers principles and applications Bio- chemi- and lectrochemiluminescence

for fiber-optic biosensors Fluorescence-based fiber-optic biosensors

Unit-IV

Electrical Signal Detection in Biological Systems

Silicon glass and metal electrodes amplifier design Bioelectronic device production

microelectronic fabrication methods as adapted to bioelectronics hard and soft lithography bio-

compatibility of materials Existing types of Biosensors Miniaturisation and micro-systems

including sensing using optical techniques field effect transistors ion-selective and enzymatic

sensitive electrodes as well as impedance monitoring

Unit-V

Kinetic modeling for biosensors

The purpose and practice of modeling The flux equations The flux diagram for the membrane

enzyme electrode Deriving a complete kinetic model Kinetic modeling in other types of

biosensors- Potentiometric enzyme electrodes Optical and photometric biosensors Immunosensors

Unit-VI

Application and Uses of Biosensors

Biosensors in medicine and health care (For glucose monitoring and for DNA analysis Analysis of

the neural cell impulse signal and neural signal processing) biosensors for agriculture and food Low

cost- biosensor for industrial processes for online monitoring biosensors for environmental

monitoring

Text books

1 Rajmohan Joshi Biosensors (1e) Gyan Books 2006

2 Cooper JM and Anthony EG Biosensors (2e) Oxford University Press 2004

3 Turner APF KarubeI and WilsonGS Biosensors Fundamentals and applications Oxford Univ

Press 1990

4 SadanaA Biosensors Kinetics of Binding and Dissociation Using Fractals (1e) Elsevier BV

1995

5 Ashok M and Kim Rogers Enzyme amp Microbial Biosensors Techniques and Protocols (Methods

in Biotechnology) (1e) Humana Press 1998

6 Ashok M and Kim Rogers Affinity Biosensors Techniques and Protocols (Methods in

Biotechnology) (1e) Humana Press 1998

7 Damia Barcelo Biosensors for the Environmental Monitoring of Aquatic Systems Bioanalytical

and Chemical Methods for Endocrine Disruptors (1e) Springer 2009

BT-6711 Nanobiotechnology

Unit-I

Introduction

Nano - definition The fundamental Science behind nanotechnology- electrons atomsand ions

molecules metals biosystems Synthesis and Characterizations of Nanoscale Materials Strategies for

Nano architecture (top down and bottom up approaches) Fabrication Technologies and

Characterizations Self-assembly Systems Basic aspects of Nanofluidics surfactants polymers

emulsions and colloids Nanoscale Artificial Platforms Lipids in Self-assembly Structures

Nanoparticle synthesis in plants bacteria and yeast and its applications

Unit-II

Nano-structured materials

Fullerenes - Properties and CharacteristicsCarbon Nanotubes - Characteristics and Applications

Quantum Dots and WiresGold Nanoparticles Nanopores carbon nanotubes Applications of

NanoMolecules in Biosystems

Unit-III

Structural and functional principles of nanobiotechnology

Structural principle Factors governing biomolecular structure and stability Protein folding Self

assembly Self-organization Molecular recognition and Flexibility of biomaterials Functional

principles of Bionanotechnology Information driven nanoassembly Energetics Role of enzymes in

chemical transformation allosteric motion and covalent modification in protein activity regulation

Structure and functional properties of Biomaterials Bimolecular motors ATP Synthetase and

flagellar motors Traffic across membranes Potassium channels ABC Transporters and

Bactreriorhodapsin Bimolecular sensing Self replication Machine-Phase Bionanotechnology

Unit-IV

Bionanomachines and their Basic

Negligible gravity and inertia atomic granularity thermal motion water environment and their

importance in bionanomachines The role of proteins amino acids nucleic acids lipids and

polysaccharides in modern biomaterials Overview of natural Bionanomachines Thymidylate

Sythetase ATP synthetase Actin and myosin Opsin Antibodies and Collagen

Unit-V

Biophotonics and Bioimaging

Overview of imaging biological systems from the cellular level through to wholebody medical

imaging Introduction to biophysics basic physical concepts in imaging Major techniques using

ionizing and non-ionizing radiation fluorescence and multi-photon microscopy spectroscopy OCT

MRI X-ray CT PET and SPECT imaging

Unit-VI

Application of Nanobiotechnology

Nano-biotechnology in drug Delivery Nanoscale Devices for Drug Discovery Micelles for Drug

Delivery Protein targeting Small Molecule-Protein Interactions Micro-array and Genome Chips

Nanotechnology and the Cell Cell Motility Nano Motors and Cellular Navigation hemotaxis -

Transmembrane Signalling and Related Protein Nanotechnology for Cancer Diagnostics and

Treatment Nanotechnology for Cancer Research and Therapy siRNA Tumor-targeted Drug

Delivery Systems Nanotechnology for Imaging and Detection

Text Books

1 NANO by TPradeep 2006Tata Mc Graw Publishers India

2 Nanobiotechnology Concepts Applications and Perspectives Christof MNiemeyer Chad

AMirkin (eds) Wiley-VCH Weinheim (2004)

3 Kamali Kannangara Geoff Smith Michelle Simmons Burkhard Raguse

4 Overseas Press (2005)

5 David S Goodsell Bionanotechnology John Wiley amp Sons 2004

6 Greco Ralph S Nanoscale Technology in Biological Systems CRC Press 2005

BT-6721 Environmental Biotechnology

Unit-I

Basic concepts of ecology Interaction between environment and biota Concept of habitat and

ecological niches Limiting factor Energy flow food chain food web and trophic level NPC and S

cycles in nature Ecosystem dynamics and management Environmental impact assessment

Principles of conservation Conservation strategies sustainable development Global environmental

problems ozone depletion UV-B radiation green house effect and acid rain their impact in

biotechnological approaches for management

Unit-II

Environmental pollution

Types of pollution and pollution analysis ndash noise air and gaseous pollution Noise pollution Source

measurement impact on ecosystem and control Air pollution Types source method of sampling

measurement impact on ecosystem and control Control of noise and air pollution by

biotechnological methods Gaseous pollutants and odours General sources methods of control

fundamentals of adsorption mechanism of adsorption equilibrium isotherms break through curve

adsorption equipment regeneration of adsorbent application of adsorption for control of gaseous

and odour emission

Unit-III

Water pollution Impurities in water water pollution by industrial waste examination of water

collection of water samples water analysis ndash physical chemical and biological Standards of water

quality Water treatment processes Primary treatment screening skimming with coagulants

flocculation filteration aeration and disinfection Secondary treatment Aerobic processes ndash

activated sludge oxidation ditches recirculating system trickling filter towers rotating discs

rotating drums oxidation ponds Anaerobic digestion anaerobic filters Up flow anaerobic sludge

blanket reactors Tertiary treatment Activated carbon treatment reverse osmosis and electro dialysis

Unit-IV

Bioremediation

In situ and ex situ bioremediation technologies for various pollutants and sites bioremediation of oil

spills and heavy metal pollution use of microbes in bioremediation hydroponic system pollution

control boards and pollution control acts

Unit-V

Solid waste management sewage sludge treatment and utilization refuse disposal excreta disposal

in unsewered area composting and vermiculture biodegradation of noncellulosic wastes for

environmental conservation and fuel bioconversion of cellulosic wastes into protein and fuel

bioremediation of contaminated soils and waste lands radioactive product waste disposal

Unit-VI

Effluent treatment Sources of pollution impact on ecosystem and treatment of following industrial

effluents starch paper and pulp tannery dairy distillery oil refineries and pharmaceutical

Microbes in mining ore leaching oil recovery biopolymers biosurfactants

Text Books

1 Bruce E Rittmann and perry L Mccarty ldquoEnvironmental Biotechnology Principle and

Applicationsrdquo McGraw Hill publishing company Ltd2001

2 Mecalf and Eddy Inc ldquoWastewater Engineering Treatment Disposal Reuserdquo McGraHill

publishing company Ltd1991

3 Des W Connell ldquoBasic concepts of Environmental chemistryrdquo Lewis publishers2005

4 Michal J PelczarECS ChanNoel RKriegTata McGraw Hill publishing company Ltd1993

5 Alan Scragg Environmental BiotechnologyOxford University press2005

6 Prescott Harley Klein Microbiology WCB publishers1996

7 Richard T Wright and Bernard J Nebel ldquoEnvironmental Science towards a Sustainable Futurerdquo

Prentice Hall of India 2004

BT-624-Bioprocess Engineering Lab

1 To determine the concentration of protein content by Lowry method

2 To determine the concentration of sugar by 3 5 dinitrosalicylic acid method

3 To determine the optimum pH for given enzyme sample

4 To determine the optimum temperature for given enzyme sample

5 To study the immobilization of invertase enzyme

6 Measurement of citric acid production by Aspergillus niger with TLC

7 Determination of thermal death point (TDP) of the given microorganism

8 Production of ethanol from yeast fermentation of sugars

9 To prepare the growth curve of micro-organism cultured in a shake flask

10 To study the kinetics of lipase enzyme

BT-673- Environmental Biotechnology Lab 1 Environmental Impact Assessment Measurement of Air and Noise Pollution

2 Analysis of water temperature and pH

3 Measurement of Conductivity and TDS in water

4 Measurement of Dissolved Oxygen

5 Measurement of Carbondi Oxide and Hardness of water

6 Measurement and analysis of Ammonia and Ammonium in water

7 Measurement of Nitrite Nitrate and Total Nitrogen in water

8 Biochemical Oxygen Demand and Chemical Oxygen Demand measurements and analysis

9 Analysis of any one industrial effluent

10 Production of methane from sewage sludge

11 Vermicomposting

BT-674 Minor Project- I

SEMESTER III

BT-721 1 Elective ndash Bioseparation Technology Unit- I

Role of Downstream Processing in Biotechnology

Role and importance of downstream processing in biotechnological processes Problems and

requirements of bioproduct purification Economics and downstream processing in Biotechnology

Cost cutting strategies characterstics of biological mixtures process design criteria for various

classes of bioproducts (high volume-low value products and low volume- high value products)

physicochemical basis of bioseparation processes

Unit- II

Primary Separation and Recovery Processes

Cell disruption methods for intracellular products removal of insolubles biomass (and particulate

debris) separation techniques flocculation and sedimentation centrifugation and filtration methods

Precipitation methodsPrecipitation with salts organic solvents amp polymers

Unit- III

Extraction

Batch extractions staged extractions-cross current co current counter current extractions

Differential extractions fractional extractions with a stationary phase fractional extractions with two

moving phases Aqueous two-phase extraction reverse micelle extraction supercritical fluid

extraction in-situ product removalintegrated bioprocessing

Unit- IV

Membrane-based separations (micro- and ultra-filtration)

Theory design amp configuration of membrane separation equipment applications

reverse osmosis dialysis electro dialysis Isoelectric focusing

Unit- V

Adsorption

Adsorption isotherms industrial adsorbents adsorption equipments for batch and continuous

operations (co current and counter current) adsorption in fixed beds

Unit- VI

Chromatography

Principles of chromatographic separation ndash gel filtration reversed phase hydrophobic interaction

ion-exchange expanded bed adsorption bio affinity and IMAC supercritical fluid chromatography

Text books

1 Belter PA Cussler E and Wei Shan Hu Bioseparation ndash Downstream Processing for

Biotechnology Wiley Interscience 1988

2 Asenjo and Juan A Asenjo Separation Processes in Biotechnology CRC Press 1990

3 Wankat PC Rate Controlled Separation Kluwer Publishers 1990

4 Wang DIC Cooney CL Demain AL DunnilP Humphery AE and Lilly MD Fermentation

and Enzyme Technology John Wiley and Sons 1979

BT-721 2 Elective - Industrial Waste water treatment

UNIT I

Waste disposal management Methods of waste disposal industrial waste (solid liquid and gaseous

emission) effect of industrial wastes on streams and sewerage systems Treatment system of waste

disposal eg Incenerator differences in waste quality and quantity physico-chemical and biological

treatments of waste and their evaluation in respect of treatment

UNIT II

Characteristic features of wastes (solid liquid and gaseous emission) manufacturing processes and

toxic byproducts generated from iron ore alumina heavy metals units paper and pulp industries

pesticides industry thermal power station distillery textile and crude oil industry

UNIT III

Small and large scale industries for waste reduction and remediation various methods for waste

alteration volume and strength minimization recycling plants material restoration and conservation

Methods for neutralisation equalization precipitation and solidification for waste handling

Economic sustainability and government support for joint treatment of raw effluent municipal

sewage and debris

UNIT IV

Unit operations and their design for treatment and management of wastes (solid liquid and gaseous)

UNIT V

Landfill design and operation including site selection engineered sites liners and covers leachate

control and treatment gas recovery and control including utilization of recovered gas (energy) and

landfill monitoring and reclamation

UNIT VI

Case studies

Text Books

1 S P Mahajan ldquoPollution Control in Process Industriesrdquo Tata Mc Graw Hill Publications

2 W Wesley Eckenfelder Jrrdquo Industrial Water Pollution Controlrdquo Mc Graw Hill Publications

3 Ronald W Crites Sherwood C Reed and Robert Bastion ldquoLand Treatment Systems for Municipal

amp Industrial Wastesrdquo Mc Graw Hill Publications

4 Neal K Ostler ldquoIndustrial Waste Stream Generationrdquo Prentice Hall

5 Rao and Dutta ldquoIndustrial waste treatmentrdquo Oxford and IBH Publishing Co Pvt Ltd New Delhi

6 Dr A D Patwardhan ldquoindustrial Waste Water Treatmentrdquo Prentice Hall of India

BT-721 3 Elective-Biopolymer Technology Unit-I

Introduction

Biopolymers ndash The current scenario different biopolymers ndash produced from various renewable

resources characteristics merits and demerits over conventional polymers

Unit-II

Biopolymer Technology and Applications

Biopolymers and Artificial Biopolymers in Biomedical Applications an Overview Novel Synthesis

of Biopolymers and Their Medical Applications Composite Films Based on Poly (Vinylalcohol) and

Lignocellulosic Fibres Preparation and Characterizations Composite Materials Based on Gelatin

and Fillers from Renewable Resources Thermal and Mechanical Properties Properties of PHAs and

Their Correlation to Fermentation Conditions

Unit-III

Biosynthesis and Modifications

Synthesis and modification of different Biopolymers like xanthum gum

Unit-IV

Biosurfactants

Source characteristics and properties of Biosurfactants Production of Biosurfactants via the

fermentation and biotransformation routes Production of Biosurfactants with immobilized cells

Integrated bioprocess for continuous production of Biosurfactants including downstream processing

Applications of Biosurfactants-Food Industry Environmental Control

Unit-V

Bioplastic

Different types of bioplastics Starch-based plastic Cellulose-based plastic Aliphatic polyesters

Poly-3-hydroxybutyrate (PHB) Polylactic acid (PLA) Polyamide Bio-derived polyethylene

Advantages of bioplastic over petroleum-based polymer Mechanism of synthesis of Poly (-

hydroxybutyric acid) (PHB)

Unit-VI

Material Testing and Analytical Methods

An Overview of Available Testing Methods Comparison of Test Systems for the Examination of the

Fermentability of Biodegradable Materials Structure- Biodegradability Relationship of biopolymers

Text Books

1 Emo Chiellini Emo Chiellini and Helena Gil Biorelated Polymers Sustainable Polymer Science

and Technology Springer 2001

2 Johnson RM LY Mwaikambo and N Tucker Biopolymers Rapra Technology 2003

3 Naim Kosaric (Ed) Biosurfactants Marcell Dekker Inc 1993

BT-721 4 Elective ndash Bioprocess Plant Designing Unit-I

Process development

Introduction to Design ndash nature of design ndash Technical feasibility survey Mass and energy balance

process development ndash data acquisition ndash design data information of project - Organization of project

ndash Project documentation ndash codes and standards

Unit-II

Design Development

Equipment selection and specifications-materials of construction ndash flow sheeting - piping and

instrumentation ndash process safety and loss prevention

Unit-III

General site consideration

Introduction ndash plant location and site selection ndash site layout- plant layout utilities ndash environmental

considerationsndash waste management ndash visual impact ndash government regulations and other legal

restrictions community factors and other factors affecting investment and production costs ndash human

resources

Unit ndashIV

Selection and specification

Selection and specification of equipment for handling fluids and solids Selection specification

design of heat and mass transfer equipment used in bioprocess industries Design of facilities for

cleaning of process equipment used in biochemical industries Utilities for biotechnology

Unit-V

Design of fermenters

Design of fermentation Design considerations for maintaining sterility of processing equipment

Unit-VI

Process economics

Production plants Bioprocess validation Safety considerations

Text books

1 Applied Process Design for Chemical and Petrochemical Plants by EE Ludwig Publisher

Butterworth-Heinemann

2 Chemical Engineering by RK Sinnott JM Coulson and JF Richardsons Publisher

Butterworth-Heinemann Vol-6 Butterworth Heinemann III editionndash 2002

3 Peters and Timmerhaus Plant Design and Economics for Chemical Engineers Mcgraw Hill

4thEdition 1989

4 Rudd and Watson Strategy of Process Engineering Wiley 1987

BT-721 5 Elective- Transport Phenomenon Unit -I

Diffusion

Molecular and turbulent diffusion Diffusion coefficient Flickrsquos Law of diffusion Dependence of

diffusion coefficient on temperature pressure and composition Diffusion in multi-component gas

mixtures Diffusion in solids Molecular Knudsen ampsurface diffusion Inter- phase mass transfer

Mass transfer coefficients Diffusion between phases Equilibrium solubility of gases in liquids

Mass Transfer theories Mass transfer in fluidized beds flow past solids and boundary layers

Simultaneous heat and mass transfer Mixing in a Bioreactor -Flow regimes with and without baffles

various types of impellers and mixing equipment Power Requirements for Mixing Ungassed

Newtonian Fluids Gassed Fluids Improving Mixing in Fermenters Effect of Rheological Properties

on Mixing Role of Shear in Stirred Fermenters

Unit-II

Drying and Crystallization

Solid-gas equilibria Different modes of drying operation Types of batch and continuous dryer

Definitions of moisture contents Rate of batch drying Time of drying Mechanism of batch drying

Continuous drying Equilibrium yield of crystallization Heat and mass transfer rates in

crystallization Theories of crystallization Factors governing nucleation and crystal growth rates

controlled growth of crystal Classification of crystallizers

Unit ndashIII

Absorption and Adsorption

Gas-Liquid equilibriaHenryrsquos Law Selection of solvents Absorption in tray column Graphical and

analytical methods Absorption in packed column Design equation for packed column HTU NTU

and HTEP concepts Equipments Description of adsorption process and their application Types of

adsorption Nature of adsorbents Adsorption equilibrium and adsorption hysterises Stage wise and

continuous contact adsorption operation operations Determination of number of stages Equipments

Unit-IV

Momentum transfer

Review of basic concepts ndash Conservation of Mass Conservation of Energy Momentum Balance ndash

Momentum Balance in a Circular Pipe Flow Velocity Profile Fermentation Broth Rheology ndash

Viscosity Rheological Properties of Fermentation Broths Factors affecting broth viscosity

Unit V

Conduction and Convection

Introduction Conduction Basic concepts of conduction in solids liquids and gases One and two

dimensional heat conduction Critical and optimum insulation thickness Introduction to unsteady

state heat transfer Principles of convection Equations of forced and free convection

Unit ndashVI

Radiation

Basic laws of heat transfer by radiation black body and gray body concepts solar radiations

combined heat transfer coefficients by convection and radiation Introduction of Heat Transfer

Equipments Heat Exchangers Evaporators Condenser

Text Books

1 Holman JP ldquoHeat Transferrdquo 9 th ed McGraw Hill (1989)

2 Treybal R ldquoMass Transfer Operationsrdquo 3rd ed New York McGraw-Hill (1980)

3 McCabe Smith Unit Operations in Chemical Engineering McGraw Hill

4 Foust A S etal ldquoPrinciples of Unit Operationsrdquo John Wiley (1980)

5 R B Bird et al Transport Phenomena 2nd Edition Wiley(2006)

BT-721 6 Elective ndash Biochemical thermodynamics Unit-I

Fundamental concepts of Thermodynamics

System and Surroundings First law of thermodynamics -Internal energy enthalpy Heat capacity

applied examples from biochemistry Second law ndash Entropy and universe Concept of heat engines

protein stability and calorimetric measurements Fundamentals of Differential scanning calorimeter

and Isothermal calorimeter in biological property measurements Third law of thermodynamics

Maxwell equations Gibbs-Duhem Equation and the Phase Rule Legendre Transforms

Unit-II

Non-equilibrium Thermodynamics

Reversible work exact differentials and function of state first and second law The electrochemical

potential External forces and steady state Fickrsquos Law chemical reactions in the steady state internal

entropy production cells as non-equilibrium stationary states Diffusion and membrane transport

Biological Systems as Open Non-equilibrium Systems Failure of classical thermodynamics in

describing biological processes Standard free energy changes and equilibrium constants direction

and rate

Unit-III

Bioenergetics

Energetics of metabolic pathways ndash energy coupling (ATP amp NADH) stoichiometry ndashenergetic

analysis of cell growth and product formation ndash elemental balances Degree ofreduction concepts

available- electron balances yield coefficients oxygen consumptionand heat evolution in aerobic

cultures thermodynamic efficiency of growth Thermodynamics of Biological Systems

Thermodynamic analysis of oxidative photophosphorylation stability of non-equilibrium stationary

states ordering in time and space far from equilibrium glycolytic oscillations Biological clocks

routes to chaos

Unit-IV

Chemical Potential

Visualization of the potential Steady velocity and steady flow Fickrsquos law and diffusion Local

Equilibria and Steady State Energy vs Power Transducers in biological states Constitutive

equations Dynamic efficiency and Onsager (nonequilibrium thermodynamics) Prigoginersquos principle

Spontaneous coupling and entropy production

Unit-V

Gibbs free energy and its Applications

Gibbs free energy and equilibrium Chemical potential ionic solutions Equilibrium constant

standard state in biochemistry Acid and bases chemical coupling and redox reactions Gibbs free

energy in photosynthesis glycolysis citric acid cycle Oxidative phosphorylation and ATP

hydrolysis substrate cycling Membrane transport Enzyme substrate interaction Haemoglobin

Protien solubility stability and dynamics

Unit-VI

Reaction Kinetics

Rate of a reaction rate constant and order of the reaction effect of temperature collision and

transition state theory Electron transfer kinetics Enzyme kinetics and inhibition Reaction

mechanism of lysozyme protein folding and pathological misfolding polymerisation muscle

contraction and the molecular motors

Text Books

1 Smith JM Van Ness HC Abbot MM Chemical Engineering Thermodynamics 6th Edition

McGraw-Hill 2001

2 Narayanan KV A Text Book Of Chemical Engineering Thermodynamics Prentice Hall India

2001

3 Sandler SI Chemical And Engineering Thermodynamics John Wiley1989

4 Bailey amp Ollis Biochemical Engineering Fundamentals II edition Megraw Hil ndash 1986

5 Donald T Haynie Biological Thermodynamics Cambridge press 2008

6 Robert A Alberty Thermodynamics of Biochemical Reactions John willy publications 2003

7 Bioenergetics by AL Lehninger Publisher WA Benjamin Inc

8 Biological Thermodynamics by DT Haynie Publisher Cambridge University Press

9 Biophysical Chemistry by CR Cantor and PR Schimmel Publisher

10 FreemanThermodynamics and Kinetics for the Biological Sciences by GG Hammes Publisher

John Wiley and Sons Inc

BT-7221 Elective - Bioethics Biosafety and IPR Unit I

Introduction to ethics and bioethics

Personal ethics profession and professionalism -Moral Reasoning -Ethical theories - person as an

experimenter -Moral leadership (integrity and ingenuinity) ndash framework for ethical decision making

Biotechnology and ethics Biotechnology in agriculture and environment benefits and risks ndash

benefits and risks of genetic engineering ndash ethical aspects of genetic testing ndash ethical aspects relating

to use of genetic information ndash genetic engineering and biowarfare

Unit-II

Ethical implications of cloning

Reproductive cloning therapeutic cloning Ethical legal and socio-economic aspects of gene

therapy germ line somatic embryonic and adult stem cell research- GM crops and GMO‟s ndash

biotechnology and biopiracy ndash ELSI of human genome project

Unit-III

Introduction to biosafety

Biosafety issues in biotechnology ndash risk assessment and risk management ndash safety protocols risk

groups ndash biosafety levels ndash biosafety guidelines and regulations (National and International) ndash

operation of biosafety guidelines and regulations ndash types of biosafety containment International

guidelines with regard to rDNA technology transgenic science GM crops etc Experimental

protocol approvals levels of containment Guidelines for research in transgenic plants Good

manufacturing practice and Good lab practice (GMO and GLP)

Unit-IV

Introduction to intellectual property and intellectual property rights

Types patents copy rights trade marks design rights geographical indications ndash importance of IPR

ndash patentable and non patentables ndash patenting life ndash legal protection of biotechnological inventions ndash

world intellectual property rights organization (WIPO) Plant breederrsquos rights Legal implications

Biodiversity and farmers rights Examples of patents in biotechnology Special application of patent

laws in biotechnology Licensing and cross licensing Flavr SavrTm- Tomato as model case and case

studies

Unit-V

Public acceptance issues for biotechnology

Environmental aspects of biotech application Use of genetically modified organisms and their

release in environment Case studies or experiences from developing and developed countries

Biotechnology and hunger Challenges for the Indian Biotechnological research and industries

Unit-VI

Socioeconomic impacts of biotechnology

The legal and socioeconomic impacts of biotechnology public education of the processes of

biotechnology involved in generating new forms of life for informed decision making

Text Books

1 Ethics in engineering Martin MW and SchinzingerR III Edition Tata McGraw- Hill New

Delhi 2003

2 Biotechnologies and Development UNESCO Publications 1988

3 A Biotechnologies in developing countries present and future UNESCO Publishers 1993

4 Singh K Intellectual property rights on Biotechnology BCIL New Delhi

BT-722 4 Elective ndash Metabolic Engineering Unit ndash I

Cellular metabolism

An overview of cellular metabolism-transport processes- Fueling reactions -glycolysis-fermentative

pathways-TCA cycle and oxidative phosphorylation-anaplerotic pathways -catabolism of fats

organic acids and amino acids -biosynthetic reactions of amino acids ndash nucleic acids fatty acids and

other building blocks -polymerization - growth energetics

Unit ndash II

Comprehensive models for cellular reactions

Stoichiometry of cellular reactions -reaction rates-dynamic mass balances-Yield coefficients and

linear rate equation Material Balance and data consistency ndashblack box model elemental balance -

heat balance -analysis of over determined systems - identification of gross measurement errors

Unit ndash III

Regulation of metabolic pathways

Overview of enzyme kinetics ndash simple reversible inhibition systems ndash irreversible inhibition ndash

allosteric enzymes cooperativity ndash regulation of enzyme concentration ndash transcription initiation ndash

translation regulation at whole cell level ndash regulation of metabolic networks enhancements of

product yield and productivity for ethanol and amino acids pathways metabolic pathway

manipulations to extend substrate range product spectrum and novel products improvement of

cellular properties

Unit ndash IV

Metabolic flux analysis

Theory ndash overdetermined systems ndash underdetermined systems ndash sensitivity analysis ndash methods for the

experimental determination of metabolic fluxes by isotope labeling direct flux determination from

fractional enrichment ndash applications involving complete enumeration of metabolite isotopomers ndash

carbon metabolite balances Applications of metabolic flux analysis ndash amino acid production by

Glutamic acid Bacteria

Unit ndash V

Metabolic control analysis

Fundamentals of Metabolic control analysis -determination of flux control coefficients ndash MCA of

Linear pathways ndash branched pathways ndash theory of large deviation

Unit-VI

Applications of metabolic engineering

Text Books

1 Gregory N Stepanopoulos Aristos A Aristidou Jens Nielsen Metabolic Engineeing

2 Principles and methodologies Academic Press 1998

3 Wang DIC Cooney CL Demain AL DunnilP Humphery AE Lilly MD

4 ldquoFermentation And Enzyme Technologyrdquo John Wiley And Sons 1980

5 Zubay G ldquoBiochemistryrdquo Macmillan Publishers 1989

BT-722 3 Elective ndash Protein Engineering Unit-I

Bonds and Energies in protein

Covalent Ionic Hydrogen Coordinate hydrophobic and Vander walls interactions in protein

structure Interaction with electromagnetic radiation (radio micro infrared visible ultraviolet X-

ray) and elucidation of protein structure

Unit-II

Amino acids and their characteristics

Amino acids ndash structure with three and single letter codes- molecular properties (size solubility

charge pKa) Chemical reactivity in relation to post-translational modification (involving amino

carboxyl hydroxyl thiol imidazole groups) and peptide synthesis

Unit - III

Protein architecture

Primary structure peptide mapping peptide sequencing - automated Edman method amp massspec

High-throughput protein sequencing setup Secondary structure Alpha beta and loop structures and

methods to determine Super-secondary structure Aphaturn- alpha beta-turn-beta (hairpin) beta-

sheets alpha-beta-alpha topology diagrams up and down amp TIM barrel structures nucleotide

binding folds prediction of substrate binding sites Tertiary structure Domains folding denaturation

and renaturation overview of methods todetermine 3D structures Quaternary structure Modular

nature formation of complexes

Unit-IV

Structure-function relationship

DNA-binding proteins prokaryotic transcription factors Helix-turn-Helix motif in DNA binding

Trp repressor Eucaryotic transcription factors Zn fingers helix-turn helix motifs in homeodomain

Leucine zippers Membrane proteins and receptors bacteriorhodopsin and Photosynthetic reaction

center Immunoglobulins IgG Light chain and heavy chain architecture abzymes and Enzymes

Serine proteases understanding catalytic design by engineering trypsin chymotrypsin and elastase

substrate-assisted catalysis other commercial applications

Unit -V

Identification and analysis of proteins

Identification and analysis of proteins by 2D analysis Spot visualization and picking Tryptic

digestion of protein and peptide fingerprinting Mass spectrometry ion source (MALDI spray

sources) analyzer (ToF quadrupole quadrupole ion trap) and detector

Unit-VI

Tools in proteomics and genomics

Site directed mutagenesis for specific protein function Basic concept for designing a new

proteinenzyme molecule Specific examples of enzyme engineering Tryesyl t RNA synthetase

Dihydrofolate reductase Subtilisin Advantages ndash protein data base analysis ndash methods to alter

primary structure of proteins examples of engineered proteins thermal stability of T4-lysozyme

recombinant insulin to reduce aggregation and inactivation de novo protein design ndash principles and

examples

Text Books

1 Voet D and Voet G Biochemistry Third edn John Wiley and Sons 2001

2 Moody PCE and Wilkinson AJ Protein Engineering IRL Press Oxford UK 1990

3 Branden C and Tooze J Introduction to Protein Structured Second Edition GarlandPublishing

NY USA 1999

4 Creighton TE Proteins Freeman WH Second Edition 1993

BT-7222 Elective ndash Quality Management Unit-I

Quality Concepts

Definition of Quality Dimensions of Quality Quality Planning Quality costs ndash Analysis

Techniques for Quality Costs Evolution of Quality Control Basic concepts of Total Quality

Management Historical Review Leadership ndash Concepts Role of Senior Management Quality

Council Quality Statements Strategic Planning Deming Philosophy Barriers to TQM

Implementation Control on Purchased Product Procurement of various products evaluation of

supplies capacity verification Development of sources procurement procedure Manufacturing

Quality Methods and techniques for manufacture inspection and control of product quality in sales

and services guarantee analysis of claims

Unit-II

Quality Management

Organization structure and design quality function decentralization designing and fitting

organization for different type products and company economics of quality value and contribution

quality cost optimizing quality cost seduction program Human Factor in quality Attitude of top

management cooperation of groups operators attitude responsibility causes of apparatus error and

corrective methods

Unit-III

Control Charts

Theory of control charts measurement range construction and analysis of R charts process

capability study use of control charts

Attributes of Control Chart

Defects construction and analysis of charts improvement by control chart variable sample size

construction and analysis of C charts

Unit -IV

Defects diagnosis and prevention defect study identification and analysis of defects correcting

measure factors affecting reliability MTTF calculation of reliability building reliability in the

product evaluation of reliability interpretation of test results reliability control maintainability zero

defects quality circle

Unit-V

Statistical process control

The seven tools of quality Statistical Fundamentals ndash Measures of central Tendency and Dispersion

Population and Sample Normal Curve Control Charts for variables and attributes Process

capability Concept of six sigma New seven Management tools

Unit-VI

Quality system

Need for ISO 9000 and Other Quality Systems ISO 90002000 Quality System ndash Elements

Implementation of Quality System Documentation Quality Auditing QS 9000 ISO 14000 ndash

Concept Requirements and Benefits

Text Books

1 Lt Gen H Lal ldquoTotal Quality Managementrdquo Eastern Limited 1990

2 Greg Bounds ldquoBeyond Total Quality Managementrdquo McGraw Hill 1994

3 Menon HG ldquoTQM in New Product manufacturingrdquo McGraw Hill 1992

4 Dale HBesterfiled et at Total Quality Management Pearson Education Asia 1999

5 James REvans amp William MLidsay The Management and Control of Quality (5thEdition)

South-Western (Thomson Learning) 2002 (ISBN 0- 324-06680-5)

6 FeigenbaumAV ldquoTotal Quality Management McGraw-Hill 1991

7 OaklandJS ldquoTotal Quality Management Butterworth ndash Hcinemann Ltd Oxford 1989

8 Narayana V and Sreenivasan NS Quality Management ndash Concepts and Tasks New Age

International 1996

9 Zeiri ldquoTotal Quality Management for Engineers Wood Head Publishers 1991

BT-722 5 ElectivendashDesign and Development of Biological Treatment process

Unit-I

Bacterial metabolism in wastewater treatment systems

Introduction decomposition of organic carbon compounds in natural and manmade systems aerobic

and anaerobic decomposition of glucose protein carbohydrates proteins lipids etc Nitrogen

removal during treatment enhanced biological phosphate removal biological removal bio-

transformations and biosorption of metal ions aerobic and anaerobic degradation of xenobiotics

Unit-II

Activated sludge process

Single and two stage process special developments technological and microbiological aspects plant

configurations design

Unit-III

Modeling of aerobic waste water treatment process

Introduction purpose of modeling activated sludge model presentations waste water characteristics

various disinfection methods for waste water

Unit-IV

High rate anaerobic waste water treatment

Introduction basic principles reactor design parameters reactor operation

Unit-V

Biological Nutrient removal

Suspended growth and attached growth nutrient removal processes and design criteria ndash Nitrogen

(Nitrification and denitrification) and Phosphorus precipitation biological) Biological removal of

toxic and recalcitrant organic wastes

Unit-VI

Water reuse

Wastewater reclamation risk assessment various reclamation technologies storage agricultural

reuse industrial reuse groundwater recharge

Text book

1 Joumlrdening HJ and JWinter Environmental Biotechnology - Concepts and Applications

Cambridge University Press 2006

2 George Tchobanoglous and Franlin L Burton Wastewater Engineering- Treatment Disposal and

Reuse Tata McGraw Hill Publishing Co Ltd 1990

BT-722 6 Elective ndash Bioinformatics

Unit I

Introduction to Biological Databases Types Overview of Biological Databases and Retrieve

Nucleic acid databases NCBI PubMed Entrez Blast OMIM Books Taxonomy Structure

Locuslink Protein Databases- Primary Functional Composite Secondary Structural classification

database Sequence Formats amp storage Sequence submission to sequence Database

Unit II

Genomics Structure of DNA Polymorphisms in DNA Sequence Human Genome Project

Complete Genome Sequences Functional Annotation

Unit III

Human Genetic Variation Databases and Concepts Introduction Forms and mechanisms of

genetic variation Databases of human genetic variation SNP databases Mutation databases Genetic

marker and microsatellite databases Nonnuclear and somatic mutation databases Tools for SNP and

mutation visualization

Unit IV

Biological Sequence Analysis amp Characterization Predictive Functional Analysis of coding and

non-polymorphisms Amino Acid Properties and Consequences of Substitutions

Unit V

Genetics Genomics Interfaces Technologies for the measurement of gene expression The Cancer

Genome Anatomy Project (CGAP) The Human Transcriptome Map Protein Interaction Networks

Computational methods for pathways and systems biology databases and web resources

Unit VI

Soft computation Neural Networks and Machine learning support vector machines fuzzy logic

evolutionary computing genetic algorithms- applications to data mining and bioinformatics

Text Books

1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves Noah Hardy

ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd

2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS ISBN978-81-8318minus831minus9

Himalaya Publication House Discovering Genomics Proteomics and Bioinformatics Campbell

ISBN978813171 5598 Pearson Education

3 Proteomics Theory and Practice Gomase VS and Chikhale NJ Himalaya Publication House

4 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978- 3-527-30541-4

John Wiley amp Sons India Pte Ltd

5 Introduction to Bioinformatics Arthur M Lesk Oxford University Press 2003

6 Sequence and Genome Analysis by David W Mount - Cold Spring Harbor Laboratory 1st edition

2004

7 Bioinformatics A Practical Guide to the Analysis of Genes and Proteins by Andreas D

Baxevanis B F Francis Ouellette Wiley-Interscience 3rd Edition 2004

8 Sequence structure and Database ndash Des Higgins Willice Taylor Oxford press 1st edition (2003)

9 Fundamental Concepts of Bioinformatics - Dan E Krane Michael L Raymer Pearson education

First edition (2004)

BT-723 Self Study Open Area Seminar-II

BT-724 Minor Project- II

BT-725 Major Project- I

SEMESTER IV

BT-821 Major Project- II

1

Scheme of Examination amp Syllabus

MTech in Bioinformatics

Delhi Technological University

Main Bawana Road

Delhi -110042

2

MTech in Bioinformatics

Bioinformatics is an emerging discipline of biological science and computer science

mathematics and statistics with the objectives of developing tools to analyze several types

of biological data and generate new knowledge for existing life in universe

Bioinformatics has two subfields the development of computational tools and databases

and the application of these tools and databases in generating biological knowledge to

better understanding living systems These fields are complementary to each other The

tools development includes writing software for sequence structural and functional

analysis as well as construction and curating of biological databases

It is clear that the promise of bioinformatics and advanced level RampD in its field will be

fulfilled by those who have sound background of Biological science computer science

mathematics and statistics The proposed syllabus has been developed to address the

need of well trained bioinformaticians cutting edge RampD for this field bioinformatics

entrepreneurship and bioinformatics-business management The trained manpower will

be well versed in techniques of modern biology biochemistry strong skills in

combinatorial computing and search and retrieval techniques in large biological

databases

3

Delhi Technological University Delhi

Department of Biotechnology

Scheme of Examination

MTech in Bioinformatics

Semester I

Sem I Course

Code

Subject

L T P Internal

Marks

End

sem

Marks

Total

Marks

Credits

Group A BT-501 Advanced Proteomics 3 0 0 50 100 150 3

BT-502 Bioinformatics I 3 0 0 50 100 150 3

BT-503 Population Genetics 3 0 0 50 100 150 3

BT-504 Bioinformatics I

Laboratory

0 0 2 30 70 100 2

Group B BT-551 Biostatistics 3 0 0 50 100 150 3

BT-552 High-Throughput

Structural Biology

3 0 0 50 100 150 3

BT-553 High-Throughput

Structural Biology

Laboratory

0 0 2 30 70 100 2

BT-554 Self Study Open Area

Seminar

0 0 1 50 -- 50 1

Total 360 640 1000 20

4

Semester II

Semester III

Course

Code

Subject

L T P Internal

marks

End

sem

marks

Total

Marks

Credits

Group E BT-701 Professional Elective V 3 0 0 50 100 150 3

BT-702 Professional Elective VI 3 0 0 50 100 150 3

BT-703 Self Study Open Area

Seminar

0 0 2 100 --- 100 2

BT-704 Minor Project - II 0 0 2 -- 300 300 6

BT-705 Major Project-I 0 0 4 300 300 6

Total 200 800 1000 20

Course

Code

Subject

L T P Internal

Marks

End

sem

Marks

Total

Marks

Credits

Group C BT-601 Bioinformatics II 3 0 0 50 100 150 3

BT-602 Professional Elective I 3 0 0 50 100 150 3

BT-603 Professional Elective II 3 0 0 50 100 150 3

BT-604 Bioinformatics II

Laboratory

0 0 2 30 70 100 2

Group D BT-651 Professional Elective III 3 0 0 50 100 150 3

BT-652 Professional Elective IV 3 0 0 50 100 150 3

BT-653 Lab based on Elective

III

0 0 2 30 70 100 2

BT-654 Minor Project ndash I 0 0 1 50 -- 50 1

Total

360 640 1000 20

5

Semester IV

Subject

Code

Subject

L T P Internal

marks

End sem

marks

Total

marks

Credits

Group F BT-801 Major Project - II 0 0 15 400 600 1000 20

Total

400 600 1000 20

BT-602 Professional Elective I

BT-6021 Biological Database Management

BT-6022 Advanced Genetic Engineering

BT-6023 Web Application Development

BT-603 Professional Elective II

BT-6031 Computational Genomics

BT-6032 Drug Design and Discovery

BT-6033 Chemoinformatics

BT-651 Professional Elective III

BT-6511 Computer Aided Drug Design

BT-6512 Computer Graphics

BT-6513 Pharmacogenomics and Personalized Medicine

6

BT-652 Professional Elective IV

BT-6521 Combinatorial Methods in Biopharmaceuticals

BT-6522 Data Warehousing and Data mining

BT-6523 Genomics From Human Genome Project to Medical Applications

BT-653 Professional Elective-III Laboratory

BT-6531 Computer-Aided Drug Design Laboratory

BT-6532 Computer Graphics Laboratory

BT-6533 Pharmacogenomics and Personalized Medicine Laboratory

BT-654 Minor Project-I

BT-701 Professional Elective V

BT-7011 Immunoinformatics

BT-7012 Medical Bioinformatics

BT-7013 Advanced Genetic Engineering

BT-702 Professional Elective VI

BT-7021 Nanotechnology in health care

BT-7022 Resource Planning amp Management in Bioinformatics

BT-7023 Advanced Drug Delivery Systems

7

SYLLABUS

MTECH (BIOINFORMATICS)

Semester I

Group-A

BT-501 Advanced Proteomics

Unit I

Introduction The proteome and the Genome life and death of a protein protein a

modular structure functional protein families need for proteomics scope of proteomics

challenges of proteomics Strategies for protein separation Two-dimensional

polyacrylamide gel electrophoresis for proteome analysis Brief history of 2-DE 2-DE

with immobilized pH gradients sample preparation solubilization Reduction The first

dimension IEF with IPG Equilibration between dimensions The second dimension

SDS-PAGE resolution reproducibility of 2-DE liquid chromatography in proteomics

Unit II

Detection of proteins in polyacrylamide gels and on electroblot membranes Organic

dyes and silver stains Reverse stains Colloidal dispersion stains organic fluorophore

stains metal chelate stains Image analysis of two-dimensional gels Data acquisition

digital image processing Protein spot detection and quantification Gel matching Data

analysis data presentation data bases

Unit III

Enhancing high-throughput proteome analysis the impact of stable isotope labeling

Sample preparation two-dimensional gel separation and analysis Mass spectrometry

8

protein identification using MS data Mass spectrometry protein identification using

MSMS data Protein modification in proteomics Introduction phosphor-proteins

glycoproteins Ubiquitin etc

Unit IV

Protein-Protein interactions- Yeast two hybrid Co-Precipitation Phage Display

Phylogenetic Profile Domain fusion Gene Neighborhood Gene Cluster Mirror Tree

Analysis of genome wide Protein-Protein Interactions in yeast Genome wide yeast two

hybrid analysis of other organisms Protein fragment complementation assays

Unit V

Protein chips and functional proteomics Introduction different types of protein chips

detection and quantification of proteins bound to protein chips emerging protein chips

technologies

Unit VI

Applications of Proteome analysis Mining proteomes protein expression profile

identification of protein-protein interactions and protein complexes mapping proteins

complexes recent advances in Proteomics

Reference Books

1 Proteomics From Protein Sequence to Function by SR Pennington and MJ

Dunn Viva Books Private Limited (2001)

2 Introduction to Proteomics by Daniel C Liebler Humana Press

3 Discovering Genomics Proteomics amp Bioinfo AM Campbell CSH

Press(2003)

4 Handbook of Comparative Genomics Principles and Methodology by Cecilia

Saccone Graziano Pesole Wiley-LISS Publication (2003)

5 Comparative Genomics by Melody S Clark Kluwer Academic Publishers (2001)

9

BT -502 Bioinformatics I

Unit I

Introduction to Biological Databases Types Overview of Biological Databases and

Retrieve Nucleic acid databases NCBI Protein Databases- Primary Functional

Composite Secondary Ensembl Sequence Formats amp storage Sequence submission to

sequence Database

Unit II

Genomics Structure of DNA Polymorphisms in DNA Sequence Types of SNPs

Human Genome Project Genetic Association Studies HapMap Project

Unit III

Protein Functional Annotation and Characterization Gene Ontology GO

Annotations Manual Annotations Computational Annotation Methods Functional

Analysis of Datasets

Unit IV

Pairwise Sequence Alignment Local alignment Global alignment Scoring matrices

PAM BLOSUM Gaps Dot Plots Dynamic programming Approach Needleman and

Wunsch Algorithm Smith and waterman Algorithm Heuristic Approach BLAST

FASTA

Unit V

Multiple Sequence Alignment and Phylogenetic Analysis Algorithms for multiple

sequence alignments global and local alignment programs and methods for multiple

sequence alignment Algorithms for alignment Phylogenetic Analysis

Unit VI

Introduction to Perl Programming Introduction and Installation Arithmetic and

10

Logical operators Conditionals and Loops List and Arrays Working with files

Reference Books

1 Introduction to Bioinformatics Arthur M Lesk Oxford University Press 2003

2 Sequence and Genome Analysis by David W Mount - Cold Spring Harbor

Laboratory 1st edition 2004

3 Bioinformatics A Practical Guide to the Analysis of Genes and Proteins by

Andreas D Baxevanis B F Francis Ouellette Wiley-Interscience 3rd Edition

2004

4 Sequence structure and Database ndash Des Higgins Willice Taylor Oxford press 1st

edition (2003)

5 Fundamental Concepts of Bioinformatics - Dan E Krane Michael L Raymer

Pearson education First edition (2004)

6 Beginning Perl for Bioinformatics James Tisdall OrsquoReilly 1st Edn 2001

BT -503 Population Genetics

Unit I

Introduction Scope amp Premises of Population Genetics Genetic and Phenotypic

Variation Random Mating Loci and alleles Mutations and Polymorphisms Genotype

and Allele Frequencies Effect of Mutations on Fitness Rate of Spontaneous Mutation

Unit II

Population Structure The Hardy-Weinberg Principle Testing for Hardy-Weinberg

Equilibrium Extensions of the Hardy-Weinberg Principle Linkage and Linkage

Disequilibrium Genetic Drift The Wright-Fisher Model of Random Genetic Drift

Effective Population Size Gene Trees and Coalescence Mutation The Neutral Theory

Recombination Migration Inbreeding and Heterosis Darwinian Selection Selection in

Haploid Organisms Selection in Diploid Organisms Overdominance More Complex

Types of Selection Molecular Population Genetics Molecular Polymorphisms Patterns

of Change in Nucleotide and Amino Acid Sequences Polymorphism and Divergence

11

Molecular Phylogenetics Transposable Elements mtDNA Y-DNA Separating History

from Gene Flow

Unit III

Population Genomics and proteomics Genome-Wide Patterns of Polymorphism

Human Population Genetics Human Polymorphism Population Genetic Inferences from

Human SNPs Population Structure Inferred from Human Polymorphism Mendelian

Disease and Population Genetics Genetic Basis for Variation in Risk of Complex

Disease Human Origins

Unit IV

Evolutionary Analysis Quantitative Genetics Quantitative Genetics of Natural

Populations Quantitative Trait Loci (QTLs) Types of Quantitative Traits Genes That

Affect Quantitative Traits the Number of Genes Affecting Quantitative Traits Methods

for Mapping QTLs

Unit V

Selection Measures of Fitness amp Constant Fitness Models Nonrandom Mating Identity

by descent Inbreeding Selection on Quantitative Traits Pleiotropy and Developmental

Constraints Interactions of selection with other evolutionary forces The Shifting Balance

Theory The Unit of Selection Meiotic and Molecular Drive Sexual Frequency amp

Density Dependent Selection

Unit VI

Genetic Variability in Natural Populations Introduction Measures of Genetic

Variation Gene Diversity within Populations- Enzyme and Protein Loci Blood Groups

and other loci Genetic Diversity in Subdivided Populations Mechanisms of Maintenance

of Protein Polymorphisms Overdominance hypothesis Other types of Balancing

Selection Neutral Mutations Transient Polymorphisms due to selection

Reference Books

12

1 Evolutionary Analysis Scott Freeman John C Hendon Fourth Edition Pearson

Education

2 Molecular Genetic Analysis of Populations Hoelzel 2nd Edition Oxford

University 1998

3 Genetics -Principles and Analysis Hartl and Jones 5th edition Jones and Barlet

2001

4 Genetics of Populations P W Hedrick 2nd Edition Jones amp Bartlett 2000

5 Principles of Population Genetics Hartl amp Clark Third Edition Sinauer

Associates Inc 1997

BT-504 Bioinformatics-I Laboratory

1 Inter-conversion different sequence file format

2 Database Searching using Entrez and SRS

3 Study of Databases and Data retrieval

4 Dot Matrix Alignments

5 Needleman Wunsch Alignments

6 Smith Waterman Alignments

7 Multiple Sequence Alignment

8 Phylogenetic Analysis

9 Perl Programs

13

Group B

BT-551 Biostatistics

Unit 1

Random variable and Expectation Random variable and distribution function Jointly

distributed random variables Mathematical expectation Statistical parameters Moment

generating function Chebyshevrsquos inequality

Unit 2

Probability Distributions Binomial distributions Multinomial distribution Geometric

distribution Poisson distribution Normal distribution Normal distribution as limiting

case of Binomial distribution Exponential distribution

Unit 3

Correlation and Regression Method of least square and curve fitting Correlation Karl

Pearsonrsquos coefficient of linear correlation Probable error Rank correlation and

Spearmanrsquos coefficient Regression

Unit 4

Sampling distributions and Large sample estimation Sampling plans Statistics and

sampling distributions The central limit theorem The sampling distribution of the

sample mean The sampling distribution of the sample proportion Tests of significance

Large samples testing Sampling of attributes

Unit 5

Exact sampling distributions and small sample test The Chi-square distribution

Studentrsquos t-distribution Snedecorrsquos F- distribution Their Properties and applications

14

Unit 6

ANOVA One - way analysis of variance Two - way analysis of variance Three - way

analysis of variance

Reference Books

1 Pagano M and Gaureau K lsquoPrinciples of Biostatisticsrsquo 7th ed Thomson

Learning2007

2 Ross SM lsquoProbability and Statistics for Engineers and Scientistsrsquo 3rd ed

Academic Press 2005

3 Walpole RE Myers RH MyersSL Ye K lsquoProbability and Statistics for

Engineers and Scientistsrsquo Prentice Hall Inc 2002

4 Taneja HC lsquoStatistical Method for Engineering and Sciencesrsquo IK

Intenational2009

BT-552 High-Throughput Structural Biology

Unit I

Introduction Peptide Bonds hydrogen bonding ionic and hydrophobic interactions

Protein Structure Reverse Turns and Organized Folds Structure Classification Folding

Mechanisms Bond lengths bond angles and torsion angles Degrees of freedom Cyclic

molecules Rotation about a bond Eulerian angles Helices and their notations Analysis

and manipulation of structures Ramachandran plots Chaperones and Chaperonins

Structure Determination Dynamics Simulation Protein Folding Nucleic Acid Structure-

DNARNA Structural Biology for the Optimization of Gene Therapy Vectors Hands-on

assembly of amino acid and nucleotide dimer CPK models

Unit II

X-Ray Crystallography Computing amp NMR Structure Determination X-ray

Crystallography Computing The Phase Problem Least Square Solutions Entropy

Maximization Indirect Methods NMR Structure Determination Nuclear Magnetic

Resonance Distance Geometry Distance-based Modeling Structural Analysis

15

Unit III

Optical spectroscopy Absorbance spectrum and melting of a protein circular

dichroism molecular chirality structural transitions of macromolecules and analysis of

spectral results ligand binding and cell sorting Circular dichroic spectrum and melting

of a protein radiation radioactive decay particle detection liquid scintillation surface

plasmon resonance Thermodynamics of macromolecular transitions Mass spectroscopy

application to complex proteins Diffraction overview crystallization wavevector math

and scattering scattering from a periodic lattice reciprocal space and symmetry

multiwavelength anomalous diffraction and crystallographic statistics

Unit IV

Potential Energy Minimization Potential Energy Function Local Optimization Global

Optimization Energy Transformation

Unit V

Molecular Dynamics Simulation Equations of Motion Initial-Value Problem

Boundary-Value Problem Normal Mode Analysis

Unit VI

Knowledge-based Protein Modelling SequenceStructural Alignment Fold

RecognitionInverse Folding Knowledge-based Structural Refinement Structural

Computing Comparative and ab initio modelling

Reference Books

1 Principles of Biochemistry D L Nelson and MM Cox Lehninger W H

Freeman Fourth Edition 2004

2 Structural Genomics and High-Throughput Structural Biology Michael

Sundstroumlm Martin Norin Aled Edwards CRC Press 2006

3 The Physical Basis of Biochemistry The Foundations of Molecular Biophysics

PR Bergethon Springer Corrected edition 2000

16

4 Principles of Physical Biochemistry KE van Holde CJohnson and PShing Ho

Prentice Hall Second edition 2005

5 Lecture Notes on Computational Structural Biology Zhijun Wu World Scientific

Publishing Co Pte Ltd 2008

BT-553 High-Throughput Structural Biology Laboratory

1 Chemical modification of proteins

2 Peptide mapping

3 Analysis of amino acid composition

4 Analysis and interpretation of spectrophotometric data for denaturation studies

5 Analysis of CD data

6 Analysis and interpretation of NMR data

7 Crystallization of Lysozyme ndash pH driven and salt driven crystallization Effect of

concentration BMCD

8 Analysis and interpretation of X-Ray crystallographic data

9 Public domain software for structure modeling and visualization

BT -554 Self Study Open Area Seminar

17

Semester II

Group C

BT-601 Bioinformatics II

Unit I

Human Genetic Variation Databases of human genetic variation SNP databases

Mutation databases Tools for SNP and mutation visualization

Unit II

Biological Sequence Analysis amp Characterization Predictive Functional Analysis of

coding and non-polymorphisms Amino Acid Properties and Consequences of

Substitutions

Unit III

Genotype-Phenotype Mapping Relationship between genotypes and phenotypes

Genetic programming and its influence on phenotypes Monogenic and complex

disorders Interplay of genetic and environmental factors Integration of clinical and

molecular data Understanding the factors influencing disease susceptibility

Unit IV

Soft computation Machine learning Supervised and Unsupervised Methods Artificial

Neural Networks support vector machines fuzzy logic applications to data mining and

bioinformatics

18

Unit V

Pharmacogenomics and Pharmacogenetics Introduction Pharmacogenetics Drug

Response Single Nucleotide Polymorphism Case Study Pharmacogenomics Databases

OpenPGx Consortium

Unit VI

Bioinformatics Applications and Case Studies Novel Data Annotation and Curation

Pharmacogenomics Applications Database Creation Development of a Predictive Tool

Reference Books

1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves

Noah Hardy ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd

2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS ISBN978-

81-8318minus831minus9 Himalaya Publication House

3 Discovering Genomics Proteomics and Bioinformatics Campbell

ISBN978813171 5598 Pearson Education

4 Proteomics Theory and Practice Gomase VS and Chikhale NJ Himalaya

Publication House

5 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978-3-

527-30541-4 John Wiley amp Sons India Pte Ltd

BT-602 Professional Elective I

BT-6021 Biological Database Management

Unit I

Introduction to Database Systems Overview File Systems vs DBMS Advantages of

DBMS Describing and Storing Data in DBMS Queries in a DBMS Structure of a

DBMS Exercises

19

Unit II

Relational Databases for Bioinformatics Relational Queries Relational Algebra amp

Calculus SQL Queries Programming amp Triggers Query by Example From relational

algebra to SQL

Unit III

Data Storage and Indexing File Organizations amp Indexes Tree-Structured amp Hash-

Based Indexing

Unit IV

Introduction to biological databases Nucleic acid and protein sequence data banks

GenBank EMBL DDBJ TrEMBL GenPept nucleotide sequence databank cDNA

databanks AIDS Virus sequence data bank rRNA data bank NBRF-PIR SWISSPROT

Signal peptide data bank etc

Unit V

Design of Biological Database System for Bioinformatics Schema Refinement amp

Normal Forms Physical Database Design amp Tuning Database Security amp Access

Control

Unit VI

Advanced DBMS Topics Parallel amp Distributed Databases Internet Databases Data

Mining Object-Database Systems Spatial Data Management

Reference Books

1 Database System Concept By CJ Date

2 Database System By Aho Ullman

3 Database Systems By Rob Coronel

4 Database Management Systems Raghu Ramakrishnan amp Johannes Gehrke

Second Edition

20

5 Database Modeling and Design Logical Design Toby J Teorey Sam S

Lightstone Tom Nadeau Publisher Morgan Kaufmann 4th Edition 2005

BT-6022 Plant Bioinformatics

Unit I

Plant Databases and Resources NCBI MIPS TAIR ArEnsEMBL Legume Maize

and Barley Resources

Unit II

Methods for Analysis of Gene Expression in Plants MPSS Classification of mRNA

Signatures Genomic Database MPSS Expression Database

Unit III

Metabolomics Data Analysis Visualization and Integration GC-MS HPLC-MS and

UPLC-MS Metabolic Profiling Methods

Unit IV

KEGG Bioinformatics Resource for Plant Genomics Research Pathway Maps

SSDB EXPRESSSION BRITE LIGAND GENOME

Unit V

Automated Discovery of Single Nucleotide Polymorphism and Simple Sequence

Repeat Molecular Genetic Markers SSR Discovery SNP Discovery SSRPrimer

SNPServer

Unit VI

Methods for Gene Ontology Annotation Web Sites for Browsing GO GO

Annotations Manual Annotations Computational Annotation Methods Functional

Analysis of Datasets

21

References

1 Plant Genomics Methods and Protocols Daryl J Somers Peter Langridge and J

Perry Gustafson Humana Press 2009

2 Plant Bioinformatics Methods and Protocols David Edwards Humana Press

2007

3 Biotechnology in Agriculture and Forestry Plant Metabolomics K Saito RA

Dixon and LWillmitzer Springer-Verlag Berlin Heidelberg 2006

4 Plant Genomics and Proteomics CHRISTOPHER A CULLIS John Wiley amp

Sons Inc 2004

5 Data Mining for Genomics and Proteomics Darius M Dziuda John Wiley amp

Sons Inc 2010

BT -6023 Web Application Development

Unit I

Perl Programming

Introduction and Installation

Unit II

Data types Arithmetic and Logical operators Conditionals and Loops List and Arrays

Working with files Regular Expression and Pattern Matching Bioperl installation and

any two related modules

Unit III

MySQL CGI and PHP Installing MySQL MySQL Programs Working with Data

MySQL Privileges

Unit IV

MySQL and Perl Perl DBI Connect Statement Handles Error Handling Server

Admin

22

Unit V

Apache Understanding Apache Installation Configuration

Unit VI

Database Creation using Perl Apache amp MySQL

Reference Books

1 Perl and Apache Adam McDaniel Wiley Publishing Inc 2010

2 Beginning Perl for Bioinformatics James Tisdall OrsquoReilly 1st Edn 2001

3 Developing Web Applications with Apache MySQL memcatched and Perl

Patrick Galbraith Wiley Publishing Inc 2009

4 Beginning Perl Development Steve Suehring Springer-Verlag New York Inc

2006

5 Database Management Systems Raghu Ramakrishnan amp Johannes Gehrke

Second Edition

BT-603 Professional Elective II

BT-6031 Computational Genomics

Unit I

DNA Sequencing Principles of DNA sequencing Pyrosequencing Automated DNA

sequencing Shotgun sequencing ndash contig assembly High through put sequencing

Double Digest Problem DNA double digest problem multiple solutions to double

digest problem Algorithm for DDP- Integer programming Partition problem and

travelling salesman problem probed partial digest problem homometric sets

23

Unit II

Cloning and clone libraries libraries by complete and partial digestion Gene mapping

mapping with unique and non-unique probes optical mapping interval graphs mapping

with restriction fragment fingerprints Lander-Waterman statistics screening clone

libraries radiation hybrid mapping

Unit III

Genome mapping Commonly Used DNA Markers SNPs or single nucleotide

polymorphisms Genetic Mapping and Physical Mapping alternating Eulerian cycles

transformations in Eulerian cycles Radiation maps STS NCBI and Map Integration

NCBIs Map Viewer Human Genome DNA analysis for health care Study of Model

Species

Unit IV

Functional Genomics DNA arrays sequencing by hybridization (SBH) positional

sequencing by hybridization SBH and the shortest superstring problem SBH and the

Eulerian path problem probability of unique sequence rearrangements string

rearrangements design of DNA microarrays fidelity probes for DNA arrays ESTs

Digital Northerns SAGE Relational Data Base cDNA Microarrays Oligonucleotide

Microarray Chips Cancer and Genomic microarrays Examples for application of

Microarrays Microarrays Data Analysis Gene finding tool

Unit V

Gene expression analysis Gene Control in Prokaryotes and Eukaryotes Structural

Motifs in Eukaryotic Transcription Factors Softwares for Motif Finding SAGE

SAGEmap GEO Profiles GEO DataSets GEO BLAST GEO DataSet Cluster Analysis

Gene Expression Data Analysis cDNA ESTs dbEST and Gene expression study

24

Unit VI

Gene prediction

Gene finding composition based finding sequence motif-based finding Finding of ORF

CpG Island Exons-Introns boundaries Splice site Homology Ab initio gene prediction

program Type of Gene prediction methods and algorithms Eukaryotic gene finding

Gene model in most gene finders Promoter Region Transcriptions Factor and Signals

GENSCAN FGENESH FGENES Promoter recognition programs TSSG NSITE

Pattern Search program Motif representation consensus regular expressions PSSMs

Markov models Other features of nucleic acid sequencing Protein motifs amp domains

Reference Books

1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves

Noah Hardy ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd

2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS

ISBN978minus81minus8318minus831minus9 Himalaya Publication House

3 Discovering Genomics Proteomics and Bioinformatics Campbell

ISBN97881317155 98 Pearson Education

4 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978-3-

527- 30541-4 John Wiley amp Sons India Pte Ltd

5 Introduction to Computational Genomics A Case Studies Approach Nello

Cristianini Matthew W Hahn ISBN-139780521671910 Cambridge University

Press India Private Limited

BT-6032 Drug Design and Discovery

Unit I

Drug Discovery Organized Drug discovery and development Source of drugs

Pharmacological Microbial Recombinant Biochemical and Molecular level screening

systems and their construction strategies

25

Unit II

Approaches to New Drug Discovery Alternative strategies in Lead identification Lead

optimization Preclinical development Clinical trials Patenting and clearance for

application

Unit III

Enzymes as Targets of Drug Design Enzyme kinetics Enzyme inhibition and

activation Approaches to the Rational Design of Enzyme Inhibitors Structures of

enzyme stereochemistry of substrate binding site concept of subsites design of substrate

analogs structure based design of inhibitors enzyme inhibitor interactions binding

constant lock and key mechanism induced fit mechanism inhibitors as drug enzyme

inhibitor complexes recognition of new elements in the binding site development of

tight inhibitors Enzyme kinetics Enzyme inhibition and activation Approaches to the

Rational Design of Enzyme Inhibitors

Unit IV

Receptors as Targets of Drug Design Receptor Theory Lead Compound Discovery of

Receptor agonists and antagonists Receptor Complexes and Allosteric Modulators

Molecular Biology of Receptors Receptor Models and Nomenclature Receptor Binding

Assays Lead Compound Discovery of Receptor agonists and antagonists Natural

Product Sources Pharmacophore-based Ligand Libraries Diversity-based ligand

libraries High-throughput screening Receptor versus enzyme mediated drug action SAR

and its quantitative description QSAR Molecular principles in agonist and antagonist

action Thermodynamic and structural principles Objectives and approaches in the native

ligand modification Molecular graphic and dynamical methods in peptide and protein

mimicry Morphinans versus Enkephalins paradigm example of a peptido-mimetic

Other illustrative examples from current literature Drug design by receptor site fit

Active site simulations using PDB structure data and homology modeling Graphical and

computational active site fits exploiting small structure data libraries and commercial

softwares

26

Unit V

Computational Tools and Techniques Homology Model Building Molecular

Mechanics Protein Folding Docking Pharmacophore Models QSAR 3D-QSAR

Quantum Mechanics in Drug Design Cheminformatics

Unit VI

Current status and future prospects Synthetic Peptide libraries Peptide libraries

through Phage Display Applications in Epitope and Agretope mapping and in synth etic

vaccine design Artificial combinatorials Peptides bezodiazepines and other current

examples Selection strategies and screening methodologies Perspectives in Gene

Therapy Human Genome Project and its possible impact Prodrug Design and

Applications

Text Books

1 Comprehensive Medicinal Chemistry C Hansch (Ed) (Vols I-VI) Academic

Press 1990

2 Design of Enzyme Inhibitors as Drugs M Sandler and H J Smith Oxford Univ

Press 1989

3 Drug Discovery and Design Medical Aspects J Matsoukas and T

Mavromoustakos IOS Press 2002

4 Drug Design Cutting Edge Approaches Darren R Flower The Royal Society of

Chemistry Cambridge 2002

5 Protein Folding and Drug Design R A Broglia and L Serrano IOS Press 2007

BT-6033 Chemoinformatics

Unit I

Role of computers in chemical research Introduction to Chemoinformatics

Representation and manipulation of 2D and 3D molecular structures Chemical Databases

- Design Storage amp Retrieval methods

27

Unit 2

Representation of Molecules and Chemical compounds and reactions Different types of

Notations SMILES Coding Structure of Mol files and Sd files( Molecular converter

SMILES Translator)Similarity search of the molecule (Zinc Database)

Unit 3

Reaction databases Representation of chemical reactions Search techniques (Full Sub

and Super structure) Similarity searches Modeling of small molecules

Unit 4

Virtual screening and compound filtering biologically active compounds virtual and

high throughput screening filter functions

Unit 5

Combinatorial chemistry and Library design -Introduction Diversed and focused

Libraries Combinatorial library design strategies Product-based library design Multi-

objective library design

Unit 6

Analysis of high-throughput screening data- Introduction Data visualization Data

mining methods Prediction of ADMET properties QSAR Analysis model building and

model evaluation Chemoinformatics tools for drug discovery

Reference Books

1 Chemoinformatics theory practice amp products by Bary A Bunin Springer

2 Chemoinformaticsa textbook by Johann Gasteiger Wiley

3 Methods in molecular biology volume 201 Combinatorial library methods and

protocol edited by Lisa Bellavance English Humana Press

4 An introduction to chemoinformatics by Andrew R Leach Valerie J Gillet

Kluwer Academic Publishers

28

BT -604 Bioinformatics-II Laboratory

1 SNP and Mutation Databases

2 Gene Ontology

3 Predictive Functional Analysis of SNPs ndash SIFT PolyPhen

4 Pharmacogenomics Databases

BT-651 Professional Elective III

BT-6511 Computer Aided Drug Design

Unit I

Introduction Introduction to CADD SBDD Representation of Molecular Structures

Chemical Nomenclature and Structure Representation Processing Constitutional

Information Representation of 3D Structures Molecular Shape Analysis Representation

of Chemical Reactions

Unit II

Virtual Screening Virtual Screening Chemoinformatics in Lead Discovery

Computational Chemistry Molecular Complexity and Screening Set Design Algorithmic

