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London, 5 July 2007

Doc. Ref: EMEA/249428/2007

COMMITTEE ON HERBAL MEDICINAL PRODUCTS (HMPC)

DRAFT

LIST OF REFERENCES FOR ASSESSMENT OF:

Eleutherococci radix Eleutherococcus senticosus (Rupr. et Maxim.) Maxim.

(eleutherococcus root)

The EMEA acknowledges that copies of the underlying works used to produce this monograph were provided for research only with exclusion of any commercial purpose.

1. Abascal K, Yarnel E, 2003. Increasing vitality with adaptogens. Multifaceted herbs for treating physical and mental stress. Altern Complement Therapies, 9, 2:54-60.

2. Abramova JI, Chorny ZH, NatalenkoVP et al, 1972a. Pharmacological analysis for the adaptogenic action mechanism of Eleutherococcus and dibazole. Medicines of the Soviet Far East. Vladivostok. 11:102-5. [Article in Russian]

3. Abramova JI, Chorny ZH, NatalenkoVP et al, 1972b. Stimulation of catecholamine and serotine circulation caused by Eleutherococcus and dibazole. Medicines of the Soviet Far East. Vladivostok. 11:106-8. [Article in Russian]

4. Afanasiev BG, Zhestovsky VA, Mazurov KV et al, 1973. Comparative assessment of the effect produced by Eleutherococcus and the acid-saline beverage on the development of adaptation to intermittent exposure to heat. Vopr Pitan, 32, 1:3-9. [Article in Russian]

5. Afanasyeva TN, 1981. Effect of Eleutherococcus on dynamics of electrocardiographs disturbances at experimental myocardial infarction. In: New Data on Eleutherococcus and other adaptogens. Vladivostok. 34-8. [Article in Russian]

6. Afanasyeva TN, Krivchik AA, Kurtasova TP, 1986. Some mechanisms of positive effect of Eleutherococcus upon the course and outcome of experimental myocardial infarction. In: New Data on Eleutherococcus: Proceedings of the II International Symposium on Eleutherococcus (Moscow 1984). Vladivostok. 81-9. [Article in Russian]

7. Afanasyeva TN, Lebkova NP, 1987. The effect of Eleutherococcus on subcellular heart structures in experimental myocardial infarct. Biull Eksp Biol Med, 103, 2:212-5. [Article in Russian]

8. Aicher B, Wozniewski T, 1998. Eleutherococcus. In: Blaschek W, Hansel R, Keller K et al, eds. Hagers Handbuch der Pharmazeutischen Praxis, 5th ed. Folgeband 2. Berlin-Heidelberg-New York: Springer. 556-97. [Article in German]

9. Akimov AA, 1966. Influence of Eleuterococcus on the therapeutic action of cortisone in rats with the interwoven lymphosarcoma. In: Brekhman II, ed. Eleutherococcus and other adaptogens among the Far Eastern plants. Vladivostok. 7:117-20. [Article in Russian]

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10. Alekseeva LV, Bykhovtseva TL, Bezlepkin VG et al, 1975. Influence of liquid extracts of Ginseng and Eleutherococcus roots on some systems of the metabolism. Proceedings USSR Akad Sciences, Biological series, 4:609-12. [Article in Russian]

11. Amaryan G, Astvatsatryan V, Gabrielyan E et al, 2003. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever. Phytomedicine, May, 10 (4):271-85.

12. Andreev IF, 1976. Effect of Eleutherococcus extract on some functions of the digestive organs. Vrach Delo, (8):40-1. [Article in Russian]

13. Anetai M, Jamagishi T, Kaneshima H, 1987. Quantitative determination of pharmacologically active constituents in the stems of Acanthopanax senticosus collected in Hokkaido. Hokkaidoritsu Eisei Kenkyushoho 37:85-7.

14. Anisimov MM, Suprunov NI, Prokofeva NG, 1972. Effect of compounds isolated from Araliaceae family plants on the biosynthesis of protein in vitro. Rast Resur, 8:378-80. [Article in Russian]

15. Anisimov MM, Fronert EB, Frolova GM et al, 1973. Influence of Eleutherococcus senticosus glycosides on early embryogenesis in the sea urchin. Proceedings USSR Akad Sciences, Biological series, 4:590-3. [Article in Russian]

16. Anton R, 1987. Reflexions sur quelques nouvelles acquisitions en phytotherapie. J Pharm Belg, 42:138-51. [Article in French]

17. Antonova AI, 1979. Extract of Eleuterococcus in the treatment of the atrophies of optical nerve. Oftalmolog J, 34, 3(227):183-4. [Article in Russian]

