dr. john gallacher digital health assembly 2015
TRANSCRIPT
![Page 1: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/1.jpg)
An integrated Research environment dedicated to dementia
![Page 2: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/2.jpg)
Our approach: dementia is a preventable
outcome, not a disease
Pathologies underlying dementia develop through life and represent the outcome of interactions between gene-environment-lifestyle
Jack et al: Lancet Neurology 2013
![Page 3: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/3.jpg)
Age
Preclinical
Prodromal
Dementia
60 75 90 45
Cognitive Health
The challenge
Identify early determinants
Identify early treatments to delay onset
Identify treatments To relieve symptoms and slow progression
![Page 4: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/4.jpg)
Age
Preclinical
Prodromal
Dementia
60 75 90 45
Cognitive Health
The challenge
Identify early determinants
Identify early treatments to delay onset
Identify treatments To relieve symptoms and slow progression
![Page 5: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/5.jpg)
Age
Preclinical
Prodromal
Dementia
60 75 90 45
Cognitive Health
The challenge
Identify early determinants
Identify early treatments to delay onset
Identify treatments To relieve symptoms and slow progression
![Page 6: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/6.jpg)
Science step-change
• Dementia dedicated ‘big data’ platform
• Triangulation between multiple independent datasets
• Closer synergy between scientific specialties
• Closer partnership between academics and industry
• More targeted analytic questions
• Reducing transaction costs………
![Page 7: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/7.jpg)
Methods Development
Dementia Resources
Readiness Cohort
Amyloid Cohort
Genetics Discovery
Cohort
Omics Discovery
Cohort
Biostatistics
Dementia Outcomes
Cognitive Assessment
Trials Recruitment
ELSI
Brain & iPSC Donation
Deep & Freq. Phenotyping
Experimental Medicine
Synaptic Function
Immunity
Vascular Determinants
Metabolic Determinants
Early Phase Trials
Research Networks
Imaging
Stem cell (iPSC)
Informatics
DPUK
Analytics
Portal Informatics Platform
22 Cohorts
Cohort Integration
Research-based Infrastructure
![Page 8: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/8.jpg)
The Cohorts
Mature Population Cohorts
Familial Disease Cohorts
Prodromal Population Cohorts
![Page 9: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/9.jpg)
Data integration and communications to
join epidemiology and experimental
medicine Creating the context for a new generation of highly stratified,
highly informative, smaller, cheaper clinical trials
![Page 10: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/10.jpg)
The wider context
![Page 11: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/11.jpg)
Dementia Platforms UK Imaging Network:
delivering the vision
Linking cellular and molecular changes to patient selection and response
Building a national network
![Page 12: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/12.jpg)
Integrated MRI-PET: combined structural and
molecular imaging
http://www.healthcare.siemens.com/magnetic-resonance-imaging/mr-pet-scanner/biograph-mmr
http://www.auntminnieeurope.com/index.aspx?sec=ser&sub=def&pag=dis&ItemID=607775
![Page 13: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/13.jpg)
Lowering barriers to increase imaging
research impact
• Coordination activities and collaborative working groups
• Economies of scale
• Sharing expertise
• Sustainability
• Realising a step change in molecular imaging capabilities
• Making radiotracers more widely available
• Introducing and developing novel MRI-PET platforms
• Harmonising approaches to create a distributed laboratory
• Moving from unlinked to linked imaging data collection
• Building on rigorously maintained cohort studies
• Integrating soluble biomarkers, ‘omics, clinical phenotype and patient reported measures
![Page 14: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/14.jpg)
CRI funded Informatics network
• Cohorts (Swansea)
• Imaging (Oxford)
• Devices (Manchester)
• Genomics (Cardiff)
• Linkage –CRIS (Oxford)
• Brain banking (Bristol)
![Page 15: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/15.jpg)
CRI funded iPS Cells network
• Collaboration across 6 centres
– Cardiff, Oxford, Cambridge, Manchester, Edinburgh, UCL
• Provide neuronal models of clinical phenotypes
• Preserve cell lines from cohorts
• Develop cellular basis of disease stratification
• Interrogate pathogenic pathways
![Page 16: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/16.jpg)
Integrated EM strategy
COHORTS
![Page 17: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/17.jpg)
Innate and
Adaptive Immunity
Integrated EM strategy
COHORTS
Synaptic Health
Vascular Risk
![Page 18: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/18.jpg)
Synaptic Health Vascular risk
Innate and
Adaptive Immunity
Integrated EM strategy
COHORTS
![Page 19: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/19.jpg)
Molecular Imaging
IPS Cells
Informatics
Synaptic Health Vascular risk
Innate and
Adaptive Immunity
Integrated EM strategy
COHORTS
![Page 20: Dr. John Gallacher Digital Health Assembly 2015](https://reader034.vdocuments.site/reader034/viewer/2022042716/55a7385c1a28abc4528b485c/html5/thumbnails/20.jpg)