Engines in Virtual Screening Strengths and Limitations of Pharmacophore-Based Virtual

Screening

Unit III

Lead Discovery High Throughput Screening Hit and Lead Discovery Enhancing Hit

Quality and Diversity within Assay Throughput Constraints Molecular Graphics

Molecular Dynamics and Simulation of Lead Molecular Diversity in Lead Discovery

From Quantity to Quality In Silico Lead Optimization

29

Unit IV

Databases and Libraries Databases and Libraries PubChem PubEchm-BioAssay

Pharma Project Drug Bank WOMBAT World of Molecular Bioactivity Cabinet -

Chemical and Biological Informatics Network Structure Modification in Chemical

Databases Rational Design of GPCR-specific Combinational Libraries Based on the

Concept of Privileged Substructures

Unit V

Molecular docking amp Simulation de novo pharmacophore elucidation drug design for

structurally well-defined receptor targets like HIV protease inhibition ER antagonism

H2 receptor antagonism Chirase inhibition (quinoline derivative antibiotics) and ACE

inhibition macromolecule-ligand docking docking algorithms AUTODOCK Molecular

dynamic simulations relative energy energy minimization methods ligand binding free

energy calculations (both simulation and empirical methods) intermolecular interactions

forces related to drug binding force-field calculation including solvation role of

solubility in drug binding and pKa Poisson-Boltzmann Surface Area (PBSA) AMBER

GROMOS and GROMACS

Unit VI

CADD Applications CADD Applications A Practical Strategy for Directed Compound

Acquisition Efficient Strategies for Lead Optimization Chemoinformatics Tools for

Library Design Hit-to-Lead Process A Users Perspective Application of Predictive

3DQSAR Models to Database Mining Drug Discovery - Case Study

Reference Books

1 Computer Applications in Pharmaceutical Research and Development Wang

Binghe ISBN-10 0-471-73779-8 John Wiley amp Sons India Pte Ltd

2 Engineering Chemistry RV Gadag and A Nityananda Shetty ISBN

8188237833 IK International Publishing House Pvt Ltd

3 Virtual Screening in Drug Discovery Juan Alvarez and Brian Shoichet ISBN-13

978-0824754792 CRC Press

30

4 Biological Thermodynamics Donald T Haynie ISBN9780521704045

Cambridge University Press India Private Limited

5 Chemoinformatics in Drug Discovery Tudor I Oprea Raimund Mannhold Hugo

Kubinyi Gerd Folkers ISBN 978-3-527-30753-1 John Wiley amp Sons India Pt L

BT - 6512 Computer Graphics

Unit I

Graphic Systems Refresh CRT raster-scan displays DVST plasma displays LCD

Unit II

Input devices functions provided by input devices basic working of these input

devices image scanners touch panels Input modes request mode event mode

Unit III

Output Primitives Points lines DDA Bresenham live amp circle drawing algorithm

ellipse generation

Unit IV

Filled area Primitives scan line polygon fill algorithm inside outside tests boundary

fill algorithm Line width color color and gray levels character attributes

Unit V

Two-dimensional Geometric Transformation Basic transformation translation

rotation scaling fixed point scaling general scaling direction The viewing pipeline

window viewpoint transformation Line clipping algorithms

Three Dimensional concepts Polygon surfaces plane equation curved lines and

surfaces quadric surfaces spline representation spline specification Bezier curves and

surfaces B-splines and surfaces Displaying spline curves and surfaces Hornerrsquos rule

31

Three-Dimensional transformation and viewing methods 3 D transformations viewing

co-ordinates transformation from world to viewing co-ordinates parallel and perspective

projections Back face detection depth-buffer and A-buffer methods

Unit VI

3D Object Representation Visible Surface Algorithms Curves and Surfaces in

Computer Graphics Introduction to Ray Tracing and Radiosity methods Anti-aliasing

Shadow generation Texture mapping Effects Fractals Image Coding Color

Reference Books

1 Computer Graphics by DHearn and MP Baker

2 Computer Graphics - A programming approach by Harriyton

3 Procedural Elements of Computer Graphics by Roger

4 Three Dimensional Computer Graphics by Folley and Dam

5 Computer Graphics Principles and Practice James Foley Andries van Dam

Steve Feiner and John Hugues Second Edition

BT-6513 Pharmacogenomics and Personalized Medicine

Unit I

Introduction to Pharmacogenomics The roots of pharmacogenomics Historical

Perspectives and Current Status

Unit II

The Human genome Computational genome analysis

Unit III

Functional Analysis of Gene Variation amp Genotyping Techniques Aspects

influencing method of selection SNP Genotyping TaqMan Genotyping

32

Unit IV

Pharmacogenomics in drug discovery The need of protein structure information

protein structure and variation in drug targets-the scale of problem Mutation of drug

targets leading to change in the ligand binding pocket

Unit V

Case Studies

Unit VI

Management of Pharmacogenomic Information PharmGKB

Reference Books

1 Pharmacogenomics The Search for the Individualized Therapiesrdquo Licinio Julio

and Ma-Li Wong Wiley-VCH 2002

2 Pharmacogenomics An Approach to New Drugs Development Chakrabarthy

Chiranjib and Bhattacharyya Atane 2004

3 Pharmacogenomics Social Ethical and Clinical Dimensions Rothstein Mark A

Wiley-Liss 2003

4 Pharmacogenomics in Drug Discovery amp Development Qing Yan Humana

Press 2008

5 Pharmacogenomics Methods and Protocols Federico Innocenti Humana Press

2005

BT-652 Professional Elective IV

BT -6521 Combinatorial Methods in Biopharamaceuticals

Unit I

Introduction The Original Combinatorial Chemist ndash Biopolymers constitute natural

libraries ndash Selection and evolution ndash The expression of genetic information

33

Combinatorial assembly of antibody genes ndash Molecular solutions to Combinatorial

problems

Unit II

Synthetic Peptide Libraries Solid-Phase peptide synthesis ndash Peptide on pins ndash Other

iterative disconvolution strategies Examples of SplitCoupleMix Peptide Libraries ndash

Positional Scanning

Unit III

Supports Linkers and Reagents for peptide and small molecule synthesis

Polystyrenes ndash PEG ndash Grafted supports ndash Coupling strategies ndash New resins and linkers ndash

Ring ndash forming cleavage ndash loading

Unit IV

Supported Solution ndash Phase Synthesis Polyethylene glycols ndash Dendrimers Fluorous

synthesis ndash Solution ndash Phase parallel synthesis scavenging resins ndash Ion Exchange resins ndash

Supported reagents ndash Flourous reagents ndash Solid phase extraction ndash Gas Phase separation

Unit V

Analytical Methods for Solid-Phase Synthesis Product identification ndash Gel Phase

NMR ndash High resolution magic angle spinning NMR on-bead infrared Spectroscopy ndash

Mass Spectroscopy ndash Non-Spectroscopic Methods- Product identification ndash Gel Phase

NMR ndash High resolution magic angle spinning NMR on-bead infrared Spectroscopy ndash

Mass Spectroscopy ndash Non Spectroscopic Methods

Unit VI

A Combinatorial Approach to Gene Expression Analysis DNA Microarrays DNA

Microarray Components Characteristics and Technology Fabrication Target

Preparation and Labelling Procedures Hybridization and Washing Target Detection

Analysis Applications of the Microarray Technology

34

Reference Books

1 Fenniri Hicham lsquoCombinatorial Chemistryrsquo Oxford University Press 2000

2 Block JH and Beale JM lsquoWilson amp Gisvolds Text book of Organic Medicinal

and Pharmaceutical Chemistryrsquo 11th Edition Lippincott Williams amp Wilkins

2004

3 Fassina G ldquoCombinatorial Chemistry and Technologies Methods and

Applicationsrdquo 2nd Edition CRC Press 2005

4 Combinatorial Chemistry Synthesis Analysis Screening Gunther Jung

WILEY-VCH Verlag GmbH 2001

5 Handbook of Combinatorial Chemistry Drugs Catalysts Materials K C

Nicolaou Wiley-VCH 2002

BT -6522 Data Warehousing and Data Mining

Unit I

Data Warehousing and Business Analysis Data warehousing Components ndashBuilding a

Data warehouse ndash Mapping the Data Warehouse to a Multiprocessor Architecture ndash

DBMS Schemas for Decision Support ndash Data Extraction Cleanup and Transformation

Tools ndash Metadata ndash reporting ndash Query tools and Applications ndash Online Analytical

Processing (OLAP) ndash OLAP and Multidimensional Data Analysis

Unit II

Data Mining Data Mining Functionalities ndash Data Preprocessing ndash Data Cleaning ndash Data

Integration and Transformation ndash Data Reduction ndash Data Discretization and Concept

Hierarchy Generation

Unit III

Association Rule Mining Efficient and Scalable Frequent Item set Mining Methods ndash

Mining Various Kinds of Association Rules ndash Association Mining to Correlation

Analysis ndash Constraint-Based Association Mining

35

Unit IV

Classification and Prediction Issues Regarding Classification and Prediction ndash

Classification by Decision Tree Introduction ndash Bayesian Classification ndash Rule Based

Classification ndash Classification by Back propagation ndash Support Vector Machines ndash

Associative Classification ndash Lazy Learners ndash Other Classification Methods ndash Prediction ndash

Accuracy and Error Measures ndash Evaluating the Accuracy of a Classifier or Predictor ndash

Ensemble Methods ndash Model Section Cluster Analysis - Types of Data in Cluster

Analysis ndash A Categorization of Major Clustering Methods ndash Partitioning Methods ndash

Hierarchical methods ndash Density-Based Methods ndash Grid-Based Methods ndash Model-Based

Clustering Methods ndash Clustering High-Dimensional Data ndash Constraint-Based Cluster

Analysis ndash Outlier Analysis Mining Object Spatial Multimedia Text and Web Data

Multidimensional Analysis and Descriptive Mining of Complex Data Objects ndash Spatial

Data Mining ndash Multimedia Data Mining ndash Text Mining ndash Mining the World Wide Web

Unit V

Microarray Data Mining Practical Factors Prior to Data Mining Differential Gene

Expression Discriminant Analysis Gene Annotation and Pathway Analysis Microarray

Data Mining Applications

Unit VI

Integrative Data Analysis for Biological Discovery Introduction Representative

Selection of Algorithms Application to a specific domain Future trends

Reference Books

1 Jiawei Han and Micheline Kamber ldquoData Mining Concepts and Techniquesrdquo

Second Edition Elsevier Reprinted 2008

2 Alex Berson and Stephen J Smith ldquoData Warehousing Data Mining amp OLAPrdquo

Tata McGraw ndash Hill Edition Tenth Reprint 2007

3 KP Soman Shyam Diwakar and V Ajay ldquoInsight into Data mining Theory and

Practicerdquo Easter Economy Edition Prentice Hall of India 2006

4 G K Gupta ldquoIntroduction to Data Mining with Case Studiesrdquo Easter Economy

36

Edition Prentice Hall of India 2006

5 Pang-Ning Tan Michael Steinbach and Vipin Kumar ldquoIntroduction to Data

Miningrdquo Pearson Education 2007

BT-6523 Genomics From Human Genome Project to Medical

Applications

Unit I

Biotechnology and Genomics in Medicine Gene Medicine Disease Models Impact of

Genomics on Medicine Molecular Medicines

Unit II

Genomics Human Genome Project Breakthroughs Functional Genomics Comparative

Genomics Transcriptomics Proteomics Mutational Genomics

Unit III

Genomics Applications in Infectious Diseases Identification of causative microbes

molecular epidemiology host resistance to infection pathogenicity combating infectious

diseases

Unit IV

Genomics Applications in Genetic Diseases Genetic Disorders detection and treatment

of single gene disorders analysis of polygenic disorders linkage analysis Linkage

disequilibrium mapping haplotypes MHC pharmacogenomics

Unit V

Genomics Applications in Cancer Molecular basis of cancer impact of genomics on

cancer research methods for the diagnosis of cancer approaches to cancer therapy

37

Unit VI

Case Study Cardiovascular Disorders Cardiovascular Single Gene Disorders

Cardiovascular Polygenic Disorders Therapies and Applications

Reference Books

1 Human Molecular Genetics Third Edition (2003) T Strachan and AP Read

Garland Science Publication

2 Molecular Cell Biology Sixth Edition (2007) H Lodish A Berk and CA

Kaiser W H Freeman amp Co Ltd

3 Cardiovascular Genetics and Genomics for the Cardiologist (2007) Victor J Dzau

and Choong-Chin Liew Blackwell Publishing

4 Genomics The Science of Technology Behind the Human Genome Project

(1999) Charles R Cantor and Cassandra L Smith John Wiley amp Sons Inc

5 A Century of Mendelism in Human Genetics (2005) Milo Keynes

AWFEdwards and Robert Peel CRC Press

BT-653 Professional Elective-III Laboratory

BT-6531 Computer-Aided Drug Design Laboratory

1 To perform the homology modeling of a protein by using the MODELLER

software

2 To evaluate the 3D structure of a protein by using the different tools on the SAVS

server

3 To find the active sitecavity in a receptor by using the SURFACE RACER

program

4 To draw the chemical structures by using the ChemSketchChemDraw software

5 To perform the de novo Drug Designing by using the LIGBUILDER software

6 To perform the protein-ligand docking by using the HEX program

7 To perform the protein-protein docking by using the AUTOCOCK software

38

8 To perform the virtual screening of ligands by using the DOCK program

9 To perform the Quantitative Structure-Activity Relationship (QSAR) analysis by

using the DRAGON software

10 To perform the Pharmacophore modeling of ligands by using the LigandScout

program

BT-6532 Computer Graphics Laboratory

1 Standard functions in the c graphics module -Introduction to pixels drawing

various geometric objects filling polygons images etc

2 Implementation of the basic line drawing algorithm and the Circle drawing

algorithm using DDA Midpoint algorithm Bresenhams algorithm etc

3 Polygon filling using seed fill scan line algorithm etc

4 Clipping algorithms -Cohen-Sutherland algorithm LiangBarsky algorithm etc

5 2D and 3D Transformations -Translation scaling rotation etc

6 Projections - Parallel and perspective projections and their types Curve fitting -

Cubic curves (Bezier curves spline curves etc)

7 Lighting and Shading -Implementing Phong illumination model Gouraud and

Phong shading Animation

8 Image processing demonstration

BT-6533 Pharmacogenomics and Personalized Medicine

Laboratory

1 Accessing querying and becoming comfortable with the interface of

pharmacogenomics based databases ndash

a UCSC

b NCBI dbSNP

c HapMap and resequencing databases

d 1000 Genomes

39

e PharmGKB - a publicly available Internet tool to aid researchers in

understanding how genetic variation among individuals contributes to

differences in reactions to drugs

f Drug Bank

2 Use of PGx pipeline 10 Server

3 Statistical data management using SAS

a Data Collection and Entry

b Data Storage and Transferal

c Data Analysis

d Data Exposition USING sas

4 Understand and run Warfarin dosing algorithm using web based interfaces

5 Sequence variation analysis

BT-654 Minor Project-I

BT-701 Professional Elective V

BT-7011 Immunoinformatics

Unit I

Immunology Introduction Overview of the Immune System A Case Study

Classification of Immunity Concepts in Immunology Antigens Antibodies The

Compliment System Antigen-Antibody Reactions The Major Histocompatibility

Complex allele selection Antigen Presentation TAP T cell receptors

Unit II

Advanced Immunology Immune Effector Mechanisms Cytokines and Chemokines

Hypersensitive Reactions The Immune system in Health and Disease Autoimmunity

Transplantation Immunology Classification of Vaccine

40

Unit III

HLA System in model organism Defining HLA Supertypes in HLAndashStructural and

Modeling Principles HLA Super types by GRIDCPCA and Hierarchical Clustering

Methods Structural Basis for HLA-A2 Supertypes Clustering of MHC Peptide-Binding

Repertoires HLA Alleles-Electrostatic Distribution Maps

Unit IV

In Silico Prediction of Immunogenicity Databases Searching An Introduction

MHCDB(NCBI) IMGT The IMGTHLA Database IPD The Immuno Polymorphism

Database SYFPEITHI Database for Searching and T-Cell Epitope Prediction Mapping

of T-Cell Epitopes MHC Binders and TAP Binders Mapping of LinearB-Cell Epitopes

in Bcipep Database Haptens Carrier Proteins and Anti-Hapten Antibodies

Unit V

Predictions Predicting Peptide-MHC Binding PeptidendashMHC Binding Using Profiles

Machine Learning Techniques for MHC Binders Artificial Intelligence Methods for

Predicting T-Cell Epitopes MHC-Class I and II Binding Affinity MHCndash Molecular

Affinity and QSAR Models Support Vector Machine for MHC-Binding Peptides Static

Energy Analysis of MHC Class I and Class II Peptide-Binding Affinity Nonlinear

Predictive Modeling of MHC Class IIndashPeptide Binding Using Bayesian Neural

Networks

Unit VI

Applications Computational vaccinology Viral Bioinformatics Immunogenomics

Mathematical models of HIV and the immune systems

Reference Books

1 Immunology Richard A Goldsby Thomas J Kindt Barbara A Osborne Janis

Kuby WH Freeman amp Company 5th edition Pages 19-504 2003

41

2 Roittrsquos Essential Immunology Ivan M Roitt Peter J Delves Blackwell Science

Ltd 10th Edition 2001

3 Immunoinformatics predicting Immunogenicity in-silico Darren R Flower

Humana Press Pages 1-309

4 Instant Notes in Immunology PM Lydyard A Whelan MW Fanger BIOS

Scientific Publishers Ltd 1st Edition 2003

5 An Introduction to Immunology CV Rao Narosa Publishing House1st Edition

2004

BT-7012 Medical Bioinformatics

Unit I

An Overview Introduction Problems in health care motivating biomedical informatics

Seminal documents and reports Resources of field - organizations information

education

Biomedical Computing Types of Computers Data Storage in Computers Computer

Hardware and Software Computer Networks Software Engineering Challenges for

Biomedical Computing

Electronic Health Records Clinical Data and Workflow History and Perspective of the

Health (Medical) Record Potential Benefits of the Electronic Health Record

Definitions and Key Attributes of the EHR EHR Examples Nursing Informatics

Unit II

Clinical Decision Support EHR Implementation Historical Perspectives and

Approaches Medical Errors and Patient Safety Reminders and Alerts Computerized

Provider Order Entry (CPOE) Implementing the EHR Use and Outcomes of the EHR

Cost-Benefit of the EHR

Standards and Interoperability Privacy Confidentiality and Security Standards

Basic Concepts Identifier and Transaction Standards Message Exchange Standards

42

Terminology Standards Privacy Confidentiality and Security Basic Concepts HIPAA

and Other Countriesrsquo Privacy and Security Regulations

Unit III

Secondary Use of Clinical Data Personal Health Records Health Info Exchange

Public Health Health Care Quality Clinical Research Personal Health Records Health

Information Exchange Public Health Informatics Health Care Quality Clinical Research

Informatics

Unit IV

Evidence-Based Medicine and Medical Decision Making Definitions and Application

of EBM Interventions Diagnosis Harm and Prognosis Summarizing Evidence Putting

Evidence into Practice Limitations of EBM

Unit V

Information Retrieval and Digital Libraries Information Retrieval Knowledge-based

Information Content Indexing Retrieval Evaluation Digital Libraries

Imaging Informatics and Telemedicine Imaging in Health Care Modalities of

Imaging Digital Imaging Telemedicine Definitions and Barriers Efficacy of

Telemedicine

Unit VI

Translational Bioinformatics Translational Bioinformatics - The Big Picture

Overview of Basic Molecular Biology Important Biotechnologies Driving

Bioinformatics Genetics-Related Diseases Bioinformatics Information Resources

Translational Bioinformatics Challenges and Opportunities

Organizational and Management Issues in Informatics Organizational Behavior

Organizational Issues in Failure and Success of Informatics Projects Change

Management

43

Reference Books

1 Handbook of Medical Informatics Jvan Bemmel (Editor) MA Musen (Editor)

Mark Musen (Author) Springer-Verlag published

2 Clinical Decision Support Systems Theory and Practice (Health Informatics) by

Eta S Berner (Editor) M J Ball (Editor) Springer-Verlag New York Inc

3 Computer-Based Patient Record An Essential Technology for Health Care

Revised Edition by Committee on Improving the Patient Record Institute of

Medicine Richard S Dick and Elaine B Steen (Paperback - Jan 1997)

BT-7013 Advanced Genetic Engineering

Unit I

Core techniques in gene manipulation Cutting and joining DNA introduction of DNA

into cells Isolation sequencing and synthesis of gene

Unit II

Cloning strategies construction of genomic libraries and cDNA libraries Probe

construction recombinant selection and screening Analysis of expression Analysis of

recombinant DNA site-directed mutagenesis altered expression and engineering genes

Unit III

DNA amplification using polymerase chain reaction Key concepts Analysis of amplified

products Applications of PCR Ligase chain reaction Expression systems and their

applications Ecoli Streptomyces Yeast Baculovirus and animal cells as cloning hosts

Sequencing methods

Unit IV

Transfection techniques Gene silencing techniques Gene knockouts and gene therapy

Differential gene expression and protein array Protein-protein interactions DNA-Protein

44

interactions Somatic and germ line therapy-in vivo and ex vivo Transgenics

Unit V

Applications of Genetic Engineering Pharming Genetically Engineered Foods

Biofuels Designer Babies

Unit VI

Applications of Bioinformatics in Genetic Engineering Functional Genomics

Analysis of Mutations Applications in Agriculture

Reference Books

1 Principles of gene manipulation by RNOld amp SBPrimrose (1994) Blackwell

Scientific Publications

2 DNA cloning I amp II by DM Glover amp BD Hames (1995) IRL Press

3 PCR stratagies by MA Innis DHGelfand amp JJ Sninskey (1995) Academic Press

4 Concepts in Biotechnology ndash Editors DBalasubramanian et al University Press

(1996)

5 Methods in Molecular Biology vol62 Edited by RSTuan Humana Press

Totowa New Jersey

BT-702 Professional Elective VI

BT-7021 Nanotechnology in Health Care

Unit I

Nanotechnology in Pharmaceutical Applications Human anatomy ndash Form function

and physiology ndash Developmental prolog - principle of development ndash Neurophysiology ndash

sensory physiology and muscle physiology - Trends in nanobiotechnology - Protein- and

45

peptide-based compounds for cancer diabetes infectious diseases and organ transplant-

therapeutic classes- focused pharmaceutical delivery systems

Unit II

Immunoassay Techniques Understanding of antibody-based diagnostic techniques

(immunoassay) - micro- and nano-immunosensors- Bio-Barcode Assay- use of magnets

gold DNA and antibodies- therapies and diagnostics for cancer and central nervous

system disorders

Unit III

Improved Medical Diagnostics Improved diagnostic products and techniques- in vivo

imaging capabilities by enabling the detection of tumors plaque genetic defects and

other disease states-ability to control or manipulate on the atomic scale- Nanobot medical

devices- logic and intelligence embedded into medical devices- standalone sensing and

computing devices

Unit IV

Prosthetic and Medical Plants New generations of prosthetic and medical implants-

artificial organs and implants- artificial scaffolds or biosynthetic coatings-

biocompatibility and reduced rejection ratio- retinal cochlear and neural implants

repair of damaged nerve cells and replacements of damaged skin tissue or bone

Unit V

Methods for Diagnosis Animation of the PCR - DNA Profiling - Cantilever Sensors -

Targeted Drug Delivery - Magnetic Nanoparticles - Cancer cell targeting - Stem Cell

Scaffolds - Electrochemical Impedance Spectroscopy (EIS) - Tethered Lipid Membranes

Reference Books

1 Chemical Sensors and Biosensors Brian R Eggins Wiley New York

Chichester 2002

46

2 Biosensors and modern biospecific analytical techniques Wilson amp Wilsonrsquos

Comprehensive Analytical Chemistry Ed L Gorton Elsevier Amsterdam

London 2005

3 The Immunoassay Handbook Ed David Wild 3rd ed Amsterdam Elsevier

2005

4 Electrochemical Methods Fundamentals and Applications Allen J Bard and

Larry R Faulkner Wiley New York Chichester 2nd ed 2001

5 Ultrathin Electrochemical Chemo- and Biosensors Technology and Performance

in Springer Series on Chemical Sensors and Biosensors Volume Two Ed

Vladimir M Mirsky Springer Berlin 2004

BT-7022 Resource Planning amp Management in Bioinformatics

Unit I

Introduction Fundamentals of Resource management practice

Unit II

Bioinformatics resources-an Introduction Tour to bioinformatics web sites Biological

databases and software an overview Open source movement Bioinformatics Resource

utilization and commercialization Networking and Super Computing resources- world

wide and India specific facilities Clinical applications of bioinformatics

Bioinformatics resource management the key-issues (piracy hacking and data mining)

Data Security and integration in Pharma Industry tools and techniques

Unit III

Bioinformatics Resources as a business practice The bioinformatics market-

Bioinformatics companies and products commercialization of bioinformaticsrsquo resources

funding agencies for bioinformatics projects models of technology transfer amp licensing

47

Unit IV

Commercial amp Financial aspects of Bioinformatics Concepts of software product

Market and process economics Financial appraisal of bioinformatics projects - cash flow

diagram ROR discounted ROR etc Architecture of a typical bioinformatics business

plan

Unit V

TRIPS agreement IPR issues in relation to software products processes Architecture

of Patent application Biotechnology amp Bioinformatics Related issues of Public Concern -

Bioethics

Reference Books

1 ERP Demystified Alexis Leon Tata McGraw Hill 1999

2 Concepts in Enterprise Resource Planning Joseph A Brady Ellen F Monk Bret

J Wangner Thomson Learning 2001

3 BAREACT Indian Patent Act 1970 Acts amp Rules Universal Law Publishing

Co Pvt Ltd 2007

4 Kankanala C Genetic Patent Law amp Strategy 1st Edition Manupatra

Information Solution Pvt Ltd 2007

5 Essentials of Management by H Koontz H Weihrich and C OrsquoDonnell

Publisher McGraw-HillIrwin

6 The Practice of Management by P Drucker Publisher Harper Business

BT-7023 Advanced Drug Delivery Systems

Unit I

Dendrimers- Synthesis -Nanoscale containers- Gene transfection ndash Nanosca foldsystems-

Biocompatibility of Dendromers

Unit II

Microfabricated drug delivery systems ndash Microneedles- Micropumps-Microvalves-

48

Implantable microchips ndash sustained chronic disease

Unit III

Properties of drug targeting delivery systems-ADME hypothesis- site specific drugs-

Synthetic carrier for drugs-liposomes-Antibodies

Unit IV

Targeted Nanoparticles for drug delivery- Polymers nanotubes- Issues for specific disease

will be addressed

Unit V

Virus Based Nanoparticles - Modification by bioconjugation ndash Tumour targetting invivo

ndash use in biomedical Imaging

Reference Books

1 Drug Delivery Engineering Principles for Drug Therapy M Salzman Oxford

University Press 2001

2 Drug Delivery and Targeting AM Hillery CRC Press 2002

3 Drug Delivery Principles and Applications B Wang Wiley Intersceince 2005

BT-703 Minor Project ndash II

BT-704 Major Project - I

BT-705 Self Study

BT-801 Major Project-II

1

Delhi Technological University

Civil Engineering Department

M Tech Syllabus

Various Courses of M Tech (Structure) Programmes in Delhi Technological University

Scheme for M Tech (Structural Engineering) Sem Gp Course Details Course

Code L T P Internal

Marks External Marks

Total Marks

Credits

Ist A Advanced Mathematics amp Numerical Techniques

CE501 3 0 0 50 100 150 3

Finite Element Method of Structural Analysis

CE503 3 0 0 50 100 150 3

Advanced Theory of Structures CE502 3 0 0 50 100 150 3 Structural Engg Laboratory CE504 0 0 2 30 70 100 2

B Theory of Plates amp Elastic Stability CE551 3 0 0 50 100 150 3 Theory of Elasticity amp Plasticity CE552 3 0 0 50 100 150 3 CADD Laboratory CE553 0 0 2 30 70 100 2 Self study Open Area Seminar CE554 0 0 2 50 00 50 1

21Hoursweek 1000 20 IInd C

Structural Dynamics CE601

3 0 0 50 100 150 3

Elective I any one of the following 1 Material Science amp Technology 2 Plastic Analysis of Metallic Styructures 3 Stress Analysis

CE6021 CE6022

CE6023

3 0 0 50 100 150 3

Elective II any one of the following 1 Design of Industrial Structures and

Bridges 2 Design of Tall Buildings 3 Seismic Design of Structures

CE6031

CE6032 CE6033

3 0 0 50 100 150 3

Photo-Elasticity Lab CE564 0 0 2 30 70 100 2 D Elective III any one of the following

1 Design of Structures for Dynamic Loads

2 Prestressed Concrete Design 3 Shells and Folded Plates

CE6511

CE6512 CE6513

3 0 0 50 100 150 3

Elective IV any one of the following 1 Design of Hydraulic Structures 2 Groundwater and Seepage 3 Instrumentation 4 Planning and Design of

Environmental Services

CE6521 CE6522 CE6523 CE6524

3 0 0 50 100 150 3

Str Dynamics Lab CE653 0 0 2 30 70 100 2 Minor Project I CE654 0 0 2 50 00 50 1

21Hoursweek 1000 20 IIIrd E Elective V any one of the following

1 Geotechnical Earthquake Engineering

2 Foundation Engineering 3 Soil Structure Interaction

CE7011

CE7012 CE7013

3 0 0 50 100 150 3

Elective VI any one of the following 1 Advanced Building Construction and

CE7021

3 0 0 50 100 150 3

2

Management 2 Disaster Resistant Structures 3 Soil Dynamics and Geotechnical

Earthquake Engineering

CE7022 CE7023

Self Study open area seminar II CE703 0 0 2 50 00 50 1 Minor Project II CE704 0 0 4 00 200 200 4 Major Project part I CE705 0 0 2 200 00 200 4

18Hoursweek 750 15 IVth F Major Project Part II CE801 3 0 0 00 750 750 15 6Hrswk 750 15 Grand Total 3500 70

Subject Code Subject L T P D MM

CE501 ADVANCED MATHEMATICS AND NUMERICAL TECHNIQUES

3 0 0 0

ADVANCED MATHEMATICS AND NUMERICAL TECHNIQUES Determinants and matrices Solution of linear equations Indeterminacy of structures Influence co-efficient methods Flexibility and Stiffness matrices for statically indeterminate structures Application of Fourier series to beams Complex variables Conformal mapping and Schwartz-Christoffel transformation applied to flow problems Tensor analysis (Cartesian) and its application to simple elastic and plastic problems Differential equations Series solution Bessel functions Legendre Polynomials Partial Differential equations Legendrersquos form Numerical method Finite Differences Numerical integration and differentiation Numerical solution of ordinary differential equations and their application to engineering structures Poissonrsquos Laplacersquos and biharmonic equations Relaxation methods and their application to Civil Engineering problems Advanced Computer programming and its application to Engineering problems

References

BSGrawalrdquo Higher engineering mathematicsrdquo

Jain and lyengar ldquoAdvanced engineering mathematicsrdquo Narosa publishing house

EKreyszig ldquoAdvanced engineering mathematicsrdquo John Wiley amp Sons

Peter OrsquoNeil ldquoAdvanced engineering mathematicsrdquo

Subject Code Subject L T P D MM

CE503 FINITE ELEMENT METHOD OF STRUCTURAL ANALYSIS

3 0 0 0

FINITE ELEMENT METHOD OF STRUCTURAL ANALYSIS

Finite element displacement approach plane stress and plane strain problems Triangular and rectangular elements 2-D and 3-D elements Iso-parametric elements Application to structural problems References

CSKrishnamoorthy Finite element analysis theory and programming Tata McGraw Hill Cook RD Malkus DS and Plesha ME Concepts and Applications of Finite Element Analysis Third Edition John Wiley 1989 OC Zienkiewicz The Finite Element Method McGraw-Hill

KJBathe rdquo Finite Element procedures in Engineering Analysisrdquo Prantice Hall India

3

Abel amp DesairdquoIntroduction to the Finite Element Methodrdquo CBS Publishers

Subject Code Subject L T P D MM

CE502 ADVANCED THEORY OF STRUCTURES 3 0 0 0

ADVANCED THEORY OF STRUCTURES

Flexibility and stiffness methods of structural analysis Analysis using substructure technique effects of axial forces on flexural stiffness Analysis of framed shear wall buildings Non Linear and Elasto-Plastic Analysis Beams curved in plan and elevation Various types of structural systems for tall buildings References

HCMartin Introduction to Matrix Methods of Structural Analysis

Kardestuncer Elementary Matrix Analysis of Structures

Weaver amp Gere Matrix Structural Analysis CBS Publisher

AGahali AM Neville amp Brown ldquoStructural analysisrdquo

Norris Wilbur Utku ldquo Elementry Structural analysisrdquo

BeaufaitRowanHoadley ldquoComputer method of Structural analysis

Subject Code Subject L T P D MM

CE504 STRUCTURAL ENGINEERING LABORATOR 0 0 2 0

Structural Engineering Laboratory

Concrete mix design amp testing Non destructive testing of Concrete testing of RCC Under and Over reinforced Beams Columns under eccentric loading two way reinforced RCC Slabs fracture characteristics of mild steel and cold worked steels

Subject Code Subject L T P D MM

CE551 THEORY OF PLATES AND ELASTIC

STABILITY

3 0 0 0

THEORY OF PLATES AND ELASTIC STABILITY Theory of stability The concept of stability Post buckling behaviour of long slender columns Columns with elastically supported ends Newmarkrsquos formula Columns with spring supports two hinged and fixed portal frames symmetrically loaded Energy and numerical methods of columns Columns with lateral loads Columns with variable sections Effect of shearing force on critical load Inelastic buckling of bars built up columns of varying moments of inertia Lateral buckling of beams

Buckling of Plates Theory of plates Elastic theory of plates rectangular plates with various loading and edge conditions Fourierrsquos series finite differences energy and finite element methods exact theory of plates Circular plates continues plates and approximate methods of analysing rectangular grids Distribution of concentrated loads to the various beams in grid floor and bridge decks

References

SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959

4

K Chandrashekhara Theory of Plates University Press 2001

ACStress in plates and shells

SP Timoshenko JMGere Theory of elastic stability McGraw-Hill 1959

Subject Code Subject L T P D MM

CE552 THEORY OF ELASTICITY AND PLASTICITY

3 0 0 0

THEORY OF ELASTICITY AND PLASTICITY Theory of elasticity Stress tensor equations of equilibrium Kinematic relationships and equations of compatibility Generalised Hookrsquos law Boundary conditions Plane stress and Plane strain Airyrsquos stress function Saint Venantrsquos principal problems in rectangular and polar co-ordinates

Inverse and semi-inverse methods Torsion of prismatic bars Membrane analogy Typical applications

Theory of PlasticityHydro-static and deviatorinc components of stress tensor invariants of stress tensor Tresca-Saint Venants and Henky-von Mises yield conditions Octahedral stresses

Analysis of (I) Bending of bars of narrow rectangular cross section formation of plastic hinge

(II) Torsion of prismatic bars sand heap analogy

(III) Thick Spherical shell- bursting pressure

(IV) Thick cylindrical tube autofrettage

References

SPTimoshenko amp JNGoodier Theory of Elasticity McGraw Hill-1970

MKachanov Theory of Plasticity MIR Publication

CRCalladine Plasticity for Engineers Ellis Horwood Chichester UK 1985

Subject Code Subject L T P D MM

CE553 CADD Laboratory 0 0 2 0

CADD Laboratory

Introduction to computer aided design and drafting Soil structure interaction FEM modelling application to structural engineering problems of Multistoried Buildings Bridges Water Tanks suspension Bridges using commercial softwares such as STAAD-Pro E-TabsSAP NISHA MATLAB Earthquake resistant design and drawing detailing based on IS18932002 IS43261993IS4562000 drawing detailing using AUTOCAD and solid works

Subject Code Subject L T P D MM

CE601 STRUCTURAL DYNAMICS 3 0 0 0

Structural Dynamics

5

Oscillatory motion harmonic motion periodic motion vibration terminology Characteristics of a Dynamic Problem Prescribed Dynamic Loading Definition of Dynamic DOFs Mathematical modeling of dynamic systems Formulation of Equations of motion in Generalized SDOF SDOF MDOF discrete and continuous systems using drsquoAlembertrsquos Principle Principle of Virtual displacements and Variational Approach

Free vibration equations of motion-natural frequency Experimental determination of natural frequencies viscously damped free vibration Coulomb damping Response of SDOF system to harmonic periodic impulsive and general dynamic loading earthquake excitations in time and frequency domain Base excited systems Transmissibility and Vibration isolation Laplace transform formulation energy dissipated by damping equivalent viscous damping structural damping vibration measuring instruments

Free Vibration response of discrete MDOF systems eigen values eigen vectors Approximate methods for obtaining natural frequencies and mode shapes Forced Harmonic Vibration vibration absorber vibration damper Damping in structures

Free and Forced vibration of continuous systems

Concept of Spectral quantities response spectrum Discussion on IS 1893 part I 2000 codal provisions Response of linearly elastic systems using modal analysis

References

WTThomson Theory of Vibration with Applications Pearson Education

RW Clough amp JPenzien ldquoDynamics of Structures McGraw Hill

JLHumar ldquo Dynamics of Structurerdquo Prantice Hall

JW Smith ldquo Structural Dynamicsrdquo

AK Chopra ldquoDynamics of Structures Theory and Application to Earthquake Engineeringrdquo Prantice Hall India

Mario Paz ldquo Structural Dynamics theory and Computationsrdquo CBS Publishers

Roy L Craig ldquo Structural dynamics Introduction to Computational methodsrdquo John Wiley

Meiroritch ldquoFundamentals of variablerdquo Mc Graw Hall

Jaikrashna ldquo Element of earthquake enggrdquo South asia publishers pvt Ltd

Hurty and Rubinsion ldquoDynamics of structuresrdquo PHI

Subject Code Subject L T P D MM

CE6022 PLASTIC ANALYSIS OF METALLIC STRUCTURES (Design and Viva)

0 0 0 6

PLASTIC ANALYSIS OF METALLIC STRUCTURES (Design and Viva) Moment of resistance shape factor criteria of plastic analysis comparison of elastic and plastic analysis Moment-curvature relationships for beams Plastic hinges Redistribution of moments Analysis of indeterminate beams and frames for ultimate load by the statical method and mechanism methods Load interaction method Approximate method of finding ultimate load Uniqueness theorems Limit theorems-Upper and lower bound theorems Factors affecting the full plastic moments Influence of axial force and shear Estimation of deflections at ultimate load Local and letral buckling Design of connections Minimum weight design Shake down analysis

Limit state design of structures

References

6

Baker and Heyman ldquoPlastic design of framesrdquo volIampII

Subject Code Subject L T P D MM

CE6023 STRESS ANALYSIS 3 0 0 0

STRESS ANALYSIS Full field analysis by photoelasticity laser interferometry and moireacute techniques Method of brittle coating Use of micro-processors for stress analysis

References Dally ldquoExperimental stress analysisrdquo McGrawHill

Subject Code Subject L T P D MM

CE6021 MATERIAL SCIENCE AND TECHNOLOGY

3 0 0 0

MATERIAL SCIENCE AND TECHNOLOGY Material Technology Cements-properties Aggregates Admixtures Properties of fresh and hardened concrete Mixing compacting transporting and curing of concrete Non-destructive testing special types of concrete Temperature control in mass concrete Creep and Shrinkage phenomenon in concrete Mix design Behaviour of concrete combined stresses Tests in cement aggregates and concrete Material Science Structure of materials Bonding Phase equilibrium Mechanical properties Theories of failure for combined static creep and fatigue effects Brittle and ductile fracture Plastic deformations Structural imperfections and dislocations Strain hardening Electric and magnetic properties of materials Corrosion of materials and their prevention

References

Smith ldquoPrincipal of material science and enggrdquo

Nevilly ldquoconcrete technologyrdquo

ubject Code Subject L T P D MM

CE6031

DESIGN OF INDUSTRIAL STRUCTURE AND BRIDGE

0 0 0 6

DESIGN OF INDUSTRIAL STRUCTURE AND BRIDGE (Design and Viva)

(a) Design and analysis of multi storeyed framed structures (b) Design of liquid retaining structures

(c) Design and analysis of chimneys Design of Bridges IRC codal provisions strut and tie model Load path analysis

References

NKRaju Design of bridges Oxford amp IBH Publishing Co pvt ltd

DJVictor Essentials of bridge engineering Oxford amp IBH Publishing Co pvt ltd

7

Indian Road Congress Codes No56182124 Jamnagar House Shah Jahan Road New Delhi

SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959

OP Jain ampJaikrishna ldquoPlain and reinforced concreterdquo Nemchandamp brothers

Subject Code Subject L T P D MM

CE6032

Design of tall buildings 3 0 0 0

Design of tall buildings

1 Design Criteria

Design philosophy loading sequential loading materials- high performance concrete- fiber reinforced concrete- light weight concrete- design mixes

2 Loading and Movement

Gravity loading dead and live load method of live load reduction impact gravity loading construction loads

Wind loading static and dynamic approach analytical and wind tunnel experimental method

Earthquake loading Equivalent lateral force model analysis combination of loading working stress design limit state design plastic design

3 Behaviour of various structural systems

Factor affecting growth height and structural form high rise behavior rigid frames braced frames infilled frames shear walls coupled shear walls walls-frames tubular- braced and hybrid mega system

4 Analysis and Design

Modeling for approximate analysis accurate analysis and reduction techniques analysis of building as total structural system considering overall integrity and major sub system interaction analysis for member forces drift and twist computerized general three dimensional analysis

Structural elements sectional shapes properties and resisting capacity design deflection cracking prestressing shear flow design for deferential movement creep and shrinkage effects temperature effect and fire

5 Stability of tall buildings

Overall buckling analysis of frames wall-frames approximate methods second order effects of gravity of loadingP-Delta analysis translational torsional instability out of plum effects stiffness of member in stability effect of foundation rotation

References

Bungale STaranath ldquoStructure Analysis amp Design of Tall Buildingsrdquo Mcgraw Hill Book Company Newyork 1999

Mark Fintel ldquoHandbook of concrete enggrdquo CBS

Council of tall building ldquoAdvances in tall buildingrdquo CBS

Subject Code Subject L T P D MM

CE6033 Seismic Design of Structures 3 0 0 0

8

Seismic Design of Structures

1 INTRODUCTION Elements of engineering Seismology - Theory of Vibration - Response Spectrum

2 HISTORICAL Indian Seismicity-Earthquake history - Behaviour of structures in the past Earthquakes

3 DESIGN CONCEPTS Seismic Design Concepts ndash Cyclic load Behavior of RC Steel amp Prestressed Concrete Element - Design Spectrum ndash Principles of Capacity Design

4 CODAL PROVISIONS Provisions of Seismic Code (IS 1893IS4326) ndash Building systems Frames Shear Walls Braced frames Combinations- Torsion

5 DESIGN amp DETAILING Performance of Regular Buildings 3D Computer Analysis of Building Systems (Theory Only) ndash Design amp Detailing of frames ndash Shear Walls ndashFrame walls

6 SPECIAL PROBLEMS amp CASE STUDIES Structural Configuration ndash Seismic performance- Irregular Buildings- Soil Performance-Modern Concepts ndash Base Isolation ndash Adoptive System ndash Case Studies

References

1 Course Notes ldquoDesign of Reinforced Concrete Building IIT Kanpur June 1999 2 Bungale STaranath ldquoStructure Analysis amp Design of Tall Buildingsrdquo Mcgraw Hill Book Company Newyork 1999 3 Mark Fintel ldquoHandbook of concrete enggrdquo CBS

Subject Code Subject L T P D MM

CE564 Photo Elasticity Laboratory 0 0 2 0

Photo Elasticity Laboratory

Stress analysis Two and Three Dimensional Photo-elasticity

Subject Code Subject L T P D MM

CE6512 PRESTRESSED CONCRETE DESIGN 3 0 0 3

PRESTRESSED CONCRETE DESIGN (Design and Viva) Flexural strength of prestressed concrete sections shear and torsional resistance Transfer of prestress in pretensioned members Bond and transmission length Anchorage zone stresses in pot-tensioned members

Design of pre-tensioned and post-tensioned beams Statically indeterminate structures design of continuous prestressed concrete beams and prestressed portal frames

Prestressed concrete piles and sleepers

Deflection of prestressed concrete members

References

NKRaju-Pre Stressed Concrete YGuyon-Pre Stressed Concrete

9

Mitchel amp Michael ldquoPrestressed concrete structurerdquo PHI

NRajagopalan ldquoPrestressed concreterdquoNarosa publishing house

JRLibby ldquoModern prestressed concreterdquo

Subject Code Subject L T P D MM

CE6513 SHELLS AND FOLDED PLATES

3 0 0 3

SHELLS AND FOLDED PLATES (Design and Viva) Shells Membrane theory North light shells Cylindrical shells Doubly curved shells Analysis and Design

References

SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959

OP Jain ampJaikrishna ldquoPlain and reinforced concreterdquo Nemchandamp brothers

Mark Fintel ldquoHandbook of concrete enggrdquo CBS

Subject Code Subject L T P D MM

CE6511 Design of Structures for Dynamic loads 0 0 0 6

Design of Structures for Dynamic loads

1Introduction

Factors affecting design against dynamic loads- behavior of concrete steel masonry and soil under impact and cyclic loads- recap of structural dynamics with reference to SDOF MDOF and continuum systems- ductility and its importance

2 Design against Earthquakes

Earthquake characterization ndash response spectra- seismic coefficient and response spectra method of estimating loads- response of framed braced frames and shear wall buildings- design as per BIS codes of practice- ductility based design

3 Design against blast and impact

Characteristic of internal and external blast- impact and impulse loads-pressure distribution on building above ground due to external blast- underground explosion- design of buildings for blast and impact as per BIS codes of practice

4 Design against wind

Characteristic of wind- basic and design wind speeds- effect of permeability of structure- pressure coefficient- aeroelastic and aerodynamic effect- design as per BIS code of practice including Gust factor approach-tall buildings stacks and chimneys

5 Special considerations

Energy absorption capacity- ductility of material and structure- detailing for ductility-passive and active control of vibrations- new and favourable materials

References

1 buildingrdquo John Willey and sons 1991

10

2 DowlingCHrdquoBlast vibration- monitoring and controlrdquo Prentice Hall Inc Englewood cliffs 1985 3 Kolousek Net al ldquowind effect on civil engineering structuresrdquo Elsevier 1984 4 Concrete structure under the impact Bela Goschy ldquodesign of buildings to withstand abnormal loadingrdquo

Butterworths1990 5 Paulay T and priestly MNJ ldquoA seismic design of reinforced concrete and masonry and impulsive

loadingSynthesis report CEB Lousanne getmany1988

Subject Code Subject L T P D MM

CE6521 DESIGN OF HYDRAULIC STRUCTURES 3 0 0 0

DESIGN OF HYDRAULIC STRUCTURES

1 Project planning of hydraulic structure site investigation and chose of type of hydraulic structures

2 Different types of dam their design stress analysis stress concentration around openings

3 Different types of spillway and energy dissipaters their design and analysis Model analysis of hydraulic structures

4 Design of weirs and barrages and analysis

Subject Code Subject L T P D MM

CE6524 PLANNING AND DESIGN OF ENVIRONMENTAL SERVICES

3 0 0 0

PLANNING AND DESIGN OF ENVIRONMENTAL SERVICES

Planning factors Ventilation and air conditioning plumbing Design of public bathing lighting housing with environmental perspectives

References

BCPunamia ldquoenvironmental engg Part-2rdquo

SKGarg ldquoenvironmental enggrdquo

Subject Code Subject L T P D MM

CE6522 GROUND WATER AND SEEPAGE 3 0 0 0

GROUND WATER AND SEEPAGE

Darcyrsquos law General hydro-dynamic equations flow nets in isotropic and anisotropic medium

Steady and unsteady flow through confined and unconfined aquifers Schwartz-Christoffel transformation and its application for ground water flow and seepage problems Numerical Techniques for solution of ground water flow

Multiple well system partially penetrating wells image wells mutual interference of wells

Storage and exploration of ground water Design Construction and Maintainence of wells Ground water recharge and run off Water quality budgeting simulation of ground water basin Application of remote sensing for ground water

Subject Code Subject L T P D MM

11

CE6523 INSTRUMENTATION 3 0 0 0

INSTRUMENTATION

Types of applications of measurement instrumentation Generalised configurations and functional descriptions of measuring instruments Motion measurement Pressure measurement Flow measurement Environmental engineering Instrumentations

Subject Code Subject L T P D MM

CE653 Structural Dynamics Laboratory 0 0 2 0

Structural Dynamics Laboratory

Model Testing Models of Frames under Static and Dynamic Loading Free and Forced Vibration using MTS Determination dynamic Modulus Damping etc and some more experiment heavy structural engg lab

Subject Code Subject L T P D MM

CE7011 GEOTECHNICAL EARTHQUAKE ENGINEERING

3 0 0 0

GEOTECHNICAL EARTHQUAKE ENGINEERING Introduction to engineering seismology seismic risks and hazards causes and strength of earthquakes social and economic

consequences theory of dynamic and seismic response the nature and attenuation of earthquake magnitude ground motion

determination of site characteristics local geology and soil condition determination of design earthquake response spectra and

accelerograms Site response to earthquake site investigation and soil test dynamic behaviour of soils liquefaction phenomena

analysis of pore pressure development laboratory and in-situ testing for liquefaction analysis and design of slopes embankments

seismic response of soil structure system shallow foundation pile foundation foundations and earth retaining structures for

seismic loading case histories mitigation techniques

Subject Code Subject L T P D MM

CE7012 FOUNDATION ENGINEERING

3 0 0 0

FOUNDATION ENGINEERING Structures subjected to vertical and lateral loads excavation vertical cut retaining walls shallow foundation flexible and rigid rafts highway pavements allowable bearing pressure geo-technical investigation interpretation from field tests pile and cassion group action of piles pier shafts in rock socket Foundations subjected to dynamic loads theory of vibrations natural frequency of a soil foundation system Elastic constant of soils pressure bulb concept permissible amplitude various considerations for machine foundation Strength and deformation characteristics of granular media under dynamic loads Liquefaction References

BM Das Advanced Foundation Engineering Brookes and Cole India

J Bowels Foundation analysis McGrawHill Publishers

Rao NSVK Vibration analysis and foundation dynamics AH Wheeler amp Co New Delhi India

Subject Code Subject L T P D MM

12

CE7013 SOIL STRUCTURE INTERACTION 3 0 0 0

Soil Structure Interaction

1 SOIL FOUNDATION INTERACTION Introduction to soil foundation interaction problems Soil Behaviour Foundation Behaviour Interface behaviour Scope of soil foundation interaction analysis Soil response models Winkler Elastic Continuum Two parameter elastic models Elastic plastic behaviour Time dependent behaviour

2 BEAM ON ELASTIC FOUNDATION ndash SOIL MODELS Infinite beam Two Parameters Isotropic elastic half space Analysis of beams of finite length Classification of finite beams in relation to their stiffness

3 PLATE ON ELASTIC MEDIUM Infinite Plate Winkler Two parameters Isotropic elastic medium Thin amp Thick plates Analysis of finite plates rectangular amp circular plates Numerical analysis of finite plates simple solutions

4 ELASTIC ANALYSIS OF PILE Elastic analysis of single pile Theoretical solution for settlement amp Load Distributions Analysis of Pile Group Interaction Analysis Load Distribution in groups with Rigid Cap

5 LATERALLY LOADED PILE Load Deflection Prediction for Laterally loaded piles Sub-grade reaction amp Elastic analysis Interaction analysis Pile raft system Solutions through influence charts

References 1 Selva durai APS Elastic analysis of Soil Foundation Interaction Elsevier 1979 2 Poulos HG amp Davis EH Pile Foundation Analysis amp Design John Wiley 1980 3 Scott RF Foundation Analysis Prentice Hall 1981 4 Structure Soil Interaction-State of Art Report Institution of Structure Engineers 1978 5 ACI 336 Suggested Analysis and Design Procedure for Combined Footings amp Mats American Concrete Institute Delhi

1988 6 SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959 7 SP Timoshenko Strength of material CBS Publisher 8 Bowles ldquoFoundation analysis and designrdquo McGrawHill

Subject Code Subject L T P D MM

CE7022 DISASTER RESISTANT STRUCTURES 3 0 0 0

Disaster Resistant Structures

1 BEHAVIOUR OF LIFE ndash LINE STRUCTURES Philosophy for design to resist earthquake Cyclone amp Flood-National amp International Codes of practice- By ndash Law of urban amp Semi-urban areas- Traditional amp Modern Structures

2 COMMUNITY STRUCTURES

Response of dams bridges buildings- Strengthening measures- Safety analysis and rating-Reliability assessment

3 REHABILITATION AND RETROFITTING

Testing and evaluation-Classification of structures for safety point of view- methods of strengthening for different disasters ndash qualification test

4 DETAILING OF STRUCTURES AND COMPONENTS

Use of modern materials amp their impact on disaster reduction- Use of modern analysis Design amp Construction techniques optimization for performance

5 DAMAGE ASSESSMENT OF STRUCTURES

Damage surveys- Maintenance and Modification to improve hazard resistance- Different types of Foundation amp its impact on safety- Ground improvement techniques

13

References

1 VMoskvin etall Concrete and Reinforced Concrete- Deterioration amp Protection- Mir Publishers-Moscow 1980 2 RTAllen and SCEdwards Repair of Concrete Structures Blakie and Sons UK 1987 3 3Proceedings IABSE 14th Congress ldquoCivilization through Civil Engineeringrdquo New Delhi May 1992 4 Raiker RNLearning from failure deficiencies in Design Construction and Service R amp D Centre (SDCPL) Raiker

Bhawan Bombay 1987 5 IS13827IS13828IS13935 6 ISO23941382315686 Part I to IX

Subject Code Subject L T P D MM

CE7021 ADVANCED BUILDING CONSTRUCTION AND MANAGEMENT

3 0 0 0

ADVANCED BUILDING CONSTRUCTION AND MANAGEMENT New techniques and materials of building construction Building construction management techniques

References

1 LSShrinath ldquoCPM ampPERTrdquo 2 Software PRIMAVERA-2 or above 3 Peurifoy ldquoConstruction planning equipment and methodsrdquo

Subject Code Subject L T P D MM

CE7023 Soil Dynamics and Geotechnical Earthquake Engineering

3 0 0 0

Soil Dynamics and Geotechnical Earthquake Engineering

Seismology and Earthquakes seismic hazard Analysis Engineering Problems involving Soil Dynamics Wave propagation in elastic media General nature of Soil Behaviour under cyclic dynamic loading Field and laboratory tests for measurement of small strained and large strain dynamic properties of soils

Strong Ground Motion measurement characterization and estimation Amplification Theory and Ground Response Analysis Local Site Effects and Design Ground Motions

Liquefaction Evaluation of liquefaction hazards susceptibility

Study of Initiation of liquefaction Characterization of Liquefaction resistance based on lab and in-situ tests and Evaluation of Initiation of Liquefaction

Study of effects of liquefaction

Seismic Slope Stability Seismic Design of retaining walls Soil Improvement for remediation of Seismic Hazards

References

Steven L Kramer lsquoGeotechnical Earthquake Engineeringrdquo Pearson Education

14

Scheme for M Tech (Geotechnical Engineering)

Sem Gp Course Details Course Code

L T P Intern Marks

Extern Marks

Total Marks

Credits

Ist A Advanced Soil mechanics CE521 3 0 0 50 100 150 3 Rock Mechanics CE523 3 0 0 50 100 150 3 Geotechnical Exploration CE522 3 0 0 50 100 150 3 Geotechnical Egg Lab-I CE524 0 0 2 30 70 100 2

B Advanced Foundation Engineering CE571 3 0 0 50 100 150 3 Soil Dynamics and Machine Foundations

CE572 3 0 0 50 100 150 3

Geotechnical Egg Lab-II CE573 0 0 2 30 70 100 2 Self Study open area seminar-I CE574 0 0 2 50 00 50 1

21Hoursweek 1000 20 IInd C Application of Geotechnical Engg in

Water Resources amp GIS CE621 3 0 0 50 100 150 3

Elective I any one of the following 1 Computational Geotechnics 2 Plasticity amp fracture Mechanics in

Rock Structures 3 Theoretical Soil Mechanics

CE6221 CE6222 CE6223

3 0 0 50 100 150 3

Elective II any one of the following 1 Design of Hydraulic Structures 2 Geo-environmental Engineering 3 Groundwater and Seepage

CE6231 CE6232 CE6233

3 0 0 50 100 150 3

Geotechnical Engg Lab-III CE624 0 0 2 30 70 100 2 D Elective III any one of the following

1 Excavation Technology 2 Geotechnical Earthquake

Engineering 3 Theory of Elasticity and Plasticity

CE6711 CE6712 CE6713

3 0 0 50 100 150 3

Elective IV any one of the following 1 Ground Improvement Techniques 2 Geosynthetics 3 Slope Stability Analysis

CE6721 CE6722 CE6723

3 0 0 50 100 150 3

Geotechnical Engg Lab IV CE673 0 0 2 30 70 100 2 Minor Project I CE674 0 0 2 50 00 50 1

21Hoursweek 1000 20 IIIrd E Elective V any one of the following

1 Critical State Soil Mechanics 2 Design of Sub-structures 3 Soil Structure Interaction

CE7211 CE7212 CE7213

3 0 0 50 100 150 3

Elective VI any one of the following 1 Earth Pressure amp Earth Retaining

Structures 2 Offshore Geotechnical

Engineeging 3 Unsaturated Soil Mechanics

CE7221 CE7222 CE7223

3 0 0 50 100 150 3

Self Study open area seminar II CE723 0 0 2 50 00 50 1 Minor Project II CE724 0 0 4 00 200 200 4 Major Project part I CE725 0 0 2 200 00 200 4

18Hoursweek 750 15 IVth F Major Project Part II CE821 3 0 0 00 750 750 15 6Hrsw

k 750 15

Grand Total 3500 70

15

Advanced Soil Mechanics

Paper Code L T P Cr

CE 521 3 0 0 3

Clay minerology clay-water electrolyte system soil structure and fabric Effective stress hydraulic conductivity seepage Special

soils collapsible amp sensitive clays loessic bouldary and expansive soils Consolidation one-dimensional and generalised

consolidation theories primary and secondary consolidation sand drains consolidation settlements Shear behaviour of soils pore

pressure parameters UU CUampCD tests stress path method for settlement analysis Total amp effective stress-path water content

contours stress history Anisotrppy of strength Thixotropy Creep Determination of in situ undrained shear strength stress-strain

characteristics of soilsDetermination of modulus values Critical state model

20 Rock Mechanics

Paper Code L T P Cr

CE523 3 0 0 3

Introduction problems of rock mechanics classifications of rock masses rock exploration ndash rock coring geophysical methods

laboratory testing of rocks fraction in rocks elasticity amp strength of rocks strength amp failure of rocks Griffithrsquos theory

Coulombrsquos theory in-situ tests on rock mass deformation characteristics instrumentation and measurement of deformation of

rocks permeability Mechanical thermal and electrical properties of rock mass openings in rock mass and stresses around

openings slope stability pressure tunnels development of plastic zone rock support needed to avoid plastic deformation lined

and unlined tunnels support pressure and slip of the joint underground excavation and subsidence foundation on rocks bearing

capacity of intact and jointed rocks rock slopes rock bolt anchors amp grouting underground openings pillars tunnels methods of

construction problems associated with tunnels tunnelling in various subsoil conditions and rocks

30 Geotechnical Exploration

Paper Code L T P Cr

CE 522 3 0 0 3

Planning of geotechnical exploration methods of boring Boring in soils and rocks methods of stabilizing the bore holes

Sampling techniques Sampling disturbances storage labeling and transportation of samples sampler design influence on

properties field tests standard penetration plate load static and dynamic cone penetration field vane shear and pressuremeter

tests electrical resistivity and seismic refraction tests location of ground water table processing of soil exploration data and its

interpretation

40 Geotechnical Engineering Lab I

Paper Code L T P Cr

CE 524 0 0 2 2

This Laboratory is based on the syllabus of CE 541 CE 542 CE 543

16

50 Advanced Foundation Engineering

Paper Code L T P Cr

CE 571 3 0 0 3

Shallow foundations subjected to static eccentric and inclined loads bearing capacity analysis settlement amp allowable bearing

capacity of shallow foundation uplift capacity of shallow foundation raft foundations pile foundations-design in different soil

conditions load distribution between vertical and battered piles moment on pile foundations group effect on piles raft on piles

piers and pier shafts caisson settlement analysis of pile groups amp shafts analysis amp design of well foundation foundation on

reinforced soil

60 Soil Dynamics amp Machine Foundation

Paper Code L T P Cr

CE 572 3 0 0 3

Introduction fundamentals of vibrations vibration of elementary systems-mass spring

dashpot systems various degrees of freedom dynamic properties of geo-materials propagation of wave in granular media

laboratory and field tests for evaluation of dynamic soil properties analysis and design of foundations for hammers reciprocating

engines and turbo generators dynamic stiffness of single pile and pile groups vibration isolation and damping theories for

vibration of foundations on elastic media design procedures for foundations with dynamic load and construction features elastic

homogeneous half space solutions lumped parameter solutions large deformation problems liquefaction of soils amp cyclic

mobility

70 Geotechnical Engineering Lab II

Paper Code L T P Cr

CE 573 2 2

This Laboratory is based on the syllabus of CE 541 542 543 545 546

8 Application of Geotechnical Engg in Water Resources amp GIS

Paper Code L T P Cr

CE 621 3 -- -- 3

Selection of sites for different water resources projects Geotechnical investigations Classification of dams Causes of failure of

earth dams relative advantages and disadvantages of earth dams over gravity dam Preliminary section of earth dams Typical

section of earth dams Checking the stability of earth dams Slope stability analysis Stability of foundation of earth dams against

shear Design consideration of earth dam in seismic regions Rockfill dam impervious membrane type rockfill dam design

consideration of rockfill dam Hydroelectric power classifications and investigations Features and characteristics of hydropower

generation and Principal components of a hydropower station Design of different components like Intakes Water conductor

system Tunnels Surge tanks Penstocks Anchor blocks and their management at site

17

Introduction to GIS and remote sensing cartographic data model digital data model data source data capture and data analysis

role of remote sensing and GIS in flood disaster studies Landslides and Earthquake Various GIS packages and their salient

features

90Elective I Opt any one of the following

10 Theoretical Soil Mechanics

20 Computational Geotechnics

30 Plasticity amp Fracture Mechanics in Rock Structures

100Elective II Opt any one of the following

40 Geo-environmental Engineering

50 Ground water amp Seepage

60 Design of Hydraulic structures

110 Geotechnical Engineering Lab III

Paper Code L T P Cr

CE 624 2 2

This Laboratory is based on the syllabus of courses mentioned above

120Elective III Opt any one of the following

70 Goetechnical Earth quake Engineering

80 Theory of Elasticity and Plasticity

90 Excavation Technology

130Elective IV Opt any one of the following

100Ground Improvement Techniques

110 Geosynthetics

120 Slope Stability Analysis

140 Geotechnical Engineering Lab IV

Paper Code L T P Cr

CE 673 2 2

This Laboratory is based on the syllabus of courses mentioned above

150Elective V Opt any one of the following

130 Critical State Soil Mechanics

140 Design of Sub Structures

18

150 Soil Structure Interaction

160Elective VI Opt any one of the following

160 Unsaturated Soil Mechanics

170Flow Through Porous Media

180 Earth Pressure amp Earth Retaining Structures

SYLLABUS OF ELECTIVE COURSES

10 Theoretical Soil Mechanics

Paper Code L T P Cr

CE 6223 3

Stresses and strains elastic equilibrium analysis for plane strain and three dimensional cases Effective stresses analysis of

deformation and strain states of stress and strain consitutive relationsequilibrium and compatibilitygeneral theorems drained

and undrained loading state boundary surface plastic flow yield and hardeningfailure theorems for soils failure and plastic flow

at critical state associative and non-associative flow residual strength anisotropic compressions ideal elastic behaviour ndash two

and three dimensional systems theorems of plastic collapse and their application to soil-structure interaction elastoplastic theory

of soils rheological models nonlinear viscoelasticity problems and solutions

20 Computational Geotechnics

Paper Code L T P Cr

CE 6221 3

Introduction to numerical modeling in Geotechnical Engineering basic concepts stress deformation analysis analysis of

foundations dams underground structures and earth retaining structures Finite difference method Finite element method

Boundary element method Discrete element method Constitutive modeling use of finite element finite difference and discrete

element computer codes for solving geotechnical engineering problems Use of some of the appropriate software package like

UDEC FLAC PLAXIS etc

3 Plasticity amp Fracture Mechanics in Rock Structures

Paper Code L T P Cr

CE 6222 3

Theory of plasticity Three dimensional stress analysis stress invariants octahedral stresses Large deformationsfinite strains -

Euler amp Langragian approaches Greenrsquos amp Cauchyrsquos strain tensors Yield criteria Von Mises Tresca Mohr-Coulomb Drucker-

Prager Modified Mohr-Coloumb Hoek amp Brown yield criteria Isotropic and Kinematic hardening softening normality principle

plastic flow rule plastic potential Druckerrsquos postulates and Prandtlrsquos conditions for stability of plastically deforming bodies

Plastic Stress-Strain relations Stress path dependent behaviour Prandtl-Rauss equations Levy-Mises relations generalised

19

elasto-plastic stress-strain realtionshardening modulus Applications to problems of tunnels etc Crack phenomenon and

mechanics of brittle fracture propagation effects of crack on elasticproperties Energy theories of failure elementary theories of

crack propagation cracks in elasto-plastic media Constitutive equations for rocks ndash Class I and Class-II materials Servo

controlled testing and post failure behaviour under uniaxial and triaxial stress conditions in tension Compression and shear size

effects representative size of specimen Continum characterization of jointed rock mass Weibullrsquos thoery in tension

compression and bending for strength constitutive equations for discontinuities ndash Joint stiffnesses and shear strength Ladanyirsquos

constitutive equations Stick Slip phenomenon Application of fracture mechanics to underground opening rock stabbing bursting

and hydraulic fracturing

40 Geo Environmental Engineering

Paper Code L T P Cr

CE 6232 3

Introduction Sources of subsurface contamination Mechanisms of Soil contamination Physical-chemical and biological

interactions in soils Effect of contamination on geotechnical properties Waste disposal on land Types of landfills Siting criteria

waste containment principles Types of barrier materials Planning and design aspects relating to waste disposal in landfills in ash

ponds and tailing ponds Environmental monitoring around landfills Detection control and remediation of subsurface

contamination Various types of barrier systems Reclamation of contaminated sites Case Studies