18. Arushanyan EB, Baida OA, Mastyagin SS et al, 2003. The effect of Eleutherococcus on short-term memory and visual perception in healthy humans. Eksper Clin Pharmacol, 66, 5:10-3. [Article in Russian]

19. Asano K, Takakhashi T, Kugo Kh et al, 1986a. Effects of Eleutherococcus senticosus on physical performance and resources in maximal and submaximal work. In: New Data on Eleutherococcus: Proceedings of the II International Symposium on Eleutherococcus (Moscow 1984). Vladivostok. 166-70. [Article in Russian]

20. Asano K, Takakhashi T, Miyashita M et al, 1986b. Effect of Eleutherococcus senticosus extract on human physical working capacity. Planta Med, Jun, (3):175-7.

21. Asanova NA, Teslov SV, Burnasheva LA et al, 1977. On the possibility of the complex use of rhizomes and roots of Eleuterococcus in medicine and the cosmetic. In: Search of pharmacological and chemotheraputic means from the products of synthesis and natural substances. (Transactions of scientific papers). Perm. 58-61. [Article in Russian]

22. Awang DVC, 1991a. Maternal use of Ginseng and neonatal androgenization. JAMA, April 10, 264-5, (14):1828.

23. Awang DVC, 1991b. Maternal use of Ginseng and neonatal androgenization. JAMA, July 17, 266, 3:363.

24. Awang DVC, 1996a. Eleuthero. Canad Pharm J, 129:52-4.

25. Awang DVC, 1996b. Siberian ginseng toxicity may be a case of mistaken identity. CMAJ, Nov 1, 155(9):1237.

26. Awang DVC, 2003. What in the name of Panax are those other "Ginsengs"? HerbalGram, 57:35-40.

27. Azizov AP, 1997. The effect of Eleutherococcus, elton, Leuzea, and levton on the blood coagulation system in physical exertion of athletes. Eksp Klin Farmakol, 60, 5:58-60. [Article in Russian]

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28. Azizov AP, Seifulla RD, 1998. The effect of elton, leveton, phytoton and adapton on the work capacity of experimental animals. Eksp Klin Farmakol, 61, 3:61-3. [Article in Russian]

29. Baburin EF, 1966a. The influence of Eleutherococcus on work results and hearing sensitivity in radio telegraphers. In: Brekhman, II ed. Eleutherococcus and other adaptogens among the Far Eastern Plants. Vladivostok. 7:179-84. [Article in Russian]

30. Baburin EF, 1966b. The influence of Eleutherococcus on the Hearing organ. In: Brekhman II, ed. Eleutherococcus and other adaptogens among the Far Eastern plants.Vladivostok. 7:173-8. [Article in Russian]

31. Baburin EF, Porkalov PV, Polonsky VV, 1970a. Influence of Eleutherococcus on some parameters of functional condition in organism of divers at chamber tests. Medicines of the Soviet Far East. Khabarovsk.10: 67-71. [Article in Russian]

32. Baburin EF, Polonsky VV, 1970b. The first results of the use of Eleutherococcus for preservation of working capacity in divers on actual diving. Medicines of the Soviet Far East. Khabarovsk. 10:72-3. [Article in Russian]

33. Baburin EF, Tarasov IK, Alexejev VN, 1972. On the prophylaxis of motion sickness. Medicines of the Soviet Far East. Vladivostok. 11:120-5. [Article in Russian]

34. Baburin EF, 1976. In: Brekhman II, ed. Adaptation processes and biologically active substances. Vladivostok. 91. [Article in Russian]

35. Badalyan M, Panosyan V, Gabrielyan E, 2005. Randomized trial of a fixed combination (KanJang) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections. 12(8): 539-47.

36. Baldwin CA, Anderson LA, Phillipson JD, 1986. What pharmacists should know about Ginseng. Pharm J, 583-6.

37. Baranov AI, 1979. On a Technical English Name for Eleutherococcus. Taxon, 28(5/6):586-7.

38. Baranov AI, 1982. Medicinal uses of Ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. J Ethnopharmacol Nov, 6(3):339-53.

39. Baranov AI, 1986. On the problem of the Russian technical name for Eleutherococcus. In: New Data on Eleutherococcus: Proceedings of the II International Symposium on Eleutherococcus (Moscow 1984). Vladivostok. 221-2. [Article in Russian]

40. Barchas JD, Mefford IN, Roth K et al, 1981. Neuroregulators and stress. Naval Res Rev, 23(4):2-12.

41. Barenboim GM, Sterlina AG, Fisenko AP et al, 1984. Studies of Natural Killers Activators with Eleutherococcus extract. In: 2nd International Symposium on Eleutherococcus. All-Union Cancer research center. Moskow. [Article in Russian]

42. Barenboim GM, Sterlina AG, Bebyakova NV et al, 1986. Investigation of the pharmacokinetics and mechanism of action of Eleutherococcus glycosides. VIII. Investigation of natural killer activation by the Eleutherococcus extract. Khim Farm Zh, 20, 7:914-7. [Article in Russian]

43. Barenboim GM, 2005. Eleutherococcus: Application and the mechanism of action. http://www.oxyfreshww.com/nutrition/articles/part5.asp

44. Barkan AI, Gaiduchenya LI, Makarenko IA, 1980. Effect of Eleutherococcus on respiratory viral infectious morbidity in children in organized collectives. Pediatriya, 4:65-6. [Article in Russian]

45. Barna P, 1985. The case of Ginseng. Lancet, Sept, 7, 2(8454):548.

46. Batin VV, Popov YuB, Lifar VK, 1981. Experience in using sugar and an Eleutherococcus extract with the workers of the hot shops and the night shifts of the Raichikhinsk Glass Plant. Hyg Tr Prof Zabol, 5:36-8. [Article in Russian]

47. Bazaz'ian GG, Liapina LA, Pastorova VE et al, 1987. Influence of the adaptogen Eleutherococcus on the function of the anticoagulation system in older animals. Fiziol Zh USSR Im IM Sechenova, Oct, 73(10):1390-5. [Article in Russian]

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48. Belay VE et al, 1966. Pharmacology in space medicine. XVII International Astronautical Congress, Madrid, 9-15 Oct.

49. Belonosov IS, Krasilnikova AP, Postupajev VV et al, 1966. First results of the use of Eleutherococcus on some aspects of metabolism. In: Brekhman II, ed. The final results of Eleuterococcus studies in the USSR. 53-5. [Article in Russian]

50. Ben-Hur E, Fulder S, 1981. Effect of Panax ginseng saponins and Eleutherococcus senticosus on survival of cultured mammalian cells after ionizing radiation. Am J Chin Med, Spring, 9(1): 48-56.

51. Berdyshev VV, 1970. Effect of Eleutherococcus and physical training on an organism`s state in sailors in the tropics I-II. Medicines of the Soviet Far East. Khabarovsk. 10:60-6. [Article in Russian]

52. Berdyshev VV, 1977. The use of Eleutherococcus for normalization of the organism`s state in sailors in the tropics. In: Adaptation and Adaptogens. Proceedings of the 2nd Symposium (May,1975). 119-25. [Article in Russian]

53. Berdyshev VV, 1981a. Effect of Eleutherococcus on body functions and the work capacity of sailors on a cruise. Voen Med Zh, 2:48-51. [Article in Russian]

54. Berdyshev VV, 1981b. Effect of the long-term intake of Eleutherococcus on the adaptation of sailors in the tropics. Voen Med Zh, May, (5):57-8. [Article in Russian]

55. Berdyshev VV, Strelchuk SI, 1986. Comparative studies of the geroprotective effect of Eleutherococcus, Ginseng and Eglantine extracts on Drosophila melanogaster. In: New Data on Eleutherococcus: Proceedings of the II International Symposium on Eleutherococcus (Moscow 1984). Vladivostok. 145-8. [Article in Russian]

56. Berdyshev VV, 1995. Some specific effects of single doses of adaptogens. In Valeology; Diagnosis, Means and Practice in Health Care, Brekhman II (ed.). Int. Collection of scientific papers, issue 2, Vladivostok, Dalnauka, 105-117. [Article in Russian]

57. Berzins VK, Blumberg MYa, Zvirgzda AYu, 1965. Effect of zymozan on complement properdin levels in rabbits. In: Biochemical Factors and Body Reactivity. Riga: Zinatne Publishers. 63-73. [Article in Russian]

58. Besdetko GN, 1966a. Experimental research of a fluid extract of Eleutherococcus as antidiabetic. In: Brekhman II, ed. The final results of Eleuterococcus studies in the USSR. 46. [Article in Russian]

59. Besdetko GN, 1966b. The prophylactic and curative effects of Eleutherococcus on the course of alloxan-induced diabetes. In: Brekhman II, ed. Eleutherococcus and other adaptogens among the Far Eastern plants. Vladivostok. 7:81-4. [Article in Russian]