50Ground Water and Seepage

Paper Code L T P Cr

CE 6233 3

Darcyrsquos law General hydro-dynamic equations flow nets in isotropic and anisotropic

medium Steady and unsteady flow through confined and unconfined aquifers Schwartz-Christoffel transformation and its

application for ground water flow and seepage problems Multiple well system partially penetrating wells image wells mutual

interference of wells Storage and exploration of ground water design construction and maintenance of wells ground water

recharge and run off water quality budgeting simulation of ground water basin application of remote sensing for ground water

60 Design of Hydraulic Structures

Paper Code L T P Cr

CE 6231 3

Project planning site investigations choice of type of dams cost-benefit studies Non-overflow dams gravity arch and buttress

type rock-fill and earthen dams their design stress analysis stress concentration around openings Different types of spillways

and energy dissipaters their design preparation and protection of foundation for dams model analysis of hydraulic structures

instrumentation in dams temperature control in concrete dams

70 Geotechnical Earthquake Engineering

Paper Code L T P Cr

20

CE 6712 3

Introduction to engineering seismology seismic risks and hazards causes and strength of earthquakes social and economic

consequences theory of dynamic and seismic response the nature and attenuation of earthquake magnitude ground motion

determination of site characteristics local geology and soil condition determination of design earthquake response spectra and

accelerograms Site response to earthquake site investigation and soil test dynamic behaviour of soils liquefaction phenomena

analysis of pore pressure development laboratory and in-situ testing for liquefaction analysis and design of slopes embankments

seismic response of soil structure system shallow foundation pile foundation foundations and earth retaining structures for

seismic loading case histories mitigation techniques

80 Theory of Elasticity and Plasticity

Paper Code L T P Cr

CE 6713 3 - -

Theory of Elasticity Stress tensor equations of equilibrium Kinematic relationships and equations of compatibility Generalized

Hookersquos Law Boundary conditions Plane stress plane strain Airyrsquos stress function Saint Venantrsquos principle Problems in

rectangular and polar co-ordinates inverse and semi-inverse methods torsion of Prismatic bars members analogy typical

applications Theory of plasticity hydro-static and deviatoric components of stress tensor invariant of stress tensors Tress-Saint

Venant and Honkey-Von Misses yield conditions octahedral stresses Analysis of Bending of bars of narrow rectangular

cross section-formation of Plastic hinge Torsion of prismatic bars-sand-heap analogy Thick spherical shell-bursting pressure

Thick cylindrical tube

90Excavation Technology

Paper Code L T P Cr

CE 6711 3

Construction Planning amp scheduling Importance of planning pre-planning analysis Network planning including CPM amp PERT

techniques Contract management Contractual Risks amp Risk management Excavation in soils Tractors Dozers Bull-dozers

Wheel Loaders Shovels Draglines Buckets Clampshells Scrapers Hydraulic Excavators Excations in Rocks manual

excavation tools and techniques Drilling and blasting versus Ripping Excavations of Dam Foundations Controlled drilling and

blasting Selection and matching of loading and hauling equipment Excavations of tunnels amp caverns Type of cuts and drilling

patterns Methods of Tunnel driving Excavation cycles Full face heading heading and benching Ring drilling method

Forepoling Side drift method Presplitting and smooth blasting Excavation in different ground conditions mixed face tunneling

Machine Tunneling Shield tunneling Types of TBMs new TBMs New Austrian Tunneling Method(NATM) Norweign

Tunneling Method (NTM) TBMs versus drilling and blasting TBM in different ground conditions Limitations of machine

tunneling Excavations of Shafts and Caverns Excavation with limit raiser climber Shaft boring lining segments for shield driven

tunnels Differnet stages in excavation of caverns Ventilation in Long Tunnels

100 Ground Improvement Technique

Paper Code L T P Cr

CE 6721 3

21

Ground improvement principles of ground improvement mechanical modificationproperties of compacted soil compaction

control tests hydraulic modification dewatering systems filtration drainage and seepage control with geosynthetics preloading

and vertical drains electro kinetic dewatering chemical modification modification by admixtures stabilization using industrial

wastes grouting modification by inclusion and confinement soil reinforcement flexible geosynthetic sheet reinforcement

anchorage reinforcement techniques bearing capacity improvement slope stability erosion control retaining walls and

pavements Soil stabilization shallow stabilization with additives lime flyash cement and other chemicals and bitumen deep

stabilization sand column stone column sand drains prefabricated drains electro-osmosis lime column soil-lime column

grouting permeation compaction and jet vibro-floatation dynamic compaction thermal freezing dewatering systems

110 Geosynthetics

Paper Code L T P Cr

CE 6722 3

Geosynthetics types and functions materials and manufacturing processes testing and evaluations principles of soil

reinforcement design and construction of geosynthetic reinforced soil retaining structures walls and slopes Geosynthetics in

pavements geosynthetics in roads and railways separations drainage and filtration in road pavements and railway tracks design

and construction relevant guidelines Geosynthetics in pollution control liners for ponds and canals covers and liners for

landfills material aspects and stability considerations

120 Slope Stability Analysis

Paper Code L T P Cr

CE 6723 3

Introduction Natural and man made slopes types of slope movements amp land slides nature of soil amp rock Progressive failure of

slopes Limit Equlibrium Methods Infinite and finite height slopes Planar failure surface Slip surface of arbitrary shape Natural

slope analysis considering initial stresses Sewdish method Bishoprsquos simplified methodother methodsstability chart Various

conditions of analysis factor of safety codal provisions Some special aspects of slope analysisie Earthquakes Creep

Anisotropy Probabilistic approach in slope analysis Centrifuge Model testingReinforced slopesembankment on soft soils

130 Critical State Soil Mechanics

Paper Code L T P Cr

CE 7211 3 - -

Review of stress and effective stress analysis of deformation and strain ideal elastic behavior elastoplastic behavior of soils

stress path and invariants constitutive relations drained and undrained loading isotropic compressions elastic wall state

boundary surface associative and non-associative flow yield and hardening critical state line amp Roscoe surface plastic collapse

residual strength behavior of oc clays for Hvorslev surface critical state for sand effect of dilation applications

140 Design of Sub-Structures

Paper Code L T P Cr

CE 7212 3

22

Introduction Substructure ndash Definition and purpose role of foundation engineern Basic Soil input parameters for foundation

design Foundation Design General principles Types of foundations selection of type of foundation Basic requirements

Computation of loads Limit State Design Basic principles Shallow Foundations Types and their selection Conventional

method of design Beams on elastic foundation and Finite difference method of analysis Structural design of footings and rafts

Foundations subjected to eccentric-inclined loads Footing in seismic zones Pile Foundations Type construction techniques

Proportioning of pile foundations loadsforces considered for structural design Structural design of pile foundation for a

multistoreyed buildings and other important structures Pile foundations subjected to dynamic loads Bridge Substructures _

Forces on bridge Foundation (IRC amp IS specifications) Design of piers Abutments amp wing Walls Well Foundation Components

Stability analysis Design of various components Materials for construction Sinking of well Placing of Curb Dredging and

Jetting marine Substructure Types Breakwaters Wharves Sea Walls Design and Construction Methods Foundations of

transmission line towers forces on tower foundation General design criteria Choice amp type of foundation Design Procedure

150 Soil-Structure Interaction

Paper Code L T P Cr

CE 7213 3

General soil-structure interaction problems contact pressures and soil-structure interaction for shallow foundations concept of

sub grade modulus effectsparameters influencing subgrade modulus analysis of foundations of finite rigidity beams on elastic

foundation concept introduction to the solution of beam problems Curved failure surfaces their utility and analyticalgraphical

predictions from Mohr-Coulomb envelope and circle of stresses earth pressure computations by friction circle method earth

pressure distribution on walls with limitedrestrained deformations Dubravorsquos analysis earth pressures on sheet piles braced

excavations design of supporting system of excavations arching in soils elastic and plastic analysis of stress distribution on

yielding bases Modern concept of analysis of piles and pile groups axially laterally loaded piles and groups interaction analysis

Reese and Matlockrsquos tunnelling solution elastic continuum and elasto-plastic analysis of piles and pile groups Hrennikoffrsquos

analysis ultimate lateral resistance of piles by various approaches non-linear load-deflection response uplift capacity of piles and

anchors

160 Unsaturated Soil Mechanics

Paper Code L T P Cr

CE 7223 3

Identification and classification of expansive and collapsing soils effective stress concepts matric and osmotic suction collapse

heave and strength characteristics of unsaturated soils flow through unsaturated soils laboratory evaluation of swell pressure and

swell potentialtests to evaluate collapse potential measurements of soil suction

170Offshore Geotechnical Engineeging

Paper Code L T P Cr

CE 7222 3

Submarine soilsoriginnature and distributionTerriginic and pelagicsubmarine soils of India Engineering behaviour of

submarine soilsunder consolidated soilscalcareous soilscemented soilscorals

23

Offshore site investigations sampling and sampling disturbanceinsitu testingwireline technologyoffshore pile foundations for

jacket type structuresfoundations of gravity structures

Foundations for jack-up rigsanchors and break out forcesanchor systems for floating structuresstability of submarine

slopesInstallation and stability of submarine pipelines

180 Earth Pressure amp Earth Retaining Structure

Paper Code L T P Cr

CE 7221 3

Earth pressure theories Rankines theory Coulombs theory graphical techniques amp analytical methods rigid retaining structures

types empirical methods stability analysis Flexible retaining structures types material cantilever sheet piles anchored

bulkheads ndash free earth method fixed earth method moment reduction factors anchorage Braced excavation types construction

methods pressure distribution in sands and clays stability - bottom heave seepage ground deformation Reinforced soil walls

elements construction methods external stability internal stability Arching action underground structures in soils pipes

conduits trenchless technology tunnelling techniques - cut-and-cover method shield tunnelling Stability of slopes analysis of

earth amp rock fill dam

Recommended Books-

1 The Mechanics of Soils JH Atkinson amp PL Brandsy (1982) 2 Critical State Soil Mechanics AN Schofield amp CP Wroth (1968) 3 Introduction to Rock Mechanics RE Goodman (1989) 4 Engineering in Rocks T Ramamurthy (2007) 5 Shallow Foundation BM Das (1999) 6 Foundation Analysis amp Design JE Bowles (1988) 7 Foundation Engineering G Leonards (1962) 8 Basic amp Applied Soil Mechanics G Ranjan amp ASR Rao (2006) 9 Soil Dynamics S Saran (1999) 10 Geotechnical Earthquake Engineering SL Kramer (2003) 11 Geotechnical Modelling DM Wood (2004) 12 Analysis amp Design of Substructures S Saran (1996) 13 Geotechnical Practice for Waste Disposal DE Danial (1993) 14 Ground Water DK Todd (1959) 15 Designing with Geosynthetics RM Koerner (1997) 16 Ground Water amp Seepage ME Harr (1962) 17 Ground Water amp Seepage DK Todd (1959) 18 Engineering Hydrology SS Butler (1959) 19 Ground Water its development uses and conservation EW Bennisen (1972) 20 Theory of Elasticity amp Plasticity SP Timoshenko amp JN Goodier (1982) 21 Soil Mechanics in the light of Critical State Theories JAR Ortigao (1995) 22 Design of Small Dams USBR Manual (1965) 23 Design and Construction of Dams Edward Wegwann (1978) 24 Earth and Rock Dams Sheard L James 25 Properties of Concrete AM Neville (2007) 26 The Chemistry of Cement and Concrete FM Lea (1970) 27 Soil Mechanics Principle and Practice GE Barnes (2000) 28 Advanced Soil Mechanics BM Das (1997) 29 Soil Mechanics for Unsaturated Soils DG Fredlund and H Rahardjo (1993) 30 Soil Mechanics TW Lambe and RV Whitman (1987) 31 Fundamentals of Soil Behaviour James K Mitchell (1993) 32 Principles of Soil Mechanics RF Scott (1963) Foundation Analysis and Design JE Bowles (1996) 34 Foundation Design Principles and Practices Donald P Coduto (2001)

24

35 Design Aids in Soil Mechanics and Foundation Engineering Shenbaga R Kaniraj (1988) 36 Pile Foundation Analysis and Design HG Poulus and EH Davis (1980) 37 Earth and Earth-Rock Dams JL Sherard RJ Woodward SF Giziensky and WA Clevenger (1963) 38 Soil Mechanics in Engineering Practice K Terzaghi RB Peck and G Mesri (1996) 39 Foundation Design and Construction MJ Tomlinson (1996) 40 Engineering Treatment of Soils FC Bell (1993) 41 Earth Reinforcement and Soil Structures JFP Colin (1996) 42 Foundation Engineering Handbook HY Fang (1991) 43 Engineering Principles of Ground Modification MR Hausmann (1990) 44 Ground Improvement MP Moseley (1993) 45 Ground Control and Improvement PP Xanthakos LW Abramson and DA Bruce (1994) 46 Design Construction and Monitoring of Landfills A Bagchi (1994) 47 Geoenvironmental Engineering LN Reddi and HI Inyang (2000) 48 Environmental Geotechnics R Sarsby (2000) 49 Planning Design and Analysis of Tailings Dams SG Vick (1970) 50 Earthquakes Bruce A Bolt (1999) 51 Exploration Geophysics of the Shallow Subsurface Robert H Burger (1992) 52 Principles of Soil Dynamics BM Das (1993) 53 Geotechnical Earthquake Engineering Handbook RW Day (2002) 54 Construction Vibrations CH Dowding (2000) 55 Soil Behaviour in Earthquake Geotechnics Kenji Ishihara (1996) 56 Geotechnical Earthquake Engineering SL Krammer (1996) 57 Cyclic Loading of Soils from Theory to Design MP OrsquoReilly and SF Brown (1991) 58 Foundations for Machines Analysis and Design S Prakash and V K Puri (1988) 59 Dynamic Soil Structure Interaction John P Wolf (1985) 60 Rock Engineering JA Franklin and MB Dusseaut (1989) 61 Introductory Rock Mechanics RF Goodman (1980) 62 Foundation of Theoretical Soil Mechanics ME Harr (1966) 63 Fundamentals of Rock Mechanics JC Jaeger and NGW Cook (1969) 64 Elastic Solutions for Soils and Rock Mechanics HG Poulos and EH Davis (1974) 65 Rock Mechanics in Engineering Practice KG Stagg and OC Zienkiewics 66 Numerical Methods in Geotechnical Engineering DesaiCS and Christian 67 Finite Element Procedures in Engineering Analysis BatheKJ 68 Soil Behaviour and Critical State Soil Mechanics Wood DM

25

Scheme for M Tech (Environmental Engineering)

Sem Gp Course Details Course Code

L T P Intern Marks

Extern Marks

Total Marks

Credits

Ist A Advanced Mathematics and Statistics CE-511 3 0 0 50 100 150 3 Environmental Chemistry and Microbiology

CE512 3 0 0 50 100 150 3

Water Pollution CE513 3 0 0 50 100 150 3 Microbiology Lab CE514 0 0 2 30 70 100 2

B Air Pollution amp Control CE561 3 0 0 50 100 150 3 Water Engineering Design CE562 3 0 0 50 100 150 3 Water Engineering Laboratory CE563 0 0 2 30 70 100 2 Self Study open area seminar-I CE564 0 0 2 50 00 50 1

21Hoursweek 1000 20 IInd C Wastewater Treatment Design CE611 3 0 0 50 100 150 3

Elective I any one of the following 1 Groundwater and Seepage 2 Instrumentation

CE6121 CE6122

3 0 0 50 100 150 3

Elective II any one of the following 1 Design of Hydraulic Structures 2 Industrial Wastewater Treatment

CE6131 CE6132

3 0 0 50 100 150 3

Air Pollution Laboratory CE614 0 0 2 30 70 100 2 D Elective III any one of the following

1 Global Warming and Climate Change

2 Planning and Design of Environmental Services

CE6611 CE6612

3 0 0 50 100 150 3

Elective IV any one of the following 1 Environmental Planning and

Management 2 Solid Waste Management

CE6621 CE6622

3 0 0 50 100 150 3

Solid Waste amp Industrial Wastewater Analysis Lab

CE663 0 0 2 30 70 100 2

Minor Project I CE664 0 0 2 50 00 50 1 21Hoursweek 1000 20 IIIrd E Elective V any one of the following

1 Environmental Impact Assessment and Audit

2 Remote Sensing and GIS in Environmental Engineering

CE7111 CE7112

3 0 0 50 100 150 3

Elective VI any one of the following 1 Air Quality Modeling 2 Hazardous Waste Management 3 Occupational Safety and Health

CE7121 CE7122 CE7123

3 0 0 50 100 150 3

Self Study open area seminar II CE713 0 0 2 50 00 50 1 Minor Project II CE714 0 0 4 00 200 200 4 Major Project part I CE715 0 0 2 200 00 200 4

18Hoursweek 750 15 IVth F Major Project Part II CE811 3 0 0 00 750 750 15 6Hrsw

k 750 15

Grand Total 3500 70

26

MTech(Civil) Environmental Engineering

GROUP lsquoArsquo SUBJECTS

CE-511 Advanced Mathematics and Statistics

Numerical Methods - Partial differential equations Newton-Raphson method Finite difference finite element method of characteristics different methods Successive over relaxation methods Optimization ndash classification and importance in Environmental Studies Single and multivariable optimization without and with constraints Linear Programming ndash different methods linear approximation of non-linear optimization Statistics - Significance Tests Frequency Distribution Characteristics of Distributions Method of Least Squares and Regression Multiple Regression Probability ndash Concepts Methods Binomial Poisson and Normal distribution Risk and uncertainty analysis

CE-512 Environmental Chemistry and Microbiology

Aquatic Chemistry Hydrological cycle structure of water molecule water as solvent principles of equilibrium chemistry pH oxidation-reduction and the application of principles of chemistry for solving Environmental Engg problems

Chemistry of pollution due to detergents pesticides polymers trace organics metals mining petroleum and radioactive compounds

Chemistry of the atmosphere Global environmental problems- chemistry of CFC ozone depletion green house effect etc

Environmental Microbiology basic principles of microbial transformation of organic matter Microbial biochemistry biodegradation acclimatization of wastes and microbial inhibition mechanisms

Structure and function of cell constituents pure and mixed cultures aerobic and anaerobic metabolism microbial growth and dynamics microbial taxonomy classification amp morphological aspects of protozoa bacteria fungi algae and other higher aquatic life forms

Bioassay tests for toxicity evaluation pathogens and indicator organisms

Environmental Biotechnology Role of microbes in water and wastewater Engg Microbiology applied to bio scrubbers and bio filters bioremediation

CE-513 Water Pollution

Water quality Detection and measurement of Water Pollution Stream surveillance Standards Criteria Objective and goal of water quality for different uses Water quality management

Modeling approaches to water quality - classification ndash Mathematical Models for water quality

DO Models for Streams Models for microorganisms decay Eutrophication models - simplified nutrient loading models for rivers and lakes Management of Water Pollution Disposal of wastewater

CE-514 Microbiology Lab

27

Microscopic Examination of Microorganisms Preparation of bacterial smear - staining - Hanging drop technique - plate count test MPN tests and MFT Tests

GROUP lsquoBrsquo SUBJECTS

CE-562 Water Engineering Design

Introduction ndash Sources of water necessity of treatment Critical Water quality parameters water quality guidelines and standards for various water uses

Unit operations ndash principles and design of aeration systems ndash two film theory water in air system air in water system Intake structures ndash Different types design criteria

Principles of sedimentation ndash types of settling and settling equations design criteria and design of settling tanks Principle of Coagulation and Flocculation ndash types of coagulants coagulant aids coagulation theory optimum dose of coagulant design criteria and numerical examples

Filtration - theory of granular media filtration Classification of filters dual and multimedia filtration Adsorption Process Disinfection Water Softening Fluoridation and defluoridation ndash Principles and design Ion Exchange-processes Application Membrane Processes Reverse osmosis Ultrafiltration Electrodyalisis corrosion and corrosion control distribution design of various components of the distribution system

Design of the units of Water Treatment Plant

CE-561 Air Pollution and Control

Definition air pollutants air pollution measurement ambient and at source Effects of air pollution Standards Meteorology Dispersion of air pollutants Air pollution control equipmentsmdashsettling chambers Inertial devices electrostatic precipitator scrubbers fitters adsorption devices combustion devices condensation devices

CE-563 Water Engineering Laboratory

Physical and chemical characteristics of water pH EC Turbidity alkalinity acidity hardness sulphates fluorides nitrates Total solids volatile solids fixed solids Residual chlorine analysis optimum coagulant dose BOD COD Determination of heavy metals in water Total organic carbon CHNS analysis

CE-564 Self Study Open Area Seminar- I

Self Study

GROUP lsquoCrsquo SUBJECTS

CE-611 Wastewater Treatment Design

Treatment objectives Methods and design fundamentals of process analysis Physical unit operations screening flow equalization mixing Physico-chemical Treatment Systems flocculation sedimentation floatation filtration chemical unit processes Biological unit processes Bio kinetics treatment and disposal of sludge Emerging technologies for wastewater treatment and their design

CE-6121 Groundwater and Seepage

28

Darcyrsquos law General hydro-dynamic equations flow nets in isotropic and anisotropic medium

Steady and unsteady flow through confined and non-confined aquifers Schwartz Christoffel transformation and its application for ground water and seepage problems

Multiple well system partially penetrating wells image wells mutual interference of wells

Storage and exploration of ground water design construction and maintenance of wells Ground water recharge and run off Water quality budgeting simulation of ground water basin Application of remote sensing for ground water

CE-6121 Instrumentation

Types of application of measurement instrumentation Generalized configuration and functional description of measu4ring instruments Motion measurement Pressure measurement Flow measurement Environmental Engg Instrumentation

CE-6131 Design of Hydraulic Structures

Project planning site investigations choice of type of dams Cost benefit studies

Non-overflow dams Gravity Arch and buttress type Rock fill and earthen dams their design stress analysis stress concentration around openings

Different types of spillways and energy dissipaters their design Preparation and protection of foundation for dams Model analysis of Hydraulic structures Instrumentation in dams Temperature control in concrete dams

CE-6132 Industrial Waste Water Treatment

Theories of waste water treatments combined treatment of raw industrial waste with domestic sewage Discharge of completely treated waste to Municipal Sewer discharge of raw waste to stream characteristics and treatment of wastes from the apparel industry Food processing industries Material industries Chemical industries Energy industries

CE-614 Air Pollution Laboratory

Experiments using High volume sampler personnel sampler RSPM sampler stack monitoring kit

GROUP lsquoDrsquo SUBJECTS

CE-6611 Global Warming and Climate Change

Energy Issues and Climate Change Alternate Energy Sources Green-House Effect as a Natural Phenomenon Green House Gases GHGs) and their Emission Sources

Quantification of CO2 Emission Global Warming Potential (GWP) of GHGs Modeling Climate change Ozone layer depletion and its control Impacts of climate change ndash Global and India Temperature Rise Sea Level rise Coastal Erosion and landslides Coastal Flooding Wetlands and Estuaries loss

Kyoto Protocol ndash Importance Significance and its role in Climate Change Carbon Trading - Mechanisms

Various Models (European Indian) Global and Indian Scenario Cleaner Development Mechanisms ndash Various Projects related to CO2 Emission Reduction Alternatives of Carbon Sequestration ndash Conventional and non-conventional techniques

29

Role of Countries and Citizens in Containing Global Warming

References

1 Packe and Smith Climate Change

2 Gilbest

CE-6611 Planning and Design of Environmental Services

Planning factors Ventilation and Air conditioning Plumbing Design of Public Bathing Places Lighting Housing with Environmental Perspective

CE-6621 Environmental Planning and Management

Environment and Sustainable Development - carrying capacity relationship with quality of life carrying capacity and resource utilization Engineering Methodology in Planning and its Limitations ndash carrying capacity based short and long term regional planning Environmental Protection - Economic development and social welfare consideration in socio economic developmental policies and planning Total cost of development and environmental protection cost Case studies on Regional carrying capacity Engineering Economics ndash Value Engineering Time Value of Money Cash Flows Budgeting and Accounting Environmental Economics Introduction economic tools for evaluation Green GDP Cleaner development mechanisms and their applications Environmental Audit ndash methods procedure reporting and case studies Total Quality Management in environmental management and protection ndash ISO 9000 14000 and 18000 series of standards

CE-6622 Solid Waste Management

Sources of solid waste types of solid waste methods of disposal of solid waste recycle and reuse problems in the management under Indian conditions

Mechanical Transformation of solid wastes screening size reduction various devices for size reduction objectives

Thermal Transformation of solid wastes pyrolysis incineration gasification

Ultimate disposal of solid wastes Landfills problems location of landfills leachate composition management of leachate landfill liners landfill covers Bio gas from landfills computations of gas quantity and its management

CE-663 Solid Waste and Industrial Wastewater Analysis Lab

Determination of calorific value of different types of wastes Determination of molecular formula using CHNS analyzer Determination of total organic carbon of wastes Determination of moisture content density of wastes

Physical and chemical analysis of wastewater from different industries

CE-664 Minor Project - I

GROUP lsquoErsquo SUBJECTS

CE-7111 Environmental Impact Assessment and Audit

Environmental Impact Assessment ndash Definition Objectives Types ndash Rapid and Comprehensive EIA EIS FONSI Step-by-step procedure for conducting EIA and Limitations of EIA Prevention of Significant Deterioration (PSD) Programme Frame work of Impact assessment scope and contents of EIA methodologies and techniques of EIA

30

Attributes Standards and Value functions Public participation in EIA Environmental Management Plan (EMP) and Disaster Management Plan (DMP) EIA Case Studies ndashThermal Power Plant Mining Fertilizer Construction Projects Air port Water and Wastewater Treatment Plants

CE-7112 Remote Sensing and GIS in Environmental Engineering

Remote Sensing Definition ndash Ideal Remote Sensing System ndash Sensors and Types ndash Remote Sensing Satellite ndash IRS and INSAT specifications ndash Applications of remote sensing ndash DIP Techniques GIS Definition ndash Data and Types ndash Sources of data - Global Positioning System (GPS) ndash Data Structure ndash Types of Analysis ndash Errors ndash Applications of GIS Optimal Routing of Solid wastes using GIS ndash Case Study Environmental Siting of Industries and Zoning Atlas Development Re-modeling of Water Distribution System using GIS ndash Case Study Sustainable Urban Development Planning using GIS Environmental Degradation Assessment using RS and GIS Ground water vulnerability modeling using GIS

CE-7121 Air Quality Modeling

Introduction to air pollution modeling Approaches to model formulation Model Classification Criteria for model selection Air pollution meteorology ndash meteorological parameters stability classification plume rise plume behavior dispersion parameters Basic diffusion equation deterministic numerical and statistical modeling approach Introduction to boundary layer turbulence Physical modeling approach stochastic modeling approach to air pollution dispersion Theory of Gaussian plume model and its application Introduction to indoor air quality models ISCST3 CALINE4 ROADAIR Case studies

CE-7122 Hazardous Waste Management

Introduction Sources Classification Regulations for Hazardous Waste Management Hazardous Waste Characterization Designated Hazardous Wastes Waste Minimization and Resource Recovery ndash Approaches Development of a Waste Tracking System Selection of waste Minimization Process Case Studies Transportation of Hazardous Waste ndash requirements regulations containers bulk and non-bulk transport Emergency Response Physico-chemical Chemical and Biological Treatment of hazardous waste Thermal treatment - Incineration and pyrolysis Sanitary landfill ndash design approach leachate and gaseous collection system Facility Siting and Process Selection for treatment storage disposal facility (TSDF) Soil contamination and site remediation ndash bioremediation processes monitoring of disposal sites

CE-7123 Occupational safety and Health

Introduction Occupational Safety and Health Act Occupational Safety and Health Administration Right to know Laws Indian Acts ndash Labour Act Factories Act OSHA Accident ndash Causation investigation methods and different models Ergonomics ndash need Task Analysis Preventing Ergonomic Hazards Ergonomics Programme Occupational Hazard and Control - Hazard Analysis Human Error and Fault Tree Analysis Emergency Response Hazards and their control in different manufacturing and processing industries Fire Prevention and Protection - types of Fire Fire Development and its Severity Effect Extinguishing Fire Electrical Safety Product Safety Occupational Health - Health and Safety Considerations Personal Protective Equipment Health problems in different types of industries ndash construction textile steel and food processing pharmaceutical occupational Health and Safety considerations in Wastewater Treatment Plants

CE-713 Self study Open Area Seminar II

CE-714 Minor Project II

CE-715 Major Project Part-I

GROUP lsquoFrsquo SUBJECTS

CE-811 Major Project Part II

Syllabus for M Tech (Hydraulics and Water Resources Engineering)

Scheme for MTech ( Hydraulics and Water Resources Engineering)

Sem

Gro

up

Course details Course

Code

L T P Internal

Marks

External

Marks

Total

Marks

Credit

s

A Advanced Mathematics CE 531 3 0 0 50 100 150 3

I Advanced Hydrology CE 532 3 0 0 50 100 150 3

Advanced Open Channel Hydraulics CE 533 3 0 0 50 100 150 3

Hydraulic Engg Lab-1 CE 534 0 0 2 30 70 100 2

B Advanced Fluid Mechanics CE 581 3 0 0 50 100 150 3

Water Power Engineering CE 582 3 0 0 50 100 150 3

Hydraulics Engg Laboratory-II CE 583 0 0 2 30 70 100 2

Self study open area seminar-I CE 584 0 0 2 50 0 50 1

21Hoursweek 1000 20

II

C Planning amp management of Water Resources CE 631 3 0 0 50 100 150 3

Elective ndashI any one of the following

Ground water Hydrology

Coastal Engg

Hydrometeorology

CE 6321

CE6322

CE 6323

3 0 0

50 100 150 3

Elective ndash II any one of the following

Design of Hydraulic structures

Advanced irrigation and drainage Engg

Water pollution control and stream pollution

CE 6331

CE 6332

CE 6333

3 0 0

50 100 150 3

Hydraulics Engg Laboratory-III CE 634 0 0 2 30 70 100 2

D Elective ndash III any one of the following

Application of Geotech Engg And GIS in water

resources

River mechanics and sediment transport

Urban storm water drainage

CE 6811

CE 6812

CE 6813

3 0 0

50 100 150 3

Elective ndash IV any one of the following

Design of flood control and river training works

Water Resources Economics

Hydrodynamics stability

CE 6821

CE 6822

CE 6823

3 0 0

50 100 150 3

Hydraulic Engg Lab- IV CE 683 0 0 2 30 70 100 2

Minor project -I CE 684 0 0 2 50 00 50 1

21Hoursweek 1000 20

III E Elective ndash V any one of the following

Environmental Impact Assessment

Subsurface investigations

Water and soil conservation Engg

CE 7311

CE 7312

CE 7313

3 0 0

50 100 150 3

Elective ndash VI any one of the following

System Techniques in Water Resources Engineering

Computational Hydraulics

Hydro Informatics and Simulations

CE 7321

CE 7322

CE 7323

3 0 0

50 100 150 3

Self Study open area Seminar CE733 0 0 2 100 00 100 2

Minor Project ndash II CE 734 0 0 4 0 300 300 6

Major Project ndash I CE 735 0 0 6 200 00 300 6

18 HrsWeek 1000 20

IV F Major Project ndash II CE 831 0 0 6 00 1000 1000 15

6 Hrswk 1000 15

Grand Total 3500 70

ADVANCED MATHEMATICS

Paper Code L T P Cr

CE 531 3 0 0 3

Numerical method Finite Differences Numerical integration and differentiation Numerical solution of ordinary

differential equations and their application to engineering structures Poissonrsquos Laplacersquos and bi-harmonic

equations Relaxation methods and their application to Civil Engineering problems Complex variables Conformal

mapping and Swartz-Christoffel transformation applied to flow problems

Statistics and Probabilities Statistical parameters Discrete and continuous distributions frequency analysis

confidence limits Regression and correlation Stochastic modelling and Time series analysis Chi-square test of

goodness of fit Sensitivity analysis and decision making

Advanced Computer programming techniques and their applications to Engineering problems

Optimization techniques using Linear Non-linear and dynamic programming

ADVANCED HYDROLOGY

Paper Code L T P Cr

CE 532 3 0 0 3

Review of basic principles of hydrology Concepts of linear and non-linear modelling in rainfall-Runoff models

Probability and statistical analysis in hydrology correlation and regression analysis Lumped and distributed flood

routing methods Flood estimation methods

Time Series Analysis

Synthetic data generation Simple and multiple linear regression

At site frequency analysis

Analysis of low flows

Stream flow forecasting

Introduction to stochastic modelling and time series analysis

ADVANCED OPEN CHANNEL HYDRAULICS

Paper Code L T P Cr

CE 533 3 0 0 3

Energy and momentum equation Effect of Non-uniform velocity distribution

metering of flow Hydraulic Jump Formations of jump in expanding and contracting channel jump type jump

control jump on sloping floors Gradually varied steady flow and rapidly varied steady flow in open channels

surface profiles in GVF-analysis different method of computations Chowrsquo-s methods standard step method finite

difference method Unsteady Flow Waves celerity of wave boundary conditions standing and progressive wave

positive and negative surges Dam break problem deep water group velocity solitary wave Introduction to Fluvial

hydraulics sediment transport

HYDRAULIC ENGINEERING LAB I

Paper Code L T P Cr

CE 534 0 0 2 2

I) Computation of energy momentum correction factors by use of current meter and pitot tube

II) Calibration of weir and venturi-flumes determination of modular limit

III) Normal critical and brink depth-their experimental Verification and determination of Manningrsquos n

IV) Backwater profiles

V) Hydraulic jump characteristics

VI) Bed formations Threshold condition in sediment transport

ADVANCED FLUID MECHANICS

Paper Code L T P Cr

CE 581 3 0 0 3

Review of basic laws of fluid flow in integral and differential form kinematics Ideal fluid flow Newtonian fluid

flow and applications Creeping flow Two dimensional Flow Patterns Sink and Source Laplace equation solution

by Graphical method Theoretical concepts of boundary layer Boundary layer theory Turbulent boundary layer

Boundary Layer Separation and its Stability Transition turbulence analysis and Measurement Correlation and

Statistical Theories Fundamentals of compressible flows Modelling and dimensional analysis

WATER POWER ENGINEERING

Paper Code L T P Cr

CE 582 3 0 0 3

Comparative study of Hydro-Thermal and Nuclear Projects Investigations of Hydro-electric projects-types of

development nature of demand and supply interconnection pondage and storage

Design of intakes gates air inlet valves penstocks and anchor blocks Power canals Forebay

Type of turbines their selection Design of turbine components like scroll casing runner draft tube governing of

turbine

Characteristics and model studies of turbines

Water hammer phenomenon physical interpretation water hammer studies by different methods for sudden and

gradual closure of valve

Surge tanks governing equation for analysis stability calculation of surge by different methods surge in power

canals surge control Design principles of Power House

HYDRAULIC ENGINEERING LABORATORY II

Paper Code L T P Cr

CE 583 0 0 2 2

Flow visualisation studies Boundary layer drag and lift on immersed bodies Measurement of turbulent

quantities) some experiments on wind tunnel

PLANNING AND MANAGEMENT OF WATER RESOURCES

Paper Code L T P Cr

CE 631 3 0 0 3

Principles of engineering economics discounting techniques un-certainity planning horizon Selection of optimal

alternatives Application of linear non linear and dynamic programings in water resources Optimal sequencing and

scheduling of resources Planning of water resources projects cost ndashbenefit analysis for irrigation water power and

floods control projects

Principles and practice of water resources planning and management Purposes water resources developments

Engineering economy in water resources planning

Reservoir planning river basin development Factors affecting irrigation and power development examples of

multipurpose project in India

Storage and related problems optimum storage Rule curve minimum storage and its effect on the cost of power

Computer applications in the designs of water resources systems Water shed management Management of reservoir

operations

GROUND WATER HYDROLOGY

Paper Code L T P Cr

CE 6321 3 0 0 3

Introduction Steady and unsteady flow through confined and unconfined aquifers Schwartz-Christoffel

transformation and its application for ground water flow and seepage problems Numerical Techniques for solution

of ground water flow

Ground water movement Darcyrsquos law permeability hydraulic conductivity ground water in perforated regions

Isotropic and anisotropic aquifers and general flow equations Multiple well system partially penetrating wells

image wells mutual interference of wells

Ground water modeling techniques Porous media models analog models and digital computer models

Investigations of ground water Surface and subsurface investigation of ground water Water level measurement

fluid conductivity Storage and exploration of ground water Design Construction and Maintainence of wells

simulation of ground water basin Application of remote sensing for ground water

Artificial recharge of ground water Concept of artificial recharge re-charge methods recharge on water

spreading recharge mound and induced recharge General hydro-dynamic equations flow nets in isotropic and

anisotropic medium Water harvesting and legislation

COASTAL ENGINEERING

Paper Code L T P Cr

CE 6322 3 0 0 3

Definition-wave classification-linear theory of waves-assumptions and derivations of relationship of wave

characteristics-pressure within a progressive wave wave energy energy flux-wave decay-Transformation of waves-

Fundamental aspects of stokes theory

Reflection Refraction Diffraction of wave-Breaking of waves-types criterion and importance of breaking- wave

force on structure-vertical sloping curved and stepped barrier-force due to non-breaking breaking and broken

waves-Force on piles

Need for forecasting- SMB and PNJ methods of wave forecasting

Origin and classification of tides Karwinrsquos equilibrium theory of tides-effects on structure-seiches and tsunamis

Types of sediment and movement-types of beaches and beach profile Long Shore drift and its engineering

significance Causes of coastal erosion and methods of protection Introduction to outfall design necessity and few

design examples

HYDROMETEOROLOGY

Paper Code L T P Cr

CE 6323 3 0 0 3

Atmosphere General Circulation Composition and Structure of Atmosphere Role of

Meteorology in Hydrology

Precipitation Process ndash Adiabatic Process Stability and Instability of Atmosphere

Atmosphere Thermodynamics

Clouds ndash Classification Formation and Characteristics

Climate Preparation of Climatological norms and Climate Classification

Weather Charts Preparation Analysis and Interpretation Weather Forecast

Monsoon ndash Monsoon Circulation Monsoon Troughs Monsoon Depression and Tropical

Cyclones

Hydro-meteorological Instrumentation and Observations

Use of Radar and Satellites in Hydrology

Storm Analysis Storm Selection Storm Maximization Probable Maximum Precipitation

Meteorological Homogeneity Storm Transposition

Computer applications in the design of hydraulic structures

DESIGN OF HYDRAULIC STRUCTURES

Paper Code L T P Cr

CE 6331 3 0 0 3

Design of spillways energy dissipation below spillways and their construction management

Non-overflow dams Gravity Arch and buttress dams rock fill and earthen dams their design and management at

the site Stress analysis stress concentration around openings Model analysis of hydraulic structures

Design of weirs on permeable foundation silt excluders and different types of silt ejectors and construction

management of diversion head works Case studies of large dams

Foundations design well foundation coffer dams drilled shafts and piled foundations Stability analysis

construction maintenance and testing of foundations Codal provisions for foundation design of these structures

ADVANCED IRRIGATION AND DRAINAGE ENGINEERING

Paper Code L T P Cr

CE 6332 3 0 0 3

Basic Irrigation Development Problems Types of development water rights and disputes Land classification and

development Investigation for irrigation planning water resources conjunctive use of surface and ground water

reclamation of sewage and drainage flow Recharging of groundwater by flood flows

Water requirement of crops Consumptive use depth and frequency of irrigation cropping pattern

Modern methods of irrigation their economics and design irrigation network and irrigation structures Management

of irrigation analysis of existing irrigation projects irrigation losses and wastes irrigation efficiency control and

maintenance of irrigation works

Problems of water logging-salinity and alkalinity land drainage problems- design of surface and sub-surface

drainage system reclamation

Systems approach in planning of irrigation and drainage projects

WATER POLLUTION CONTROL AND STREAM SANITATION

Paper Code L T P Cr

CE 6333 3 0 0 3

Water quality and stream quality standards

Organic self purification-quantitative definition-re-oxygenation-oxygen balance and stream

dissolved oxygen profile-oxygen sag curve-Streeter Phelprsquos equation-Critical deficit problems

Microbial self purification-pathogenic microorganisms of sewage origin-indices of

contamination-enumeration-per-capita contribution-seasonal variations-death rate survival in

the stream environment

Classification of streams-natural self purification process-disposal of wastewater Rational

stream sanitation practices-dual objectives of stream sanitation practices-the science

and art of applied stream sanitation-stream survey-types of stream survey-execution of stream

surveys

Purification in estuaries-evaluation of self purification in estuaries-tides and currents distribution

of waste loads by tidal translation-sea water intrusion-waste assimilation capacity

of estuaries-bacterial contamination-stable wastes

Case studiessimulation studies water quality modelling using qual2E WASP

HYDRAULICS ENGG LABORATORY-III

Paper Code

L T P Cr

CE 634 0 0 2 2

Experiments based on models studies in irrigation engineering river mechanics river flow dynamics and sediment

transport Experiments on instrumentation techniques

APPLICATION OF GEOTECH ENGG AND GIS IN WATER RESOURCES

Paper Code

L T P Cr

CE 6811 3 0 0 3

Introduction sources of energy electromagnetic spectrum electromagnetic radiation reflection transmission and

absorption Interaction of EMR with atmosphere scattering refraction absorption transmission atmospheric

windows Brief review of thermal and microwave remote sensing their utility merit and demerits Introduction

geographical concepts and terminology difference between image processing system and GIS utility of GIS

Various GIS packages and their salient features essentials components of GIS data acquisition through scanners

and digitizers Raster and vector data introduction descriptions raster and vector data raster versus vector raster

to vector conversion remote sensing data in GIS

Introduction importance of water resources and hydrology components of water resources hydrological cycle role

of remote sensing Geo-morphological analysis of watershed determination of various geo-morphometric

parameters using conventional and remote sensing data digital elevation model data input interpolation

techniques surface generation assessment of accuracy extraction of various watershed parameters Irrigation water

management and scheduling performance evaluation of irrigation command areas performance indicators mapping

of irrigation command areas using temporal remote sensing data Flood plain identification and management use of

remote sensing data products digital based extraction of flood plain parameters and indices drought identification

and management conventional approach data requirements and methods drought Indices and its assessment using

remote sensing data

RIVER MECHANICS AND SEDIMENT TRANSPORT

Paper Code L T P Cr

CE 6812 3 0 0 3

River morphology river systems hydraulics regime and dynamics Theory of meandering Inter relationship

between river dimensions sediment load and water flow River response to river training works Local scour around

hydraulic structures Density currents and sedimentation of reservoirs

Introduction sediment properties threshold conditions for uniform sediments exposure and sheltering effects in

non-uniform sediments critical-tri-active stress of non-uniform cohesion-less sediments and cohesive soil regimes

of flow analysis of ripples dunes and anti-dunes resistance to flow and velocity distribution in alluvial streams

Bed load suspended load and wash load computation of bed load for uniform and non uniform sediments

Mechanism of suspension distribution of suspended load computation of suspended load and total load

URBAN STORM WATER DRAINAGE

Paper Code L T P Cr

CE 6813 3 0 0 3

Hydraulics of closed and open drains under different flow conditions unsteady steady and spatially varied flows

Design criteria of drains based on hydraulic considerations

Hydrologic design scale selection of design level Risk analysis of safety margins and safety factors

Design storms precipitation depth intensity duration frequency relationships Design hyetographs from storm

events

Design flows storm sewer design Codal requirements for storm water drainage

DESIGN OF FLOOD CONTROL AND RIVER TRAINING WORKS

Paper Code L T P Cr

CE 6821 3 0 0 3

Basic causes of flood Flood prone areas in India and their problems case history of some important river basins of

India Engineering and administrative methods of flood plane regulation Economic aspects of flood control

schemes cost benefit analysis Flood forecasting flood warning and flood fighting

Morphological study of river behaviour Theories of river meandering and river regimes Necessity principles and

methods of river training Case history of river training works in India and abroad Design of Levees Groynes Cut-

offs and Guide bunds etc River training works for different hydraulic structures

WATER RESOURCE ECONOMICS

Paper Code L T P Cr

CE 6822 3 0 0 3

Principles of engineering economics discounting techniques un-certainity planning horizon Selection of optimal

alternatives Application of liner non-linear and dynamic programmings in water resources Optimal sequencing

and scheduling of resources Planning of water resources projects cost- benefit analysis for irrigation water power

and flood control projects

HYDRO DYNAMIC STABILITY

Paper Code L T P Cr

CE 6823 3 0 0 3

Control volumes and system approach- Stokersquos Gauss and Greenrsquos theorem and applications

Conservation of mass momentum moment of momentum and energy equations

Potential flows Basic flow patterns combination of flow patterns application to civil engineering problems

Conformal transformation Viscous flow Navier-Stokersquos equations Exact and approximate solutions

Boundary layer theory Boundary layer equations and its solution boundary layer separations and its control theory

of stability drag on immersed bodies

Formulation of hydrodynamic stability problems in various situations of flows and particularly for parallel flows

Waves and allied experimental studies Study of laminar to turbulent transition

CE 683 HYDRAULIC ENGINEERING LAB ndashIV

Paper Code L T P Cr

CE 683 0 0 2 2

Application of CAD in hydraulic Engineering Two and three dimensional analysis of gravity dams Seepage and

stability analysis of embankment Design of weirs on permeable foundations Design of canals and transitions

Design of gates and valves Design of pipe networks

ENVIRONMENTAL IMPACT ANALYSIS FOR WATER RESOURCE PROJECTS

Paper Code L T P Cr

CE 7311 3 0 0 3

Objectives of environmental impact assessment methodology for EIA Baseline study scooping checklist scaled

and weighted matrices networks overlays index methods Prediction and Assessment of impacts on air water land

demography and Biological Environment Impact analysis of Hydro power different case studies environmental

Impact Analysis-Laws and Status in India Rehabilitation and resettlement

Identification of process operation imbalances resulting in resources loss and their impact on environment

SUBSURFACE INVESTIGATIONS

Paper Code L T P Cr

CE 7312 3 0 0 3

Introduction amp broad classification of subsurface methods

Direct Methods

Excavation amp Pitting

Well Drilling Techniques

Drill Stem Testing

Geological Well Logs

Indirect Methods

Geophysical Well Logging Electrical Well logging methods Normal amp Lateral Resistivity

Logs Self Potential Logs Induction amp Micro focused logs electrical logging practices

evaluation of aquifer parameters

Radiation logging (Natural gamma neutron amp gamma gamma logging) - Acoustic logs

Caliper logs amp Dip-meter surveys amp their applications in groundwater

prospecting

WATER AND SOIL CONSERVATION ENGINEERING

Paper Code L T P Cr

CE 7313 3 0 0 3

Water conservation Rain water harvesting techniques water shed development ground water recharging check

dams reservoirs and aquifers control of infiltration seepage and evaporation control of effluent and waste water

disposal control of agricultural run off and siltation Plan utilisation of water resources flood planes zone

management reuse and recycling of treated waste water effluent irrigation

Soil Conservation Introduction to soil erosion mechanisms and its causes and control sheet erosion rill erosion

gully erosion control of erosion by bunding terracing contour trenching gully stabilizing check dams drop

spillways chute spillways grass land management and forest management reclamation of saline and usher soils

remediation of contaminated soils Case studies on soil and water conservation practices

SYSTEM TECHNIQUES IN WATER RESOURCES ENGINEERING

Paper Code L T P Cr

CE 7321 3 0 0 3

System Concepts

System concepts definitions needs for system approach different types of

system parameters and variables

Linear Programming

Revision Big M Method duality sensitivity analysis Application of Linear

Programming for Hydraulics amp Water Resource

Non Linear Programming

Unconstrained one Dimensional search methods Dichotomous search method

Fibonacci Golden section multivariable unconstrained gradient techniques

steepest ascent and descent methods Newtonrsquos methods Application of

Dichotomous search method Fibonacci amp Golden section to the various sectors of

Water Resource Engineering FP methods constrained Lagrangian multiplier

techniques Kuhn Tuckerrsquos conditions penalty function methods

Dynamic Programming

Principle of optimality recursive equations Application of Dynamic

programming to Water Resource Engineering

Stochastic Methods

Queuing theory simulation technique sequencing model Morkovrsquos process

Capitalisation

Annuity benefit-cost analysis Benefit Cost Analysis for multi purpose water

resource projects

Geometric Programming

Polynomial unconstrained minimization problem arithmatics geometric

unequality solution of unconstrained geometric programming constraints

minimization geometric programming with mixed inequality constrained

Games Theory

COMPUTATIONAL HYDRAULICS

Paper Code L T P Cr

CE 7322 3 0 0 3

Introduction to finite element and finite volume techniques in computational fluid dynamics

Numerical solution of Navier-Stokersquos equation and boundary layer equation Reynoldrsquos equation-turbulence

modelling

Separated flows transient flow through pipes surge tanks steady uniform and non-uniform flow through open

channels

Spatially varied flow Numerical solutions unsteady flow through open channels

Application of finite element method in other areas of water resources eg Multiphase flow estuarine and lakes

oceans waves tidal flow etc Specification related to storm water drainage

HYDROINFORMATICS AND SIMULATIONS

Paper Code L T P Cr

CE 7323 3 0 0 3

Introduction

Concept of hydro-informatics scope of internet and web based modelling in water

resources engineering

Introduction to multi criterion decision support system ndash Components for

modelling software

Introduction to Simulation

Different simulation techniques ndash Applications of simulation techniques in

hydraulics

Introduction to Artificial Neural Networks

Networks and its training-Back propagation algorithm Conjugate gradient

algorithm Cascade correlation algorithm Applications of ANN in WRE Genetic Algorithm (GA)

Concept Basic principle of GA Working principle of GA Coding Fitness

function GA Operations Reproduction Cross over Mutation Applications of

GA in Water Resources Engineering

DELHI TECHNOLOGICAL UNIVERSITY

SCHEME OF EXAMINATION

AND

COURSE OF READING

FOR

MTech (Software Engineering)

Syllabus applicable to the students seeking admission to

MTech (Software Engineering) Course

SCHEME

Paper

No

Subject Code

No

Title of the Course Internal

Marks

External

Marks

Total

Marks

Credits Semester

Total

1

2

3

4

GROUP A CO 511

CO 512

CO 513

CO 514

Software Engineering Methodologies

Data Warehousing amp Data Mining

Advances in Internet amp Web

Technologies

Software Engineering Lab

50

50

50

30

100

100

100

70

150

150

150

100

3

3

3

2

1000

(20

credits)

5

6

7

8

GROUP B

CO 561

CO 562

CO 563

CO 564

Software Project Management Artificial Intelligence and Expert Systems

Artificial Intelligence Lab

Self-study Open Area Seminar-I

50

50

30

50

100

100

70

-

150

150

100

50

3

3

2

1

9

10

11

12

GROUP C CO 611

CO 612

CO 613

CO 614

Software Validation Verification amp

Testing

Elective-I

Elective-II

Software Testing Laboratory

50

30

50

50

100

70

100

100

150

100

150

150

3

2

3

3

1000

(20

credits)

12

13

14

15

GROUP D

CO 661

CO 662

CO 663

CO 664

Elective-III

Elective-IV

Lab based on Electives

Minor Project-I

30

50

50

50

70

100

100

-

100

150

150

50

2

3

3

1

16

17

18

19

20

GROUP E

CO 711

CO 712

CO 713

CO 714

CO 715

Elective-V

Elective-VI

Self-study Seminar ndashII

Minor Project-II

Major Project-I

50

50

100

-

-

100

100

-

300

300

150

150

100

300

300

3

3

1

4

4

1000

(15

credits)

21 GROUP F CO 811

Major Project-II

-

1000

1000

15

1000

(15

credits)

List of Electives

Electives I (Group C) Any one subject can be chosen from the following

Software Requirements Engineering

Software Quality amp Metrics

Bio-Informatics

Advances in Information Systems

Modeling and Simulation

Electives II (Group C) Any one subject can be chosen from the following

Real-Time Systems

Quantum Computing

Recent Trends in Distributed Systems

Cluster amp Grid Computing

Pervasive Computing

Electives III (Group D) Any one subject can be chosen from the following

Virtual Reality

Advances in Multimedia Systems

Wireless amp Mobile Communication

Data Security and Cryptography

Fault Tolerant System Design

Electives IV (Group D) Any one subject can be chosen from the following

Digital Image Processing

Neural Networks amp Fuzzy Logic

Biometrics

Robotics Engineering

Pattern Recognition

Electives V (Group E) Any one subject can be chosen from the following

Advances in Software Engineering

Software Architecture amp Design Patterns

Component Based Technology

Intellectual Property Rights

Human Computer Interface

Electives VI (Group E) Any one subject can be chosen from the following

Natural Language Processing

Computer Vision

Machine Learning

Semantic Web

Information Retrieval

First Year MTech (SE) I Semester

CO 511 Software Engineering Methodologies

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Review of Software Engineering Principles amp Techniques Discussion on System

Development amp Methodologies Object-Oriented System Development

Unit 2 Software Engineering Processes Introduction to Object Oriented Paradigm Object-

Oriented Process Models Rational Unified Process (RUP)

Unit 3 Methodologies Yourdon method for software design Modified Yourdon Method

Object Modeling Technique (OMT) of Rumbaugh

Unit 4 Unified Modeling Language (UML) UML diagrams such as use case diagrams class

diagram sequence diagrams state transition diagrams etc

Unit 5 Agile development methodologies

Unit 6 Applications A complete case study of Software development using above

Methodologies Concepts of Computer-Aided Software Engineering

Tools Knowledge about current CASE tools used in the industry

Suggested Readings-

Text Books

1 Ian Sommerville ldquoSoftware Engineeringrdquo 7th Edition Addison-Wesley 2004ISBN 81-

7758-530-4

2 Roger S Pressman ldquoSoftware Engineering ndash A Practitionerrsquos Approachrdquo - 4th edition

McGraw Hill Publications

3 Grady Booch James Rambaugh Ivar Jacobson ldquoUnified Modeling Language Users

Guiderdquo 2nd Edition Addison- Wesley ISBN ndash 0321267974

Reference Books

1 Ivar Jacobson Grady Booch James Rumbaugh ldquoThe Unified Software Development

Processrdquo Pearson Education

2 Yourdon ldquoModern Structured Analysisrdquo PHI

3 KK Aggarwal and Yogesh Singh ldquoSoftware Engineeringrdquo New Age Publications 2009

CO 512 Data Warehousing amp Data Mining

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Data Warehousing - Basic concepts in data warehousing Collecting the requirements

of data warehouse Data Warehouse Architecture Design Implementationamp Maintenance

OLAP in data warehouse Data warehousing and the web Further Development of Data Cube

Technology From Data Warehousing to Data Mining

Unit 2 Data Mining Concepts Data mining primitives Basics of data mining Query language

Designing GUI based on a data mining query language Architectures of data mining systems

Unit 3 Mining Association Rules in Large Databases Association Rule Mining Mining

Single Dimensional Boolean Association Rules from Transactional Databases Mining

Multilevel Association Rules from Transaction Databases Mining Multidimensional Association

Rules from Relational Databases and Data Warehouses From Association Mining to Correlation

Analysis Constraint Based Association Mining

Unit 4 Classification and Prediction Issues Regarding Classification and Prediction

Classification by Decision Tree Induction Bayesian Classification Classification by

Backpropagation Classification Based on Concepts from Association Rule Mining Other

Classification Methods Prediction Classifier Accuracy

Unit 5 Cluster Analysis in Data Mining Types of Data in Cluster Analysis A Categorization

of Major Clustering Methods Partitioning Methods Density Based Methods Grid Based

Methods Model Based Clustering Methods Outlier Analysis

Unit 6 Mining Complex Types of Data Multidimensional Analysis and Descriptive Mining of

Complex Data Objects Mining Spatial Databases Mining Multimedia Databases Mining Time

Series and Sequence Data Mining Text Databases Applications Systems products and research

prototypes Additional themes in data mining Trends in Data mining spatial mining and Web

Mining Web concept mining Web structure mining Web Usage mining

Suggested Readings-

Text Books

1 PPonnian ldquoData Warehousing Fundamentalsrdquo John Wiley

2 MHDunham ldquoData Mining Introductory amp Advanced Topicsrdquo Pearson Education

3 HanKamber MKaufman ldquoData Mining Concepts amp Techniquesrdquo

Reference Books

1 Ralph Kimball ldquoThe Data Warehouse Lifecycle Tool Kitrdquo John Wiley

2 MBerry GLinoff ldquoMaster in Data Miningrdquo John Wiley

3 WHInmon ldquoBuilding the Data Ware housesrdquo Wiley Dreamtech

CO 513 Advances in Internet amp Web Technologies

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Emergence of the Internet Basics notions amp working parts of the Internet E-Mail file

transfer telnet Usenet gopher wais Archie and veronica Internet chat

Unit 2 Web Development Developing Web using HTML XML ASP Concepts of Web

Programming using Scripting Languages such as JavaScript CGI PHP etc Database

Connectivity with MySQL and JDBC

Unit 3 Web Research amp Practices The World Wide Web Impact Opportunities and

Challenges Evolution of Search Engines

Unit 4 Web Search amp Mining Framework Supporting Technologies concepts applications

types amp tools Quantifying the Web

Unit 5 Crawling Techniques The task of a web crawler Crawler algorithms Indexing

techniques Ranking in Web

Unit 6 Advanced Research Topics Duplicate Detection Contextual Search etc

Suggested Readings-

Text Books

1 Raj Kamal ldquoInternet and Web Technologiesrdquo Tata McGraw Hill edition

2 Mark Levene ldquoAn Introduction to Search Engines and Web Navigationrdquo Pearson

Education ISBN 0321306775

3 Soumen Chakrabarti ldquoMining the Web Discovering Knowledge from Hypertext

Datardquo Morgan-Kaufmann Publishers ISBN 1-55860-754-4

Reference Books

1 Wendy Willard ldquoHTML A Beginnerrsquos Guiderdquo Tata McGraw-Hill

2 Chris Bates ldquoWeb Programming building internet applicationsrdquo 2nd edition Wiley

Dreamtech

3 Sebesta ldquoProgramming World Wide Webrdquo Pearson

4 Ullman Larry ldquoPHP and MySQL for Dynamic Web Sitesrdquo Peachpit Press

5 Pierre Baldi Paolo Frasconi Padhraic Smyth ldquoModeling the Internet and the Webrdquo John

Wiley and Sons Ltd ISBN 0470849061

CO 514 Software Lab

Practical - 2 Hrs per week Practical - 100 Marks

Software Lab based on using latest CASE Tools At least one Minor Project to be developed for

an application based on methodologies covered in the course

CO 561 Software Project Management

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introduction Project Management concepts Process Framework Project Planning

Software Life Cycle Models Artifacts of the Project Management Process

Unit 2 Cost and Scheduling Estimation Models Various Levels of COCOMO for Cost

Effort Schedule and Productivity Estimation Approaches to Effort Cost Estimation and

Schedule Estimation factors through COCOMO II Putnam Estimation Model Algorithmic

models

Unit 3 Project Management Techniques Project Organizations and Responsibilities

Establishing Project Environment Risk Management Process Project Tracking and Control

Defect Tracking Concepts such as Process monitoring and audit Reviews Inspections and

Walkthroughs

Unit 5 Risk Estimation What is Risk Framework for Managing Risks Risk Identification

Risk Analysis and Prioritization Risk Avoidance and Mitigation Strategies Risk Monitoring

Estimating

Unit 4 Activity Planning including CPM and PERT Network planning model Activity-on-

arrow network Precedence network Forward pass Backward pass Critical path Slack and

float

Unit 6 Advance Topics in Software Project Management Discussion on future Software

Project Management Practices amp Modern Project Profiles Next Generation Software Economics

Modern Process Transitions

Suggested Readings-

Text Books

1 Watts S Humphrey ldquoManaging the Software Processrdquo Pearson Education

2 Walker Royce ldquoSoftware Project Managementrdquo Pearson Education

3 Pankaj Jalote ldquoSoftware Project Management in Practicerdquo Pearson Education

Reference Books

1 Bob Hughes ldquoSoftware Project Managementrdquo TMH

2 Chris Kemerer ldquoSoftware Project Management Readings and Casesrdquo

CO 562 Artificial Intelligence amp Expert Systems

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introduction The AI Problems AI Techniques Basic Problem solving methods state

space search problem characteristics Production systems characteristics issues in design of

Intelligent search algorithm

Unit 2 Heuristic search Techniques Hill climbing techniques Best First search Problem

Reduction Constraint Satisfaction Means-End Analysis

Unit 3 Knowledge Representation Knowledge Representation issues Knowledge

Representation using Predicate logic Semantic Nets Semantic Frames Conceptual Dependency

scripts Knowledge representation with uncertainty

Unit 4 Programming Languages Fundamental and concepts of Programming languages like

Prolog or Lisp Relationship of languages with Knowledge representation and inferences

Unit 5 Expert Systems What and Why of expert systems Structure of an Expert system

interaction with an expert system Design of an Expert system implementing expert system shell

Expert System Development techniques amp tools with Case Study Construction of Programs

using different data structure

Unit 6 Advanced topics Applications of AI in Game Playing amp Natural Language Processing

Concepts of Fuzzy Logic Introduction to Intelligent Agents

Suggested Readings-

Text Books

1 Artificial Intelligence E Rich and K Knight TMH 2nd ed 1992

2 Introduction to Expert Systems Peter Jackson AWP MA 199

3 Introduction to AI and Expert Systems DW Patterson PHI 1992

Reference Books

1 Artificial Intelligence - an Engineering Approach RJ Schalkoff McGraw Hill Int

Ed Singapore 1992

2 Principles of AI NJ Nilsson Narosa Publ House 1990

3 Artificial Intelligence Structures and Strategies for Complex Problem Solving (5th

Edition) George F Luger 2005 Addison-Wesley ISBN-10 0321263189

4 Artificial Intelligence A Guide to Intelligent Systems (2nd Edition)Michael

Negnevitsky 2005 Addison-Wesley ISBN-10 0321204662

CO 563 Artificial Intelligence Lab

Practical - 2 Hrs per week Practical - 100 Marks

Objective of the course - To develop intelligent systems in different engineering domains like

Games Theorem Proving Natural Language Processing etc

CO 564 Self-study Open Area Seminar-I

Practical - 2 Hrs per week Sessional - 50 Marks

Objective of the course - Students should explore the research areas amp industry practices in the

field of Software Engineering Artificial Intelligenceamp other applied areas The students will

submit a symposium on the topics selected

First Year MTech (SE) II Semester

CO 611 Software Validation Verification amp Testing

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introductory concepts Verification ampValidation Terminologies like Goals Role

Objectives Limitations Approaches amp Applicability

Unit 2 Software Testing Testing Process Limitations of Testing Testing activities

Unit 3 Levels of Testing Unit Testing Integration Testing System Testing

Debugging Domain Testing Regression Testing Slice based testing

Unit 4 Software Testing Techniques Detail study of Functional Testing Structural Testing

Object Oriented Testing

Unit 5 Software Testing Tools Taxonomy Methodology to evaluate automated testing Using

tools Load Runner Win runner and Rational Testing Tools Java Testing Tools JMetra JUNIT

Cactus and other recent tools

Unit 6 Advanced Topics on Testing Prioritizing the Test-cases Web Applications Testing

Off-the-shelf component testing security testing Data-warehouse Automated test data

generation

Suggested Readings

Text Books

1 Paul C Jorgenson Software Testing A Craftsmanrsquos approach CRC Press 1997

2 Desikan Ramesh Software Testing principles and Practices Pearson Education

Reference Books

1 William E PerryEffective Methods for Software Testing John Wiley

2 Steven R Rakitin Software Verification and Validation for Practitioners and Managers

2nd edition Artech House

3 Boris Beizer ldquoSoftware Testing Techniquesrdquo Second Volume Second Edition Van

Nostrand Reinhold New York 1990

4 Louise Tamres ldquoSoftware Testingrdquo Pearson Education Asia 2002

5 Boris Beizer ldquoSoftware System Testing and Quality Assurancerdquo Van Nostrand einhold

New York 1984

6 Glenford Myers ldquoThe Art of Software Testingrdquo John Wiley amp Sons Inc New York

1979

CO 612 Software Testing Lab

Practical - 2 Hrs per week Practical - 100 Marks

Objectives of the course -Software Testing Lab where hands-on experience on various Testing

Tools A project development for an application using these tools

Elective I Group C

Lectures - 3 Hrs per week Theory - 150 Marks

CO 613

Elective II Group C

Lectures - 3 Hrs per week Theory - 150 Marks

CO 614

Elective III Group D

Lectures - 3 Hrs per week Theory - 150 Marks

CO 662

Elective IV Group D

Lectures - 3 Hrs per week Theory - 150 Marks

CO 663

CO 664 Minor Project I

Practical - 2 Hrs per week Sessional - 50 Marks

The objective of this course is to develop complete Software Application- CASE Tool based on

the subjects studied during the Course

Second Year MTech (SE) III Semester

Elective V Group E

Lectures - 3 Hrs per week Theory - 150 Marks

CO 711

Elective VI Group E

Lectures - 3 Hrs per week Theory - 150 Marks

CO 712

CO 713 Self-Study Open Area Seminar -II

Practical - 2 Hrs per week Practical - 100 Marks

Objective of this course - This study should be in continuation with earlier study taken during

the Self-Study Open Area Seminar I and students must present some state-of-art innovative

techniques in the area of interest which can serve as the base-work for a workshopConference

Paper

CO 714 Minor Project -II

Practical - 4 Hrs per week Practical - 300 Marks

Objective of this course - Innovative Development of complete Software Application or a

CASE Tool based on the subjects studied amp area of interest

CO 715 Major Project Part-I

Practical - 3 Hrs per week Practical - 300 Marks

Second Year MTech (SE) IV Semester

CO 811 Major Project Part ndashII

Practical - 6Hrs per week Practical - 500 Marks

Elective I (Group C) CO 613

Software Requirements Engineering

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Software Requirements Essential of Software requirements Different Dimensions of

Software Requirements Good practices for requirements engineering improving requirements

processes and risk management

Unit 2 Software Requirements Engineering Review of various activities of Requirements

Engineering like requirements elicitation requirements analysis documentation amp review

Discussion on current trends in requirements elicitation requirements analysis models and

verifying requirements requirements specification amp requirements prioritization

Unit 3 Software Requirements Management (RM) Principles and practices of RM

Requirements attributes Change Management Process Requirements Traceability Matrix Links

in requirements chain

Unit 4 RM Tools Rational Requisite pro Caliber RM benefits of using a RM tool

Unit 5 Advances in Requirement Engineering Commercial requirements management

techniques amp tools implementing requirements management automation

Unit 6 Latest trends in requirements engineering such as aspect-oriented requirement

engineering agent-based requirement engineering

Suggested Readings

Text Book

1 Rajesh Naik and Swapna Kishore ldquoSoftware Requirements and Estimationrdquo Tata

McGraw Hill

2 Karl E Weigers ldquoSoftware Requirementsrdquo Microsoft Press 1999

3 Ellen Gottesdiener Requirements by Collaboration Workshops for Defining Needs

Addison Wesley 2002

Reference Books

1 Ian Graham Requirements Engineering and Rapid Development Addison Wesley 1998

2 Ivy Hooks and Kristin Farry Customer-Centered Products Creating successful products

through smart Requirements Management Amacom 2001

3 Dean Leffingwell and Don Widrig Managing Software Requirements A Unified

Approach Addison Wesley 1999

Software Quality amp Metrics

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Software Quality Assurance Framework What is Quality Software Quality