60. Besdetko GN, Brekhman II, Dardymov IV et al, 1973. Effect of Eleutherococcus glycosides on RNA-polymerase activity in nuclei from skeletal muscles and liver after physical strain. Vopr Med Khim, 19, 3:245-8. [Article in Russian]

61. Besdetko GN, 1977. Pharmacological regulation of biosynthesis of nucleinic acids at stress. In: Adaptation and Adaptogens. Proceedings of the 2nd Symposium (May,1975). 112-5. [Article in Russian]

62. Besdetko GN, Dardymov IV, Speranskaya NV, 1980. Influence of Ginseng and Eleutherococcus on content of cyclic nucleotides in some organs of rats. Pharmacol Toxicol, 43, 4:448. [Article in Russian]

63. Besdetko GN, German AV, Shevchenko VP et al, 1981. Study of the pharmacokinetics and mechanism of action of Eleutherococcus glycosides. I. Incorporation of tritium to eleutheroside B, the kinetics of its accumulation and elimination from the animal body. Khim Farm Zh, 15, 1:28-33. [Article in Russian]

64. Besdetko GN, German AV, Khasina EI et al, 1982. Study of the pharmacokinetics and mechanism of action of Eleutherococcus glycosides. V. Metabolism and kinetics of binding with blood serum components. Khim Farm Zh, 16, 5:16-9. [Article in Russian]

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65. Besdetko GN, 1986. The role of cyclic nucleotides in adaptogenous effect of Eleutherococcus. In: New Data on Eleutherococcus: Proceedings of the II International Symposium on Eleutherococcus (Moscow 1984). Vladivostok. 31-4. [Article in Russian]

66. Bespalov VG, Alexandrov VA, Yaremenko KV et al, 1992. The inhibitory effect of phytoadaptogenic drugs bioginseng, Eeleutherococcus senticosus and Rhaponticum carthamoides on development of N-nitrosoethylurea-induced tumors of the nervous system in rats. Vopr Oncol, 38(9):1073-80. [Article in Russian]

67. Bhargava KP, Singh N.1986. Comparative evaluation of anti-stress activity of Eleutherococcus senticosus, Panax ginseng and Ocimum sanctum. In: New Data on Eleutherococcus: Proceedings of the II International Symposium on Eleutherococcus (Moscow 1984). Vladivostok. 60-5. [Article in Russian]

68. Bladt S, Wagner H, Woo WS, 1990. Taiga-Wurzel. DC- und HPLC-Analyse von Eleutherococcus- bzw. Acanthopanax-Extrakten und diese enthaltenden Phytopräparaten. Dtsch Apoth Ztg, 130/27:1499-508. [Article in German]

69. Blokhin BN, 1966a. Effect of extracts from the roots and leaves of Eleutherococcus on the working capacity of athletes. In: Materials of the 3rd Conference of the Central Research Laboratory of the Tomsk Medical Institute. Tomsk. 134-5. [Article in Russian]

70. Blokhin BN, 1966b. The Influence of Eleutherococcus Root and Leaf Extract on Human Work Capacity under Static and Dynamic Workloads. In: Brekhman II, ed. Eleutherococcus and other adaptogens among the Far Eastern plants. Vladivostok. 7:191-4. [Article in Russian]

71. Blumenthal M ed., 1998. Eleuthero root. The Complete German Commission E Monographs. Austin, TX, American Botanical Council. 684.

72. Bobkov YuG, Vinogradov VM, Katkov VF et al, 1984. Pharmacological correction of fatigue. Moskow: Medicine. 207 p. [Book in Russian]

73. Bogach VV, Timoshin SS, Kozlov VK et al, 1986. Immunomodulating action of eleutherosides at an experimental virus infection. In: New medical preparations from plants of Siberia and the Far East. Tomsk. 22-3. [Article in Russian]

74. Bohn B, Nebe CT, Birr С, 1987. Flow-cytometric studies with Eleutherococcus senticosus extract as an immunomodulatory agent. Arzneimittel-Forsch/Drug Res, 37, 2, 10:1193-6.

75. Bohn B, Nebe CT, Birr C, 1988. Immunopharmacological effects of Eleutherococcus senticosus extract as determined by quantitative flow cytometry. Int J Immunopharmacol, 10(Suppl 1):67.