Assurance Components of Software Quality Assurance Software Quality Assurance Plan Steps

to develop and implement a Software Quality Assurance Plan

Unit 2 Quality Standards ISO 9000 and Comparison ISO Standards CMM CMMI PCMM 3

Sigma 6 Sigma Software Quality Models

Unit 3 Measurement basics What is Software Metrics Application Areas of Metrics

Categories of Metrics Measurement Scale Axiomatic Evaluation of Metrics on Weyukerrsquos

Properties Analyzing the Metric Data Summary statistics for preexamining data Metric Data

Distribution Outlier Analysis Correlation Analysis Exploring Analysis

Unit 4 Measuring Structure and Size Size Estimation Halstead Software Science Metrics

Information flow Metrics Measuring Quality Software Quality metrics based on Defects

Usability Metrics Testing Metrics Reliability Models

Unit 5 Object Oriented Metrics Coupling Metrics Cohesion Metrics Inheritance Metrics

Size Metrics Reuse Metrics

Unit 6 Advanced topics in software quality Empirical software engineering research in

software quality

Suggested Readings-

Text Books

1 Mordechai Ben MenachemGarry S Marliss ldquoSoftware Qualityrdquo Thomson Learning

2 Stephen H Kan ldquoMetrics and Models in Software Quality Engineeringrdquo Pearson

Education (Singapore) Pvt Ltd 2002

3 Norman E Fenton and Shari Lawrence ldquoSoftware Metricsrdquo PfleegerThomson 2003

Reference Books

1 D Galin ldquoSoftware Quality Assurance From Theory to Implementationrdquo Addison

Wesley

2 Allan C Gillies ldquoSoftware Quality Theory and Managementrdquo Thomson Learning

2003

3 Mike Konrad and Sandy Shrum CMMI Mary Beth Chrissis Pearson Education

(Singapore) Pvt Ltd 2003

Bio-Informatics

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introduction biology physics Biological hierarchy Information stages Physical

processes Information understanding

Unit 2 Methods of gene sequencing Detailed discussion on Sequences searching methods

Unit 3 Gene expression Current and prospective methods of gene profiling Data acquisition

Data standardization Linear approximations of data DNA chips Protein targeting Data

normalization Linear view

Unit 4 Statistics approaches Probabilistic notions Multivariate issues Clustering Information

handling Experimental and computational methods of structure determination for proteins and

nucleic acids

Unit 5 Ontology Annotation of genes their products and functions System biology evolution

hierarchy Medical informatics Software support Software availability Software targets Text

parsing BioPerl Statistics R-system

Unit 6 Recent Advances amp Applications of Bio-Informatics Recent trends in Computing

with bio-systems

Suggested Readings

Text Books

1 David W Mount ldquoBioinformatics Sequence and Genome Analysisrdquo Cold Spring

Harbor Laboratory Press

2 Andreas D Baxevanis ldquoBioinformatics A Practical Guide to the Analysis of Genes and

Proteinsrdquo Second Edition

3 Richard Durbin Sean R Eddy Anders Krogh Graeme Mitchison ldquoBiological Sequence

Analysis Probabilistic Models of Proteins and Nucleic Acidsrdquo Cambridge University

Press

Reference Books

1 DE Krane and ML Raymer ldquoFundamental Concepts of Bioinformaticsrdquo Pearson

Education 2003

2 B Bergeron ldquoBioinformatics Computingrdquo Prentice ndashHall 2003

Advances in Information Systems

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 E-Commerce Models Applications Creation of E-Commerce Sites Introduction to

ERP Packages

Unit 2 CRM sales Marketing amp Service Management BPOBCP Guidelines Merits-

Demerits Call Centre Brief perspective on technological concepts case studies

Unit 3 E-banking Inter-Banking Intra- Banking Transactions E-Payments Techniques for

incorporating Securities in E-banking Services

Unit 4 E-Learning Models Virtual Campus Video Conferencing Building Online

Community

Unit 5 E-Logistics Logistics amp Supplier Chain Management Warehousing Management

Transportation Distribution Management E-Governance Models Challenges Strategies amp

Tactics E-agriculture Type of Agriculture Information amp Technique dissemination Future

Trade Marketing Query Redressing Systems Information Kiosk IVR Case Study

Unit 6 Knowledge Management (KM) Components amp Type of knowledge Knowledge

building Models KM architecture KM Tools Approaches Approaches to GISGPS Nature of

Geographic Data Getting Map on Computers Standards Design Implementation amp

Deployment phases

Suggested Readings

Text Books

1 M Papazoglou and PMA Ribbers E-Business Organizational and Technical Foundations John Wiley and Sons

2 Daryl Morey Mark Maybury and Bhavani Thuraisingham Knowledge Management Classic and Contemporary Works

3 Basics of Ecommerce NIIT PHI

Reference Books

1 Erfan Turban et al Electronic CommercendashA Managerial Perspective Pearson Education

2 Andrew V Winston Electronic Commerce ndash a Mangerrsquos guideR Kalokota Pearson

Education

Modeling amp Simulation

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Basic Simulation Modeling The Nature of Simulation Systems Models and Types of

Simulation Advantages Disadvantages and Pitfalls of Simulation

Unit 2 Modeling Complex Systems Introduction List Processing in Simulation Approaches to

Storing Lists in a Computer

Unit 3 Simulation Software Comparison of Simulation Packages with Programming

Languages

Unit 4 Classification of Simulation Software General-Purpose Simulation Packages

Object-Oriented Simulation

Unit 5 Building Valid Credible and Appropriately Detailed Simulation Models

Experimental Design Sensitivity Analysis

Unit 6 Optimization Simulation of Manufacturing Systems

Suggested Readings-

Text Books

1 Frank L Severance System Modeling and Simulation - an Introduction John Wiley

2 Simulation Modeling and Analysis Third Edition Law Kelton (Mc-Graw Hill)

Elective II (Group C) CO 614

Real-Time Systems

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Real-time systems Real-time systems models Types of real-time systems Internal

structure of real-time systems Performance measures Examples of real-time systems and real-

world applications Modeling amp Designing real-time systems

Unit 2 Real-Time Process Management Task scheduling for Uniprocessor systems handling

priorities with critical section interrupts task allocation amp scheduling for multiprocessor

systems adaptive scheduling

Unit 3 Programming Environment In depth Knowledge of RTOS programming languages

tools amp techniques

Unit 4 Real-Time System Design Design techniques for Reliability Fault Tolerance amp other

application specific quality considerations

Unit 5 Trends in Real-Time System Design amp Development in fields such as Robotics

Unit 6 Introduction to research topics

Suggested Readings-

Text Books

1 AC Shaw Real-Time Systems and Software Wiley

2 JE Cooling Real-Time Software Systems International Thompson Computer Press

3 WA Halang and KM Sacha Real-Time Systems World Scientific

Reference Books

1 Real-Time Systems Design and Analysis PH Laplante IEEE Press

2 Real-Time Systems J Liu Prentice-Hall 2000

3 Real-Time Computer Control R Bennett Prentice-Hall

4 Real-Time Systems CM Krishna and KG Shin McGraw-Hill

Quantum Computing

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introduction to Quantum Computers Qubits amp their representation

Unit 2 Quantum Elements Logic Gates Circuits Architectures Algorithms

Unit 3 Quantum Information Quantum Key Distribution teleportation Single photons EPR

pairs

Unit 4 Grid Computing Data and Computational Grids Grid Architectures and its relations to

various distributed technologies Autonomic computing Cluster Setup amp its advantages

Unit 5 Performance models amp simulations Networking protocols amp IO Messaging Systems

Examples

Unit 6 Process Scheduling Load Sharing amp Balancing Distributed Shared memory parallel

IO Pervasive Computing concepts amp scenarios Hardware amp software Device Connectivity

Suggested Readings-

Text Books

1 Introduction to Quantum Computing Philip Kaye etal Oxford University Press

2 Introduction to Quantum Computers Gennady Berman World Scientific

3 Quantum Computation and Quantum Information M Nielsen and I Chuang

Cambridge University Press Cambridge 2000

Reference Books

1 Classical and Quantum ComputationA Yu Kitaev AH Shen and MN Vyalyi

American Mathematical Society Providence 2002

2 Problems amp Solutions in Quantum Computing amp Information WH Steeb and Y

HardyWorld Scientific River Edge NJ 2004

Recent Trends in Distributed Systems

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introduction Distributed System Models Inter-process Communication issues in

design of Distributed systems current amp future

Unit 2 Communications Layered Protocol Distributed Objects amp Remote Invocation Remote

Procedure Call

Unit 3 Time Logical clocks vector clocks direct dependency clocks matrix clocks

Unit 4 Resource Allocation Distributed Shared Memory Process Scheduling Load Balancing

amp Load Sharing Mutual Exclusion Election algorithms

Unit 5 Distributed File Systems Coordination amp Agreement Distributed Transaction

Consistency amp Replication Consistency Models Distribution amp Consistency Protocols

Unit 6 Advanced Topics in Distributed Systems Parallel Processing Parallel amp Distributed

Programming Case Studies in detail amp research directions

Suggested Readings-

Text Books

1 Distributed Operating Systems Concepts and Design PKSihna PHI 2007

2 Distributed Systems Principles and Paradigms 2nd Ed Andrew S Tanenbaum and

Maarten Van Steen Prentice Hall 2007 3 Distributed Operating Systems and Algorithms R Chow T Johnson Addison-

Wesley Publishing Company 1997 ISBN 0-201-49838-3

Reference Books

1 Distributed Systems Concepts and Design 4th Ed by Coulouris G Dollimore J

and Kindberg T Addison-Wesley 2006

Cluster amp Grid Computing

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Cluster Computing Introduction to concepts in Cluster based distributed computing

Hardware technologies for cluster computing and software for cluster computing and different

Software Architecture for Cluster Computing

Unit 2 Programming Programming Models and Paradigms features and performance of

standard MPI variants Derived data types communicators

Unit 3 Resource management and scheduling Managing cluster resources single system

images system level middleware distributed task scheduling monitoring and administering

system resources Parallel IO and Parallel Virtual File System Scheduling Condor Maui

Scheduler Portable Batch System (PBS)

Unit 4 Grid Computing Grids and Grid Technologies Programming models and

Parallelization Techniques Grid Security Infrastructure Setting up Grid deployment of Grid

software and tools and application execution

Unit 5 Standard application development tools and paradigms Performance evaluation

tools HINT netperf netpipe ttcp Iperfmessage

Unit 6 Data Management Application Case Study Molecular Modeling for Drug Design and

Brain Activity Analysis Resource management and scheduling

Suggested Readings-

Text Books

1 William Gropp Ewing Lusk Thomas Sterling Beowulf Cluster Computing with

Linux 2nd edition MIT Press

2 Bart Jacob Michael Brown Introduction to grid computing

3 Gregory F Pfister In Search of Clusters The ongoing battle in lowly parallel

computing Second Edition Prentice Hall Publishing Company 1998

2

COURSE CURRICULUM amp SCHEME OF EXAMINATION

for

MTech (Nano-Science amp Technology) 2017-2018

Semester I Examination November 2017

Semester II Examination May 2018

Semester III Examination November 2018

Semester IV Examination May 2019

Scheme of Examination for MTech Nano-Science and Technology (Offered by Applied Physics Department)

Sem Group Details No of papers

Marks Internal (Each Paper)

Marks External

(Each Paper)

Total Marks (Each Paper)

Semester Total

I A Course work of 3 Core Theory papers 3 50 100 150 1000

(20 Credits)

1 Laboratory 1 30 70 100 B Course work of 2 Core Theory papers 2 50 100 150

1 Laboratory 1 30 70 100 Self study Open area Seminar-I - 50 - 50

II C Course work of 1 Core amp 2 Elective Theory Papers

3 50 100 150 1000

(20 Credits)

1 Laboratory 1 30 70 100 D Course work of 2 Elective Theory papers 2 50 100 150

1 Laboratory 1 30 70 100 Minor project-I - 50 - 50

III E Course work of 2 Elective Theory papers 2 50 100 150 1000

(20 Credits) Self study Open area Seminar-II - 50 50 100

Minor Project-II - 150 150 300 Major Project Part-I - 150 150 300

IV F Major Project Part-II - 500 500 1000 1000

(20 Credits) TOTAL 4000

(80 Credits)

3

COURSE STRUCTURE FOR MTech FIRST SEMESTER (Nano-science amp Technology)

SNo Course No Subject LTP Evaluation Internal External

Total Marks

Credit

1 AP-501 Computational Physics and Programming

300 50 100 150 3

2 AP-502 Chemistry for Nano -science and Technology

300 50 100 150 3

3 AP-503 Physics for Nano-science and Technology

300 50 100 150 3

4 AP-504 Engineering of Materials Laboratory-I 002 30 70 100 2

5 AP-551 Characterization of Materials 300 50 100 150 3

6 AP-552 Fundamental of Nano-science and technology

300 50 100 150 3

7 AP-553 Engineering Materials Laboratory-II 002 30 70 100 2

8 AP-554 Self study Open Area Seminar I 001 50 - 50 1

TOTAL 20 hrs 1000 20

COURSE STRUCTURE FOR MTech SECOND SEMESTER (Nano-science amp Technology)

SNo Course No Subject LTP Evaluation Internal External

Total Marks

Credit

1 AP-601 Physics of Low Dimensional Systems 300 50 100 150 3

2 AP-6021 Materials Science at Nanoscale (Elective-I)

300 50 100 150 3

3 AP-6031 Processing amp Fabrication of Nanostructures (Elective-II)

300 50 100 150 3

4 AP-6511 Nano electronics amp Nano photonics (Elective-III)

300 50 100 150 3

5 AP-6521 Semiconductors Nanostructures amp Devices (Elective-IV)

300 50 100 150 3

6 AP-604 Processing amp Fabrication of Nanostructure Lab

002 30 70 100 2

6 AP-653 Characterization of Materials Science lab

002 30 70 100 2

7 AP-654 Minor Project I 001 50 - 50 1

TOTAL 20 hrs 1000 20

4

COURSE STRUCTURE FOR MTech THIRD SEMESTER (Nano-Science amp Technology)

SNo Course No Subject LTP Evaluation

Internal External

Total

Marks

Credit

1 AP-7011 Nano Electromechanical Materials amp

Devices (Elective-V)

300 50 100

150 3

2 AP-7012 Functional material and device

(Elective-V)

3 AP-7021 Nano Biotechnology (Elective-VI) 300 50 100 150 3

4 AP-703 Self study Open Area Seminar II 002 - 100 100 2

5 AP-704 Minor Project II 006 150 150 300 6

6 AP-705 Major Project I 006 150 150 300 6

TOTAL 20 hrs 1000 20

COURSE STRUCTURE FOR MTech FOURTH SEMESTER (Nano-Science amp Technology)

SNo Course No Subject LTP Evaluation

Internal External

Total

Marks

Credit

1 AP-801 Major Project II - 500 500 1000 20

TOTAL 1000 20

5

SYLLABUS MTech (NanoScience amp Technology)

AP-501 Computational Physics and Programming (3-0-0)

Unit I

A review of the numerical techniques (Interpolations differentiations integrations nonlinear

equations the bisection methods Newtonrsquos method root findings Differential equations Eulerrsquos

method the Runge-Kutta method Matrices-inverting finding eigen values and eigen functions

Bessel functions Hermite Legendre and Lagurre polynomials etc

Unit II

Simple problems based on section-I using Matlab Mathematica (mechanics optics and quantum

mechanics ) Atomistix and related softwares Introduction to Lab view software

Unit III

C++ Programming Introduction to Object oriented Paradigm Basic concept of Object Oriented

Programming (OOP) Benefits of OOP Applications of OOP Classes and Objects- specifying a

class memory allocations for objects static daa members and member functions array of objects

Objects as function arguments friendly Functions returning objects constructors and destructors

Unit IV

Inheritance and Polymorphisms Inheritance types of inheritance Derivation-Public private and

protected polymorphism types of polymorphism- compile time and runtime function overloading

operator overloading virtual functions

References

1 Handbook of Theoretical and Computational Nanotechnology Eds Michael Rieth and Wolfram

Schommers 2006

2 Introductory Computational Physics Kelvin and Godunov (Cambridge)

3 Computational physics RC Verma KC Sharmaamp PK Ahluwalia

4 Introduction to Computer simulations Gould Tobochnik etal (Addition Wesely 2006)

5 Visual basic and C++ Schuam Series

6 Mat labs Programming by Rudrapratap Singh

7 Mathematical Physics Harper

8 Applied mathematics for engineers amp Physicist Pipes and Harvil

9 Numerical Recepies in C The art of scientific Computing WH Press

10 Computer Programming Language Addition Wesely

11 Object oriented Programming in turbo C++ Robert Lafore

6

AP-502 Chemistry for Nano Science amp Technology (3-0-0)

Unit I

Surface adsorption Definition Significance and Applications of it Freudlich and Langmiur

Adsorption Isotherm Gibbrsquos Isotherm Their fundamental approach to Nanomaterials

Unit II

Colloidal chemistry Colloidal properties origin of charge on colloidal properties Determination of

colloidal particle size Synthesis of Nano materialsNano systems employing chemical

precipitation coprecipitation sol-gel synthesis microemulsion thermolysis Electrochemical and

photochemical methods

Unit III

Nano polymersNanocomposites Synthesis Characterization Properties and applications of Nano

polymersNanocomposites ie Polymers metal oxide glass and ceramic based nano composites and

their use in catalysis

Unit IV

Metal and Alloy Nanoparticles Preparation and Stabalization of MetalAlloy nanoparticles particle

size determination particle size distribution their conducting semiconducting and catalytic

properties Separation and purification of Nano particles by Membrane Technology Ion Exchange

Membranes Electrodialysis Reverse Osmosis Ultrafiltration Microfiltration and Nanofiltration

Techniques

References

1 Nanocomposites Science and Technology by PM Ajayan LS Schodler Wiley New York

2 Chemistry of Nanomaterials Synthesis properties and applications by C N R Rao Wiley New York

3 Nanochemistry A chemical approach to nanomaterials- Royal Society of Chemistry Cambridge UK

2005

4 Active Metals preparation Characterization and Application by A Frustner Ed VCH New York 1996

5 Membrane Handbook WSWinston Ho amp Kamlesh K Sirkar Chapman hall (1992)

6 Colloidal Dispersion ndash Russel WB Saville DA Cambridge University Press 1989

7 Surfactants and Polymers In Aqueous by K Holmberg B jonsson B Kromberg Wiley England 2004

7

AP-503 Physics for Nano Science and Technology (3-0-0)

Unit I

Review of fundamentals of Quantum mechanics Schroumldinger equation tunneling density of states

free electron theory of metals The angular momentum problem The spin half problem and

properties of Pauli spin matrices

Unit II

Approximate methods Time independent and time dependent perturbation Theory for non-

degenerate and degenerate energy levels the variational Method WKB approximation adiabatic

approximation sudden approximation

Unit III

Statistical Mechanics Microstates and entropy and its statistical definition Entropy of mixing

Gibbrsquos free energy Gibbrsquos paradox phase space density ergodic hypothesis Liouvillersquos theorem

The microcanonical- canonical- and grand canonical ensemble and their connections Fluctuations

Classical Statistical systems Boltzman statistics and quantum statistical systems Fermi-Dirac and

Bose-Einstein Statistics and their applications (an overview)

Unit IV

Crystal structure crystallographic planes Miller indices Braggrsquos law X-ray Diffraction particle

size determination Confinement and transport in Nanostructures Current reservoirs and electron

channels conductance formula for nanostructures quantized conductance Local density of states

Ballistic transport Coulomb blockade Diffusive transport Fock space Dielectric properties

Polarization ferroelectric behaviour Optical Properties Photoconductivity Optical absorption and

transmission Photoluminescence Fluorescence Phosphorescence Electroluminescence

References

1 Quantum Physics- A Ghatak

2 Quantum Physics of atoms Molecules Solids Nuclei and particles 2nd edition by Eisberg Robert

Resnik Robert

3 Principles of Quantum Mechanics 2nd ed ndash R Shankar

4 Statistical Physics by K Huang

5 Statistical Mechanics- Landau amp Lifshitz

6 Statistical Mechanics- Sonntag

7 Introduction to Solid State Physics- C Kittel Solid State Physics- AJ Dekker

8 The Physics and Chemistry of Solids- Stephen Elliott amp SR Elliot

9 Scanning Probe Microscopy Analytical Methods(NanoScience and Technology)-Roland Wiesendanger

10 Advance X-ray Techniques in Research and Industries ndash AKSingh(editor)

11 Basic Solid State Chemistry ndash Anthony RWest

8

AP-551 Characterization of Material (3-0-0)

UNIT I

X-ray Diffraction Braggrsquos law Application in crystallography Diffractogram Paricle size

determination using XRD

UNIT II

Probe techniques Atomic force Microscopy (AFM) scanning electron microscopy (SEM)

Scanning tunneling microscopy (STM) Transmission Electron Microscopy (TEM) High

Resolution Transmission Electron Microscopy (HRTEM)

UNIT III

Infrared Spectroscopy Raman Spectroscopy Electronic spectroscopy for atoms and molecules

Spin Resonance Spectroscopy Nuclear Magnetic Resonance spectroscopy (NMR)

UNIT IV

Deep level transient spectroscopy (DLTS) Kelvin-probe measurements Nanoscale current-voltage

(I-V) investigations Capacitance-Voltage (C-V) Relationships

References

1 Nanostructures amp Nano Materials Ghuzang Cao

2 Handbook of Nanophase amp Nanomaterials (vol IampII) Zhong Lin Wang

3 Fabrication of fine pitch by holography electron beam lithography and nano-imprint lithography

(proceeding papers) Author(s) Darren Goodchild Simon Wingar Nak Kim

4 Microfabrication and Nanomanufacturing- Mark James Jackson

5 Processing amp properties of structural nanomaterials- LeonLShaw(editor)

6 Fundamentals of molecular spectroscopy C N Banwell Tata McGraw

9

AP-552 Fundamentals of Nano-Science amp Technology (3-0-0)

UNIT I

Introduction and Classification What is nanotechnology The Canvas of Nano Classification of

nanostructures Nanoscale architectures Effects of nanometer length scale Changes to the system

total energy changes to the system structure Nanoscale dimensions and its affects properties

UNIT II

Investigating and manipulating materials at nanoscale Introduction Electron microscopies

Scanning probe microscopies Other kinds of microscopies X-Ray Diffraction Associated

techniques

UNIT III

Fabrication Methods Top Down Processes Bottom Up Processes of Silicon nanowire ZnO

nanowire Carbon nanotubegrapheme Ordering of nanosystems Preparation Safety and Storage

issues Fa

UNIT IV

Society and Nano Societal implications of nanotechnology Introduction From first Industrial

Revolution to the Nano Revolution Issues and outlook Harnessing Nanotechnology for social and

economic development

References

1 Introduction to Nanotechnology Charles PPoole Jr and Frank J Owens

2 Nanotechnology Principles and Practices Sulabha K kulkarni

3 Nanoscale Science and Technology Robert W Kelshall Ian W Hamley and mark Geoghegan

4 NanoThe Essentials ndashUnderstanding Nanoscience and Nanotechnology ndashT Pradeep

5 Handbook of Nanotechnology Bharat Bhusan

10

AP-601 Physics of Low Dimensional Systems (3-0-0)

UNIT I

Maxwell-Boltzmannrsquos statistics Fermi-Dirac statistics and fermions Paulirsquos exclusion principle

Bose Einstein statistics Bosons Bose condensation

UNIT I

Molecular structure Born oppenheimer approximation electronic structure ionic and covalent

bonding H2 H2+ vibrational and rotational structure

UNIT III

Molecular spetra microwave infrared and optical spectra of molecules selection rules suitable

examples

UNIT IV

Transport properties parallel and perpendicular transport quantization of conductance density of

states coulomb blockade kondo effect Hall quantum Hall and fractional Hall effects Other

relevant topics

References

1 Quantum Mechanics by L I Schiff

2 Quantum Mechanics by J L Powell and Crasmann

3 Introduction to Quantum Mechanics by Pauling amp Wilson

4 Quantum Mechanics by A K Ghatak amp S Loknathan

5 The Physics of low-dimensional semiconductors An introduction by J H Davies

6 Concepts of Modern Physics by Arthur Beiser

7 Physics of Molecules by Wolf Gang Demtroder

8 Handbook of Molecular Physics amp Quantum Chemistry by Stephen Wilson

9 Quantum Heterostructures by Maiteir and others

11

AP-6021 Materials Science at Nanoscale (3-0-0)

UNIT I

Single crystalline polycrystalline and amorphous structures crystal structure classification of

crystals imperfection in solids grain boundaries and its effect on mechanical properties Phase

transitions in nanosystems-comparison to large systems

UNIT II

Carbon molecules nature of carbon bonds new carbon structures small carbon clusters C60-

crystal structure larger and smaller fullerenes Buckyballs Carbon Nanotubes-fabrication

structure electrical vibrational and mechanical properties

UNIT III

Applications in field emission shielding computers fuel cells sensors catalysis mechanical

reinforcement

Bulk nanostructured materials synthesis mechanical and electrical properties metal nanocluster

composite glasses porous silicon natural nanocrystals nanoparticles in zeolites crystals of metal

naoparticles nanoparticle lattices in suspensions photonic crystals nanocopmposites

nanoceramics ceramic matrix composites

UNIT IV

Nanostructured ferromagnetism effect of nanostructuring nanomagnets nano carbon ferromagnets

giant and colossal magnetoresistance ferrofluids Nanocmposites of dielectric piezoelectric and

ferroelectric materials Polarization types frequency dependence other relevant current topics

References

1 Materials Science amp Engineering An introduction by W D Callister

2 Introduction to Solid State Physics by C Kittel

3 Solid State Physics by A J Dekker

4 Solid State Physics by Aschroft amp Mermin

5 Nanocomposite Science and Technology by Ajayan Schadler and Braun

6 Principles of Nanotechnology by G Ali Mansoori

7 Nanomaterials Nano-tech amp Design by Michael F Ashby

12

AP-6031 Processing amp Fabrication of Nanostructures (3-0-0)

UNIT I

Fundamental concepts of Bottom-up and top down approaches self assembly and self organization

formation of nanostructure by mechanical milling (ball milling)

UNIT II

Synthesis of carbon nanotubes growth mechanism arc discharge laser ablation sputtering and

growth from solutions and melts

UNIT III

Chemical vapor deposition plasma enhanced CVD thermal CVD vapor phase growth laser

assisted thermal CVD CoMoCat process High pressure CO dispropornation process flame

synthesis pulsed laser deposition (PLD)

UNIT IV

Fabrication of nanoparticles synthesis of colloidal particles synthesis of nanogold particles

synthesis of nanocomposites and nanostructures fabrication of quantum dots nanowires nanorods

nanointermetallics controlled colloidal synthesis Synthesis of polymer supported clusters and

polymeric nanofibers

Nanolithography electron beam and focused ion beam lithographies other relevant current topics

References

1 Nanotechnology by Gregory Timp

2 Introduction to Nanoscale Science amp Technology by M Di Ventra et al

3 Nanophotonics by Paras N Prasad

4 Microlithography Sciences amp Technology ndash Sheats J R and Amith B W (Marcel Dekker Inc New York)

5 Nanolithography A borderland between STM EB IB and X-ray lithographies- M Gentili et al

(Springer)

13

AP-6511 Nano Electronics amp Nano photonic (3-0-0)

UNIT I

Photons and electrons- similarities and differences confinement of photons and electrons

Nanoscale optical interactions-axial and lateral nanoscopic localization quantum confinement

effects cooperative transitions and emission

UNIT II

Quantum well double quantum wells wires dots rings size effects manifestation of quantum

confinement-optical properties conduction electrons and dimensionality potential wells resonant

tunneling and ballistic transport single-electron tunneling infrared detectors quantum dot lasers

UNIT III

Photonic crystals-basic concepts features of photonic crystals photonic crystal optical circuitry

non-linear photonic crystals photonic crystal fibers optical communication and sensors

UNIT IV

Basics of nanoelectronics and molecular electronics break junction nanowires nanocircuits single

molecule magnet molecular conductance molecular logic gate MEMS other relevant topics

Fundamentals of Spintronics spin polarized transport Kondo effect Kubo effect spin relaxation

and injection Spintronics memory devices and applications

References

1 Nanophotonics by Paras N Prasad

2 Introduction to Nanoscale Science amp Technology by M Di Ventra et al

3 Handbook of Photonics by Mool Chand Gupta amp John Ballato

4 Optical properties of photonic crystals by K Sakoda

5 Detection of optical and infrared radiation by Kingston amp Mac Adam

6 Introduction to Nanotechnology by C P Poole Jr and Franks J Owens

7 Spintronics fundamentals and applications by I Zutic and SD Sarma

8 Introduction to spintronics by Supriyo Bandopadhayay

9 Spin electronics by David D Awschalom

10 Quantum Electronics by A Yariv

14

AP-6521 Semiconductors Nanostructures amp Devices (3-0-0)

UNIT I

Basics of semiconductors microelectronic devices and technology silicon technology processing

of III-V semiconductors semiconductor nanoparticles synthesis cluster compounds quantum dots

using MBE CVD and MOCVD

UNIT II

Semiconducting nanoparticles size dependent physical properties band-gap variations-quantum

confinement Fundamentals of carrier transport in quantum structures electrical transport properties

in semiconductors nanostructures temperature effects resonating tunneling diodes structure and

operation of MOS

UNIT III

Small dimension effects Nanoscale MOSFET transistors LED and solar cells Doping nano

particles

Semiconductor nanowires fabrication and integration quantum conductance effects in

semiconductors porous silicon nanobelts nanoribbons nanosprings

UNIT IV

Single electron tunneling superconducting single electron transistor implementation of single

electron transistors applications of single electron transistors other relevant current topics

References

1 Introduction to Nanoscale Science amp Technology by M Di Ventra et al

2 Nanotechnology by Gregory Timp

3 Nanophotonics by Paras N Prasad

4 Introduction to Nanotechnology by C P Poole Jr and Franks J Owens

5 Encyclopedia of Nanotechnology by Hari Singh Nalwa

6 Handbook of Semiconductor Nanostructures amp Nanodevices Volumes-1-5 A A Balandin and K L Wang

7 Nanostructures and Nanomaterials ndash Synthesis Properties amp Applications by Cao amp Guozhong

15

AP-7011 Nano Electromechanical Materials amp Devices (Elective-V (3-0-0)

UNIT I

Introduction of carbon materials Diamond nanodiamond fullerene graphene carbon fiber and

amorphous carbon Synthesis route CVD for synthesis of nanodinamond carbon nanotube and

graphene and other methods of preparation of CNT and graphene

UNIT II

Structure and properties of carbon nanotubes and graphene Electrical Optical Mechanical

Vibrational properties etc

UNIT III

Applications of carbon nanotubes and graphene Biosensors FET Field emission Fuel Cells

Display devices

UNIT IV

Functionalization and purification method for carbon nanotubes Oxidative Purification Defect

Functionalization ndashTransformation and Modification of Carboxylic Functionalization like

Amidation Thiolation Halogenations Hydrogenation Addition of Radicals Addition of

Nucleophilic Carbenes Sidewall Functionlaization through Electrophili Addition Cycloadditions

Carbenes Addition Addition of Nitrenes Noncovalent Exohedral Functionalization Endohedral

Functionalization

References

1 Nanoscale materials -Liz Marzan and Kamat

2 Physical properties of Carbon Nanotube-R Satio

3 Applied Physics Of Carbon Nanotubes Fundamentals Of Theory Optics And Transport Devices - S

Subramony amp SV Rotkins

4 Carbon Nanotubes Properties and Applications- Michael J OConnell

5 CARBON NANOTECHNOLOGY- Liming Dai

6 Nanotubes and Nanowires- CNR Rao and A Govindaraj RCS Publishing

16

AP-7021 Nanobiotechnology (3-0-0)

UNIT I

Biological Methods of Synthesis Use of bacteria fungi Actinomycetes for nanoparticle synthesis

Magnetotactic bacteria for natural spynthesis of magnetic nanoparticles Mechanism of formation

Viruses as components for the formation of nanostructured materials Synthesis process and

application Role of plants in nanoparticle synthesis

UNIT II

Microorganisms for synthesis of nanomaterials and for toxicity detection Natural and artificial

synthesis of nanoparticles in microorganisms Use of microorganisms for nanostructure formation

Testing of environmental toxic effect of nanoparticles using microorganisms

UNIT III

Nanocomposite biomaterials teeth and bone substitution Natural nanocomposite systems as spider

silk bones shells organic-inorganic nanocomposite formation through self-assembly Biomimetic

synthesis of nanocomposite material Use of synthetic nanocomposites for bone teeth replacement

UNIT IV

Nanobio Systems Nanoparticle-biomaterial hybrid systems for bioelectronic devices Bioelectronic

systems based on nanoparticle-enzyme hybrids nanoparticle based bioelectronic biorecognition

events Biomaterial nanocircuitry Protein based nanocircuitry Neurons for network formation

DNA nanostructures for mechanics and computing and DNA based computation DNA based

nanomechanical devices Biosensor and Biochips

References

1 Bionanotechnology Lessons from Nature by David S Goodsell

2 Nanomedicine Vol IIA Biocompatibility by Robert A Freitas

3 Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology - Hari Singh

Nalwa

4 Nanobiotechnology ed CMNiemeyer CA Mirkin

5 Nanocomposite Science amp Technology Ajayan Schadler amp Braun

6 BioMEMS (Microsystems) - Gerald A Urban

7 Introduction to Nanoscale Science and Technology (Nanostructure Science and Technology) ndash

Massimiliano Di Ventra

8 Nanosystems Molecular Machinery Manufacturing and Computation - K Eric Drexler

9 Springer Handbook of Nanotechnology - Bharat Bhushan

10 Nanobiotechnology ed CMNiemeyer CA Mirkin

12 Nanomedicine Vol I Basic Capabilities

13 Nanomedicine Vol IIA Biocompatibility - Robert A Freitas

17

Self-Study Open Area Seminar-I ampII

Compulsory seminar by each candidate on the emerging topics related to nanotechnology

Minor (I ampII) or Major Project

A minor project related to emerging areas in the nanotechnology is to be completed Emphasis will

be given of area related to synthesis characterization and device fabrication Faculty member will

help for selecting area of major projects

Scheme of Examination and Syllabus

MTech in Industrial Biotechnology

Department of Biotechnology Delhi Technological University

Bawana Road New Delhi -110042

MTech in Industrial Biotechnology Biotechnology Industry Organization (BIO) USA has mentioned three major waves in the field of

biotechnology The first wave Green Biotechnology refers to agricultural biotechnology The

second wave Red Biotechnology refers to pharmaceutical and medical biotechnology while the third

wave White Biotechnology refers to industrial biotechnology Industrial biotechnology is mainly

based on biocatalysis (the use of enzymes and cells to catalyse chemical reactions) and fermentation

technology (directed use of micro-organisms) in combination with recent breakthroughs in the

forefront of molecular genetics and metabolic engineering It includes manufacturing of antibiotics

(cephalosporins streptomycin penicillin) food (yoghurt cheese single cell protein mushroom

probiotics) renewable energy (bioethanol biodiesel biohydrogen) health care (growth hormone

antibodies) biopolymers (polyhydroxy butyrate polylactic acid) enzymes (protease lipase amylase

cellulase pectinase xylanase) in various industries (pulp and paper detergent textile food

processing industry) Industrial biotechnology also involved in bioremediation microbial

degradation of pollutants (hydrocarbons polychlorinated biphenyl polyaromatic hydrocarbons)

Biological waste water treatment is undoubtedly one of the most important biotechnological

processes which have been used to treat municipal waste and industrial waste water The proposed

syllabus has been developed to address the need of well trained industrial biotechnologist cutting

edge RampD for this field The trained manpower will be well versed in techniques of protein science

bio-catalysis engineering biosynthesis microbial manufacturing engineering biological systems and

bio-process engineering Moreover they can easily implement these hands on training in industry to

increase the yield more accurately

Delhi Technological University Delhi

Department of Biotechnology

Scheme of Examination

MTech in Industrial Biotechnology

First semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-521 Bioenergy 3 1 0 50 100 150 3

BT-522 Food Engineering

amp Biotechnology

3 1 0 50 100 150 3

BT-523 Enzyme

Engineering amp

technology

3 1 0 50 100 150 3

BT-571 Industrial Plant

Biotechnology

3 1 0 50 100 150 3

BT-572 Bioinstrumentation 3 1 0 50 100 150 3

BT-573 Food engineering

and Biotechnology

Lab

0 0 2 30 70 100 2

BT-524 Bioinstrumentation

Lab

0 0 2 30 70 100 2

BT-574 Self Study open

area seminar-I

0 0 1 50 - 50 1

TOTAL 360 640 1000 20

Second semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-621 Biopharmaceuticals 3 1 0 50 100 150 3

BT-6221 Bioprocess

Engineering

3 1 0 50 100 150 3

BT-6231 Biosensor 3 1 0 50 100 150 3

BT-6711 Nanobiotechnology 3 1 0 50 100 150 3

BT-6721 Environmental

Biotechnology

3 1 0 50 100 150 3

BT-673 Environmental

Biotechnology Lab

0 0 2 30 70 100 2

BT-624 Bioprocess

Engineering Lab

0 0 2 30 70 100 2

BT-674 Minor Project-I 0 0 1 50 - 50 1

TOTAL 360 640 1000 20

Third semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-721 Professional

Elective I

3 1 0 50 100 150 3

BT-722 Professional

Elective II

3 1 0 50 100 150 3

BT-723 Self Study open

area seminar-II

0 0 1 100 100 2

BT-724 Minor Project-II 300 300 6

BT-725 Major Project-I 300 300 6

TOTAL 200 800 1000 20

Fourth semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-821 Major Project-II 400 600 1000 20

TOTAL 1000 20

BT- 721 ELECTIVE SUBJECTS- I

BT-7211 Bioseparation Technology

BT-7212 Industrial waste water treatment

BT-7213 Biopolymer Technology

BT-7214 Bioprocess Plant Designing

BT-7215 Transport Phenomenon

BT-7216 Biochemical Thermodynamics

BT-722 ELECTIVE SUBJECTS- II

BT-7221 Bioethics Biosafety and IPR

BT-7222 Quality Management

BT-7223 Protein Engineering

BT-722 4 Metabolic Engineering

BT-7225 Design and Development of Biological Treatment process

BT-7226 Bioinformatics

SEMESTER I

BT- 521 Bioenergy

Unit-I

Introduction

Global energy scenario Indian energy scenario types of energy sources description of Biofuels

various Biofuels Bioenergy from biomass Biofuel Production Alternative Biochemical Pathways for

Organo-heterotrophic Lithotrophic and Phototrophic Metabolism Importance of biofuel feed stocks

Cellulose starch sugar Lignocellulosic Agro and Industrial by-products

Unit-II

Production of Bio-ethanol

Process Technology for Bioethanol production using Sugar Starch and Lignocellulosic Selection of

micro-organisms and raw materials Unit Operations in Alcohol production Continuous

fermentation Distillery quality control Alcohol distillation

Unit-III

Production of Biodiesel

Chemical Thermodynamic and Reaction Kinetic Aspects of Biodiesel Production Lipids as a source

of biodiesel Methods of Biodiesel Production ndash General procedure and large scale production

Quality Control Aspects Biodiesel production from microalgae and future prospects

Unit-IV

Production of Biohydrogen

Biohydrogen production by anaerobic bacteria and photosynthetic algae Enzymes involved in

biohydrogen Production Biochemical Pathway Batch Fermentation Factors affecting biohydrogen

production Carbon sources Process and Culture Parameters Detection and Quantification of

biohydrogen

Unit-V

Microbial Fuel Cells

Introduction and biochemical basis History of microbial fuel cell development Microbes used in

microbial fuel cells Design of microbial fuel cells MFC components Two and Single MFC systems

Stacked microbial fuel cell Performances of microbial fuel cells Ideal performance Actual MFC

performance Effects of operating conditions pH buffer and electrolyte Proton exchange system

Operating conditions in the anodic chamber Operating conditions in the cathodic chamber

Applications Electricity generation Biohydrogen Wastewater treatment Biosensor MFCs in the

future

Unit-VI

Case studies

Text books

1 Caye M Drapcho NP Nhuan and T H Walker Biofuels Engineering Process Technology Mc

Graw Hill Publishers New York 2008

2 Jonathan RM Biofuels ndash Methods and Protocols (Methods in Molecular Biology Series) Humana

Press New York 2009

3 Lisbeth Olsson (Ed) Biofuels (Advances in Biochemical EngineeringBiotechnology Series

Springer-Verlag Publishers Berlin 2007

BT- 522 Food Engineering and Biotechnology

Unit- I

Food chemistry

Food chemistry-definition and importance Composition of foods and function of water

carbohydrates proteins amino acids lipids vitamins and shelf life of food Bioavailability and

stability of nutrients Nutritive value of foods Food as a source of energy Food Health and diseases

Unit ndash II

Food Microbiology

History and significance of microorganisms in foods Biotechnological improvements catabolic

repression Microbial growth pattern Biochemical changes caused by micro-organisms deterioration

of various types of food product Food poisoning and microbial toxins standards for different foods

Food borne intcericants and mycotoxius

Unit ndashIII

Fermentation products

Dairy products Production of starter cultures Cheese - principles of cheese making Cheddar

Cheese Swiss Cheese Surface ripened Cheeses Mold ripened Cheeses General principles of

manufacture of Kefir Fermented foods Soy sauce Miso Sufu Natto Idli fermented fish products

Fermented vegetables Sauer Krant pickles Olives Fermented sausages Distilled beverages

Alcohol wine brandy and beer Food additives organic acid (acetic acid lactic acid and citric acid)

amino acids (glutamic acid lysine threonine arginine and histidine) food flavourants and pigments

Unit ndashIV

Food Preservation and storage

General principles underlying spoilage and chemical changes of food caused by microorganisms

(Staphylococcal Salmonellosis Ecoli) food spoiling enzymes Botulism toxin production and

deterioration of foods Principles of food preservation by physical methods (irradiation drying heat

processing chilling and freezing high pressure and modification of atmosphere) by chemical

methods and biological methods Storage Stability Food Preservation with Low Temperatures Food

Preservation with High Temperatures Preservation of Foods by Drying Indicator and Food-borne

Pathogens

Unit V

Food process technology

Packaging and canning of foods ndash preparation for packaging thermal processing of foods

Microwave heating thermal inactivation of microorganisms thermal process evaluations freezing

and thawing of foods Food process operations Evaporation single and multi effect evaporation

dehydration psychomatric charts drying-tunnel tray spray drum freeze distillation food

processing aid through biotechnology Food sanitation Good manufacturing practices ndash Hazard

analysis Critical control points Personnel hygiene

Unit ndashVI

Food Processing and Quality assurance

Basic principles unit operations and equipment involved in the commercially important food

processing methods and unit operations materials and containers used in food packaging Objectives

importance and functions of quality control Methods of quality assessment of food materials-fruits

vegetables cereals dairy products meat and poultry Food regulations grades and standards

Concept of Codex AlmentariousHACCPUSFDAISO 9000 series etc Food laws and standards

Text Books

1 Frazier WS and Weshoff DC Food Microbiology 4th Edn McGraw Hill Book Co New

York 1998

2 Mann amp Trusswell Essentials of human nutrition 3rd edition oxford university press 2007

3 Prescott and Dunns Gerald Reed Industrial Microbiology 4th Edition AVI Publishing Company

Inc Conneticut 1983

4 BSivashankar ndash Food processing and preservation Prentice ndash Hall of India PvtLtdNew Delhi

2002

BT- 523 Enzyme Engineering and Technology

Unit-I

Introduction to enzymes

Introduction nomenclature and classification of enzyme Mechanism and catalysis concept of active

site and energetics of enzyme substrate complex formation specificity of enzyme action principles

of catalysis ndash collision theory transition state theory role of entropy in catalysis Biocatalysis in

organic liquids Enzymatic catalysis in biphasic system Ribozyme Abzyme (catalytic antibodies)

Biosynthesis and regulation of enzyme in microorganism

Unit-II

Enzyme Kinetics

Kinetics of substrate and multisubstrate reactions King-Altmanrsquos method Analysis of kinetic data

Inhibition - substrate product and inhibitors Active and legend binding sites Allosteric regulation of

enzymes Monod changeux wyman model deactivation kinetics Molecular folding and defolding of

enzymes

Unit - III

Enzyme immobilization

Methods of immobilization External and internal diffusional mass transfer limitation Effectiveness

factor and modulus electrostatic and stearic effects in immobilized enzyme systems

Unit-IV

Enzyme Reactor

Reactors for Batch continuous enzymatic processing choice of reactor type idealized enzyme

reactor systems Mass transfer in enzyme reactors Steady state analysis of mass transfer and

biochemical reaction in enzyme reactors

Unit ndashV

Purification and Characterization of enzymes from natural source

Production and purification of crude enzyme extracts from plant animal and microbial sources

methods of characterization of enzymes

Unit-VI

Application of enzymes

Application of enzymes in different industries (Pulp and Paper industry Detergent industry Textile

industry Food processing industry) Medical and analytical application of enzyme Biosensor

Text books

1 Enzymes A Practical Introduction to Structure Mechanism and Data Analysis by RA Copeland

Publisher John Wiley and Sons Inc

2 Enzymes by Palmer (2001) Horwood Publishing Series

3 Introduction to Biocatalysis using Enzymes and Microorganisms by SM Roberts NJ Turner and

A J Willetts Publisher Cambridge University Press

4 Fundamentals of Enzymology by Price and Stevens (2002) Publisher Oxford University Press

5 Enzyme Technology by Helmut Uhling (1998) Publisher John Wiley

6 Introduction to Proteins Structure by Branden and Tooze (1998) Publisher Garland Publishing

7 Enzyme Kinetics Behavior and Analysis of Rapid Equilibrium and Steady - State Enzyme

Systems by IH Segel Publisher Wiley-Interscience

BT-571 Industrial Plant Biotechnology

Unit-I

Plant genome organization

Organization and features of mitochondrial nuclear and choloroplast genome ndash Structural features of

gene families in plants

Unit-II

Plant cell cultivation

Callus cultures cell cultures and protoplast cultures Micropropagation Organogenesis and somatic

embryogenesis Cell suspension culture Ovule culture Anther culture Production of haploids

Protoplast isolation and fusion Selection systems for somatic hybridscybrids Somaclonal variation

Preservation of germplasm Formation of Secondary Metabolites in Tissue Culture Production of

pharmaceuticals by tissue culture pigments perfumes flavors insecticides flavonoids

Biotransformation using plant cell cultures Bioreactor system and models for mass cultivation of

plant cells hairy root culture Quality assurance and quality control

Unit-III

Transgenic plant and application

Transgenesis in plants Gene transfer in plants ndash Gene transfer through vectors - Biology of vectors

used - Ti and Ri plasmids binary vectors viral vectors cloning strategy and method of gene transfer

Vectorless gene transfer ndash electroporation and gene gun method DNA bar coding Application of

transgenic plants Virus resistance coat protein mediated nucleocapsid gene Nematode resistance

Abiotic stress Drought cold and salt Post-harvest losses long shelf life of fruits and flowers use of

ACC synthase polygalacturanase ACC oxidase male sterile lines bar and barnase systems

carbohydrate composition and storage ADP glucose pyrophosphatase RNAi and Reverse genetics

Unit- IV

Natural Resource Management

Different approaches of Biodiversity Conservation Biotechnological Characterization and strategies

for the conservation of different populations of endangered plants Molecular markers and genetic

diversity screening

Unit-V

Plant metabolism Metabolomics and metabolic engineering

General concepts of metabolism Introduction to databases from plant transcriptomics to

metabolomics

Unit VI

Industrial applications

Industries engaged in tissue cultureplant cell suspension culture their working and management

Pharmaseutically useful metabolites generated by suspension cultures

Text books

1 Dixon RA and Gonzales Plant Cell Culture A Practical Approach IRL Press 1995

2 Lindsey K and MGK Jones Plant Biotechnology in Agriculture Prentice Hall New Jersey

1990

3 Biotol series In vitro Cultivation of Plant cell Butterworth Heinemann Ltd 1994

4 Ranga MM Animal Biotechnology (3e) Agrobios 2007

5 Bhojwani amp Rajdhan Animal and Plant Biotechnology Elsevier 1996 )

6 Gene cloning amp DNA Analysis An introduction by T A Brown Fourth edition (2001)

7 Genetic Engineering by S Rastogi and N Pathak Publishers Oxford University Press(2009)

8 Principles of Gene Manipulation amp Genomics by Primrose amp Twyman Seven edition (2006)

BT- 572 Bioinstrumentation

Unit I

Electrochemistry Temperature pH buffers Conductivity Dissolved oxygen carbon dioxide

Unit II

Centrifugation Basic principle and application Analytical and Preparative centrifuges and ultra

centrifugation

Unit III

Electrophoretic Techniques Paper and gel electrophoresis Immuno electrophoresis isoelectric

focussing two-dimensional electrophoresis capillary electrophoresis

Unit IV

Chromatographic Methods Paper TLC gas chromatography gel filtration ion exchange

chromatography affinity chromatography and HPLC FPLC

Unit V

Spectroscopy UVvisible and NIR spectrofluorimetry Atomic absorption spectrophotometryMass

Spectrometry Infrared and Raman SpectroscopyNuclear Magnetic Resonance and Electron Spin

Resonance spectroscopy

Unit VI

Microscopy Principle parts types and functioning of Microscope Optical and Electron

Microscopy Transmission and Scanning Electron Microscopy Tunneling Electron Microscopy

Atomic Force Microscopy Fluorescence microscopy Confocal microscopy

Text books

1 Principles and Techniques of Practical Biochemistry by Keith Wilson and JohnWalker Cambridge

University Press

2 Biophysical Chemistry The conformation of Biological Macromolecules by CRCantor and PR

Schimmel Publisher WH Freeman

Reference books

1 Essentials of Biophysics by P Narayanan Publishers New Age InternationalPublishers

2 Introduction to Spectroscopy by DL Pavia GM Lampman and G S Kriz Publisher Brooks

Cole

3 Physical Chemistry of Macromolecules by C Tanford Publisher John Wileyand Sons Inc

4 Principles of Physical Biochemistry by KE Van Holde Publisher Prentice Hall

BT-524 Lab- Bioinstrumentation 1 Measurement and control of pH 2 Measurement of conductivity of a given sample

3 Measurement of conductivity and dissolved oxygen in given sample

4 Protein quantification

5 Protein separation through electrophoresis

6 Sample preparation for light microscopy and Electron Microscopy

7 Quantification of DNA RNA Lipid Fatty acids

8 Sample analysis through AAS

9 Sample preparation for Fluorescence and Confocal microscopy

10 Isolation of DNA and analysis by gel electrophoresis

BT-573 Lab- Food Engineering and Biotechnology

1 Isolation of industrially important microbes

2 Production of fermented product

3 Comparative studies of ethanol production using different substrates

4 Production of wine

5 Production of citric acid

6 Detection of adulterants in food

7 Mushroom cultivation

8 Bread making

9 Colourant production

10 Studies of different methods of food preservation

11 Estimation of carbohydrates and proteins

BT-574 Self Study Open Area Seminar-I

SEMESTER II BT- 621 Biopharmaceuticals

Unit-I

Drug metabolism Oxidation reduction hydrolysis conjugation Need for developing new drugs

Procedure followed in drug design Molecular modification of lead compounds Prodrug and soft

drugs Physico-chemical parameters in drug design QSAR Active site determination of enzymes

Design of enzyme inhibitors

Unit-II

Pharmacokinetics and Drug discovery

Biotransformation of drugs Preclinical Pharmacokinetics Compartment modelingone compartment

open model two compartment open model multi compartment model non linear kinetics

bioavailability and bioequivalence excretion of drugs pharmacokinetics ndash effects of food and

fasting Substances derived from bacteria plants insects and animals Sources of active principles

Assay systems and models (eg Knock-out Mice) Protein molecular modeling by computer

Docking studies Structure based drug designing using software

Unit-III

Pharmaceutical dosage forms

Dosage Forms and Basic Preparations Excipients for Pharmaceutical Dosage Forms Compressed

tablets wet granulation dry granulation or slugging direct compression tablet formulation coating

capsules sustained action dosage form parental oral liquids ointments recombinant blood products

and therapeutic enzymes hormones of therapeutic interest Pharmaceutical products Analysis and

Control laxatives ndash analgesics ndash non steroidal contraceptives ndash external antiseptics ndash antacids and

other antibiotics ndash biological ndash hormones ndash vitamins - preservation analytical methods and test for

various drugs and pharmaceuticals packaging techniques ndash quality control

Unit-IV

Pharmaceutical products and products of DNA technology

Microbial products - Antibiotics (penicillin streptomycin tetracycline) vitamins probiotics Plant

secondary metabolites - control mechanism and manipulation of pheny-propanoid pathway and

shikimate pathway Tissue culture production of alkaloids flavanoids steroids terpenoids animal

vaccines Pharmaceutical products of DNA technology Therapeutic proteins ndash Insulin human

growth hormone clotting factors interferons interleukins tissue plasminogen activators

erythropoietin DNAseI alginate lyase muteins Production advantages limitations and applications

of monoclonal antibody Oligonucleotides and Gene therapy ras-Antisense therapy gene delivery

system Vector usage strategies for gene therapy Clinical trials

Unit-V

Drug safety evaluation

Strategy and Phasing for Drug Safety Evaluation in the Discovery and Development of

Pharmaceuticals Regulation of Human Pharmaceutical Safety Acute Toxicity Testing in Drug

Safety Evaluation Special Concerns for the Preclinical Evaluation of Biotechnology Products

Immunotoxicology in Pharmaceutical Development The Application of In Vitro Techniques in Drug

Safety Assessment Pharmaceutical Quality Assurance

Unit-VI

Patenting process in drug manufacturing process

Patenting- Patent types The patent application Patenting in biotechnology Preclinical trials Clinical

trials The role and remit of regulatory authorities-The Food and Drug Administration The

investigational new drug application The new drug application European regulations Guides to

good manufacturing practice Formulation and Delivery Issues of Therapeutic Proteins

Biotechnology-Derived Drug Products Formulation Development Stability Testing Filling and

Packaging

Text books

1 Heinrich Klefenz Industrial pharmaceutical biotechnology John Wiley sons 2002

2 Susanna Wu-Pong Yongyut Rojanasakul and Joseph Robinson Biopharmaceutical drug and

design and development Humana Press 2007

3 Gary Walsh Biopharmaceuticals Biochemistry and Biotechnology (2e) John Wiley amp Sons

2003

4 Herbert A Kirst Wu-Kuang Yeh Milton J Enzyme Technologies for pharmaceutical and

biotechnological applications WILEY-VCH Verlag 2003

BT- 6221 Bioprocess Engineering

Unit I

Media design and Sterilization kinetics

Criteria for good medium medium requirements for fermentation processes carbon nitrogen

minerals vitamins and other complex nutrients oxygen requirements medium formulation of

optimal growth and product formation examples of simple and complex media medium

optimization methods ndash Plackett and Burman and Response surface method Thermal death kinetics

of microorganisms batch and continuous heat sterilization of liquid media design of sterilization

equipment-batch and continuous ilter sterilization of liquid media air sterilization

Unit II

Metabolic stoichiometry and energetics

Stoichiometry of cell growth and product formation elemental balances degrees of reduction of

substrate and biomass available electron balances yield coefficients of biomass and product

formation maintenance coefficients energetic analysis of microbial growth and product formation

oxygen consumption ndash steps involved in the transfer of oxygen to broth and heat evolution in aerobic

cultures

Unit III

Growth and Production kinetics

Kinetic models for microbial growth Monod model growth of filamentous organisms product

formation kinetics - leudeking-piret models substrate and product inhibition on cell growth and

product formation Production kinetics Design for single and multiple reaction size comparisons of

single reactor for single reactions multiple reactor systems for single reaction reactions in parallel

in series and seriesparallel reactions of first order Heterogeneous reactions kinetics and mechanism

of heterogeneous non catalytic and catalytic reactions Non ideal flow - residence time distribution

studies CE F and I curves RTD in ideal reactors Models for Non ideal flow ndash zero ndash parameter

model One parameter model and two parameter model

Unit IV

Types and design of bioreactor

Construction material Basic components ndash Agitator aerator valves and steam traps seals stirrer

glands Stirred tank batch bioreactor stirred batch bio reactor for enzymes cell cultures Continuous

Stirred Tank Bioreactor Continuous operation of mixed reactor enzyme reactions in a mixed

reactor substrate inhibition kinetics and product inhibition kinetics chemostat with cell cultures ndash

steady state cell and substrate concentrations and productivity as a function of dilution rate CSTR

with immobilized enzymes operation of CSTR in a constant feed rate policy-simulation for

conversions with and without diffusion limitations chemostat in series Graphical design Plug Flow

and Packed Bed Bioreactor Performance equation with Michelin-Menten kinetics substrate

inhibition and product inhibition plug flow reactor for immobilized enzymes operation of plug flow

reactor in constant feed rate policy simulation for conversion with and without diffusion limitations

Fedndashbatch reactor Applications of fed reactor Fed batch operation of mixed reactor material

balance on cell and substrate Recycle system Chemostat with recycle Biological waste water

treatment Feed forward control of the activated sludge process The Transient Behavior of

Bioreactors Stability analysis Stability of the chemostat Stability of chemostat with substrate

inhibition Operating diagram Transient responses of the chemostat control of the chemostat

Turbidostat operation Nutristat operation

Unit V

Instrumentation and Control

Biochemical process variables and their measurements Control principles and their application in

bioreactors Theory of electrode processes and their applications Measurement and control of pH

temperature dissolved oxygen aeration and agitation redox potential foam etc On-line analysis of

process parameters Introduction to biosensors Transduction principles used in biosensors

Characteristics of biosensors Biosensors based on amperometric potentiometric thermistor FET

fiber optics and bioluminescence Microbial biosensors Fundamentals of digital process control Use

of computer in control and optimization of microbiological processes

Unit VI

Downstream processing

Removal of microbial cells and solid matter foam separation precipitation filtration centrifugation

cell disruptions liquid-liquid extraction chromatography membrane process drying and

crystallization Quality analysis and product formulation - Product appearance product stabilization

shelf life analysis usage specific formulations quality analysis and control

Text books

1 Biochemical Engineering Fundamentals by JE Baily and DF Ollis Publisher McGraw Hill

(1986)

2 Biochemical Engineering by SAiba AE Humphry and NF Millis Publisher University of

Tokyo press(1973)

3 Bioreaction engineering principles by J Nielson and J Villadsen Publisher Plenum Press (1994)

4 Chemical Engineering Design Fourth edition by JM Coulson and JF Richardson Publisher

Butterworth Heinemann(2005)

5 Bioprocess Engineering- Kinetics Mass transport reactors and gene expression by WR Veith

Publisher John Wiley and Sons Inc(1994)

6Bioprocess Engineering Basic Concepts by ML Shuler and F Kargi Publisher Prentice Hall

(1987)

7Bioprocess engineering principles by P Doran Publisher- Academic press (1995)

BT-6231 Biosensor Unit-I

Introduction

A historical perspective Definition and Expanding Needs of Biosensors Advantages and limitations

Biosensor Economics various components of biosensors

Unit-II

Types of Biosensors

Biocatalysts based biosensors bio affinity based biosensors amp microorganisms based

biosensors biologically active material and analyte Types of membranes used in

biosensor constructions

Unit-III

Transducers in Biosensors

Various types of transducers principles and applications Bio- chemi- and lectrochemiluminescence

for fiber-optic biosensors Fluorescence-based fiber-optic biosensors

Unit-IV

Electrical Signal Detection in Biological Systems

Silicon glass and metal electrodes amplifier design Bioelectronic device production

microelectronic fabrication methods as adapted to bioelectronics hard and soft lithography bio-

compatibility of materials Existing types of Biosensors Miniaturisation and micro-systems

including sensing using optical techniques field effect transistors ion-selective and enzymatic

sensitive electrodes as well as impedance monitoring

Unit-V

Kinetic modeling for biosensors

The purpose and practice of modeling The flux equations The flux diagram for the membrane

enzyme electrode Deriving a complete kinetic model Kinetic modeling in other types of

biosensors- Potentiometric enzyme electrodes Optical and photometric biosensors Immunosensors

Unit-VI

Application and Uses of Biosensors

Biosensors in medicine and health care (For glucose monitoring and for DNA analysis Analysis of

the neural cell impulse signal and neural signal processing) biosensors for agriculture and food Low

cost- biosensor for industrial processes for online monitoring biosensors for environmental

monitoring

Text books

1 Rajmohan Joshi Biosensors (1e) Gyan Books 2006

2 Cooper JM and Anthony EG Biosensors (2e) Oxford University Press 2004

3 Turner APF KarubeI and WilsonGS Biosensors Fundamentals and applications Oxford Univ

Press 1990

4 SadanaA Biosensors Kinetics of Binding and Dissociation Using Fractals (1e) Elsevier BV

1995

5 Ashok M and Kim Rogers Enzyme amp Microbial Biosensors Techniques and Protocols (Methods

in Biotechnology) (1e) Humana Press 1998

6 Ashok M and Kim Rogers Affinity Biosensors Techniques and Protocols (Methods in

Biotechnology) (1e) Humana Press 1998

7 Damia Barcelo Biosensors for the Environmental Monitoring of Aquatic Systems Bioanalytical

and Chemical Methods for Endocrine Disruptors (1e) Springer 2009

BT-6711 Nanobiotechnology

Unit-I

Introduction

Nano - definition The fundamental Science behind nanotechnology- electrons atomsand ions

molecules metals biosystems Synthesis and Characterizations of Nanoscale Materials Strategies for

Nano architecture (top down and bottom up approaches) Fabrication Technologies and

Characterizations Self-assembly Systems Basic aspects of Nanofluidics surfactants polymers

emulsions and colloids Nanoscale Artificial Platforms Lipids in Self-assembly Structures

Nanoparticle synthesis in plants bacteria and yeast and its applications

Unit-II

Nano-structured materials

Fullerenes - Properties and CharacteristicsCarbon Nanotubes - Characteristics and Applications

Quantum Dots and WiresGold Nanoparticles Nanopores carbon nanotubes Applications of

NanoMolecules in Biosystems

Unit-III

Structural and functional principles of nanobiotechnology

Structural principle Factors governing biomolecular structure and stability Protein folding Self

assembly Self-organization Molecular recognition and Flexibility of biomaterials Functional

principles of Bionanotechnology Information driven nanoassembly Energetics Role of enzymes in

chemical transformation allosteric motion and covalent modification in protein activity regulation

Structure and functional properties of Biomaterials Bimolecular motors ATP Synthetase and

flagellar motors Traffic across membranes Potassium channels ABC Transporters and

Bactreriorhodapsin Bimolecular sensing Self replication Machine-Phase Bionanotechnology

Unit-IV

Bionanomachines and their Basic

Negligible gravity and inertia atomic granularity thermal motion water environment and their

importance in bionanomachines The role of proteins amino acids nucleic acids lipids and

polysaccharides in modern biomaterials Overview of natural Bionanomachines Thymidylate

Sythetase ATP synthetase Actin and myosin Opsin Antibodies and Collagen

Unit-V

Biophotonics and Bioimaging

Overview of imaging biological systems from the cellular level through to wholebody medical

imaging Introduction to biophysics basic physical concepts in imaging Major techniques using

ionizing and non-ionizing radiation fluorescence and multi-photon microscopy spectroscopy OCT

MRI X-ray CT PET and SPECT imaging

Unit-VI

Application of Nanobiotechnology

Nano-biotechnology in drug Delivery Nanoscale Devices for Drug Discovery Micelles for Drug

Delivery Protein targeting Small Molecule-Protein Interactions Micro-array and Genome Chips

Nanotechnology and the Cell Cell Motility Nano Motors and Cellular Navigation hemotaxis -

Transmembrane Signalling and Related Protein Nanotechnology for Cancer Diagnostics and

Treatment Nanotechnology for Cancer Research and Therapy siRNA Tumor-targeted Drug

Delivery Systems Nanotechnology for Imaging and Detection

Text Books

1 NANO by TPradeep 2006Tata Mc Graw Publishers India

2 Nanobiotechnology Concepts Applications and Perspectives Christof MNiemeyer Chad

AMirkin (eds) Wiley-VCH Weinheim (2004)

3 Kamali Kannangara Geoff Smith Michelle Simmons Burkhard Raguse

4 Overseas Press (2005)

5 David S Goodsell Bionanotechnology John Wiley amp Sons 2004

6 Greco Ralph S Nanoscale Technology in Biological Systems CRC Press 2005

BT-6721 Environmental Biotechnology

Unit-I

Basic concepts of ecology Interaction between environment and biota Concept of habitat and

ecological niches Limiting factor Energy flow food chain food web and trophic level NPC and S

cycles in nature Ecosystem dynamics and management Environmental impact assessment

Principles of conservation Conservation strategies sustainable development Global environmental

problems ozone depletion UV-B radiation green house effect and acid rain their impact in

biotechnological approaches for management

Unit-II

Environmental pollution

Types of pollution and pollution analysis ndash noise air and gaseous pollution Noise pollution Source

measurement impact on ecosystem and control Air pollution Types source method of sampling

measurement impact on ecosystem and control Control of noise and air pollution by

biotechnological methods Gaseous pollutants and odours General sources methods of control

fundamentals of adsorption mechanism of adsorption equilibrium isotherms break through curve

adsorption equipment regeneration of adsorbent application of adsorption for control of gaseous

and odour emission

Unit-III

Water pollution Impurities in water water pollution by industrial waste examination of water

collection of water samples water analysis ndash physical chemical and biological Standards of water

quality Water treatment processes Primary treatment screening skimming with coagulants

flocculation filteration aeration and disinfection Secondary treatment Aerobic processes ndash

activated sludge oxidation ditches recirculating system trickling filter towers rotating discs

rotating drums oxidation ponds Anaerobic digestion anaerobic filters Up flow anaerobic sludge

blanket reactors Tertiary treatment Activated carbon treatment reverse osmosis and electro dialysis

Unit-IV

Bioremediation

In situ and ex situ bioremediation technologies for various pollutants and sites bioremediation of oil

spills and heavy metal pollution use of microbes in bioremediation hydroponic system pollution

control boards and pollution control acts

Unit-V

Solid waste management sewage sludge treatment and utilization refuse disposal excreta disposal

in unsewered area composting and vermiculture biodegradation of noncellulosic wastes for

environmental conservation and fuel bioconversion of cellulosic wastes into protein and fuel

bioremediation of contaminated soils and waste lands radioactive product waste disposal

Unit-VI

Effluent treatment Sources of pollution impact on ecosystem and treatment of following industrial

effluents starch paper and pulp tannery dairy distillery oil refineries and pharmaceutical