76. Bolkhovitinova SS, Zvereva LA, 1981. Application of Eleutherococcus for antonatal prophylaxis of fetus hypotrophy. In: New Data on Eleutherococcus and other adaptogens. Vladivostok. 84-7. [Article in Russian]

77. Bolkhovitinova SS, 1986. Influence of Eleutherococcus on pregnancy termination for mother and fetus: an experimental clinical investigation. In: New Data on Eleutherococcus: Proceedings of the II International Symposium on Eleutherococcus (Moscow 1984). Vladivostok. 208-12. [Article in Russian]

78. Bol'shakova IV, Lozovskaia EL, Sapezhinskii II, 1997. Photosensitizing and photoprotective properties of extracts from groups of medicinal plants. Biofizika. Jul-Aug, 42(4):926-32. [Article in Russian]

79. Boon-Niermeijer EK, van den Berg A, Wikman G et al, 2000. Phyto-adaptogens protect against environmental stress-induced death of embryos from the freshwater snail Lymnaea stagnalis. Phytomedicine, 7:389-99.

80. Borchers AT, van de Water, Kenny TP et al, 1998. Comparative effects of three species of Ginseng on human peripheral blood lymphocyte proliferative responses. Int J Immunother, 14:143-52.

81. Bradley PR, ed., 1992. Eleutherococcus. British Herbal Compendium, Vol. 1. Bournemouth:British Herbal Medicine Association.

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82. Brandis SA, 1962. On the comparative characteristic of the tonic and stimulative action of Eleutherococcus during physical work and inhalation of gas mixtures with different contents of Oxygen. In: Symposiums on Ginseng and Eleutherococcus. XX meeting on investigations of Ginseng and other medicinal plants of Far East. Vladivostok. 46-7. [Article in Russian]

83. Brandis SA, Pilovitskava VN, 1966a. On the Question of the effectiveness of using Eleutherococcus root extract for Work in a high temperature environment. In: Brekhman II, ed. Eleutherococcus and other adaptogens among the Far Eastern plants. Vladivostok. 7:155-66. [Article in Russian]

84. Brandis SA, Pilovitskava VN, 1966b. The effectiveness of using extract of Eleutherococcus roots during prolonged physical work and inhalation of gas mixtures enriched with Oxygen. In: Brekhman II, ed. Eleutherococcus and other adaptogens among the Far Eastern plants. Vladivostok. 7:141-53. [Article in Russian]

85. Brekhman II, 1957. Ginseng. Leningrad: Medicine. 182 p. [Book in Russian]

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87. Brehkman II, 1960b. Eleutherococcus. A new Stimulant and Tonic. In: The VI Lenin Military Institute of Physical Culture and Sports. Leningrad. 6-21. [Article in Russian]

88. Brehkman II, 1960c. Toxicity and general action of Eleutherococcus. In: Eleutherococcus root - new stimulating and tonic remedy. VI Lenin Military Institute of Physical Culture and Sports. Leningrad. 6-21. [Article in Russian]

89. Brekhman II, 1961. Eleutherococcus – the new medicinal herb from Araliaceae family. Komarov`s Reading АN USSR. Vladivostok. 9:3-41. [Article in Russian]

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91. Brekhman II, 1963a. Comparative data on pharmacological effect of Ginseng, Eleutherococcus, Echinopanax and Aralia roots. Materials to the studies of ginseng and other therapeutical medicines of the Far East, 5:219-27. [Article in Russian]

92. Brekhman II, Oleinikova TP, 1963b. Comparative data on the influence of Ginseng and Eleutherococcus on artificial hyperglycemia in rabbits and man. Materials to the studies of ginseng and other therapeutical medicines of the Far East, 5:249-51. [Article in Russian]

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95. Brekhman II, Kirillov OI, 1966a. The protective action of Eleutherococcus during stress. In: Brekhman II, ed. Eleutherococcus and other adaptogens among the Far Eastern plants. Vladivostok. 7:9-12. [Article in Russian]

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100. Brekhman II, Kirillov OI, 1969a. Effect of Eleutherococcus on the alarm-phase of stress. Life Sciences, part I: Physiology and Pharmacology, 8(3):113-21.

101. Brekhman II, Dardymov IV, 1969b. New substances of plant origin which increase nonspecific resistance. Ann Rev Pharmacol, 9:419-30.

102. Brekhman II, Dardymov IV, 1969c. Pharmacological investigation of glycosides from Ginseng und Eleutherococcus. Lloydia, 32:46-51.

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119. Bronnikov YuN, 1968. Indications of the immunological effectiveness of the combined use of dysentery ultraviolet vaccines and Eleutherococcus under experimental conditions. Zh Mikrobiol Epidemiol Immunobiol, Nov, 45(11):151. [Article in Russian]

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