Microbes in mining ore leaching oil recovery biopolymers biosurfactants

Text Books

1 Bruce E Rittmann and perry L Mccarty ldquoEnvironmental Biotechnology Principle and

Applicationsrdquo McGraw Hill publishing company Ltd2001

2 Mecalf and Eddy Inc ldquoWastewater Engineering Treatment Disposal Reuserdquo McGraHill

publishing company Ltd1991

3 Des W Connell ldquoBasic concepts of Environmental chemistryrdquo Lewis publishers2005

4 Michal J PelczarECS ChanNoel RKriegTata McGraw Hill publishing company Ltd1993

5 Alan Scragg Environmental BiotechnologyOxford University press2005

6 Prescott Harley Klein Microbiology WCB publishers1996

7 Richard T Wright and Bernard J Nebel ldquoEnvironmental Science towards a Sustainable Futurerdquo

Prentice Hall of India 2004

BT-624-Bioprocess Engineering Lab

1 To determine the concentration of protein content by Lowry method

2 To determine the concentration of sugar by 3 5 dinitrosalicylic acid method

3 To determine the optimum pH for given enzyme sample

4 To determine the optimum temperature for given enzyme sample

5 To study the immobilization of invertase enzyme

6 Measurement of citric acid production by Aspergillus niger with TLC

7 Determination of thermal death point (TDP) of the given microorganism

8 Production of ethanol from yeast fermentation of sugars

9 To prepare the growth curve of micro-organism cultured in a shake flask

10 To study the kinetics of lipase enzyme

BT-673- Environmental Biotechnology Lab 1 Environmental Impact Assessment Measurement of Air and Noise Pollution

2 Analysis of water temperature and pH

3 Measurement of Conductivity and TDS in water

4 Measurement of Dissolved Oxygen

5 Measurement of Carbondi Oxide and Hardness of water

6 Measurement and analysis of Ammonia and Ammonium in water

7 Measurement of Nitrite Nitrate and Total Nitrogen in water

8 Biochemical Oxygen Demand and Chemical Oxygen Demand measurements and analysis

9 Analysis of any one industrial effluent

10 Production of methane from sewage sludge

11 Vermicomposting

BT-674 Minor Project- I

SEMESTER III

BT-721 1 Elective ndash Bioseparation Technology Unit- I

Role of Downstream Processing in Biotechnology

Role and importance of downstream processing in biotechnological processes Problems and

requirements of bioproduct purification Economics and downstream processing in Biotechnology

Cost cutting strategies characterstics of biological mixtures process design criteria for various

classes of bioproducts (high volume-low value products and low volume- high value products)

physicochemical basis of bioseparation processes

Unit- II

Primary Separation and Recovery Processes

Cell disruption methods for intracellular products removal of insolubles biomass (and particulate

debris) separation techniques flocculation and sedimentation centrifugation and filtration methods

Precipitation methodsPrecipitation with salts organic solvents amp polymers

Unit- III

Extraction

Batch extractions staged extractions-cross current co current counter current extractions

Differential extractions fractional extractions with a stationary phase fractional extractions with two

moving phases Aqueous two-phase extraction reverse micelle extraction supercritical fluid

extraction in-situ product removalintegrated bioprocessing

Unit- IV

Membrane-based separations (micro- and ultra-filtration)

Theory design amp configuration of membrane separation equipment applications

reverse osmosis dialysis electro dialysis Isoelectric focusing

Unit- V

Adsorption

Adsorption isotherms industrial adsorbents adsorption equipments for batch and continuous

operations (co current and counter current) adsorption in fixed beds

Unit- VI

Chromatography

Principles of chromatographic separation ndash gel filtration reversed phase hydrophobic interaction

ion-exchange expanded bed adsorption bio affinity and IMAC supercritical fluid chromatography

Text books

1 Belter PA Cussler E and Wei Shan Hu Bioseparation ndash Downstream Processing for

Biotechnology Wiley Interscience 1988

2 Asenjo and Juan A Asenjo Separation Processes in Biotechnology CRC Press 1990

3 Wankat PC Rate Controlled Separation Kluwer Publishers 1990

4 Wang DIC Cooney CL Demain AL DunnilP Humphery AE and Lilly MD Fermentation

and Enzyme Technology John Wiley and Sons 1979

BT-721 2 Elective - Industrial Waste water treatment

UNIT I

Waste disposal management Methods of waste disposal industrial waste (solid liquid and gaseous

emission) effect of industrial wastes on streams and sewerage systems Treatment system of waste

disposal eg Incenerator differences in waste quality and quantity physico-chemical and biological

treatments of waste and their evaluation in respect of treatment

UNIT II

Characteristic features of wastes (solid liquid and gaseous emission) manufacturing processes and

toxic byproducts generated from iron ore alumina heavy metals units paper and pulp industries

pesticides industry thermal power station distillery textile and crude oil industry

UNIT III

Small and large scale industries for waste reduction and remediation various methods for waste

alteration volume and strength minimization recycling plants material restoration and conservation

Methods for neutralisation equalization precipitation and solidification for waste handling

Economic sustainability and government support for joint treatment of raw effluent municipal

sewage and debris

UNIT IV

Unit operations and their design for treatment and management of wastes (solid liquid and gaseous)

UNIT V

Landfill design and operation including site selection engineered sites liners and covers leachate

control and treatment gas recovery and control including utilization of recovered gas (energy) and

landfill monitoring and reclamation

UNIT VI

Case studies

Text Books

1 S P Mahajan ldquoPollution Control in Process Industriesrdquo Tata Mc Graw Hill Publications

2 W Wesley Eckenfelder Jrrdquo Industrial Water Pollution Controlrdquo Mc Graw Hill Publications

3 Ronald W Crites Sherwood C Reed and Robert Bastion ldquoLand Treatment Systems for Municipal

amp Industrial Wastesrdquo Mc Graw Hill Publications

4 Neal K Ostler ldquoIndustrial Waste Stream Generationrdquo Prentice Hall

5 Rao and Dutta ldquoIndustrial waste treatmentrdquo Oxford and IBH Publishing Co Pvt Ltd New Delhi

6 Dr A D Patwardhan ldquoindustrial Waste Water Treatmentrdquo Prentice Hall of India

BT-721 3 Elective-Biopolymer Technology Unit-I

Introduction

Biopolymers ndash The current scenario different biopolymers ndash produced from various renewable

resources characteristics merits and demerits over conventional polymers

Unit-II

Biopolymer Technology and Applications

Biopolymers and Artificial Biopolymers in Biomedical Applications an Overview Novel Synthesis

of Biopolymers and Their Medical Applications Composite Films Based on Poly (Vinylalcohol) and

Lignocellulosic Fibres Preparation and Characterizations Composite Materials Based on Gelatin

and Fillers from Renewable Resources Thermal and Mechanical Properties Properties of PHAs and

Their Correlation to Fermentation Conditions

Unit-III

Biosynthesis and Modifications

Synthesis and modification of different Biopolymers like xanthum gum

Unit-IV

Biosurfactants

Source characteristics and properties of Biosurfactants Production of Biosurfactants via the

fermentation and biotransformation routes Production of Biosurfactants with immobilized cells

Integrated bioprocess for continuous production of Biosurfactants including downstream processing

Applications of Biosurfactants-Food Industry Environmental Control

Unit-V

Bioplastic

Different types of bioplastics Starch-based plastic Cellulose-based plastic Aliphatic polyesters

Poly-3-hydroxybutyrate (PHB) Polylactic acid (PLA) Polyamide Bio-derived polyethylene

Advantages of bioplastic over petroleum-based polymer Mechanism of synthesis of Poly (-

hydroxybutyric acid) (PHB)

Unit-VI

Material Testing and Analytical Methods

An Overview of Available Testing Methods Comparison of Test Systems for the Examination of the

Fermentability of Biodegradable Materials Structure- Biodegradability Relationship of biopolymers

Text Books

1 Emo Chiellini Emo Chiellini and Helena Gil Biorelated Polymers Sustainable Polymer Science

and Technology Springer 2001

2 Johnson RM LY Mwaikambo and N Tucker Biopolymers Rapra Technology 2003

3 Naim Kosaric (Ed) Biosurfactants Marcell Dekker Inc 1993

BT-721 4 Elective ndash Bioprocess Plant Designing Unit-I

Process development

Introduction to Design ndash nature of design ndash Technical feasibility survey Mass and energy balance

process development ndash data acquisition ndash design data information of project - Organization of project

ndash Project documentation ndash codes and standards

Unit-II

Design Development

Equipment selection and specifications-materials of construction ndash flow sheeting - piping and

instrumentation ndash process safety and loss prevention

Unit-III

General site consideration

Introduction ndash plant location and site selection ndash site layout- plant layout utilities ndash environmental

considerationsndash waste management ndash visual impact ndash government regulations and other legal

restrictions community factors and other factors affecting investment and production costs ndash human

resources

Unit ndashIV

Selection and specification

Selection and specification of equipment for handling fluids and solids Selection specification

design of heat and mass transfer equipment used in bioprocess industries Design of facilities for

cleaning of process equipment used in biochemical industries Utilities for biotechnology

Unit-V

Design of fermenters

Design of fermentation Design considerations for maintaining sterility of processing equipment

Unit-VI

Process economics

Production plants Bioprocess validation Safety considerations

Text books

1 Applied Process Design for Chemical and Petrochemical Plants by EE Ludwig Publisher

Butterworth-Heinemann

2 Chemical Engineering by RK Sinnott JM Coulson and JF Richardsons Publisher

Butterworth-Heinemann Vol-6 Butterworth Heinemann III editionndash 2002

3 Peters and Timmerhaus Plant Design and Economics for Chemical Engineers Mcgraw Hill

4thEdition 1989

4 Rudd and Watson Strategy of Process Engineering Wiley 1987

BT-721 5 Elective- Transport Phenomenon Unit -I

Diffusion

Molecular and turbulent diffusion Diffusion coefficient Flickrsquos Law of diffusion Dependence of

diffusion coefficient on temperature pressure and composition Diffusion in multi-component gas

mixtures Diffusion in solids Molecular Knudsen ampsurface diffusion Inter- phase mass transfer

Mass transfer coefficients Diffusion between phases Equilibrium solubility of gases in liquids

Mass Transfer theories Mass transfer in fluidized beds flow past solids and boundary layers

Simultaneous heat and mass transfer Mixing in a Bioreactor -Flow regimes with and without baffles

various types of impellers and mixing equipment Power Requirements for Mixing Ungassed

Newtonian Fluids Gassed Fluids Improving Mixing in Fermenters Effect of Rheological Properties

on Mixing Role of Shear in Stirred Fermenters

Unit-II

Drying and Crystallization

Solid-gas equilibria Different modes of drying operation Types of batch and continuous dryer

Definitions of moisture contents Rate of batch drying Time of drying Mechanism of batch drying

Continuous drying Equilibrium yield of crystallization Heat and mass transfer rates in

crystallization Theories of crystallization Factors governing nucleation and crystal growth rates

controlled growth of crystal Classification of crystallizers

Unit ndashIII

Absorption and Adsorption

Gas-Liquid equilibriaHenryrsquos Law Selection of solvents Absorption in tray column Graphical and

analytical methods Absorption in packed column Design equation for packed column HTU NTU

and HTEP concepts Equipments Description of adsorption process and their application Types of

adsorption Nature of adsorbents Adsorption equilibrium and adsorption hysterises Stage wise and

continuous contact adsorption operation operations Determination of number of stages Equipments

Unit-IV

Momentum transfer

Review of basic concepts ndash Conservation of Mass Conservation of Energy Momentum Balance ndash

Momentum Balance in a Circular Pipe Flow Velocity Profile Fermentation Broth Rheology ndash

Viscosity Rheological Properties of Fermentation Broths Factors affecting broth viscosity

Unit V

Conduction and Convection

Introduction Conduction Basic concepts of conduction in solids liquids and gases One and two

dimensional heat conduction Critical and optimum insulation thickness Introduction to unsteady

state heat transfer Principles of convection Equations of forced and free convection

Unit ndashVI

Radiation

Basic laws of heat transfer by radiation black body and gray body concepts solar radiations

combined heat transfer coefficients by convection and radiation Introduction of Heat Transfer

Equipments Heat Exchangers Evaporators Condenser

Text Books

1 Holman JP ldquoHeat Transferrdquo 9 th ed McGraw Hill (1989)

2 Treybal R ldquoMass Transfer Operationsrdquo 3rd ed New York McGraw-Hill (1980)

3 McCabe Smith Unit Operations in Chemical Engineering McGraw Hill

4 Foust A S etal ldquoPrinciples of Unit Operationsrdquo John Wiley (1980)

5 R B Bird et al Transport Phenomena 2nd Edition Wiley(2006)

BT-721 6 Elective ndash Biochemical thermodynamics Unit-I

Fundamental concepts of Thermodynamics

System and Surroundings First law of thermodynamics -Internal energy enthalpy Heat capacity

applied examples from biochemistry Second law ndash Entropy and universe Concept of heat engines

protein stability and calorimetric measurements Fundamentals of Differential scanning calorimeter

and Isothermal calorimeter in biological property measurements Third law of thermodynamics

Maxwell equations Gibbs-Duhem Equation and the Phase Rule Legendre Transforms

Unit-II

Non-equilibrium Thermodynamics

Reversible work exact differentials and function of state first and second law The electrochemical

potential External forces and steady state Fickrsquos Law chemical reactions in the steady state internal

entropy production cells as non-equilibrium stationary states Diffusion and membrane transport

Biological Systems as Open Non-equilibrium Systems Failure of classical thermodynamics in

describing biological processes Standard free energy changes and equilibrium constants direction

and rate

Unit-III

Bioenergetics

Energetics of metabolic pathways ndash energy coupling (ATP amp NADH) stoichiometry ndashenergetic

analysis of cell growth and product formation ndash elemental balances Degree ofreduction concepts

available- electron balances yield coefficients oxygen consumptionand heat evolution in aerobic

cultures thermodynamic efficiency of growth Thermodynamics of Biological Systems

Thermodynamic analysis of oxidative photophosphorylation stability of non-equilibrium stationary

states ordering in time and space far from equilibrium glycolytic oscillations Biological clocks

routes to chaos

Unit-IV

Chemical Potential

Visualization of the potential Steady velocity and steady flow Fickrsquos law and diffusion Local

Equilibria and Steady State Energy vs Power Transducers in biological states Constitutive

equations Dynamic efficiency and Onsager (nonequilibrium thermodynamics) Prigoginersquos principle

Spontaneous coupling and entropy production

Unit-V

Gibbs free energy and its Applications

Gibbs free energy and equilibrium Chemical potential ionic solutions Equilibrium constant

standard state in biochemistry Acid and bases chemical coupling and redox reactions Gibbs free

energy in photosynthesis glycolysis citric acid cycle Oxidative phosphorylation and ATP

hydrolysis substrate cycling Membrane transport Enzyme substrate interaction Haemoglobin

Protien solubility stability and dynamics

Unit-VI

Reaction Kinetics

Rate of a reaction rate constant and order of the reaction effect of temperature collision and

transition state theory Electron transfer kinetics Enzyme kinetics and inhibition Reaction

mechanism of lysozyme protein folding and pathological misfolding polymerisation muscle

contraction and the molecular motors

Text Books

1 Smith JM Van Ness HC Abbot MM Chemical Engineering Thermodynamics 6th Edition

McGraw-Hill 2001

2 Narayanan KV A Text Book Of Chemical Engineering Thermodynamics Prentice Hall India

2001

3 Sandler SI Chemical And Engineering Thermodynamics John Wiley1989

4 Bailey amp Ollis Biochemical Engineering Fundamentals II edition Megraw Hil ndash 1986

5 Donald T Haynie Biological Thermodynamics Cambridge press 2008

6 Robert A Alberty Thermodynamics of Biochemical Reactions John willy publications 2003

7 Bioenergetics by AL Lehninger Publisher WA Benjamin Inc

8 Biological Thermodynamics by DT Haynie Publisher Cambridge University Press

9 Biophysical Chemistry by CR Cantor and PR Schimmel Publisher

10 FreemanThermodynamics and Kinetics for the Biological Sciences by GG Hammes Publisher

John Wiley and Sons Inc

BT-7221 Elective - Bioethics Biosafety and IPR Unit I

Introduction to ethics and bioethics

Personal ethics profession and professionalism -Moral Reasoning -Ethical theories - person as an

experimenter -Moral leadership (integrity and ingenuinity) ndash framework for ethical decision making

Biotechnology and ethics Biotechnology in agriculture and environment benefits and risks ndash

benefits and risks of genetic engineering ndash ethical aspects of genetic testing ndash ethical aspects relating

to use of genetic information ndash genetic engineering and biowarfare

Unit-II

Ethical implications of cloning

Reproductive cloning therapeutic cloning Ethical legal and socio-economic aspects of gene

therapy germ line somatic embryonic and adult stem cell research- GM crops and GMO‟s ndash

biotechnology and biopiracy ndash ELSI of human genome project

Unit-III

Introduction to biosafety

Biosafety issues in biotechnology ndash risk assessment and risk management ndash safety protocols risk

groups ndash biosafety levels ndash biosafety guidelines and regulations (National and International) ndash

operation of biosafety guidelines and regulations ndash types of biosafety containment International

guidelines with regard to rDNA technology transgenic science GM crops etc Experimental

protocol approvals levels of containment Guidelines for research in transgenic plants Good

manufacturing practice and Good lab practice (GMO and GLP)

Unit-IV

Introduction to intellectual property and intellectual property rights

Types patents copy rights trade marks design rights geographical indications ndash importance of IPR

ndash patentable and non patentables ndash patenting life ndash legal protection of biotechnological inventions ndash

world intellectual property rights organization (WIPO) Plant breederrsquos rights Legal implications

Biodiversity and farmers rights Examples of patents in biotechnology Special application of patent

laws in biotechnology Licensing and cross licensing Flavr SavrTm- Tomato as model case and case

studies

Unit-V

Public acceptance issues for biotechnology

Environmental aspects of biotech application Use of genetically modified organisms and their

release in environment Case studies or experiences from developing and developed countries

Biotechnology and hunger Challenges for the Indian Biotechnological research and industries

Unit-VI

Socioeconomic impacts of biotechnology

The legal and socioeconomic impacts of biotechnology public education of the processes of

biotechnology involved in generating new forms of life for informed decision making

Text Books

1 Ethics in engineering Martin MW and SchinzingerR III Edition Tata McGraw- Hill New

Delhi 2003

2 Biotechnologies and Development UNESCO Publications 1988

3 A Biotechnologies in developing countries present and future UNESCO Publishers 1993

4 Singh K Intellectual property rights on Biotechnology BCIL New Delhi

BT-722 4 Elective ndash Metabolic Engineering Unit ndash I

Cellular metabolism

An overview of cellular metabolism-transport processes- Fueling reactions -glycolysis-fermentative

pathways-TCA cycle and oxidative phosphorylation-anaplerotic pathways -catabolism of fats

organic acids and amino acids -biosynthetic reactions of amino acids ndash nucleic acids fatty acids and

other building blocks -polymerization - growth energetics

Unit ndash II

Comprehensive models for cellular reactions

Stoichiometry of cellular reactions -reaction rates-dynamic mass balances-Yield coefficients and

linear rate equation Material Balance and data consistency ndashblack box model elemental balance -

heat balance -analysis of over determined systems - identification of gross measurement errors

Unit ndash III

Regulation of metabolic pathways

Overview of enzyme kinetics ndash simple reversible inhibition systems ndash irreversible inhibition ndash

allosteric enzymes cooperativity ndash regulation of enzyme concentration ndash transcription initiation ndash

translation regulation at whole cell level ndash regulation of metabolic networks enhancements of

product yield and productivity for ethanol and amino acids pathways metabolic pathway

manipulations to extend substrate range product spectrum and novel products improvement of

cellular properties

Unit ndash IV

Metabolic flux analysis

Theory ndash overdetermined systems ndash underdetermined systems ndash sensitivity analysis ndash methods for the

experimental determination of metabolic fluxes by isotope labeling direct flux determination from

fractional enrichment ndash applications involving complete enumeration of metabolite isotopomers ndash

carbon metabolite balances Applications of metabolic flux analysis ndash amino acid production by

Glutamic acid Bacteria

Unit ndash V

Metabolic control analysis

Fundamentals of Metabolic control analysis -determination of flux control coefficients ndash MCA of

Linear pathways ndash branched pathways ndash theory of large deviation

Unit-VI

Applications of metabolic engineering

Text Books

1 Gregory N Stepanopoulos Aristos A Aristidou Jens Nielsen Metabolic Engineeing

2 Principles and methodologies Academic Press 1998

3 Wang DIC Cooney CL Demain AL DunnilP Humphery AE Lilly MD

4 ldquoFermentation And Enzyme Technologyrdquo John Wiley And Sons 1980

5 Zubay G ldquoBiochemistryrdquo Macmillan Publishers 1989

BT-722 3 Elective ndash Protein Engineering Unit-I

Bonds and Energies in protein

Covalent Ionic Hydrogen Coordinate hydrophobic and Vander walls interactions in protein

structure Interaction with electromagnetic radiation (radio micro infrared visible ultraviolet X-

ray) and elucidation of protein structure

Unit-II

Amino acids and their characteristics

Amino acids ndash structure with three and single letter codes- molecular properties (size solubility

charge pKa) Chemical reactivity in relation to post-translational modification (involving amino

carboxyl hydroxyl thiol imidazole groups) and peptide synthesis

Unit - III

Protein architecture

Primary structure peptide mapping peptide sequencing - automated Edman method amp massspec

High-throughput protein sequencing setup Secondary structure Alpha beta and loop structures and

methods to determine Super-secondary structure Aphaturn- alpha beta-turn-beta (hairpin) beta-

sheets alpha-beta-alpha topology diagrams up and down amp TIM barrel structures nucleotide

binding folds prediction of substrate binding sites Tertiary structure Domains folding denaturation

and renaturation overview of methods todetermine 3D structures Quaternary structure Modular

nature formation of complexes

Unit-IV

Structure-function relationship

DNA-binding proteins prokaryotic transcription factors Helix-turn-Helix motif in DNA binding

Trp repressor Eucaryotic transcription factors Zn fingers helix-turn helix motifs in homeodomain

Leucine zippers Membrane proteins and receptors bacteriorhodopsin and Photosynthetic reaction

center Immunoglobulins IgG Light chain and heavy chain architecture abzymes and Enzymes

Serine proteases understanding catalytic design by engineering trypsin chymotrypsin and elastase

substrate-assisted catalysis other commercial applications

Unit -V

Identification and analysis of proteins

Identification and analysis of proteins by 2D analysis Spot visualization and picking Tryptic

digestion of protein and peptide fingerprinting Mass spectrometry ion source (MALDI spray

sources) analyzer (ToF quadrupole quadrupole ion trap) and detector

Unit-VI

Tools in proteomics and genomics

Site directed mutagenesis for specific protein function Basic concept for designing a new

proteinenzyme molecule Specific examples of enzyme engineering Tryesyl t RNA synthetase

Dihydrofolate reductase Subtilisin Advantages ndash protein data base analysis ndash methods to alter

primary structure of proteins examples of engineered proteins thermal stability of T4-lysozyme

recombinant insulin to reduce aggregation and inactivation de novo protein design ndash principles and

examples

Text Books

1 Voet D and Voet G Biochemistry Third edn John Wiley and Sons 2001

2 Moody PCE and Wilkinson AJ Protein Engineering IRL Press Oxford UK 1990

3 Branden C and Tooze J Introduction to Protein Structured Second Edition GarlandPublishing

NY USA 1999

4 Creighton TE Proteins Freeman WH Second Edition 1993

BT-7222 Elective ndash Quality Management Unit-I

Quality Concepts

Definition of Quality Dimensions of Quality Quality Planning Quality costs ndash Analysis

Techniques for Quality Costs Evolution of Quality Control Basic concepts of Total Quality

Management Historical Review Leadership ndash Concepts Role of Senior Management Quality

Council Quality Statements Strategic Planning Deming Philosophy Barriers to TQM

Implementation Control on Purchased Product Procurement of various products evaluation of

supplies capacity verification Development of sources procurement procedure Manufacturing

Quality Methods and techniques for manufacture inspection and control of product quality in sales

and services guarantee analysis of claims

Unit-II

Quality Management

Organization structure and design quality function decentralization designing and fitting

organization for different type products and company economics of quality value and contribution

quality cost optimizing quality cost seduction program Human Factor in quality Attitude of top

management cooperation of groups operators attitude responsibility causes of apparatus error and

corrective methods

Unit-III

Control Charts

Theory of control charts measurement range construction and analysis of R charts process

capability study use of control charts

Attributes of Control Chart

Defects construction and analysis of charts improvement by control chart variable sample size

construction and analysis of C charts

Unit -IV

Defects diagnosis and prevention defect study identification and analysis of defects correcting

measure factors affecting reliability MTTF calculation of reliability building reliability in the

product evaluation of reliability interpretation of test results reliability control maintainability zero

defects quality circle

Unit-V

Statistical process control

The seven tools of quality Statistical Fundamentals ndash Measures of central Tendency and Dispersion

Population and Sample Normal Curve Control Charts for variables and attributes Process

capability Concept of six sigma New seven Management tools

Unit-VI

Quality system

Need for ISO 9000 and Other Quality Systems ISO 90002000 Quality System ndash Elements

Implementation of Quality System Documentation Quality Auditing QS 9000 ISO 14000 ndash

Concept Requirements and Benefits

Text Books

1 Lt Gen H Lal ldquoTotal Quality Managementrdquo Eastern Limited 1990

2 Greg Bounds ldquoBeyond Total Quality Managementrdquo McGraw Hill 1994

3 Menon HG ldquoTQM in New Product manufacturingrdquo McGraw Hill 1992

4 Dale HBesterfiled et at Total Quality Management Pearson Education Asia 1999

5 James REvans amp William MLidsay The Management and Control of Quality (5thEdition)

South-Western (Thomson Learning) 2002 (ISBN 0- 324-06680-5)

6 FeigenbaumAV ldquoTotal Quality Management McGraw-Hill 1991

7 OaklandJS ldquoTotal Quality Management Butterworth ndash Hcinemann Ltd Oxford 1989

8 Narayana V and Sreenivasan NS Quality Management ndash Concepts and Tasks New Age

International 1996

9 Zeiri ldquoTotal Quality Management for Engineers Wood Head Publishers 1991

BT-722 5 ElectivendashDesign and Development of Biological Treatment process

Unit-I

Bacterial metabolism in wastewater treatment systems

Introduction decomposition of organic carbon compounds in natural and manmade systems aerobic

and anaerobic decomposition of glucose protein carbohydrates proteins lipids etc Nitrogen

removal during treatment enhanced biological phosphate removal biological removal bio-

transformations and biosorption of metal ions aerobic and anaerobic degradation of xenobiotics

Unit-II

Activated sludge process

Single and two stage process special developments technological and microbiological aspects plant

configurations design

Unit-III

Modeling of aerobic waste water treatment process

Introduction purpose of modeling activated sludge model presentations waste water characteristics

various disinfection methods for waste water

Unit-IV

High rate anaerobic waste water treatment

Introduction basic principles reactor design parameters reactor operation

Unit-V

Biological Nutrient removal

Suspended growth and attached growth nutrient removal processes and design criteria ndash Nitrogen

(Nitrification and denitrification) and Phosphorus precipitation biological) Biological removal of

toxic and recalcitrant organic wastes

Unit-VI

Water reuse

Wastewater reclamation risk assessment various reclamation technologies storage agricultural

reuse industrial reuse groundwater recharge

Text book

1 Joumlrdening HJ and JWinter Environmental Biotechnology - Concepts and Applications

Cambridge University Press 2006

2 George Tchobanoglous and Franlin L Burton Wastewater Engineering- Treatment Disposal and

Reuse Tata McGraw Hill Publishing Co Ltd 1990

BT-722 6 Elective ndash Bioinformatics

Unit I

Introduction to Biological Databases Types Overview of Biological Databases and Retrieve

Nucleic acid databases NCBI PubMed Entrez Blast OMIM Books Taxonomy Structure

Locuslink Protein Databases- Primary Functional Composite Secondary Structural classification

database Sequence Formats amp storage Sequence submission to sequence Database

Unit II

Genomics Structure of DNA Polymorphisms in DNA Sequence Human Genome Project

Complete Genome Sequences Functional Annotation

Unit III

Human Genetic Variation Databases and Concepts Introduction Forms and mechanisms of

genetic variation Databases of human genetic variation SNP databases Mutation databases Genetic

marker and microsatellite databases Nonnuclear and somatic mutation databases Tools for SNP and

mutation visualization

Unit IV

Biological Sequence Analysis amp Characterization Predictive Functional Analysis of coding and

non-polymorphisms Amino Acid Properties and Consequences of Substitutions

Unit V

Genetics Genomics Interfaces Technologies for the measurement of gene expression The Cancer

Genome Anatomy Project (CGAP) The Human Transcriptome Map Protein Interaction Networks

Computational methods for pathways and systems biology databases and web resources

Unit VI

Soft computation Neural Networks and Machine learning support vector machines fuzzy logic

evolutionary computing genetic algorithms- applications to data mining and bioinformatics

Text Books

1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves Noah Hardy

ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd

2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS ISBN978-81-8318minus831minus9

Himalaya Publication House Discovering Genomics Proteomics and Bioinformatics Campbell

ISBN978813171 5598 Pearson Education

3 Proteomics Theory and Practice Gomase VS and Chikhale NJ Himalaya Publication House

4 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978- 3-527-30541-4

John Wiley amp Sons India Pte Ltd

5 Introduction to Bioinformatics Arthur M Lesk Oxford University Press 2003

6 Sequence and Genome Analysis by David W Mount - Cold Spring Harbor Laboratory 1st edition

2004

7 Bioinformatics A Practical Guide to the Analysis of Genes and Proteins by Andreas D

Baxevanis B F Francis Ouellette Wiley-Interscience 3rd Edition 2004

8 Sequence structure and Database ndash Des Higgins Willice Taylor Oxford press 1st edition (2003)

9 Fundamental Concepts of Bioinformatics - Dan E Krane Michael L Raymer Pearson education

First edition (2004)

BT-723 Self Study Open Area Seminar-II

BT-724 Minor Project- II

BT-725 Major Project- I

SEMESTER IV

BT-821 Major Project- II

Scheme of Examination and Syllabus

MTech in Industrial Biotechnology

Department of Biotechnology Delhi Technological University

Bawana Road New Delhi -110042

MTech in Industrial Biotechnology Biotechnology Industry Organization (BIO) USA has mentioned three major waves in the field of

biotechnology The first wave Green Biotechnology refers to agricultural biotechnology The

second wave Red Biotechnology refers to pharmaceutical and medical biotechnology while the third

wave White Biotechnology refers to industrial biotechnology Industrial biotechnology is mainly

based on biocatalysis (the use of enzymes and cells to catalyse chemical reactions) and fermentation

technology (directed use of micro-organisms) in combination with recent breakthroughs in the

forefront of molecular genetics and metabolic engineering It includes manufacturing of antibiotics

(cephalosporins streptomycin penicillin) food (yoghurt cheese single cell protein mushroom

probiotics) renewable energy (bioethanol biodiesel biohydrogen) health care (growth hormone

antibodies) biopolymers (polyhydroxy butyrate polylactic acid) enzymes (protease lipase amylase

cellulase pectinase xylanase) in various industries (pulp and paper detergent textile food

processing industry) Industrial biotechnology also involved in bioremediation microbial

degradation of pollutants (hydrocarbons polychlorinated biphenyl polyaromatic hydrocarbons)

Biological waste water treatment is undoubtedly one of the most important biotechnological

processes which have been used to treat municipal waste and industrial waste water The proposed

syllabus has been developed to address the need of well trained industrial biotechnologist cutting

edge RampD for this field The trained manpower will be well versed in techniques of protein science

bio-catalysis engineering biosynthesis microbial manufacturing engineering biological systems and

bio-process engineering Moreover they can easily implement these hands on training in industry to

increase the yield more accurately

Delhi Technological University Delhi

Department of Biotechnology

Scheme of Examination

MTech in Industrial Biotechnology

First semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-521 Bioenergy 3 1 0 50 100 150 3

BT-522 Food Engineering

amp Biotechnology

3 1 0 50 100 150 3

BT-523 Enzyme

Engineering amp

technology

3 1 0 50 100 150 3

BT-571 Industrial Plant

Biotechnology

3 1 0 50 100 150 3

BT-572 Bioinstrumentation 3 1 0 50 100 150 3

BT-573 Food engineering

and Biotechnology

Lab

0 0 2 30 70 100 2

BT-524 Bioinstrumentation

Lab

0 0 2 30 70 100 2

BT-574 Self Study open

area seminar-I

0 0 1 50 - 50 1

TOTAL 360 640 1000 20

Second semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-621 Biopharmaceuticals 3 1 0 50 100 150 3

BT-6221 Bioprocess

Engineering

3 1 0 50 100 150 3

BT-6231 Biosensor 3 1 0 50 100 150 3

BT-6711 Nanobiotechnology 3 1 0 50 100 150 3

BT-6721 Environmental

Biotechnology

3 1 0 50 100 150 3

BT-673 Environmental

Biotechnology Lab

0 0 2 30 70 100 2

BT-624 Bioprocess

Engineering Lab

0 0 2 30 70 100 2

BT-674 Minor Project-I 0 0 1 50 - 50 1

TOTAL 360 640 1000 20

Third semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-721 Professional

Elective I

3 1 0 50 100 150 3

BT-722 Professional

Elective II

3 1 0 50 100 150 3

BT-723 Self Study open

area seminar-II

0 0 1 100 100 2

BT-724 Minor Project-II 300 300 6

BT-725 Major Project-I 300 300 6

TOTAL 200 800 1000 20

Fourth semester

Course

Code

Subject L T P Internal

Marks

End Sem

Marks

Total

Marks

Credit

BT-821 Major Project-II 400 600 1000 20

TOTAL 1000 20

BT- 721 ELECTIVE SUBJECTS- I

BT-7211 Bioseparation Technology

BT-7212 Industrial waste water treatment

BT-7213 Biopolymer Technology

BT-7214 Bioprocess Plant Designing

BT-7215 Transport Phenomenon

BT-7216 Biochemical Thermodynamics

BT-722 ELECTIVE SUBJECTS- II

BT-7221 Bioethics Biosafety and IPR

BT-7222 Quality Management

BT-7223 Protein Engineering

BT-722 4 Metabolic Engineering

BT-7225 Design and Development of Biological Treatment process

BT-7226 Bioinformatics

SEMESTER I

BT- 521 Bioenergy

Unit-I

Introduction

Global energy scenario Indian energy scenario types of energy sources description of Biofuels

various Biofuels Bioenergy from biomass Biofuel Production Alternative Biochemical Pathways for

Organo-heterotrophic Lithotrophic and Phototrophic Metabolism Importance of biofuel feed stocks

Cellulose starch sugar Lignocellulosic Agro and Industrial by-products

Unit-II

Production of Bio-ethanol

Process Technology for Bioethanol production using Sugar Starch and Lignocellulosic Selection of

micro-organisms and raw materials Unit Operations in Alcohol production Continuous

fermentation Distillery quality control Alcohol distillation

Unit-III

Production of Biodiesel

Chemical Thermodynamic and Reaction Kinetic Aspects of Biodiesel Production Lipids as a source

of biodiesel Methods of Biodiesel Production ndash General procedure and large scale production

Quality Control Aspects Biodiesel production from microalgae and future prospects

Unit-IV

Production of Biohydrogen

Biohydrogen production by anaerobic bacteria and photosynthetic algae Enzymes involved in

biohydrogen Production Biochemical Pathway Batch Fermentation Factors affecting biohydrogen

production Carbon sources Process and Culture Parameters Detection and Quantification of

biohydrogen

Unit-V

Microbial Fuel Cells

Introduction and biochemical basis History of microbial fuel cell development Microbes used in

microbial fuel cells Design of microbial fuel cells MFC components Two and Single MFC systems

Stacked microbial fuel cell Performances of microbial fuel cells Ideal performance Actual MFC

performance Effects of operating conditions pH buffer and electrolyte Proton exchange system

Operating conditions in the anodic chamber Operating conditions in the cathodic chamber

Applications Electricity generation Biohydrogen Wastewater treatment Biosensor MFCs in the

future

Unit-VI

Case studies

Text books

1 Caye M Drapcho NP Nhuan and T H Walker Biofuels Engineering Process Technology Mc

Graw Hill Publishers New York 2008

2 Jonathan RM Biofuels ndash Methods and Protocols (Methods in Molecular Biology Series) Humana

Press New York 2009

3 Lisbeth Olsson (Ed) Biofuels (Advances in Biochemical EngineeringBiotechnology Series

Springer-Verlag Publishers Berlin 2007

BT- 522 Food Engineering and Biotechnology

Unit- I

Food chemistry

Food chemistry-definition and importance Composition of foods and function of water

carbohydrates proteins amino acids lipids vitamins and shelf life of food Bioavailability and

stability of nutrients Nutritive value of foods Food as a source of energy Food Health and diseases

Unit ndash II

Food Microbiology

History and significance of microorganisms in foods Biotechnological improvements catabolic

repression Microbial growth pattern Biochemical changes caused by micro-organisms deterioration

of various types of food product Food poisoning and microbial toxins standards for different foods

Food borne intcericants and mycotoxius

Unit ndashIII

Fermentation products

Dairy products Production of starter cultures Cheese - principles of cheese making Cheddar

Cheese Swiss Cheese Surface ripened Cheeses Mold ripened Cheeses General principles of

manufacture of Kefir Fermented foods Soy sauce Miso Sufu Natto Idli fermented fish products

Fermented vegetables Sauer Krant pickles Olives Fermented sausages Distilled beverages

Alcohol wine brandy and beer Food additives organic acid (acetic acid lactic acid and citric acid)

amino acids (glutamic acid lysine threonine arginine and histidine) food flavourants and pigments

Unit ndashIV

Food Preservation and storage

General principles underlying spoilage and chemical changes of food caused by microorganisms

(Staphylococcal Salmonellosis Ecoli) food spoiling enzymes Botulism toxin production and

deterioration of foods Principles of food preservation by physical methods (irradiation drying heat

processing chilling and freezing high pressure and modification of atmosphere) by chemical

methods and biological methods Storage Stability Food Preservation with Low Temperatures Food

Preservation with High Temperatures Preservation of Foods by Drying Indicator and Food-borne

Pathogens

Unit V

Food process technology

Packaging and canning of foods ndash preparation for packaging thermal processing of foods

Microwave heating thermal inactivation of microorganisms thermal process evaluations freezing

and thawing of foods Food process operations Evaporation single and multi effect evaporation

dehydration psychomatric charts drying-tunnel tray spray drum freeze distillation food

processing aid through biotechnology Food sanitation Good manufacturing practices ndash Hazard

analysis Critical control points Personnel hygiene

Unit ndashVI

Food Processing and Quality assurance

Basic principles unit operations and equipment involved in the commercially important food

processing methods and unit operations materials and containers used in food packaging Objectives

importance and functions of quality control Methods of quality assessment of food materials-fruits

vegetables cereals dairy products meat and poultry Food regulations grades and standards

Concept of Codex AlmentariousHACCPUSFDAISO 9000 series etc Food laws and standards

Text Books

1 Frazier WS and Weshoff DC Food Microbiology 4th Edn McGraw Hill Book Co New

York 1998

2 Mann amp Trusswell Essentials of human nutrition 3rd edition oxford university press 2007

3 Prescott and Dunns Gerald Reed Industrial Microbiology 4th Edition AVI Publishing Company

Inc Conneticut 1983

4 BSivashankar ndash Food processing and preservation Prentice ndash Hall of India PvtLtdNew Delhi

2002

BT- 523 Enzyme Engineering and Technology

Unit-I

Introduction to enzymes

Introduction nomenclature and classification of enzyme Mechanism and catalysis concept of active

site and energetics of enzyme substrate complex formation specificity of enzyme action principles

of catalysis ndash collision theory transition state theory role of entropy in catalysis Biocatalysis in

organic liquids Enzymatic catalysis in biphasic system Ribozyme Abzyme (catalytic antibodies)

Biosynthesis and regulation of enzyme in microorganism

Unit-II

Enzyme Kinetics

Kinetics of substrate and multisubstrate reactions King-Altmanrsquos method Analysis of kinetic data

Inhibition - substrate product and inhibitors Active and legend binding sites Allosteric regulation of

enzymes Monod changeux wyman model deactivation kinetics Molecular folding and defolding of

enzymes

Unit - III

Enzyme immobilization

Methods of immobilization External and internal diffusional mass transfer limitation Effectiveness

factor and modulus electrostatic and stearic effects in immobilized enzyme systems

Unit-IV

Enzyme Reactor

Reactors for Batch continuous enzymatic processing choice of reactor type idealized enzyme

reactor systems Mass transfer in enzyme reactors Steady state analysis of mass transfer and

biochemical reaction in enzyme reactors

Unit ndashV

Purification and Characterization of enzymes from natural source

Production and purification of crude enzyme extracts from plant animal and microbial sources

methods of characterization of enzymes

Unit-VI

Application of enzymes

Application of enzymes in different industries (Pulp and Paper industry Detergent industry Textile

industry Food processing industry) Medical and analytical application of enzyme Biosensor

Text books

1 Enzymes A Practical Introduction to Structure Mechanism and Data Analysis by RA Copeland

Publisher John Wiley and Sons Inc

2 Enzymes by Palmer (2001) Horwood Publishing Series

3 Introduction to Biocatalysis using Enzymes and Microorganisms by SM Roberts NJ Turner and

A J Willetts Publisher Cambridge University Press

4 Fundamentals of Enzymology by Price and Stevens (2002) Publisher Oxford University Press

5 Enzyme Technology by Helmut Uhling (1998) Publisher John Wiley

6 Introduction to Proteins Structure by Branden and Tooze (1998) Publisher Garland Publishing

7 Enzyme Kinetics Behavior and Analysis of Rapid Equilibrium and Steady - State Enzyme

Systems by IH Segel Publisher Wiley-Interscience

BT-571 Industrial Plant Biotechnology

Unit-I

Plant genome organization

Organization and features of mitochondrial nuclear and choloroplast genome ndash Structural features of

gene families in plants

Unit-II

Plant cell cultivation

Callus cultures cell cultures and protoplast cultures Micropropagation Organogenesis and somatic

embryogenesis Cell suspension culture Ovule culture Anther culture Production of haploids

Protoplast isolation and fusion Selection systems for somatic hybridscybrids Somaclonal variation

Preservation of germplasm Formation of Secondary Metabolites in Tissue Culture Production of

pharmaceuticals by tissue culture pigments perfumes flavors insecticides flavonoids

Biotransformation using plant cell cultures Bioreactor system and models for mass cultivation of

plant cells hairy root culture Quality assurance and quality control

Unit-III

Transgenic plant and application

Transgenesis in plants Gene transfer in plants ndash Gene transfer through vectors - Biology of vectors

used - Ti and Ri plasmids binary vectors viral vectors cloning strategy and method of gene transfer

Vectorless gene transfer ndash electroporation and gene gun method DNA bar coding Application of

transgenic plants Virus resistance coat protein mediated nucleocapsid gene Nematode resistance

Abiotic stress Drought cold and salt Post-harvest losses long shelf life of fruits and flowers use of

ACC synthase polygalacturanase ACC oxidase male sterile lines bar and barnase systems

carbohydrate composition and storage ADP glucose pyrophosphatase RNAi and Reverse genetics

Unit- IV

Natural Resource Management

Different approaches of Biodiversity Conservation Biotechnological Characterization and strategies

for the conservation of different populations of endangered plants Molecular markers and genetic

diversity screening

Unit-V

Plant metabolism Metabolomics and metabolic engineering

General concepts of metabolism Introduction to databases from plant transcriptomics to

metabolomics

Unit VI

Industrial applications

Industries engaged in tissue cultureplant cell suspension culture their working and management

Pharmaseutically useful metabolites generated by suspension cultures

Text books

1 Dixon RA and Gonzales Plant Cell Culture A Practical Approach IRL Press 1995

2 Lindsey K and MGK Jones Plant Biotechnology in Agriculture Prentice Hall New Jersey

1990

3 Biotol series In vitro Cultivation of Plant cell Butterworth Heinemann Ltd 1994

4 Ranga MM Animal Biotechnology (3e) Agrobios 2007

5 Bhojwani amp Rajdhan Animal and Plant Biotechnology Elsevier 1996 )

6 Gene cloning amp DNA Analysis An introduction by T A Brown Fourth edition (2001)

7 Genetic Engineering by S Rastogi and N Pathak Publishers Oxford University Press(2009)

8 Principles of Gene Manipulation amp Genomics by Primrose amp Twyman Seven edition (2006)

BT- 572 Bioinstrumentation

Unit I

Electrochemistry Temperature pH buffers Conductivity Dissolved oxygen carbon dioxide

Unit II

Centrifugation Basic principle and application Analytical and Preparative centrifuges and ultra

centrifugation

Unit III

Electrophoretic Techniques Paper and gel electrophoresis Immuno electrophoresis isoelectric

focussing two-dimensional electrophoresis capillary electrophoresis

Unit IV

Chromatographic Methods Paper TLC gas chromatography gel filtration ion exchange

chromatography affinity chromatography and HPLC FPLC

Unit V

Spectroscopy UVvisible and NIR spectrofluorimetry Atomic absorption spectrophotometryMass

Spectrometry Infrared and Raman SpectroscopyNuclear Magnetic Resonance and Electron Spin

Resonance spectroscopy

Unit VI

Microscopy Principle parts types and functioning of Microscope Optical and Electron

Microscopy Transmission and Scanning Electron Microscopy Tunneling Electron Microscopy

Atomic Force Microscopy Fluorescence microscopy Confocal microscopy

Text books

1 Principles and Techniques of Practical Biochemistry by Keith Wilson and JohnWalker Cambridge

University Press

2 Biophysical Chemistry The conformation of Biological Macromolecules by CRCantor and PR

Schimmel Publisher WH Freeman

Reference books

1 Essentials of Biophysics by P Narayanan Publishers New Age InternationalPublishers

2 Introduction to Spectroscopy by DL Pavia GM Lampman and G S Kriz Publisher Brooks

Cole

3 Physical Chemistry of Macromolecules by C Tanford Publisher John Wileyand Sons Inc

4 Principles of Physical Biochemistry by KE Van Holde Publisher Prentice Hall

BT-524 Lab- Bioinstrumentation 1 Measurement and control of pH 2 Measurement of conductivity of a given sample

3 Measurement of conductivity and dissolved oxygen in given sample

4 Protein quantification

5 Protein separation through electrophoresis

6 Sample preparation for light microscopy and Electron Microscopy

7 Quantification of DNA RNA Lipid Fatty acids

8 Sample analysis through AAS

9 Sample preparation for Fluorescence and Confocal microscopy

10 Isolation of DNA and analysis by gel electrophoresis

BT-573 Lab- Food Engineering and Biotechnology

1 Isolation of industrially important microbes

2 Production of fermented product

3 Comparative studies of ethanol production using different substrates

4 Production of wine

5 Production of citric acid

6 Detection of adulterants in food

7 Mushroom cultivation

8 Bread making

9 Colourant production

10 Studies of different methods of food preservation

11 Estimation of carbohydrates and proteins

BT-574 Self Study Open Area Seminar-I

SEMESTER II BT- 621 Biopharmaceuticals

Unit-I

Drug metabolism Oxidation reduction hydrolysis conjugation Need for developing new drugs

Procedure followed in drug design Molecular modification of lead compounds Prodrug and soft

drugs Physico-chemical parameters in drug design QSAR Active site determination of enzymes

Design of enzyme inhibitors

Unit-II

Pharmacokinetics and Drug discovery

Biotransformation of drugs Preclinical Pharmacokinetics Compartment modelingone compartment

open model two compartment open model multi compartment model non linear kinetics

bioavailability and bioequivalence excretion of drugs pharmacokinetics ndash effects of food and

fasting Substances derived from bacteria plants insects and animals Sources of active principles

Assay systems and models (eg Knock-out Mice) Protein molecular modeling by computer

Docking studies Structure based drug designing using software

Unit-III

Pharmaceutical dosage forms

Dosage Forms and Basic Preparations Excipients for Pharmaceutical Dosage Forms Compressed

tablets wet granulation dry granulation or slugging direct compression tablet formulation coating

capsules sustained action dosage form parental oral liquids ointments recombinant blood products

and therapeutic enzymes hormones of therapeutic interest Pharmaceutical products Analysis and

Control laxatives ndash analgesics ndash non steroidal contraceptives ndash external antiseptics ndash antacids and

other antibiotics ndash biological ndash hormones ndash vitamins - preservation analytical methods and test for

various drugs and pharmaceuticals packaging techniques ndash quality control

Unit-IV

Pharmaceutical products and products of DNA technology

Microbial products - Antibiotics (penicillin streptomycin tetracycline) vitamins probiotics Plant

secondary metabolites - control mechanism and manipulation of pheny-propanoid pathway and

shikimate pathway Tissue culture production of alkaloids flavanoids steroids terpenoids animal

vaccines Pharmaceutical products of DNA technology Therapeutic proteins ndash Insulin human

growth hormone clotting factors interferons interleukins tissue plasminogen activators

erythropoietin DNAseI alginate lyase muteins Production advantages limitations and applications

of monoclonal antibody Oligonucleotides and Gene therapy ras-Antisense therapy gene delivery

system Vector usage strategies for gene therapy Clinical trials

Unit-V

Drug safety evaluation

Strategy and Phasing for Drug Safety Evaluation in the Discovery and Development of

Pharmaceuticals Regulation of Human Pharmaceutical Safety Acute Toxicity Testing in Drug

Safety Evaluation Special Concerns for the Preclinical Evaluation of Biotechnology Products

Immunotoxicology in Pharmaceutical Development The Application of In Vitro Techniques in Drug

Safety Assessment Pharmaceutical Quality Assurance

Unit-VI

Patenting process in drug manufacturing process

Patenting- Patent types The patent application Patenting in biotechnology Preclinical trials Clinical

trials The role and remit of regulatory authorities-The Food and Drug Administration The

investigational new drug application The new drug application European regulations Guides to

good manufacturing practice Formulation and Delivery Issues of Therapeutic Proteins

Biotechnology-Derived Drug Products Formulation Development Stability Testing Filling and

Packaging

Text books

1 Heinrich Klefenz Industrial pharmaceutical biotechnology John Wiley sons 2002

2 Susanna Wu-Pong Yongyut Rojanasakul and Joseph Robinson Biopharmaceutical drug and

design and development Humana Press 2007

3 Gary Walsh Biopharmaceuticals Biochemistry and Biotechnology (2e) John Wiley amp Sons

2003

4 Herbert A Kirst Wu-Kuang Yeh Milton J Enzyme Technologies for pharmaceutical and

biotechnological applications WILEY-VCH Verlag 2003

BT- 6221 Bioprocess Engineering

Unit I

Media design and Sterilization kinetics

Criteria for good medium medium requirements for fermentation processes carbon nitrogen

minerals vitamins and other complex nutrients oxygen requirements medium formulation of

optimal growth and product formation examples of simple and complex media medium

optimization methods ndash Plackett and Burman and Response surface method Thermal death kinetics

of microorganisms batch and continuous heat sterilization of liquid media design of sterilization

equipment-batch and continuous ilter sterilization of liquid media air sterilization

Unit II

Metabolic stoichiometry and energetics

Stoichiometry of cell growth and product formation elemental balances degrees of reduction of

substrate and biomass available electron balances yield coefficients of biomass and product

formation maintenance coefficients energetic analysis of microbial growth and product formation

oxygen consumption ndash steps involved in the transfer of oxygen to broth and heat evolution in aerobic

cultures

Unit III

Growth and Production kinetics

Kinetic models for microbial growth Monod model growth of filamentous organisms product

formation kinetics - leudeking-piret models substrate and product inhibition on cell growth and

product formation Production kinetics Design for single and multiple reaction size comparisons of

single reactor for single reactions multiple reactor systems for single reaction reactions in parallel

in series and seriesparallel reactions of first order Heterogeneous reactions kinetics and mechanism

of heterogeneous non catalytic and catalytic reactions Non ideal flow - residence time distribution

studies CE F and I curves RTD in ideal reactors Models for Non ideal flow ndash zero ndash parameter

model One parameter model and two parameter model

Unit IV

Types and design of bioreactor

Construction material Basic components ndash Agitator aerator valves and steam traps seals stirrer

glands Stirred tank batch bioreactor stirred batch bio reactor for enzymes cell cultures Continuous

Stirred Tank Bioreactor Continuous operation of mixed reactor enzyme reactions in a mixed

reactor substrate inhibition kinetics and product inhibition kinetics chemostat with cell cultures ndash

steady state cell and substrate concentrations and productivity as a function of dilution rate CSTR

with immobilized enzymes operation of CSTR in a constant feed rate policy-simulation for

conversions with and without diffusion limitations chemostat in series Graphical design Plug Flow

and Packed Bed Bioreactor Performance equation with Michelin-Menten kinetics substrate

inhibition and product inhibition plug flow reactor for immobilized enzymes operation of plug flow

reactor in constant feed rate policy simulation for conversion with and without diffusion limitations

Fedndashbatch reactor Applications of fed reactor Fed batch operation of mixed reactor material

balance on cell and substrate Recycle system Chemostat with recycle Biological waste water

treatment Feed forward control of the activated sludge process The Transient Behavior of

Bioreactors Stability analysis Stability of the chemostat Stability of chemostat with substrate

inhibition Operating diagram Transient responses of the chemostat control of the chemostat

Turbidostat operation Nutristat operation

Unit V

Instrumentation and Control

Biochemical process variables and their measurements Control principles and their application in

bioreactors Theory of electrode processes and their applications Measurement and control of pH

temperature dissolved oxygen aeration and agitation redox potential foam etc On-line analysis of

process parameters Introduction to biosensors Transduction principles used in biosensors

Characteristics of biosensors Biosensors based on amperometric potentiometric thermistor FET

fiber optics and bioluminescence Microbial biosensors Fundamentals of digital process control Use

of computer in control and optimization of microbiological processes

Unit VI

Downstream processing

Removal of microbial cells and solid matter foam separation precipitation filtration centrifugation

cell disruptions liquid-liquid extraction chromatography membrane process drying and

crystallization Quality analysis and product formulation - Product appearance product stabilization

shelf life analysis usage specific formulations quality analysis and control

Text books

1 Biochemical Engineering Fundamentals by JE Baily and DF Ollis Publisher McGraw Hill

(1986)

2 Biochemical Engineering by SAiba AE Humphry and NF Millis Publisher University of

Tokyo press(1973)

3 Bioreaction engineering principles by J Nielson and J Villadsen Publisher Plenum Press (1994)

4 Chemical Engineering Design Fourth edition by JM Coulson and JF Richardson Publisher

Butterworth Heinemann(2005)

5 Bioprocess Engineering- Kinetics Mass transport reactors and gene expression by WR Veith

Publisher John Wiley and Sons Inc(1994)

6Bioprocess Engineering Basic Concepts by ML Shuler and F Kargi Publisher Prentice Hall

(1987)

7Bioprocess engineering principles by P Doran Publisher- Academic press (1995)

BT-6231 Biosensor Unit-I

Introduction

A historical perspective Definition and Expanding Needs of Biosensors Advantages and limitations

Biosensor Economics various components of biosensors

Unit-II

Types of Biosensors

Biocatalysts based biosensors bio affinity based biosensors amp microorganisms based

biosensors biologically active material and analyte Types of membranes used in

biosensor constructions

Unit-III

Transducers in Biosensors

Various types of transducers principles and applications Bio- chemi- and lectrochemiluminescence

for fiber-optic biosensors Fluorescence-based fiber-optic biosensors

Unit-IV

Electrical Signal Detection in Biological Systems

Silicon glass and metal electrodes amplifier design Bioelectronic device production

microelectronic fabrication methods as adapted to bioelectronics hard and soft lithography bio-

compatibility of materials Existing types of Biosensors Miniaturisation and micro-systems

including sensing using optical techniques field effect transistors ion-selective and enzymatic

sensitive electrodes as well as impedance monitoring

Unit-V

Kinetic modeling for biosensors

The purpose and practice of modeling The flux equations The flux diagram for the membrane

enzyme electrode Deriving a complete kinetic model Kinetic modeling in other types of

biosensors- Potentiometric enzyme electrodes Optical and photometric biosensors Immunosensors

Unit-VI

Application and Uses of Biosensors

Biosensors in medicine and health care (For glucose monitoring and for DNA analysis Analysis of

the neural cell impulse signal and neural signal processing) biosensors for agriculture and food Low

cost- biosensor for industrial processes for online monitoring biosensors for environmental

monitoring

Text books

1 Rajmohan Joshi Biosensors (1e) Gyan Books 2006

2 Cooper JM and Anthony EG Biosensors (2e) Oxford University Press 2004

3 Turner APF KarubeI and WilsonGS Biosensors Fundamentals and applications Oxford Univ

Press 1990

4 SadanaA Biosensors Kinetics of Binding and Dissociation Using Fractals (1e) Elsevier BV

1995

5 Ashok M and Kim Rogers Enzyme amp Microbial Biosensors Techniques and Protocols (Methods

in Biotechnology) (1e) Humana Press 1998

6 Ashok M and Kim Rogers Affinity Biosensors Techniques and Protocols (Methods in

Biotechnology) (1e) Humana Press 1998

7 Damia Barcelo Biosensors for the Environmental Monitoring of Aquatic Systems Bioanalytical

and Chemical Methods for Endocrine Disruptors (1e) Springer 2009

BT-6711 Nanobiotechnology

Unit-I

Introduction

Nano - definition The fundamental Science behind nanotechnology- electrons atomsand ions

molecules metals biosystems Synthesis and Characterizations of Nanoscale Materials Strategies for

Nano architecture (top down and bottom up approaches) Fabrication Technologies and

Characterizations Self-assembly Systems Basic aspects of Nanofluidics surfactants polymers

emulsions and colloids Nanoscale Artificial Platforms Lipids in Self-assembly Structures

Nanoparticle synthesis in plants bacteria and yeast and its applications

Unit-II

Nano-structured materials

Fullerenes - Properties and CharacteristicsCarbon Nanotubes - Characteristics and Applications

Quantum Dots and WiresGold Nanoparticles Nanopores carbon nanotubes Applications of

NanoMolecules in Biosystems

Unit-III

Structural and functional principles of nanobiotechnology

Structural principle Factors governing biomolecular structure and stability Protein folding Self

assembly Self-organization Molecular recognition and Flexibility of biomaterials Functional

principles of Bionanotechnology Information driven nanoassembly Energetics Role of enzymes in

chemical transformation allosteric motion and covalent modification in protein activity regulation

Structure and functional properties of Biomaterials Bimolecular motors ATP Synthetase and

flagellar motors Traffic across membranes Potassium channels ABC Transporters and

Bactreriorhodapsin Bimolecular sensing Self replication Machine-Phase Bionanotechnology

Unit-IV

Bionanomachines and their Basic

Negligible gravity and inertia atomic granularity thermal motion water environment and their

importance in bionanomachines The role of proteins amino acids nucleic acids lipids and

polysaccharides in modern biomaterials Overview of natural Bionanomachines Thymidylate

Sythetase ATP synthetase Actin and myosin Opsin Antibodies and Collagen

Unit-V

Biophotonics and Bioimaging

Overview of imaging biological systems from the cellular level through to wholebody medical

imaging Introduction to biophysics basic physical concepts in imaging Major techniques using

ionizing and non-ionizing radiation fluorescence and multi-photon microscopy spectroscopy OCT

MRI X-ray CT PET and SPECT imaging

Unit-VI

Application of Nanobiotechnology

Nano-biotechnology in drug Delivery Nanoscale Devices for Drug Discovery Micelles for Drug

Delivery Protein targeting Small Molecule-Protein Interactions Micro-array and Genome Chips

Nanotechnology and the Cell Cell Motility Nano Motors and Cellular Navigation hemotaxis -

Transmembrane Signalling and Related Protein Nanotechnology for Cancer Diagnostics and

Treatment Nanotechnology for Cancer Research and Therapy siRNA Tumor-targeted Drug

Delivery Systems Nanotechnology for Imaging and Detection

Text Books

1 NANO by TPradeep 2006Tata Mc Graw Publishers India

2 Nanobiotechnology Concepts Applications and Perspectives Christof MNiemeyer Chad

AMirkin (eds) Wiley-VCH Weinheim (2004)

3 Kamali Kannangara Geoff Smith Michelle Simmons Burkhard Raguse

4 Overseas Press (2005)

5 David S Goodsell Bionanotechnology John Wiley amp Sons 2004

6 Greco Ralph S Nanoscale Technology in Biological Systems CRC Press 2005

BT-6721 Environmental Biotechnology

Unit-I

Basic concepts of ecology Interaction between environment and biota Concept of habitat and

ecological niches Limiting factor Energy flow food chain food web and trophic level NPC and S

cycles in nature Ecosystem dynamics and management Environmental impact assessment

Principles of conservation Conservation strategies sustainable development Global environmental

problems ozone depletion UV-B radiation green house effect and acid rain their impact in

biotechnological approaches for management

Unit-II

Environmental pollution

Types of pollution and pollution analysis ndash noise air and gaseous pollution Noise pollution Source

measurement impact on ecosystem and control Air pollution Types source method of sampling

measurement impact on ecosystem and control Control of noise and air pollution by

biotechnological methods Gaseous pollutants and odours General sources methods of control

fundamentals of adsorption mechanism of adsorption equilibrium isotherms break through curve

adsorption equipment regeneration of adsorbent application of adsorption for control of gaseous

and odour emission

Unit-III

Water pollution Impurities in water water pollution by industrial waste examination of water

collection of water samples water analysis ndash physical chemical and biological Standards of water

quality Water treatment processes Primary treatment screening skimming with coagulants

flocculation filteration aeration and disinfection Secondary treatment Aerobic processes ndash

activated sludge oxidation ditches recirculating system trickling filter towers rotating discs

rotating drums oxidation ponds Anaerobic digestion anaerobic filters Up flow anaerobic sludge

blanket reactors Tertiary treatment Activated carbon treatment reverse osmosis and electro dialysis

Unit-IV

Bioremediation

In situ and ex situ bioremediation technologies for various pollutants and sites bioremediation of oil

spills and heavy metal pollution use of microbes in bioremediation hydroponic system pollution

control boards and pollution control acts

Unit-V

Solid waste management sewage sludge treatment and utilization refuse disposal excreta disposal

in unsewered area composting and vermiculture biodegradation of noncellulosic wastes for

environmental conservation and fuel bioconversion of cellulosic wastes into protein and fuel

bioremediation of contaminated soils and waste lands radioactive product waste disposal

Unit-VI

Effluent treatment Sources of pollution impact on ecosystem and treatment of following industrial

effluents starch paper and pulp tannery dairy distillery oil refineries and pharmaceutical

Microbes in mining ore leaching oil recovery biopolymers biosurfactants

Text Books

1 Bruce E Rittmann and perry L Mccarty ldquoEnvironmental Biotechnology Principle and

Applicationsrdquo McGraw Hill publishing company Ltd2001

2 Mecalf and Eddy Inc ldquoWastewater Engineering Treatment Disposal Reuserdquo McGraHill

publishing company Ltd1991

3 Des W Connell ldquoBasic concepts of Environmental chemistryrdquo Lewis publishers2005

4 Michal J PelczarECS ChanNoel RKriegTata McGraw Hill publishing company Ltd1993

5 Alan Scragg Environmental BiotechnologyOxford University press2005

6 Prescott Harley Klein Microbiology WCB publishers1996

7 Richard T Wright and Bernard J Nebel ldquoEnvironmental Science towards a Sustainable Futurerdquo

Prentice Hall of India 2004

BT-624-Bioprocess Engineering Lab

1 To determine the concentration of protein content by Lowry method

2 To determine the concentration of sugar by 3 5 dinitrosalicylic acid method

3 To determine the optimum pH for given enzyme sample

4 To determine the optimum temperature for given enzyme sample

5 To study the immobilization of invertase enzyme

6 Measurement of citric acid production by Aspergillus niger with TLC

7 Determination of thermal death point (TDP) of the given microorganism

8 Production of ethanol from yeast fermentation of sugars

9 To prepare the growth curve of micro-organism cultured in a shake flask

10 To study the kinetics of lipase enzyme

BT-673- Environmental Biotechnology Lab 1 Environmental Impact Assessment Measurement of Air and Noise Pollution

2 Analysis of water temperature and pH

3 Measurement of Conductivity and TDS in water

4 Measurement of Dissolved Oxygen

5 Measurement of Carbondi Oxide and Hardness of water

6 Measurement and analysis of Ammonia and Ammonium in water

7 Measurement of Nitrite Nitrate and Total Nitrogen in water

8 Biochemical Oxygen Demand and Chemical Oxygen Demand measurements and analysis

9 Analysis of any one industrial effluent

10 Production of methane from sewage sludge

11 Vermicomposting

BT-674 Minor Project- I

SEMESTER III

BT-721 1 Elective ndash Bioseparation Technology Unit- I

Role of Downstream Processing in Biotechnology

Role and importance of downstream processing in biotechnological processes Problems and

requirements of bioproduct purification Economics and downstream processing in Biotechnology

Cost cutting strategies characterstics of biological mixtures process design criteria for various

classes of bioproducts (high volume-low value products and low volume- high value products)

physicochemical basis of bioseparation processes

Unit- II

Primary Separation and Recovery Processes

Cell disruption methods for intracellular products removal of insolubles biomass (and particulate

debris) separation techniques flocculation and sedimentation centrifugation and filtration methods

Precipitation methodsPrecipitation with salts organic solvents amp polymers

Unit- III

Extraction

Batch extractions staged extractions-cross current co current counter current extractions

Differential extractions fractional extractions with a stationary phase fractional extractions with two

moving phases Aqueous two-phase extraction reverse micelle extraction supercritical fluid

extraction in-situ product removalintegrated bioprocessing

Unit- IV

Membrane-based separations (micro- and ultra-filtration)

Theory design amp configuration of membrane separation equipment applications

reverse osmosis dialysis electro dialysis Isoelectric focusing

Unit- V

Adsorption

Adsorption isotherms industrial adsorbents adsorption equipments for batch and continuous

operations (co current and counter current) adsorption in fixed beds

Unit- VI

Chromatography

Principles of chromatographic separation ndash gel filtration reversed phase hydrophobic interaction

ion-exchange expanded bed adsorption bio affinity and IMAC supercritical fluid chromatography

Text books

1 Belter PA Cussler E and Wei Shan Hu Bioseparation ndash Downstream Processing for

Biotechnology Wiley Interscience 1988

2 Asenjo and Juan A Asenjo Separation Processes in Biotechnology CRC Press 1990

3 Wankat PC Rate Controlled Separation Kluwer Publishers 1990

4 Wang DIC Cooney CL Demain AL DunnilP Humphery AE and Lilly MD Fermentation

and Enzyme Technology John Wiley and Sons 1979

BT-721 2 Elective - Industrial Waste water treatment

UNIT I

Waste disposal management Methods of waste disposal industrial waste (solid liquid and gaseous

emission) effect of industrial wastes on streams and sewerage systems Treatment system of waste

disposal eg Incenerator differences in waste quality and quantity physico-chemical and biological

treatments of waste and their evaluation in respect of treatment

UNIT II

Characteristic features of wastes (solid liquid and gaseous emission) manufacturing processes and

toxic byproducts generated from iron ore alumina heavy metals units paper and pulp industries

pesticides industry thermal power station distillery textile and crude oil industry

UNIT III

Small and large scale industries for waste reduction and remediation various methods for waste

alteration volume and strength minimization recycling plants material restoration and conservation

Methods for neutralisation equalization precipitation and solidification for waste handling

Economic sustainability and government support for joint treatment of raw effluent municipal

sewage and debris

UNIT IV

Unit operations and their design for treatment and management of wastes (solid liquid and gaseous)

UNIT V

Landfill design and operation including site selection engineered sites liners and covers leachate

control and treatment gas recovery and control including utilization of recovered gas (energy) and

landfill monitoring and reclamation

UNIT VI

Case studies

Text Books

1 S P Mahajan ldquoPollution Control in Process Industriesrdquo Tata Mc Graw Hill Publications

2 W Wesley Eckenfelder Jrrdquo Industrial Water Pollution Controlrdquo Mc Graw Hill Publications

3 Ronald W Crites Sherwood C Reed and Robert Bastion ldquoLand Treatment Systems for Municipal

amp Industrial Wastesrdquo Mc Graw Hill Publications

4 Neal K Ostler ldquoIndustrial Waste Stream Generationrdquo Prentice Hall

5 Rao and Dutta ldquoIndustrial waste treatmentrdquo Oxford and IBH Publishing Co Pvt Ltd New Delhi

6 Dr A D Patwardhan ldquoindustrial Waste Water Treatmentrdquo Prentice Hall of India

BT-721 3 Elective-Biopolymer Technology Unit-I

Introduction

Biopolymers ndash The current scenario different biopolymers ndash produced from various renewable

resources characteristics merits and demerits over conventional polymers

Unit-II

Biopolymer Technology and Applications

Biopolymers and Artificial Biopolymers in Biomedical Applications an Overview Novel Synthesis

of Biopolymers and Their Medical Applications Composite Films Based on Poly (Vinylalcohol) and

Lignocellulosic Fibres Preparation and Characterizations Composite Materials Based on Gelatin

and Fillers from Renewable Resources Thermal and Mechanical Properties Properties of PHAs and

Their Correlation to Fermentation Conditions

Unit-III

Biosynthesis and Modifications

Synthesis and modification of different Biopolymers like xanthum gum

Unit-IV

Biosurfactants

Source characteristics and properties of Biosurfactants Production of Biosurfactants via the

fermentation and biotransformation routes Production of Biosurfactants with immobilized cells

Integrated bioprocess for continuous production of Biosurfactants including downstream processing

Applications of Biosurfactants-Food Industry Environmental Control

Unit-V

Bioplastic

Different types of bioplastics Starch-based plastic Cellulose-based plastic Aliphatic polyesters

Poly-3-hydroxybutyrate (PHB) Polylactic acid (PLA) Polyamide Bio-derived polyethylene

Advantages of bioplastic over petroleum-based polymer Mechanism of synthesis of Poly (-

hydroxybutyric acid) (PHB)

Unit-VI

Material Testing and Analytical Methods

An Overview of Available Testing Methods Comparison of Test Systems for the Examination of the

Fermentability of Biodegradable Materials Structure- Biodegradability Relationship of biopolymers

Text Books

1 Emo Chiellini Emo Chiellini and Helena Gil Biorelated Polymers Sustainable Polymer Science

and Technology Springer 2001

2 Johnson RM LY Mwaikambo and N Tucker Biopolymers Rapra Technology 2003

3 Naim Kosaric (Ed) Biosurfactants Marcell Dekker Inc 1993

BT-721 4 Elective ndash Bioprocess Plant Designing Unit-I

Process development

Introduction to Design ndash nature of design ndash Technical feasibility survey Mass and energy balance

process development ndash data acquisition ndash design data information of project - Organization of project

ndash Project documentation ndash codes and standards

Unit-II

Design Development

Equipment selection and specifications-materials of construction ndash flow sheeting - piping and

instrumentation ndash process safety and loss prevention

Unit-III

General site consideration

Introduction ndash plant location and site selection ndash site layout- plant layout utilities ndash environmental

considerationsndash waste management ndash visual impact ndash government regulations and other legal

restrictions community factors and other factors affecting investment and production costs ndash human

resources

Unit ndashIV

Selection and specification

Selection and specification of equipment for handling fluids and solids Selection specification

design of heat and mass transfer equipment used in bioprocess industries Design of facilities for

cleaning of process equipment used in biochemical industries Utilities for biotechnology

Unit-V

Design of fermenters

Design of fermentation Design considerations for maintaining sterility of processing equipment

Unit-VI

Process economics

Production plants Bioprocess validation Safety considerations

Text books

1 Applied Process Design for Chemical and Petrochemical Plants by EE Ludwig Publisher

Butterworth-Heinemann

2 Chemical Engineering by RK Sinnott JM Coulson and JF Richardsons Publisher

Butterworth-Heinemann Vol-6 Butterworth Heinemann III editionndash 2002

3 Peters and Timmerhaus Plant Design and Economics for Chemical Engineers Mcgraw Hill

4thEdition 1989

4 Rudd and Watson Strategy of Process Engineering Wiley 1987

BT-721 5 Elective- Transport Phenomenon Unit -I

Diffusion

Molecular and turbulent diffusion Diffusion coefficient Flickrsquos Law of diffusion Dependence of

diffusion coefficient on temperature pressure and composition Diffusion in multi-component gas

mixtures Diffusion in solids Molecular Knudsen ampsurface diffusion Inter- phase mass transfer

Mass transfer coefficients Diffusion between phases Equilibrium solubility of gases in liquids

Mass Transfer theories Mass transfer in fluidized beds flow past solids and boundary layers

Simultaneous heat and mass transfer Mixing in a Bioreactor -Flow regimes with and without baffles

various types of impellers and mixing equipment Power Requirements for Mixing Ungassed

Newtonian Fluids Gassed Fluids Improving Mixing in Fermenters Effect of Rheological Properties

on Mixing Role of Shear in Stirred Fermenters

Unit-II

Drying and Crystallization

Solid-gas equilibria Different modes of drying operation Types of batch and continuous dryer

Definitions of moisture contents Rate of batch drying Time of drying Mechanism of batch drying

Continuous drying Equilibrium yield of crystallization Heat and mass transfer rates in

crystallization Theories of crystallization Factors governing nucleation and crystal growth rates

controlled growth of crystal Classification of crystallizers

Unit ndashIII

Absorption and Adsorption

Gas-Liquid equilibriaHenryrsquos Law Selection of solvents Absorption in tray column Graphical and

analytical methods Absorption in packed column Design equation for packed column HTU NTU

and HTEP concepts Equipments Description of adsorption process and their application Types of

adsorption Nature of adsorbents Adsorption equilibrium and adsorption hysterises Stage wise and

continuous contact adsorption operation operations Determination of number of stages Equipments

Unit-IV

Momentum transfer

Review of basic concepts ndash Conservation of Mass Conservation of Energy Momentum Balance ndash

Momentum Balance in a Circular Pipe Flow Velocity Profile Fermentation Broth Rheology ndash

Viscosity Rheological Properties of Fermentation Broths Factors affecting broth viscosity

Unit V

Conduction and Convection

Introduction Conduction Basic concepts of conduction in solids liquids and gases One and two

dimensional heat conduction Critical and optimum insulation thickness Introduction to unsteady

state heat transfer Principles of convection Equations of forced and free convection

Unit ndashVI

Radiation

Basic laws of heat transfer by radiation black body and gray body concepts solar radiations

combined heat transfer coefficients by convection and radiation Introduction of Heat Transfer

Equipments Heat Exchangers Evaporators Condenser

Text Books

1 Holman JP ldquoHeat Transferrdquo 9 th ed McGraw Hill (1989)

2 Treybal R ldquoMass Transfer Operationsrdquo 3rd ed New York McGraw-Hill (1980)

3 McCabe Smith Unit Operations in Chemical Engineering McGraw Hill

4 Foust A S etal ldquoPrinciples of Unit Operationsrdquo John Wiley (1980)

5 R B Bird et al Transport Phenomena 2nd Edition Wiley(2006)

BT-721 6 Elective ndash Biochemical thermodynamics Unit-I

Fundamental concepts of Thermodynamics

System and Surroundings First law of thermodynamics -Internal energy enthalpy Heat capacity

applied examples from biochemistry Second law ndash Entropy and universe Concept of heat engines

protein stability and calorimetric measurements Fundamentals of Differential scanning calorimeter

and Isothermal calorimeter in biological property measurements Third law of thermodynamics

Maxwell equations Gibbs-Duhem Equation and the Phase Rule Legendre Transforms

Unit-II

Non-equilibrium Thermodynamics

Reversible work exact differentials and function of state first and second law The electrochemical

potential External forces and steady state Fickrsquos Law chemical reactions in the steady state internal

entropy production cells as non-equilibrium stationary states Diffusion and membrane transport

Biological Systems as Open Non-equilibrium Systems Failure of classical thermodynamics in

describing biological processes Standard free energy changes and equilibrium constants direction

and rate

Unit-III

Bioenergetics

Energetics of metabolic pathways ndash energy coupling (ATP amp NADH) stoichiometry ndashenergetic

analysis of cell growth and product formation ndash elemental balances Degree ofreduction concepts

available- electron balances yield coefficients oxygen consumptionand heat evolution in aerobic

cultures thermodynamic efficiency of growth Thermodynamics of Biological Systems

Thermodynamic analysis of oxidative photophosphorylation stability of non-equilibrium stationary

states ordering in time and space far from equilibrium glycolytic oscillations Biological clocks

routes to chaos

Unit-IV

Chemical Potential

Visualization of the potential Steady velocity and steady flow Fickrsquos law and diffusion Local

Equilibria and Steady State Energy vs Power Transducers in biological states Constitutive

equations Dynamic efficiency and Onsager (nonequilibrium thermodynamics) Prigoginersquos principle

Spontaneous coupling and entropy production

Unit-V

Gibbs free energy and its Applications

Gibbs free energy and equilibrium Chemical potential ionic solutions Equilibrium constant

standard state in biochemistry Acid and bases chemical coupling and redox reactions Gibbs free

energy in photosynthesis glycolysis citric acid cycle Oxidative phosphorylation and ATP

hydrolysis substrate cycling Membrane transport Enzyme substrate interaction Haemoglobin

Protien solubility stability and dynamics

Unit-VI

Reaction Kinetics

Rate of a reaction rate constant and order of the reaction effect of temperature collision and

transition state theory Electron transfer kinetics Enzyme kinetics and inhibition Reaction

mechanism of lysozyme protein folding and pathological misfolding polymerisation muscle

contraction and the molecular motors

Text Books

1 Smith JM Van Ness HC Abbot MM Chemical Engineering Thermodynamics 6th Edition

McGraw-Hill 2001

2 Narayanan KV A Text Book Of Chemical Engineering Thermodynamics Prentice Hall India

2001

3 Sandler SI Chemical And Engineering Thermodynamics John Wiley1989

4 Bailey amp Ollis Biochemical Engineering Fundamentals II edition Megraw Hil ndash 1986

5 Donald T Haynie Biological Thermodynamics Cambridge press 2008

6 Robert A Alberty Thermodynamics of Biochemical Reactions John willy publications 2003

7 Bioenergetics by AL Lehninger Publisher WA Benjamin Inc

8 Biological Thermodynamics by DT Haynie Publisher Cambridge University Press

9 Biophysical Chemistry by CR Cantor and PR Schimmel Publisher

10 FreemanThermodynamics and Kinetics for the Biological Sciences by GG Hammes Publisher

John Wiley and Sons Inc

BT-7221 Elective - Bioethics Biosafety and IPR Unit I

Introduction to ethics and bioethics

Personal ethics profession and professionalism -Moral Reasoning -Ethical theories - person as an

experimenter -Moral leadership (integrity and ingenuinity) ndash framework for ethical decision making

Biotechnology and ethics Biotechnology in agriculture and environment benefits and risks ndash

benefits and risks of genetic engineering ndash ethical aspects of genetic testing ndash ethical aspects relating

to use of genetic information ndash genetic engineering and biowarfare

Unit-II

Ethical implications of cloning

Reproductive cloning therapeutic cloning Ethical legal and socio-economic aspects of gene

therapy germ line somatic embryonic and adult stem cell research- GM crops and GMO‟s ndash

biotechnology and biopiracy ndash ELSI of human genome project

Unit-III

Introduction to biosafety

Biosafety issues in biotechnology ndash risk assessment and risk management ndash safety protocols risk

groups ndash biosafety levels ndash biosafety guidelines and regulations (National and International) ndash

operation of biosafety guidelines and regulations ndash types of biosafety containment International

guidelines with regard to rDNA technology transgenic science GM crops etc Experimental

protocol approvals levels of containment Guidelines for research in transgenic plants Good

manufacturing practice and Good lab practice (GMO and GLP)

Unit-IV

Introduction to intellectual property and intellectual property rights

Types patents copy rights trade marks design rights geographical indications ndash importance of IPR

ndash patentable and non patentables ndash patenting life ndash legal protection of biotechnological inventions ndash

world intellectual property rights organization (WIPO) Plant breederrsquos rights Legal implications

Biodiversity and farmers rights Examples of patents in biotechnology Special application of patent

laws in biotechnology Licensing and cross licensing Flavr SavrTm- Tomato as model case and case

studies

Unit-V

Public acceptance issues for biotechnology

Environmental aspects of biotech application Use of genetically modified organisms and their

release in environment Case studies or experiences from developing and developed countries

Biotechnology and hunger Challenges for the Indian Biotechnological research and industries

Unit-VI

Socioeconomic impacts of biotechnology

The legal and socioeconomic impacts of biotechnology public education of the processes of

biotechnology involved in generating new forms of life for informed decision making

Text Books

1 Ethics in engineering Martin MW and SchinzingerR III Edition Tata McGraw- Hill New

Delhi 2003

2 Biotechnologies and Development UNESCO Publications 1988

3 A Biotechnologies in developing countries present and future UNESCO Publishers 1993

4 Singh K Intellectual property rights on Biotechnology BCIL New Delhi

BT-722 4 Elective ndash Metabolic Engineering Unit ndash I

Cellular metabolism

An overview of cellular metabolism-transport processes- Fueling reactions -glycolysis-fermentative

pathways-TCA cycle and oxidative phosphorylation-anaplerotic pathways -catabolism of fats

organic acids and amino acids -biosynthetic reactions of amino acids ndash nucleic acids fatty acids and

other building blocks -polymerization - growth energetics

Unit ndash II

Comprehensive models for cellular reactions

Stoichiometry of cellular reactions -reaction rates-dynamic mass balances-Yield coefficients and

linear rate equation Material Balance and data consistency ndashblack box model elemental balance -

heat balance -analysis of over determined systems - identification of gross measurement errors

Unit ndash III

Regulation of metabolic pathways

Overview of enzyme kinetics ndash simple reversible inhibition systems ndash irreversible inhibition ndash

allosteric enzymes cooperativity ndash regulation of enzyme concentration ndash transcription initiation ndash

translation regulation at whole cell level ndash regulation of metabolic networks enhancements of

product yield and productivity for ethanol and amino acids pathways metabolic pathway

manipulations to extend substrate range product spectrum and novel products improvement of

cellular properties

Unit ndash IV

Metabolic flux analysis

Theory ndash overdetermined systems ndash underdetermined systems ndash sensitivity analysis ndash methods for the

experimental determination of metabolic fluxes by isotope labeling direct flux determination from

fractional enrichment ndash applications involving complete enumeration of metabolite isotopomers ndash

carbon metabolite balances Applications of metabolic flux analysis ndash amino acid production by

Glutamic acid Bacteria

Unit ndash V

Metabolic control analysis

Fundamentals of Metabolic control analysis -determination of flux control coefficients ndash MCA of

Linear pathways ndash branched pathways ndash theory of large deviation

Unit-VI

Applications of metabolic engineering

Text Books

1 Gregory N Stepanopoulos Aristos A Aristidou Jens Nielsen Metabolic Engineeing

2 Principles and methodologies Academic Press 1998

3 Wang DIC Cooney CL Demain AL DunnilP Humphery AE Lilly MD

4 ldquoFermentation And Enzyme Technologyrdquo John Wiley And Sons 1980

5 Zubay G ldquoBiochemistryrdquo Macmillan Publishers 1989

BT-722 3 Elective ndash Protein Engineering Unit-I

Bonds and Energies in protein

Covalent Ionic Hydrogen Coordinate hydrophobic and Vander walls interactions in protein

structure Interaction with electromagnetic radiation (radio micro infrared visible ultraviolet X-

ray) and elucidation of protein structure

Unit-II

Amino acids and their characteristics

Amino acids ndash structure with three and single letter codes- molecular properties (size solubility

charge pKa) Chemical reactivity in relation to post-translational modification (involving amino

carboxyl hydroxyl thiol imidazole groups) and peptide synthesis

Unit - III

Protein architecture

Primary structure peptide mapping peptide sequencing - automated Edman method amp massspec

High-throughput protein sequencing setup Secondary structure Alpha beta and loop structures and

methods to determine Super-secondary structure Aphaturn- alpha beta-turn-beta (hairpin) beta-

sheets alpha-beta-alpha topology diagrams up and down amp TIM barrel structures nucleotide

binding folds prediction of substrate binding sites Tertiary structure Domains folding denaturation

and renaturation overview of methods todetermine 3D structures Quaternary structure Modular

nature formation of complexes

Unit-IV

Structure-function relationship

DNA-binding proteins prokaryotic transcription factors Helix-turn-Helix motif in DNA binding

Trp repressor Eucaryotic transcription factors Zn fingers helix-turn helix motifs in homeodomain

Leucine zippers Membrane proteins and receptors bacteriorhodopsin and Photosynthetic reaction

center Immunoglobulins IgG Light chain and heavy chain architecture abzymes and Enzymes

Serine proteases understanding catalytic design by engineering trypsin chymotrypsin and elastase

substrate-assisted catalysis other commercial applications

Unit -V

Identification and analysis of proteins

Identification and analysis of proteins by 2D analysis Spot visualization and picking Tryptic

digestion of protein and peptide fingerprinting Mass spectrometry ion source (MALDI spray

sources) analyzer (ToF quadrupole quadrupole ion trap) and detector

Unit-VI

Tools in proteomics and genomics

Site directed mutagenesis for specific protein function Basic concept for designing a new

proteinenzyme molecule Specific examples of enzyme engineering Tryesyl t RNA synthetase

Dihydrofolate reductase Subtilisin Advantages ndash protein data base analysis ndash methods to alter

primary structure of proteins examples of engineered proteins thermal stability of T4-lysozyme

recombinant insulin to reduce aggregation and inactivation de novo protein design ndash principles and

examples

Text Books

1 Voet D and Voet G Biochemistry Third edn John Wiley and Sons 2001

2 Moody PCE and Wilkinson AJ Protein Engineering IRL Press Oxford UK 1990

3 Branden C and Tooze J Introduction to Protein Structured Second Edition GarlandPublishing

NY USA 1999

4 Creighton TE Proteins Freeman WH Second Edition 1993

BT-7222 Elective ndash Quality Management Unit-I

Quality Concepts

Definition of Quality Dimensions of Quality Quality Planning Quality costs ndash Analysis

Techniques for Quality Costs Evolution of Quality Control Basic concepts of Total Quality

Management Historical Review Leadership ndash Concepts Role of Senior Management Quality

Council Quality Statements Strategic Planning Deming Philosophy Barriers to TQM

Implementation Control on Purchased Product Procurement of various products evaluation of

supplies capacity verification Development of sources procurement procedure Manufacturing

Quality Methods and techniques for manufacture inspection and control of product quality in sales

and services guarantee analysis of claims

Unit-II

Quality Management

Organization structure and design quality function decentralization designing and fitting

organization for different type products and company economics of quality value and contribution

quality cost optimizing quality cost seduction program Human Factor in quality Attitude of top

management cooperation of groups operators attitude responsibility causes of apparatus error and

corrective methods

Unit-III

Control Charts

Theory of control charts measurement range construction and analysis of R charts process

capability study use of control charts

Attributes of Control Chart

Defects construction and analysis of charts improvement by control chart variable sample size

construction and analysis of C charts

Unit -IV

Defects diagnosis and prevention defect study identification and analysis of defects correcting

measure factors affecting reliability MTTF calculation of reliability building reliability in the

product evaluation of reliability interpretation of test results reliability control maintainability zero

defects quality circle

Unit-V

Statistical process control

The seven tools of quality Statistical Fundamentals ndash Measures of central Tendency and Dispersion

Population and Sample Normal Curve Control Charts for variables and attributes Process

capability Concept of six sigma New seven Management tools

Unit-VI

Quality system

Need for ISO 9000 and Other Quality Systems ISO 90002000 Quality System ndash Elements

Implementation of Quality System Documentation Quality Auditing QS 9000 ISO 14000 ndash

Concept Requirements and Benefits

Text Books

1 Lt Gen H Lal ldquoTotal Quality Managementrdquo Eastern Limited 1990

2 Greg Bounds ldquoBeyond Total Quality Managementrdquo McGraw Hill 1994

3 Menon HG ldquoTQM in New Product manufacturingrdquo McGraw Hill 1992

4 Dale HBesterfiled et at Total Quality Management Pearson Education Asia 1999

5 James REvans amp William MLidsay The Management and Control of Quality (5thEdition)

South-Western (Thomson Learning) 2002 (ISBN 0- 324-06680-5)

6 FeigenbaumAV ldquoTotal Quality Management McGraw-Hill 1991

7 OaklandJS ldquoTotal Quality Management Butterworth ndash Hcinemann Ltd Oxford 1989

8 Narayana V and Sreenivasan NS Quality Management ndash Concepts and Tasks New Age

International 1996

9 Zeiri ldquoTotal Quality Management for Engineers Wood Head Publishers 1991

BT-722 5 ElectivendashDesign and Development of Biological Treatment process

Unit-I

Bacterial metabolism in wastewater treatment systems

Introduction decomposition of organic carbon compounds in natural and manmade systems aerobic

and anaerobic decomposition of glucose protein carbohydrates proteins lipids etc Nitrogen

removal during treatment enhanced biological phosphate removal biological removal bio-

transformations and biosorption of metal ions aerobic and anaerobic degradation of xenobiotics

Unit-II

Activated sludge process

Single and two stage process special developments technological and microbiological aspects plant

configurations design

Unit-III

Modeling of aerobic waste water treatment process

Introduction purpose of modeling activated sludge model presentations waste water characteristics

various disinfection methods for waste water

Unit-IV

High rate anaerobic waste water treatment

Introduction basic principles reactor design parameters reactor operation

Unit-V

Biological Nutrient removal

Suspended growth and attached growth nutrient removal processes and design criteria ndash Nitrogen

(Nitrification and denitrification) and Phosphorus precipitation biological) Biological removal of

toxic and recalcitrant organic wastes

Unit-VI

Water reuse

Wastewater reclamation risk assessment various reclamation technologies storage agricultural

reuse industrial reuse groundwater recharge

Text book

1 Joumlrdening HJ and JWinter Environmental Biotechnology - Concepts and Applications

Cambridge University Press 2006

2 George Tchobanoglous and Franlin L Burton Wastewater Engineering- Treatment Disposal and

Reuse Tata McGraw Hill Publishing Co Ltd 1990

BT-722 6 Elective ndash Bioinformatics

Unit I

Introduction to Biological Databases Types Overview of Biological Databases and Retrieve

Nucleic acid databases NCBI PubMed Entrez Blast OMIM Books Taxonomy Structure

Locuslink Protein Databases- Primary Functional Composite Secondary Structural classification

database Sequence Formats amp storage Sequence submission to sequence Database

Unit II

Genomics Structure of DNA Polymorphisms in DNA Sequence Human Genome Project

Complete Genome Sequences Functional Annotation

Unit III

Human Genetic Variation Databases and Concepts Introduction Forms and mechanisms of

genetic variation Databases of human genetic variation SNP databases Mutation databases Genetic

marker and microsatellite databases Nonnuclear and somatic mutation databases Tools for SNP and

mutation visualization

Unit IV

Biological Sequence Analysis amp Characterization Predictive Functional Analysis of coding and

non-polymorphisms Amino Acid Properties and Consequences of Substitutions

Unit V

Genetics Genomics Interfaces Technologies for the measurement of gene expression The Cancer

Genome Anatomy Project (CGAP) The Human Transcriptome Map Protein Interaction Networks

Computational methods for pathways and systems biology databases and web resources

Unit VI

Soft computation Neural Networks and Machine learning support vector machines fuzzy logic

evolutionary computing genetic algorithms- applications to data mining and bioinformatics

Text Books

1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves Noah Hardy

ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd

2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS ISBN978-81-8318minus831minus9

Himalaya Publication House Discovering Genomics Proteomics and Bioinformatics Campbell

ISBN978813171 5598 Pearson Education

3 Proteomics Theory and Practice Gomase VS and Chikhale NJ Himalaya Publication House

4 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978- 3-527-30541-4

John Wiley amp Sons India Pte Ltd

5 Introduction to Bioinformatics Arthur M Lesk Oxford University Press 2003

6 Sequence and Genome Analysis by David W Mount - Cold Spring Harbor Laboratory 1st edition

2004

7 Bioinformatics A Practical Guide to the Analysis of Genes and Proteins by Andreas D

Baxevanis B F Francis Ouellette Wiley-Interscience 3rd Edition 2004

8 Sequence structure and Database ndash Des Higgins Willice Taylor Oxford press 1st edition (2003)

9 Fundamental Concepts of Bioinformatics - Dan E Krane Michael L Raymer Pearson education

First edition (2004)

BT-723 Self Study Open Area Seminar-II

BT-724 Minor Project- II

BT-725 Major Project- I

SEMESTER IV

BT-821 Major Project- II

1

Scheme of Examination amp Syllabus

MTech in Bioinformatics

Delhi Technological University

Main Bawana Road

Delhi -110042

2

MTech in Bioinformatics

Bioinformatics is an emerging discipline of biological science and computer science

mathematics and statistics with the objectives of developing tools to analyze several types

of biological data and generate new knowledge for existing life in universe

Bioinformatics has two subfields the development of computational tools and databases

and the application of these tools and databases in generating biological knowledge to

better understanding living systems These fields are complementary to each other The

tools development includes writing software for sequence structural and functional

analysis as well as construction and curating of biological databases

It is clear that the promise of bioinformatics and advanced level RampD in its field will be

fulfilled by those who have sound background of Biological science computer science

mathematics and statistics The proposed syllabus has been developed to address the

need of well trained bioinformaticians cutting edge RampD for this field bioinformatics

entrepreneurship and bioinformatics-business management The trained manpower will

be well versed in techniques of modern biology biochemistry strong skills in

combinatorial computing and search and retrieval techniques in large biological

databases

3

Delhi Technological University Delhi

Department of Biotechnology

Scheme of Examination

MTech in Bioinformatics

Semester I

Sem I Course

Code

Subject

L T P Internal

Marks

End

sem

Marks

Total

Marks

Credits

Group A BT-501 Advanced Proteomics 3 0 0 50 100 150 3

BT-502 Bioinformatics I 3 0 0 50 100 150 3

BT-503 Population Genetics 3 0 0 50 100 150 3

BT-504 Bioinformatics I

Laboratory

0 0 2 30 70 100 2

Group B BT-551 Biostatistics 3 0 0 50 100 150 3

BT-552 High-Throughput

Structural Biology

3 0 0 50 100 150 3

BT-553 High-Throughput

Structural Biology

Laboratory

0 0 2 30 70 100 2

BT-554 Self Study Open Area

Seminar

0 0 1 50 -- 50 1

Total 360 640 1000 20

4

Semester II

Semester III

Course

Code

Subject

L T P Internal

marks

End

sem

marks

Total

Marks

Credits

Group E BT-701 Professional Elective V 3 0 0 50 100 150 3

BT-702 Professional Elective VI 3 0 0 50 100 150 3

BT-703 Self Study Open Area

Seminar

0 0 2 100 --- 100 2

BT-704 Minor Project - II 0 0 2 -- 300 300 6

BT-705 Major Project-I 0 0 4 300 300 6

Total 200 800 1000 20

Course

Code

Subject

L T P Internal

Marks

End

sem

Marks

Total

Marks

Credits

Group C BT-601 Bioinformatics II 3 0 0 50 100 150 3

BT-602 Professional Elective I 3 0 0 50 100 150 3

BT-603 Professional Elective II 3 0 0 50 100 150 3

BT-604 Bioinformatics II

Laboratory

0 0 2 30 70 100 2

Group D BT-651 Professional Elective III 3 0 0 50 100 150 3

BT-652 Professional Elective IV 3 0 0 50 100 150 3

BT-653 Lab based on Elective

III

0 0 2 30 70 100 2

BT-654 Minor Project ndash I 0 0 1 50 -- 50 1

Total

360 640 1000 20

5

Semester IV

Subject

Code

Subject

L T P Internal

marks

End sem

marks

Total

marks

Credits

Group F BT-801 Major Project - II 0 0 15 400 600 1000 20

Total

400 600 1000 20

BT-602 Professional Elective I

BT-6021 Biological Database Management

BT-6022 Advanced Genetic Engineering

BT-6023 Web Application Development

BT-603 Professional Elective II

BT-6031 Computational Genomics

BT-6032 Drug Design and Discovery

BT-6033 Chemoinformatics

BT-651 Professional Elective III

BT-6511 Computer Aided Drug Design

BT-6512 Computer Graphics

BT-6513 Pharmacogenomics and Personalized Medicine

6

BT-652 Professional Elective IV

BT-6521 Combinatorial Methods in Biopharmaceuticals

BT-6522 Data Warehousing and Data mining

BT-6523 Genomics From Human Genome Project to Medical Applications

BT-653 Professional Elective-III Laboratory

BT-6531 Computer-Aided Drug Design Laboratory

BT-6532 Computer Graphics Laboratory

BT-6533 Pharmacogenomics and Personalized Medicine Laboratory

BT-654 Minor Project-I

BT-701 Professional Elective V

BT-7011 Immunoinformatics

BT-7012 Medical Bioinformatics

BT-7013 Advanced Genetic Engineering

BT-702 Professional Elective VI

BT-7021 Nanotechnology in health care

BT-7022 Resource Planning amp Management in Bioinformatics

BT-7023 Advanced Drug Delivery Systems

7

SYLLABUS

MTECH (BIOINFORMATICS)

Semester I

Group-A

BT-501 Advanced Proteomics

Unit I

Introduction The proteome and the Genome life and death of a protein protein a

modular structure functional protein families need for proteomics scope of proteomics

challenges of proteomics Strategies for protein separation Two-dimensional

polyacrylamide gel electrophoresis for proteome analysis Brief history of 2-DE 2-DE

with immobilized pH gradients sample preparation solubilization Reduction The first

dimension IEF with IPG Equilibration between dimensions The second dimension

SDS-PAGE resolution reproducibility of 2-DE liquid chromatography in proteomics

Unit II

Detection of proteins in polyacrylamide gels and on electroblot membranes Organic

dyes and silver stains Reverse stains Colloidal dispersion stains organic fluorophore

stains metal chelate stains Image analysis of two-dimensional gels Data acquisition

digital image processing Protein spot detection and quantification Gel matching Data

analysis data presentation data bases

Unit III

Enhancing high-throughput proteome analysis the impact of stable isotope labeling

Sample preparation two-dimensional gel separation and analysis Mass spectrometry

8

protein identification using MS data Mass spectrometry protein identification using

MSMS data Protein modification in proteomics Introduction phosphor-proteins

glycoproteins Ubiquitin etc

Unit IV

Protein-Protein interactions- Yeast two hybrid Co-Precipitation Phage Display

Phylogenetic Profile Domain fusion Gene Neighborhood Gene Cluster Mirror Tree

Analysis of genome wide Protein-Protein Interactions in yeast Genome wide yeast two

hybrid analysis of other organisms Protein fragment complementation assays

Unit V

Protein chips and functional proteomics Introduction different types of protein chips

detection and quantification of proteins bound to protein chips emerging protein chips

technologies

Unit VI

Applications of Proteome analysis Mining proteomes protein expression profile

identification of protein-protein interactions and protein complexes mapping proteins

complexes recent advances in Proteomics

Reference Books

1 Proteomics From Protein Sequence to Function by SR Pennington and MJ

Dunn Viva Books Private Limited (2001)

2 Introduction to Proteomics by Daniel C Liebler Humana Press

3 Discovering Genomics Proteomics amp Bioinfo AM Campbell CSH

Press(2003)

4 Handbook of Comparative Genomics Principles and Methodology by Cecilia

Saccone Graziano Pesole Wiley-LISS Publication (2003)

5 Comparative Genomics by Melody S Clark Kluwer Academic Publishers (2001)

9

BT -502 Bioinformatics I

Unit I

Introduction to Biological Databases Types Overview of Biological Databases and

Retrieve Nucleic acid databases NCBI Protein Databases- Primary Functional

Composite Secondary Ensembl Sequence Formats amp storage Sequence submission to

sequence Database

Unit II

Genomics Structure of DNA Polymorphisms in DNA Sequence Types of SNPs

Human Genome Project Genetic Association Studies HapMap Project

Unit III

Protein Functional Annotation and Characterization Gene Ontology GO

Annotations Manual Annotations Computational Annotation Methods Functional

Analysis of Datasets

Unit IV

Pairwise Sequence Alignment Local alignment Global alignment Scoring matrices

PAM BLOSUM Gaps Dot Plots Dynamic programming Approach Needleman and

Wunsch Algorithm Smith and waterman Algorithm Heuristic Approach BLAST

FASTA

Unit V

Multiple Sequence Alignment and Phylogenetic Analysis Algorithms for multiple

sequence alignments global and local alignment programs and methods for multiple

sequence alignment Algorithms for alignment Phylogenetic Analysis

Unit VI

Introduction to Perl Programming Introduction and Installation Arithmetic and

10

Logical operators Conditionals and Loops List and Arrays Working with files

Reference Books

1 Introduction to Bioinformatics Arthur M Lesk Oxford University Press 2003

2 Sequence and Genome Analysis by David W Mount - Cold Spring Harbor

Laboratory 1st edition 2004

3 Bioinformatics A Practical Guide to the Analysis of Genes and Proteins by

Andreas D Baxevanis B F Francis Ouellette Wiley-Interscience 3rd Edition

2004

4 Sequence structure and Database ndash Des Higgins Willice Taylor Oxford press 1st

edition (2003)

5 Fundamental Concepts of Bioinformatics - Dan E Krane Michael L Raymer

Pearson education First edition (2004)

6 Beginning Perl for Bioinformatics James Tisdall OrsquoReilly 1st Edn 2001

BT -503 Population Genetics

Unit I

Introduction Scope amp Premises of Population Genetics Genetic and Phenotypic

Variation Random Mating Loci and alleles Mutations and Polymorphisms Genotype

and Allele Frequencies Effect of Mutations on Fitness Rate of Spontaneous Mutation

Unit II

Population Structure The Hardy-Weinberg Principle Testing for Hardy-Weinberg

Equilibrium Extensions of the Hardy-Weinberg Principle Linkage and Linkage

Disequilibrium Genetic Drift The Wright-Fisher Model of Random Genetic Drift

Effective Population Size Gene Trees and Coalescence Mutation The Neutral Theory

Recombination Migration Inbreeding and Heterosis Darwinian Selection Selection in

Haploid Organisms Selection in Diploid Organisms Overdominance More Complex

Types of Selection Molecular Population Genetics Molecular Polymorphisms Patterns

of Change in Nucleotide and Amino Acid Sequences Polymorphism and Divergence

11

Molecular Phylogenetics Transposable Elements mtDNA Y-DNA Separating History

from Gene Flow

Unit III

Population Genomics and proteomics Genome-Wide Patterns of Polymorphism

Human Population Genetics Human Polymorphism Population Genetic Inferences from

Human SNPs Population Structure Inferred from Human Polymorphism Mendelian

Disease and Population Genetics Genetic Basis for Variation in Risk of Complex

Disease Human Origins

Unit IV

Evolutionary Analysis Quantitative Genetics Quantitative Genetics of Natural

Populations Quantitative Trait Loci (QTLs) Types of Quantitative Traits Genes That

Affect Quantitative Traits the Number of Genes Affecting Quantitative Traits Methods

for Mapping QTLs

Unit V

Selection Measures of Fitness amp Constant Fitness Models Nonrandom Mating Identity

by descent Inbreeding Selection on Quantitative Traits Pleiotropy and Developmental

Constraints Interactions of selection with other evolutionary forces The Shifting Balance

Theory The Unit of Selection Meiotic and Molecular Drive Sexual Frequency amp

Density Dependent Selection

Unit VI

Genetic Variability in Natural Populations Introduction Measures of Genetic

Variation Gene Diversity within Populations- Enzyme and Protein Loci Blood Groups

and other loci Genetic Diversity in Subdivided Populations Mechanisms of Maintenance

of Protein Polymorphisms Overdominance hypothesis Other types of Balancing

Selection Neutral Mutations Transient Polymorphisms due to selection

Reference Books

12

1 Evolutionary Analysis Scott Freeman John C Hendon Fourth Edition Pearson

Education

2 Molecular Genetic Analysis of Populations Hoelzel 2nd Edition Oxford

University 1998

3 Genetics -Principles and Analysis Hartl and Jones 5th edition Jones and Barlet

2001

4 Genetics of Populations P W Hedrick 2nd Edition Jones amp Bartlett 2000

5 Principles of Population Genetics Hartl amp Clark Third Edition Sinauer

Associates Inc 1997

BT-504 Bioinformatics-I Laboratory

1 Inter-conversion different sequence file format

2 Database Searching using Entrez and SRS

3 Study of Databases and Data retrieval

4 Dot Matrix Alignments

5 Needleman Wunsch Alignments

6 Smith Waterman Alignments

7 Multiple Sequence Alignment

8 Phylogenetic Analysis

9 Perl Programs

13

Group B

BT-551 Biostatistics

Unit 1

Random variable and Expectation Random variable and distribution function Jointly

distributed random variables Mathematical expectation Statistical parameters Moment

generating function Chebyshevrsquos inequality

Unit 2

Probability Distributions Binomial distributions Multinomial distribution Geometric

distribution Poisson distribution Normal distribution Normal distribution as limiting

case of Binomial distribution Exponential distribution

Unit 3

Correlation and Regression Method of least square and curve fitting Correlation Karl

Pearsonrsquos coefficient of linear correlation Probable error Rank correlation and

Spearmanrsquos coefficient Regression

Unit 4

Sampling distributions and Large sample estimation Sampling plans Statistics and

sampling distributions The central limit theorem The sampling distribution of the

sample mean The sampling distribution of the sample proportion Tests of significance

Large samples testing Sampling of attributes

Unit 5

Exact sampling distributions and small sample test The Chi-square distribution

Studentrsquos t-distribution Snedecorrsquos F- distribution Their Properties and applications

14

Unit 6

ANOVA One - way analysis of variance Two - way analysis of variance Three - way

analysis of variance

Reference Books

1 Pagano M and Gaureau K lsquoPrinciples of Biostatisticsrsquo 7th ed Thomson

Learning2007

2 Ross SM lsquoProbability and Statistics for Engineers and Scientistsrsquo 3rd ed

Academic Press 2005

3 Walpole RE Myers RH MyersSL Ye K lsquoProbability and Statistics for

Engineers and Scientistsrsquo Prentice Hall Inc 2002

4 Taneja HC lsquoStatistical Method for Engineering and Sciencesrsquo IK

Intenational2009

BT-552 High-Throughput Structural Biology

Unit I

Introduction Peptide Bonds hydrogen bonding ionic and hydrophobic interactions

Protein Structure Reverse Turns and Organized Folds Structure Classification Folding

Mechanisms Bond lengths bond angles and torsion angles Degrees of freedom Cyclic

molecules Rotation about a bond Eulerian angles Helices and their notations Analysis

and manipulation of structures Ramachandran plots Chaperones and Chaperonins

Structure Determination Dynamics Simulation Protein Folding Nucleic Acid Structure-

DNARNA Structural Biology for the Optimization of Gene Therapy Vectors Hands-on

assembly of amino acid and nucleotide dimer CPK models

Unit II

X-Ray Crystallography Computing amp NMR Structure Determination X-ray

Crystallography Computing The Phase Problem Least Square Solutions Entropy

Maximization Indirect Methods NMR Structure Determination Nuclear Magnetic

Resonance Distance Geometry Distance-based Modeling Structural Analysis

15

Unit III

Optical spectroscopy Absorbance spectrum and melting of a protein circular

dichroism molecular chirality structural transitions of macromolecules and analysis of

spectral results ligand binding and cell sorting Circular dichroic spectrum and melting

of a protein radiation radioactive decay particle detection liquid scintillation surface

plasmon resonance Thermodynamics of macromolecular transitions Mass spectroscopy

application to complex proteins Diffraction overview crystallization wavevector math

and scattering scattering from a periodic lattice reciprocal space and symmetry

multiwavelength anomalous diffraction and crystallographic statistics

Unit IV

Potential Energy Minimization Potential Energy Function Local Optimization Global

Optimization Energy Transformation

Unit V

Molecular Dynamics Simulation Equations of Motion Initial-Value Problem

Boundary-Value Problem Normal Mode Analysis

Unit VI

Knowledge-based Protein Modelling SequenceStructural Alignment Fold

RecognitionInverse Folding Knowledge-based Structural Refinement Structural

Computing Comparative and ab initio modelling

Reference Books

1 Principles of Biochemistry D L Nelson and MM Cox Lehninger W H

Freeman Fourth Edition 2004

2 Structural Genomics and High-Throughput Structural Biology Michael

Sundstroumlm Martin Norin Aled Edwards CRC Press 2006

3 The Physical Basis of Biochemistry The Foundations of Molecular Biophysics

PR Bergethon Springer Corrected edition 2000

16

4 Principles of Physical Biochemistry KE van Holde CJohnson and PShing Ho

Prentice Hall Second edition 2005

5 Lecture Notes on Computational Structural Biology Zhijun Wu World Scientific

Publishing Co Pte Ltd 2008

BT-553 High-Throughput Structural Biology Laboratory

1 Chemical modification of proteins

2 Peptide mapping

3 Analysis of amino acid composition

4 Analysis and interpretation of spectrophotometric data for denaturation studies

5 Analysis of CD data

6 Analysis and interpretation of NMR data

7 Crystallization of Lysozyme ndash pH driven and salt driven crystallization Effect of

concentration BMCD

8 Analysis and interpretation of X-Ray crystallographic data

9 Public domain software for structure modeling and visualization

BT -554 Self Study Open Area Seminar

17

Semester II

Group C

BT-601 Bioinformatics II

Unit I

Human Genetic Variation Databases of human genetic variation SNP databases

Mutation databases Tools for SNP and mutation visualization

Unit II

Biological Sequence Analysis amp Characterization Predictive Functional Analysis of

coding and non-polymorphisms Amino Acid Properties and Consequences of

Substitutions

Unit III

Genotype-Phenotype Mapping Relationship between genotypes and phenotypes

Genetic programming and its influence on phenotypes Monogenic and complex

disorders Interplay of genetic and environmental factors Integration of clinical and

molecular data Understanding the factors influencing disease susceptibility

Unit IV

Soft computation Machine learning Supervised and Unsupervised Methods Artificial

Neural Networks support vector machines fuzzy logic applications to data mining and

bioinformatics

18

Unit V

Pharmacogenomics and Pharmacogenetics Introduction Pharmacogenetics Drug

Response Single Nucleotide Polymorphism Case Study Pharmacogenomics Databases

OpenPGx Consortium

Unit VI

Bioinformatics Applications and Case Studies Novel Data Annotation and Curation

Pharmacogenomics Applications Database Creation Development of a Predictive Tool

Reference Books

1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves

Noah Hardy ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd

2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS ISBN978-

81-8318minus831minus9 Himalaya Publication House

3 Discovering Genomics Proteomics and Bioinformatics Campbell

ISBN978813171 5598 Pearson Education

4 Proteomics Theory and Practice Gomase VS and Chikhale NJ Himalaya

Publication House

5 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978-3-

527-30541-4 John Wiley amp Sons India Pte Ltd

BT-602 Professional Elective I

BT-6021 Biological Database Management

Unit I

Introduction to Database Systems Overview File Systems vs DBMS Advantages of

DBMS Describing and Storing Data in DBMS Queries in a DBMS Structure of a

DBMS Exercises

19

Unit II

Relational Databases for Bioinformatics Relational Queries Relational Algebra amp

Calculus SQL Queries Programming amp Triggers Query by Example From relational

algebra to SQL

Unit III

Data Storage and Indexing File Organizations amp Indexes Tree-Structured amp Hash-

Based Indexing

Unit IV

Introduction to biological databases Nucleic acid and protein sequence data banks

GenBank EMBL DDBJ TrEMBL GenPept nucleotide sequence databank cDNA

databanks AIDS Virus sequence data bank rRNA data bank NBRF-PIR SWISSPROT

Signal peptide data bank etc

Unit V

Design of Biological Database System for Bioinformatics Schema Refinement amp

Normal Forms Physical Database Design amp Tuning Database Security amp Access

Control

Unit VI

Advanced DBMS Topics Parallel amp Distributed Databases Internet Databases Data

Mining Object-Database Systems Spatial Data Management

Reference Books

1 Database System Concept By CJ Date

2 Database System By Aho Ullman

3 Database Systems By Rob Coronel

4 Database Management Systems Raghu Ramakrishnan amp Johannes Gehrke

Second Edition

20

5 Database Modeling and Design Logical Design Toby J Teorey Sam S

Lightstone Tom Nadeau Publisher Morgan Kaufmann 4th Edition 2005

BT-6022 Plant Bioinformatics

Unit I

Plant Databases and Resources NCBI MIPS TAIR ArEnsEMBL Legume Maize

and Barley Resources

Unit II

Methods for Analysis of Gene Expression in Plants MPSS Classification of mRNA

Signatures Genomic Database MPSS Expression Database

Unit III

Metabolomics Data Analysis Visualization and Integration GC-MS HPLC-MS and

UPLC-MS Metabolic Profiling Methods

Unit IV

KEGG Bioinformatics Resource for Plant Genomics Research Pathway Maps

SSDB EXPRESSSION BRITE LIGAND GENOME

Unit V

Automated Discovery of Single Nucleotide Polymorphism and Simple Sequence

Repeat Molecular Genetic Markers SSR Discovery SNP Discovery SSRPrimer

SNPServer

Unit VI

Methods for Gene Ontology Annotation Web Sites for Browsing GO GO

Annotations Manual Annotations Computational Annotation Methods Functional

Analysis of Datasets

21

References

1 Plant Genomics Methods and Protocols Daryl J Somers Peter Langridge and J

Perry Gustafson Humana Press 2009

2 Plant Bioinformatics Methods and Protocols David Edwards Humana Press

2007

3 Biotechnology in Agriculture and Forestry Plant Metabolomics K Saito RA

Dixon and LWillmitzer Springer-Verlag Berlin Heidelberg 2006

4 Plant Genomics and Proteomics CHRISTOPHER A CULLIS John Wiley amp

Sons Inc 2004

5 Data Mining for Genomics and Proteomics Darius M Dziuda John Wiley amp

Sons Inc 2010

BT -6023 Web Application Development

Unit I

Perl Programming

Introduction and Installation

Unit II

Data types Arithmetic and Logical operators Conditionals and Loops List and Arrays

Working with files Regular Expression and Pattern Matching Bioperl installation and

any two related modules

Unit III

MySQL CGI and PHP Installing MySQL MySQL Programs Working with Data

MySQL Privileges

Unit IV

MySQL and Perl Perl DBI Connect Statement Handles Error Handling Server

Admin

22

Unit V

Apache Understanding Apache Installation Configuration

Unit VI

Database Creation using Perl Apache amp MySQL

Reference Books

1 Perl and Apache Adam McDaniel Wiley Publishing Inc 2010

2 Beginning Perl for Bioinformatics James Tisdall OrsquoReilly 1st Edn 2001

3 Developing Web Applications with Apache MySQL memcatched and Perl

Patrick Galbraith Wiley Publishing Inc 2009

4 Beginning Perl Development Steve Suehring Springer-Verlag New York Inc

2006

5 Database Management Systems Raghu Ramakrishnan amp Johannes Gehrke

Second Edition

BT-603 Professional Elective II

BT-6031 Computational Genomics

Unit I

DNA Sequencing Principles of DNA sequencing Pyrosequencing Automated DNA

sequencing Shotgun sequencing ndash contig assembly High through put sequencing

Double Digest Problem DNA double digest problem multiple solutions to double

digest problem Algorithm for DDP- Integer programming Partition problem and

travelling salesman problem probed partial digest problem homometric sets

23

Unit II

Cloning and clone libraries libraries by complete and partial digestion Gene mapping

mapping with unique and non-unique probes optical mapping interval graphs mapping

with restriction fragment fingerprints Lander-Waterman statistics screening clone

libraries radiation hybrid mapping

Unit III

Genome mapping Commonly Used DNA Markers SNPs or single nucleotide

polymorphisms Genetic Mapping and Physical Mapping alternating Eulerian cycles

transformations in Eulerian cycles Radiation maps STS NCBI and Map Integration

NCBIs Map Viewer Human Genome DNA analysis for health care Study of Model

Species

Unit IV

Functional Genomics DNA arrays sequencing by hybridization (SBH) positional

sequencing by hybridization SBH and the shortest superstring problem SBH and the

Eulerian path problem probability of unique sequence rearrangements string

rearrangements design of DNA microarrays fidelity probes for DNA arrays ESTs

Digital Northerns SAGE Relational Data Base cDNA Microarrays Oligonucleotide

Microarray Chips Cancer and Genomic microarrays Examples for application of

Microarrays Microarrays Data Analysis Gene finding tool

Unit V

Gene expression analysis Gene Control in Prokaryotes and Eukaryotes Structural

Motifs in Eukaryotic Transcription Factors Softwares for Motif Finding SAGE

SAGEmap GEO Profiles GEO DataSets GEO BLAST GEO DataSet Cluster Analysis

Gene Expression Data Analysis cDNA ESTs dbEST and Gene expression study

24

Unit VI

Gene prediction

Gene finding composition based finding sequence motif-based finding Finding of ORF

CpG Island Exons-Introns boundaries Splice site Homology Ab initio gene prediction

program Type of Gene prediction methods and algorithms Eukaryotic gene finding

Gene model in most gene finders Promoter Region Transcriptions Factor and Signals

GENSCAN FGENESH FGENES Promoter recognition programs TSSG NSITE

Pattern Search program Motif representation consensus regular expressions PSSMs

Markov models Other features of nucleic acid sequencing Protein motifs amp domains

Reference Books

1 Bioinformatics Genomics and Post-Genomics Freacutedeacuteric Dardel Franccedilois Keacutepegraves

Noah Hardy ISBN 978-0-470-02001-2 John Wiley amp Sons India Pte Ltd

2 Bioinformatics Theory and Practice Chikhale NJ and Gomase VS

ISBN978minus81minus8318minus831minus9 Himalaya Publication House

3 Discovering Genomics Proteomics and Bioinformatics Campbell

ISBN97881317155 98 Pearson Education

4 Essentials of Genomics and Bioinformatics Christoph W Sensen ISBN 978-3-

527- 30541-4 John Wiley amp Sons India Pte Ltd

5 Introduction to Computational Genomics A Case Studies Approach Nello

Cristianini Matthew W Hahn ISBN-139780521671910 Cambridge University

Press India Private Limited

BT-6032 Drug Design and Discovery

Unit I

Drug Discovery Organized Drug discovery and development Source of drugs

Pharmacological Microbial Recombinant Biochemical and Molecular level screening

systems and their construction strategies

25

Unit II

Approaches to New Drug Discovery Alternative strategies in Lead identification Lead

optimization Preclinical development Clinical trials Patenting and clearance for

application

Unit III

Enzymes as Targets of Drug Design Enzyme kinetics Enzyme inhibition and

activation Approaches to the Rational Design of Enzyme Inhibitors Structures of

enzyme stereochemistry of substrate binding site concept of subsites design of substrate

analogs structure based design of inhibitors enzyme inhibitor interactions binding

constant lock and key mechanism induced fit mechanism inhibitors as drug enzyme

inhibitor complexes recognition of new elements in the binding site development of

tight inhibitors Enzyme kinetics Enzyme inhibition and activation Approaches to the

Rational Design of Enzyme Inhibitors

Unit IV

Receptors as Targets of Drug Design Receptor Theory Lead Compound Discovery of

Receptor agonists and antagonists Receptor Complexes and Allosteric Modulators

Molecular Biology of Receptors Receptor Models and Nomenclature Receptor Binding

Assays Lead Compound Discovery of Receptor agonists and antagonists Natural

Product Sources Pharmacophore-based Ligand Libraries Diversity-based ligand

libraries High-throughput screening Receptor versus enzyme mediated drug action SAR

and its quantitative description QSAR Molecular principles in agonist and antagonist

action Thermodynamic and structural principles Objectives and approaches in the native

ligand modification Molecular graphic and dynamical methods in peptide and protein

mimicry Morphinans versus Enkephalins paradigm example of a peptido-mimetic

Other illustrative examples from current literature Drug design by receptor site fit

Active site simulations using PDB structure data and homology modeling Graphical and

computational active site fits exploiting small structure data libraries and commercial

softwares

26

Unit V

Computational Tools and Techniques Homology Model Building Molecular

Mechanics Protein Folding Docking Pharmacophore Models QSAR 3D-QSAR

Quantum Mechanics in Drug Design Cheminformatics

Unit VI

Current status and future prospects Synthetic Peptide libraries Peptide libraries

through Phage Display Applications in Epitope and Agretope mapping and in synth etic

vaccine design Artificial combinatorials Peptides bezodiazepines and other current

examples Selection strategies and screening methodologies Perspectives in Gene

Therapy Human Genome Project and its possible impact Prodrug Design and

Applications

Text Books

1 Comprehensive Medicinal Chemistry C Hansch (Ed) (Vols I-VI) Academic

Press 1990

2 Design of Enzyme Inhibitors as Drugs M Sandler and H J Smith Oxford Univ

Press 1989

3 Drug Discovery and Design Medical Aspects J Matsoukas and T

Mavromoustakos IOS Press 2002

4 Drug Design Cutting Edge Approaches Darren R Flower The Royal Society of

Chemistry Cambridge 2002

5 Protein Folding and Drug Design R A Broglia and L Serrano IOS Press 2007

BT-6033 Chemoinformatics

Unit I

Role of computers in chemical research Introduction to Chemoinformatics

Representation and manipulation of 2D and 3D molecular structures Chemical Databases

- Design Storage amp Retrieval methods

27

Unit 2

Representation of Molecules and Chemical compounds and reactions Different types of

Notations SMILES Coding Structure of Mol files and Sd files( Molecular converter

SMILES Translator)Similarity search of the molecule (Zinc Database)

Unit 3

Reaction databases Representation of chemical reactions Search techniques (Full Sub

and Super structure) Similarity searches Modeling of small molecules

Unit 4

Virtual screening and compound filtering biologically active compounds virtual and

high throughput screening filter functions

Unit 5

Combinatorial chemistry and Library design -Introduction Diversed and focused

Libraries Combinatorial library design strategies Product-based library design Multi-

objective library design

Unit 6

Analysis of high-throughput screening data- Introduction Data visualization Data

mining methods Prediction of ADMET properties QSAR Analysis model building and

model evaluation Chemoinformatics tools for drug discovery

Reference Books

1 Chemoinformatics theory practice amp products by Bary A Bunin Springer

2 Chemoinformaticsa textbook by Johann Gasteiger Wiley

3 Methods in molecular biology volume 201 Combinatorial library methods and

protocol edited by Lisa Bellavance English Humana Press

4 An introduction to chemoinformatics by Andrew R Leach Valerie J Gillet

Kluwer Academic Publishers

28

BT -604 Bioinformatics-II Laboratory

1 SNP and Mutation Databases

2 Gene Ontology

3 Predictive Functional Analysis of SNPs ndash SIFT PolyPhen

4 Pharmacogenomics Databases

BT-651 Professional Elective III

BT-6511 Computer Aided Drug Design

Unit I

Introduction Introduction to CADD SBDD Representation of Molecular Structures

Chemical Nomenclature and Structure Representation Processing Constitutional

Information Representation of 3D Structures Molecular Shape Analysis Representation

of Chemical Reactions

Unit II

Virtual Screening Virtual Screening Chemoinformatics in Lead Discovery

Computational Chemistry Molecular Complexity and Screening Set Design Algorithmic

Engines in Virtual Screening Strengths and Limitations of Pharmacophore-Based Virtual

Screening

Unit III

Lead Discovery High Throughput Screening Hit and Lead Discovery Enhancing Hit

Quality and Diversity within Assay Throughput Constraints Molecular Graphics

Molecular Dynamics and Simulation of Lead Molecular Diversity in Lead Discovery

From Quantity to Quality In Silico Lead Optimization

29

Unit IV

Databases and Libraries Databases and Libraries PubChem PubEchm-BioAssay

Pharma Project Drug Bank WOMBAT World of Molecular Bioactivity Cabinet -

Chemical and Biological Informatics Network Structure Modification in Chemical

Databases Rational Design of GPCR-specific Combinational Libraries Based on the

Concept of Privileged Substructures

Unit V

Molecular docking amp Simulation de novo pharmacophore elucidation drug design for

structurally well-defined receptor targets like HIV protease inhibition ER antagonism

H2 receptor antagonism Chirase inhibition (quinoline derivative antibiotics) and ACE

inhibition macromolecule-ligand docking docking algorithms AUTODOCK Molecular

dynamic simulations relative energy energy minimization methods ligand binding free

energy calculations (both simulation and empirical methods) intermolecular interactions

forces related to drug binding force-field calculation including solvation role of

solubility in drug binding and pKa Poisson-Boltzmann Surface Area (PBSA) AMBER

GROMOS and GROMACS

Unit VI

CADD Applications CADD Applications A Practical Strategy for Directed Compound

Acquisition Efficient Strategies for Lead Optimization Chemoinformatics Tools for

Library Design Hit-to-Lead Process A Users Perspective Application of Predictive

3DQSAR Models to Database Mining Drug Discovery - Case Study

Reference Books

1 Computer Applications in Pharmaceutical Research and Development Wang

Binghe ISBN-10 0-471-73779-8 John Wiley amp Sons India Pte Ltd

2 Engineering Chemistry RV Gadag and A Nityananda Shetty ISBN

8188237833 IK International Publishing House Pvt Ltd

3 Virtual Screening in Drug Discovery Juan Alvarez and Brian Shoichet ISBN-13

978-0824754792 CRC Press

30

4 Biological Thermodynamics Donald T Haynie ISBN9780521704045

Cambridge University Press India Private Limited

5 Chemoinformatics in Drug Discovery Tudor I Oprea Raimund Mannhold Hugo

Kubinyi Gerd Folkers ISBN 978-3-527-30753-1 John Wiley amp Sons India Pt L

BT - 6512 Computer Graphics

Unit I

Graphic Systems Refresh CRT raster-scan displays DVST plasma displays LCD

Unit II

Input devices functions provided by input devices basic working of these input

devices image scanners touch panels Input modes request mode event mode

Unit III

Output Primitives Points lines DDA Bresenham live amp circle drawing algorithm

ellipse generation

Unit IV

Filled area Primitives scan line polygon fill algorithm inside outside tests boundary

fill algorithm Line width color color and gray levels character attributes

Unit V

Two-dimensional Geometric Transformation Basic transformation translation

rotation scaling fixed point scaling general scaling direction The viewing pipeline

window viewpoint transformation Line clipping algorithms

Three Dimensional concepts Polygon surfaces plane equation curved lines and

surfaces quadric surfaces spline representation spline specification Bezier curves and

surfaces B-splines and surfaces Displaying spline curves and surfaces Hornerrsquos rule

31

Three-Dimensional transformation and viewing methods 3 D transformations viewing

co-ordinates transformation from world to viewing co-ordinates parallel and perspective

projections Back face detection depth-buffer and A-buffer methods

Unit VI

3D Object Representation Visible Surface Algorithms Curves and Surfaces in

Computer Graphics Introduction to Ray Tracing and Radiosity methods Anti-aliasing

Shadow generation Texture mapping Effects Fractals Image Coding Color

Reference Books

1 Computer Graphics by DHearn and MP Baker

2 Computer Graphics - A programming approach by Harriyton

3 Procedural Elements of Computer Graphics by Roger

4 Three Dimensional Computer Graphics by Folley and Dam

5 Computer Graphics Principles and Practice James Foley Andries van Dam

Steve Feiner and John Hugues Second Edition

BT-6513 Pharmacogenomics and Personalized Medicine

Unit I

Introduction to Pharmacogenomics The roots of pharmacogenomics Historical

Perspectives and Current Status

Unit II

The Human genome Computational genome analysis

Unit III

Functional Analysis of Gene Variation amp Genotyping Techniques Aspects

influencing method of selection SNP Genotyping TaqMan Genotyping

32

Unit IV

Pharmacogenomics in drug discovery The need of protein structure information

protein structure and variation in drug targets-the scale of problem Mutation of drug

targets leading to change in the ligand binding pocket

Unit V

Case Studies

Unit VI

Management of Pharmacogenomic Information PharmGKB

Reference Books

1 Pharmacogenomics The Search for the Individualized Therapiesrdquo Licinio Julio

and Ma-Li Wong Wiley-VCH 2002

2 Pharmacogenomics An Approach to New Drugs Development Chakrabarthy

Chiranjib and Bhattacharyya Atane 2004

3 Pharmacogenomics Social Ethical and Clinical Dimensions Rothstein Mark A

Wiley-Liss 2003

4 Pharmacogenomics in Drug Discovery amp Development Qing Yan Humana

Press 2008

5 Pharmacogenomics Methods and Protocols Federico Innocenti Humana Press

2005

BT-652 Professional Elective IV

BT -6521 Combinatorial Methods in Biopharamaceuticals

Unit I

Introduction The Original Combinatorial Chemist ndash Biopolymers constitute natural

libraries ndash Selection and evolution ndash The expression of genetic information

33

Combinatorial assembly of antibody genes ndash Molecular solutions to Combinatorial

problems

Unit II

Synthetic Peptide Libraries Solid-Phase peptide synthesis ndash Peptide on pins ndash Other

iterative disconvolution strategies Examples of SplitCoupleMix Peptide Libraries ndash

Positional Scanning

Unit III

Supports Linkers and Reagents for peptide and small molecule synthesis

Polystyrenes ndash PEG ndash Grafted supports ndash Coupling strategies ndash New resins and linkers ndash

Ring ndash forming cleavage ndash loading

Unit IV

Supported Solution ndash Phase Synthesis Polyethylene glycols ndash Dendrimers Fluorous

synthesis ndash Solution ndash Phase parallel synthesis scavenging resins ndash Ion Exchange resins ndash

Supported reagents ndash Flourous reagents ndash Solid phase extraction ndash Gas Phase separation

Unit V

Analytical Methods for Solid-Phase Synthesis Product identification ndash Gel Phase

NMR ndash High resolution magic angle spinning NMR on-bead infrared Spectroscopy ndash

Mass Spectroscopy ndash Non-Spectroscopic Methods- Product identification ndash Gel Phase

NMR ndash High resolution magic angle spinning NMR on-bead infrared Spectroscopy ndash

Mass Spectroscopy ndash Non Spectroscopic Methods

Unit VI

A Combinatorial Approach to Gene Expression Analysis DNA Microarrays DNA

Microarray Components Characteristics and Technology Fabrication Target

Preparation and Labelling Procedures Hybridization and Washing Target Detection

Analysis Applications of the Microarray Technology

34

Reference Books

1 Fenniri Hicham lsquoCombinatorial Chemistryrsquo Oxford University Press 2000

2 Block JH and Beale JM lsquoWilson amp Gisvolds Text book of Organic Medicinal

and Pharmaceutical Chemistryrsquo 11th Edition Lippincott Williams amp Wilkins

2004

3 Fassina G ldquoCombinatorial Chemistry and Technologies Methods and

Applicationsrdquo 2nd Edition CRC Press 2005

4 Combinatorial Chemistry Synthesis Analysis Screening Gunther Jung

WILEY-VCH Verlag GmbH 2001

5 Handbook of Combinatorial Chemistry Drugs Catalysts Materials K C

Nicolaou Wiley-VCH 2002

BT -6522 Data Warehousing and Data Mining

Unit I

Data Warehousing and Business Analysis Data warehousing Components ndashBuilding a

Data warehouse ndash Mapping the Data Warehouse to a Multiprocessor Architecture ndash

DBMS Schemas for Decision Support ndash Data Extraction Cleanup and Transformation

Tools ndash Metadata ndash reporting ndash Query tools and Applications ndash Online Analytical

Processing (OLAP) ndash OLAP and Multidimensional Data Analysis

Unit II

Data Mining Data Mining Functionalities ndash Data Preprocessing ndash Data Cleaning ndash Data

Integration and Transformation ndash Data Reduction ndash Data Discretization and Concept

Hierarchy Generation

Unit III

Association Rule Mining Efficient and Scalable Frequent Item set Mining Methods ndash

Mining Various Kinds of Association Rules ndash Association Mining to Correlation

Analysis ndash Constraint-Based Association Mining

35

Unit IV

Classification and Prediction Issues Regarding Classification and Prediction ndash

Classification by Decision Tree Introduction ndash Bayesian Classification ndash Rule Based

Classification ndash Classification by Back propagation ndash Support Vector Machines ndash

Associative Classification ndash Lazy Learners ndash Other Classification Methods ndash Prediction ndash

Accuracy and Error Measures ndash Evaluating the Accuracy of a Classifier or Predictor ndash

Ensemble Methods ndash Model Section Cluster Analysis - Types of Data in Cluster

Analysis ndash A Categorization of Major Clustering Methods ndash Partitioning Methods ndash

Hierarchical methods ndash Density-Based Methods ndash Grid-Based Methods ndash Model-Based

Clustering Methods ndash Clustering High-Dimensional Data ndash Constraint-Based Cluster

Analysis ndash Outlier Analysis Mining Object Spatial Multimedia Text and Web Data

Multidimensional Analysis and Descriptive Mining of Complex Data Objects ndash Spatial

Data Mining ndash Multimedia Data Mining ndash Text Mining ndash Mining the World Wide Web

Unit V

Microarray Data Mining Practical Factors Prior to Data Mining Differential Gene

Expression Discriminant Analysis Gene Annotation and Pathway Analysis Microarray

Data Mining Applications

Unit VI

Integrative Data Analysis for Biological Discovery Introduction Representative

Selection of Algorithms Application to a specific domain Future trends

Reference Books

1 Jiawei Han and Micheline Kamber ldquoData Mining Concepts and Techniquesrdquo

Second Edition Elsevier Reprinted 2008

2 Alex Berson and Stephen J Smith ldquoData Warehousing Data Mining amp OLAPrdquo

Tata McGraw ndash Hill Edition Tenth Reprint 2007

3 KP Soman Shyam Diwakar and V Ajay ldquoInsight into Data mining Theory and

Practicerdquo Easter Economy Edition Prentice Hall of India 2006

4 G K Gupta ldquoIntroduction to Data Mining with Case Studiesrdquo Easter Economy

36

Edition Prentice Hall of India 2006

5 Pang-Ning Tan Michael Steinbach and Vipin Kumar ldquoIntroduction to Data

Miningrdquo Pearson Education 2007

BT-6523 Genomics From Human Genome Project to Medical

Applications

Unit I

Biotechnology and Genomics in Medicine Gene Medicine Disease Models Impact of

Genomics on Medicine Molecular Medicines

Unit II

Genomics Human Genome Project Breakthroughs Functional Genomics Comparative

Genomics Transcriptomics Proteomics Mutational Genomics

Unit III

Genomics Applications in Infectious Diseases Identification of causative microbes

molecular epidemiology host resistance to infection pathogenicity combating infectious

diseases

Unit IV

Genomics Applications in Genetic Diseases Genetic Disorders detection and treatment

of single gene disorders analysis of polygenic disorders linkage analysis Linkage

disequilibrium mapping haplotypes MHC pharmacogenomics

Unit V

Genomics Applications in Cancer Molecular basis of cancer impact of genomics on

cancer research methods for the diagnosis of cancer approaches to cancer therapy

37

Unit VI

Case Study Cardiovascular Disorders Cardiovascular Single Gene Disorders

Cardiovascular Polygenic Disorders Therapies and Applications

Reference Books

1 Human Molecular Genetics Third Edition (2003) T Strachan and AP Read

Garland Science Publication

2 Molecular Cell Biology Sixth Edition (2007) H Lodish A Berk and CA

Kaiser W H Freeman amp Co Ltd

3 Cardiovascular Genetics and Genomics for the Cardiologist (2007) Victor J Dzau

and Choong-Chin Liew Blackwell Publishing

4 Genomics The Science of Technology Behind the Human Genome Project

(1999) Charles R Cantor and Cassandra L Smith John Wiley amp Sons Inc

5 A Century of Mendelism in Human Genetics (2005) Milo Keynes

AWFEdwards and Robert Peel CRC Press

BT-653 Professional Elective-III Laboratory

BT-6531 Computer-Aided Drug Design Laboratory

1 To perform the homology modeling of a protein by using the MODELLER

software

2 To evaluate the 3D structure of a protein by using the different tools on the SAVS

server

3 To find the active sitecavity in a receptor by using the SURFACE RACER

program

4 To draw the chemical structures by using the ChemSketchChemDraw software

5 To perform the de novo Drug Designing by using the LIGBUILDER software

6 To perform the protein-ligand docking by using the HEX program

7 To perform the protein-protein docking by using the AUTOCOCK software

38

8 To perform the virtual screening of ligands by using the DOCK program

9 To perform the Quantitative Structure-Activity Relationship (QSAR) analysis by

using the DRAGON software

10 To perform the Pharmacophore modeling of ligands by using the LigandScout

program

BT-6532 Computer Graphics Laboratory

1 Standard functions in the c graphics module -Introduction to pixels drawing

various geometric objects filling polygons images etc

2 Implementation of the basic line drawing algorithm and the Circle drawing

algorithm using DDA Midpoint algorithm Bresenhams algorithm etc

3 Polygon filling using seed fill scan line algorithm etc

4 Clipping algorithms -Cohen-Sutherland algorithm LiangBarsky algorithm etc

5 2D and 3D Transformations -Translation scaling rotation etc

6 Projections - Parallel and perspective projections and their types Curve fitting -

Cubic curves (Bezier curves spline curves etc)

7 Lighting and Shading -Implementing Phong illumination model Gouraud and

Phong shading Animation

8 Image processing demonstration

BT-6533 Pharmacogenomics and Personalized Medicine

Laboratory

1 Accessing querying and becoming comfortable with the interface of

pharmacogenomics based databases ndash

a UCSC

b NCBI dbSNP

c HapMap and resequencing databases

d 1000 Genomes

39

e PharmGKB - a publicly available Internet tool to aid researchers in

understanding how genetic variation among individuals contributes to

differences in reactions to drugs

f Drug Bank

2 Use of PGx pipeline 10 Server

3 Statistical data management using SAS

a Data Collection and Entry

b Data Storage and Transferal

c Data Analysis

d Data Exposition USING sas

4 Understand and run Warfarin dosing algorithm using web based interfaces

5 Sequence variation analysis

BT-654 Minor Project-I

BT-701 Professional Elective V

BT-7011 Immunoinformatics

Unit I

Immunology Introduction Overview of the Immune System A Case Study

Classification of Immunity Concepts in Immunology Antigens Antibodies The

Compliment System Antigen-Antibody Reactions The Major Histocompatibility

Complex allele selection Antigen Presentation TAP T cell receptors

Unit II

Advanced Immunology Immune Effector Mechanisms Cytokines and Chemokines

Hypersensitive Reactions The Immune system in Health and Disease Autoimmunity

Transplantation Immunology Classification of Vaccine

40

Unit III

HLA System in model organism Defining HLA Supertypes in HLAndashStructural and

Modeling Principles HLA Super types by GRIDCPCA and Hierarchical Clustering

Methods Structural Basis for HLA-A2 Supertypes Clustering of MHC Peptide-Binding

Repertoires HLA Alleles-Electrostatic Distribution Maps

Unit IV

In Silico Prediction of Immunogenicity Databases Searching An Introduction

MHCDB(NCBI) IMGT The IMGTHLA Database IPD The Immuno Polymorphism

Database SYFPEITHI Database for Searching and T-Cell Epitope Prediction Mapping

of T-Cell Epitopes MHC Binders and TAP Binders Mapping of LinearB-Cell Epitopes

in Bcipep Database Haptens Carrier Proteins and Anti-Hapten Antibodies

Unit V

Predictions Predicting Peptide-MHC Binding PeptidendashMHC Binding Using Profiles

Machine Learning Techniques for MHC Binders Artificial Intelligence Methods for

Predicting T-Cell Epitopes MHC-Class I and II Binding Affinity MHCndash Molecular

Affinity and QSAR Models Support Vector Machine for MHC-Binding Peptides Static

Energy Analysis of MHC Class I and Class II Peptide-Binding Affinity Nonlinear

Predictive Modeling of MHC Class IIndashPeptide Binding Using Bayesian Neural

Networks

Unit VI

Applications Computational vaccinology Viral Bioinformatics Immunogenomics

Mathematical models of HIV and the immune systems

Reference Books

1 Immunology Richard A Goldsby Thomas J Kindt Barbara A Osborne Janis

Kuby WH Freeman amp Company 5th edition Pages 19-504 2003

41

2 Roittrsquos Essential Immunology Ivan M Roitt Peter J Delves Blackwell Science

Ltd 10th Edition 2001

3 Immunoinformatics predicting Immunogenicity in-silico Darren R Flower

Humana Press Pages 1-309

4 Instant Notes in Immunology PM Lydyard A Whelan MW Fanger BIOS

Scientific Publishers Ltd 1st Edition 2003

5 An Introduction to Immunology CV Rao Narosa Publishing House1st Edition

2004

BT-7012 Medical Bioinformatics

Unit I

An Overview Introduction Problems in health care motivating biomedical informatics

Seminal documents and reports Resources of field - organizations information

education

Biomedical Computing Types of Computers Data Storage in Computers Computer

Hardware and Software Computer Networks Software Engineering Challenges for

Biomedical Computing

Electronic Health Records Clinical Data and Workflow History and Perspective of the

Health (Medical) Record Potential Benefits of the Electronic Health Record

Definitions and Key Attributes of the EHR EHR Examples Nursing Informatics

Unit II

Clinical Decision Support EHR Implementation Historical Perspectives and

Approaches Medical Errors and Patient Safety Reminders and Alerts Computerized

Provider Order Entry (CPOE) Implementing the EHR Use and Outcomes of the EHR

Cost-Benefit of the EHR

Standards and Interoperability Privacy Confidentiality and Security Standards

Basic Concepts Identifier and Transaction Standards Message Exchange Standards

42

Terminology Standards Privacy Confidentiality and Security Basic Concepts HIPAA

and Other Countriesrsquo Privacy and Security Regulations

Unit III

Secondary Use of Clinical Data Personal Health Records Health Info Exchange

Public Health Health Care Quality Clinical Research Personal Health Records Health

Information Exchange Public Health Informatics Health Care Quality Clinical Research

Informatics

Unit IV

Evidence-Based Medicine and Medical Decision Making Definitions and Application

of EBM Interventions Diagnosis Harm and Prognosis Summarizing Evidence Putting

Evidence into Practice Limitations of EBM

Unit V

Information Retrieval and Digital Libraries Information Retrieval Knowledge-based

Information Content Indexing Retrieval Evaluation Digital Libraries

Imaging Informatics and Telemedicine Imaging in Health Care Modalities of

Imaging Digital Imaging Telemedicine Definitions and Barriers Efficacy of

Telemedicine

Unit VI

Translational Bioinformatics Translational Bioinformatics - The Big Picture

Overview of Basic Molecular Biology Important Biotechnologies Driving

Bioinformatics Genetics-Related Diseases Bioinformatics Information Resources

Translational Bioinformatics Challenges and Opportunities

Organizational and Management Issues in Informatics Organizational Behavior

Organizational Issues in Failure and Success of Informatics Projects Change

Management

43

Reference Books

1 Handbook of Medical Informatics Jvan Bemmel (Editor) MA Musen (Editor)

Mark Musen (Author) Springer-Verlag published

2 Clinical Decision Support Systems Theory and Practice (Health Informatics) by

Eta S Berner (Editor) M J Ball (Editor) Springer-Verlag New York Inc

3 Computer-Based Patient Record An Essential Technology for Health Care

Revised Edition by Committee on Improving the Patient Record Institute of

Medicine Richard S Dick and Elaine B Steen (Paperback - Jan 1997)

BT-7013 Advanced Genetic Engineering

Unit I

Core techniques in gene manipulation Cutting and joining DNA introduction of DNA

into cells Isolation sequencing and synthesis of gene

Unit II

Cloning strategies construction of genomic libraries and cDNA libraries Probe

construction recombinant selection and screening Analysis of expression Analysis of

recombinant DNA site-directed mutagenesis altered expression and engineering genes

Unit III

DNA amplification using polymerase chain reaction Key concepts Analysis of amplified

products Applications of PCR Ligase chain reaction Expression systems and their

applications Ecoli Streptomyces Yeast Baculovirus and animal cells as cloning hosts

Sequencing methods

Unit IV

Transfection techniques Gene silencing techniques Gene knockouts and gene therapy

Differential gene expression and protein array Protein-protein interactions DNA-Protein

44

interactions Somatic and germ line therapy-in vivo and ex vivo Transgenics

Unit V

Applications of Genetic Engineering Pharming Genetically Engineered Foods

Biofuels Designer Babies

Unit VI

Applications of Bioinformatics in Genetic Engineering Functional Genomics

Analysis of Mutations Applications in Agriculture

Reference Books

1 Principles of gene manipulation by RNOld amp SBPrimrose (1994) Blackwell

Scientific Publications

2 DNA cloning I amp II by DM Glover amp BD Hames (1995) IRL Press

3 PCR stratagies by MA Innis DHGelfand amp JJ Sninskey (1995) Academic Press

4 Concepts in Biotechnology ndash Editors DBalasubramanian et al University Press

(1996)

5 Methods in Molecular Biology vol62 Edited by RSTuan Humana Press

Totowa New Jersey

BT-702 Professional Elective VI

BT-7021 Nanotechnology in Health Care

Unit I

Nanotechnology in Pharmaceutical Applications Human anatomy ndash Form function

and physiology ndash Developmental prolog - principle of development ndash Neurophysiology ndash

sensory physiology and muscle physiology - Trends in nanobiotechnology - Protein- and

45

peptide-based compounds for cancer diabetes infectious diseases and organ transplant-

therapeutic classes- focused pharmaceutical delivery systems

Unit II

Immunoassay Techniques Understanding of antibody-based diagnostic techniques

(immunoassay) - micro- and nano-immunosensors- Bio-Barcode Assay- use of magnets

gold DNA and antibodies- therapies and diagnostics for cancer and central nervous

system disorders

Unit III

Improved Medical Diagnostics Improved diagnostic products and techniques- in vivo

imaging capabilities by enabling the detection of tumors plaque genetic defects and

other disease states-ability to control or manipulate on the atomic scale- Nanobot medical

devices- logic and intelligence embedded into medical devices- standalone sensing and

computing devices

Unit IV

Prosthetic and Medical Plants New generations of prosthetic and medical implants-

artificial organs and implants- artificial scaffolds or biosynthetic coatings-

biocompatibility and reduced rejection ratio- retinal cochlear and neural implants

repair of damaged nerve cells and replacements of damaged skin tissue or bone

Unit V

Methods for Diagnosis Animation of the PCR - DNA Profiling - Cantilever Sensors -

Targeted Drug Delivery - Magnetic Nanoparticles - Cancer cell targeting - Stem Cell

Scaffolds - Electrochemical Impedance Spectroscopy (EIS) - Tethered Lipid Membranes

Reference Books

1 Chemical Sensors and Biosensors Brian R Eggins Wiley New York

Chichester 2002

46

2 Biosensors and modern biospecific analytical techniques Wilson amp Wilsonrsquos

Comprehensive Analytical Chemistry Ed L Gorton Elsevier Amsterdam

London 2005

3 The Immunoassay Handbook Ed David Wild 3rd ed Amsterdam Elsevier

2005

4 Electrochemical Methods Fundamentals and Applications Allen J Bard and

Larry R Faulkner Wiley New York Chichester 2nd ed 2001

5 Ultrathin Electrochemical Chemo- and Biosensors Technology and Performance

in Springer Series on Chemical Sensors and Biosensors Volume Two Ed

Vladimir M Mirsky Springer Berlin 2004

BT-7022 Resource Planning amp Management in Bioinformatics

Unit I

Introduction Fundamentals of Resource management practice

Unit II

Bioinformatics resources-an Introduction Tour to bioinformatics web sites Biological

databases and software an overview Open source movement Bioinformatics Resource

utilization and commercialization Networking and Super Computing resources- world

wide and India specific facilities Clinical applications of bioinformatics

Bioinformatics resource management the key-issues (piracy hacking and data mining)

Data Security and integration in Pharma Industry tools and techniques

Unit III

Bioinformatics Resources as a business practice The bioinformatics market-

Bioinformatics companies and products commercialization of bioinformaticsrsquo resources

funding agencies for bioinformatics projects models of technology transfer amp licensing

47

Unit IV

Commercial amp Financial aspects of Bioinformatics Concepts of software product

Market and process economics Financial appraisal of bioinformatics projects - cash flow

diagram ROR discounted ROR etc Architecture of a typical bioinformatics business

plan

Unit V

TRIPS agreement IPR issues in relation to software products processes Architecture

of Patent application Biotechnology amp Bioinformatics Related issues of Public Concern -

Bioethics

Reference Books

1 ERP Demystified Alexis Leon Tata McGraw Hill 1999

2 Concepts in Enterprise Resource Planning Joseph A Brady Ellen F Monk Bret

J Wangner Thomson Learning 2001

3 BAREACT Indian Patent Act 1970 Acts amp Rules Universal Law Publishing

Co Pvt Ltd 2007

4 Kankanala C Genetic Patent Law amp Strategy 1st Edition Manupatra

Information Solution Pvt Ltd 2007

5 Essentials of Management by H Koontz H Weihrich and C OrsquoDonnell

Publisher McGraw-HillIrwin

6 The Practice of Management by P Drucker Publisher Harper Business

BT-7023 Advanced Drug Delivery Systems

Unit I

Dendrimers- Synthesis -Nanoscale containers- Gene transfection ndash Nanosca foldsystems-

Biocompatibility of Dendromers

Unit II

Microfabricated drug delivery systems ndash Microneedles- Micropumps-Microvalves-

48

Implantable microchips ndash sustained chronic disease

Unit III

Properties of drug targeting delivery systems-ADME hypothesis- site specific drugs-

Synthetic carrier for drugs-liposomes-Antibodies

Unit IV

Targeted Nanoparticles for drug delivery- Polymers nanotubes- Issues for specific disease

will be addressed

Unit V

Virus Based Nanoparticles - Modification by bioconjugation ndash Tumour targetting invivo

ndash use in biomedical Imaging

Reference Books

1 Drug Delivery Engineering Principles for Drug Therapy M Salzman Oxford

University Press 2001

2 Drug Delivery and Targeting AM Hillery CRC Press 2002

3 Drug Delivery Principles and Applications B Wang Wiley Intersceince 2005

BT-703 Minor Project ndash II

BT-704 Major Project - I

BT-705 Self Study

BT-801 Major Project-II

1

Delhi Technological University

Civil Engineering Department

M Tech Syllabus

Various Courses of M Tech (Structure) Programmes in Delhi Technological University

Scheme for M Tech (Structural Engineering) Sem Gp Course Details Course

Code L T P Internal

Marks External Marks

Total Marks

Credits

Ist A Advanced Mathematics amp Numerical Techniques

CE501 3 0 0 50 100 150 3

Finite Element Method of Structural Analysis

CE503 3 0 0 50 100 150 3

Advanced Theory of Structures CE502 3 0 0 50 100 150 3 Structural Engg Laboratory CE504 0 0 2 30 70 100 2

B Theory of Plates amp Elastic Stability CE551 3 0 0 50 100 150 3 Theory of Elasticity amp Plasticity CE552 3 0 0 50 100 150 3 CADD Laboratory CE553 0 0 2 30 70 100 2 Self study Open Area Seminar CE554 0 0 2 50 00 50 1

21Hoursweek 1000 20 IInd C

Structural Dynamics CE601

3 0 0 50 100 150 3

Elective I any one of the following 1 Material Science amp Technology 2 Plastic Analysis of Metallic Styructures 3 Stress Analysis

CE6021 CE6022

CE6023

3 0 0 50 100 150 3

Elective II any one of the following 1 Design of Industrial Structures and

Bridges 2 Design of Tall Buildings 3 Seismic Design of Structures

CE6031

CE6032 CE6033

3 0 0 50 100 150 3

Photo-Elasticity Lab CE564 0 0 2 30 70 100 2 D Elective III any one of the following

1 Design of Structures for Dynamic Loads

2 Prestressed Concrete Design 3 Shells and Folded Plates

CE6511

CE6512 CE6513

3 0 0 50 100 150 3

Elective IV any one of the following 1 Design of Hydraulic Structures 2 Groundwater and Seepage 3 Instrumentation 4 Planning and Design of

Environmental Services

CE6521 CE6522 CE6523 CE6524

3 0 0 50 100 150 3

Str Dynamics Lab CE653 0 0 2 30 70 100 2 Minor Project I CE654 0 0 2 50 00 50 1

21Hoursweek 1000 20 IIIrd E Elective V any one of the following

1 Geotechnical Earthquake Engineering

2 Foundation Engineering 3 Soil Structure Interaction

CE7011

CE7012 CE7013

3 0 0 50 100 150 3

Elective VI any one of the following 1 Advanced Building Construction and

CE7021

3 0 0 50 100 150 3

2

Management 2 Disaster Resistant Structures 3 Soil Dynamics and Geotechnical

Earthquake Engineering

CE7022 CE7023

Self Study open area seminar II CE703 0 0 2 50 00 50 1 Minor Project II CE704 0 0 4 00 200 200 4 Major Project part I CE705 0 0 2 200 00 200 4

18Hoursweek 750 15 IVth F Major Project Part II CE801 3 0 0 00 750 750 15 6Hrswk 750 15 Grand Total 3500 70

Subject Code Subject L T P D MM

CE501 ADVANCED MATHEMATICS AND NUMERICAL TECHNIQUES

3 0 0 0

ADVANCED MATHEMATICS AND NUMERICAL TECHNIQUES Determinants and matrices Solution of linear equations Indeterminacy of structures Influence co-efficient methods Flexibility and Stiffness matrices for statically indeterminate structures Application of Fourier series to beams Complex variables Conformal mapping and Schwartz-Christoffel transformation applied to flow problems Tensor analysis (Cartesian) and its application to simple elastic and plastic problems Differential equations Series solution Bessel functions Legendre Polynomials Partial Differential equations Legendrersquos form Numerical method Finite Differences Numerical integration and differentiation Numerical solution of ordinary differential equations and their application to engineering structures Poissonrsquos Laplacersquos and biharmonic equations Relaxation methods and their application to Civil Engineering problems Advanced Computer programming and its application to Engineering problems

References

BSGrawalrdquo Higher engineering mathematicsrdquo

Jain and lyengar ldquoAdvanced engineering mathematicsrdquo Narosa publishing house

EKreyszig ldquoAdvanced engineering mathematicsrdquo John Wiley amp Sons

Peter OrsquoNeil ldquoAdvanced engineering mathematicsrdquo

Subject Code Subject L T P D MM

CE503 FINITE ELEMENT METHOD OF STRUCTURAL ANALYSIS

3 0 0 0

FINITE ELEMENT METHOD OF STRUCTURAL ANALYSIS

Finite element displacement approach plane stress and plane strain problems Triangular and rectangular elements 2-D and 3-D elements Iso-parametric elements Application to structural problems References

CSKrishnamoorthy Finite element analysis theory and programming Tata McGraw Hill Cook RD Malkus DS and Plesha ME Concepts and Applications of Finite Element Analysis Third Edition John Wiley 1989 OC Zienkiewicz The Finite Element Method McGraw-Hill

KJBathe rdquo Finite Element procedures in Engineering Analysisrdquo Prantice Hall India

3

Abel amp DesairdquoIntroduction to the Finite Element Methodrdquo CBS Publishers

Subject Code Subject L T P D MM

CE502 ADVANCED THEORY OF STRUCTURES 3 0 0 0

ADVANCED THEORY OF STRUCTURES

Flexibility and stiffness methods of structural analysis Analysis using substructure technique effects of axial forces on flexural stiffness Analysis of framed shear wall buildings Non Linear and Elasto-Plastic Analysis Beams curved in plan and elevation Various types of structural systems for tall buildings References

HCMartin Introduction to Matrix Methods of Structural Analysis

Kardestuncer Elementary Matrix Analysis of Structures

Weaver amp Gere Matrix Structural Analysis CBS Publisher

AGahali AM Neville amp Brown ldquoStructural analysisrdquo

Norris Wilbur Utku ldquo Elementry Structural analysisrdquo

BeaufaitRowanHoadley ldquoComputer method of Structural analysis

Subject Code Subject L T P D MM

CE504 STRUCTURAL ENGINEERING LABORATOR 0 0 2 0

Structural Engineering Laboratory

Concrete mix design amp testing Non destructive testing of Concrete testing of RCC Under and Over reinforced Beams Columns under eccentric loading two way reinforced RCC Slabs fracture characteristics of mild steel and cold worked steels

Subject Code Subject L T P D MM

CE551 THEORY OF PLATES AND ELASTIC

STABILITY

3 0 0 0

THEORY OF PLATES AND ELASTIC STABILITY Theory of stability The concept of stability Post buckling behaviour of long slender columns Columns with elastically supported ends Newmarkrsquos formula Columns with spring supports two hinged and fixed portal frames symmetrically loaded Energy and numerical methods of columns Columns with lateral loads Columns with variable sections Effect of shearing force on critical load Inelastic buckling of bars built up columns of varying moments of inertia Lateral buckling of beams

Buckling of Plates Theory of plates Elastic theory of plates rectangular plates with various loading and edge conditions Fourierrsquos series finite differences energy and finite element methods exact theory of plates Circular plates continues plates and approximate methods of analysing rectangular grids Distribution of concentrated loads to the various beams in grid floor and bridge decks

References

SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959

4

K Chandrashekhara Theory of Plates University Press 2001

ACStress in plates and shells

SP Timoshenko JMGere Theory of elastic stability McGraw-Hill 1959

Subject Code Subject L T P D MM

CE552 THEORY OF ELASTICITY AND PLASTICITY

3 0 0 0

THEORY OF ELASTICITY AND PLASTICITY Theory of elasticity Stress tensor equations of equilibrium Kinematic relationships and equations of compatibility Generalised Hookrsquos law Boundary conditions Plane stress and Plane strain Airyrsquos stress function Saint Venantrsquos principal problems in rectangular and polar co-ordinates

Inverse and semi-inverse methods Torsion of prismatic bars Membrane analogy Typical applications

Theory of PlasticityHydro-static and deviatorinc components of stress tensor invariants of stress tensor Tresca-Saint Venants and Henky-von Mises yield conditions Octahedral stresses

Analysis of (I) Bending of bars of narrow rectangular cross section formation of plastic hinge

(II) Torsion of prismatic bars sand heap analogy

(III) Thick Spherical shell- bursting pressure

(IV) Thick cylindrical tube autofrettage

References

SPTimoshenko amp JNGoodier Theory of Elasticity McGraw Hill-1970

MKachanov Theory of Plasticity MIR Publication

CRCalladine Plasticity for Engineers Ellis Horwood Chichester UK 1985

Subject Code Subject L T P D MM

CE553 CADD Laboratory 0 0 2 0

CADD Laboratory

Introduction to computer aided design and drafting Soil structure interaction FEM modelling application to structural engineering problems of Multistoried Buildings Bridges Water Tanks suspension Bridges using commercial softwares such as STAAD-Pro E-TabsSAP NISHA MATLAB Earthquake resistant design and drawing detailing based on IS18932002 IS43261993IS4562000 drawing detailing using AUTOCAD and solid works

Subject Code Subject L T P D MM

CE601 STRUCTURAL DYNAMICS 3 0 0 0

Structural Dynamics

5

Oscillatory motion harmonic motion periodic motion vibration terminology Characteristics of a Dynamic Problem Prescribed Dynamic Loading Definition of Dynamic DOFs Mathematical modeling of dynamic systems Formulation of Equations of motion in Generalized SDOF SDOF MDOF discrete and continuous systems using drsquoAlembertrsquos Principle Principle of Virtual displacements and Variational Approach

Free vibration equations of motion-natural frequency Experimental determination of natural frequencies viscously damped free vibration Coulomb damping Response of SDOF system to harmonic periodic impulsive and general dynamic loading earthquake excitations in time and frequency domain Base excited systems Transmissibility and Vibration isolation Laplace transform formulation energy dissipated by damping equivalent viscous damping structural damping vibration measuring instruments

Free Vibration response of discrete MDOF systems eigen values eigen vectors Approximate methods for obtaining natural frequencies and mode shapes Forced Harmonic Vibration vibration absorber vibration damper Damping in structures

Free and Forced vibration of continuous systems

Concept of Spectral quantities response spectrum Discussion on IS 1893 part I 2000 codal provisions Response of linearly elastic systems using modal analysis

References

WTThomson Theory of Vibration with Applications Pearson Education

RW Clough amp JPenzien ldquoDynamics of Structures McGraw Hill

JLHumar ldquo Dynamics of Structurerdquo Prantice Hall

JW Smith ldquo Structural Dynamicsrdquo

AK Chopra ldquoDynamics of Structures Theory and Application to Earthquake Engineeringrdquo Prantice Hall India

Mario Paz ldquo Structural Dynamics theory and Computationsrdquo CBS Publishers

Roy L Craig ldquo Structural dynamics Introduction to Computational methodsrdquo John Wiley

Meiroritch ldquoFundamentals of variablerdquo Mc Graw Hall

Jaikrashna ldquo Element of earthquake enggrdquo South asia publishers pvt Ltd

Hurty and Rubinsion ldquoDynamics of structuresrdquo PHI

Subject Code Subject L T P D MM

CE6022 PLASTIC ANALYSIS OF METALLIC STRUCTURES (Design and Viva)

0 0 0 6

PLASTIC ANALYSIS OF METALLIC STRUCTURES (Design and Viva) Moment of resistance shape factor criteria of plastic analysis comparison of elastic and plastic analysis Moment-curvature relationships for beams Plastic hinges Redistribution of moments Analysis of indeterminate beams and frames for ultimate load by the statical method and mechanism methods Load interaction method Approximate method of finding ultimate load Uniqueness theorems Limit theorems-Upper and lower bound theorems Factors affecting the full plastic moments Influence of axial force and shear Estimation of deflections at ultimate load Local and letral buckling Design of connections Minimum weight design Shake down analysis

Limit state design of structures

References

6

Baker and Heyman ldquoPlastic design of framesrdquo volIampII

Subject Code Subject L T P D MM

CE6023 STRESS ANALYSIS 3 0 0 0

STRESS ANALYSIS Full field analysis by photoelasticity laser interferometry and moireacute techniques Method of brittle coating Use of micro-processors for stress analysis

References Dally ldquoExperimental stress analysisrdquo McGrawHill

Subject Code Subject L T P D MM

CE6021 MATERIAL SCIENCE AND TECHNOLOGY

3 0 0 0

MATERIAL SCIENCE AND TECHNOLOGY Material Technology Cements-properties Aggregates Admixtures Properties of fresh and hardened concrete Mixing compacting transporting and curing of concrete Non-destructive testing special types of concrete Temperature control in mass concrete Creep and Shrinkage phenomenon in concrete Mix design Behaviour of concrete combined stresses Tests in cement aggregates and concrete Material Science Structure of materials Bonding Phase equilibrium Mechanical properties Theories of failure for combined static creep and fatigue effects Brittle and ductile fracture Plastic deformations Structural imperfections and dislocations Strain hardening Electric and magnetic properties of materials Corrosion of materials and their prevention

References

Smith ldquoPrincipal of material science and enggrdquo

Nevilly ldquoconcrete technologyrdquo

ubject Code Subject L T P D MM

CE6031

DESIGN OF INDUSTRIAL STRUCTURE AND BRIDGE

0 0 0 6

DESIGN OF INDUSTRIAL STRUCTURE AND BRIDGE (Design and Viva)

(a) Design and analysis of multi storeyed framed structures (b) Design of liquid retaining structures

(c) Design and analysis of chimneys Design of Bridges IRC codal provisions strut and tie model Load path analysis

References

NKRaju Design of bridges Oxford amp IBH Publishing Co pvt ltd

DJVictor Essentials of bridge engineering Oxford amp IBH Publishing Co pvt ltd

7

Indian Road Congress Codes No56182124 Jamnagar House Shah Jahan Road New Delhi

SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959

OP Jain ampJaikrishna ldquoPlain and reinforced concreterdquo Nemchandamp brothers

Subject Code Subject L T P D MM

CE6032

Design of tall buildings 3 0 0 0

Design of tall buildings

1 Design Criteria

Design philosophy loading sequential loading materials- high performance concrete- fiber reinforced concrete- light weight concrete- design mixes

2 Loading and Movement

Gravity loading dead and live load method of live load reduction impact gravity loading construction loads

Wind loading static and dynamic approach analytical and wind tunnel experimental method

Earthquake loading Equivalent lateral force model analysis combination of loading working stress design limit state design plastic design

3 Behaviour of various structural systems

Factor affecting growth height and structural form high rise behavior rigid frames braced frames infilled frames shear walls coupled shear walls walls-frames tubular- braced and hybrid mega system

4 Analysis and Design

Modeling for approximate analysis accurate analysis and reduction techniques analysis of building as total structural system considering overall integrity and major sub system interaction analysis for member forces drift and twist computerized general three dimensional analysis

Structural elements sectional shapes properties and resisting capacity design deflection cracking prestressing shear flow design for deferential movement creep and shrinkage effects temperature effect and fire

5 Stability of tall buildings

Overall buckling analysis of frames wall-frames approximate methods second order effects of gravity of loadingP-Delta analysis translational torsional instability out of plum effects stiffness of member in stability effect of foundation rotation

References

Bungale STaranath ldquoStructure Analysis amp Design of Tall Buildingsrdquo Mcgraw Hill Book Company Newyork 1999

Mark Fintel ldquoHandbook of concrete enggrdquo CBS

Council of tall building ldquoAdvances in tall buildingrdquo CBS

Subject Code Subject L T P D MM

CE6033 Seismic Design of Structures 3 0 0 0

8

Seismic Design of Structures

1 INTRODUCTION Elements of engineering Seismology - Theory of Vibration - Response Spectrum

2 HISTORICAL Indian Seismicity-Earthquake history - Behaviour of structures in the past Earthquakes

3 DESIGN CONCEPTS Seismic Design Concepts ndash Cyclic load Behavior of RC Steel amp Prestressed Concrete Element - Design Spectrum ndash Principles of Capacity Design

4 CODAL PROVISIONS Provisions of Seismic Code (IS 1893IS4326) ndash Building systems Frames Shear Walls Braced frames Combinations- Torsion

5 DESIGN amp DETAILING Performance of Regular Buildings 3D Computer Analysis of Building Systems (Theory Only) ndash Design amp Detailing of frames ndash Shear Walls ndashFrame walls

6 SPECIAL PROBLEMS amp CASE STUDIES Structural Configuration ndash Seismic performance- Irregular Buildings- Soil Performance-Modern Concepts ndash Base Isolation ndash Adoptive System ndash Case Studies

References

1 Course Notes ldquoDesign of Reinforced Concrete Building IIT Kanpur June 1999 2 Bungale STaranath ldquoStructure Analysis amp Design of Tall Buildingsrdquo Mcgraw Hill Book Company Newyork 1999 3 Mark Fintel ldquoHandbook of concrete enggrdquo CBS

Subject Code Subject L T P D MM

CE564 Photo Elasticity Laboratory 0 0 2 0

Photo Elasticity Laboratory

Stress analysis Two and Three Dimensional Photo-elasticity

Subject Code Subject L T P D MM

CE6512 PRESTRESSED CONCRETE DESIGN 3 0 0 3

PRESTRESSED CONCRETE DESIGN (Design and Viva) Flexural strength of prestressed concrete sections shear and torsional resistance Transfer of prestress in pretensioned members Bond and transmission length Anchorage zone stresses in pot-tensioned members

Design of pre-tensioned and post-tensioned beams Statically indeterminate structures design of continuous prestressed concrete beams and prestressed portal frames

Prestressed concrete piles and sleepers

Deflection of prestressed concrete members

References

NKRaju-Pre Stressed Concrete YGuyon-Pre Stressed Concrete

9

Mitchel amp Michael ldquoPrestressed concrete structurerdquo PHI

NRajagopalan ldquoPrestressed concreterdquoNarosa publishing house

JRLibby ldquoModern prestressed concreterdquo

Subject Code Subject L T P D MM

CE6513 SHELLS AND FOLDED PLATES

3 0 0 3

SHELLS AND FOLDED PLATES (Design and Viva) Shells Membrane theory North light shells Cylindrical shells Doubly curved shells Analysis and Design

References

SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959

OP Jain ampJaikrishna ldquoPlain and reinforced concreterdquo Nemchandamp brothers

Mark Fintel ldquoHandbook of concrete enggrdquo CBS

Subject Code Subject L T P D MM

CE6511 Design of Structures for Dynamic loads 0 0 0 6

Design of Structures for Dynamic loads

1Introduction

Factors affecting design against dynamic loads- behavior of concrete steel masonry and soil under impact and cyclic loads- recap of structural dynamics with reference to SDOF MDOF and continuum systems- ductility and its importance

2 Design against Earthquakes

Earthquake characterization ndash response spectra- seismic coefficient and response spectra method of estimating loads- response of framed braced frames and shear wall buildings- design as per BIS codes of practice- ductility based design

3 Design against blast and impact

Characteristic of internal and external blast- impact and impulse loads-pressure distribution on building above ground due to external blast- underground explosion- design of buildings for blast and impact as per BIS codes of practice

4 Design against wind

Characteristic of wind- basic and design wind speeds- effect of permeability of structure- pressure coefficient- aeroelastic and aerodynamic effect- design as per BIS code of practice including Gust factor approach-tall buildings stacks and chimneys

5 Special considerations

Energy absorption capacity- ductility of material and structure- detailing for ductility-passive and active control of vibrations- new and favourable materials

References

1 buildingrdquo John Willey and sons 1991

10

2 DowlingCHrdquoBlast vibration- monitoring and controlrdquo Prentice Hall Inc Englewood cliffs 1985 3 Kolousek Net al ldquowind effect on civil engineering structuresrdquo Elsevier 1984 4 Concrete structure under the impact Bela Goschy ldquodesign of buildings to withstand abnormal loadingrdquo

Butterworths1990 5 Paulay T and priestly MNJ ldquoA seismic design of reinforced concrete and masonry and impulsive

loadingSynthesis report CEB Lousanne getmany1988

Subject Code Subject L T P D MM

CE6521 DESIGN OF HYDRAULIC STRUCTURES 3 0 0 0

DESIGN OF HYDRAULIC STRUCTURES

1 Project planning of hydraulic structure site investigation and chose of type of hydraulic structures

2 Different types of dam their design stress analysis stress concentration around openings

3 Different types of spillway and energy dissipaters their design and analysis Model analysis of hydraulic structures

4 Design of weirs and barrages and analysis

Subject Code Subject L T P D MM

CE6524 PLANNING AND DESIGN OF ENVIRONMENTAL SERVICES

3 0 0 0

PLANNING AND DESIGN OF ENVIRONMENTAL SERVICES

Planning factors Ventilation and air conditioning plumbing Design of public bathing lighting housing with environmental perspectives

References

BCPunamia ldquoenvironmental engg Part-2rdquo

SKGarg ldquoenvironmental enggrdquo

Subject Code Subject L T P D MM

CE6522 GROUND WATER AND SEEPAGE 3 0 0 0

GROUND WATER AND SEEPAGE

Darcyrsquos law General hydro-dynamic equations flow nets in isotropic and anisotropic medium

Steady and unsteady flow through confined and unconfined aquifers Schwartz-Christoffel transformation and its application for ground water flow and seepage problems Numerical Techniques for solution of ground water flow

Multiple well system partially penetrating wells image wells mutual interference of wells

Storage and exploration of ground water Design Construction and Maintainence of wells Ground water recharge and run off Water quality budgeting simulation of ground water basin Application of remote sensing for ground water

Subject Code Subject L T P D MM

11

CE6523 INSTRUMENTATION 3 0 0 0

INSTRUMENTATION

Types of applications of measurement instrumentation Generalised configurations and functional descriptions of measuring instruments Motion measurement Pressure measurement Flow measurement Environmental engineering Instrumentations

Subject Code Subject L T P D MM

CE653 Structural Dynamics Laboratory 0 0 2 0

Structural Dynamics Laboratory

Model Testing Models of Frames under Static and Dynamic Loading Free and Forced Vibration using MTS Determination dynamic Modulus Damping etc and some more experiment heavy structural engg lab

Subject Code Subject L T P D MM

CE7011 GEOTECHNICAL EARTHQUAKE ENGINEERING

3 0 0 0

GEOTECHNICAL EARTHQUAKE ENGINEERING Introduction to engineering seismology seismic risks and hazards causes and strength of earthquakes social and economic

consequences theory of dynamic and seismic response the nature and attenuation of earthquake magnitude ground motion

determination of site characteristics local geology and soil condition determination of design earthquake response spectra and

accelerograms Site response to earthquake site investigation and soil test dynamic behaviour of soils liquefaction phenomena

analysis of pore pressure development laboratory and in-situ testing for liquefaction analysis and design of slopes embankments

seismic response of soil structure system shallow foundation pile foundation foundations and earth retaining structures for

seismic loading case histories mitigation techniques

Subject Code Subject L T P D MM

CE7012 FOUNDATION ENGINEERING

3 0 0 0

FOUNDATION ENGINEERING Structures subjected to vertical and lateral loads excavation vertical cut retaining walls shallow foundation flexible and rigid rafts highway pavements allowable bearing pressure geo-technical investigation interpretation from field tests pile and cassion group action of piles pier shafts in rock socket Foundations subjected to dynamic loads theory of vibrations natural frequency of a soil foundation system Elastic constant of soils pressure bulb concept permissible amplitude various considerations for machine foundation Strength and deformation characteristics of granular media under dynamic loads Liquefaction References

BM Das Advanced Foundation Engineering Brookes and Cole India

J Bowels Foundation analysis McGrawHill Publishers

Rao NSVK Vibration analysis and foundation dynamics AH Wheeler amp Co New Delhi India

Subject Code Subject L T P D MM

12

CE7013 SOIL STRUCTURE INTERACTION 3 0 0 0

Soil Structure Interaction

1 SOIL FOUNDATION INTERACTION Introduction to soil foundation interaction problems Soil Behaviour Foundation Behaviour Interface behaviour Scope of soil foundation interaction analysis Soil response models Winkler Elastic Continuum Two parameter elastic models Elastic plastic behaviour Time dependent behaviour

2 BEAM ON ELASTIC FOUNDATION ndash SOIL MODELS Infinite beam Two Parameters Isotropic elastic half space Analysis of beams of finite length Classification of finite beams in relation to their stiffness

3 PLATE ON ELASTIC MEDIUM Infinite Plate Winkler Two parameters Isotropic elastic medium Thin amp Thick plates Analysis of finite plates rectangular amp circular plates Numerical analysis of finite plates simple solutions

4 ELASTIC ANALYSIS OF PILE Elastic analysis of single pile Theoretical solution for settlement amp Load Distributions Analysis of Pile Group Interaction Analysis Load Distribution in groups with Rigid Cap

5 LATERALLY LOADED PILE Load Deflection Prediction for Laterally loaded piles Sub-grade reaction amp Elastic analysis Interaction analysis Pile raft system Solutions through influence charts

References 1 Selva durai APS Elastic analysis of Soil Foundation Interaction Elsevier 1979 2 Poulos HG amp Davis EH Pile Foundation Analysis amp Design John Wiley 1980 3 Scott RF Foundation Analysis Prentice Hall 1981 4 Structure Soil Interaction-State of Art Report Institution of Structure Engineers 1978 5 ACI 336 Suggested Analysis and Design Procedure for Combined Footings amp Mats American Concrete Institute Delhi

1988 6 SP Timoshenko SW Krieger Theory of Plates and Shells McGraw-Hill 1959 7 SP Timoshenko Strength of material CBS Publisher 8 Bowles ldquoFoundation analysis and designrdquo McGrawHill

Subject Code Subject L T P D MM

CE7022 DISASTER RESISTANT STRUCTURES 3 0 0 0

Disaster Resistant Structures

1 BEHAVIOUR OF LIFE ndash LINE STRUCTURES Philosophy for design to resist earthquake Cyclone amp Flood-National amp International Codes of practice- By ndash Law of urban amp Semi-urban areas- Traditional amp Modern Structures

2 COMMUNITY STRUCTURES

Response of dams bridges buildings- Strengthening measures- Safety analysis and rating-Reliability assessment

3 REHABILITATION AND RETROFITTING

Testing and evaluation-Classification of structures for safety point of view- methods of strengthening for different disasters ndash qualification test

4 DETAILING OF STRUCTURES AND COMPONENTS

Use of modern materials amp their impact on disaster reduction- Use of modern analysis Design amp Construction techniques optimization for performance

5 DAMAGE ASSESSMENT OF STRUCTURES

Damage surveys- Maintenance and Modification to improve hazard resistance- Different types of Foundation amp its impact on safety- Ground improvement techniques

13

References

1 VMoskvin etall Concrete and Reinforced Concrete- Deterioration amp Protection- Mir Publishers-Moscow 1980 2 RTAllen and SCEdwards Repair of Concrete Structures Blakie and Sons UK 1987 3 3Proceedings IABSE 14th Congress ldquoCivilization through Civil Engineeringrdquo New Delhi May 1992 4 Raiker RNLearning from failure deficiencies in Design Construction and Service R amp D Centre (SDCPL) Raiker

Bhawan Bombay 1987 5 IS13827IS13828IS13935 6 ISO23941382315686 Part I to IX

Subject Code Subject L T P D MM

CE7021 ADVANCED BUILDING CONSTRUCTION AND MANAGEMENT

3 0 0 0

ADVANCED BUILDING CONSTRUCTION AND MANAGEMENT New techniques and materials of building construction Building construction management techniques

References

1 LSShrinath ldquoCPM ampPERTrdquo 2 Software PRIMAVERA-2 or above 3 Peurifoy ldquoConstruction planning equipment and methodsrdquo

Subject Code Subject L T P D MM

CE7023 Soil Dynamics and Geotechnical Earthquake Engineering

3 0 0 0

Soil Dynamics and Geotechnical Earthquake Engineering

Seismology and Earthquakes seismic hazard Analysis Engineering Problems involving Soil Dynamics Wave propagation in elastic media General nature of Soil Behaviour under cyclic dynamic loading Field and laboratory tests for measurement of small strained and large strain dynamic properties of soils

Strong Ground Motion measurement characterization and estimation Amplification Theory and Ground Response Analysis Local Site Effects and Design Ground Motions

Liquefaction Evaluation of liquefaction hazards susceptibility

Study of Initiation of liquefaction Characterization of Liquefaction resistance based on lab and in-situ tests and Evaluation of Initiation of Liquefaction

Study of effects of liquefaction

Seismic Slope Stability Seismic Design of retaining walls Soil Improvement for remediation of Seismic Hazards

References

Steven L Kramer lsquoGeotechnical Earthquake Engineeringrdquo Pearson Education

14

Scheme for M Tech (Geotechnical Engineering)

Sem Gp Course Details Course Code

L T P Intern Marks

Extern Marks

Total Marks

Credits

Ist A Advanced Soil mechanics CE521 3 0 0 50 100 150 3 Rock Mechanics CE523 3 0 0 50 100 150 3 Geotechnical Exploration CE522 3 0 0 50 100 150 3 Geotechnical Egg Lab-I CE524 0 0 2 30 70 100 2

B Advanced Foundation Engineering CE571 3 0 0 50 100 150 3 Soil Dynamics and Machine Foundations

CE572 3 0 0 50 100 150 3

Geotechnical Egg Lab-II CE573 0 0 2 30 70 100 2 Self Study open area seminar-I CE574 0 0 2 50 00 50 1

21Hoursweek 1000 20 IInd C Application of Geotechnical Engg in

Water Resources amp GIS CE621 3 0 0 50 100 150 3

Elective I any one of the following 1 Computational Geotechnics 2 Plasticity amp fracture Mechanics in

Rock Structures 3 Theoretical Soil Mechanics

CE6221 CE6222 CE6223

3 0 0 50 100 150 3

Elective II any one of the following 1 Design of Hydraulic Structures 2 Geo-environmental Engineering 3 Groundwater and Seepage

CE6231 CE6232 CE6233

3 0 0 50 100 150 3

Geotechnical Engg Lab-III CE624 0 0 2 30 70 100 2 D Elective III any one of the following

1 Excavation Technology 2 Geotechnical Earthquake

Engineering 3 Theory of Elasticity and Plasticity

CE6711 CE6712 CE6713

3 0 0 50 100 150 3

Elective IV any one of the following 1 Ground Improvement Techniques 2 Geosynthetics 3 Slope Stability Analysis

CE6721 CE6722 CE6723

3 0 0 50 100 150 3

Geotechnical Engg Lab IV CE673 0 0 2 30 70 100 2 Minor Project I CE674 0 0 2 50 00 50 1

21Hoursweek 1000 20 IIIrd E Elective V any one of the following

1 Critical State Soil Mechanics 2 Design of Sub-structures 3 Soil Structure Interaction

CE7211 CE7212 CE7213

3 0 0 50 100 150 3

Elective VI any one of the following 1 Earth Pressure amp Earth Retaining

Structures 2 Offshore Geotechnical

Engineeging 3 Unsaturated Soil Mechanics

CE7221 CE7222 CE7223

3 0 0 50 100 150 3

Self Study open area seminar II CE723 0 0 2 50 00 50 1 Minor Project II CE724 0 0 4 00 200 200 4 Major Project part I CE725 0 0 2 200 00 200 4

18Hoursweek 750 15 IVth F Major Project Part II CE821 3 0 0 00 750 750 15 6Hrsw

k 750 15

Grand Total 3500 70

15

Advanced Soil Mechanics

Paper Code L T P Cr

CE 521 3 0 0 3

Clay minerology clay-water electrolyte system soil structure and fabric Effective stress hydraulic conductivity seepage Special

soils collapsible amp sensitive clays loessic bouldary and expansive soils Consolidation one-dimensional and generalised

consolidation theories primary and secondary consolidation sand drains consolidation settlements Shear behaviour of soils pore

pressure parameters UU CUampCD tests stress path method for settlement analysis Total amp effective stress-path water content

contours stress history Anisotrppy of strength Thixotropy Creep Determination of in situ undrained shear strength stress-strain

characteristics of soilsDetermination of modulus values Critical state model

20 Rock Mechanics

Paper Code L T P Cr

CE523 3 0 0 3

Introduction problems of rock mechanics classifications of rock masses rock exploration ndash rock coring geophysical methods

laboratory testing of rocks fraction in rocks elasticity amp strength of rocks strength amp failure of rocks Griffithrsquos theory

Coulombrsquos theory in-situ tests on rock mass deformation characteristics instrumentation and measurement of deformation of

rocks permeability Mechanical thermal and electrical properties of rock mass openings in rock mass and stresses around

openings slope stability pressure tunnels development of plastic zone rock support needed to avoid plastic deformation lined

and unlined tunnels support pressure and slip of the joint underground excavation and subsidence foundation on rocks bearing

capacity of intact and jointed rocks rock slopes rock bolt anchors amp grouting underground openings pillars tunnels methods of

construction problems associated with tunnels tunnelling in various subsoil conditions and rocks

30 Geotechnical Exploration

Paper Code L T P Cr

CE 522 3 0 0 3

Planning of geotechnical exploration methods of boring Boring in soils and rocks methods of stabilizing the bore holes

Sampling techniques Sampling disturbances storage labeling and transportation of samples sampler design influence on

properties field tests standard penetration plate load static and dynamic cone penetration field vane shear and pressuremeter

tests electrical resistivity and seismic refraction tests location of ground water table processing of soil exploration data and its

interpretation

40 Geotechnical Engineering Lab I

Paper Code L T P Cr

CE 524 0 0 2 2

This Laboratory is based on the syllabus of CE 541 CE 542 CE 543

16

50 Advanced Foundation Engineering

Paper Code L T P Cr

CE 571 3 0 0 3

Shallow foundations subjected to static eccentric and inclined loads bearing capacity analysis settlement amp allowable bearing

capacity of shallow foundation uplift capacity of shallow foundation raft foundations pile foundations-design in different soil

conditions load distribution between vertical and battered piles moment on pile foundations group effect on piles raft on piles

piers and pier shafts caisson settlement analysis of pile groups amp shafts analysis amp design of well foundation foundation on

reinforced soil

60 Soil Dynamics amp Machine Foundation

Paper Code L T P Cr

CE 572 3 0 0 3

Introduction fundamentals of vibrations vibration of elementary systems-mass spring

dashpot systems various degrees of freedom dynamic properties of geo-materials propagation of wave in granular media

laboratory and field tests for evaluation of dynamic soil properties analysis and design of foundations for hammers reciprocating

engines and turbo generators dynamic stiffness of single pile and pile groups vibration isolation and damping theories for

vibration of foundations on elastic media design procedures for foundations with dynamic load and construction features elastic

homogeneous half space solutions lumped parameter solutions large deformation problems liquefaction of soils amp cyclic

mobility

70 Geotechnical Engineering Lab II

Paper Code L T P Cr

CE 573 2 2

This Laboratory is based on the syllabus of CE 541 542 543 545 546

8 Application of Geotechnical Engg in Water Resources amp GIS

Paper Code L T P Cr

CE 621 3 -- -- 3

Selection of sites for different water resources projects Geotechnical investigations Classification of dams Causes of failure of

earth dams relative advantages and disadvantages of earth dams over gravity dam Preliminary section of earth dams Typical

section of earth dams Checking the stability of earth dams Slope stability analysis Stability of foundation of earth dams against

shear Design consideration of earth dam in seismic regions Rockfill dam impervious membrane type rockfill dam design

consideration of rockfill dam Hydroelectric power classifications and investigations Features and characteristics of hydropower

generation and Principal components of a hydropower station Design of different components like Intakes Water conductor

system Tunnels Surge tanks Penstocks Anchor blocks and their management at site

17

Introduction to GIS and remote sensing cartographic data model digital data model data source data capture and data analysis

role of remote sensing and GIS in flood disaster studies Landslides and Earthquake Various GIS packages and their salient

features

90Elective I Opt any one of the following

10 Theoretical Soil Mechanics

20 Computational Geotechnics

30 Plasticity amp Fracture Mechanics in Rock Structures

100Elective II Opt any one of the following

40 Geo-environmental Engineering

50 Ground water amp Seepage

60 Design of Hydraulic structures

110 Geotechnical Engineering Lab III

Paper Code L T P Cr

CE 624 2 2

This Laboratory is based on the syllabus of courses mentioned above

120Elective III Opt any one of the following

70 Goetechnical Earth quake Engineering

80 Theory of Elasticity and Plasticity

90 Excavation Technology

130Elective IV Opt any one of the following

100Ground Improvement Techniques

110 Geosynthetics

120 Slope Stability Analysis

140 Geotechnical Engineering Lab IV

Paper Code L T P Cr

CE 673 2 2

This Laboratory is based on the syllabus of courses mentioned above

150Elective V Opt any one of the following

130 Critical State Soil Mechanics

140 Design of Sub Structures

18

150 Soil Structure Interaction

160Elective VI Opt any one of the following

160 Unsaturated Soil Mechanics

170Flow Through Porous Media

180 Earth Pressure amp Earth Retaining Structures

SYLLABUS OF ELECTIVE COURSES

10 Theoretical Soil Mechanics

Paper Code L T P Cr

CE 6223 3

Stresses and strains elastic equilibrium analysis for plane strain and three dimensional cases Effective stresses analysis of

deformation and strain states of stress and strain consitutive relationsequilibrium and compatibilitygeneral theorems drained

and undrained loading state boundary surface plastic flow yield and hardeningfailure theorems for soils failure and plastic flow

at critical state associative and non-associative flow residual strength anisotropic compressions ideal elastic behaviour ndash two

and three dimensional systems theorems of plastic collapse and their application to soil-structure interaction elastoplastic theory

of soils rheological models nonlinear viscoelasticity problems and solutions

20 Computational Geotechnics

Paper Code L T P Cr

CE 6221 3

Introduction to numerical modeling in Geotechnical Engineering basic concepts stress deformation analysis analysis of

foundations dams underground structures and earth retaining structures Finite difference method Finite element method

Boundary element method Discrete element method Constitutive modeling use of finite element finite difference and discrete

element computer codes for solving geotechnical engineering problems Use of some of the appropriate software package like

UDEC FLAC PLAXIS etc

3 Plasticity amp Fracture Mechanics in Rock Structures

Paper Code L T P Cr

CE 6222 3

Theory of plasticity Three dimensional stress analysis stress invariants octahedral stresses Large deformationsfinite strains -

Euler amp Langragian approaches Greenrsquos amp Cauchyrsquos strain tensors Yield criteria Von Mises Tresca Mohr-Coulomb Drucker-

Prager Modified Mohr-Coloumb Hoek amp Brown yield criteria Isotropic and Kinematic hardening softening normality principle

plastic flow rule plastic potential Druckerrsquos postulates and Prandtlrsquos conditions for stability of plastically deforming bodies

Plastic Stress-Strain relations Stress path dependent behaviour Prandtl-Rauss equations Levy-Mises relations generalised

19

elasto-plastic stress-strain realtionshardening modulus Applications to problems of tunnels etc Crack phenomenon and

mechanics of brittle fracture propagation effects of crack on elasticproperties Energy theories of failure elementary theories of

crack propagation cracks in elasto-plastic media Constitutive equations for rocks ndash Class I and Class-II materials Servo

controlled testing and post failure behaviour under uniaxial and triaxial stress conditions in tension Compression and shear size

effects representative size of specimen Continum characterization of jointed rock mass Weibullrsquos thoery in tension

compression and bending for strength constitutive equations for discontinuities ndash Joint stiffnesses and shear strength Ladanyirsquos

constitutive equations Stick Slip phenomenon Application of fracture mechanics to underground opening rock stabbing bursting

and hydraulic fracturing

40 Geo Environmental Engineering

Paper Code L T P Cr

CE 6232 3

Introduction Sources of subsurface contamination Mechanisms of Soil contamination Physical-chemical and biological

interactions in soils Effect of contamination on geotechnical properties Waste disposal on land Types of landfills Siting criteria

waste containment principles Types of barrier materials Planning and design aspects relating to waste disposal in landfills in ash

ponds and tailing ponds Environmental monitoring around landfills Detection control and remediation of subsurface

contamination Various types of barrier systems Reclamation of contaminated sites Case Studies

50Ground Water and Seepage

Paper Code L T P Cr

CE 6233 3

Darcyrsquos law General hydro-dynamic equations flow nets in isotropic and anisotropic

medium Steady and unsteady flow through confined and unconfined aquifers Schwartz-Christoffel transformation and its

application for ground water flow and seepage problems Multiple well system partially penetrating wells image wells mutual

interference of wells Storage and exploration of ground water design construction and maintenance of wells ground water

recharge and run off water quality budgeting simulation of ground water basin application of remote sensing for ground water

60 Design of Hydraulic Structures

Paper Code L T P Cr

CE 6231 3

Project planning site investigations choice of type of dams cost-benefit studies Non-overflow dams gravity arch and buttress

type rock-fill and earthen dams their design stress analysis stress concentration around openings Different types of spillways

and energy dissipaters their design preparation and protection of foundation for dams model analysis of hydraulic structures

instrumentation in dams temperature control in concrete dams

70 Geotechnical Earthquake Engineering

Paper Code L T P Cr

20

CE 6712 3

Introduction to engineering seismology seismic risks and hazards causes and strength of earthquakes social and economic

consequences theory of dynamic and seismic response the nature and attenuation of earthquake magnitude ground motion

determination of site characteristics local geology and soil condition determination of design earthquake response spectra and

accelerograms Site response to earthquake site investigation and soil test dynamic behaviour of soils liquefaction phenomena

analysis of pore pressure development laboratory and in-situ testing for liquefaction analysis and design of slopes embankments

seismic response of soil structure system shallow foundation pile foundation foundations and earth retaining structures for

seismic loading case histories mitigation techniques

80 Theory of Elasticity and Plasticity

Paper Code L T P Cr

CE 6713 3 - -

Theory of Elasticity Stress tensor equations of equilibrium Kinematic relationships and equations of compatibility Generalized

Hookersquos Law Boundary conditions Plane stress plane strain Airyrsquos stress function Saint Venantrsquos principle Problems in

rectangular and polar co-ordinates inverse and semi-inverse methods torsion of Prismatic bars members analogy typical

applications Theory of plasticity hydro-static and deviatoric components of stress tensor invariant of stress tensors Tress-Saint

Venant and Honkey-Von Misses yield conditions octahedral stresses Analysis of Bending of bars of narrow rectangular

cross section-formation of Plastic hinge Torsion of prismatic bars-sand-heap analogy Thick spherical shell-bursting pressure

Thick cylindrical tube

90Excavation Technology

Paper Code L T P Cr

CE 6711 3

Construction Planning amp scheduling Importance of planning pre-planning analysis Network planning including CPM amp PERT

techniques Contract management Contractual Risks amp Risk management Excavation in soils Tractors Dozers Bull-dozers

Wheel Loaders Shovels Draglines Buckets Clampshells Scrapers Hydraulic Excavators Excations in Rocks manual

excavation tools and techniques Drilling and blasting versus Ripping Excavations of Dam Foundations Controlled drilling and

blasting Selection and matching of loading and hauling equipment Excavations of tunnels amp caverns Type of cuts and drilling

patterns Methods of Tunnel driving Excavation cycles Full face heading heading and benching Ring drilling method

Forepoling Side drift method Presplitting and smooth blasting Excavation in different ground conditions mixed face tunneling

Machine Tunneling Shield tunneling Types of TBMs new TBMs New Austrian Tunneling Method(NATM) Norweign

Tunneling Method (NTM) TBMs versus drilling and blasting TBM in different ground conditions Limitations of machine

tunneling Excavations of Shafts and Caverns Excavation with limit raiser climber Shaft boring lining segments for shield driven

tunnels Differnet stages in excavation of caverns Ventilation in Long Tunnels

100 Ground Improvement Technique

Paper Code L T P Cr

CE 6721 3

21

Ground improvement principles of ground improvement mechanical modificationproperties of compacted soil compaction

control tests hydraulic modification dewatering systems filtration drainage and seepage control with geosynthetics preloading

and vertical drains electro kinetic dewatering chemical modification modification by admixtures stabilization using industrial

wastes grouting modification by inclusion and confinement soil reinforcement flexible geosynthetic sheet reinforcement

anchorage reinforcement techniques bearing capacity improvement slope stability erosion control retaining walls and

pavements Soil stabilization shallow stabilization with additives lime flyash cement and other chemicals and bitumen deep

stabilization sand column stone column sand drains prefabricated drains electro-osmosis lime column soil-lime column

grouting permeation compaction and jet vibro-floatation dynamic compaction thermal freezing dewatering systems

110 Geosynthetics

Paper Code L T P Cr

CE 6722 3

Geosynthetics types and functions materials and manufacturing processes testing and evaluations principles of soil

reinforcement design and construction of geosynthetic reinforced soil retaining structures walls and slopes Geosynthetics in

pavements geosynthetics in roads and railways separations drainage and filtration in road pavements and railway tracks design

and construction relevant guidelines Geosynthetics in pollution control liners for ponds and canals covers and liners for

landfills material aspects and stability considerations

120 Slope Stability Analysis

Paper Code L T P Cr

CE 6723 3

Introduction Natural and man made slopes types of slope movements amp land slides nature of soil amp rock Progressive failure of

slopes Limit Equlibrium Methods Infinite and finite height slopes Planar failure surface Slip surface of arbitrary shape Natural

slope analysis considering initial stresses Sewdish method Bishoprsquos simplified methodother methodsstability chart Various

conditions of analysis factor of safety codal provisions Some special aspects of slope analysisie Earthquakes Creep

Anisotropy Probabilistic approach in slope analysis Centrifuge Model testingReinforced slopesembankment on soft soils

130 Critical State Soil Mechanics

Paper Code L T P Cr

CE 7211 3 - -

Review of stress and effective stress analysis of deformation and strain ideal elastic behavior elastoplastic behavior of soils

stress path and invariants constitutive relations drained and undrained loading isotropic compressions elastic wall state

boundary surface associative and non-associative flow yield and hardening critical state line amp Roscoe surface plastic collapse

residual strength behavior of oc clays for Hvorslev surface critical state for sand effect of dilation applications

140 Design of Sub-Structures

Paper Code L T P Cr

CE 7212 3

22

Introduction Substructure ndash Definition and purpose role of foundation engineern Basic Soil input parameters for foundation

design Foundation Design General principles Types of foundations selection of type of foundation Basic requirements

Computation of loads Limit State Design Basic principles Shallow Foundations Types and their selection Conventional

method of design Beams on elastic foundation and Finite difference method of analysis Structural design of footings and rafts

Foundations subjected to eccentric-inclined loads Footing in seismic zones Pile Foundations Type construction techniques

Proportioning of pile foundations loadsforces considered for structural design Structural design of pile foundation for a

multistoreyed buildings and other important structures Pile foundations subjected to dynamic loads Bridge Substructures _

Forces on bridge Foundation (IRC amp IS specifications) Design of piers Abutments amp wing Walls Well Foundation Components

Stability analysis Design of various components Materials for construction Sinking of well Placing of Curb Dredging and

Jetting marine Substructure Types Breakwaters Wharves Sea Walls Design and Construction Methods Foundations of

transmission line towers forces on tower foundation General design criteria Choice amp type of foundation Design Procedure

150 Soil-Structure Interaction

Paper Code L T P Cr

CE 7213 3

General soil-structure interaction problems contact pressures and soil-structure interaction for shallow foundations concept of

sub grade modulus effectsparameters influencing subgrade modulus analysis of foundations of finite rigidity beams on elastic

foundation concept introduction to the solution of beam problems Curved failure surfaces their utility and analyticalgraphical

predictions from Mohr-Coulomb envelope and circle of stresses earth pressure computations by friction circle method earth

pressure distribution on walls with limitedrestrained deformations Dubravorsquos analysis earth pressures on sheet piles braced

excavations design of supporting system of excavations arching in soils elastic and plastic analysis of stress distribution on

yielding bases Modern concept of analysis of piles and pile groups axially laterally loaded piles and groups interaction analysis

Reese and Matlockrsquos tunnelling solution elastic continuum and elasto-plastic analysis of piles and pile groups Hrennikoffrsquos

analysis ultimate lateral resistance of piles by various approaches non-linear load-deflection response uplift capacity of piles and

anchors

160 Unsaturated Soil Mechanics

Paper Code L T P Cr

CE 7223 3

Identification and classification of expansive and collapsing soils effective stress concepts matric and osmotic suction collapse

heave and strength characteristics of unsaturated soils flow through unsaturated soils laboratory evaluation of swell pressure and

swell potentialtests to evaluate collapse potential measurements of soil suction

170Offshore Geotechnical Engineeging

Paper Code L T P Cr

CE 7222 3

Submarine soilsoriginnature and distributionTerriginic and pelagicsubmarine soils of India Engineering behaviour of

submarine soilsunder consolidated soilscalcareous soilscemented soilscorals

23

Offshore site investigations sampling and sampling disturbanceinsitu testingwireline technologyoffshore pile foundations for

jacket type structuresfoundations of gravity structures

Foundations for jack-up rigsanchors and break out forcesanchor systems for floating structuresstability of submarine

slopesInstallation and stability of submarine pipelines

180 Earth Pressure amp Earth Retaining Structure

Paper Code L T P Cr

CE 7221 3

Earth pressure theories Rankines theory Coulombs theory graphical techniques amp analytical methods rigid retaining structures

types empirical methods stability analysis Flexible retaining structures types material cantilever sheet piles anchored

bulkheads ndash free earth method fixed earth method moment reduction factors anchorage Braced excavation types construction

methods pressure distribution in sands and clays stability - bottom heave seepage ground deformation Reinforced soil walls

elements construction methods external stability internal stability Arching action underground structures in soils pipes

conduits trenchless technology tunnelling techniques - cut-and-cover method shield tunnelling Stability of slopes analysis of

earth amp rock fill dam

Recommended Books-

1 The Mechanics of Soils JH Atkinson amp PL Brandsy (1982) 2 Critical State Soil Mechanics AN Schofield amp CP Wroth (1968) 3 Introduction to Rock Mechanics RE Goodman (1989) 4 Engineering in Rocks T Ramamurthy (2007) 5 Shallow Foundation BM Das (1999) 6 Foundation Analysis amp Design JE Bowles (1988) 7 Foundation Engineering G Leonards (1962) 8 Basic amp Applied Soil Mechanics G Ranjan amp ASR Rao (2006) 9 Soil Dynamics S Saran (1999) 10 Geotechnical Earthquake Engineering SL Kramer (2003) 11 Geotechnical Modelling DM Wood (2004) 12 Analysis amp Design of Substructures S Saran (1996) 13 Geotechnical Practice for Waste Disposal DE Danial (1993) 14 Ground Water DK Todd (1959) 15 Designing with Geosynthetics RM Koerner (1997) 16 Ground Water amp Seepage ME Harr (1962) 17 Ground Water amp Seepage DK Todd (1959) 18 Engineering Hydrology SS Butler (1959) 19 Ground Water its development uses and conservation EW Bennisen (1972) 20 Theory of Elasticity amp Plasticity SP Timoshenko amp JN Goodier (1982) 21 Soil Mechanics in the light of Critical State Theories JAR Ortigao (1995) 22 Design of Small Dams USBR Manual (1965) 23 Design and Construction of Dams Edward Wegwann (1978) 24 Earth and Rock Dams Sheard L James 25 Properties of Concrete AM Neville (2007) 26 The Chemistry of Cement and Concrete FM Lea (1970) 27 Soil Mechanics Principle and Practice GE Barnes (2000) 28 Advanced Soil Mechanics BM Das (1997) 29 Soil Mechanics for Unsaturated Soils DG Fredlund and H Rahardjo (1993) 30 Soil Mechanics TW Lambe and RV Whitman (1987) 31 Fundamentals of Soil Behaviour James K Mitchell (1993) 32 Principles of Soil Mechanics RF Scott (1963) Foundation Analysis and Design JE Bowles (1996) 34 Foundation Design Principles and Practices Donald P Coduto (2001)

24

35 Design Aids in Soil Mechanics and Foundation Engineering Shenbaga R Kaniraj (1988) 36 Pile Foundation Analysis and Design HG Poulus and EH Davis (1980) 37 Earth and Earth-Rock Dams JL Sherard RJ Woodward SF Giziensky and WA Clevenger (1963) 38 Soil Mechanics in Engineering Practice K Terzaghi RB Peck and G Mesri (1996) 39 Foundation Design and Construction MJ Tomlinson (1996) 40 Engineering Treatment of Soils FC Bell (1993) 41 Earth Reinforcement and Soil Structures JFP Colin (1996) 42 Foundation Engineering Handbook HY Fang (1991) 43 Engineering Principles of Ground Modification MR Hausmann (1990) 44 Ground Improvement MP Moseley (1993) 45 Ground Control and Improvement PP Xanthakos LW Abramson and DA Bruce (1994) 46 Design Construction and Monitoring of Landfills A Bagchi (1994) 47 Geoenvironmental Engineering LN Reddi and HI Inyang (2000) 48 Environmental Geotechnics R Sarsby (2000) 49 Planning Design and Analysis of Tailings Dams SG Vick (1970) 50 Earthquakes Bruce A Bolt (1999) 51 Exploration Geophysics of the Shallow Subsurface Robert H Burger (1992) 52 Principles of Soil Dynamics BM Das (1993) 53 Geotechnical Earthquake Engineering Handbook RW Day (2002) 54 Construction Vibrations CH Dowding (2000) 55 Soil Behaviour in Earthquake Geotechnics Kenji Ishihara (1996) 56 Geotechnical Earthquake Engineering SL Krammer (1996) 57 Cyclic Loading of Soils from Theory to Design MP OrsquoReilly and SF Brown (1991) 58 Foundations for Machines Analysis and Design S Prakash and V K Puri (1988) 59 Dynamic Soil Structure Interaction John P Wolf (1985) 60 Rock Engineering JA Franklin and MB Dusseaut (1989) 61 Introductory Rock Mechanics RF Goodman (1980) 62 Foundation of Theoretical Soil Mechanics ME Harr (1966) 63 Fundamentals of Rock Mechanics JC Jaeger and NGW Cook (1969) 64 Elastic Solutions for Soils and Rock Mechanics HG Poulos and EH Davis (1974) 65 Rock Mechanics in Engineering Practice KG Stagg and OC Zienkiewics 66 Numerical Methods in Geotechnical Engineering DesaiCS and Christian 67 Finite Element Procedures in Engineering Analysis BatheKJ 68 Soil Behaviour and Critical State Soil Mechanics Wood DM

25

Scheme for M Tech (Environmental Engineering)

Sem Gp Course Details Course Code

L T P Intern Marks

Extern Marks

Total Marks

Credits

Ist A Advanced Mathematics and Statistics CE-511 3 0 0 50 100 150 3 Environmental Chemistry and Microbiology

CE512 3 0 0 50 100 150 3

Water Pollution CE513 3 0 0 50 100 150 3 Microbiology Lab CE514 0 0 2 30 70 100 2

B Air Pollution amp Control CE561 3 0 0 50 100 150 3 Water Engineering Design CE562 3 0 0 50 100 150 3 Water Engineering Laboratory CE563 0 0 2 30 70 100 2 Self Study open area seminar-I CE564 0 0 2 50 00 50 1

21Hoursweek 1000 20 IInd C Wastewater Treatment Design CE611 3 0 0 50 100 150 3

Elective I any one of the following 1 Groundwater and Seepage 2 Instrumentation

CE6121 CE6122

3 0 0 50 100 150 3

Elective II any one of the following 1 Design of Hydraulic Structures 2 Industrial Wastewater Treatment

CE6131 CE6132

3 0 0 50 100 150 3

Air Pollution Laboratory CE614 0 0 2 30 70 100 2 D Elective III any one of the following

1 Global Warming and Climate Change

2 Planning and Design of Environmental Services

CE6611 CE6612

3 0 0 50 100 150 3

Elective IV any one of the following 1 Environmental Planning and

Management 2 Solid Waste Management

CE6621 CE6622

3 0 0 50 100 150 3

Solid Waste amp Industrial Wastewater Analysis Lab

CE663 0 0 2 30 70 100 2

Minor Project I CE664 0 0 2 50 00 50 1 21Hoursweek 1000 20 IIIrd E Elective V any one of the following

1 Environmental Impact Assessment and Audit

2 Remote Sensing and GIS in Environmental Engineering

CE7111 CE7112

3 0 0 50 100 150 3

Elective VI any one of the following 1 Air Quality Modeling 2 Hazardous Waste Management 3 Occupational Safety and Health

CE7121 CE7122 CE7123

3 0 0 50 100 150 3

Self Study open area seminar II CE713 0 0 2 50 00 50 1 Minor Project II CE714 0 0 4 00 200 200 4 Major Project part I CE715 0 0 2 200 00 200 4

18Hoursweek 750 15 IVth F Major Project Part II CE811 3 0 0 00 750 750 15 6Hrsw

k 750 15

Grand Total 3500 70

26

MTech(Civil) Environmental Engineering

GROUP lsquoArsquo SUBJECTS

CE-511 Advanced Mathematics and Statistics

Numerical Methods - Partial differential equations Newton-Raphson method Finite difference finite element method of characteristics different methods Successive over relaxation methods Optimization ndash classification and importance in Environmental Studies Single and multivariable optimization without and with constraints Linear Programming ndash different methods linear approximation of non-linear optimization Statistics - Significance Tests Frequency Distribution Characteristics of Distributions Method of Least Squares and Regression Multiple Regression Probability ndash Concepts Methods Binomial Poisson and Normal distribution Risk and uncertainty analysis

CE-512 Environmental Chemistry and Microbiology

Aquatic Chemistry Hydrological cycle structure of water molecule water as solvent principles of equilibrium chemistry pH oxidation-reduction and the application of principles of chemistry for solving Environmental Engg problems

Chemistry of pollution due to detergents pesticides polymers trace organics metals mining petroleum and radioactive compounds

Chemistry of the atmosphere Global environmental problems- chemistry of CFC ozone depletion green house effect etc

Environmental Microbiology basic principles of microbial transformation of organic matter Microbial biochemistry biodegradation acclimatization of wastes and microbial inhibition mechanisms

Structure and function of cell constituents pure and mixed cultures aerobic and anaerobic metabolism microbial growth and dynamics microbial taxonomy classification amp morphological aspects of protozoa bacteria fungi algae and other higher aquatic life forms

Bioassay tests for toxicity evaluation pathogens and indicator organisms

Environmental Biotechnology Role of microbes in water and wastewater Engg Microbiology applied to bio scrubbers and bio filters bioremediation

CE-513 Water Pollution

Water quality Detection and measurement of Water Pollution Stream surveillance Standards Criteria Objective and goal of water quality for different uses Water quality management

Modeling approaches to water quality - classification ndash Mathematical Models for water quality

DO Models for Streams Models for microorganisms decay Eutrophication models - simplified nutrient loading models for rivers and lakes Management of Water Pollution Disposal of wastewater

CE-514 Microbiology Lab

27

Microscopic Examination of Microorganisms Preparation of bacterial smear - staining - Hanging drop technique - plate count test MPN tests and MFT Tests

GROUP lsquoBrsquo SUBJECTS

CE-562 Water Engineering Design

Introduction ndash Sources of water necessity of treatment Critical Water quality parameters water quality guidelines and standards for various water uses

Unit operations ndash principles and design of aeration systems ndash two film theory water in air system air in water system Intake structures ndash Different types design criteria

Principles of sedimentation ndash types of settling and settling equations design criteria and design of settling tanks Principle of Coagulation and Flocculation ndash types of coagulants coagulant aids coagulation theory optimum dose of coagulant design criteria and numerical examples

Filtration - theory of granular media filtration Classification of filters dual and multimedia filtration Adsorption Process Disinfection Water Softening Fluoridation and defluoridation ndash Principles and design Ion Exchange-processes Application Membrane Processes Reverse osmosis Ultrafiltration Electrodyalisis corrosion and corrosion control distribution design of various components of the distribution system

Design of the units of Water Treatment Plant

CE-561 Air Pollution and Control

Definition air pollutants air pollution measurement ambient and at source Effects of air pollution Standards Meteorology Dispersion of air pollutants Air pollution control equipmentsmdashsettling chambers Inertial devices electrostatic precipitator scrubbers fitters adsorption devices combustion devices condensation devices

CE-563 Water Engineering Laboratory

Physical and chemical characteristics of water pH EC Turbidity alkalinity acidity hardness sulphates fluorides nitrates Total solids volatile solids fixed solids Residual chlorine analysis optimum coagulant dose BOD COD Determination of heavy metals in water Total organic carbon CHNS analysis

CE-564 Self Study Open Area Seminar- I

Self Study

GROUP lsquoCrsquo SUBJECTS

CE-611 Wastewater Treatment Design

Treatment objectives Methods and design fundamentals of process analysis Physical unit operations screening flow equalization mixing Physico-chemical Treatment Systems flocculation sedimentation floatation filtration chemical unit processes Biological unit processes Bio kinetics treatment and disposal of sludge Emerging technologies for wastewater treatment and their design

CE-6121 Groundwater and Seepage

28

Darcyrsquos law General hydro-dynamic equations flow nets in isotropic and anisotropic medium

Steady and unsteady flow through confined and non-confined aquifers Schwartz Christoffel transformation and its application for ground water and seepage problems

Multiple well system partially penetrating wells image wells mutual interference of wells

Storage and exploration of ground water design construction and maintenance of wells Ground water recharge and run off Water quality budgeting simulation of ground water basin Application of remote sensing for ground water

CE-6121 Instrumentation

Types of application of measurement instrumentation Generalized configuration and functional description of measu4ring instruments Motion measurement Pressure measurement Flow measurement Environmental Engg Instrumentation

CE-6131 Design of Hydraulic Structures

Project planning site investigations choice of type of dams Cost benefit studies

Non-overflow dams Gravity Arch and buttress type Rock fill and earthen dams their design stress analysis stress concentration around openings

Different types of spillways and energy dissipaters their design Preparation and protection of foundation for dams Model analysis of Hydraulic structures Instrumentation in dams Temperature control in concrete dams

CE-6132 Industrial Waste Water Treatment

Theories of waste water treatments combined treatment of raw industrial waste with domestic sewage Discharge of completely treated waste to Municipal Sewer discharge of raw waste to stream characteristics and treatment of wastes from the apparel industry Food processing industries Material industries Chemical industries Energy industries

CE-614 Air Pollution Laboratory

Experiments using High volume sampler personnel sampler RSPM sampler stack monitoring kit

GROUP lsquoDrsquo SUBJECTS

CE-6611 Global Warming and Climate Change

Energy Issues and Climate Change Alternate Energy Sources Green-House Effect as a Natural Phenomenon Green House Gases GHGs) and their Emission Sources

Quantification of CO2 Emission Global Warming Potential (GWP) of GHGs Modeling Climate change Ozone layer depletion and its control Impacts of climate change ndash Global and India Temperature Rise Sea Level rise Coastal Erosion and landslides Coastal Flooding Wetlands and Estuaries loss

Kyoto Protocol ndash Importance Significance and its role in Climate Change Carbon Trading - Mechanisms

Various Models (European Indian) Global and Indian Scenario Cleaner Development Mechanisms ndash Various Projects related to CO2 Emission Reduction Alternatives of Carbon Sequestration ndash Conventional and non-conventional techniques

29

Role of Countries and Citizens in Containing Global Warming

References

1 Packe and Smith Climate Change

2 Gilbest

CE-6611 Planning and Design of Environmental Services

Planning factors Ventilation and Air conditioning Plumbing Design of Public Bathing Places Lighting Housing with Environmental Perspective

CE-6621 Environmental Planning and Management

Environment and Sustainable Development - carrying capacity relationship with quality of life carrying capacity and resource utilization Engineering Methodology in Planning and its Limitations ndash carrying capacity based short and long term regional planning Environmental Protection - Economic development and social welfare consideration in socio economic developmental policies and planning Total cost of development and environmental protection cost Case studies on Regional carrying capacity Engineering Economics ndash Value Engineering Time Value of Money Cash Flows Budgeting and Accounting Environmental Economics Introduction economic tools for evaluation Green GDP Cleaner development mechanisms and their applications Environmental Audit ndash methods procedure reporting and case studies Total Quality Management in environmental management and protection ndash ISO 9000 14000 and 18000 series of standards

CE-6622 Solid Waste Management

Sources of solid waste types of solid waste methods of disposal of solid waste recycle and reuse problems in the management under Indian conditions

Mechanical Transformation of solid wastes screening size reduction various devices for size reduction objectives

Thermal Transformation of solid wastes pyrolysis incineration gasification

Ultimate disposal of solid wastes Landfills problems location of landfills leachate composition management of leachate landfill liners landfill covers Bio gas from landfills computations of gas quantity and its management

CE-663 Solid Waste and Industrial Wastewater Analysis Lab

Determination of calorific value of different types of wastes Determination of molecular formula using CHNS analyzer Determination of total organic carbon of wastes Determination of moisture content density of wastes

Physical and chemical analysis of wastewater from different industries

CE-664 Minor Project - I

GROUP lsquoErsquo SUBJECTS

CE-7111 Environmental Impact Assessment and Audit

Environmental Impact Assessment ndash Definition Objectives Types ndash Rapid and Comprehensive EIA EIS FONSI Step-by-step procedure for conducting EIA and Limitations of EIA Prevention of Significant Deterioration (PSD) Programme Frame work of Impact assessment scope and contents of EIA methodologies and techniques of EIA

30

Attributes Standards and Value functions Public participation in EIA Environmental Management Plan (EMP) and Disaster Management Plan (DMP) EIA Case Studies ndashThermal Power Plant Mining Fertilizer Construction Projects Air port Water and Wastewater Treatment Plants

CE-7112 Remote Sensing and GIS in Environmental Engineering

Remote Sensing Definition ndash Ideal Remote Sensing System ndash Sensors and Types ndash Remote Sensing Satellite ndash IRS and INSAT specifications ndash Applications of remote sensing ndash DIP Techniques GIS Definition ndash Data and Types ndash Sources of data - Global Positioning System (GPS) ndash Data Structure ndash Types of Analysis ndash Errors ndash Applications of GIS Optimal Routing of Solid wastes using GIS ndash Case Study Environmental Siting of Industries and Zoning Atlas Development Re-modeling of Water Distribution System using GIS ndash Case Study Sustainable Urban Development Planning using GIS Environmental Degradation Assessment using RS and GIS Ground water vulnerability modeling using GIS

CE-7121 Air Quality Modeling

Introduction to air pollution modeling Approaches to model formulation Model Classification Criteria for model selection Air pollution meteorology ndash meteorological parameters stability classification plume rise plume behavior dispersion parameters Basic diffusion equation deterministic numerical and statistical modeling approach Introduction to boundary layer turbulence Physical modeling approach stochastic modeling approach to air pollution dispersion Theory of Gaussian plume model and its application Introduction to indoor air quality models ISCST3 CALINE4 ROADAIR Case studies

CE-7122 Hazardous Waste Management

Introduction Sources Classification Regulations for Hazardous Waste Management Hazardous Waste Characterization Designated Hazardous Wastes Waste Minimization and Resource Recovery ndash Approaches Development of a Waste Tracking System Selection of waste Minimization Process Case Studies Transportation of Hazardous Waste ndash requirements regulations containers bulk and non-bulk transport Emergency Response Physico-chemical Chemical and Biological Treatment of hazardous waste Thermal treatment - Incineration and pyrolysis Sanitary landfill ndash design approach leachate and gaseous collection system Facility Siting and Process Selection for treatment storage disposal facility (TSDF) Soil contamination and site remediation ndash bioremediation processes monitoring of disposal sites

CE-7123 Occupational safety and Health

Introduction Occupational Safety and Health Act Occupational Safety and Health Administration Right to know Laws Indian Acts ndash Labour Act Factories Act OSHA Accident ndash Causation investigation methods and different models Ergonomics ndash need Task Analysis Preventing Ergonomic Hazards Ergonomics Programme Occupational Hazard and Control - Hazard Analysis Human Error and Fault Tree Analysis Emergency Response Hazards and their control in different manufacturing and processing industries Fire Prevention and Protection - types of Fire Fire Development and its Severity Effect Extinguishing Fire Electrical Safety Product Safety Occupational Health - Health and Safety Considerations Personal Protective Equipment Health problems in different types of industries ndash construction textile steel and food processing pharmaceutical occupational Health and Safety considerations in Wastewater Treatment Plants

CE-713 Self study Open Area Seminar II

CE-714 Minor Project II

CE-715 Major Project Part-I

GROUP lsquoFrsquo SUBJECTS

CE-811 Major Project Part II

Syllabus for M Tech (Hydraulics and Water Resources Engineering)

Scheme for MTech ( Hydraulics and Water Resources Engineering)

Sem

Gro

up

Course details Course

Code

L T P Internal

Marks

External

Marks

Total

Marks

Credit

s

A Advanced Mathematics CE 531 3 0 0 50 100 150 3

I Advanced Hydrology CE 532 3 0 0 50 100 150 3

Advanced Open Channel Hydraulics CE 533 3 0 0 50 100 150 3

Hydraulic Engg Lab-1 CE 534 0 0 2 30 70 100 2

B Advanced Fluid Mechanics CE 581 3 0 0 50 100 150 3

Water Power Engineering CE 582 3 0 0 50 100 150 3

Hydraulics Engg Laboratory-II CE 583 0 0 2 30 70 100 2

Self study open area seminar-I CE 584 0 0 2 50 0 50 1

21Hoursweek 1000 20

II

C Planning amp management of Water Resources CE 631 3 0 0 50 100 150 3

Elective ndashI any one of the following

Ground water Hydrology

Coastal Engg

Hydrometeorology

CE 6321

CE6322

CE 6323

3 0 0

50 100 150 3

Elective ndash II any one of the following

Design of Hydraulic structures

Advanced irrigation and drainage Engg

Water pollution control and stream pollution

CE 6331

CE 6332

CE 6333

3 0 0

50 100 150 3

Hydraulics Engg Laboratory-III CE 634 0 0 2 30 70 100 2

D Elective ndash III any one of the following

Application of Geotech Engg And GIS in water

resources

River mechanics and sediment transport

Urban storm water drainage

CE 6811

CE 6812

CE 6813

3 0 0

50 100 150 3

Elective ndash IV any one of the following

Design of flood control and river training works

Water Resources Economics

Hydrodynamics stability

CE 6821

CE 6822

CE 6823

3 0 0

50 100 150 3

Hydraulic Engg Lab- IV CE 683 0 0 2 30 70 100 2

Minor project -I CE 684 0 0 2 50 00 50 1

21Hoursweek 1000 20

III E Elective ndash V any one of the following

Environmental Impact Assessment

Subsurface investigations

Water and soil conservation Engg

CE 7311

CE 7312

CE 7313

3 0 0

50 100 150 3

Elective ndash VI any one of the following

System Techniques in Water Resources Engineering

Computational Hydraulics

Hydro Informatics and Simulations

CE 7321

CE 7322

CE 7323

3 0 0

50 100 150 3

Self Study open area Seminar CE733 0 0 2 100 00 100 2

Minor Project ndash II CE 734 0 0 4 0 300 300 6

Major Project ndash I CE 735 0 0 6 200 00 300 6

18 HrsWeek 1000 20

IV F Major Project ndash II CE 831 0 0 6 00 1000 1000 15

6 Hrswk 1000 15

Grand Total 3500 70

ADVANCED MATHEMATICS

Paper Code L T P Cr

CE 531 3 0 0 3

Numerical method Finite Differences Numerical integration and differentiation Numerical solution of ordinary

differential equations and their application to engineering structures Poissonrsquos Laplacersquos and bi-harmonic

equations Relaxation methods and their application to Civil Engineering problems Complex variables Conformal

mapping and Swartz-Christoffel transformation applied to flow problems

Statistics and Probabilities Statistical parameters Discrete and continuous distributions frequency analysis

confidence limits Regression and correlation Stochastic modelling and Time series analysis Chi-square test of

goodness of fit Sensitivity analysis and decision making

Advanced Computer programming techniques and their applications to Engineering problems

Optimization techniques using Linear Non-linear and dynamic programming

ADVANCED HYDROLOGY

Paper Code L T P Cr

CE 532 3 0 0 3

Review of basic principles of hydrology Concepts of linear and non-linear modelling in rainfall-Runoff models

Probability and statistical analysis in hydrology correlation and regression analysis Lumped and distributed flood

routing methods Flood estimation methods

Time Series Analysis

Synthetic data generation Simple and multiple linear regression

At site frequency analysis

Analysis of low flows

Stream flow forecasting

Introduction to stochastic modelling and time series analysis

ADVANCED OPEN CHANNEL HYDRAULICS

Paper Code L T P Cr

CE 533 3 0 0 3

Energy and momentum equation Effect of Non-uniform velocity distribution

metering of flow Hydraulic Jump Formations of jump in expanding and contracting channel jump type jump

control jump on sloping floors Gradually varied steady flow and rapidly varied steady flow in open channels

surface profiles in GVF-analysis different method of computations Chowrsquo-s methods standard step method finite

difference method Unsteady Flow Waves celerity of wave boundary conditions standing and progressive wave

positive and negative surges Dam break problem deep water group velocity solitary wave Introduction to Fluvial

hydraulics sediment transport

HYDRAULIC ENGINEERING LAB I

Paper Code L T P Cr

CE 534 0 0 2 2

I) Computation of energy momentum correction factors by use of current meter and pitot tube

II) Calibration of weir and venturi-flumes determination of modular limit

III) Normal critical and brink depth-their experimental Verification and determination of Manningrsquos n

IV) Backwater profiles

V) Hydraulic jump characteristics

VI) Bed formations Threshold condition in sediment transport

ADVANCED FLUID MECHANICS

Paper Code L T P Cr

CE 581 3 0 0 3

Review of basic laws of fluid flow in integral and differential form kinematics Ideal fluid flow Newtonian fluid

flow and applications Creeping flow Two dimensional Flow Patterns Sink and Source Laplace equation solution

by Graphical method Theoretical concepts of boundary layer Boundary layer theory Turbulent boundary layer

Boundary Layer Separation and its Stability Transition turbulence analysis and Measurement Correlation and

Statistical Theories Fundamentals of compressible flows Modelling and dimensional analysis

WATER POWER ENGINEERING

Paper Code L T P Cr

CE 582 3 0 0 3

Comparative study of Hydro-Thermal and Nuclear Projects Investigations of Hydro-electric projects-types of

development nature of demand and supply interconnection pondage and storage

Design of intakes gates air inlet valves penstocks and anchor blocks Power canals Forebay

Type of turbines their selection Design of turbine components like scroll casing runner draft tube governing of

turbine

Characteristics and model studies of turbines

Water hammer phenomenon physical interpretation water hammer studies by different methods for sudden and

gradual closure of valve

Surge tanks governing equation for analysis stability calculation of surge by different methods surge in power

canals surge control Design principles of Power House

HYDRAULIC ENGINEERING LABORATORY II

Paper Code L T P Cr

CE 583 0 0 2 2

Flow visualisation studies Boundary layer drag and lift on immersed bodies Measurement of turbulent

quantities) some experiments on wind tunnel

PLANNING AND MANAGEMENT OF WATER RESOURCES

Paper Code L T P Cr

CE 631 3 0 0 3

Principles of engineering economics discounting techniques un-certainity planning horizon Selection of optimal

alternatives Application of linear non linear and dynamic programings in water resources Optimal sequencing and

scheduling of resources Planning of water resources projects cost ndashbenefit analysis for irrigation water power and

floods control projects

Principles and practice of water resources planning and management Purposes water resources developments

Engineering economy in water resources planning

Reservoir planning river basin development Factors affecting irrigation and power development examples of

multipurpose project in India

Storage and related problems optimum storage Rule curve minimum storage and its effect on the cost of power

Computer applications in the designs of water resources systems Water shed management Management of reservoir

operations

GROUND WATER HYDROLOGY

Paper Code L T P Cr

CE 6321 3 0 0 3

Introduction Steady and unsteady flow through confined and unconfined aquifers Schwartz-Christoffel

transformation and its application for ground water flow and seepage problems Numerical Techniques for solution

of ground water flow

Ground water movement Darcyrsquos law permeability hydraulic conductivity ground water in perforated regions

Isotropic and anisotropic aquifers and general flow equations Multiple well system partially penetrating wells

image wells mutual interference of wells

Ground water modeling techniques Porous media models analog models and digital computer models

Investigations of ground water Surface and subsurface investigation of ground water Water level measurement

fluid conductivity Storage and exploration of ground water Design Construction and Maintainence of wells

simulation of ground water basin Application of remote sensing for ground water

Artificial recharge of ground water Concept of artificial recharge re-charge methods recharge on water

spreading recharge mound and induced recharge General hydro-dynamic equations flow nets in isotropic and

anisotropic medium Water harvesting and legislation

COASTAL ENGINEERING

Paper Code L T P Cr

CE 6322 3 0 0 3

Definition-wave classification-linear theory of waves-assumptions and derivations of relationship of wave

characteristics-pressure within a progressive wave wave energy energy flux-wave decay-Transformation of waves-

Fundamental aspects of stokes theory

Reflection Refraction Diffraction of wave-Breaking of waves-types criterion and importance of breaking- wave

force on structure-vertical sloping curved and stepped barrier-force due to non-breaking breaking and broken

waves-Force on piles

Need for forecasting- SMB and PNJ methods of wave forecasting

Origin and classification of tides Karwinrsquos equilibrium theory of tides-effects on structure-seiches and tsunamis

Types of sediment and movement-types of beaches and beach profile Long Shore drift and its engineering

significance Causes of coastal erosion and methods of protection Introduction to outfall design necessity and few

design examples

HYDROMETEOROLOGY

Paper Code L T P Cr

CE 6323 3 0 0 3

Atmosphere General Circulation Composition and Structure of Atmosphere Role of

Meteorology in Hydrology

Precipitation Process ndash Adiabatic Process Stability and Instability of Atmosphere

Atmosphere Thermodynamics

Clouds ndash Classification Formation and Characteristics

Climate Preparation of Climatological norms and Climate Classification

Weather Charts Preparation Analysis and Interpretation Weather Forecast

Monsoon ndash Monsoon Circulation Monsoon Troughs Monsoon Depression and Tropical

Cyclones

Hydro-meteorological Instrumentation and Observations

Use of Radar and Satellites in Hydrology

Storm Analysis Storm Selection Storm Maximization Probable Maximum Precipitation

Meteorological Homogeneity Storm Transposition

Computer applications in the design of hydraulic structures

DESIGN OF HYDRAULIC STRUCTURES

Paper Code L T P Cr

CE 6331 3 0 0 3

Design of spillways energy dissipation below spillways and their construction management

Non-overflow dams Gravity Arch and buttress dams rock fill and earthen dams their design and management at

the site Stress analysis stress concentration around openings Model analysis of hydraulic structures

Design of weirs on permeable foundation silt excluders and different types of silt ejectors and construction

management of diversion head works Case studies of large dams

Foundations design well foundation coffer dams drilled shafts and piled foundations Stability analysis

construction maintenance and testing of foundations Codal provisions for foundation design of these structures

ADVANCED IRRIGATION AND DRAINAGE ENGINEERING

Paper Code L T P Cr

CE 6332 3 0 0 3

Basic Irrigation Development Problems Types of development water rights and disputes Land classification and

development Investigation for irrigation planning water resources conjunctive use of surface and ground water

reclamation of sewage and drainage flow Recharging of groundwater by flood flows

Water requirement of crops Consumptive use depth and frequency of irrigation cropping pattern

Modern methods of irrigation their economics and design irrigation network and irrigation structures Management

of irrigation analysis of existing irrigation projects irrigation losses and wastes irrigation efficiency control and

maintenance of irrigation works

Problems of water logging-salinity and alkalinity land drainage problems- design of surface and sub-surface

drainage system reclamation

Systems approach in planning of irrigation and drainage projects

WATER POLLUTION CONTROL AND STREAM SANITATION

Paper Code L T P Cr

CE 6333 3 0 0 3

Water quality and stream quality standards

Organic self purification-quantitative definition-re-oxygenation-oxygen balance and stream

dissolved oxygen profile-oxygen sag curve-Streeter Phelprsquos equation-Critical deficit problems

Microbial self purification-pathogenic microorganisms of sewage origin-indices of

contamination-enumeration-per-capita contribution-seasonal variations-death rate survival in

the stream environment

Classification of streams-natural self purification process-disposal of wastewater Rational

stream sanitation practices-dual objectives of stream sanitation practices-the science

and art of applied stream sanitation-stream survey-types of stream survey-execution of stream

surveys

Purification in estuaries-evaluation of self purification in estuaries-tides and currents distribution

of waste loads by tidal translation-sea water intrusion-waste assimilation capacity

of estuaries-bacterial contamination-stable wastes

Case studiessimulation studies water quality modelling using qual2E WASP

HYDRAULICS ENGG LABORATORY-III

Paper Code

L T P Cr

CE 634 0 0 2 2

Experiments based on models studies in irrigation engineering river mechanics river flow dynamics and sediment

transport Experiments on instrumentation techniques

APPLICATION OF GEOTECH ENGG AND GIS IN WATER RESOURCES

Paper Code

L T P Cr

CE 6811 3 0 0 3

Introduction sources of energy electromagnetic spectrum electromagnetic radiation reflection transmission and

absorption Interaction of EMR with atmosphere scattering refraction absorption transmission atmospheric

windows Brief review of thermal and microwave remote sensing their utility merit and demerits Introduction

geographical concepts and terminology difference between image processing system and GIS utility of GIS

Various GIS packages and their salient features essentials components of GIS data acquisition through scanners

and digitizers Raster and vector data introduction descriptions raster and vector data raster versus vector raster

to vector conversion remote sensing data in GIS

Introduction importance of water resources and hydrology components of water resources hydrological cycle role

of remote sensing Geo-morphological analysis of watershed determination of various geo-morphometric

parameters using conventional and remote sensing data digital elevation model data input interpolation

techniques surface generation assessment of accuracy extraction of various watershed parameters Irrigation water

management and scheduling performance evaluation of irrigation command areas performance indicators mapping

of irrigation command areas using temporal remote sensing data Flood plain identification and management use of

remote sensing data products digital based extraction of flood plain parameters and indices drought identification

and management conventional approach data requirements and methods drought Indices and its assessment using

remote sensing data

RIVER MECHANICS AND SEDIMENT TRANSPORT

Paper Code L T P Cr

CE 6812 3 0 0 3

River morphology river systems hydraulics regime and dynamics Theory of meandering Inter relationship

between river dimensions sediment load and water flow River response to river training works Local scour around

hydraulic structures Density currents and sedimentation of reservoirs

Introduction sediment properties threshold conditions for uniform sediments exposure and sheltering effects in

non-uniform sediments critical-tri-active stress of non-uniform cohesion-less sediments and cohesive soil regimes

of flow analysis of ripples dunes and anti-dunes resistance to flow and velocity distribution in alluvial streams

Bed load suspended load and wash load computation of bed load for uniform and non uniform sediments

Mechanism of suspension distribution of suspended load computation of suspended load and total load

URBAN STORM WATER DRAINAGE

Paper Code L T P Cr

CE 6813 3 0 0 3

Hydraulics of closed and open drains under different flow conditions unsteady steady and spatially varied flows

Design criteria of drains based on hydraulic considerations

Hydrologic design scale selection of design level Risk analysis of safety margins and safety factors

Design storms precipitation depth intensity duration frequency relationships Design hyetographs from storm

events

Design flows storm sewer design Codal requirements for storm water drainage

DESIGN OF FLOOD CONTROL AND RIVER TRAINING WORKS

Paper Code L T P Cr

CE 6821 3 0 0 3

Basic causes of flood Flood prone areas in India and their problems case history of some important river basins of

India Engineering and administrative methods of flood plane regulation Economic aspects of flood control

schemes cost benefit analysis Flood forecasting flood warning and flood fighting

Morphological study of river behaviour Theories of river meandering and river regimes Necessity principles and

methods of river training Case history of river training works in India and abroad Design of Levees Groynes Cut-

offs and Guide bunds etc River training works for different hydraulic structures

WATER RESOURCE ECONOMICS

Paper Code L T P Cr

CE 6822 3 0 0 3

Principles of engineering economics discounting techniques un-certainity planning horizon Selection of optimal

alternatives Application of liner non-linear and dynamic programmings in water resources Optimal sequencing

and scheduling of resources Planning of water resources projects cost- benefit analysis for irrigation water power

and flood control projects

HYDRO DYNAMIC STABILITY

Paper Code L T P Cr

CE 6823 3 0 0 3

Control volumes and system approach- Stokersquos Gauss and Greenrsquos theorem and applications

Conservation of mass momentum moment of momentum and energy equations

Potential flows Basic flow patterns combination of flow patterns application to civil engineering problems

Conformal transformation Viscous flow Navier-Stokersquos equations Exact and approximate solutions

Boundary layer theory Boundary layer equations and its solution boundary layer separations and its control theory

of stability drag on immersed bodies

Formulation of hydrodynamic stability problems in various situations of flows and particularly for parallel flows

Waves and allied experimental studies Study of laminar to turbulent transition

CE 683 HYDRAULIC ENGINEERING LAB ndashIV

Paper Code L T P Cr

CE 683 0 0 2 2

Application of CAD in hydraulic Engineering Two and three dimensional analysis of gravity dams Seepage and

stability analysis of embankment Design of weirs on permeable foundations Design of canals and transitions

Design of gates and valves Design of pipe networks

ENVIRONMENTAL IMPACT ANALYSIS FOR WATER RESOURCE PROJECTS

Paper Code L T P Cr

CE 7311 3 0 0 3

Objectives of environmental impact assessment methodology for EIA Baseline study scooping checklist scaled

and weighted matrices networks overlays index methods Prediction and Assessment of impacts on air water land

demography and Biological Environment Impact analysis of Hydro power different case studies environmental

Impact Analysis-Laws and Status in India Rehabilitation and resettlement

Identification of process operation imbalances resulting in resources loss and their impact on environment

SUBSURFACE INVESTIGATIONS

Paper Code L T P Cr

CE 7312 3 0 0 3

Introduction amp broad classification of subsurface methods

Direct Methods

Excavation amp Pitting

Well Drilling Techniques

Drill Stem Testing

Geological Well Logs

Indirect Methods

Geophysical Well Logging Electrical Well logging methods Normal amp Lateral Resistivity

Logs Self Potential Logs Induction amp Micro focused logs electrical logging practices

evaluation of aquifer parameters

Radiation logging (Natural gamma neutron amp gamma gamma logging) - Acoustic logs

Caliper logs amp Dip-meter surveys amp their applications in groundwater

prospecting

WATER AND SOIL CONSERVATION ENGINEERING

Paper Code L T P Cr

CE 7313 3 0 0 3

Water conservation Rain water harvesting techniques water shed development ground water recharging check

dams reservoirs and aquifers control of infiltration seepage and evaporation control of effluent and waste water

disposal control of agricultural run off and siltation Plan utilisation of water resources flood planes zone

management reuse and recycling of treated waste water effluent irrigation

Soil Conservation Introduction to soil erosion mechanisms and its causes and control sheet erosion rill erosion

gully erosion control of erosion by bunding terracing contour trenching gully stabilizing check dams drop

spillways chute spillways grass land management and forest management reclamation of saline and usher soils

remediation of contaminated soils Case studies on soil and water conservation practices

SYSTEM TECHNIQUES IN WATER RESOURCES ENGINEERING

Paper Code L T P Cr

CE 7321 3 0 0 3

System Concepts

System concepts definitions needs for system approach different types of

system parameters and variables

Linear Programming

Revision Big M Method duality sensitivity analysis Application of Linear

Programming for Hydraulics amp Water Resource

Non Linear Programming

Unconstrained one Dimensional search methods Dichotomous search method

Fibonacci Golden section multivariable unconstrained gradient techniques

steepest ascent and descent methods Newtonrsquos methods Application of

Dichotomous search method Fibonacci amp Golden section to the various sectors of

Water Resource Engineering FP methods constrained Lagrangian multiplier

techniques Kuhn Tuckerrsquos conditions penalty function methods

Dynamic Programming

Principle of optimality recursive equations Application of Dynamic

programming to Water Resource Engineering

Stochastic Methods

Queuing theory simulation technique sequencing model Morkovrsquos process

Capitalisation

Annuity benefit-cost analysis Benefit Cost Analysis for multi purpose water

resource projects

Geometric Programming

Polynomial unconstrained minimization problem arithmatics geometric

unequality solution of unconstrained geometric programming constraints

minimization geometric programming with mixed inequality constrained

Games Theory

COMPUTATIONAL HYDRAULICS

Paper Code L T P Cr

CE 7322 3 0 0 3

Introduction to finite element and finite volume techniques in computational fluid dynamics

Numerical solution of Navier-Stokersquos equation and boundary layer equation Reynoldrsquos equation-turbulence

modelling

Separated flows transient flow through pipes surge tanks steady uniform and non-uniform flow through open

channels

Spatially varied flow Numerical solutions unsteady flow through open channels

Application of finite element method in other areas of water resources eg Multiphase flow estuarine and lakes

oceans waves tidal flow etc Specification related to storm water drainage

HYDROINFORMATICS AND SIMULATIONS

Paper Code L T P Cr

CE 7323 3 0 0 3

Introduction

Concept of hydro-informatics scope of internet and web based modelling in water

resources engineering

Introduction to multi criterion decision support system ndash Components for

modelling software

Introduction to Simulation

Different simulation techniques ndash Applications of simulation techniques in

hydraulics

Introduction to Artificial Neural Networks

Networks and its training-Back propagation algorithm Conjugate gradient

algorithm Cascade correlation algorithm Applications of ANN in WRE Genetic Algorithm (GA)

Concept Basic principle of GA Working principle of GA Coding Fitness

function GA Operations Reproduction Cross over Mutation Applications of

GA in Water Resources Engineering

DELHI TECHNOLOGICAL UNIVERSITY

SCHEME OF EXAMINATION

AND

COURSE OF READING

FOR

MTech (Software Engineering)

Syllabus applicable to the students seeking admission to

MTech (Software Engineering) Course

SCHEME

Paper

No

Subject Code

No

Title of the Course Internal

Marks

External

Marks

Total

Marks

Credits Semester

Total

1

2

3

4

GROUP A CO 511

CO 512

CO 513

CO 514

Software Engineering Methodologies

Data Warehousing amp Data Mining

Advances in Internet amp Web

Technologies

Software Engineering Lab

50

50

50

30

100

100

100

70

150

150

150

100

3

3

3

2

1000

(20

credits)

5

6

7

8

GROUP B

CO 561

CO 562

CO 563

CO 564

Software Project Management Artificial Intelligence and Expert Systems

Artificial Intelligence Lab

Self-study Open Area Seminar-I

50

50

30

50

100

100

70

-

150

150

100

50

3

3

2

1

9

10

11

12

GROUP C CO 611

CO 612

CO 613

CO 614

Software Validation Verification amp

Testing

Elective-I

Elective-II

Software Testing Laboratory

50

30

50

50

100

70

100

100

150

100

150

150

3

2

3

3

1000

(20

credits)

12

13

14

15

GROUP D

CO 661

CO 662

CO 663

CO 664

Elective-III

Elective-IV

Lab based on Electives

Minor Project-I

30

50

50

50

70

100

100

-

100

150

150

50

2

3

3

1

16

17

18

19

20

GROUP E

CO 711

CO 712

CO 713

CO 714

CO 715

Elective-V

Elective-VI

Self-study Seminar ndashII

Minor Project-II

Major Project-I

50

50

100

-

-

100

100

-

300

300

150

150

100

300

300

3

3

1

4

4

1000

(15

credits)

21 GROUP F CO 811

Major Project-II

-

1000

1000

15

1000

(15

credits)

List of Electives

Electives I (Group C) Any one subject can be chosen from the following

Software Requirements Engineering

Software Quality amp Metrics

Bio-Informatics

Advances in Information Systems

Modeling and Simulation

Electives II (Group C) Any one subject can be chosen from the following

Real-Time Systems

Quantum Computing

Recent Trends in Distributed Systems

Cluster amp Grid Computing

Pervasive Computing

Electives III (Group D) Any one subject can be chosen from the following

Virtual Reality

Advances in Multimedia Systems

Wireless amp Mobile Communication

Data Security and Cryptography

Fault Tolerant System Design

Electives IV (Group D) Any one subject can be chosen from the following

Digital Image Processing

Neural Networks amp Fuzzy Logic

Biometrics

Robotics Engineering

Pattern Recognition

Electives V (Group E) Any one subject can be chosen from the following

Advances in Software Engineering

Software Architecture amp Design Patterns

Component Based Technology

Intellectual Property Rights

Human Computer Interface

Electives VI (Group E) Any one subject can be chosen from the following

Natural Language Processing

Computer Vision

Machine Learning

Semantic Web

Information Retrieval

First Year MTech (SE) I Semester

CO 511 Software Engineering Methodologies

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Review of Software Engineering Principles amp Techniques Discussion on System

Development amp Methodologies Object-Oriented System Development

Unit 2 Software Engineering Processes Introduction to Object Oriented Paradigm Object-

Oriented Process Models Rational Unified Process (RUP)

Unit 3 Methodologies Yourdon method for software design Modified Yourdon Method

Object Modeling Technique (OMT) of Rumbaugh

Unit 4 Unified Modeling Language (UML) UML diagrams such as use case diagrams class

diagram sequence diagrams state transition diagrams etc

Unit 5 Agile development methodologies

Unit 6 Applications A complete case study of Software development using above

Methodologies Concepts of Computer-Aided Software Engineering

Tools Knowledge about current CASE tools used in the industry

Suggested Readings-

Text Books

1 Ian Sommerville ldquoSoftware Engineeringrdquo 7th Edition Addison-Wesley 2004ISBN 81-

7758-530-4

2 Roger S Pressman ldquoSoftware Engineering ndash A Practitionerrsquos Approachrdquo - 4th edition

McGraw Hill Publications

3 Grady Booch James Rambaugh Ivar Jacobson ldquoUnified Modeling Language Users

Guiderdquo 2nd Edition Addison- Wesley ISBN ndash 0321267974

Reference Books

1 Ivar Jacobson Grady Booch James Rumbaugh ldquoThe Unified Software Development

Processrdquo Pearson Education

2 Yourdon ldquoModern Structured Analysisrdquo PHI

3 KK Aggarwal and Yogesh Singh ldquoSoftware Engineeringrdquo New Age Publications 2009

CO 512 Data Warehousing amp Data Mining

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Data Warehousing - Basic concepts in data warehousing Collecting the requirements

of data warehouse Data Warehouse Architecture Design Implementationamp Maintenance

OLAP in data warehouse Data warehousing and the web Further Development of Data Cube

Technology From Data Warehousing to Data Mining

Unit 2 Data Mining Concepts Data mining primitives Basics of data mining Query language

Designing GUI based on a data mining query language Architectures of data mining systems

Unit 3 Mining Association Rules in Large Databases Association Rule Mining Mining

Single Dimensional Boolean Association Rules from Transactional Databases Mining

Multilevel Association Rules from Transaction Databases Mining Multidimensional Association

Rules from Relational Databases and Data Warehouses From Association Mining to Correlation

Analysis Constraint Based Association Mining

Unit 4 Classification and Prediction Issues Regarding Classification and Prediction

Classification by Decision Tree Induction Bayesian Classification Classification by

Backpropagation Classification Based on Concepts from Association Rule Mining Other

Classification Methods Prediction Classifier Accuracy

Unit 5 Cluster Analysis in Data Mining Types of Data in Cluster Analysis A Categorization

of Major Clustering Methods Partitioning Methods Density Based Methods Grid Based

Methods Model Based Clustering Methods Outlier Analysis

Unit 6 Mining Complex Types of Data Multidimensional Analysis and Descriptive Mining of

Complex Data Objects Mining Spatial Databases Mining Multimedia Databases Mining Time

Series and Sequence Data Mining Text Databases Applications Systems products and research

prototypes Additional themes in data mining Trends in Data mining spatial mining and Web

Mining Web concept mining Web structure mining Web Usage mining

Suggested Readings-

Text Books

1 PPonnian ldquoData Warehousing Fundamentalsrdquo John Wiley

2 MHDunham ldquoData Mining Introductory amp Advanced Topicsrdquo Pearson Education

3 HanKamber MKaufman ldquoData Mining Concepts amp Techniquesrdquo

Reference Books

1 Ralph Kimball ldquoThe Data Warehouse Lifecycle Tool Kitrdquo John Wiley

2 MBerry GLinoff ldquoMaster in Data Miningrdquo John Wiley

3 WHInmon ldquoBuilding the Data Ware housesrdquo Wiley Dreamtech

CO 513 Advances in Internet amp Web Technologies

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Emergence of the Internet Basics notions amp working parts of the Internet E-Mail file

transfer telnet Usenet gopher wais Archie and veronica Internet chat

Unit 2 Web Development Developing Web using HTML XML ASP Concepts of Web

Programming using Scripting Languages such as JavaScript CGI PHP etc Database

Connectivity with MySQL and JDBC

Unit 3 Web Research amp Practices The World Wide Web Impact Opportunities and

Challenges Evolution of Search Engines

Unit 4 Web Search amp Mining Framework Supporting Technologies concepts applications

types amp tools Quantifying the Web

Unit 5 Crawling Techniques The task of a web crawler Crawler algorithms Indexing

techniques Ranking in Web

Unit 6 Advanced Research Topics Duplicate Detection Contextual Search etc

Suggested Readings-

Text Books

1 Raj Kamal ldquoInternet and Web Technologiesrdquo Tata McGraw Hill edition

2 Mark Levene ldquoAn Introduction to Search Engines and Web Navigationrdquo Pearson

Education ISBN 0321306775

3 Soumen Chakrabarti ldquoMining the Web Discovering Knowledge from Hypertext

Datardquo Morgan-Kaufmann Publishers ISBN 1-55860-754-4

Reference Books

1 Wendy Willard ldquoHTML A Beginnerrsquos Guiderdquo Tata McGraw-Hill

2 Chris Bates ldquoWeb Programming building internet applicationsrdquo 2nd edition Wiley

Dreamtech

3 Sebesta ldquoProgramming World Wide Webrdquo Pearson

4 Ullman Larry ldquoPHP and MySQL for Dynamic Web Sitesrdquo Peachpit Press

5 Pierre Baldi Paolo Frasconi Padhraic Smyth ldquoModeling the Internet and the Webrdquo John

Wiley and Sons Ltd ISBN 0470849061

CO 514 Software Lab

Practical - 2 Hrs per week Practical - 100 Marks

Software Lab based on using latest CASE Tools At least one Minor Project to be developed for

an application based on methodologies covered in the course

CO 561 Software Project Management

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introduction Project Management concepts Process Framework Project Planning

Software Life Cycle Models Artifacts of the Project Management Process

Unit 2 Cost and Scheduling Estimation Models Various Levels of COCOMO for Cost

Effort Schedule and Productivity Estimation Approaches to Effort Cost Estimation and

Schedule Estimation factors through COCOMO II Putnam Estimation Model Algorithmic

models

Unit 3 Project Management Techniques Project Organizations and Responsibilities

Establishing Project Environment Risk Management Process Project Tracking and Control

Defect Tracking Concepts such as Process monitoring and audit Reviews Inspections and

Walkthroughs

Unit 5 Risk Estimation What is Risk Framework for Managing Risks Risk Identification

Risk Analysis and Prioritization Risk Avoidance and Mitigation Strategies Risk Monitoring

Estimating

Unit 4 Activity Planning including CPM and PERT Network planning model Activity-on-

arrow network Precedence network Forward pass Backward pass Critical path Slack and

float

Unit 6 Advance Topics in Software Project Management Discussion on future Software

Project Management Practices amp Modern Project Profiles Next Generation Software Economics

Modern Process Transitions

Suggested Readings-

Text Books

1 Watts S Humphrey ldquoManaging the Software Processrdquo Pearson Education

2 Walker Royce ldquoSoftware Project Managementrdquo Pearson Education

3 Pankaj Jalote ldquoSoftware Project Management in Practicerdquo Pearson Education

Reference Books

1 Bob Hughes ldquoSoftware Project Managementrdquo TMH

2 Chris Kemerer ldquoSoftware Project Management Readings and Casesrdquo

CO 562 Artificial Intelligence amp Expert Systems

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introduction The AI Problems AI Techniques Basic Problem solving methods state

space search problem characteristics Production systems characteristics issues in design of

Intelligent search algorithm

Unit 2 Heuristic search Techniques Hill climbing techniques Best First search Problem

Reduction Constraint Satisfaction Means-End Analysis

Unit 3 Knowledge Representation Knowledge Representation issues Knowledge

Representation using Predicate logic Semantic Nets Semantic Frames Conceptual Dependency

scripts Knowledge representation with uncertainty

Unit 4 Programming Languages Fundamental and concepts of Programming languages like

Prolog or Lisp Relationship of languages with Knowledge representation and inferences

Unit 5 Expert Systems What and Why of expert systems Structure of an Expert system

interaction with an expert system Design of an Expert system implementing expert system shell

Expert System Development techniques amp tools with Case Study Construction of Programs

using different data structure

Unit 6 Advanced topics Applications of AI in Game Playing amp Natural Language Processing

Concepts of Fuzzy Logic Introduction to Intelligent Agents

Suggested Readings-

Text Books

1 Artificial Intelligence E Rich and K Knight TMH 2nd ed 1992

2 Introduction to Expert Systems Peter Jackson AWP MA 199

3 Introduction to AI and Expert Systems DW Patterson PHI 1992

Reference Books

1 Artificial Intelligence - an Engineering Approach RJ Schalkoff McGraw Hill Int

Ed Singapore 1992

2 Principles of AI NJ Nilsson Narosa Publ House 1990

3 Artificial Intelligence Structures and Strategies for Complex Problem Solving (5th

Edition) George F Luger 2005 Addison-Wesley ISBN-10 0321263189

4 Artificial Intelligence A Guide to Intelligent Systems (2nd Edition)Michael

Negnevitsky 2005 Addison-Wesley ISBN-10 0321204662

CO 563 Artificial Intelligence Lab

Practical - 2 Hrs per week Practical - 100 Marks

Objective of the course - To develop intelligent systems in different engineering domains like

Games Theorem Proving Natural Language Processing etc

CO 564 Self-study Open Area Seminar-I

Practical - 2 Hrs per week Sessional - 50 Marks

Objective of the course - Students should explore the research areas amp industry practices in the

field of Software Engineering Artificial Intelligenceamp other applied areas The students will

submit a symposium on the topics selected

First Year MTech (SE) II Semester

CO 611 Software Validation Verification amp Testing

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introductory concepts Verification ampValidation Terminologies like Goals Role

Objectives Limitations Approaches amp Applicability

Unit 2 Software Testing Testing Process Limitations of Testing Testing activities

Unit 3 Levels of Testing Unit Testing Integration Testing System Testing

Debugging Domain Testing Regression Testing Slice based testing

Unit 4 Software Testing Techniques Detail study of Functional Testing Structural Testing

Object Oriented Testing

Unit 5 Software Testing Tools Taxonomy Methodology to evaluate automated testing Using

tools Load Runner Win runner and Rational Testing Tools Java Testing Tools JMetra JUNIT

Cactus and other recent tools

Unit 6 Advanced Topics on Testing Prioritizing the Test-cases Web Applications Testing

Off-the-shelf component testing security testing Data-warehouse Automated test data

generation

Suggested Readings

Text Books

1 Paul C Jorgenson Software Testing A Craftsmanrsquos approach CRC Press 1997

2 Desikan Ramesh Software Testing principles and Practices Pearson Education

Reference Books

1 William E PerryEffective Methods for Software Testing John Wiley

2 Steven R Rakitin Software Verification and Validation for Practitioners and Managers

2nd edition Artech House

3 Boris Beizer ldquoSoftware Testing Techniquesrdquo Second Volume Second Edition Van

Nostrand Reinhold New York 1990

4 Louise Tamres ldquoSoftware Testingrdquo Pearson Education Asia 2002

5 Boris Beizer ldquoSoftware System Testing and Quality Assurancerdquo Van Nostrand einhold

New York 1984

6 Glenford Myers ldquoThe Art of Software Testingrdquo John Wiley amp Sons Inc New York

1979

CO 612 Software Testing Lab

Practical - 2 Hrs per week Practical - 100 Marks

Objectives of the course -Software Testing Lab where hands-on experience on various Testing

Tools A project development for an application using these tools

Elective I Group C

Lectures - 3 Hrs per week Theory - 150 Marks

CO 613

Elective II Group C

Lectures - 3 Hrs per week Theory - 150 Marks

CO 614

Elective III Group D

Lectures - 3 Hrs per week Theory - 150 Marks

CO 662

Elective IV Group D

Lectures - 3 Hrs per week Theory - 150 Marks

CO 663

CO 664 Minor Project I

Practical - 2 Hrs per week Sessional - 50 Marks

The objective of this course is to develop complete Software Application- CASE Tool based on

the subjects studied during the Course

Second Year MTech (SE) III Semester

Elective V Group E

Lectures - 3 Hrs per week Theory - 150 Marks

CO 711

Elective VI Group E

Lectures - 3 Hrs per week Theory - 150 Marks

CO 712

CO 713 Self-Study Open Area Seminar -II

Practical - 2 Hrs per week Practical - 100 Marks

Objective of this course - This study should be in continuation with earlier study taken during

the Self-Study Open Area Seminar I and students must present some state-of-art innovative

techniques in the area of interest which can serve as the base-work for a workshopConference

Paper

CO 714 Minor Project -II

Practical - 4 Hrs per week Practical - 300 Marks

Objective of this course - Innovative Development of complete Software Application or a

CASE Tool based on the subjects studied amp area of interest

CO 715 Major Project Part-I

Practical - 3 Hrs per week Practical - 300 Marks

Second Year MTech (SE) IV Semester

CO 811 Major Project Part ndashII

Practical - 6Hrs per week Practical - 500 Marks

Elective I (Group C) CO 613

Software Requirements Engineering

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Software Requirements Essential of Software requirements Different Dimensions of

Software Requirements Good practices for requirements engineering improving requirements

processes and risk management

Unit 2 Software Requirements Engineering Review of various activities of Requirements

Engineering like requirements elicitation requirements analysis documentation amp review

Discussion on current trends in requirements elicitation requirements analysis models and

verifying requirements requirements specification amp requirements prioritization

Unit 3 Software Requirements Management (RM) Principles and practices of RM

Requirements attributes Change Management Process Requirements Traceability Matrix Links

in requirements chain

Unit 4 RM Tools Rational Requisite pro Caliber RM benefits of using a RM tool

Unit 5 Advances in Requirement Engineering Commercial requirements management

techniques amp tools implementing requirements management automation

Unit 6 Latest trends in requirements engineering such as aspect-oriented requirement

engineering agent-based requirement engineering

Suggested Readings

Text Book

1 Rajesh Naik and Swapna Kishore ldquoSoftware Requirements and Estimationrdquo Tata

McGraw Hill

2 Karl E Weigers ldquoSoftware Requirementsrdquo Microsoft Press 1999

3 Ellen Gottesdiener Requirements by Collaboration Workshops for Defining Needs

Addison Wesley 2002

Reference Books

1 Ian Graham Requirements Engineering and Rapid Development Addison Wesley 1998

2 Ivy Hooks and Kristin Farry Customer-Centered Products Creating successful products

through smart Requirements Management Amacom 2001

3 Dean Leffingwell and Don Widrig Managing Software Requirements A Unified

Approach Addison Wesley 1999

Software Quality amp Metrics

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Software Quality Assurance Framework What is Quality Software Quality

Assurance Components of Software Quality Assurance Software Quality Assurance Plan Steps

to develop and implement a Software Quality Assurance Plan

Unit 2 Quality Standards ISO 9000 and Comparison ISO Standards CMM CMMI PCMM 3

Sigma 6 Sigma Software Quality Models

Unit 3 Measurement basics What is Software Metrics Application Areas of Metrics

Categories of Metrics Measurement Scale Axiomatic Evaluation of Metrics on Weyukerrsquos

Properties Analyzing the Metric Data Summary statistics for preexamining data Metric Data

Distribution Outlier Analysis Correlation Analysis Exploring Analysis

Unit 4 Measuring Structure and Size Size Estimation Halstead Software Science Metrics

Information flow Metrics Measuring Quality Software Quality metrics based on Defects

Usability Metrics Testing Metrics Reliability Models

Unit 5 Object Oriented Metrics Coupling Metrics Cohesion Metrics Inheritance Metrics

Size Metrics Reuse Metrics

Unit 6 Advanced topics in software quality Empirical software engineering research in

software quality

Suggested Readings-

Text Books

1 Mordechai Ben MenachemGarry S Marliss ldquoSoftware Qualityrdquo Thomson Learning

2 Stephen H Kan ldquoMetrics and Models in Software Quality Engineeringrdquo Pearson

Education (Singapore) Pvt Ltd 2002

3 Norman E Fenton and Shari Lawrence ldquoSoftware Metricsrdquo PfleegerThomson 2003

Reference Books

1 D Galin ldquoSoftware Quality Assurance From Theory to Implementationrdquo Addison

Wesley

2 Allan C Gillies ldquoSoftware Quality Theory and Managementrdquo Thomson Learning

2003

3 Mike Konrad and Sandy Shrum CMMI Mary Beth Chrissis Pearson Education

(Singapore) Pvt Ltd 2003

Bio-Informatics

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introduction biology physics Biological hierarchy Information stages Physical

processes Information understanding

Unit 2 Methods of gene sequencing Detailed discussion on Sequences searching methods

Unit 3 Gene expression Current and prospective methods of gene profiling Data acquisition

Data standardization Linear approximations of data DNA chips Protein targeting Data

normalization Linear view

Unit 4 Statistics approaches Probabilistic notions Multivariate issues Clustering Information

handling Experimental and computational methods of structure determination for proteins and

nucleic acids

Unit 5 Ontology Annotation of genes their products and functions System biology evolution

hierarchy Medical informatics Software support Software availability Software targets Text

parsing BioPerl Statistics R-system

Unit 6 Recent Advances amp Applications of Bio-Informatics Recent trends in Computing

with bio-systems

Suggested Readings

Text Books

1 David W Mount ldquoBioinformatics Sequence and Genome Analysisrdquo Cold Spring

Harbor Laboratory Press

2 Andreas D Baxevanis ldquoBioinformatics A Practical Guide to the Analysis of Genes and

Proteinsrdquo Second Edition

3 Richard Durbin Sean R Eddy Anders Krogh Graeme Mitchison ldquoBiological Sequence

Analysis Probabilistic Models of Proteins and Nucleic Acidsrdquo Cambridge University

Press

Reference Books

1 DE Krane and ML Raymer ldquoFundamental Concepts of Bioinformaticsrdquo Pearson

Education 2003

2 B Bergeron ldquoBioinformatics Computingrdquo Prentice ndashHall 2003

Advances in Information Systems

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 E-Commerce Models Applications Creation of E-Commerce Sites Introduction to

ERP Packages

Unit 2 CRM sales Marketing amp Service Management BPOBCP Guidelines Merits-

Demerits Call Centre Brief perspective on technological concepts case studies

Unit 3 E-banking Inter-Banking Intra- Banking Transactions E-Payments Techniques for

incorporating Securities in E-banking Services

Unit 4 E-Learning Models Virtual Campus Video Conferencing Building Online

Community

Unit 5 E-Logistics Logistics amp Supplier Chain Management Warehousing Management

Transportation Distribution Management E-Governance Models Challenges Strategies amp

Tactics E-agriculture Type of Agriculture Information amp Technique dissemination Future

Trade Marketing Query Redressing Systems Information Kiosk IVR Case Study

Unit 6 Knowledge Management (KM) Components amp Type of knowledge Knowledge

building Models KM architecture KM Tools Approaches Approaches to GISGPS Nature of

Geographic Data Getting Map on Computers Standards Design Implementation amp

Deployment phases

Suggested Readings

Text Books

1 M Papazoglou and PMA Ribbers E-Business Organizational and Technical Foundations John Wiley and Sons

2 Daryl Morey Mark Maybury and Bhavani Thuraisingham Knowledge Management Classic and Contemporary Works

3 Basics of Ecommerce NIIT PHI

Reference Books

1 Erfan Turban et al Electronic CommercendashA Managerial Perspective Pearson Education

2 Andrew V Winston Electronic Commerce ndash a Mangerrsquos guideR Kalokota Pearson

Education

Modeling amp Simulation

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Basic Simulation Modeling The Nature of Simulation Systems Models and Types of

Simulation Advantages Disadvantages and Pitfalls of Simulation

Unit 2 Modeling Complex Systems Introduction List Processing in Simulation Approaches to

Storing Lists in a Computer

Unit 3 Simulation Software Comparison of Simulation Packages with Programming

Languages

Unit 4 Classification of Simulation Software General-Purpose Simulation Packages

Object-Oriented Simulation

Unit 5 Building Valid Credible and Appropriately Detailed Simulation Models

Experimental Design Sensitivity Analysis

Unit 6 Optimization Simulation of Manufacturing Systems

Suggested Readings-

Text Books

1 Frank L Severance System Modeling and Simulation - an Introduction John Wiley

2 Simulation Modeling and Analysis Third Edition Law Kelton (Mc-Graw Hill)

Elective II (Group C) CO 614

Real-Time Systems

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Real-time systems Real-time systems models Types of real-time systems Internal

structure of real-time systems Performance measures Examples of real-time systems and real-

world applications Modeling amp Designing real-time systems

Unit 2 Real-Time Process Management Task scheduling for Uniprocessor systems handling

priorities with critical section interrupts task allocation amp scheduling for multiprocessor

systems adaptive scheduling

Unit 3 Programming Environment In depth Knowledge of RTOS programming languages

tools amp techniques

Unit 4 Real-Time System Design Design techniques for Reliability Fault Tolerance amp other

application specific quality considerations

Unit 5 Trends in Real-Time System Design amp Development in fields such as Robotics

Unit 6 Introduction to research topics

Suggested Readings-

Text Books

1 AC Shaw Real-Time Systems and Software Wiley

2 JE Cooling Real-Time Software Systems International Thompson Computer Press

3 WA Halang and KM Sacha Real-Time Systems World Scientific

Reference Books

1 Real-Time Systems Design and Analysis PH Laplante IEEE Press

2 Real-Time Systems J Liu Prentice-Hall 2000

3 Real-Time Computer Control R Bennett Prentice-Hall

4 Real-Time Systems CM Krishna and KG Shin McGraw-Hill

Quantum Computing

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introduction to Quantum Computers Qubits amp their representation

Unit 2 Quantum Elements Logic Gates Circuits Architectures Algorithms

Unit 3 Quantum Information Quantum Key Distribution teleportation Single photons EPR

pairs

Unit 4 Grid Computing Data and Computational Grids Grid Architectures and its relations to

various distributed technologies Autonomic computing Cluster Setup amp its advantages

Unit 5 Performance models amp simulations Networking protocols amp IO Messaging Systems

Examples

Unit 6 Process Scheduling Load Sharing amp Balancing Distributed Shared memory parallel

IO Pervasive Computing concepts amp scenarios Hardware amp software Device Connectivity

Suggested Readings-

Text Books

1 Introduction to Quantum Computing Philip Kaye etal Oxford University Press

2 Introduction to Quantum Computers Gennady Berman World Scientific

3 Quantum Computation and Quantum Information M Nielsen and I Chuang

Cambridge University Press Cambridge 2000

Reference Books

1 Classical and Quantum ComputationA Yu Kitaev AH Shen and MN Vyalyi

American Mathematical Society Providence 2002

2 Problems amp Solutions in Quantum Computing amp Information WH Steeb and Y

HardyWorld Scientific River Edge NJ 2004

Recent Trends in Distributed Systems

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Introduction Distributed System Models Inter-process Communication issues in

design of Distributed systems current amp future

Unit 2 Communications Layered Protocol Distributed Objects amp Remote Invocation Remote

Procedure Call

Unit 3 Time Logical clocks vector clocks direct dependency clocks matrix clocks

Unit 4 Resource Allocation Distributed Shared Memory Process Scheduling Load Balancing

amp Load Sharing Mutual Exclusion Election algorithms

Unit 5 Distributed File Systems Coordination amp Agreement Distributed Transaction

Consistency amp Replication Consistency Models Distribution amp Consistency Protocols

Unit 6 Advanced Topics in Distributed Systems Parallel Processing Parallel amp Distributed

Programming Case Studies in detail amp research directions

Suggested Readings-

Text Books

1 Distributed Operating Systems Concepts and Design PKSihna PHI 2007

2 Distributed Systems Principles and Paradigms 2nd Ed Andrew S Tanenbaum and

Maarten Van Steen Prentice Hall 2007 3 Distributed Operating Systems and Algorithms R Chow T Johnson Addison-

Wesley Publishing Company 1997 ISBN 0-201-49838-3

Reference Books

1 Distributed Systems Concepts and Design 4th Ed by Coulouris G Dollimore J

and Kindberg T Addison-Wesley 2006

Cluster amp Grid Computing

Lectures - 3 Hrs per week Theory - 150 Marks

Unit 1 Cluster Computing Introduction to concepts in Cluster based distributed computing

Hardware technologies for cluster computing and software for cluster computing and different

Software Architecture for Cluster Computing

Unit 2 Programming Programming Models and Paradigms features and performance of

standard MPI variants Derived data types communicators

Unit 3 Resource management and scheduling Managing cluster resources single system

images system level middleware distributed task scheduling monitoring and administering

system resources Parallel IO and Parallel Virtual File System Scheduling Condor Maui

Scheduler Portable Batch System (PBS)

Unit 4 Grid Computing Grids and Grid Technologies Programming models and

Parallelization Techniques Grid Security Infrastructure Setting up Grid deployment of Grid

software and tools and application execution

Unit 5 Standard application development tools and paradigms Performance evaluation

tools HINT netperf netpipe ttcp Iperfmessage

Unit 6 Data Management Application Case Study Molecular Modeling for Drug Design and

Brain Activity Analysis Resource management and scheduling

Suggested Readings-

Text Books

1 William Gropp Ewing Lusk Thomas Sterling Beowulf Cluster Computing with

Linux 2nd edition MIT Press

2 Bart Jacob Michael Brown Introduction to grid computing

3 Gregory F Pfister In Search of Clusters The ongoing battle in lowly parallel

computing Second Edition Prentice Hall Publishing Company 1998